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Pesquisa : D02.033.455.250.700.685 [Categoria DeCS]
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[PMID]:29244868
[Au] Autor:Li X; Zhao Y; Wang K; Wang L; Yang X; Zhu S
[Ad] Endereço:Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release.
[So] Source:PLoS One;12(12):e0189778, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing ß-cyclodextrin (ß-CD) (pHEMA/MMA/ß-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/ß-CD copolymers containing different ratios of ß-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization. The polymers had high transmittance at visible wavelengths and good biocompatibility with mouse connective tissue fibroblasts. Drug loading and release studies demonstrated that introducing ß-CD into hydrogels increased loading efficiency and achieved the sustained release of the drug. Administering ß-CD via hydrogels increased the equilibrium swelling ratio, elastic modulus and tensile strength. In addition, ß-CD increased the hydrophilicity of the hydrogels, resulting in a lower water contact angle and higher cellular adhesion to the hydrogels. In summary, pHEMA/MMA/ß-CD hydrogels show great potential as IOL biomaterials that are capable of maintaining the sustained release of anti-inflammatory drugs after cataract surgery.
[Mh] Termos MeSH primário: Extração de Catarata
Catarata/tratamento farmacológico
Ciclodextrinas/uso terapêutico
Dexametasona/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Materiais Biocompatíveis/química
Materiais Biocompatíveis/uso terapêutico
Catarata/patologia
Linhagem Celular
Ciclodextrinas/química
Dexametasona/química
Liberação Controlada de Fármacos
Olho/citologia
Olho/efeitos dos fármacos
Seres Humanos
Hidrogéis/química
Hidrogéis/uso terapêutico
Lentes Intraoculares
Metilmetacrilatos/química
Metilmetacrilatos/uso terapêutico
Camundongos
Poli-Hidroxietil Metacrilato/química
Poli-Hidroxietil Metacrilato/uso terapêutico
Polímeros/química
Polímeros/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Cyclodextrins); 0 (Hydrogels); 0 (Methylmethacrylates); 0 (Polymers); 25249-16-5 (Polyhydroxyethyl Methacrylate); 26355-01-1 (HTR composite); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189778


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[PMID]:28235457
[Au] Autor:Elkak A; Hamade A; Bereli N; Armutcu C; Denizli A
[Ad] Endereço:Laboratorire de Valorisation des Ressources Naturelles et Produits de Santé (LVRNPS), Doctoral School of Sciences and Technology, Lebanese University, Rafic Hariri University Campus, P.O. BOX 14/6573, Hadath, Lebanon. Electronic address: aelkak@ul.edu.lb.
[Ti] Título:Synthesis of hydroxyethyl-methacrylate-(L)-histidine methyl ester cryogels. Application on the separation of bovine immunoglobulin G.
[So] Source:Anal Biochem;525:1-7, 2017 May 15.
[Is] ISSN:1096-0309
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study cryogels based 2-hydroxyethyl methacrylate (HEMA) functionalized with N-methacryloyl-L-histidine methyl ester (MAH) were synthesized and used for the adsorption and separation of bovine IgG. Two series of cryogels functionalized with 5 and 10 mg of MAH as pseudobioaffinity ligand were prepared and characterized by swelling test, FTIR and SEM analysis. The adsorption efficiency of the bovine immunoglobulin into cryogels is discussed with respect to the following chromatographic parameters: pH, flow rate, initial IgG concentration, adsorption time and ionic strength. Our results show good adsorption of bovine immunoglobulin under mild separation conditions at pH 7.4. The maximum binding capacity was determined (32.4 mg/g of cryogel) and demonstrates the efficiency of the used cryogels. This efficacy is clearly seen upon increasing the maximum binding capacity from 23.2 mg (obtained with cryogels with 5 mg MAH) to 32.4 mg/g (for cryogel with 10 mg MAH ligand concentration). The purity of separated fractions was evaluated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Together our observations highlights poly (HEMA-MAH) as an efficient adsorbent for bovine immunoglobulins G separation.
[Mh] Termos MeSH primário: Criogéis/síntese química
Histidina/análogos & derivados
Imunoglobulina G/isolamento & purificação
Poli-Hidroxietil Metacrilato/química
[Mh] Termos MeSH secundário: Adsorção
Animais
Bovinos
Cromatografia de Afinidade/métodos
Eletroforese em Gel de Poliacrilamida/métodos
Histidina/química
Concentração de Íons de Hidrogênio
Imunoglobulina G/química
Concentração Osmolar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryogels); 0 (Immunoglobulin G); 25249-16-5 (Polyhydroxyethyl Methacrylate); 4QD397987E (Histidine); 9IHZ1723UE (histidine methyl ester)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


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[PMID]:28106508
[Au] Autor:Khayat A; Monteiro N; Smith EE; Pagni S; Zhang W; Khademhosseini A; Yelick PC
[Ad] Endereço:1 Tufts University School of Dental Medicine, Boston, MA, USA.
[Ti] Título:GelMA-Encapsulated hDPSCs and HUVECs for Dental Pulp Regeneration.
[So] Source:J Dent Res;96(2):192-199, 2017 Feb.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulpal revascularization is commonly used in the dental clinic to obtain apical closure of immature permanent teeth with thin dentinal walls. Although sometimes successful, stimulating bleeding from the periapical area of the tooth can be challenging and in turn may deleteriously affect tooth root maturation. Our objective here was to define reliable methods to regenerate pulp-like tissues in tooth root segments (RSs). G1 RSs were injected with human dental pulp stem cells (hDPSCs) and human umbilical vein endothelial cells (HUVECs) encapsulated in 5% gelatin methacrylate (GelMA) hydrogel. G2 RSs injected with acellular GelMA alone, and G3 empty RSs were used as controls. White mineral trioxide aggregate was used to seal one end of the tooth root segment, while the other was left open. Samples were cultured in vitro in osteogenic media (OM) for 13 d and then implanted subcutaneously in nude rats for 4 and 8 wk. At least 5 sample replicates were used for each experimental group. Analyses of harvested samples found that robust pulp-like tissues formed in G1, GelMA encapsulated hDPSC/HUVEC-filled RSs, and less cellularized host cell-derived pulp-like tissue was observed in the G2 acellular GelMA and G3 empty RS groups. Of importance, only the G1, hDPSC/HUVEC-encapsulated GelMA constructs formed pulp cells that attached to the inner dentin surface of the RS and infiltrated into the dentin tubules. Immunofluorescent (IF) histochemical analysis showed that GelMA supported hDPSC/HUVEC cell attachment and proliferation and also provided attachment for infiltrating host cells. Human cell-seeded GelMA hydrogels promoted the establishment of well-organized neovasculature formation. In contrast, acellular GelMA and empty RS constructs supported the formation of less organized host-derived vasculature formation. Together, these results identify GelMA hydrogel combined with hDPSC/HUVECs as a promising new clinically relevant pulpal revascularization treatment to regenerate human dental pulp tissues.
[Mh] Termos MeSH primário: Regeneração Óssea/fisiologia
Cápsulas/uso terapêutico
Polpa Dentária/crescimento & desenvolvimento
Células Endoteliais da Veia Umbilical Humana/transplante
Hidrogéis/uso terapêutico
Transplante de Células-Tronco/métodos
Células-Tronco/citologia
[Mh] Termos MeSH secundário: Animais
Feminino
Células Endoteliais da Veia Umbilical Humana/fisiologia
Seres Humanos
Poli-Hidroxietil Metacrilato/uso terapêutico
Ratos
Ratos Nus
Engenharia Tecidual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsules); 0 (Hydrogels); 25249-16-5 (Polyhydroxyethyl Methacrylate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1177/0022034516682005


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[PMID]:27666643
[Au] Autor:Oubagha N; Lemlikchi W; Sharrock P; Fiallo M; Mecherri MO
[Ad] Endereço:Université Mouloud Mammeri Laboratoire LCAGC, Tizi-Ouzou, 15000, Algeria. Electronic address: oubagha.noura@gmail.com.
[Ti] Título:Hydroxyapatite precipitation with Hydron Blue dye.
[So] Source:J Environ Manage;203(Pt 2):807-810, 2017 Dec 01.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Calcium phosphate, in the form of amorphous hydroxyapatite, precipitates out of neutral water solutions containing calcium and phosphate ions in the form of small agglomerates of 18 µm average size. When Hydron Blue dye (HB) is added, the insoluble particles gradually agglomerate further to 50 µm sizes. However, the removal capacity of hydroxyapatite for the dye is increased when the calcium phosphate nucleates and forms in the presence of dye. When coprecipitates form, the particules average 20 µm size and contain up to 60% organic matter. Nascent calcium phosphate particles have strong capacity for Hydron Blue dye removal. Thus smaller calcium phosphate particles increase the amount of dye molecules in water pollution control.
[Mh] Termos MeSH primário: Durapatita
Hidrogéis
Poli-Hidroxietil Metacrilato/análogos & derivados
[Mh] Termos MeSH secundário: Cálcio
Precipitação Química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrogels); 0 (polyhydroxyethyl methacrylate hydrogels); 25249-16-5 (Polyhydroxyethyl Methacrylate); 91D9GV0Z28 (Durapatite); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


  5 / 1251 MEDLINE  
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[PMID]:27977839
[Au] Autor:Orban MW; Haddock LJ
[Ti] Título:MIRAgel Buckle Extrusion With Preseptal Cellulitis and Erosion Through the Eyelid Skin.
[So] Source:Ophthalmic Surg Lasers Imaging Retina;47(12):1147-1150, 2016 Dec 01.
[Is] ISSN:2325-8179
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:MIRAgel (MIRA, Waltham, MA) scleral buckle material was initially developed in the 1980s as an alternative to more traditional silicone buckles. Long-term follow-up has demonstrated complications necessitating removal due to unanticipated hydrolytic degeneration of the exoplant. Material expansion and fragmentation have led to pain, limited extraocular motility, ocular masses, infection, and eventual extrusion. Complications occur later than in other materials; most patients need removal an average of 7 years to 13 years after implantation. This case describes a previously not reported case of MIRAgel scleral buckle extrusion complicated by preseptal cellulitis and complete erosion of the material through the inferior eyelid and extrusion through the skin. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:1147-1150.].
[Mh] Termos MeSH primário: Celulite (Flegmão)/etiologia
Doenças Palpebrais/etiologia
Poli-Hidroxietil Metacrilato/análogos & derivados
Complicações Pós-Operatórias/etiologia
Descolamento Retiniano/cirurgia
Recurvamento da Esclera/efeitos adversos
[Mh] Termos MeSH secundário: Celulite (Flegmão)/diagnóstico
Celulite (Flegmão)/cirurgia
Doenças Palpebrais/diagnóstico
Doenças Palpebrais/cirurgia
Seres Humanos
Masculino
Meia-Idade
Poli-Hidroxietil Metacrilato/efeitos adversos
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/cirurgia
Reoperação
Recurvamento da Esclera/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
116788-62-6 (Miragel); 25249-16-5 (Polyhydroxyethyl Methacrylate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.3928/23258160-20161130-10


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[PMID]:27895484
[Au] Autor:Yoon JY; Yang KJ; Park SN; Kim DK; Kim JD
[Ad] Endereço:Department of Chemical and Biomolecular Engineering, BK 21 Plus Program, Korea Advanced Institute of Science and Technology, Guseong-Dong, Yuseong-Gu, Daejeon.
[Ti] Título:The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy.
[So] Source:Int J Nanomedicine;11:6123-6134, 2016.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Dexamethasone (Dex)-loaded PHEA-g-C18-Arg8 (PCA) nanoparticles (PCA/Dex) were developed for the delivery of genes to determine the synergistic effect of Dex on gene expression. The cationic PCA nanoparticles were self-assembled to create cationic micelles containing an octadecylamine (C18) core with Dex and an arginine 8 (Arg8) peptide shell for electrostatic complexation with nucleic acids (connexin 26 [ ] siRNA, green fluorescent protein [GFP] DNA or brain-derived neurotrophic factor [BDNF] pDNA). The PCA/Dex nanoparticles conjugated with Arg8, a cell-penetrating peptide that enhances permeability through a round window membrane in the inner ear for gene delivery, exhibited high uptake efficiency in HEI-OC1 cells. This potential carrier co-delivering Dex and the gene into inner ear cells has a diameter of 120-140 nm and a zeta potential of 20-25 mV. Different types of genes were complexed with the Dex-loaded PCA nanoparticle (PCA/Dex/gene) for gene expression to induce additional anti-inflammatory effects. PCA/Dex showed mildly increased expression of GFP and lower mRNA expression of inflammatory cytokines (IL1b, IL12, and INFr) than did Dex-free PCA nanoparticles and Lipofectamine reagent in HEI-OC1 cells. In addition, after loading siRNA onto the surface of PCA/Dex, gene expression was downregulated according to real-time polymerase chain reaction for 24 h, compared with that using Lipofectamine reagent. After loading BDNF DNA into PCA/Dex, increased expression of BDNF was observed for 30 h, and its signaling pathway resulted in an increase in phosphorylation of Akt, observed by Western blotting. Thus, Dex within PCA/Dex/gene nanoparticles created an anti-inflammatory effect and enhanced gene expression.
[Mh] Termos MeSH primário: Peptídeos Penetradores de Células/farmacocinética
Dexametasona/farmacocinética
Técnicas de Transferência de Genes
Nanopartículas/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Fator Neurotrófico Derivado do Encéfalo/genética
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Linhagem Celular
Peptídeos Penetradores de Células/administração & dosagem
Conexinas/genética
Orelha Interna/citologia
Terapia Genética/métodos
Proteínas de Fluorescência Verde/genética
Lipídeos
Camundongos
Micelas
Nanopartículas/química
Poli-Hidroxietil Metacrilato/análogos & derivados
Poli-Hidroxietil Metacrilato/química
RNA Interferente Pequeno/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Janela da Cóclea/efeitos dos fármacos
Janela da Cóclea/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Cell-Penetrating Peptides); 0 (Connexins); 0 (Gjb2 protein, mouse); 0 (Lipids); 0 (Lipofectamine); 0 (Micelles); 0 (RNA, Small Interfering); 147336-22-9 (Green Fluorescent Proteins); 25249-16-5 (Polyhydroxyethyl Methacrylate); 26022-14-0 (poly(2-hydroxyethyl acrylate)); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE


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[PMID]:27611883
[Au] Autor:Khadka S; El Rassi Z
[Ad] Endereço:Department of Chemistry, Oklahoma State University, Stillwater, OK, USA.
[Ti] Título:Postpolymerization modification of a hydroxy monolith precursor. Part I. Epoxy alkane and octadecyl isocyanate modified poly (hydroxyethyl methacrylate-co-pentaerythritol triacrylate) monolithic capillary columns for reversed-phase capillary electrochromatography.
[So] Source:Electrophoresis;37(23-24):3160-3171, 2016 12.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A novel precursor monolithic capillary column referred to as "hydroxy monolith" or OHM was prepared by the in situ copolymerization of hydroxyethylmethacrylate (HEMA) with pentaerythritol triacrylate (PETA) yielding the neutral poly(HEMA-co-PETA) monolith. The neutral precursor OHM capillary thus obtained was subjected to postpolymerization modifications of the hydroxyl functional groups present on its surface with 1,2-epoxyalkanes catalyzed by boron trifluoride (BF ) ultimately providing Epoxy OHM C-m capillary column at varying alkyl chain lengths where m = 8, 12, 14, and 16 for RP-CEC. Also, the same precursor OHM was grafted with octadecyl isocyanate yielding Isocyanato OHM C-18 column to provide an insight into the effect of the nature of the linkage to the surface hydroxyl groups of the OHM precursor. While the epoxide reaction leaves on the surface of the OHM precursor hydroxy-ether linkages, the isocyanato reaction leaves carbamate linkages on the same surface of the OHM precursor. This study revealed that changing the alkyl chain length resulted in changing the column phase ratio (Ï•) and also the solute distribution constant (K). While increasing the surface alkyl chain length increased steeply the solute hydrophobic selectivity, i.e. methylene group selectivity, the nature of the ligand linkage produced different retention for the same solutes and affected the selectivity of slightly polar solutes. The various monoliths proved very useful for RP-CEC of different small solutes at varying polarity over a wide range of mobile phase composition.
[Mh] Termos MeSH primário: Acrilatos/química
Eletrocromatografia Capilar/instrumentação
Cromatografia de Fase Reversa/instrumentação
Compostos de Epóxi/química
Isocianatos/química
Poli-Hidroxietil Metacrilato/química
Propilenoglicóis/química
[Mh] Termos MeSH secundário: Alcanos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Alkanes); 0 (Epoxy Compounds); 0 (Isocyanates); 0 (Propylene Glycols); 25249-16-5 (Polyhydroxyethyl Methacrylate); PJJ1161ULF (pentaerythrityl triacrylate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600321


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[PMID]:27611813
[Au] Autor:Khadka S; El Rassi Z
[Ad] Endereço:Department of Chemistry, Oklahoma State University, Stillwater, OK, USA.
[Ti] Título:Postpolymerization modification of a hydroxy monolith precursor. Part II. Epoxy biphenyl modified poly (hydroxyethyl methacrylate-co-pentaerythritol triacrylate) monolithic capillary columns for reversed-phase capillary electrochromatography based on π-π and hydrophobic interactions.
[So] Source:Electrophoresis;37(23-24):3172-3177, 2016 12.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this second part of the series of investigations involving the postpolymerization modification of a hydroxy monolith (OHM) capillary column, the surface hydroxyl groups were reacted with epoxy biphenyl thus yielding the so-called Biphenyl OHM capillary column. The modification involved the epoxy ring opening of the 2-biphenylyl glycidyl ether catalyzed by BF and its subsequent reaction with the hydroxyl groups on the OHM precursor surface. The Biphenyl OHM capillary column thus obtained exhibited the typical reversed phase behavior by primarily hydrophobic interactions vis-à-vis the homologous series of alkyl benzenes and in addition by π-π interactions toward nitroalkane homologous series via their π-electron rich nitro groups. This dual retention mechanism was very distinctly observed with a set of PAH solutes in the sense that the k values of the PAH solutes were comparable to those obtained on a more non polar stationary phase, namely the Epoxy OHM C-16 reported in the preceding article. Other aromatic solutes showed the dual retention mechanism on the Biphenyl OHM capillary including phenols, anilines derivatives, and phenoxy acid herbicides. The Biphenyl OHM capillary exhibited good reproducibility from run-to-run, day-to-day, and column-to-column.
[Mh] Termos MeSH primário: Acrilatos/química
Compostos de Bifenilo/química
Eletrocromatografia Capilar/instrumentação
Cromatografia de Fase Reversa/instrumentação
Compostos de Epóxi/química
Poli-Hidroxietil Metacrilato/química
Propilenoglicóis/química
[Mh] Termos MeSH secundário: Compostos de Anilina/análise
Compostos de Anilina/química
Interações Hidrofóbicas e Hidrofílicas
Fenóis/análise
Fenóis/química
Hidrocarbonetos Aromáticos Policíclicos/análise
Hidrocarbonetos Aromáticos Policíclicos/química
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Aniline Compounds); 0 (Biphenyl Compounds); 0 (Epoxy Compounds); 0 (Phenols); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Propylene Glycols); 25249-16-5 (Polyhydroxyethyl Methacrylate); 2L9GJK6MGN (diphenyl); PJJ1161ULF (pentaerythrityl triacrylate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600325


  9 / 1251 MEDLINE  
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[PMID]:27566076
[Au] Autor:Kim S; Hwang Y; Kashif M; Jeong D; Kim G
[Ad] Endereço:Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
[Ti] Título:Evaluation of Bone Regeneration on Polyhydroxyethyl-polymethyl Methacrylate Membrane in a Rabbit Calvarial Defect Model.
[So] Source:In Vivo;30(5):587-91, 2016 09-10.
[Is] ISSN:1791-7549
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:This study was conducted to evaluate the capacity of guiding bone regeneration of polyhydroxyethyl-polymethyl methacrylate (PHEMA-PMMA) membrane as a guided tissue regeneration membrane for bone defects. Two 8-mm diameter transosseous round defects were made at the parietal bone of 18 New Zealand White rabbits. Defects were covered with or without PHEMA-PMMA membrane. Radiological and histological evaluation revealed that the bone tissue over the defect was more regenerated with time in both groups. However, there was significantly more bone regeneration at 8 weeks in the experimental group than the control group (p<0.05). There was no sign of membrane degradation or tissue inflammation and no invasion of muscle and fibrous tissue into defects. PHEMA-PMMA is a potential material for guided tissue regeneration membrane as it induces no adverse tissue reaction and effectively supports selective bone regeneration.
[Mh] Termos MeSH primário: Regeneração Óssea
Poli-Hidroxietil Metacrilato/administração & dosagem
Polimetil Metacrilato/administração & dosagem
Crânio/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Substitutos Ósseos/administração & dosagem
Substitutos Ósseos/efeitos adversos
Modelos Animais de Doenças
Regeneração Tecidual Guiada
Seres Humanos
Membranas Artificiais
Poli-Hidroxietil Metacrilato/efeitos adversos
Polimetil Metacrilato/efeitos adversos
Coelhos
Crânio/patologia
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Substitutes); 0 (Membranes, Artificial); 25249-16-5 (Polyhydroxyethyl Methacrylate); 9011-14-7 (Polymethyl Methacrylate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE


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Fotocópia
[PMID]:27455744
[Au] Autor:Bach LG; Cao XT; Islam MR; Jeong YT; Kim JS; Lim KT
[Ti] Título:Synthesis and Characterization of Multiwalled Carbon Nanotubes/Poly(HEMA-co-MMA) by Utilizing Click Chemistry.
[So] Source:J Nanosci Nanotechnol;16(3):2975-8, 2016 Mar.
[Is] ISSN:1533-4880
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hybrid material consisting of multi walled carbon nanotubes (MWNTs) and poly(2-hydroxyethylmethacrylate-co-methylmethacrylate) [poly(HEMA-co-MMA)] was synthesized by a combination of RAFT and Click chemistry. In the primary stage, the copolymer poly(HEMA-co-MMA) was prepared by applying RAFT technique. Alkynyl side groups were incorporated onto the poly(HEMA-co-MMA) backbone by esterification reaction. Then, MWNTs-N3 was prepared by treating MWNTs with 4-azidobutylamine. The click coupling reaction between azide-functionalized MWNTs (MWNTs-N3) and the alkyne-functionalized random copolymer ((HEMA-co-MMA)-Alkyne) with the Cu(I)-catalyzed [3+2] Huisgen cycloaddition afforded the hybrid compound. The structure and properties of poly(MMA-co-HEMA)-g-MWNTs were investigated by FT-IR, EDX and TGA measurements. The copolymer brushes were observed to be immobilized onto the functionalized MWNTs by SEM and TEM analysis.
[Mh] Termos MeSH primário: Química Click
Metilmetacrilatos/química
Nanotubos de Carbono
Poli-Hidroxietil Metacrilato/química
[Mh] Termos MeSH secundário: Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Espectroscopia de Prótons por Ressonância Magnética
Espectroscopia de Infravermelho com Transformada de Fourier
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylmethacrylates); 0 (Nanotubes, Carbon); 25249-16-5 (Polyhydroxyethyl Methacrylate); 26355-01-1 (HTR composite)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE



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