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[PMID]:29024884
[Au] Autor:Mosquera-Vivas CS; Martinez MJ; García-Santos G; Guerrero-Dallos JA
[Ad] Endereço:Department of Chemistry, Faculty of Science, Universidad Nacional de Colombia, Bogotá D.C. 11001, Colombia. Electronic address: carmencita.mosquera@gmail.com.
[Ti] Título:Adsorption-desorption and hysteresis phenomenon of tebuconazole in Colombian agricultural soils: Experimental assays and mathematical approaches.
[So] Source:Chemosphere;190:393-404, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The adsorption-desorption, hysteresis phenomenon, and leachability of tebuconazole were studied for Inceptisol and Histosol soils at the surface (0-10 cm) and in the subsurface (40-50 cm) of an agricultural region from Colombia by the batch-equilibrium method and mathematical approaches. The experimental K and K (L kg ) values (7.9-289.2) decreased with depth for the two Inceptisols and increased with depth for the Histosol due to the organic carbon content, aryl and carbonyl carbon types. Single-point and desorption isotherms depended on adsorption reversibility and suggested that tebuconazole showed hysteresis; which can be adequately evaluated with the single-point desorption isotherm and the linear model using the hysteresis index HI. The most suitable mathematical approach to estimate the adsorption isotherms of tebuconazole at the surface and in the subsurface was that considering the combination of the n-octanol-water partition coefficient, pesticide solubility, and the mass-balance concept. Tebuconazole had similar moderate mobility potential as compared with the values of other studies conducted in temperate amended and unamended soils, but the risk of the fungicide to pollute groundwater sources increased when the pesticide reached subsurface soil layers, particularly in the Inceptisols.
[Mh] Termos MeSH primário: Adsorção
Modelos Teóricos
Poluentes do Solo/análise
Solo
Triazóis/química
[Mh] Termos MeSH secundário: 1-Octanol
Agricultura
Colômbia
Fungicidas Industriais/análise
Fungicidas Industriais/química
Hidrocarbonetos
Praguicidas
Poluentes do Solo/química
Poluentes do Solo/isolamento & purificação
Solubilidade
Triazóis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); 0 (Hydrocarbons); 0 (Pesticides); 0 (Soil); 0 (Soil Pollutants); 0 (Triazoles); 0 (histosol); 401ATW8TRW (tebuconazole); NV1779205D (1-Octanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


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[PMID]:28359554
[Au] Autor:Ranjbar Bandforuzi S; Hadjmohammadi MR
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, NirooHavayii Boulevard, 47416-95447 Babolsar, Iran.
[Ti] Título:Solvent bar microextraction using a reverse micelle containing extraction phase for the determination of warfarin from human plasma by high-performance liquid chromatography.
[So] Source:J Chromatogr A;1496:1-8, 2017 May 05.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:For the first time, solvent bar microextraction using a reverse micelle RMM-SBME as extraction phase was developed for extraction of warfarin in human plasma sample. The reverse micelle of a cationic surfactant (hexadecyltrimethylammonium bromide) in 1-octanol was applied as supported and acceptor phase in SBME. In this process, the analyte was extracted from aqueous samples into a reverse micelle impregnated and also filled in the wall pores and lumen the polypropylene hollow fiber membrane by the electrostatic interactions between the analyte and the surfactant head groups. The influences of fundamental parameters affecting extraction efficiency of warfarin including sample solution pH, surfactant concentration and extraction time were studied using central composite design optimization method. The analysis of extracted analyte was performed by high performance liquid chromatography with ultra violet detector. Under the optimum condition, the sample containing 40ngmL of warfarin was extracted with extraction recovery of 97.8% that pertained to enrichment factor of 260. A good linearity over a concentration range 1-600ngmL with correlation coefficient value of 0.9989 was provided by the current method. Limits of detection and inner and inter-day relative standard deviation were 0.3ngmL and less than 4.4%, respectively. This method was compared to conventional SBME, and illustrated higher extraction efficiency. The method needs minimal sample preparation time since the porous hollow fiber membrane prevents from being extracted potential interfering materials, acts as a filter, and any extra cleanup was not required. The method with bar of 3cm and acceptor phase volume of 8.5µL is environmentally green/friendly method. The proposed method was successfully applied for the preconcentration and determination of warfarin in plasma sample.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Micelas
Solventes/química
Varfarina/sangue
[Mh] Termos MeSH secundário: 1-Octanol/química
Seres Humanos
Microextração em Fase Líquida/métodos
Soluções/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Micelles); 0 (Solutions); 0 (Solvents); 5Q7ZVV76EI (Warfarin); NV1779205D (1-Octanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


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[PMID]:28356191
[Au] Autor:Zhang Y; Lv Q; Qi M; Cai Z
[Ad] Endereço:Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials and School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
[Ti] Título:Performance of permethyl pillar[5]arene stationary phase for high-resolution gas chromatography.
[So] Source:J Chromatogr A;1496:115-121, 2017 May 05.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This work presents the investigation of permethyl pillar[5]arene (MP5) as stationary phase for capillary gas chromatographic (GC) separations. The MP5 capillary column fabricated by the sol-gel coating method exhibited weak polarity and high column efficiency over 4200 plates/m for n-dodecane, n-octanol and naphthalene. Particularly, the MP5 stationary phase displays unique retention for dibromoalkanes, which was found to be closely related with the linker length, and shows high resolving capability for a wide range of positional and structural isomers, including alkylbenzenes, chlorobenzenes and chloronitrobenzenes, naphthalene derivatives, phenols and anilines. Moreover, the MP5 column showed good thermal stability and repeatability and reproducibility with the relative standard deviation in the range of 0.02-0.04% for intra-day, 0.32-0.46% for inter-day and 1.5-3.4% for between-column, respectively. This work demonstrates an promising future of pillar[n]arenes as a new type of stationary phase in chromatographic separations.
[Mh] Termos MeSH primário: Cromatografia Gasosa/métodos
Compostos de Amônio Quaternário/química
[Mh] Termos MeSH secundário: 1-Octanol/química
1-Octanol/isolamento & purificação
Alcanos/química
Alcanos/isolamento & purificação
Cromatografia Gasosa/instrumentação
Isomerismo
Naftalenos/química
Naftalenos/isolamento & purificação
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Naphthalenes); 0 (Quaternary Ammonium Compounds); 0 (pillar(5)arene); 11A386X1QH (n-dodecane); NV1779205D (1-Octanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


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[PMID]:28344173
[Au] Autor:Liu KS; Huang TH; Aljuffali IA; Chen EL; Wang JJ; Fang JY
[Ad] Endereço:Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
[Ti] Título:Exploring the structure-permeation relationship of topical tricyclic antidepressants used for skin analgesia.
[So] Source:Int J Pharm;523(1):386-397, 2017 May 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to evaluate the skin permeation of tricyclic antidepressants (TCAs) with propamine moiety to select candidates for the development of topical analgesics to treat cutaneous pain. We sought to establish the structure-permeation relationship (SPR) of topical TCAs. The lipophilicity, melting point, and aqueous solubility were determined to develop the physicochemical characterization. The TCA permeation into pig and nude mouse skins was estimated using Franz diffusion cell. TCAs and lidocaine were comparatively examined for cutaneous analgesia by pinprick assay. Cutaneous tolerance to TCAs was assessed using nude mouse skin. The skin deposition increased following the increase of lipophilicity after excluding the effect of solubility, with clomipramine exhibiting the highest skin retention. A contrary result was observed for TCA penetration into the receptor. Of the permeants tested, clomipramine demonstrated the best skin-targeting ability. Nortriptyline and clomipramine demonstrated selective uptake into the hair follicles, exhibiting a 2.5-fold higher follicular accumulation than desipramine. Replacement of nitrogen with carbon in the seven-member ring increased skin absorption. The tertiary amine TCAs demonstrated higher absorption than the secondary amine TCAs. The position of the double bond also affected skin transport. Topical clomipramine had a longer duration of analgesic action than lidocaine (240min versus 60min). Exploring the SPR revealed that clomipramine could be an analgesic candidate drug for future development.
[Mh] Termos MeSH primário: Analgésicos
Antidepressivos Tricíclicos
Neuralgia/tratamento farmacológico
Absorção Cutânea
[Mh] Termos MeSH secundário: 1-Octanol/química
Administração Cutânea
Analgesia
Analgésicos/administração & dosagem
Analgésicos/química
Analgésicos/farmacocinética
Analgésicos/uso terapêutico
Animais
Antidepressivos Tricíclicos/administração & dosagem
Antidepressivos Tricíclicos/química
Antidepressivos Tricíclicos/farmacocinética
Antidepressivos Tricíclicos/uso terapêutico
Técnicas In Vitro
Camundongos Nus
Simulação de Acoplamento Molecular
Estrutura Molecular
Propilenoglicol/química
Pele/metabolismo
Suínos
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Antidepressive Agents, Tricyclic); 059QF0KO0R (Water); 6DC9Q167V3 (Propylene Glycol); NV1779205D (1-Octanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:28336459
[Au] Autor:Meng-Lund H; Friis N; van de Weert M; Rantanen J; Poso A; Grohganz H; Jorgensen L
[Ad] Endereço:Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
[Ti] Título:Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme.
[So] Source:Int J Pharm;523(1):238-245, 2017 May 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A quantitative structure-property relationship (QSPR) between protein stability and the physicochemical properties of excipients was investigated to enable a more rational choice of stabilizing excipients than prior knowledge. The thermal transition temperature and aggregation time were determined for lysozyme in combination with 13 different amino acids using high throughput fluorescence spectroscopy and kinetic static light scattering measurements. On the theoretical side, around 200 2D and 3D molecular descriptors were calculated based on the amino acids' chemical structure. Multivariate data analysis was applied to correlate the descriptors with the experimental results. It was possible to identify descriptors, i.e. amino acids properties, with a positive influence on either transition temperature or aggregation onset time, or both. A high number of hydrogen bond acceptor moieties was the most prominent stabilizing factor for both responses, whereas hydrophilic surface properties and high molecular mass density mostly had a positive influence on the unfolding temperature. A high partition coefficient (logP(o/w)) was identified as the most prominent destabilizing factor for both responses. The QSPR shows good correlation between calculated molecular descriptors and the measured stabilizing effect of amino acids on lysozyme.
[Mh] Termos MeSH primário: Aminoácidos/química
Excipientes/química
Muramidase/química
[Mh] Termos MeSH secundário: 1-Octanol/química
Estabilidade de Medicamentos
Desdobramento de Proteína
Relação Quantitativa Estrutura-Atividade
Espectrometria de Fluorescência
Temperatura de Transição
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Excipients); 059QF0KO0R (Water); EC 3.2.1.17 (Muramidase); NV1779205D (1-Octanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  6 / 686 MEDLINE  
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[PMID]:28281884
[Au] Autor:Ahn D; Choi JK; Kim H
[Ad] Endereço:a Department of Environmental Sciences and Biotechnology , Hallym University , Korea.
[Ti] Título:Enhanced removal of NAPL constituent from aquifer during surfactant flushing with aqueous hydraulic barriers of high viscosity.
[So] Source:J Environ Sci Health A Tox Hazard Subst Environ Eng;52(7):590-597, 2017 Jun 07.
[Is] ISSN:1532-4117
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study examines the effect of controlled groundwater flow paths induced by hydraulic barriers on the removal of NAPL constituent. An aqueous solution of thickener [0.05% (w/v) sodium carboxymethyl cellulose, SCMC] was continuously injected into a horizontally set two-dimensional physical model (sand-packed), forming aqueous plume(s) of high viscosity. The water flux at the down gradient of the model was measured using a flux tracer (n-octanol) and passive flux meter (PFM, packs of granular activated carbon). A non-reactive tracer (pentafluorobenzoic acid, PFBA) was used to identify the plume of high viscosity (hydraulic barrier) and ambient groundwater. When the barrier of high viscosity was formed, the plume was separated from the background water with little mixing, which was confirmed by the concentration profile of PFBA; whereas, the measured flux of ambient groundwater showed a distinctive distribution, due to the hydraulic barrier. When two barriers were set, the ambient water flux was enhanced in the middle, and the removal rate of PCE from the non-aqueous phase liquid (NAPL), measured by PFM, was found to improve by 26% during three hours of water flushing. When an aqueous solution of surfactant [0.37% (w/v), sodium dodecyl sulfate, SDS] was applied instead of water into the domain with two barriers set around the NAPL-contaminated spot, the removal of PCE from the NAPL increased by 101% for a three-hour time period. Based on the observations made in this study, hydraulic barriers formed by continuous injection of thickener solution change the flow direction of groundwater, and may increase the flux of groundwater (or aqueous solution of remediation agent) through a NAPL-contaminated region, improving the removal of NAPL.
[Mh] Termos MeSH primário: Água Subterrânea/química
Modelos Teóricos
Dióxido de Silício/química
Tensoativos/química
Movimentos da Água
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: 1-Octanol/análise
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Surface-Active Agents); 0 (Water Pollutants, Chemical); 7631-86-9 (Silicon Dioxide); NV1779205D (1-Octanol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/10934529.2017.1293992


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[PMID]:27940284
[Au] Autor:Vollmer M; Klingebiel M; Rohn S; Maul R
[Ad] Endereço:Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany. Electronic address: Maren.Vollmer@chemie.uni-hamburg.de.
[Ti] Título:Alamethicin for using in bioavailability studies? - Re-evaluation of its effect.
[So] Source:Toxicol In Vitro;39:111-118, 2017 Mar.
[Is] ISSN:1879-3177
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A major pathway for the elimination of drugs is the biliary and renal excretion following the formation of more hydrophilic secondary metabolites such as glucuronides. For in vitro investigations of the phase II metabolism, hepatic microsomes are commonly used in the combination with the pore-forming peptide alamethicin, also to give estimates for the in vivo situation. Thus, alamethicin may represent a neglected parameter in the characterization of microsomal in vitro assays. In the present study, the influence of varying alamethicin concentrations on glucuronide formation of selected phenolic compounds was investigated systematically. A correlation between the alamethicin impact and the lipophilicity of the investigated substrates was analyzed as well. Lipophilicity was determined by the logarithm of the octanol-water partition coefficient. For every substrate, a distinct alamethicin concentration could be detected leading to a maximal glucuronidation activity. Further increase of the alamethicin application led to negative effects. The differences between the maximum depletion rates with and without alamethicin addition varied between 2.7% and 18.2% depending on the substrate. A dependence on the lipophilicity could not be confirmed. Calculation of the apparent intrinsic clearance led to a more than 2-fold increase using the most effective alamethicin concentration compared to the alamethicin free control.
[Mh] Termos MeSH primário: Alameticina/farmacologia
Glucuronídeos/metabolismo
Fenóis/farmacologia
[Mh] Termos MeSH secundário: 1-Octanol/química
Animais
Antibacterianos/farmacologia
Disponibilidade Biológica
Interações Medicamentosas
Masculino
Microssomos Hepáticos/metabolismo
Fenóis/química
Ratos Sprague-Dawley
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glucuronides); 0 (Phenols); 059QF0KO0R (Water); 27061-78-5 (Alamethicin); NV1779205D (1-Octanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27919703
[Au] Autor:Russo G; Grumetto L; Barbato F; Vistoli G; Pedretti A
[Ad] Endereço:Department of Pharmacy, Università degli Studi di Napoli Federico II, via D. Montesano 49, I-80131 Naples, Italy. Electronic address: giacomo.russo@unina.it.
[Ti] Título:Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors.
[So] Source:Eur J Pharm Sci;99:173-184, 2017 Mar 01.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study proposes a method for an in silico calculation of phospholipophilicity. Phospholipophilicity is intended as the measure of analyte affinity for phospholipids; it is currently assessed by HPLC measures of analyte retention on phosphatidylcholine-like stationary phases (IAM - Immobilized Artificial Membrane) resulting in log k values. Due to the amphipathic and electrically charged nature of phospholipids, retention on these stationary phases results from complex mechanisms, being affected not only by lipophilicity (as measured by n-octanol/aqueous phase partition coefficients, log P) but also by the occurrence of polar and/or electrostatic intermolecular interaction forces. Differently from log P, to date no method has been proposed for in silico calculation of log k . The study is aimed both at shedding new light into the retention mechanism on IAM stationary phases and at offering a high-throughput method to achieve such values. A wide set of physico-chemical and topological properties were taken into account, yielding a robust final model including four in silico calculated parameters (lipophilicity, hydrophilic/lipophilic balance, molecular size, and molecule flexibility). The here presented model was based on the analysis of 205 experimentally determined values, taken from the literature and measured by a single research group to minimize the interlaboratory variability; such model is able to predict phospholipophilicity values on both the two IAM stationary phases to date marketed, i.e. IAM.PC.MG and IAM.PC.DD2, with a fairly good degree (r =0.85) of accuracy. The present work allowed the development of a free on-line service aimed at calculating log k values of any molecule included in the PubChem database, which is freely available at http://nova.disfarm.unimi.it/logkwiam.htm.
[Mh] Termos MeSH primário: Fosfolipídeos/química
[Mh] Termos MeSH secundário: 1-Octanol/química
Cromatografia Líquida de Alta Pressão/métodos
Simulação por Computador
Concentração de Íons de Hidrogênio
Interações Hidrofóbicas e Hidrofílicas
Membranas Artificiais
Fosfatidilcolinas/química
Eletricidade Estática
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membranes, Artificial); 0 (Phosphatidylcholines); 0 (Phospholipids); 059QF0KO0R (Water); NV1779205D (1-Octanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


  9 / 686 MEDLINE  
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[PMID]:27908763
[Au] Autor:Stéen EJ; Nyberg N; Lehel S; Andersen VL; Di Pilato P; Knudsen GM; Kristensen JL; Herth MM
[Ad] Endereço:Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
[Ti] Título:Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD ): Evaluation and comparison to existing practices.
[So] Source:Bioorg Med Chem Lett;27(2):319-322, 2017 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In drug discovery, lipophilicity is a key parameter for drug optimization. Lipophilicity determinations can be both work and time consuming, especially for non-UV active compounds. Herein, an improved and simple 1H NMR-based method is described to estimate the lipophilicity at physiological pH (logD ) in 1-octanol and D O buffer. The method can be applied to both UV and non-UV active compounds. In addition, neither calibration curves nor internal/external standards are needed. We have demonstrated that logD can be accurately measured using 1H NMR for compounds within the logD interval between 0.7 and 3.3. The method was also compared to a previously described HPLC method.
[Mh] Termos MeSH primário: Preparações Farmacêuticas/química
[Mh] Termos MeSH secundário: 1-Octanol/química
Óxido de Deutério/química
Concentração de Íons de Hidrogênio
Interações Hidrofóbicas e Hidrofílicas
Espectroscopia de Prótons por Ressonância Magnética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); J65BV539M3 (Deuterium Oxide); NV1779205D (1-Octanol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


  10 / 686 MEDLINE  
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[PMID]:27825061
[Au] Autor:Kinoshita K; Parra E; Needham D
[Ad] Endereço:Center for Single Particle Science and Engineering (SPSE), Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark. Electronic address: koji@sdu.dk.
[Ti] Título:New sensitive micro-measurements of dynamic surface tension and diffusion coefficients: Validated and tested for the adsorption of 1-Octanol at a microscopic air-water interface and its dissolution into water.
[So] Source:J Colloid Interface Sci;488:166-179, 2017 Feb 15.
[Is] ISSN:1095-7103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Currently available dynamic surface tension (DST) measurement methods, such as Wilhelmy plate, droplet- or bubble-based methods, still have various experimental limitations such as the large size of the interface, convection in the solution, or a certain "dead time" at initial measurement. These limitations create inconsistencies for the kinetic analysis of surfactant adsorption/desorption, especially significant for ionic surfactants. Here, the "micropipette interfacial area-expansion method" was introduced and validated as a new DST measurement having a high enough sensitivity to detect diffusion controlled molecular adsorption at the air-water interfaces. To validate the new technique, the diffusion coefficient of 1-Octanol in water was investigated with existing models: the Ward Tordai model for the long time adsorption regime (1-100s), and the Langmuir and Frumkin adsorption isotherm models for surface excess concentration. We found that the measured diffusion coefficient of 1-Octanol, 7.2±0.8×10 cm /s, showed excellent agreement with the result from an alternative method, "single microdroplet catching method", to measure the diffusion coefficient from diffusion-controlled microdroplet dissolution, 7.3±0.1×10 cm /s. These new techniques for determining adsorption and diffusion coefficients can apply for a range of surface active molecules, especially the less-characterized ionic surfactants, and biological compounds such as lipids, peptides, and proteins.
[Mh] Termos MeSH primário: 1-Octanol/química
Ar/análise
Modelos Químicos
Água/química
[Mh] Termos MeSH secundário: Adsorção
Difusão
Cinética
Solubilidade
Tensão Superficial
Temperatura Ambiente
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); NV1779205D (1-Octanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE



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