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  1 / 3714 MEDLINE  
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[PMID]:29208467
[Au] Autor:Aduri NG; Ernst HA; Prabhala BK; Bhatt S; Boesen T; Gajhede M; Mirza O
[Ad] Endereço:Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[Ti] Título:Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state.
[So] Source:Biochem Biophys Res Commun;495(2):1738-1743, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human proton coupled folic acid transporter PCFT is the major import route for dietary folates. Mutations in the gene encoding PCFT cause hereditary folic acid malabsorption, which manifests itself by compromised folate absorption from the intestine and also in impaired folate transport into the central nervous system. Since its recent discovery, PCFT has been the subject of numerous biochemical studies aiming at understanding its structure and mechanism. One major focus has been its oligomeric state, with some reports supporting oligomers and others a monomer. Here, we report the overexpression and purification of recombinant PCFT. Following detergent screening, n-Dodecyl ß-D-maltoside (DDM) and lauryl maltose neopentyl glycol (LMNG) were chosen for further work as they exhibited the most optimal solubilization. We found that purified detergent solubilized PCFT was able to bind folic acid, thus indicating a functionally active protein. Size exclusion chromatography showed that PCFT in DDM was polydisperse; the LMNG preparation was clearly monodisperse but with shorter retention time than the major DDM peak. To assess the oligomeric state negative stain electron microscopy was performed which showed a particle with the size of a PCFT dimer.
[Mh] Termos MeSH primário: Transportador de Folato Acoplado a Próton/química
[Mh] Termos MeSH secundário: Animais
Detergentes
Ácido Fólico/metabolismo
Glucosídeos
Glicóis
Seres Humanos
Ligantes
Microscopia Eletrônica
Modelos Moleculares
Multimerização Proteica
Estrutura Quaternária de Proteína
Transportador de Folato Acoplado a Próton/metabolismo
Transportador de Folato Acoplado a Próton/ultraestrutura
Proteínas Recombinantes/química
Proteínas Recombinantes/metabolismo
Proteínas Recombinantes/ultraestrutura
Células Sf9
Solubilidade
Spodoptera
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Detergents); 0 (Glucosides); 0 (Glycols); 0 (Ligands); 0 (Proton-Coupled Folate Transporter); 0 (Recombinant Proteins); 0 (SLC46A1 protein, human); 69227-93-6 (dodecyl maltoside); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  2 / 3714 MEDLINE  
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[PMID]:28454494
[Au] Autor:Qu S; Zhao L; Zhu J; Wang C; Dai C; Guo H; Hao Z
[Ad] Endereço:a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , Qingdao , China and.
[Ti] Título:Preparation and testing of cefquinome-loaded poly lactic-co-glycolic acid microspheres for lung targeting.
[So] Source:Drug Deliv;24(1):745-751, 2017 Nov.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to prepare cefquinome-loaded poly lactic-co-glycolic acid (PLGA) microspheres and to evaluate their in vitro and in vivo characteristics. Microspheres were prepared using a spry drier and were characterized in terms of morphology, size, drug-loading coefficient, encapsulation ratio and in vitro release. The prepared microspheres were spherical with smooth surfaces and uniform size (12.4 ± 1.2 µm). The encapsulation efficiency and drug loading of cefquinome was 91.6 ± 2.6 and 18.3 ± 1.3%, respectively. In vitro release of cefquinome from the microspheres was sustained for 36 h. In vivo studies identified the lung as the target tissue and the region of maximum cefquinome release. A partial lung inflammation was observed but disappeared spontaneously as the microspheres were removed through in vivo decay. The sustained cefquinome release from the microspheres revealed its applicability as a drug delivery system that minimized exposure to healthy tissues while increasing the accumulation of therapeutic drug at the target site. These results indicated that the spray-drying method of loading cefquinome into PLGA microspheres is a straightforward method for lung targeting in animals.
[Mh] Termos MeSH primário: Microesferas
[Mh] Termos MeSH secundário: Animais
Cefalosporinas
Glicóis
Ácido Láctico
Pulmão
Tamanho da Partícula
Ácido Poliglicólico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cephalosporins); 0 (Glycols); 0 (polylactic acid-polyglycolic acid copolymer); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); Z74S078CWP (cefquinome)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1080/10717544.2017.1321058


  3 / 3714 MEDLINE  
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[PMID]:28665959
[Au] Autor:Talsma DT; Katta K; Boersema M; Adepu S; Naggi A; Torri G; Stegeman C; Navis G; van Goor H; Hillebrands JL; Yazdani S; van den Born J
[Ad] Endereço:Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands.
[Ti] Título:Increased migration of antigen presenting cells to newly-formed lymphatic vessels in transplanted kidneys by glycol-split heparin.
[So] Source:PLoS One;12(6):e0180206, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chronic renal transplant dysfunction is characterized by loss of renal function and tissue remodeling, including chronic inflammation and lymph vessel formation. Proteoglycans are known for their chemokine presenting capacity. We hypothesize that interruption of the lymphatic chemokine-proteoglycan interaction interferes with the lymphatic outflow of leukocytes from the renal graft and might decrease the anti-graft allo-immune response. METHODS: In a rat renal chronic transplant dysfunction model (female Dark-Agouti to male Wistar Furth), chemokines were profiled by qRT-PCR in microdissected tubulo-interstitial tissue. Disruption of lymphatic chemokine-proteoglycan interaction was studied by (non-anticoagulant) heparin-derived polysaccharides in vitro and in renal allografts. The renal allograft function was assessed by rise in plasma creatinine and urea. RESULTS: Within newly-formed lymph vessels of transplanted kidneys, numerous CD45+ leukocytes were found, mainly MHCII+, ED-1-, IDO-, HIS14-, CD103- antigen presenting cells, most likely representing a subset of dendritic cells. Treatment of transplanted rats with regular heparin and two different (non-)anticoagulant heparin derivatives revealed worsening of kidney function only in the glycol-split heparin treated group despite a two-fold reduction of tubulo-interstitial leukocytes (p<0.02). Quantitative digital image analysis however revealed increased numbers of intra-lymphatic antigen-presenting cells only in the glycol-split heparin group (p<0.01). The number of intra-lymphatic leukocytes significantly correlates with plasma creatinine and urea, and inversely with creatinine clearance. CONCLUSIONS: Treatment of transplanted rats with glycol-split heparin significantly increases the number of intra-lymphatic antigen presenting cells, by increased renal diffusion of lymphatic chemokines, thereby increasing the activation and recruitment of antigen presenting cells towards the lymph vessel. This effect is unwanted in the transplantation setting, but might be advantageous in e.g., dendritic cell vaccination.
[Mh] Termos MeSH primário: Células Apresentadoras de Antígenos/citologia
Movimento Celular
Glicóis/química
Heparina/farmacologia
Transplante de Rim
Vasos Linfáticos/citologia
[Mh] Termos MeSH secundário: Animais
Ensaio de Imunoadsorção Enzimática
Feminino
Heparina/química
Imuno-Histoquímica
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycols); 9005-49-6 (Heparin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180206


  4 / 3714 MEDLINE  
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[PMID]:28626136
[Au] Autor:Kawamura H; Takeda Y; Tagawa T; Katuura H; Shiomi M
[Ad] Endereço:Department of Applied Chemistry and Biotechnology, National Institute of Technology.
[Ti] Título:Effect of Hydroxyl Groups on Solubilization States of Alkandiols in DTAB Micelles: Application of a Differential Conductivity Technique.
[So] Source:J Oleo Sci;66(7):705-711, 2017 Jul 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The partition coefficients, K , of 1,2-alkanediols and α,ω-alkanediols between dodecyltrimethylammonium bromide (DTAB) micelles and water, and the change of the degree of counterion dissociation, dα/dX , on DTAB micelles associated with solubilization of the alkanediols are determined by a differential conductivity technique. The standard Gibbs energy change of transfer per methylene group, ΔG (CH ), is estimated from a dependence of logarithmic value of the K on the carbon number of alkyl chain in the alkanediols. The dα/dX is independent of the carbon number of alkyl chain in the alkanediols. Comparing the present results with those of DTAB/1-alkanols system, it is suggested that solubilization states of the alkanediols in DTAB micelles are as follows: 1,2-alkanediols are solubilized as its alkyl chain is oriented to micellar interior just like 1-alkanols, while α,ω-alkanediols are solubilized as its alkyl chain is partly located in micellar surface region.
[Mh] Termos MeSH primário: Condutividade Elétrica
Glicóis/química
Micelas
Tensoativos/química
[Mh] Termos MeSH secundário: Carbono/química
Transferência de Energia
Compostos de Amônio Quaternário/química
Solubilidade
Relação Estrutura-Atividade
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycols); 0 (Micelles); 0 (Quaternary Ammonium Compounds); 0 (Surface-Active Agents); 059QF0KO0R (Water); 7440-44-0 (Carbon); GT3793XV5S (dodecyltrimethylammonium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17013


  5 / 3714 MEDLINE  
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[PMID]:28621498
[Au] Autor:Hu Y; Li N; Li G; Wang A; Cong Y; Wang X; Zhang T
[Ad] Endereço:State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, PR China.
[Ti] Título:Sustainable Production of o-Xylene from Biomass-Derived Pinacol and Acrolein.
[So] Source:ChemSusChem;10(14):2880-2885, 2017 Jul 21.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:o-Xylene (OX) is a large-volume commodity chemical that is conventionally produced from fossil fuels. In this study, an efficient and sustainable two-step route is used to produce OX from biomass-derived pinacol and acrolein. In the first step, the phosphotungstic acid (HPW)-catalyzed pinacol dehydration in 1-ethyl-3-methylimidazolium chloride ([emim]Cl) selectively affords 2,3-dimethylbutadiene. The high selectivity of this reaction can be ascribed to the H-bonding interaction between Cl and the hydroxy group of pinacol. The stabilization of the carbocation intermediate by the surrounding anion Cl may be another reason for the high selectivity. Notably, the good reusability of the HPW/[emim]Cl system can reduce the waste output and production cost. In the second step, OX is selectively produced by a Diels-Alder reaction of 2,3-dimethylbutadiene and acrolein, followed by a Pd/C-catalyzed decarbonylation/aromatization cascade in a one-pot fashion. The sustainable two-step process efficiently produces renewable OX in 79 % overall yield. Analogously, biomass-derived crotonaldehyde and pinacol can also serve as the feedstocks for the production of 1,2,4-trimethylbenzene.
[Mh] Termos MeSH primário: Acroleína/química
Biomassa
Glicóis/química
Química Verde
Xilenos/química
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycols); 0 (Xylenes); 0 (pinacol); 7864XYD3JJ (Acrolein); Z2474E14QP (2-xylene)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700823


  6 / 3714 MEDLINE  
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[PMID]:28381810
[Au] Autor:Yanamoto S; Babazada H; Sakai S; Higuchi Y; Yamashita F; Hashida M
[Ad] Endereço:Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University.
[Ti] Título:Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages.
[So] Source:Biol Pharm Bull;40(4):540-545, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Glycosaminoglycans (GAGs) play important roles in various biological processes such as cell adhesion and signal transduction, as well as promote anti-inflammatory activity. We previously revealed that glycol-split heparin (HP)-aliphatic amine conjugates form self-assembled nanoparticles and suppress the production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1ß in lipopolysaccharide (LPS)-stimulated macrophages much more strongly than native HP (J. CONTROL: Release, 194, 2014, Babazada et al.). Considering that HP is not the only GAG to have anti-inflammatory activity, the present study was initiated to examine whether conjugation of GAGs with aliphatic amines is generally effective in their activity augmentation against LPS-stimulated macrophages. We newly synthesized the stearylamine conjugates of chondroitin sulfate (CS), hyaluronic acid (HA), and low-molecular-weight heparin (LH), and investigated the effect of the position and degree of sulfation and molecular weight of GAGs on their anti-inflammatory activity. All of the conjugates formed self-assembled nanoparticles in aqueous solution. The IC value for suppression of TNF-α production from the macrophages was the smallest with the derivative of LH, followed by HP, CS, and HA. The degree of sulfation appeared to be important in determining their anti-inflammatory activity, which would correspond to previous results using the derivatives of site-selectively desulfated HP. Comparison of HP and LH derivatives revealed that fractionated smaller heparin has greater anti-inflammatory activity.
[Mh] Termos MeSH primário: Aminas/farmacologia
Anti-Inflamatórios/farmacologia
Glicosaminoglicanos/farmacologia
Mediadores da Inflamação/antagonistas & inibidores
Lipopolissacarídeos/toxicidade
Macrófagos Peritoneais/metabolismo
[Mh] Termos MeSH secundário: Aminas/química
Animais
Anti-Inflamatórios/química
Relação Dose-Resposta a Droga
Glicóis/química
Glicóis/farmacologia
Glicosaminoglicanos/química
Mediadores da Inflamação/metabolismo
Macrófagos Peritoneais/efeitos dos fármacos
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Anti-Inflammatory Agents); 0 (Glycols); 0 (Glycosaminoglycans); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); FFV58UNY7O (stearylamine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00928


  7 / 3714 MEDLINE  
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[PMID]:28277620
[Au] Autor:Brentzel ZJ; Barnett KJ; Huang K; Maravelias CT; Dumesic JA; Huber GW
[Ad] Endereço:Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
[Ti] Título:Chemicals from Biomass: Combining Ring-Opening Tautomerization and Hydrogenation Reactions to Produce 1,5-Pentanediol from Furfural.
[So] Source:ChemSusChem;10(7):1351-1355, 2017 Apr 10.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A process for the synthesis of 1,5-pentanediol (1,5-PD) with 84 % yield from furfural is developed, utilizing dehydration/hydration, ring-opening tautomerization, and hydrogenation reactions. Although this process has more reaction steps than the traditional direct hydrogenolysis of tetrahydrofurfuryl alcohol (THFA), techno-economic analyses demonstrate that this process is the economically preferred route for the synthesis of biorenewable 1,5-PD. 2-Hydroxytetrahydropyran (2-HY-THP) is the key reaction pathway intermediate that allows for a decrease in the minimum selling price of 1,5-PD. The reactivity of 2-HY-THP is 80 times greater than that of THFA over a bimetallic hydrogenolysis catalyst. This enhanced reactivity is a result of the ring-opening tautomerization to 5-hydoxyvaleraldehyde and subsequent hydrogenation to 1,5-PD.
[Mh] Termos MeSH primário: Biomassa
Furaldeído/química
Glicóis/química
Pentanos/química
[Mh] Termos MeSH secundário: Hidrogenação
Isomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycols); 0 (Pentanes); 07UXZ0SCST (1,5-pentanediol); DJ1HGI319P (Furaldehyde)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700178


  8 / 3714 MEDLINE  
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[PMID]:28077599
[Au] Autor:Lv J; Xiong Y; Li W; Yang W; Zhao L; He R
[Ad] Endereço:Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, People's Republic of China; and.
[Ti] Título:BLT1 Mediates Bleomycin-Induced Lung Fibrosis Independently of Neutrophils and CD4+ T Cells.
[So] Source:J Immunol;198(4):1673-1684, 2017 Feb 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leukotriene B (LTB4) and its functional receptor BLT1 are closely involved in tissue inflammation by primarily mediating leukocyte recruitment and activation. Elevated LTB4 was reported in patients with lung fibrosis; however, the role of the LTB4/BLT1 axis in lung fibrosis remains unknown. In this study, we demonstrated that BLT1 mice exhibited significantly attenuated bleomycin (BLM)-induced lung fibrosis. Interestingly, BLT1 blockade with its specific antagonist U75302 in the acute injury phase (days 0-10 after BLM treatment) significantly attenuated lung fibrosis, which was accompanied by significant decreases in early infiltrating neutrophils and later infiltrating CD4 T cells and the production of TGF-ß, IL-13, and IL-17A. In contrast, BLT1 blockade in the fibrotic phase (days 10-21 after BLM treatment) had no effect on lung fibrosis and TGF-ß production, although it significantly decreased CD4 T cell infiltration. Furthermore, depletion of neutrophils or CD4 T cells had no effect on BLM-induced lung fibrosis, suggesting the independence of profibrotic activity of the LTB4/BLT1 axis on BLT1-dependent lung recruitment of these two leukocytes. Finally, although BLT1 blockade had no effect on the recruitment and phenotype of macrophages in BLM-induced lung fibrosis, the LTB4/BLT1 axis could promote TGF-ß production by macrophages stimulated with BLM or supernatants from BLM-exposed airway epithelial cells in an autocrine manner, which further induced collagen secretion by lung fibroblasts. Collectively, our study demonstrates that the LTB4/BLT1 axis plays a critical role in acute injury phase to promote BLM-induced lung fibrosis, and it suggests that early interruption of the LTB4/BLT1 axis in some inflammatory diseases could prevent the later development of tissue fibrosis.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Neutrófilos/imunologia
Fibrose Pulmonar/imunologia
Receptores do Leucotrieno B4/metabolismo
[Mh] Termos MeSH secundário: Animais
Bleomicina
Linfócitos T CD4-Positivos/fisiologia
Álcoois Graxos/administração & dosagem
Glicóis/administração & dosagem
Inflamação
Interleucina-13/biossíntese
Interleucina-13/imunologia
Interleucina-17/biossíntese
Interleucina-17/imunologia
Pulmão/imunologia
Pulmão/patologia
Camundongos
Infiltração de Neutrófilos
Neutrófilos/fisiologia
Fibrose Pulmonar/induzido quimicamente
Fibrose Pulmonar/prevenção & controle
Receptores do Leucotrieno B4/deficiência
Receptores do Leucotrieno B4/genética
Transdução de Sinais
Fator de Crescimento Transformador beta/biossíntese
Fator de Crescimento Transformador beta/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Alcohols); 0 (Glycols); 0 (Interleukin-13); 0 (Interleukin-17); 0 (Ltb4r1 protein, mouse); 0 (Receptors, Leukotriene B4); 0 (Transforming Growth Factor beta); 11056-06-7 (Bleomycin); 119477-85-9 (U 75302)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1600465


  9 / 3714 MEDLINE  
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[PMID]:28044382
[Au] Autor:Xie H; Deng XY; Cheng CY; Yang KK; Wang YZ
[Ad] Endereço:Center for Degradable and Flame-Retardant Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu, 610064, China.
[Ti] Título:New Strategy to Access Dual-Stimuli-Responsive Triple-Shape-Memory Effect in a Non-overlapping Pattern.
[So] Source:Macromol Rapid Commun;38(4), 2017 Feb.
[Is] ISSN:1521-3927
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Multistimuli-responsive shape-memory polymers are highly desirable in various applications, and numerous modes have been developed in recent years. However, most of them need to reprogram before they are ready to respond to another stimulus while one is triggered. Here, a new strategy is developed to achieve dual-stimuli-responsive triple-shape memory with non-overlapping effect in one programming cycle. Here, a series of poly(l-lactide)-poly(tetramethylene oxide) glycol copolymers (PLA-PTMEG-A) is prepared by selected dangling photoresponsive anthracene moieties on the crystalline PTMEG backbone. The architectures of the copolymers are well-controlled in order to keep a good balance between the crystallinity of the soft segment and the mobility of the anthracene moieties. Thus, PLA-PTMEG-A's can respond to heat and light with non-overlapping effect. The thermally-induced shape-memory effect (TSME) is realized by the crystallization-melting transition of PTMEG soft segments, while the light-induced shape-memory effect (LSME) is achieved by the reversible photodimerization of anthracene groups. In view of the non-overlapping effect of TSME and LSME in the copolymers, a triple-shape-memory effect triggered by dual-stimuli is realized in one programming and recovery cycle.
[Mh] Termos MeSH primário: Glicóis/química
Poliésteres/química
[Mh] Termos MeSH secundário: Glicóis/síntese química
Estrutura Molecular
Poliésteres/síntese química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycols); 0 (Polyesters); 25190-06-1 (polytetramethylene glycol); 459TN2L5F5 (poly(lactide))
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1002/marc.201600664


  10 / 3714 MEDLINE  
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[PMID]:28012407
[Au] Autor:Chen MM; Cao H; Liu YY; Liu Y; Song FF; Chen JD; Zhang QQ; Yang WZ
[Ad] Endereço:Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China.
[Ti] Título:Sequential delivery of chlorhexidine acetate and bFGF from PLGA-glycol chitosan core-shell microspheres.
[So] Source:Colloids Surf B Biointerfaces;151:189-195, 2017 Mar 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Wound treatment should meet the challenge both of preventing infection and promoting wound healing. To design a sequential delivery system for wound healing, PLGA-glycol chitosan (GC) core-shell microspheres containing chlorhexidine acetate (CHA) at the GC shell and bFGF in the core of PLGA microspheres were fabricated using emulsion-solvent evaporation method. SEM showed that the microspheres were all spherical in shape with a smooth surface. The average size of PLGA-GC microspheres increased due to the GC coating on the surface. The results of release profiles and fluorescence images indicated that PLGA-GC microspheres had an ability to deliver drugs in sequence. The CHA was rapidly released, whereas the proteins presented a sustained release. The release behavior could be modulated by changing the GC amount. Antibacterial assay and cell proliferation tests suggested that the released CHA and bFGF retained their antimicrobial activity and bioactivity during preparation. The microspheres exhibited non-cytotoxicity against 3T3 cells and had a good biocompatibility. These results demonstrated that PLGA-GC core-shell microspheres could be a promising controlled release system of delivering drugs and proteins in sequence for wound healing.
[Mh] Termos MeSH primário: Quitosana/química
Clorexidina/administração & dosagem
Fator 2 de Crescimento de Fibroblastos/administração & dosagem
Glicóis/química
Ácido Láctico/química
Ácido Poliglicólico/química
[Mh] Termos MeSH secundário: Células 3T3
Animais
Antibacterianos/química
Materiais Biocompatíveis/química
Proliferação Celular
Clorexidina/química
Sistemas de Liberação de Medicamentos
Fator 2 de Crescimento de Fibroblastos/química
Camundongos
Microscopia Eletrônica de Varredura
Microesferas
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biocompatible Materials); 0 (Glycols); 0 (polylactic acid-polyglycolic acid copolymer); 103107-01-3 (Fibroblast Growth Factor 2); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); 9012-76-4 (Chitosan); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE



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