Base de dados : MEDLINE
Pesquisa : D02.033.415.500 [Categoria DeCS]
Referências encontradas : 289 [refinar]
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[PMID]:28107177
[Au] Autor:Quintans JS; Alves RD; Santos DA; Serafini MR; Alves PB; Costa EV; Zengin G; Quintans-Júnior LJ; Guimarães AG
[Ti] Título:Antinociceptive effect of Aristolochia trilobata stem essential oil and 6-methyl-5-hepten-2yl acetate, its main compound, in rodents.
[So] Source:Z Naturforsch C;72(3-4):93-97, 2017 Mar 01.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aristolochia trilobata L. is an aromatic plant, popularly known as "mil-homens", and its essential oil (EO) is generally used to treat colic, diarrhea and dysentery disorders. We evaluated the antinociceptive effect of A. trilobata stem EO and of its major compound, the (R)-(-)-6-methyl-5-hepten-2-yl acetate (sulcatyl acetate: SA), using acetic acid (0.85%)-induced writhing response and formalin-induced (20 µL of 1%) nociceptive behavior in mice. We also evaluated the EO and SA effect on motor coordination, using the rota-rod apparatus. EO (25, 50 and 100 mg/kg) or SA (25 and 50 mg/kg) reduced nociceptive behavior in the writhing test (p<0.001). EO (100 mg/kg) and SA (25 and 50 mg/kg) decreased the nociception on the first phase of the formalin test (p<0.05). On the second phase, EO (25: p<0.01; 50: p<0.05 and 100 mg/kg: p<0.001) and SA (25 and 50 mg/kg; p<0.001) reduced the nociceptive response induced by formalin. EO and SA were not able to cause changes in the motor coordination of animals. Together, our results suggest that EO has an analgesic profile and SA seems to be one of the active compounds in this effect.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Aristolochia/química
Heptanol/farmacologia
Óleos Voláteis/isolamento & purificação
Caules de Planta/química
[Mh] Termos MeSH secundário: Acetatos/antagonistas & inibidores
Acetatos/farmacologia
Analgésicos/isolamento & purificação
Animais
Heptanol/análogos & derivados
Heptanol/isolamento & purificação
Masculino
Camundongos
Óleos Voláteis/química
Medição da Dor
Extratos Vegetais/química
Desempenho Psicomotor/efeitos dos fármacos
Teste de Desempenho do Rota-Rod
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Analgesics); 0 (Oils, Volatile); 0 (Plant Extracts); 8JQ5607IO5 (Heptanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:26970416
[Au] Autor:Zhang S; Zhou Y; Jin S; Meng X; Yang L; Wang H
[Ad] Endereço:School of Tea and Food Technology, Anhui Agricultural University, 130 Chang Jiang West Road, Hefei, 230036, China.
[Ti] Título:Preparation and structural characterization of corn starch-aroma compound inclusion complexes.
[So] Source:J Sci Food Agric;97(1):182-190, 2017 Jan.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Six corn starch inclusion complexes were synthesized using small nonpolar or weak polar aroma compounds (heptanolide, carvone and menthone) and small polar aroma compounds (linalool, heptanol and menthol). The objectives of this study were to (a) investigate the ability of corn starch to form inclusion complexes with these aroma compounds and (b) characterize the structure of the corn starch inclusion complexes. RESULTS: The resulting inclusion ratios were 75.6, 36.9, 43.8, 91.9, 67.2 and 54.7% for heptanolide, carvone, menthone, linalool, heptanol and menthol respectively. The inclusion complexes had laminated structures with a certain amount of holes or blocky constructions. Compared with gelatinized corn starch, the transition temperatures, peak temperatures and enthalpies of the inclusion complexes were significantly different. The major peak of CO at 1771 cm and significant peak shifts revealed the formation of inclusion complexes. X-ray diffractometry (XRD) analyses revealed that the crystallinity of corn starch-polar aroma compound inclusion complexes increased. Based on cross-polarization magic angle spinning C nuclear magnetic resonance (CP-MAS C NMR) results, novel peaks and chemical shifts were attributed to the presence of small aroma compounds, thereby confirming the formation of corn starch inclusion complexes. CONCLUSION: Small nonpolar and polar aroma compounds can be complexed to corn starch. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Amido/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Cristalização
Estabilidade de Medicamentos
Tecnologia de Alimentos
Heptanol/química
Ligações de Hidrogênio
Espectroscopia de Ressonância Magnética
Mentol/química
Microscopia Eletrônica de Varredura
Monoterpenos/química
Sensação
Espectroscopia de Infravermelho com Transformada de Fourier
Amido/ultraestrutura
Termodinâmica
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoterpenes); 1490-04-6 (Menthol); 75GK9XIA8I (carvone); 8JQ5607IO5 (Heptanol); 9005-25-8 (Starch); 9NH5J4V8FN (menthone); D81QY6I88E (linalool)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.7707


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[PMID]:27633494
[Au] Autor:Tse G; Yeo JM; Tse V; Kwan J; Sun B
[Ad] Endereço:Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, P.R. China.
[Ti] Título:Gap junction inhibition by heptanol increases ventricular arrhythmogenicity by reducing conduction velocity without affecting repolarization properties or myocardial refractoriness in Langendorff-perfused mouse hearts.
[So] Source:Mol Med Rep;14(5):4069-4074, 2016 Nov.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:In the current study, arrhythmogenic effects of the gap junction inhibitor heptanol (0.05 mM) were examined in Langendorff-perfused mouse hearts. Monophasic action potential recordings were obtained from the left ventricular epicardium during right ventricular pacing. Regular activity was observed both prior and subsequent to application of heptanol in all of the 12 hearts studied during 8 Hz pacing. By contrast, induced ventricular tachycardia (VT) was observed after heptanol treatment in 6/12 hearts using a S1S2 protocol (Fisher's exact test; P<0.05). The arrhythmogenic effects of heptanol were associated with increased activation latencies from 13.2±0.6 to 19.4±1.3 msec (analysis of variance; P<0.001) and reduced conduction velocities (CVs) from 0.23±0.01 to 0.16±0.01 msec (analysis of variance; P<0.001) in an absence of alterations in action potential durations (ADPs) at x=90% (38.0±1.0 vs. 38.3±1.8 msec), 70% (16.8±1.0 vs. 19.5±0.9 msec), 50% (9.2±0.8 vs. 10.1±0.6 msec) or 30% (4.8±0.5 vs. 6.3±0.6 msec) repolarization (APDx) or in effective refractory period (ERPs) (39.6±1.9 vs. 40.6±3.0 msec) (all P>0.05). Consequently, excitation wavelengths (λ; CV x ERP) were reduced from 9.1±0.6 to 6.5±0.6 mm (P<0.01), however critical intervals for re­excitation (APD90 ­ ERP) were unaltered (­1.1±2.4 vs. ­2.3±1.8 msec; P>0.05). Together, these observations demonstrate for the first time, to the best of our knowledge, that inhibition of gap junctions alone using a low heptanol concentration (0.05 mM) was able to reduce CV, which alone was sufficient to permit the induction of VT using premature stimulation by reducing λ, which therefore appears central in the determination of arrhythmic tendency.
[Mh] Termos MeSH primário: Arritmias Cardíacas/tratamento farmacológico
Sistema de Condução Cardíaco/efeitos dos fármacos
Coração/efeitos dos fármacos
Taquicardia Ventricular/tratamento farmacológico
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Animais
Arritmias Cardíacas/fisiopatologia
Modelos Animais de Doenças
Junções Comunicantes/efeitos dos fármacos
Junções Comunicantes/patologia
Coração/fisiopatologia
Sistema de Condução Cardíaco/fisiopatologia
Ventrículos do Coração/efeitos dos fármacos
Ventrículos do Coração/fisiopatologia
Heptanol/administração & dosagem
Seres Humanos
Camundongos
Miocárdio/patologia
Taquicardia Ventricular/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8JQ5607IO5 (Heptanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2016.5738


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[PMID]:27448454
[Au] Autor:Vinayavekhin N; Sueajai J; Chaihad N; Panrak R; Chokchaisiri R; Sangvanich P; Suksamrarn A; Piyachaturawat P
[Ad] Endereço:Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand; Omics Sciences and Bioinformatics Center, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: nawaporn.v@chula.ac.th.
[Ti] Título:Serum lipidomics analysis of ovariectomized rats under Curcuma comosa treatment.
[So] Source:J Ethnopharmacol;192:273-282, 2016 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma comosa Roxb. (C. comosa) or Wan Chak Motluk, Zingiberaceae family, has been used in Thai traditional medicine for the treatment of gynecological problems and inflammation. AIM OF THE STUDY: This study aimed to investigate the therapeutic potential of C. comosa by determining the changes in the lipid profiles in the ovariectomized rats, as a model of estrogen-deficiency-induced hyperlipidemia, after treatment with different components of C. comosa using an untargeted lipidomics approach. MATERIALS AND METHODS: Lipids were extracted from the serum of adult female rats subjected to a sham operation (SHAM; control), ovariectomy (OVX), or OVX with 12-week daily doses of estrogen (17ß-estradiol; E ), (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (DPHD; a phytoestrogen from C. comosa), powdered C. comosa rhizomes or its crude ethanol extract. They were then analyzed by liquid chromatography-mass spectrometry, characterized, and subjected to the orthogonal projections to latent structures discriminant analysis statistical model to identify tentative biomarkers. RESULTS: Levels of five classes of lipids (ceramide, ceramide-1-phosphate, sphingomyelin, 1-O-alkenyl-lysophosphatidylethanolamine and lysophosphatidylethanolamine) were elevated in the OVX rats compared to those in the SHAM rats, while the monoacylglycerols and triacylglycerols were decreased. The E treatment only reversed the levels of ceramides, whereas treatments with DPHD, C. comosa extract or powder returned the levels of all upregulated lipids back to those in the SHAM control rats. CONCLUSIONS: The findings suggest the potential beneficial effects of C. comosa on preventing the increased ceramide levels in OVX rats, a possible cause of metabolic disturbance under estrogen deficiency. Overall, the results demonstrated the power of untargeted lipidomics in discovering disease-relevant biomarkers, as well as evaluating the effectiveness of treatment by C. comosa components (DPHD, extract or powder) as utilized in Thai traditional medicine, and also providing scientific support for its folklore use.
[Mh] Termos MeSH primário: Curcuma/química
Terapia de Reposição de Estrogênios
Heptanol/análogos & derivados
Hiperlipidemias/tratamento farmacológico
Hipolipemiantes/farmacologia
Lipídeos/sangue
Metabolômica
Ovariectomia
Fitoestrógenos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Cromatografia Líquida
Análise Discriminante
Modelos Animais de Doenças
Estradiol/farmacologia
Etanol/química
Feminino
Heptanol/isolamento & purificação
Heptanol/farmacologia
Hiperlipidemias/sangue
Hiperlipidemias/etiologia
Metabolômica/métodos
Análise Multivariada
Fitoestrógenos/isolamento & purificação
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Pós
Ratos Sprague-Dawley
Rizoma/química
Solventes/química
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1,7-diphenyl-4,6-heptadien-3-ol); 0 (Biomarkers); 0 (Hypolipidemic Agents); 0 (Lipids); 0 (Phytoestrogens); 0 (Plant Extracts); 0 (Powders); 0 (Solvents); 3K9958V90M (Ethanol); 4TI98Z838E (Estradiol); 8JQ5607IO5 (Heptanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27414735
[Au] Autor:Chang CJ; Cheng CC; Chen YC; Kao YH; Chen SA; Chen YJ
[Ad] Endereço:Division of Cardiology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
[Ti] Título:Gap junction modifiers regulate electrical activities of the sinoatrial node and pulmonary vein: Therapeutic implications in atrial arrhythmogenesis.
[So] Source:Int J Cardiol;221:529-36, 2016 Oct 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gap junction (GJ) dysfunctions predispose cardiac tissues to various arrhythmias. Sinoatrial node (SAN) and pulmonary veins (PVs) are closely related atrial dysrhythmia. This study evaluated whether GJ modifications modulate SAN and PVs electrical activities. METHODS: Conventional microelectrodes were used to record action potentials in isolated rabbit SAN, PVs, and connected PV-SAN tissue preparations before and after heptanol (GJ inhibitor) and PQ1 (GJ enhancer) administration with and without isoproterenol. A whole-cell patch clamp was used to record the electrical activities before and after heptanol in single SAN and PV cardiomyocytes. RESULTS: Heptanol (1, 3, and 10µM) reduced the spontaneous beating rates of isolated SAN preparations but not PVs. Heptanol (10µM) decelerated the SAN leading rhythm in the PV-SAN preparations and induced PV burst firings without (3 of 6, 50%) and with (6 of 6, 100%) isoproterenol (1µM). Heptanol (10µM) also reduced the spontaneous beating rates in single SAN cardiomyocyte, but not PV cardiomyocyte, with a decreased pacemaker current. PQ1 (50 and 500nM) treatment did not change the spontaneous beating rates in isolated SAN and PV preparations. In the connected PV-SAN preparations, PQ1 (500nM) did not induce any PV firing even having additional isoproterenol treatment (1µM). Moreover, PQ1 (500nM) prevented heptanol-induced electrical changes in SAN and PVs preparations. CONCLUSION: GJ dysfunction modulates SAN and PV electrical activity, which may contribute to atrial arrhythmogenesis. GJ enhancer has a therapeutic potential in SAN dysfunction and atrial arrhythmogenesis.
[Mh] Termos MeSH primário: Aminoquinolinas/farmacologia
Fibrilação Atrial
Miócitos Cardíacos
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Potenciais de Ação/fisiologia
Animais
Fibrilação Atrial/fisiopatologia
Fibrilação Atrial/prevenção & controle
Fármacos Cardiovasculares/farmacologia
Junções Comunicantes/efeitos dos fármacos
Junções Comunicantes/fisiologia
Átrios do Coração/fisiopatologia
Heptanol/farmacologia
Isoproterenol/farmacologia
Miócitos Cardíacos/efeitos dos fármacos
Miócitos Cardíacos/fisiologia
Veias Pulmonares/fisiopatologia
Coelhos
Nó Sinoatrial/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminoquinolines); 0 (Cardiovascular Agents); 0 (PQ1 compound); 8JQ5607IO5 (Heptanol); L628TT009W (Isoproterenol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE


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[PMID]:26872148
[Au] Autor:Tse G; Tse V; Yeo JM; Sun B
[Ad] Endereço:School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China.
[Ti] Título:Atrial Anti-Arrhythmic Effects of Heptanol in Langendorff-Perfused Mouse Hearts.
[So] Source:PLoS One;11(2):e0148858, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acute effects of heptanol (0.1 to 2 mM) on atrial electrophysiology were explored in Langendorff-perfused mouse hearts. Left atrial bipolar electrogram or monophasic action potential recordings were obtained during right atrial stimulation. Regular pacing at 8 Hz elicited atrial activity in 11 out of 11 hearts without inducing atrial arrhythmias. Programmed electrical stimulation using a S1S2 protocol provoked atrial tachy-arrhythmias in 9 of 17 hearts. In the initially arrhythmic group, 2 mM heptanol exerted anti-arrhythmic effects (Fisher's exact test, P < 0.05) and increased atrial effective refractory period (ERP) from 26.0 ± 1.9 to 57.1 ± 2.5 ms (ANOVA, P < 0.001) despite increasing activation latency from 18.7 ± 1.1 to 28.9 ± 2.1 ms (P < 0.001) and leaving action potential duration at 90% repolarization (APD90) unaltered (25.6 ± 1.2 vs. 27.2 ± 1.2 ms; P > 0.05), which led to increases in ERP/latency ratio from 1.4 ± 0.1 to 2.1 ± 0.2 and ERP/APD90 ratio from 1.0 ± 0.1 to 2.1 ± 0.2 (P < 0.001). In contrast, in the initially non-arrhythmic group, heptanol did not alter arrhythmogenicity, increased AERP from 47.3 ± 5.3 to 54.5 ± 3.1 ms (P < 0.05) and activation latency from 23.7 ± 2.2 to 31.3 ± 2.5 ms and did not alter APD90 (24.1 ± 1.2 vs. 25.0 ± 2.3 ms; P > 0.05), leaving both AERP/latency ratio (2.1 ± 0.3 vs. 1.9 ± 0.2; P > 0.05) and ERP/APD90 ratio (2.0 ± 0.2 vs. 2.1 ± 0.1; P > 0.05) unaltered. Lower heptanol concentrations (0.1, 0.5 and 1 mM) did not alter arrhythmogenicity or the above parameters. The present findings contrast with known ventricular pro-arrhythmic effects of heptanol associated with decreased ERP/latency ratio, despite increased ERP/APD ratio observed in both the atria and ventricles.
[Mh] Termos MeSH primário: Antiarrítmicos/farmacologia
Heptanol/farmacologia
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Animais
Fibrilação Atrial/tratamento farmacológico
Avaliação Pré-Clínica de Medicamentos
Feminino
Coração/efeitos dos fármacos
Coração/fisiopatologia
Sistema de Condução Cardíaco/efeitos dos fármacos
Preparação de Coração Isolado
Masculino
Camundongos da Linhagem 129
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 8JQ5607IO5 (Heptanol)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0148858


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[PMID]:26632516
[Au] Autor:Huang C; Gjelstad A; Seip KF; Jensen H; Pedersen-Bjergaard S
[Ad] Endereço:School of Pharmacy, University of Oslo, PO Box 1068, Blindern, Oslo 0316, Norway; G&T Septech AS, PO Box 33, Ytre Enebakk 1917, Norway. Electronic address: cxhuanglab@icloud.com.
[Ti] Título:Exhaustive and stable electromembrane extraction of acidic drugs from human plasma.
[So] Source:J Chromatogr A;1425:81-7, 2015 Dec 18.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The first part of the current work systematically described the screening of different types of organic solvents as the supported liquid membrane (SLM) for electromembrane extraction (EME) of acidic drugs, including different alcohols, ketones, and ethers. Seven acidic drugs with a wide logP range (1.01-4.39) were selected as model substances. For the first time, the EME recovery of acidic drugs and system-current across the SLM with each organic solvent as SLM were investigated and correlated to relevant solvent properties such as viscosity and Kamlet and Taft solvatochromic parameters. Solvents with high hydrogen bonding acidity (α) and dipolarity-polarizability (π*) were found to be successful SLMs, and 1-heptanol was the most efficient candidate, which provided EME recovery in the range of 94-110%. Both hydrogen bonding interactions, dipole-dipole interactions, and hydrophobic interactions were involved in stabilizing the deprotonated acidic analytes (with high hydrogen bonding basicity and high dipole moment) during mass transfer across the SLM. The efficiency of the extraction normally decreased with increasing hydrocarbon chain length of the SLM, which was mainly due to increasing viscosity and decreasing α and π* values. The system-current during EME was found to be dependent on the type and the volume of the SLM. In contact with human plasma, an SLM of pure 1-heptanol was unstable, and to improve stability, 1-heptanol was mixed with 2-nitrophenyl octyl ether (NPOE). With this SLM, exhaustive EME was performed from diluted human plasma, and the recoveries of five out of seven analytes were over 91% after 10min EME. This approach was evaluated using HPLC-UV, and the evaluation data were found to be satisfactory.
[Mh] Termos MeSH primário: Membranas Artificiais
Preparações Farmacêuticas/sangue
Solventes/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Técnicas Eletroquímicas
Éteres/química
Heptanol/química
Seres Humanos
Ligações de Hidrogênio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2-nitrophenyl octyl ether); 0 (Ethers); 0 (Membranes, Artificial); 0 (Pharmaceutical Preparations); 0 (Solvents); 8JQ5607IO5 (Heptanol)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE


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[PMID]:26152502
[Au] Autor:Yin J; Zhuang X; Wang Q; Cao Y; Zhang S; Xiao C; Li K
[Ad] Endereço:State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
[Ti] Título:Three amino acid residues of an odorant-binding protein are involved in binding odours in Loxostege sticticalis L.
[So] Source:Insect Mol Biol;24(5):528-38, 2015 Oct.
[Is] ISSN:1365-2583
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Odorant-binding proteins (OBPs) play an important role in insect olfactory processes and are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors within the antennal sensilla. As an important general odorant binding protein in the process of olfactory recognition, LstiGOBP1 of Loxostege sticticalis L. has been shown to have good affinity to various plant volatiles. However, the binding specificity of LstiGOBP1 should be further explored in order to better understand the olfactory recognition mechanism of L. sticticalis. In this study, real-time PCR experiments indicated that LstiGOBP1 was expressed primarily in adult antennae. Homology modelling and molecular docking were then conducted on the interactions between LstiGOBP1 and 1-heptanol to understand the interactions between LstiGOBP1 and their ligands. Hydrogen bonds formed by amino acid residues might be crucial for the ligand-binding specificity on molecular docking, a hypothesis that was tested by site-directed mutagenesis. As predicted binding sites for LstiGOBP1, Thr15, Trp43 and Val14 were replaced by alanine to determine the changes in binding affinity. Finally, fluorescence assays revealed that the mutants Thr15 and Trp43 had significantly decreased binding affinity to most odours; in mutants that had two-site mutations, the binding to the six odours that were tested was completely abolished. This result indicates that Thr15 and Trp43 were involved in binding these compounds, possibly by forming multiple hydrogen bonds with the functional groups of the ligands. These results provide new insights into the detailed chemistry of odours' interactions with proteins.
[Mh] Termos MeSH primário: Proteínas de Artrópodes/metabolismo
Mariposas/genética
Odorantes
Receptores Odorantes/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Antenas de Artrópodes/metabolismo
Proteínas de Artrópodes/química
Feminino
Perfilação da Expressão Gênica
Heptanol/química
Masculino
Simulação de Acoplamento Molecular
Dados de Sequência Molecular
Mariposas/metabolismo
Mutagênese Sítio-Dirigida
Ligação Proteica
Receptores Odorantes/química
Receptores Odorantes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arthropod Proteins); 0 (Receptors, Odorant); 0 (odorant-binding protein); 8JQ5607IO5 (Heptanol)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150709
[St] Status:MEDLINE
[do] DOI:10.1111/imb.12179


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[PMID]:26087889
[Au] Autor:Xu E; Long J; Wu Z; Li H; Wang F; Xu X; Jin Z; Jiao A
[Ad] Endereço:The State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan Univ, Wuxi, 214122, China.
[Ti] Título:Characterization of Volatile Flavor Compounds in Chinese Rice Wine Fermented from Enzymatic Extruded Rice.
[So] Source:J Food Sci;80(7):C1476-89, 2015 Jul.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Enzymatic extrusion, instead of traditional steam cooking, to treat rice is an efficient and alternative pretreatment for Chinese rice wine fermentation. In order to determine the formation of volatiles in enzymatic extrusion-processed rice wine (EE), and to confirm its characteristic flavor compounds, headspace solid-phase micro-extraction followed by GC-MS was used. A total of 66 volatile compounds were identified in EE. During fermentation, most volatiles generated from enzymatic extruded rice had the similar trends with those from steam-cooked rice, but the differences in the concentration of volatiles indicated a changed balance of flavors release caused by enzymatic extrusion. Besides, the concentrations and sorts of volatiles in EEs fermented from different rice particle sizes, were not dramatically different. By principal component analysis, EE could be distinctly separated from other traditional Chinese rice wines according to its characteristic volatiles, namely, 2-heptanol, 1-octen-3-ol, ethyl 4-hydroxybenzoate, methylpentyl 2-propenoate, γ-hexalactone, and 4-vinylguaiacol. PRACTICAL APPLICATION: Enzymatic extrusion liquefaction has been a popular thermal treatment for cereals, and gradually being applied in fermentation and liquor-making industry all over the world. The characterization of volatile flavor compounds in Chinese rice wine processed by enzymatic extrusion liquefaction pretreatment, might be made use not only for a better understanding of this new-type rice wine, but for the further utilization of enzymatic extrusion in other wine or alcohol production as well.
[Mh] Termos MeSH primário: Fermentação
Aromatizantes/análise
Oryza
Vinho/análise
[Mh] Termos MeSH secundário: Culinária
Cromatografia Gasosa-Espectrometria de Massas
Guaiacol/análogos & derivados
Guaiacol/química
Heptanol/química
Hidroxibenzoatos/química
Lactonas/química
Octanóis/química
Parabenos/química
Tamanho da Partícula
Extração em Fase Sólida
Microextração em Fase Sólida
Paladar
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavoring Agents); 0 (Hydroxybenzoates); 0 (Lactones); 0 (Octanols); 0 (Parabens); 0 (Volatile Organic Compounds); 6JKA7MAH9C (Guaiacol); 7786-61-0 (4-vinylguaiacol); 8JQ5607IO5 (Heptanol); JG8Z55Y12H (4-hydroxybenzoic acid); WXB511GE38 (1-octen-3-ol)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150716
[Lr] Data última revisão:
150716
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150620
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.12935


  10 / 289 MEDLINE  
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[PMID]:26010217
[Au] Autor:Gibilisco RG; Blanco MB; Bejan I; Barnes I; Wiesen P; Teruel MA
[Ad] Endereço:†Instituto de Investigaciones en Fisicoquímica de Córdoba (I.N.F.I.Q.C.) and CONICET. Dpto. de Fisicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000 Córdoba, Argentina.
[Ti] Título:Atmospheric Sink of (E)-3-Hexen-1-ol, (Z)-3-Hepten-1-ol, and (Z)-3-Octen-1-ol: Rate Coefficients and Mechanisms of the OH-Radical Initiated Degradation.
[So] Source:Environ Sci Technol;49(13):7717-25, 2015 Jul 07.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A kinetic study of the gas-phase reactions of OH radicals with three unsaturated biogenic alcohols, (E)-3-hexen-1-ol, (Z)-3-hepten-1-ol, and (Z)-3-octen-1-ol, has been performed. The rate coefficients obtained are (in units of 10(-10) cm(3) molecule(-1) s(-1)) k1 (OH + (E)-CH2(OH)CH2CH═CHCH2CH3) = (1.14 ± 0.14), k2 (OH + (Z)-CH2(OH)CH2CH═CHCH2CH2CH3) = (1.28 ± 0.23), and k3 (OH + (Z)-CH2(OH)CH2CH═CHCH2CH2CH2CH3) = (1.49 ± 0.35). In addition, a product study on the reactions of OH with (E)-3-hexen-1-ol and (Z)-3-hepten-1-ol is reported. All the experiments were performed at (298 ± 2) K and 1 atm of NOx-free air in a 1080 L photoreactor with in situ FTIR detection of organics. This work constitutes the first kinetic study of the reactions of OH radicals with (Z)-3-hepten-1-ol and (Z)-3-octen-1-ol as well as the first determination of the fate of the hydroxy alkoxy radicals formed in the title reactions. An analysis of the available rates of addition of OH and Cl to the double bond of different unsaturated alcohols at 298 K has shown that they can be related by the expression log kOH = (0.29 ± 0.04) log kCl - 10.8. The atmospheric lifetimes of the alcohols studies were estimated to be around 1 h for reaction with OH radicals. The products formed in the title reactions are mainly carbonylic compounds that can contribute to the formation of ozone and PANs-type compounds in the troposphere.
[Mh] Termos MeSH primário: Atmosfera/química
Heptanol/análogos & derivados
Hexanóis/química
Radical Hidroxila/química
Octanóis/química
[Mh] Termos MeSH secundário: Álcoois/química
Heptanol/química
Cinética
Relação Estrutura-Atividade
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 ((Z)-3-hepten-1-ol); 0 (Alcohols); 0 (Hexanols); 0 (Octanols); 2PL1637OP6 (3-hexen-1-ol); 3352-57-6 (Hydroxyl Radical); 8JQ5607IO5 (Heptanol); WXB511GE38 (1-octen-3-ol)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150527
[St] Status:MEDLINE
[do] DOI:10.1021/es506125c



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