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[PMID]:28212199
[Au] Autor:Braham MY; Jedidi M; Chkirbene Y; Hmila I; ElKhal MC; Souguir MK; Ben Dhiab M
[Ad] Endereço:Author Affiliation: Department of Legal Medicine, Farhat Hached University Hospital.
[Ti] Título:Caregiver-Fabricated Illness in a Child: A Case Report of Three Siblings.
[So] Source:J Forensic Nurs;13(1):39-42, 2017 Jan/Mar.
[Is] ISSN:1939-3938
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Caregiver-fabricated illness in a child is a form of child maltreatment caused by a caregiver inducing a child's illness, leading to unnecessary and potentially harmful medical procedures and treatments. This condition can result in significant morbidity and mortality. We present the case of three siblings in Tunisia who were poisoned with chloralose by their own mother. The symptoms that the children presented with led to misdiagnoses, which resulted in the death of two of the children. Characteristics of the clinical presentation are articulated, followed by a discussion of the legal measures that apply to the offender and the role of physicians, nurses, and medicolegal experts involved in such a complex medical situation.
[Mh] Termos MeSH primário: Mães/psicologia
Síndrome de Munchausen Causada por Terceiro/psicologia
Irmãos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Cloralose/envenenamento
Feminino
Seres Humanos
Hipnóticos e Sedativos/envenenamento
Masculino
Síndrome de Munchausen Causada por Terceiro/legislação & jurisprudência
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 238BZ29MUE (Chloralose)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1097/JFN.0000000000000141


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[PMID]:27520434
[Au] Autor:Ross SE; Sperry ZJ; Mahar CM; Bruns TM
[Ad] Endereço:Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
[Ti] Título:Hysteretic behavior of bladder afferent neurons in response to changes in bladder pressure.
[So] Source:BMC Neurosci;17(1):57, 2016 Aug 12.
[Is] ISSN:1471-2202
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mechanosensitive afferents innervating the bladder increase their firing rate as the bladder fills and pressure rises. However, the relationship between afferent firing rates and intravesical pressure is not a simple linear one. Firing rate responses to pressure can differ depending on prior activity, demonstrating hysteresis in the system. Though this hysteresis has been commented on in published literature, it has not been quantified. RESULTS: Sixty-six bladder afferents recorded from sacral dorsal root ganglia in five alpha-chloralose anesthetized felines were identified based on their characteristic responses to pressure (correlation coefficient ≥ 0.2) during saline infusion (2 ml/min). For saline infusion trials, we calculated a maximum hysteresis ratio between the firing rate difference at each pressure and the overall firing rate range (or Hmax) of 0.86 ± 0.09 (mean ± standard deviation) and mean hysteresis ratio (or Hmean) of 0.52 ± 0.13 (n = 46 afferents). For isovolumetric trials in two experiments (n = 33 afferents) Hmax was 0.72 ± 0.14 and Hmean was 0.40 ± 0.14. CONCLUSIONS: A comprehensive state model that integrates these hysteresis parameters to determine the bladder state may improve upon existing neuroprostheses for bladder control.
[Mh] Termos MeSH primário: Neurônios Aferentes/fisiologia
Pressão
Bexiga Urinária/inervação
Bexiga Urinária/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Vias Aferentes/fisiologia
Anestésicos Intravenosos/farmacologia
Animais
Gatos
Cloralose/farmacologia
Gânglios Espinais/fisiologia
Masculino
Microeletrodos
Estimulação Física
Sacro
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 238BZ29MUE (Chloralose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160814
[St] Status:MEDLINE
[do] DOI:10.1186/s12868-016-0292-5


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[PMID]:27148970
[Au] Autor:Low LA; Bauer LC; Klaunberg BA
[Ad] Endereço:National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland, United States.
[Ti] Título:Comparing the Effects of Isoflurane and Alpha Chloralose upon Mouse Physiology.
[So] Source:PLoS One;11(5):e0154936, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Functional magnetic resonance imaging of mice requires that the physiology of the mouse (body temperature, respiration and heart rates, blood pH level) be maintained in order to prevent changes affecting the outcomes of functional scanning, namely blood oxygenation level dependent (BOLD) measures and cerebral blood flow (CBF). The anesthetic used to sedate mice for scanning can have major effects on physiology. While alpha chloralose has been commonly used for functional imaging of rats, its effects on physiology are not well characterized in the literature for any species. In this study, we anesthetized or sedated mice with isoflurane or alpha chloralose for up to two hours, and monitored physiological parameters and arterial blood gasses. We found that, when normal body temperature is maintained, breathing rates for both drugs decrease over the course of two hours. In addition, alpha chloralose causes a substantial drop in heart rate and blood pH with severe hypercapnia (elevated blood CO2) that is not seen in isoflurane-treated animals. We suggest that alpha chloralose does not maintain normal mouse physiology adequately for functional brain imaging outcome measures.
[Mh] Termos MeSH primário: Cloralose/efeitos adversos
Isoflurano/efeitos adversos
Fenômenos Fisiológicos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anestesia/efeitos adversos
Anestésicos/efeitos adversos
Animais
Artérias/efeitos dos fármacos
Artérias/fisiologia
Gasometria/métodos
Temperatura Corporal/efeitos dos fármacos
Encéfalo/fisiologia
Encéfalo/fisiopatologia
Mapeamento Encefálico/métodos
Circulação Cerebrovascular/efeitos dos fármacos
Circulação Cerebrovascular/fisiologia
Frequência Cardíaca/efeitos dos fármacos
Hipercapnia/induzido quimicamente
Imagem por Ressonância Magnética/métodos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Oxigênio/sangue
Respiração/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics); 238BZ29MUE (Chloralose); CYS9AKD70P (Isoflurane); S88TT14065 (Oxygen)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0154936


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[PMID]:26984200
[Au] Autor:Leporati M; Salomone A; Golè G; Vincenti M
[Ad] Endereço:Centro Regionale Antidoping e di Tossicologia "A. Bertinaria", regione Gonzole 10/1, 10043 Orbassano, TO, Italy.
[Ti] Título:Determination of Anticoagulant Rodenticides and α-Chloralose in Human Hair. Application to a Real Case.
[So] Source:J Anal Toxicol;40(4):277-85, 2016 May.
[Is] ISSN:1945-2403
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anticoagulant rodenticides are the largest group of poisons used to kill harmful rodents. Their fundamental mode of action consists in the inhibition of the vitamin K epoxide reductase, which causes blood-clotting alteration, ultimately leading to hemorrhagic events as the cause of death. In this study, we developed an UHPLC-MS-MS for the simultaneous determination of 10 anticoagulant hydroxycoumarine rodenticides, plus α-chloralose in human hair, with the scope of detecting potential trace of chronological poison exposure in clinical and forensic cases. The method was fully validated and applied to a case of intentional poisoning perpetrated by administration of difenacoum and α-chloralose to a 97-year-old woman, who was hospitalized because of severe symptoms, including drowsiness, convulsions, pallor and hematoma. Hair sample from the victim was segmentally analyzed. Difenacoum was detected in the proximal 3-cm hair segment at the concentration of 2.9 pg/mg. To our knowledge, this is the first study to report that exposure to difenacoum is detectable in real hair samples. The other target analyte found in the hair sample was α-chloralose, which was detected in the 0-3 cm segment at the concentration of 85 pg/mg. The two subsequent and consecutive segments (3-6 cm and 6-9 cm) showed only traces of difenacoum (below LOQ) and low but quantifiable concentrations of α-chloralose (29 and 6 pg/mg, respectively). Therefore, hair segmental analysis allowed us to conclude that the victim was repeatedly exposed to two poisons in the period corresponding to the first segment of hair.
[Mh] Termos MeSH primário: Anticoagulantes/análise
Cloralose/análise
Cabelo/química
Hipnóticos e Sedativos/análise
Rodenticidas/análise
[Mh] Termos MeSH secundário: 4-Hidroxicumarinas/análise
Idoso de 80 Anos ou mais
Cromatografia Líquida de Alta Pressão
Feminino
Seres Humanos
Reprodutibilidade dos Testes
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-Hydroxycoumarins); 0 (Anticoagulants); 0 (Hypnotics and Sedatives); 0 (Rodenticides); 238BZ29MUE (Chloralose); SBA3K9U26B (difenacoum)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160318
[St] Status:MEDLINE
[do] DOI:10.1093/jat/bkw019


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[PMID]:26077581
[Au] Autor:Baek K; Shim WH; Jeong J; Radhakrishnan H; Rosen BR; Boas D; Franceschini M; Biswal BB; Kim YR
[Ad] Endereço:Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, South Korea.
[Ti] Título:Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies.
[So] Source:Brain Struct Funct;221(5):2801-15, 2016 Jun.
[Is] ISSN:1863-2661
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The spontaneous cerebral hemodynamic fluctuations observed during the resting state have been frequently visualized using functional magnetic resonance imaging (rsfMRI). However, the neuronal populations and neuroelectric characteristics underlying the functional connectivity of cerebrohemodynamic activities are poorly understood. We investigated the characteristics of bi-hemispheric functional connectivity via electrophysiology and rsfMRI in the primary sensory cortex of rats anesthetized by α-chloralose. Unlike the evoked responses, the spontaneous electrophysiological activity was concentrated in the infragranular layers and could be classified into subtypes with distinctive current sources and sinks. Both neuroelectric and rsfMRI signals were interhemispherically correlated in a layer-specific manner, suggesting that there are independent neural inputs to infragranular and granular/supragranular layers. The majority of spontaneous electrophysiological activities were bilaterally paired with delays of up to ~50 ms between each pair. The variable interhemispheric delay implies the involvement of indirect, multi-neural pathways. Our findings demonstrated the diverse activity patterns of layer-specific electrophysiological substrates and suggest the recruitment of multiple, non-specific brain regions in construction of interhemispheric functional connectivity.
[Mh] Termos MeSH primário: Córtex Somatossensorial/fisiologia
Percepção do Tato/fisiologia
[Mh] Termos MeSH secundário: Anestésicos Intravenosos/administração & dosagem
Animais
Mapeamento Encefálico
Cloralose/administração & dosagem
Membro Anterior/fisiologia
Imagem por Ressonância Magnética
Masculino
Estimulação Física
Ratos
Ratos Sprague-Dawley
Córtex Somatossensorial/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 238BZ29MUE (Chloralose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150617
[St] Status:MEDLINE
[do] DOI:10.1007/s00429-015-1073-0


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[PMID]:26362515
[Au] Autor:Zemmama H; Rharrabti S; El Ayoubi Idrissi K; Aarab C; Aalouane R; Rammouz I
[Ad] Endereço:CHU Hassan II, hôpital Ibn Al Hassan, Ain Kadouss, Fès 30060, Maroc. Electronic address: charafa-malak@hotmail.com.
[Ti] Título:[On intoxication alphachloralose to addiction].
[Ti] Título:D'une intoxication à l'alphachloralose à l'addiction..
[So] Source:Presse Med;44(10):1082-4, 2015 Oct.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:fre
[Mh] Termos MeSH primário: Comportamento Aditivo/patologia
Cloralose/envenenamento
Transtornos Relacionados ao Uso de Substâncias/patologia
[Mh] Termos MeSH secundário: Cloralose/toxicidade
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
238BZ29MUE (Chloralose)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161209
[Lr] Data última revisão:
161209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150913
[St] Status:MEDLINE


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[PMID]:26146232
[Au] Autor:Osaka T
[Ad] Endereço:Department of Nutritional Science, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku 162-8636, Japan. Electronic address: osaka@nih.go.jp.
[Ti] Título:2-Deoxy-D-glucose-induced hypothermia in anesthetized rats: Lack of forebrain contribution and critical involvement of the rostral raphe/parapyramidal regions of the medulla oblongata.
[So] Source:Brain Res Bull;116:73-80, 2015 Jul.
[Is] ISSN:1873-2747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Systemic or central administration of 2-deoxy-d-glucose (2DG), a competitive inhibitor of glucose utilization, induces hypothermia in awake animals and humans. This response is mediated by the central nervous system, though the neural mechanism involved is largely unknown. In this study, I examined possible involvement of the forebrain, which contains the hypothalamic thermoregulatory center, and the medullary rostral raphe/parapyramidal regions (rRPa/PPy), which mediate hypoxia-induced heat-loss responses, in 2DG-induced hypothermia in urethane-chloralose-anesthetized, neuromuscularly blocked, artificially ventilated rats. The intravenous injection of 2DG (250mgkg(-1)) elicited an increase in tail skin temperature and decreases in body core temperature and the respiratory exchange ratio, though it did not induce any significant change in the metabolic rate. These results indicate that the hypothermic response was caused by an increase in heat loss, but not by a decrease in heat production and that it was accompanied by a decrease in carbohydrate utilization and/or an increase in lipid utilization as energy substrates. Complete surgical transection of the brainstem between the hypothalamus and the midbrain had no effect on the 2DG-induced hypothermic responses, suggesting that the hindbrain, but not the forebrain, was sufficient for the responses. However, pretreatment of the rRPa/PPy with the GABAA receptor blocker bicuculline methiodide, but not with vehicle saline, greatly attenuated the 2DG-induced responses, suggesting that the 2DG-induced hypothermia was mediated, at least in part, by GABAergic neurons in the hindbrain and activation of GABAA receptors on cutaneous sympathetic premotor neurons in the rRPa/PPy.
[Mh] Termos MeSH primário: Hipotermia/fisiopatologia
Prosencéfalo/fisiopatologia
Núcleos da Rafe/fisiopatologia
Termogênese
[Mh] Termos MeSH secundário: Anestésicos Intravenosos/farmacologia
Animais
Cloralose/farmacologia
Estado de Descerebração/fisiopatologia
Desoxiglucose
GABAérgicos/farmacologia
Masculino
Modelos Animais
Bloqueio Neuromuscular
Prosencéfalo/efeitos dos fármacos
Núcleos da Rafe/efeitos dos fármacos
Ratos Wistar
Receptores de GABA-A/metabolismo
Fluxo Sanguíneo Regional/efeitos dos fármacos
Fluxo Sanguíneo Regional/fisiologia
Respiração Artificial
Cauda/fisiopatologia
Termogênese/efeitos dos fármacos
Uretana/farmacologia
Ácido gama-Aminobutírico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (GABA Agents); 0 (Receptors, GABA-A); 238BZ29MUE (Chloralose); 3IN71E75Z5 (Urethane); 56-12-2 (gamma-Aminobutyric Acid); 9G2MP84A8W (Deoxyglucose)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150729
[Lr] Data última revisão:
150729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150707
[St] Status:MEDLINE


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[PMID]:25757750
[Au] Autor:Zhao L; Nowak TS
[Ad] Endereço:Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
[Ti] Título:Preconditioning cortical lesions reduce the incidence of peri-infarct depolarizations during focal ischemia in the Spontaneously Hypertensive Rat: interaction with prior anesthesia and the impact of hyperglycemia.
[So] Source:J Cereb Blood Flow Metab;35(7):1181-90, 2015 Jul.
[Is] ISSN:1559-7016
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The relationship between peri-infarct depolarizations (PIDs) and infarction was investigated in a model of preconditioning by cortical freeze lesions (cryogenic lesions, CL) in the Spontaneously Hypertensive Rat. Small (< 5 mm(3)) lesions produced 24 hours before permanent focal ischemia were protective, without impacting baseline cerebral blood flow (CBF) and metabolism. Prior CL reduced infarct volume, associated with improved penumbral CBF as previously showed for ischemic preconditioning. The brief initial procedure avoided sham effects on infarct volume after subsequent occlusion under brief anesthesia. However, under prolonged isoflurane anesthesia for perfusion monitoring both sham and CL rats showed reduced PID incidence relative to naive animals. This anesthesia effect could be eliminated by using α-chloralose during perfusion imaging. As an additional methodological concern, blood glucose was frequently elevated at the time of the second surgery, reflecting buprenorphine-induced pica and other undefined mechanisms. Even modest hyperglycemia (>10 mmol/L) reduced PID incidence. In normoglycemic animals CL preconditioning reduced PID number by 50%, demonstrating associated effects on PID incidence, penumbral perfusion, and infarct progression. Hyperglycemia suppressed PIDs without affecting the relationship between CBF and infarction. This suggests that the primary effect of preconditioning is to improve penumbral perfusion, which in turn impacts PID incidence and infarct size.
[Mh] Termos MeSH primário: Córtex Cerebelar/patologia
Infarto Cerebral/complicações
Infarto Cerebral/patologia
Circulação Cerebrovascular
Depressão Alastrante da Atividade Elétrica Cortical
Congelamento
Hiperglicemia/complicações
[Mh] Termos MeSH secundário: Anestesia
Anestésicos Inalatórios/uso terapêutico
Anestésicos Intravenosos/uso terapêutico
Animais
Córtex Cerebelar/irrigação sanguínea
Córtex Cerebelar/fisiopatologia
Infarto Cerebral/etiologia
Infarto Cerebral/fisiopatologia
Cloralose/uso terapêutico
Modelos Animais de Doenças
Precondicionamento Isquêmico
Isoflurano/uso terapêutico
Masculino
Ratos Endogâmicos SHR
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Anesthetics, Intravenous); 238BZ29MUE (Chloralose); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:160701
[Lr] Data última revisão:
160701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150312
[St] Status:MEDLINE
[do] DOI:10.1038/jcbfm.2015.37


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[PMID]:25742867
[Au] Autor:Alkan S; Telli FÇ; Salman Y; Astley ST
[Ad] Endereço:Ege University, Faculty of Science, Department of Chemistry, Bornova, Izmir 35100, Turkey.
[Ti] Título:Synthesis of novel Schiff base ligands from gluco- and galactochloraloses for the Cu(II) catalyzed asymmetric Henry reaction.
[So] Source:Carbohydr Res;407:97-103, 2015 Apr 30.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A series of chiral Schiff base ligands has been prepared using aminochloralose derivatives of glucose and galactose. These ligands were used as catalysts in the asymmetric Henry reaction in the presence of Cu(II) ions giving yields of up to 95%. An interesting solvent dependency on enantiomeric control was observed with the best enantiomeric excesses (up to 91%) being obtained in the presence of water.
[Mh] Termos MeSH primário: Cloralose/química
Cobre/química
Bases de Schiff/síntese química
[Mh] Termos MeSH secundário: Catálise
Cloralose/síntese química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Schiff Bases); 238BZ29MUE (Chloralose); 789U1901C5 (Copper)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150406
[Lr] Data última revisão:
150406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150307
[St] Status:MEDLINE


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[PMID]:25730758
[Au] Autor:Beam DM; Neto-Neves EM; Stubblefield WB; Alves NJ; Tune JD; Kline JA
[Ad] Endereço:Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
[Ti] Título:Comparison of isoflurane and α-chloralose in an anesthetized swine model of acute pulmonary embolism producing right ventricular dysfunction.
[So] Source:Comp Med;65(1):54-61, 2015 Feb.
[Is] ISSN:1532-0820
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulmonary embolism (PE) is a leading cause of sudden cardiac death, and a model is needed for testing potential treatments. In developing a model, we compared the hemodynamic effects of isoflurane and α-chloralose in an acute swine model of PE because the choice of anesthesia will likely affect the cardiovascular responses of an animal to PE. At baseline, swine that received α-chloralose (n = 6) had a lower heart rate and cardiac output and higher SpO2, end-tidal CO2, and mean arterial pressure than did those given isoflurane (n = 9). After PE induction, swine given α-chloralose compared with isoflurane exhibited a lower heart rate (63 ± 10 compared with 116 ± 15 bpm) and peripheral arterial pressure (52 ± 12 compared with 61 ± 12 mm Hg); higher SpO2 (98% ± 3% compared with 95% ± 1%), end-tidal CO2 (35 ± 4 compared with 32 ± 5), and systolic blood pressure (121 ± 8 compared with 104 ± 20 mm Hg); and equivalent right ventricular:left ventricular ratios (1.32 ± 0.50 compared with 1.23 ± 0.19) and troponin I mean values (0.09 ± 0.07 ng/mL compared with 0.09 ± 0.06 ng/mL). Isoflurane was associated with widely variable fibrinogen and activated partial thromboplastin time. Intraexperiment mortality was 0 of 6 animals for α-chloralose and 2 of 9 swine for isoflurane. All swine anesthetized with α-chloralose survived with sustained pulmonary hypertension, RV-dilation-associated cardiac injury without the confounding vasodilatory or coagulatory effects of isoflurane. These data demonstrate the physiologic advantages of α-chloralose over isoflurane for anesthesia in a swine model of severe submassive PE.
[Mh] Termos MeSH primário: Anestesia/veterinária
Anestésicos Inalatórios/farmacologia
Modelos Animais de Doenças
Hemodinâmica/efeitos dos fármacos
Embolia Pulmonar/complicações
Embolia Pulmonar/fisiopatologia
Disfunção Ventricular Direita/etiologia
[Mh] Termos MeSH secundário: Anestesia/mortalidade
Animais
Biomarcadores/metabolismo
Pressão Sanguínea/efeitos dos fármacos
Débito Cardíaco/efeitos dos fármacos
Cloralose/farmacologia
Frequência Cardíaca/efeitos dos fármacos
Isoflurano/farmacologia
Suínos
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Biomarkers); 238BZ29MUE (Chloralose); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150303
[St] Status:MEDLINE



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