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Pesquisa : D02.033.415.400 [Categoria DeCS]
Referências encontradas : 947 [refinar]
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[PMID]:28603849
[Au] Autor:Riekhof WR; Nickerson KW
[Ad] Endereço:School of Biological Sciences, University of Nebraska - Lincoln, Lincoln, NE, USA.
[Ti] Título:Quorum sensing in Candida albicans: farnesol versus farnesoic acid.
[So] Source:FEBS Lett;591(12):1637-1640, 2017 Jun.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Read the Original article at doi: 10.1002/1873-3468.12636.
[Mh] Termos MeSH primário: Candida albicans/fisiologia
Farneseno Álcool/metabolismo
Ácidos Graxos Insaturados/metabolismo
Modelos Biológicos
Micélio/fisiologia
Percepção de Quorum
[Mh] Termos MeSH secundário: Regulação Alostérica
Candida albicans/enzimologia
Candida albicans/crescimento & desenvolvimento
Quinases Ciclina-Dependentes/química
Quinases Ciclina-Dependentes/genética
Quinases Ciclina-Dependentes/metabolismo
Proteínas de Ligação a DNA/química
Proteínas de Ligação a DNA/genética
Proteínas de Ligação a DNA/metabolismo
Ácidos Graxos Insaturados/secreção
Proteínas Fúngicas/química
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Regulação Fúngica da Expressão Gênica
Hifas/enzimologia
Hifas/crescimento & desenvolvimento
Hifas/fisiologia
Micélio/enzimologia
Micélio/crescimento & desenvolvimento
Fosforilação
Processamento de Proteína Pós-Traducional
Transporte Proteico
Especificidade da Espécie
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (Fatty Acids, Unsaturated); 0 (Fungal Proteins); 4602-84-0 (Farnesol); 98SID9VM1V (farnesoic acid); EC 2.7.11.22 (Cyclin-Dependent Kinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12694


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[PMID]:28343686
[Au] Autor:Cagliero C; Bicchi C; Cordero C; Liberto E; Rubiolo P; Sgorbini B
[Ad] Endereço:Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, I-10125, Torino, Italy.
[Ti] Título:Analysis of essential oils and fragrances with a new generation of highly inert gas chromatographic columns coated with ionic liquids.
[So] Source:J Chromatogr A;1495:64-75, 2017 Apr 28.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the fields of essential oils and fragrances, samples often consist of mixtures of compounds with similar structural and physical characteristics (e.g. mono- and sesquiterpenoids), whose correct identification closely depends on the synergic combination of chromatographic and mass spectral data. This sample complexity means that new GC stationary phases with different selectivities are continually being investigated. Ionic liquids (ILs) are of great interest as GC stationary phases in this field because of their selectivity (significantly different than that of currently phases) and their high temperature stability. A first generation of IL GC columns was found to be competitive when applied to these field, in terms of selectivity and efficiency, compared to conventional columns (polydimethylsiloxane, (e.g. OV-1), methyl-polysiloxane 5%-phenyl (e.g. SE-52), 7%-cyanopropyl, 7%-phenyl polysiloxane (e.g. OV-1701), and polyethylen glycol (e.g. PEG-20M). However, these columns showed significant activity towards polar or active analytes, which primarily affected their quantitative performance. A new generation of highly-inactive columns coated with three of the most widely-used ionic liquid GC stationary phases has recently been introduced; these phases are SLB-IL60i (1,12-di(tripropylphosphonium) dodecane bis(trifluoromethylsulfonyl) imide [NTf ], SLB-IL76i (tri-(tripropylphosphonium-hexanamido)-triethylamine [NTf ]), and SLB-IL111i (1,5-di (2,3-dimethyllimidazolium) pentane [NTf ]). This study carefully tested the new inert IL columns, in view of their routine application in the fragrance and essential oil fields. They were found to have unusually high selectivity, comparable to that of first-generation IL columns, while their inertness and efficiency were competitive with those of currently-used conventional columns. The IL column performance of first and second generations was compared, through the quali-quantitative analysis of components in a group of different complexity samples; these included the Grob test, a standard mixture of "suspected" skin allergens, and the essential oils of chamomile and sandalwood.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas
Líquidos Iônicos/química
Óleos Voláteis/análise
[Mh] Termos MeSH secundário: Alérgenos/análise
Farneseno Álcool/análise
Óleos Voláteis/química
Extratos Vegetais/química
Santalum/química
Santalum/metabolismo
Sesquiterpenos/análise
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Ionic Liquids); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 1DGG9VW8SA (santalol); 4602-84-0 (Farnesol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:28338641
[Au] Autor:Spicáková A; Szotáková B; Dimunová D; Myslivecková Z; Kubícek V; Ambroz M; Lnenicková K; Krasulová K; Anzenbacher P; Skálová L
[Ad] Endereço:Department of Pharmacology and Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacky University, Hnevotínská 3, 77515 Olomouc, Czech Republic. alena.spicakova@upol.cz.
[Ti] Título:Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions.
[So] Source:Molecules;22(4), 2017 Mar 24.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Sesquiterpenes, 15-carbon compounds formed from three isoprenoid units, are the main components of plant essential oils. Sesquiterpenes occur in human food, but they are principally taken as components of many folk medicines and dietary supplements. The aim of our study was to test and compare the potential inhibitory effect of acyclic sesquiterpenes, -nerolidol, -nerolidol and farnesol, on the activities of the main xenobiotic-metabolizing enzymes in rat and human liver in vitro. Rat and human subcellular fractions, relatively specific substrates, corresponding coenzymes and HPLC, spectrophotometric or spectrofluorometric analysis of product formation were used. The results showed significant inhibition of cytochromes P450 (namely CYP1A, CYP2B and CYP3A subfamilies) activities by all tested sesquiterpenes in rat as well as in human hepatic microsomes. On the other hand, all tested sesquiterpenes did not significantly affect the activities of carbonyl-reducing enzymes and conjugation enzymes. The results indicate that acyclic sesquiterpenes might affect CYP1A, CYP2B and CYP3A mediated metabolism of concurrently administered drugs and other xenobiotics. The possible drug-sesquiterpene interactions should be verified in in vivo experiments.
[Mh] Termos MeSH primário: Inibidores das Enzimas do Citocromo P-450/farmacologia
Sistema Enzimático do Citocromo P-450/metabolismo
Farneseno Álcool/farmacologia
Fígado/enzimologia
Sesquiterpenos/farmacologia
Xenobióticos/metabolismo
[Mh] Termos MeSH secundário: Animais
Inibidores das Enzimas do Citocromo P-450/química
Farneseno Álcool/química
Seres Humanos
Concentração Inibidora 50
Cinética
Ratos
Sesquiterpenos/química
Frações Subcelulares/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Sesquiterpenes); 0 (Xenobiotics); 4602-84-0 (Farnesol); 9035-51-2 (Cytochrome P-450 Enzyme System); QR6IP857S6 (nerolidol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28317391
[Au] Autor:Xia J; Qian F; Xu W; Zhang Z; Wei X
[Ad] Endereço:a Jiangsu Key Laboratory of Oral Diseases , School of Stomatology, Nanjing Medical University , Nanjing , PR China.
[Ti] Título:In vitro inhibitory effects of farnesol and interactions between farnesol and antifungals against biofilms of Candida albicans resistant strains.
[So] Source:Biofouling;33(4):283-293, 2017 Apr.
[Is] ISSN:1029-2454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antifungal resistance is a serious problem in clinical infections. Farnesol, which is a potential antifungal agent against biofilms formed by Candida albicans resistant strains (a fluconazole-resistant isolate derived from SC5314 and two clinical Candida resistant isolates), was investigated in this study. The inhibitory effects of farnesol on biofilms were examined by XTT assay. The morphological changes and biofilm thicknesses were analyzed by scanning electron microscopy and confocal laser scanning microscopy, respectively. Additionally, the checkerboard microdilution method was used to investigate the interactions between farnesol and antifungals (fluconazole, amphotericin B, caspofungin, itraconazole, terbinafine and 5-flurocytosine) against biofilms. The results showed decreased SMICs of farnesol and thinner biofilms in the farnesol-treated groups, indicating that farnesol inhibited the development of biofilms formed by the resistant strain. Furthermore, there were synergistic effects between farnesol and fluconazole/5-flurocytosine, while there were antagonistic effects between farnesol and terbinafine/itraconazole, respectively, on the biofilms formed by the resistant strains.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Biofilmes/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Farmacorresistência Fúngica/efeitos dos fármacos
Farneseno Álcool/farmacologia
[Mh] Termos MeSH secundário: Anfotericina B/farmacologia
Biofilmes/crescimento & desenvolvimento
Candida albicans/fisiologia
Interações Medicamentosas
Equinocandinas/farmacologia
Fluconazol/farmacologia
Seres Humanos
Lipopeptídeos/farmacologia
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Varredura
Naftalenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Echinocandins); 0 (Lipopeptides); 0 (Naphthalenes); 4602-84-0 (Farnesol); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); F0XDI6ZL63 (caspofungin); G7RIW8S0XP (terbinafine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1080/08927014.2017.1295304


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[PMID]:28285658
[Au] Autor:Passera A; Venturini G; Battelli G; Casati P; Penaca F; Quaglino F; Bianco PA
[Ad] Endereço:Department of Agricultural and Environmental Sciences - Production, Landscape, Agroenergy, Università degli Studi di Milano, 20133, Milan, Italy.
[Ti] Título:Competition assays revealed Paenibacillus pasadenensis strain R16 as a novel antifungal agent.
[So] Source:Microbiol Res;198:16-26, 2017 May.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The development of new sustainable containment strategies of plant diseases is very important to guarantee food security while reducing the environmental impact of agriculture. Research of new biocontrol agents is a long and difficult process that involves several steps that start from the identification of possible candidates which, for example, show antibiotic activities, and ends with in field, large scale trials. In this study, the plant growth promoting potential and antifungal effect exerted by a novel, putative candidate biocontrol agent, strain R16, identified as Paenibacillus pasadenensis by sequence analysis of 16S rRNA and rpoB genes, against three important plant pathogenic fungi (Botrytis cinerea, Fusarium verticillioides, and Phomopsis viticola), were assessed. Biochemical assays to determine plant growth promoting potential gave negative results for siderophore production and phosphate solubilization, and positive results for ACC-deamination and IAA production. Further biochemical assays for endophytic lifestyle and antifungal activity gave positive results for catalase and chitinase activity, respectively. In vitro antagonism assays showed that strain R16 is effective against B. cinerea, reducing mycelial growth both in dual-culture and through volatile substances, characterized to be mostly composed by farnesol, and inhibiting conidia germination. Good antagonistic potential was also observed in vitro towards P. viticola, but not towards F. verticillioides. Moreover, in vivo assays confirmed the strain R16 activity reduced the infection rate on B. cinerea-inoculated berries. The obtained results firstly proved that P. pasadenesis strain R16 is a putative plant growth promoter and effective against phytopathogenic fungi. Further studies will be needed to investigate the possible application of this strain as a biocontrol agent.
[Mh] Termos MeSH primário: Antibiose
Ascomicetos/crescimento & desenvolvimento
Paenibacillus/fisiologia
[Mh] Termos MeSH secundário: Antifúngicos/metabolismo
Análise por Conglomerados
DNA Bacteriano/química
DNA Bacteriano/genética
DNA Ribossômico/química
DNA Ribossômico/genética
RNA Polimerases Dirigidas por DNA/genética
Farneseno Álcool/metabolismo
Paenibacillus/crescimento & desenvolvimento
Filogenia
Doenças das Plantas/microbiologia
Doenças das Plantas/prevenção & controle
Reguladores de Crescimento de Planta/metabolismo
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (Plant Growth Regulators); 0 (RNA, Ribosomal, 16S); 4602-84-0 (Farnesol); EC 2.7.7.6 (DNA-Directed RNA Polymerases); EC 2.7.7.6 (RNA polymerase beta subunit)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:28182780
[Au] Autor:Wu L; Pang Y; Qin G; Xi G; Wu S; Wang X; Chen T
[Ad] Endereço:MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, Guangdong, PR China.
[Ti] Título:Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives.
[So] Source:PLoS One;12(2):e0171840, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dihydroartemisinin (DHA) and artesunate (ARS), two artemisinin derivatives, have efficacious anticancer activities against human hepatocarcinoma (HCC) cells. This study aims to study the anticancer action of the combination treatment of DHA/ARS and farnesylthiosalicylic acid (FTS), a Ras inhibitor, in HCC cells (Huh-7 and HepG2 cell lines). FTS pretreatment significantly enhanced DHA/ARS-induced phosphatidylserine (PS) externalization, Bak/Bax activation, mitochondrial membrane depolarization, cytochrome c release, and caspase-8 and -9 activations, characteristics of the extrinsic and intrinsic apoptosis. Pretreatment with Z-IETD-FMK (caspase-8 inhibitor) potently prevented the cytotoxicity of the combination treatment of DHA/ARS and FTS, and pretreatment with Z-VAD-FMK (pan-caspase inhibitor) significantly inhibited the loss of ΔΨm induced by DHA/ARS treatment or the combination treatment of DHA/ARS and FTS in HCC cells. Furthermore, silencing Bak/Bax modestly but significantly inhibited the cytotoxicity of the combination treatment of DHA/ARS and FTS. Interestingly, pretreatment with an antioxidant N-Acetyle-Cysteine (NAC) significantly prevented the cytotoxicity of the combination treatment of DHA and FTS instead of the combination treatment of ARS and FTS, suggesting that reactive oxygen species (ROS) played a key role in the anticancer action of the combination treatment of DHA and FTS. Similar to FTS, DHA/ARS also significantly prevented Ras activation. Collectively, our data demonstrate that FTS potently sensitizes Huh-7 and HepG2 cells to artemisinin derivatives via accelerating the extrinsic and intrinsic apoptotic pathways.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Artemisininas/farmacologia
Carcinoma Hepatocelular/metabolismo
Farneseno Álcool/análogos & derivados
Neoplasias Hepáticas/metabolismo
Salicilatos/farmacologia
[Mh] Termos MeSH secundário: Acetilcisteína/farmacologia
Antineoplásicos/farmacologia
Artemisininas/toxicidade
Sinergismo Farmacológico
Farneseno Álcool/farmacologia
Células Hep G2
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Artemisinins); 0 (Salicylates); 0 (farnesylthiosalicylic acid); 4602-84-0 (Farnesol); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171840


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[PMID]:28151959
[Au] Autor:Schmukler E; Wolfson E; Elazar Z; Kloog Y; Pinkas-Kramarski R
[Ad] Endereço:Department of Neurobiology. Tel-Aviv University, Ramat-Aviv, Israel.
[Ti] Título:Continuous treatment with FTS confers resistance to apoptosis and affects autophagy.
[So] Source:PLoS One;12(2):e0171351, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High percentage of human cancers involves alteration or mutation in Ras proteins, including the most aggressive malignancies, such as lung, colon and pancreatic cancers. FTS (Salirasib) is a farnesylcysteine mimetic, which acts as a functional Ras inhibitor, and was shown to exert anti-tumorigenic effects in vitro and in vivo. Previously, we have demonstrated that short-term treatment with FTS also induces protective autophagy in several cancer cell lines. Drug resistance is frequently observed in cancer cells exposed to prolonged treatment, and is considered a major cause for therapy inefficiency. Therefore, in the present study, we examined the effect of a prolonged treatment with FTS on drug resistance of HCT-116 human colon cancer cells, and the involvement of autophagy in this process. We found that cells grown in the presence of FTS for 6 months have become resistant to FTS-induced cell growth inhibition and cell death. Furthermore, we discovered that the resistant cells exhibit altered autophagy, reduced apoptosis and changes in Ras-related signaling pathways following treatment with FTS. Moreover we found that while FTS induces an apoptosis-related cleavage of p62, the FTS-resistant cells were more resistant to apoptosis and p62 cleavage.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Farneseno Álcool/análogos & derivados
Salicilatos/farmacologia
[Mh] Termos MeSH secundário: Morte Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Resistência a Medicamentos Antineoplásicos
Farneseno Álcool/farmacologia
Genes ras/efeitos dos fármacos
Células HCT116/efeitos dos fármacos
Seres Humanos
Reação em Cadeia da Polimerase em Tempo Real
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Salicylates); 0 (farnesylthiosalicylic acid); 4602-84-0 (Farnesol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171351


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[PMID]:28043124
[Au] Autor:Xu J; Zhang X; Chen Y; Huang Y; Wang P; Wei Y; Ma X; Li S
[Ad] Endereço:Center for Pharmacogenetics, ‡Department of Pharmaceutical Sciences, School of Pharmacy, and §University of Pittsburgh Cancer Institute, University of Pittsburgh , Pittsburgh, Pennsylvania 15261, United States.
[Ti] Título:Improved Micellar Formulation for Enhanced Delivery for Paclitaxel.
[So] Source:Mol Pharm;14(1):31-41, 2017 Jan 03.
[Is] ISSN:1543-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have previously improved the bioactivity of PEG -FTS system by incorporating disulfide bond (PEG -S-S-FTS ) to facilitate the release of farnesyl thiosalicylic acid (FTS).1 Later, fluorenylmethyloxycarbonyl (Fmoc) moiety has been introduced to PEG -FTS system (PEG -Fmoc-FTS ) in order to enhance drug loading capacity (DLC) and formulation stability.2 In this study, we have brought in both disulfide linkage and Fmoc group to PEG -FTS to form a simple PEG -Fmoc-S-S-FTS micellar system. PEG -Fmoc-S-S-FTS conjugate formed filamentous micelles with a ∼10-fold decrease in critical micellar concentration (CMC). Compared with PEG -Fmoc-FTS , our novel system exhibited further strengthened DLC and colloidal stability. More FTS was freed from PEG -Fmoc-S-S-FTS in treated tumor cells compared to PEG -Fmoc-FTS , which was correlated to an increased cytotoxicity of our new carrier in these cancer cells. After loading Paclitaxel (PTX) into PEG -Fmoc-S-S-FTS micelles, it showed more potent efficiency in inhibition of tumor cell proliferation than Taxol and PTX-loaded PEG -Fmoc-FTS . PTX release kinetics of PTX/PEG -Fmoc-S-S-FTS was much slower than that of Taxol and PTX/PEG -Fmoc-FTS in normal release medium. In contrast, in glutathione (GSH)-containing medium, PTX in PEG -Fmoc-S-S-FTS micelles revealed faster and more complete release. Pharmacokinetics and tissue distribution study showed that our PEG -Fmoc-S-S-FTS system maintained PTX in circulation for a longer time and delivered more PTX to tumor sites with less accumulation in major organs. Finally, PTX-loaded PEG -Fmoc-S-S-FTS micelles resulted in a superior therapeutic effect in vivo compared to Taxol and PTX formulated in PEG -Fmoc-FTS micelles.
[Mh] Termos MeSH primário: Paclitaxel/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/metabolismo
Antineoplásicos Fitogênicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Química Farmacêutica/métodos
Portadores de Fármacos/química
Sistemas de Liberação de Medicamentos/métodos
Farneseno Álcool/análogos & derivados
Farneseno Álcool/química
Feminino
Glutationa/química
Camundongos
Camundongos Endogâmicos BALB C
Micelas
Paclitaxel/metabolismo
Paclitaxel/farmacologia
Polietilenoglicóis/química
Salicilatos/química
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Drug Carriers); 0 (Micelles); 0 (Salicylates); 0 (farnesylthiosalicylic acid); 30IQX730WE (Polyethylene Glycols); 4602-84-0 (Farnesol); GAN16C9B8O (Glutathione); P88XT4IS4D (Paclitaxel)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1021/acs.molpharmaceut.6b00581


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[PMID]:27987234
[Au] Autor:Nickerson KW; Atkin AL
[Ad] Endereço:School of Biological Sciences, University of Nebraska, Lincoln, NE, 68588 0666, USA.
[Ti] Título:Deciphering fungal dimorphism: Farnesol's unanswered questions.
[So] Source:Mol Microbiol;103(4):567-575, 2017 Feb.
[Is] ISSN:1365-2958
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Candida albicans excretes E,E-farnesol as a virulence factor and quorum sensing molecule that prevents the yeast to hyphal conversion. Polke et al. (2016) identified eed1Δ/Δ as the first farnesol hypersensitive mutant of C. albicans. eed1Δ/Δ also excretes 10X more farnesol and while able to form hyphae, it cannot maintain hyphae. This mutant enables new research into unanswered questions, including the existence of potential farnesol receptors and transporters, regulation of farnesol synthesis, and relationships among farnesol, germ tube formation and hyphal maintenance. The eed1 farnesol hypersensitivity can be explained by higher internal concentrations of farnesol or lower thresholds for response. One possibility invokes misexpression of a transporter. Saccharomyces cerevisiae and C. albicans have transporters for farnesylated peptides, like the a-factor pheromone, which could potentially also transport farnesol for virulence and quorum sensing. Significantly, these transporters are repressed in MTLa/MTLα C. albicans. An evolutionary pressure for C. albicans to become diploid could derive from its use of farnesol. Alternatively, maintenance of hyphal growth may increase the farnesol response threshold. Finally, Dpp1p, Dpp2p and Dpp3p are non-specific pyrophosphatases responsible for farnesol synthesis. Changes in expression of these enzymes do not explain differences in farnesol levels implicating involvement of additional factors like a scaffolding molecule.
[Mh] Termos MeSH primário: Candida albicans/crescimento & desenvolvimento
Candida albicans/metabolismo
Farneseno Álcool/metabolismo
[Mh] Termos MeSH secundário: Candida albicans/genética
Proteínas Fúngicas/genética
Regulação Fúngica da Expressão Gênica
Hifas/crescimento & desenvolvimento
Percepção de Quorum/fisiologia
Transdução de Sinais
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 0 (Virulence Factors); 4602-84-0 (Farnesol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE
[do] DOI:10.1111/mmi.13601


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[PMID]:27623739
[Au] Autor:Polke M; Sprenger M; Scherlach K; Albán-Proaño MC; Martin R; Hertweck C; Hube B; Jacobsen ID
[Ad] Endereço:Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), Jena, Germany.
[Ti] Título:A functional link between hyphal maintenance and quorum sensing in Candida albicans.
[So] Source:Mol Microbiol;103(4):595-617, 2017 Feb.
[Is] ISSN:1365-2958
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Morphogenesis in Candida albicans requires hyphal initiation and maintenance, and both processes are regulated by the fungal quorum sensing molecule (QSM) farnesol. We show that deletion of C. albicans EED1, which is crucial for hyphal extension and maintenance, led to a dramatically increased sensitivity to farnesol, and thus identified the first mutant hypersensitive to farnesol. Furthermore, farnesol decreased the transient filamentation of an eed1Δ strain without inducing cell death, indicating that two separate mechanisms mediate quorum sensing and cell lysis by farnesol. To analyze the cause of farnesol hypersensitivity we constructed either hyperactive or deletion mutants of factors involved in farnesol signaling, by introducing the hyperactive RAS1 or pADH1-CYR1 allele, or deleting CZF1 or NRG1 respectively. Neither of the constructs nor the exogenous addition of dB-cAMP was able to rescue the farnesol hypersensitivity, highlighting that farnesol mediates its effects not only via the cAMP pathway. Interestingly, the eed1Δ strain also displayed increased farnesol production. When eed1Δ was grown under continuous medium flow conditions, to remove accumulating QSMs from the supernatant, maintenance of eed1Δ filamentation, although not restored, was significantly prolonged, indicating a link between farnesol sensitivity, production, and the hyphal maintenance-defect in the eed1Δ mutant strain.
[Mh] Termos MeSH primário: Candida albicans/crescimento & desenvolvimento
Candida albicans/metabolismo
Farneseno Álcool/metabolismo
Proteínas Fúngicas/genética
Hifas/crescimento & desenvolvimento
Percepção de Quorum/fisiologia
[Mh] Termos MeSH secundário: Candida albicans/genética
AMP Cíclico/metabolismo
Regulação Fúngica da Expressão Gênica
Hifas/metabolismo
Transdução de Sinais
Fatores de Transcrição/genética
Fatores de Virulência/genética
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 0 (Transcription Factors); 0 (Virulence Factors); 148971-43-1 (CZF1 protein, Candida albicans); 4602-84-0 (Farnesol); E0399OZS9N (Cyclic AMP)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.1111/mmi.13526



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