Base de dados : MEDLINE
Pesquisa : D02.033.415.510 [Categoria DeCS]
Referências encontradas : 663 [refinar]
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[PMID]:28141494
[Au] Autor:Hviid AM; Ruhdal-Jensen P; Kilstrup M
[Ad] Endereço:1​Metabolic Signaling and Regulation Group, Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark.
[Ti] Título:Butanol is cytotoxic to Lactococcus lactis while ethanol and hexanol are cytostatic.
[So] Source:Microbiology;163(4):453-461, 2017 Apr.
[Is] ISSN:1465-2080
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lactic acid bacteria currently used extensively by the dairy industry have a superior tolerance towards short-chain alcohols, which makes them interesting targets for use in future bio-refineries. The mechanism underlying the alcohol tolerance of lactic acid bacteria has so far received little attention. In the present study, the physiological alcohol stress response of Lactococcus lactis subsp. cremoris MG1363 towards the primary, even-chain alcohols ethanol, butanol and hexanol, was characterized. The alcohol tolerance of L. lactis was found to be comparable to those reported for highly alcohol-resistant lactic acid bacteria. Combined results from alcohol survival rate, live/dead staining, and a novel usage of the ß-galactosidase assay, revealed that while high concentrations of ethanol and hexanol were cytostatic to L. lactis, high concentrations of butanol were cytotoxic, causing irreparable damages to the cell membrane.
[Mh] Termos MeSH primário: Butanóis/farmacologia
Membrana Celular/efeitos dos fármacos
Etanol/farmacologia
Hexanóis/farmacologia
Lactococcus lactis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Biocombustíveis/microbiologia
Lactococcus lactis/genética
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Butanols); 0 (Hexanols); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1099/mic.0.000441


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[PMID]:28062945
[Au] Autor:Loos HM; Doucet S; Védrines F; Sharapa C; Soussignan R; Durand K; Sagot P; Buettner A; Schaal B
[Ad] Endereço:Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS-Université de Bourgogne, 9E bd Jeanne d'Arc, 21000, Dijon, France. helene.loos@ivv.fraunhofer.de.
[Ti] Título:Responses of Human Neonates to Highly Diluted Odorants from Sweat.
[So] Source:J Chem Ecol;43(1):106-117, 2017 Jan.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Conjugated forms of odorants contributing to sweat odor occur not only in human sweat but also in amniotic fluid, colostrum, and milk. However, it is unclear whether the released odorants are detected and hedonically discriminated by human newborns. To investigate this issue, we administered highly diluted solutions of (R)/(S)-3-methyl-3-sulfanylhexan-1-ol (MSH), (R)/(S)-3-sulfanylhexan-1-ol (SH), (E)/(Z)-3-methylhex-2-enoic acid (3M2H), and (R)/(S)-3-hydroxy-3-methylhexanoic acid (HMHA) to 3-d-old infants while their respiratory rate and oro-facial movements were recorded. Adult sensitivity to these odorants was assessed via triangle tests. Whereas no neonatal stimulus-specific response was found for respiratory rate, oro-facial reactivity indicated orthonasal detection of MSH and SH by male neonates, and of HMHA by the whole group of neonates. Dependent on the dilution of odorants, newborns evinced neutral responses or longer negative oro-facial expressions compared with the reference stimuli. Finally, newborns appeared to be more sensitive to the target odorants than did adults.
[Mh] Termos MeSH primário: Expressão Facial
Comportamento do Lactente
Odorantes
Olfato/fisiologia
Suor
[Mh] Termos MeSH secundário: Adulto
Caproatos/farmacologia
Feminino
Hexanóis/farmacologia
Seres Humanos
Recém-Nascido
Masculino
Taxa Respiratória/efeitos dos fármacos
Ácidos Sulfanílicos/farmacologia
Compostos de Sulfidrila/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-hydroxy-3-methyl-hexanoic acid); 0 (3-methyl-3-sulfonylhexan-1-ol); 0 (Caproates); 0 (Hexanols); 0 (Sulfanilic Acids); 0 (Sulfhydryl Compounds); U3TIX8Z92N (3-mercaptohexanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-016-0804-x


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[PMID]:27979078
[Au] Autor:Lima A; Pereira JA; Baraldi I; Malheiro R
[Ad] Endereço:School of Agriculture, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal; Universidade Tecnológica Federal do Paraná, Campus Medianeira, Avenida Brasil, 4232, Bairro Independência, CEP 85884-000 Medianeira, Paraná, Brazil.
[Ti] Título:Cooking impact in color, pigments and volatile composition of grapevine leaves (Vitis vinifera L. var. Malvasia Fina and Touriga Franca).
[So] Source:Food Chem;221:1197-1205, 2017 Apr 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Grapevine leaves (Vitis vinifera L. var. Malvasia Fina and Touriga Franca) under culinary treatment (blanching and boiling at 60, 75 and 90min) were studied for their color, pigments and volatile fraction changes. Blanching and boiling caused a decrease in luminosity and a loss of green coloration in both varieties, while a yellow-brownish color arose. Significant correlations were established between the loss of green color (monochromatic variable a ) and the total chlorophylls content. The main volatiles in fresh leaves [(Z)-3-hexenal, (Z)-3-hexen-1-ol, and (Z)-3-hexenyl acetate] were drastically reduced by blanching and suppressed by boiling. Other compounds like pentanal and 6-methyl-5-hepten-2 one arose from blanching and boiling. A boiling time of 60min is adequate for the culinary process of grapevine leaves, since the product is considered edible and the pigments and volatile changes are not as drastic as observed at 75 and 90min of boiling.
[Mh] Termos MeSH primário: Culinária
Pigmentos Biológicos/análise
Vitis/química
[Mh] Termos MeSH secundário: Acetatos/análise
Aldeídos/análise
Cor
Hexanóis/análise
Folhas de Planta/química
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-hexenal); 0 (Acetates); 0 (Aldehydes); 0 (Hexanols); 0 (Pigments, Biological); 2PL1637OP6 (3-hexen-1-ol); 3681-71-8 (3-hexenylacetate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27780957
[Au] Autor:Takó M; KotogÁn A; Papp T; Kadaikunnan S; Alharbi NS; VÁgvölgyi C
[Ad] Endereço:Department of Microbiology, Faculty of Science and Informatics, University of Szeged, H-6726 Szeged, Közép fasor 52, Hungary.
[Ti] Título:Purification and Properties of Extracellular Lipases with Transesterification Activity and 1,3-Regioselectivity from and .
[So] Source:J Microbiol Biotechnol;27(2):277-288, 2017 Feb 28.
[Is] ISSN:1738-8872
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:NRRL 5282 and NRRL 1526 can produce lipases with high synthetic activities in wheat bran-based solid-state culture. In this study, the purification and biochemical characterization of the lipolytic activities of these lipases are presented. SDS-PAGE indicated a molecular mass of about 55 and 35 kDa for the purified and enzymes, respectively. -Nitrophenyl palmitate ( NPP) hydrolysis was maximal at 40°C and pH 7.0 for the lipase, and at 30°C and pH 5.2 for the enzyme. The enzymes showed almost equal affinity to NPP, but the of the lipase was about 1.13 times higher than that determined for using the same substrate. For both enzymes, a dramatic loss of activity was observed in the presence of 5 mM Hg , Zn , or Mn , 10 mM -bromosuccinimide or sodium dodecyl sulfate, and 5-10% (v/v) of hexanol or butanol. At the same time, they proved to be extraordinarily stable in the presence of -hexane, cyclohexane, -heptane, and isooctane. Moreover, isopentanol up to 10% (v/v) and propionic acid in 1 mM concentrations increased the NPP hydrolyzing activity of lipase. Both enzymes had 1,3-regioselectivity, and efficiently hydrolyzed -nitrophenyl ( NP) esters with C8-C16 acids, exhibiting maximum activity towards NP-caprylate ( ) and pNP-dodecanoate ( ). The purified lipases are promising candidates for various biotechnological applications.
[Mh] Termos MeSH primário: Lipase/isolamento & purificação
Lipase/metabolismo
Rhizomucor/enzimologia
Rhizopus/enzimologia
[Mh] Termos MeSH secundário: Bromosuccinimida/farmacologia
Butanóis/farmacologia
Caprilatos/farmacologia
Eletroforese em Gel de Poliacrilamida
Esterificação
Heptanos/farmacologia
Hexanos/farmacologia
Hexanóis/farmacologia
Concentração de Íons de Hidrogênio
Hidrólise
Cinética
Lauratos/farmacologia
Lipase/química
Manganês/farmacologia
Mercúrio/farmacologia
Nitrobenzenos/farmacologia
Palmitatos/metabolismo
Propionatos/farmacologia
Rhizomucor/genética
Rhizopus/genética
Dodecilsulfato de Sódio/farmacologia
Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-nitrophenyl dodecanoate); 0 (Butanols); 0 (Caprylates); 0 (Heptanes); 0 (Hexanes); 0 (Hexanols); 0 (Laurates); 0 (Nitrobenzenes); 0 (Palmitates); 0 (Propionates); 1492-30-4 (4-nitrophenyl palmitate); 1956-10-1 (4-nitrophenyloctanoate); 2DDG612ED8 (n-hexane); 368GB5141J (Sodium Dodecyl Sulfate); 42Z2K6ZL8P (Manganese); 456148SDMJ (n-heptane); EC 3.1.1.3 (Lipase); FXS1BY2PGL (Mercury); J41CSQ7QDS (Zinc); JHU490RVYR (propionic acid); K8G1F2UCJF (Bromosuccinimide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161027
[St] Status:MEDLINE
[do] DOI:10.4014/jmb.1608.08005


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[PMID]:27664623
[Au] Autor:Khalil MNA; Fekry MI; Farag MA
[Ad] Endereço:Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini st., Cairo P.B. 11562, Egypt.
[Ti] Título:Metabolome based volatiles profiling in 13 date palm fruit varieties from Egypt via SPME GC-MS and chemometrics.
[So] Source:Food Chem;217:171-181, 2017 Feb 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dates (Phoenix dactylifera L.) are distributed worldwide as major food complement providing a source of sugars and dietary fiber as well as macro- and micronutrients. Although phytochemical analyses of date fruit non-volatile metabolites have been reported, much less is known about the aroma given off by the fruit, which is critical for dissecting sensory properties and quality traits. Volatile constituents from 13 date varieties grown in Egypt were profiled using SPME-GCMS coupled to multivariate data analysis to explore date fruit aroma composition and investigate potential future uses by food industry. A total of 89 volatiles were identified where lipid-derived volatiles and phenylpropanoid derivatives were the major components of date fruit aroma. Multivariate data analyses revealed that 2,3-butanediol, hexanal, hexanol and cinnamaldehyde contributed the most to classification of different varieties. This study provides the most complete map of volatiles in Egyptian date fruit, with Siwi and Sheshi varieties exhibiting the most distinct aroma among studied date varieties.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas
Metaboloma
Phoeniceae/química
Extração em Fase Sólida
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Acroleína/análise
Aldeídos/análise
Butileno Glicóis/análise
Fibras na Dieta/análise
Egito
Frutas/química
Hexanóis/análise
Análise Multivariada
Adoçantes Calóricos/análise
Phoeniceae/classificação
Análise de Componente Principal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 0 (Butylene Glycols); 0 (Dietary Fiber); 0 (Hexanols); 0 (Nutritive Sweeteners); 0 (Volatile Organic Compounds); 45427ZB5IJ (2,3-butylene glycol); 7864XYD3JJ (Acrolein); 9DC2K31JJQ (n-hexanal); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


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[PMID]:27444230
[Au] Autor:Xin ZJ; Li XW; Bian L; Sun XL
[Ad] Endereço:Tea Research Institute,Chinese Academy of Agricultural Sciences,Hangzhou 310008,China.
[Ti] Título:Tea green leafhopper, Empoasca vitis, chooses suitable host plants by detecting the emission level of (3Z)-hexenyl acetate.
[So] Source:Bull Entomol Res;107(1):77-84, 2017 Feb.
[Is] ISSN:1475-2670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Green leaf volatiles (GLVs) have been reported to play an important role in the host-locating behavior of several folivores that feed on angiosperms. However, next to nothing is known about how the green leafhopper, Empoasca vitis, chooses suitable host plants and whether it detects differing emission levels of GLV components among genetically different tea varieties. Here we found that the constitutive transcript level of the tea hydroperoxide lyase (HPL) gene CsiHPL1, and the amounts of (Z)-3-hexenyl acetate and of total GLV components are significantly higher in tea varieties that are susceptible to E. vitis (Enbiao (EB) and Banzhuyuan (BZY)) than in varieties that are resistant to E. vitis (Changxingzisun (CX) and Juyan (JY)). Moreover, the results of a Y-tube olfactometer bioassay and an oviposition preference assay suggest that (Z)-3-hexenyl acetate and (Z)-3-hexenol offer host and oviposition cues for E. vitis female adults. Taken together, the two GLV components, (Z)-3-hexenol and especially (Z)-3-hexenyl acetate, provide a plausible mechanism by which tea green leafhoppers distinguish among resistant and susceptible varieties. Future research should be carried out to obtain the threshold of the above indices and then assess their reasonableness. The development of practical detection indices would greatly improve our ability to screen and develop tea varieties that are resistant to E. vitis.
[Mh] Termos MeSH primário: Acetatos/metabolismo
Aldeídos/metabolismo
Camellia sinensis/metabolismo
Hemípteros/fisiologia
Herbivoria
Hexanóis/metabolismo
[Mh] Termos MeSH secundário: Animais
Sinais (Psicologia)
Cadeia Alimentar
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Aldehydes); 0 (Hexanols); 0 (Plant Proteins); 2PL1637OP6 (3-hexen-1-ol); 3681-71-8 (3-hexenylacetate); 505-57-7 (2-hexenal)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE
[do] DOI:10.1017/S000748531600064X


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[PMID]:27935705
[Au] Autor:Zierer B; Schieberle P; Granvogl M
[Ad] Endereço:Lehrstuhl für Lebensmittelchemie, Technische Universität München , Lise-Meitner-Straße 34, D-85354 Freising, Germany.
[Ti] Título:Aroma-Active Compounds in Bartlett Pears and Their Changes during the Manufacturing Process of Bartlett Pear Brandy.
[So] Source:J Agric Food Chem;64(50):9515-9522, 2016 Dec 21.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Application of aroma extract dilution analysis to Bartlett pears and the fermented mash produced thereof revealed 24 and 34 aroma-active compounds in the flavor dilution (FD) factor range between 8 and 8192. Twenty-eight compounds, which have not been described before in Bartlett pears or in fermented pear mash, were identified. While ethyl (E,Z)-2,4-decadienoate (pear-like, metallic odor impression), hexyl acetate (green, fruity), and acetic acid (vinegar-like) showed the highest concentrations in Bartlett pears, ethanol (ethanolic), acetic acid, 3-methyl-1-butanol (malty), 1-hexanol (grassy, marzipan-like), (S)-2- and 3-methylbutanoic acid (sweaty), and 2-phenylethanol (flowery, honey-like) were present at the highest amounts in the fermented mash. The key aroma compounds were quantitated in each pear brandy production step (pears, fermented mash, distillate, and aged distillate) by stable isotope dilution analysis showing a clear influence of each step on the overall aroma of the spirit and, consequently, revealing clearly changing concentrations (e.g., of ethyl (S)-2-methylbutanoate, (E)-ß-damascenone, ethyl (E,Z)-2,4-decadienoate, and ethyl (E,E)-2,4-decadienoate) and different aroma perceptions during the manufacturing process. In addition, the concentrations of the so-called "pear esters" ethyl (E,Z)-2,4-decadienoate and ethyl (E,E)-2,4-decadienoate were determined in 6 different pear varieties (Abate Fetel, Anjou, Bartlett, Forelle, Kaiser Alexander, and Packham's Triumph) clearly demonstrating the aroma potential of the variety Bartlett, which is mostly used for brandy production due to the high amounts of both esters eliciting a typical pear-like odor impression.
[Mh] Termos MeSH primário: Bebidas Alcoólicas/análise
Fermentação
Odorantes/análise
Pyrus/química
Compostos Orgânicos Voláteis/química
[Mh] Termos MeSH secundário: Etanol/análise
Frutas/química
Cromatografia Gasosa-Espectrometria de Massas
Hexanóis/análise
Seres Humanos
Pentanóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hexanols); 0 (Pentanols); 0 (Volatile Organic Compounds); 3K9958V90M (Ethanol); 6CP2QER8GS (1-hexanol); DEM9NIT1J4 (isopentyl alcohol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04612


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[PMID]:27717473
[Au] Autor:Zhang Y; Fu X; Wang F; Yang Z
[Ad] Endereço:Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China; University of Chinese Academy
[Ti] Título:Spatial differences in (Z)-3-hexen-1-ol production preferentially reduces Spodoptera litura larva attack on the young leaves of Nicotiana benthamiana.
[So] Source:Plant Sci;252:367-373, 2016 Nov.
[Is] ISSN:1873-2259
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Plants synthesize specialized metabolites which possess extremely important ecological functions including direct defense, indirect defense, and signaling. The optimal defense theory (ODT) proposes that defensive metabolites are preferentially allocated to the tissues with high fitness value or in locations that are easily injured. In our present study, using the model plant Nicotiana benthamiana, we found that direct defense of N. benthamiana against Spodoptera litura (Fabricius) larvae showed spatial differences in the sites producing defensive chemicals. The upper leaves possessed significantly stronger direct defense ability than the middle and lower leaves. Interestingly, the strong defense ability of the upper leaves was not due to occurrences of well-known defensive metabolites such as nicotine and chlorogenic acid. After damage, the middle and lower leaves emitted higher amounts of (Z)-3-hexen-1-ol than the upper leaves, which could both attract larvae and significantly increase the amount of middle and lower leaf eaten by the larvae. The spatial difference in (Z)-3-hexen-1-ol emission may be due to spatial differences in expression of lipoxygenase (NbLOX2), which is responsible for the formation and emission of (Z)-3-hexen-1-ol. This study provided new insight into ODT, showing that plants effectively protect easily injured tissues through reduction in concentration of herbivore-feeding stimulant in the tissues.
[Mh] Termos MeSH primário: Herbivoria/efeitos dos fármacos
Hexanóis/farmacologia
Spodoptera/efeitos dos fármacos
Tabaco/fisiologia
[Mh] Termos MeSH secundário: Animais
Hexanóis/metabolismo
Larva/efeitos dos fármacos
Larva/fisiologia
Folhas de Planta/genética
Folhas de Planta/metabolismo
Folhas de Planta/fisiologia
RNA de Plantas/metabolismo
Spodoptera/fisiologia
Tabaco/genética
Tabaco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hexanols); 0 (RNA, Plant); 2PL1637OP6 (3-hexen-1-ol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


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[PMID]:27658323
[Au] Autor:Api AM; Belsito D; Bhatia S; Bruze M; Calow P; Dagli ML; Dekant W; Fryer AD; Kromidas L; La Cava S; Lalko JF; Lapczynski A; Liebler DC; Miyachi Y; Politano VT; Ritacco G; Salvito D; Schultz TW; Shen J; Sipes IG; Wall B; Wilcox DK
[Ad] Endereço:Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: AApi@rifm.org.
[Ti] Título:RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0.
[So] Source:Food Chem Toxicol;97S:S157-S167, 2016 Nov.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
[Mh] Termos MeSH primário: Hexanóis/toxicidade
Perfumes/toxicidade
Testes de Toxicidade/métodos
[Mh] Termos MeSH secundário: Animais
Segurança de Produtos ao Consumidor
Dano ao DNA/efeitos dos fármacos
Relação Dose-Resposta a Droga
Avaliação Pré-Clínica de Medicamentos
Determinação de Ponto Final
Hexanóis/química
Nível de Efeito Adverso não Observado
Perfumes/química
Ratos
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hexanols); 0 (Perfume); 28002VFS3H (2-ethyl-1-butanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


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[PMID]:27600295
[Au] Autor:Api AM; Belsito D; Bhatia S; Bruze M; Calow P; Dagli ML; Dekant W; Fryer AD; Kromidas L; La Cava S; Lalko JF; Lapczynski A; Liebler DC; Penning TM; Politano VT; Ritacco G; Salvito D; Schultz TW; Shen J; Sipes IG; Wall B; Wilcox DK
[Ad] Endereço:Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: AApi@rifm.org.
[Ti] Título:RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7.
[So] Source:Food Chem Toxicol;97S:S147-S156, 2016 Nov.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog 2-butyloctan-1-ol (CAS # 3913-02-8) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental and repeat dose toxicity endpoints were completed data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
[Mh] Termos MeSH primário: Hexanóis/toxicidade
Perfumes/toxicidade
Plastificantes/toxicidade
Testes de Toxicidade/métodos
[Mh] Termos MeSH secundário: Animais
Segurança de Produtos ao Consumidor
Dano ao DNA/efeitos dos fármacos
Relação Dose-Resposta a Droga
Avaliação Pré-Clínica de Medicamentos
Determinação de Ponto Final
Hexanóis/química
Nível de Efeito Adverso não Observado
Perfumes/química
Plastificantes/química
Ratos
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hexanols); 0 (Perfume); 0 (Plasticizers); XZV7TAA77P (2-ethylhexanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE



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