Base de dados : MEDLINE
Pesquisa : D02.033.755 [Categoria DeCS]
Referências encontradas : 2088 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 209 ir para página                         

  1 / 2088 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29430906
[Au] Autor:Martynova NA; Gorokhova LG
[Ti] Título:[Toxicological characteristics of the cinnamic].
[So] Source:Gig Sanit;95(8):779-81, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The toxic properties of the cinnamic alcohol with an aim of its hygienic rating are studied. DL for male rats, male and female mice are respectively 3300, 3000 and 2700 mg/kg. It refers to the substances of hazard class 3. The clinical picture of acute poisoning was characterized by the general depression, muscle relaxation, disorder of the movement coordination, decrease in body temperature and death in the first and the second days after the poisoning. The differences in sex and species sensitivity of the animals to the substance are not observed: the rates of species differences and sex sensitivity are ~1. Single and repeated (10 days) inhalation of the vapors of the cinnamic alcohol at the greatest possible saturation neither cause the death of mice no signs of toxicity. It has a weak ability to cumulation: the cumulation coefficient is 5.4. It has no local irritating action to the skin. Skin-resorptive and sensitizing effects are not revealed. It has a weak irritating effect on the mucous membranes of the eyes. In the subacute experiment after the introduction of the substance into the stomach in a total dose equal to 5.2 DL we noted the lag of the experimental animals in body weight gain from the control ones, the increase in the activity of y-glutamyl transpeptidase and transaminases in serum. In the peripheral blood the decrease in hemoglobin, erythrocytes and eosinophils count is revealed. The threshold of the acute inhalation effect is 140 mg/m (by the reduction in the number of erythrocytes and hemoglobin in peripheral blood). Tentative safe level of the exposure to the cinnamic alcohol in the air of the working zone is 5 mg/m (vapors).
[Mh] Termos MeSH primário: Indústria Farmacêutica/normas
Exposição Ocupacional
Saúde do Trabalhador/normas
Propanóis
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Substâncias Perigosas/química
Substâncias Perigosas/toxicidade
Concentração Máxima Permitida
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/normas
Propanóis/química
Propanóis/toxicidade
Ratos
Testes de Toxicidade/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Substances); 0 (Propanols); SS8YOP444F (cinnamyl alcohol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29233651
[Au] Autor:Gong H; Weinstein DS; Lu Z; Duan JJ; Stachura S; Haque L; Karmakar A; Hemagiri H; Raut DK; Gupta AK; Khan J; Camac D; Sack JS; Pudzianowski A; Wu DR; Yarde M; Shen DR; Borowski V; Xie JH; Sun H; D'Arienzo C; Dabros M; Galella MA; Wang F; Weigelt CA; Zhao Q; Foster W; Somerville JE; Salter-Cid LM; Barrish JC; Carter PH; Dhar TGM
[Ad] Endereço:Bristol-Myers Squibb, Research and Development, Princeton, NJ 08543-4000, United States.
[Ti] Título:Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
[So] Source:Bioorg Med Chem Lett;28(2):85-93, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists. However, a majority of these compounds showed potent activity against pregnane X receptor (PXR) and modest activity against liver X receptor α (LXRα). Structure-based drug design (SBDD) led to the identification of benzothiazine and tetrahydroquinoline sulfonamide analogs which completely dialed out LXRα activity and were less potent at PXR. Pharmacodynamic (PD) data for compound 35 in an IL-23 induced IL-17 mouse model is discussed along with the implications of a high Y in the PXR assay for long term preclinical pharmacokinetic (PK) studies.
[Mh] Termos MeSH primário: Compostos Bicíclicos com Pontes/farmacologia
Desenho de Drogas
Propanóis/farmacologia
Receptores do Ácido Retinoico/agonistas
Receptores de Esteroides/agonistas
Sulfonamidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Compostos Bicíclicos com Pontes/síntese química
Compostos Bicíclicos com Pontes/química
Cristalografia por Raios X
Relação Dose-Resposta a Droga
Seres Humanos
Receptores X do Fígado/agonistas
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Modelos Moleculares
Estrutura Molecular
Propanóis/síntese química
Propanóis/química
Relação Estrutura-Atividade
Sulfonamidas/síntese química
Sulfonamidas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bridged Bicyclo Compounds); 0 (Liver X Receptors); 0 (Propanols); 0 (Receptors, Retinoic Acid); 0 (Receptors, Steroid); 0 (Sulfonamides); 0 (pregnane X receptor); 0 (retinoic acid receptor gamma); 3D632GYQ50 (hexafluoroisopropanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  3 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28886578
[Au] Autor:Kim JH
[Ad] Endereço:Division of Pharmacology, School of Korean Medicine, Pusan National University,50612, Republic of Korea. Electronic address: kmsct@pusan.ac.kr.
[Ti] Título:Extraction time and temperature affect the extraction efficiencies of coumarin and phenylpropanoids from Cinnamomum cassia bark using a microwave-assisted extraction method.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:196-203, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Microwave-assisted extraction (MAE), an efficient extraction tool, was employed to extract a coumarin and five phenylpropanoids (cinnamic acid, cinnamyl alcohol, cinnamaldehyde, 2-hydroxycinnamadehyde, and 2-methoxycinnamaldehyde) from Cinnamomum cassia bark using water as the extraction solvent. Six marker compounds were quantified by high-performance liquid chromatography-diode array detector using a validated analytical method. To investigate the influences of temperature and time on the extraction yields of the six marker compounds, the water extracts of C. cassia bark were prepared using a MAE method at six different extraction temperatures (70, 75, 80, 85, 90, and 95°C) and times (2, 4, 6, 8, 10, and 12min). Their influences were assessed by multiple regression analysis. The results obtained demonstrated that higher extraction temperature and longer extraction time positively affected coumarin and cinnamyl alcohol contents, but negatively affected extract contents of cinnamic acid, cinnamaldehyde and 2-hydroxycinnamaldehyde (all p-<0.05). The extraction of 2-methoxycinnamaldehyde was affected by both positively and negatively by increasing temperature and time. These changes during MAE were assumed by the chemical natures of the marker compounds with various functional groups. In conclusion, temperature and times significantly affected the extraction efficiencies of a coumarin and five phenylpropanoids from C. cassia bark when a water-based MAE method was used. This study provides a novel approach to the preparation of the water extract of C. cassia bark using MAE.
[Mh] Termos MeSH primário: Fracionamento Químico/métodos
Cinamatos
Cinnamomum aromaticum/química
Cumarínicos/isolamento & purificação
Casca de Planta/química
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Cromatografia Líquida de Alta Pressão/métodos
Cinamatos/análise
Cinamatos/química
Cinamatos/isolamento & purificação
Cumarínicos/análise
Cumarínicos/química
Modelos Lineares
Micro-Ondas
Extratos Vegetais/química
Propanóis
Análise de Regressão
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Coumarins); 0 (Plant Extracts); 0 (Propanols); 7864XYD3JJ (Acrolein); A4VZ22K1WT (coumarin); SR60A3XG0F (cinnamic aldehyde); SS8YOP444F (cinnamyl alcohol); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


  4 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28787461
[Au] Autor:Kajla S; Mukhopadhyay A; Pradhan AK
[Ad] Endereço:Department of Genetics, University of Delhi South Campus, New Delhi, India.
[Ti] Título:Development of transgenic Brassica juncea lines for reduced seed sinapine content by perturbing phenylpropanoid pathway genes.
[So] Source:PLoS One;12(8):e0182747, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sinapine is a major anti-nutritive compound that accumulates in the seeds of Brassica species. When ingested, sinapine imparts gritty flavuor in meat and milk of animals and fishy odor to eggs of brown egg layers, thereby compromising the potential use of the valuable protein rich seed meal. Sinapine content in Brassica juncea germplasm ranges from 6.7 to 15.1 mg/g of dry seed weight (DSW) which is significantly higher than the prescribed permissible level of 3.0 mg/g of DSW. Due to limited natural genetic variability, conventional plant breeding approach for reducing the sinapine content has largely been unsuccessful. Hence, transgenic approach for gene silencing was adopted by targeting two genes-SGT and SCT, encoding enzymes UDP- glucose: sinapate glucosyltransferase and sinapoylglucose: choline sinapoyltransferase, respectively, involved in the final two steps of sinapine biosynthetic pathway. These two genes were isolated from B. juncea and eight silencing constructs were developed using three different RNA silencing approaches viz. antisense RNA, RNAi and artificial microRNA. Transgenics in B. juncea were developed following Agrobacterium-mediated transformation. From a total of 1232 independent T0 transgenic events obtained using eight silencing constructs, 25 homozygous lines showing single gene inheritance were identified in the T2 generation. Reduction of seed sinapine content in these lines ranged from 15.8% to 67.2%; the line with maximum reduction had sinapine content of 3.79 mg/g of DSW. The study also revealed that RNAi method was more efficient than the other two methods used in this study.
[Mh] Termos MeSH primário: Colina/análogos & derivados
Genes de Plantas/genética
Mostardeira/genética
Mostardeira/metabolismo
Propanóis/metabolismo
Sementes/metabolismo
[Mh] Termos MeSH secundário: Colina/metabolismo
Simulação por Computador
Regulação da Expressão Gênica de Plantas
Glucosiltransferases/química
Glucosiltransferases/genética
Glucosiltransferases/metabolismo
Homozigoto
Modelos Moleculares
Mostardeira/enzimologia
Plantas Geneticamente Modificadas
Regiões Promotoras Genéticas/genética
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Propanols); 09211A0HHL (sinapine); 0F897O3O4M (1-phenylpropanol); EC 2.4.1.- (Glucosyltransferases); N91BDP6H0X (Choline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182747


  5 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28737916
[Au] Autor:Choi SK; Mun GI; Choi E; Kim SY; Kwon Y; Na Y; Lee YS
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Ewha Womans University , Seoul 120-750, Korea.
[Ti] Título:The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection.
[So] Source:J Nat Prod;80(8):2379-2383, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Células da Medula Óssea/citologia
Proteínas de Ligação a DNA/metabolismo
Propano/análogos & derivados
Propanóis/farmacologia
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Acroleína/química
Acroleína/farmacologia
Animais
Células da Medula Óssea/química
Proteínas de Ligação a DNA/química
Fatores de Transcrição de Choque Térmico
Camundongos
Estrutura Molecular
Propano/química
Propano/farmacologia
Propanóis/química
Fatores de Transcrição/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-hydroxy-3-methoxyphenylpropanal); 0 (4-hydroxy-3-methoxyphenylpropanol); 0 (DNA-Binding Proteins); 0 (Heat Shock Transcription Factors); 0 (Propanols); 0 (Transcription Factors); 06TPT01AD5 (coniferaldehyde); 7864XYD3JJ (Acrolein); T75W9911L6 (Propane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00126


  6 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28606145
[Au] Autor:Liu S; Liu J; Hou J; Chao N; Gai Y; Jiang X
[Ad] Endereço:College of Biological Science and Technology, Beijing Forestry University, Beijing, 100083, People's Republic of China.
[Ti] Título:Three steps in one pot: biosynthesis of 4-hydroxycinnamyl alcohols using immobilized whole cells of two genetically engineered Escherichia coli strains.
[So] Source:Microb Cell Fact;16(1):104, 2017 Jun 12.
[Is] ISSN:1475-2859
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: 4-Hydroxycinnamyl alcohols are a class of natural plant secondary metabolites that include p-coumaryl alcohol, caffeyl alcohol, coniferyl alcohol and sinapyl alcohol, and have physiological, ecological and biomedical significance. While it is necessary to investigate the biological pathways and economic value of these alcohols, research is hindered because of their limited availability and high cost. Traditionally, these alcohols are obtained by chemical synthesis and plant extraction. However, synthesis by biotransformation with immobilized microorganisms is of great interest because it is environmentally friendly and offers high stability and regenerable cofactors. Therefore, we produced 4-hydroxycinnamyl alcohols using immobilized whole cells of engineered Escherichia coli as the biocatalyst. RESULTS: In this study, we used the recombinant E. coli strain, M15-4CL1-CCR, expressing the fusion protein 4-coumaric acid: coenzyme A ligase and the cinnamoyl coenzyme A reductase and a recombinant E. coli strain, M15-CAD, expressing cinnamyl alcohol dehydrogenase from Populus tomentosa (P. tomentosa). High performance liquid chromatography and mass spectrometry showed that the immobilized whole cells of the two recombinant E. coli strains could effectively convert the phenylpropanoic acids to their corresponding 4-hydroxycinnamyl alcohols. Further, the optimum buffer pH and the reaction temperature were pH 7.0 and 30 °C. Under these conditions, the molar yield of the p-coumaryl alcohol, the caffeyl alcohol and the coniferyl alcohol was around 58, 24 and 60%, respectively. Moreover, the highly sensitive and selective HPLC-PDA-ESI-MSn method used in this study could be applied to the identification and quantification of these aromatic polymers. CONCLUSIONS: We have developed a dual-cell immobilization system for the production of 4-hydroxycinnamyl alcohols from inexpensive phenylpropanoic acids. This biotransformation method is both simple and environmental-friendly, which is promising for the practical and cost effective synthesis of natural products. Graphical abstract Biotransformation process of phenylpropanoic acids by immobilized whole-cells.
[Mh] Termos MeSH primário: Oxirredutases do Álcool/metabolismo
Escherichia coli/genética
Escherichia coli/metabolismo
Engenharia Genética
Propanóis/metabolismo
[Mh] Termos MeSH secundário: Vias Biossintéticas
Células Imobilizadas/metabolismo
Escherichia coli/citologia
Propanóis/química
Proteínas Recombinantes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Propanols); 0 (Recombinant Proteins); EC 1.1.- (Alcohol Oxidoreductases); EC 1.1.1.195 (cinnamyl alcohol dehydrogenase); SS8YOP444F (cinnamyl alcohol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1186/s12934-017-0722-9


  7 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Alves, Ricardo J
Texto completo
[PMID]:28590516
[Au] Autor:Lavorato SN; Duarte MC; Lage DP; Tavares CAP; Coelho EAF; Alves RJ
[Ad] Endereço:Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
[Ti] Título:1,3-Bis(aryloxy)propan-2-ols as potential antileishmanial agents.
[So] Source:Chem Biol Drug Des;90(5):981-986, 2017 Nov.
[Is] ISSN:1747-0285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We describe herein the synthesis and antileishmanial activity of 1,3-bis(aryloxy)propan-2-ols. Five compounds (2, 3, 13, 17, and 18) exhibited an effective antileishmanial activity against stationary promastigote forms of Leishmania amazonensis (IC  < 15.0 µm), and an influence of compound lipophilicity on activity was suggested. Most of the compounds were poorly selective, as they showed toxicity toward murine macrophages, except 17 and 18, which presented good selective indexes (SI ≥ 10.0). The five more active compounds (2, 3, 13, 17, and 18) were selected for the treatment of infected macrophages, and all of them were able to reduce the number of internalized parasites by more than 80%, as well as the number of infected macrophages by more than 70% in at least one of the tested concentrations. Altogether, these results demonstrate the potential of these compounds as new hits of antileishmanial agents and open future possibilities for them to be tested in in vivo studies.
[Mh] Termos MeSH primário: Leishmania mexicana/efeitos dos fármacos
Leishmaniose Cutânea/tratamento farmacológico
Propanóis/química
Propanóis/uso terapêutico
Tripanossomicidas/química
Tripanossomicidas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Concentração Inibidora 50
Leishmaniose Cutânea/parasitologia
Macrófagos/parasitologia
Camundongos Endogâmicos BALB C
Propanóis/farmacologia
Tripanossomicidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Propanols); 0 (Trypanocidal Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1111/cbdd.13024


  8 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28554062
[Au] Autor:Hielscher J; Monien BH; Abraham K; Jessel S; Seidel A; Lampen A
[Ad] Endereço:German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
[Ti] Título:An isotope-dilution UPLC-MS/MS technique for the human biomonitoring of the internal exposure to glycidol via a valine adduct at the N-terminus of hemoglobin.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1059:7-13, 2017 Aug 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fatty acid esters of glycidol (glycidyl esters) are processing contaminants generated as a byproduct of the industrial deodorization of vegetable oils and fats. Oral intake of glycidyl esters leads to the release of glycidol in the gastrointestinal tract. Glycidol is carcinogenic, genotoxic and teratogenic in rodents. It is rated as probably carcinogenic to humans (IARC group 2A). The determination of internal exposure of glycidol may support the assessment of the possible human health risks related to glycidyl ester intake. For this purpose, hemoglobin adducts of glycidol may be suitable biomarkers reflecting the cumulative exposure of up to four months. We applied a modified Edman degradation to assess the glycidol adduct at the N-terminal valine, N-(2,3-dihydroxypropyl)-valine (2,3-diHOPr-Val), of hemoglobin. The modified valine was cleaved with fluorescein-5-isothiocyanate (FITC), resulting in the formation of N-(2,3-dihydroxypropyl)-valine fluorescein thiohydantoin (DHP-Val-FTH). An isotope-dilution technique was developed for the quantification of the thiohydantoin analyte by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and DHP-Val-d -FTH as reference standard. The limit of detection was 4 fmol DHP-Val-FTH per injection corresponding to 0.7pmol 2,3-diHOPr-Val/g hemoglobin. The adduct levels in blood samples of 12 non-smoking participants were in the range of 2.2-4.9pmol 2,3-diHOPr-Val/g hemoglobin. The current work presents the first isotope-dilution technique using UPLC-MS/MS for the quantification of 2,3-diHOPr-Val at the N-terminus of hemoglobin as a sensitive and convenient alternative to earlier GC-MS methods.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Compostos de Epóxi/análise
Ésteres/análise
Propanóis/análise
Espectrometria de Massas em Tandem/métodos
Valina/análise
[Mh] Termos MeSH secundário: Compostos de Epóxi/sangue
Ésteres/sangue
Fluoresceína-5-Isotiocianato/química
Cromatografia Gasosa-Espectrometria de Massas
Hemoglobinas/análise
Seres Humanos
Marcação por Isótopo/métodos
Isótopos
Limite de Detecção
Propanóis/sangue
Reprodutibilidade dos Testes
Valina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Epoxy Compounds); 0 (Esters); 0 (Hemoglobins); 0 (Isotopes); 0 (Propanols); HG18B9YRS7 (Valine); I223NX31W9 (Fluorescein-5-isothiocyanate); S54CF1DV9A (glycidol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


  9 / 2088 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28531323
[Au] Autor:Cha DH; Landolt PJ; Adams TB
[Ad] Endereço:USDA-ARS, US Pacific Basin Agricultural Research Center, 64 Nowelo St., Hilo, HA 96720.
[Ti] Título:Effect of Chemical Ratios of a Microbial-Based Feeding Attractant on Trap Catch of Drosophila suzukii (Diptera: Drosophilidae).
[So] Source:Environ Entomol;46(4):907-915, 2017 08 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Drosophila suzukii Matsumura, spotted wing drosophila, can be trapped with a feeding attractant based on wine and vinegar volatiles and consisting of acetic acid, ethanol, acetoin, and methionol. Using that four-component blend, we found that the catch of spotted wing drosophila increased with increases in the release rate of acetoin (from 0.5 mg/d to 34 mg/d) from polyethylene sachet dispensers, and with increases in the concentrations of acetic acid (from 0.25% to 4%) or ethanol (from 0.08% to 2%) when dispensed in the trap drowning solution. However, we saw no increase in spotted wing drosophila trapped with increase of the methionol release rate from 0.4 mg/d to 4.9 mg/d or from 0.19 mg/d to 0.8 mg/d, from sachets. A new formulation based on optimized amounts of these four chemicals yielded a doubling of spotted wing drosophila trapped compared to a previously reported formulation. Further field testing confirmed that the simultaneous increases in the release rate of acetoin from a dispenser and the amount of acetic acid in the trap drowning solution provided the increased spotted wing drosophila trap response to the new formulation. These findings provide a practical means to improve the power of this lure to detect and monitor D. suzukii.
[Mh] Termos MeSH primário: Quimiotaxia
Drosophila/efeitos dos fármacos
Controle de Insetos
Feromônios/farmacologia
[Mh] Termos MeSH secundário: Ácido Acético/farmacologia
Acetoína/farmacologia
Animais
Relação Dose-Resposta a Droga
Drosophila/fisiologia
Etanol/farmacologia
Feminino
Masculino
Propanóis/farmacologia
Sulfetos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pheromones); 0 (Propanols); 0 (Sulfides); 0 (insect attractants); 3K9958V90M (Ethanol); BG4D34CO2H (Acetoin); H1E1U441XX (methionol); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx079


  10 / 2088 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28515379
[Au] Autor:Koyama K; Miyazaki K; Abe K; Egawa Y; Fukazawa T; Kitta T; Miyashita T; Nezu T; Nohara H; Sano T; Takahashi Y; Taniguchi H; Yada H; Yamazaki K; Watanabe Y
[Ad] Endereço:Research & Development Headquaters, House Foods Group Inc.
[Ti] Título:Alternative Internal Standard Calibration of an Indirect Enzymatic Analytical Method for 2-MCPD Fatty Acid Esters.
[So] Source:J Oleo Sci;66(6):585-590, 2017 Jun 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:An indirect enzymatic analysis method for the quantification of fatty acid esters of 2-/3-monochloro-1,2-propanediol (2/3-MCPD) and glycidol was developed, using the deuterated internal standard of each free-form component. A statistical method for calibration and quantification of 2-MCPD-d , which is difficult to obtain, is substituted by 3-MCPD-d used for calculation of 3-MCPD. Using data from a previous collaborative study, the current method for the determination of 2-MCPD content using 2-MCPD-d was compared to three alternative new methods using 3-MCPD-d . The regression analysis showed that the alternative methods were unbiased compared to the current method. The relative standard deviation (RSD ) among the testing laboratories was ≤ 15% and the Horwitz ratio was ≤ 1.0, a satisfactory value.
[Mh] Termos MeSH primário: Calibragem/normas
Ensaios Enzimáticos/métodos
Compostos de Epóxi/análise
Ésteres/análise
Ácidos Graxos/análise
Análise de Alimentos/métodos
Glicerol/análogos & derivados
Propanóis/análise
[Mh] Termos MeSH secundário: Gorduras Insaturadas na Dieta/análise
Glicerol/análise
Análise de Regressão
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-monochloropropanediol); 0 (Dietary Fats, Unsaturated); 0 (Epoxy Compounds); 0 (Esters); 0 (Fatty Acids); 0 (Propanols); PDC6A3C0OX (Glycerol); S54CF1DV9A (glycidol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16229



página 1 de 209 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde