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[PMID]:28954096
[Au] Autor:AlGhamdi KM; Kumar A; Ashour AE; Al-Rikabi AC; AlOmrani AH; Ahamed SS
[Ad] Endereço:Dermatology Department, College of Medicine, King Saud University - Riyadh, Saudi Arabia.
[Ti] Título:Vascular sclerosing effects of bleomycin on cutaneous veins: a pharmacopathologic study on experimental animals.
[So] Source:An Bras Dermatol;92(4):484-491, 2017 Jul-Aug.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Background:: Varicose veins and the complications of venous disease are common disorders in humans. Objective:: To study the effects of bleomycin as a potential new sclerosing agent and its adverse events in treating varicose veins. Methods:: Bleomycin-loaded liposomes 0.1ml was injected in the dorsal ear veins of white New Zealand rabbits. Sodium tetradecyl sulfate was used as a positive control. Normal saline was used as negative control. The blood vessels of the treated ears were photographed before and at one hour and two, eight and 45 days after treatment. Biopsies from the treated areas were obtained for histological examination. Blood samples were collected to determine any possible toxicity. Results:: Bleomycin by itself was ineffective; therefore, liposomes were used as a vector to deliver bleomycin to the vein lumen. Subsequently, bleomycin started showing its sclerosing effects. Toxicity monitoring showed no apparent hematologic, pulmonary, hepatic or renal toxicities. This study revealed that bleomycin induced vasculitis, which led to vascular occlusion, which was observed on day 1 and day 8. No bleomycin-related injury was noted by histopathological examination of lung sections. The calculation of the lung/body weight coefficient indicated that edema was present in the experimental groups compared with the negative and positive controls. Study limitations:: Relatively small number of experimental animals used. Conclusions:: This study showed that bleomycin-loaded liposomes were able to induce vasculitis and vascular occlusion without any toxicity or complications. It might be useful, hence, to treat patients suffering from Varicose veins and other ectatic vascular diseases with this agent.
[Mh] Termos MeSH primário: Antibióticos Antineoplásicos/administração & dosagem
Bleomicina/farmacologia
Soluções Esclerosantes/farmacologia
Escleroterapia/métodos
Tetradecilsulfato de Sódio/administração & dosagem
Varizes/terapia
[Mh] Termos MeSH secundário: Animais
Bleomicina/administração & dosagem
Modelos Animais de Doenças
Avaliação Pré-Clínica de Medicamentos
Injeções Intravenosas
Lipossomos
Coelhos
Soluções Esclerosantes/administração & dosagem
Soluções Esclerosantes/efeitos adversos
Vasculite/induzido quimicamente
Vasculite/tratamento farmacológico
Veias/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 0 (Liposomes); 0 (Sclerosing Solutions); 11056-06-7 (Bleomycin); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:28430735
[Au] Autor:Jenkinson HA; Wilmas KM; Silapunt S
[Ad] Endereço:*University of Texas McGovern Medical School at Houston, Houston, Texas; †Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, Texas.
[Ti] Título:Sodium Tetradecyl Sulfate: A Review of Clinical Uses.
[So] Source:Dermatol Surg;43(11):1313-1320, 2017 Nov.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sodium tetradecyl sulfate (STS) is Food and Drug Administration approved for treatment of varicose veins, but numerous other off-label applications have been reported. OBJECTIVE: To describe the clinical uses of STS, as well as efficacy and adverse effects. METHODS: Review of studies searchable on PubMed from 1938 to 2016 describing clinical uses of STS to determine efficacy and adverse effects associated with various applications. RESULTS: Sodium tetradecyl sulfate has shown efficacy in the treatment of varicose veins, telangiectasias, hemangioma, pyogenic granuloma, cherry angioma, Kaposi sarcoma, lymphangioma circumscriptum, digital mucous cyst, ganglion cyst, glomangioma, angiokeratoma of Fordyce, pseudocyst of the auricle, and verruca. Commonly reported side effects include pain, erythema, swelling, hyperpigmentation, telangiectatic matting, and ulceration. Serious side effects such as anaphylaxis, pulmonary embolism, stroke, and myocardial infarction have also been reported. Most sources were case reports and small prospective studies, as such the strength of data supporting many uses is limited by small sample sizes and lack of controls. CONCLUSION: Although not always the most effective method of treatment in off-label usage, use of STS has been frequently selected for a variety of applications for reasons of simplicity, low cost, lack of availability of technologically advanced equipment, and intricacies related to anatomic location.
[Mh] Termos MeSH primário: Uso Off-Label
Soluções Esclerosantes/uso terapêutico
Tetradecilsulfato de Sódio/uso terapêutico
Tensoativos/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Soluções Esclerosantes/efeitos adversos
Tetradecilsulfato de Sódio/efeitos adversos
Tensoativos/efeitos adversos
Varizes/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Sclerosing Solutions); 0 (Surface-Active Agents); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001143


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[PMID]:28358710
[Au] Autor:Patel KC; Kalantzis G; El-Hindy N; Chang BY
[Ad] Endereço:Department of Ophthalmology, Huddersfield Royal Infirmary, Huddersfield, U.K. karnesh@doctors.org.uk.
[Ti] Título:Sclerotherapy for Orbital Lymphangioma - Case Series and Literature Review.
[So] Source:In Vivo;31(2):263-266, 2017 Mar-Apr.
[Is] ISSN:1791-7549
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Orbital lymphangioma is a lymphatic system lesion that commonly presents in childhood. Management of these lesions is complex. Sclerotherapy is a therapy used to treat and shrink lesions prior to or as an alternative to surgery. We present three cases of orbital lymphangioma that were treated with sclerotherapy. Case 1: A 6-month-old boy was presented in 2010 with right ptosis and proptosis. Magnetic resonance imaging (MRI) identified a lesion involving the right orbit and face. Case 2: A 3-year-old girl was presented in 2011 with intermittent right periorbital swelling and medial canthal bleeding. MRI identified a soft-tissue lesion in the right orbit, extending into the face. Case 3: A 3-year-old girl was presented in 2012 with vomiting, and painful right proptosis. MRI identified an intra-conal lesion in the right orbit with fluid filled levels. All three patients were treated with sclerotherapy (sodium tetradecylsulfate). Sclerotherapy is a promising treatment for orbital lymphangioma. Its use may prevent the need for, or minimise the amount of surgical management. Several sclerosants are now commonly used to treat these lesions.
[Mh] Termos MeSH primário: Linfangioma/terapia
Neoplasias Orbitárias/terapia
Escleroterapia/métodos
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
Lactente
Linfangioma/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Órbita/diagnóstico por imagem
Órbita/patologia
Neoplasias Orbitárias/diagnóstico por imagem
Soluções Esclerosantes/uso terapêutico
Tetradecilsulfato de Sódio/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Sclerosing Solutions); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


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[PMID]:28114206
[Au] Autor:Chang YY; Lu PH; Yang CH
[Ad] Endereço:Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
[Ti] Título:Anaphylactic Shock After Injection of Foamed Sodium Tetradecyl Sulfate.
[So] Source:Dermatol Surg;43(6):887-888, 2017 06.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anafilaxia/etiologia
Perna (Membro)/irrigação sanguínea
Soluções Esclerosantes/efeitos adversos
Tetradecilsulfato de Sódio/efeitos adversos
Varizes/tratamento farmacológico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Soluções Esclerosantes/administração & dosagem
Tetradecilsulfato de Sódio/administração & dosagem
Ultrassonografia de Intervenção
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sclerosing Solutions); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001016


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[PMID]:28078379
[Au] Autor:Zehtabi F; Dumont-Mackay V; Fatimi A; Bertrand-Grenier A; Héon H; Soulez G; Lerouge S
[Ad] Endereço:Department of Mechanical Engineering, École de technologie supérieure, 1100 Notre-Dame Street West, Montreal, QC, H3C 1K3, Canada.
[Ti] Título:Chitosan-Sodium Tetradecyl Sulfate Hydrogel: Characterization and Preclinical Evaluation of a Novel Sclerosing Embolizing Agent for the Treatment of Endoleaks.
[So] Source:Cardiovasc Intervent Radiol;40(4):576-584, 2017 Apr.
[Is] ISSN:1432-086X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the efficacy of an embolization agent with sclerosing properties (made of chitosan and sodium tetradecyl sulfate, CH-STS) with a similar embolization agent but without sclerosing properties (made of chitosan, CH) in treating endoleaks in a canine endovascular aneurysm repair model. METHODS: Two chitosan-based radiopaque hydrogels were prepared, one with STS and one without STS. Their rheological, injectability, and embolizing properties were assessed in vitro; afterwards, their efficacy in occluding endoleaks was compared in a canine bilateral aneurysm model reproducing type I endoleaks (n = 9 each). The primary endpoint was endoleak persistence at 3 or 6 months, assessed on a CT scan and macroscopic examination. Secondary endpoints were the occurrence of stent-graft (SG) thrombosis, the evolution of the aneurysm mean diameter, as well as aneurysm healing and inflammation scores in pathology examinations. RESULTS: In vitro experiments showed that both products gelled rapidly and presented initial storage moduli greater than 800 Pa, which increased with time. Both gels were compatible with microcatheter injection and occlude flow up to physiological pressure in vitro. In a type I endoleak model, the injection of CH-STS sclerosing gel tended to reduce the risk of occurrence of endoleaks, compared to CH non-sclerosing agent (2/9 vs. 6/9, p = 0.069). No case of SG thrombosis was observed. Moderate inflammation was found around both gels, with a comparable intensity score in both CH and CH-STS groups (2.6 ± 0.9 and 2.7 ± 0.9, respectively; p = 0.789). CONCLUSIONS: Flow occlusion combined with chemical endothelial denudation appears promising for the treatment of endoleaks. LEVEL OF EVIDENCE: N/A.
[Mh] Termos MeSH primário: Quitosana/administração & dosagem
Embolização Terapêutica/métodos
Endoleak/terapia
Hidrogéis/administração & dosagem
Soluções Esclerosantes/administração & dosagem
Tetradecilsulfato de Sódio/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Cães
Procedimentos Endovasculares/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrogels); 0 (Sclerosing Solutions); 9012-76-4 (Chitosan); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1007/s00270-016-1557-1


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[PMID]:28009773
[Au] Autor:Esmaili DD
[Ad] Endereço:Retina Vitreous Associates Medical Group, Los Angeles, California.
[Ti] Título:IATROGENIC OCCLUSION OF THE OPHTHALMIC ARTERY AFTER SODIUM TETRADECYL SULFATE INJECTION IN THE FOREHEAD.
[So] Source:Retin Cases Brief Rep;11 Suppl 1:S28-S30, 2017 Winter.
[Is] ISSN:1937-1578
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe a patient with ophthalmic artery occlusion after sodium tetradecyl sulfate foam injection in the forehead. METHODS: In this case report, a description of the clinical examination and imaging findings, including fundus photography, spectral-domain optical coherence tomography, and fluorescein angiography are reported. RESULTS: A 33-year-old white woman presented with severe painless vision loss in the left eye after cosmetic treatment of a forehead vein with sodium tetradecyl sulfate foam. Her visual acuity in the left eye was hand motions, and her fundus revealed diffuse retinal whitening in the macula with the absence of a cherry red spot and disruption of the arteriolar blood supply. Spectral-domain optical coherence tomography revealed intense hyperreflectivity of the inner and outer retina with loss of the foveal contour, and fluorescein angiography revealed delayed filling of the choroidal vasculature and cilioretinal artery with incomplete filling of the retinal arterioles in the late frames consistent with ophthalmic artery occlusion. CONCLUSION: This case represents a devastating ocular complication after the inadvertent injection of sodium tetradecyl sulfate into a forehead artery, resulting in occlusion of the ophthalmic artery and severe vision loss.
[Mh] Termos MeSH primário: Arteriopatias Oclusivas/induzido quimicamente
Técnicas Cosméticas/efeitos adversos
Artéria Oftálmica
Soluções Esclerosantes/efeitos adversos
Tetradecilsulfato de Sódio/efeitos adversos
Baixa Visão/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Doença Iatrogênica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sclerosing Solutions); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1097/ICB.0000000000000393


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[PMID]:27522970
[Au] Autor:Kayssi A; Oreopoulos G; Tan KT; Jaskolka J
[Ad] Endereço:Division of Vascular Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address: ahmed.kayssi@mail.utoronto.ca.
[Ti] Título:Combined Coil Embolization and Foam Sclerotherapy for the Management of Varicose Veins.
[So] Source:Ann Vasc Surg;38:293-297, 2017 Jan.
[Is] ISSN:1615-5947
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We propose a novel technique for endovenous treatment of varicose veins (VVs) using combined coil embolization and foam sclerotherapy of the great saphenous vein (GSV). METHODS: A retrospective case-series analysis on patients undergoing fluoroscopically guided coil embolization of the GSV and foam sclerotherapy of the GSV and below-knee varices at a single Canadian center. RESULTS: Twenty-two patients underwent the procedure on 23 legs. Most patients (78.3%) presented for follow-up 57.2 ± 21.9 days postoperatively. Doppler studies demonstrated complete GSV occlusion in all patients. While 3 patients (13.6%) noted skin discoloration overlying the treated VVs, none complained of pain on follow-up or developed leg numbness, deep vein thrombosis, or pulmonary emboli. CONCLUSIONS: Coil embolization and foam sclerotherapy are a novel and effective treatment for VVs that uses existing and readily available angiographic equipment.
[Mh] Termos MeSH primário: Embolização Terapêutica/instrumentação
Veia Safena
Soluções Esclerosantes/administração & dosagem
Tetradecilsulfato de Sódio/administração & dosagem
Varizes/terapia
[Mh] Termos MeSH secundário: Idoso
Terapia Combinada
Embolização Terapêutica/efeitos adversos
Feminino
Seres Humanos
Masculino
Meia-Idade
Ontário
Flebografia
Estudos Retrospectivos
Veia Safena/diagnóstico por imagem
Soluções Esclerosantes/efeitos adversos
Escleroterapia/efeitos adversos
Índice de Gravidade de Doença
Tetradecilsulfato de Sódio/efeitos adversos
Fatores de Tempo
Resultado do Tratamento
Ultrassonografia Doppler
Varizes/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sclerosing Solutions); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE


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[PMID]:28397424
[Au] Autor:Kulinski S; Gutkowska O; Gosk J
[Ad] Endereço:Department of Traumatology, Clinical Department of Traumatology and Hand Surgery, Wroclaw Medical University, Wroclaw, Poland.
[Ti] Título:Chemical Substances Used in the Treatment of Ganglions Located in the Hand and Wrist.
[So] Source:Polim Med;46(1):95-100, 2016 Jan-Jun.
[Is] ISSN:0370-0747
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to compare different chemical substances used in the treatment of ganglions located in the hand and wrist region. Their basic properties and mechanisms of action have been described. Moreover, the risks associated with the use of particular substances have been highlighted and potential complications connected with their administration have been discussed. On the basis of the available literature, the results of ganglion aspiration treatment followed by an injection of a chemical substance into the cyst cavity have been assessed. In the authors' opinion, due to the existing risk of complications associated with this treatment, as well as the relatively high rate of ganglion recurrence, this procedure should only be performed by qualified medical personnel. The authors recommend observation in cases of asymptomatic ganglions of the hand and wrist, and operative treatment in cases in which pain, restriction of limb mobility and weakening of handgrip strength are observed.
[Mh] Termos MeSH primário: Cistos Glanglionares/tratamento farmacológico
Mãos
Hialuronoglucosaminidase/uso terapêutico
Pregnanos/uso terapêutico
Tetradecilsulfato de Sódio/uso terapêutico
Punho
[Mh] Termos MeSH secundário: Anti-Inflamatórios/efeitos adversos
Anti-Inflamatórios/uso terapêutico
Seres Humanos
Hialuronoglucosaminidase/administração & dosagem
Hialuronoglucosaminidase/efeitos adversos
Pregnanos/efeitos adversos
Recidiva
Tetradecilsulfato de Sódio/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Pregnanes); EC 3.2.1.35 (Hyaluronoglucosaminidase); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.17219/pim/64803


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[PMID]:27688283
[Au] Autor:Sio WS; Lee SH; Liang IC
[Ad] Endereço:Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.
[Ti] Título:Orbital infarction syndrome after multiple percutaneous sclerotherapy sessions for facial low-flow vascular malformation: A case report and literature review.
[So] Source:Indian J Ophthalmol;64(8):595-7, 2016 Aug.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Vision loss following sclerotherapy for facial vascular malformations (VMs) is a rare but detrimental complication. Here, we report a case of an 11-year-old boy with acute onset blepharoptosis, ophthalmoplegia, and blindness in his right eye after the 14 th sclerotherapy session (percutaneous intralesional injection of sodium tetradecyl sulfate) for a right facial low-flow VM without orbital involvement. Computed tomography angiography revealed no contrast enhancement in the right ophthalmic artery, superior ophthalmic vein, or extraocular muscles. He presented with the hallmarks of orbital infarction syndrome: Clear signs of anterior and posterior segment ischemia and disrupted arterial flow to the extraocular muscles. His blepharoptosis and eye movement improved 4 months later; however, he remained blind, and phthisis bulbi developed eventually. Thus, sclerotherapy for facial VM-even without orbital involvement--may result in severe ocular and orbital complications.
[Mh] Termos MeSH primário: Face/irrigação sanguínea
Infarto/etiologia
Órbita/irrigação sanguínea
Escleroterapia/efeitos adversos
Tetradecilsulfato de Sódio/efeitos adversos
Malformações Vasculares/terapia
[Mh] Termos MeSH secundário: Blefaroptose/diagnóstico
Blefaroptose/etiologia
Cegueira/diagnóstico
Cegueira/etiologia
Criança
Angiografia por Tomografia Computadorizada
Seres Humanos
Infarto/diagnóstico
Imagem por Ressonância Magnética
Masculino
Oftalmoplegia/diagnóstico
Oftalmoplegia/etiologia
Malformações Vasculares/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.4103/0301-4738.191508


  10 / 397 MEDLINE  
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[PMID]:26957907
[Au] Autor:Chang IS; Park SW; Kwon SY; Choe WH; Cheon YK; Shim CS; Lee TY; Kim JH
[Ad] Endereço:Department of Radiology, Digestive Disease Center, Konkuk University School of Medicine, Seoul 05030, Korea.
[Ti] Título:Efficacy and Safety of Balloon-Occluded Retrograde Transvenous Obliteration with Sodium Tetradecyl Sulfate Liquid Sclerotherapy.
[So] Source:Korean J Radiol;17(2):224-9, 2016 Mar-Apr.
[Is] ISSN:2005-8330
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the efficacy and safety of balloon-occluded retrograde transvenous obliteration (BRTO) with sodium tetradecyl sulfate (STS) liquid sclerotherapy of gastric varices. MATERIALS AND METHODS: Between February 2012 and August 2014, STS liquid sclerotherapy was performed in 17 consecutive patients (male:female = 8:9; mean age 58.6 years, range 44-86 years) with gastric varices. Retrograde venography was performed after occlusion of the gastrorenal shunt using a balloon catheter and embolization of collateral draining veins using coils or gelfoam pledgets, to evaluate the anatomy of the gastric varices. We prepared 2% liquid STS by mixing 3% STS and contrast media in a ratio of 2:1. A 2% STS solution was injected into the gastric varices until minimal filling of the afferent portal vein branch was observed (mean 19.9 mL, range 6-33 mL). Patients were followed up using computed tomography (CT) or endoscopy. RESULTS: Technical success was achieved in 16 of 17 patients (94.1%). The procedure failed in one patient because the shunt could not be occluded due to the large diameter of gastrorenal shunt. Complete obliteration of gastric varices was observed in 15 of 16 patients (93.8%) with follow-up CT or endoscopy. There was no rebleeding after the procedure. There was no procedure-related mortality. CONCLUSION: BRTO using STS liquid can be a safe and useful treatment option in patients with gastric varices.
[Mh] Termos MeSH primário: Meios de Contraste/química
Varizes Esofágicas e Gástricas/terapia
Tetradecilsulfato de Sódio/química
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Oclusão com Balão
Demografia
Embolização Terapêutica
Endoscopia do Sistema Digestório
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Veia Porta/diagnóstico por imagem
Escleroterapia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.3348/kjr.2016.17.2.224



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