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[PMID]: 29337669 [Au] Autor: Kim JI; Park SW; Lim JJ; Sohn SI; Shin JS; Park SC; Jang YP; Chung EK; Lee HW; Lee KT [Ad] Endereço: 1Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul, 02447, Korea Republic of. [Ti] Título: Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury. [So] Source: Acta Pharm;67(4):479-494, 2017 Dec 20. [Is] ISSN: 1846-9558 [Cp] País de publicação: Croatia [La] Idioma: eng [Ab] Resumo: In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer. [Mh] Termos MeSH primário: Artemisia/química Mucosa Gástrica/efeitos dos fármacos Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: 2-Propanol Animais Antiulcerosos/farmacologia Cães Etanol/efeitos adversos Flavonoides/farmacologia Indometacina/efeitos adversos Ligadura/efeitos adversos Masculino Úlcera Péptica Hemorrágica/induzido quimicamente Úlcera Péptica Hemorrágica/etiologia Úlcera Péptica Hemorrágica/prevenção & controle Extratos Vegetais/administração & dosagem Ratos Ratos Sprague-Dawley Úlcera Gástrica/induzido quimicamente Úlcera Gástrica/complicações Úlcera Gástrica/prevenção & controle Comprimidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Ulcer Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (Tablets); 3K9958V90M (Ethanol); 4D58O05490 (eupatilin); ND2M416302 (2-Propanol); XXE1CET956 (Indomethacin) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180131 [Lr] Data última revisão: 180131 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180117 [St] Status: MEDLINE

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[PMID]: 28868763 [Au] Autor: Shinde S; Rode C [Ad] Endereço: Chemical Engineering and Process Development Division, CSIR National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India. [Ti] Título: Cascade Reductive Etherification of Bioderived Aldehydes over Zr-Based Catalysts. [So] Source: ChemSusChem;10(20):4090-4101, 2017 Oct 23. [Is] ISSN: 1864-564X [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: An efficient one-pot catalytic cascade sequence has been developed for the production of value-added ethers from bioderived aldehydes. Etherification of 5-(hydroxymethyl)furfural with different aliphatic alcohols over acidic Zr-montmorillonite (Zr-Mont) catalyst produced a mixture of 5-(alkoxymethyl)furfural and 2-(dialkoxymethyl)-5-(alkoxymethyl)furan. The latter was selectively converted back into 5-(alkoxymethyl)furfural by treating it with water over the same catalyst. The synthesis of 2,5-bis(alkoxymethyl)furan was achieved through a cascade sequence involving etherification, transfer hydrogenation, and re-etherification over a combination of acidic Zr-Mont and the charge-transfer hydrogenation catalyst [ZrO(OH) ]. This catalyst combination was further explored for the cascade conversion of 2-furfuraldehyde into 2-(alkoxymethyl)furan. The scope of this strategy was then extended for the reductive etherification of lignin-derived arylaldehydes to obtain the respective benzyl ethers in >80 % yield. Additionally, the mixture of Zr-Mont and ZrO(OH) does not undergo mutual destruction, which was proved by recycling experiments and XRD analysis. Both the catalysts were thoroughly characterized using BET, temperature-programmed desorption of NH and CO , pyridine-FTIR, XRD, inductively coupled plasma optical emission spectroscopy, and X-ray photoelectron spectroscopy techniques. [Mh] Termos MeSH primário: Aldeídos/química Éteres/química Zircônio/química [Mh] Termos MeSH secundário: 2-Propanol/química Catálise Furaldeído/análogos & derivados Furaldeído/química Hidrogenação Modelos Moleculares Conformação Molecular Oxirredução [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aldehydes); 0 (Ethers); 70ETD81LF0 (5-hydroxymethylfurfural); C6V6S92N3C (Zirconium); DJ1HGI319P (Furaldehyde); ND2M416302 (2-Propanol) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171106 [Lr] Data última revisão: 171106 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170905 [St] Status: MEDLINE [do] DOI: 10.1002/cssc.201701275

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[PMID]: 28772091 [Au] Autor: Linakis MW; Job KM; Liu X; Collingwood SC; Pangburn HA; Ott DK; Sherwin CMT [Ad] Endereço: a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah , Salt Lake City , UT , USA. [Ti] Título: Riding (High) into the danger zone: a review of potential differences in chemical exposures in fighter pilots resulting from high altitude and G-forces. [So] Source: Expert Opin Drug Metab Toxicol;13(9):925-934, 2017 Sep. [Is] ISSN: 1744-7607 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: INTRODUCTION: When in flight, pilots of high performance aircraft experience conditions unique to their profession. Training flights, performed as often as several times a week, can expose these pilots to altitudes in excess of 15 km (~50,000 ft, with a cabin pressurized to an altitude of ~20,000 ft), and the maneuvers performed in flight can exacerbate the G-forces felt by the pilot. While the pilots specifically train to withstand these extreme conditions, the physiologic stress could very likely lead to differences in the disposition of chemicals in the body, and consequently, dangerously high exposures. Unfortunately, very little is known about how the conditions experienced by fighter pilots affects chemical disposition. Areas covered: The purpose of this review is to present information about the effects of high altitude, G-forces, and other conditions experienced by fighter pilots on chemical disposition. Using this information, the expected changes in chemical exposure will be discussed, using isopropyl alcohol as an example. Expert opinion: There is a severe lack of information concerning the effects of the fighter pilot environment on the pharmacokinetics and pharmacodynamics of chemicals. Given the possibility of exposure prior to or during flight, it is important that these potential effects be investigated further. [Mh] Termos MeSH primário: Altitude Doenças Profissionais/fisiopatologia Pilotos [Mh] Termos MeSH secundário: 2-Propanol/envenenamento Aeronaves Animais Gravitação Seres Humanos Exposição Ocupacional/efeitos adversos Estresse Fisiológico/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: ND2M416302 (2-Propanol) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170922 [Lr] Data última revisão: 170922 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170804 [St] Status: MEDLINE [do] DOI: 10.1080/17425255.2017.1360867

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[PMID]: 28759748 [Au] Autor: Zhao Z; Xing X; Ou X; Liu X; Zhou R; Zhang H; Yang L; Zhuang Z; Su X; Lu Y; Jiang J; Yang Y; Cui D; He Y [Ad] Endereço: Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China. [Ti] Título: DNA damage levels in electronics workers in Southern China: A micro-whole blood comet assay. [So] Source: Mutat Res;803-805:17-21, 2017 Oct. [Is] ISSN: 1873-135X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: We evaluated DNA damage levels of different categories of workers exposed to hazards inside electronics factories in Southern China. To find out the most dangerous risk factor, a cross-sectional study was conducted on a total of 584 exposed subjects and 138 controls in an electronics factory in Southern China, where the electronics industry is prevalent. The exposed hazards included isopropanol (IPO), lead, noise, video display terminals (VDT), lead in a high-temperature (high-temp) environment, and IPO in a high-temp environment. DNA damage detection was performed by the micro-whole blood comet assay using peripheral blood. DNA damage levels were estimated by percent tail DNA (%T). Linear regression models were used to test DNA damage differences between exposed groups and control group with adjustments for potential confounding factors. The level of DNA damage was more significant in both lead in a high-temp and IPO in a high-temp environment groups than in that of the controls (p<0.05). The differences remained significant after stratifying by smoking status (p<0.05). There were no significant differences between groups exposed to IPO, lead, noise, VDT environment and controls. In conclusion, we identified potential risk factors for DNA damage to electronics workers. Special attention should be paid to workers exposed to IPO and lead in a high-temp environment. [Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos Substâncias Perigosas/toxicidade Indústria Manufatureira Exposição Ocupacional/efeitos adversos [Mh] Termos MeSH secundário: 2-Propanol/toxicidade Acetona/toxicidade Adolescente Adulto Benzeno/toxicidade China Ensaio Cometa Estudos Transversais Feminino Temperatura Alta Seres Humanos Chumbo/toxicidade Modelos Lineares Masculino Inquéritos e Questionários Tolueno/toxicidade Xilenos/toxicidade Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hazardous Substances); 0 (Xylenes); 1364PS73AF (Acetone); 2P299V784P (Lead); 3FPU23BG52 (Toluene); J64922108F (Benzene); ND2M416302 (2-Propanol) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171011 [Lr] Data última revisão: 171011 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170801 [St] Status: MEDLINE

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[PMID]: 28755490 [Au] Autor: Okahashi N; Matsuda F; Yoshikawa K; Shirai T; Matsumoto Y; Wada M; Shimizu H [Ad] Endereço: Department of Bioinfomatic Engineering, Graduate School of Information Science and Technology, Osaka University, Osaka, Japan. [Ti] Título: Metabolic engineering of isopropyl alcohol-producing Escherichia coli strains with C-metabolic flux analysis. [So] Source: Biotechnol Bioeng;114(12):2782-2793, 2017 Dec. [Is] ISSN: 1097-0290 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Metabolic engineering of isopropyl alcohol (IPA)-producing Escherichia coli strains was conducted along with C-metabolic flux analysis (MFA). A metabolically engineered E. coli strain expressing the adc gene derived from Clostridium acetobutylicum and the IPADH gene from C. beijerinckii did not produce IPA during its exponential growth phase in the aerobic batch culture. C-MFA was carried out, and revealed a deficiency in NADPH regeneration for IPA production in growth phase. Based on these findings, we used nitrogen-starved culture conditions to reduce NADPH consumption for biomass synthesis. As a result, IPA yield was increased to 20% mol/mol glucose. C-MFA revealed that the relative flux levels through the oxidative pentose phosphate (PP) pathway and the TCA cycle were elevated in nitrogen-starved condition relative to glucose uptake rate. To prevent CO release in the 6-phosphogluconate dehydrogenase (6PGDH) reaction, metabolism of this E. coli strain was further engineered to redirect glycolytic flux to the glucose 6-phosphate dehydrogenase (G6PDH) and Entner-Doudoroff (ED) pathway. IPA yield of 55% mol/mol glucose was achieved by combining the nitrogen-starved culture condition with the metabolic redirection. The C-MFA data and intracellular NADPH levels obtained under these IPA production conditions revealed linear correlations between the specific IPA production rate and NADPH concentration, as well as between IPA yield and the pyruvate dehydrogenase (PDH) flux. Our results showed that C-MFA is a helpful tool for metabolic engineering studies, and that further improvement in IPA production by E. coli may be achieved by fine-tuning the cofactor ratio and concentrations, as well as optimizing the metabolic pathways and culture conditions. [Mh] Termos MeSH primário: 2-Propanol/metabolismo Proteínas de Bactérias/metabolismo Escherichia coli/metabolismo Engenharia Metabólica/métodos Análise do Fluxo Metabólico/métodos Redes e Vias Metabólicas/fisiologia [Mh] Termos MeSH secundário: 2-Propanol/isolamento & purificação Proteínas de Bactérias/genética Isótopos de Carbono/farmacocinética Escherichia coli/classificação Escherichia coli/citologia Melhoramento Genético/métodos Especificidade da Espécie [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Bacterial Proteins); 0 (Carbon Isotopes); ND2M416302 (2-Propanol) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170730 [St] Status: MEDLINE [do] DOI: 10.1002/bit.26390

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[PMID]: 28739275 [Au] Autor: Dorival-García N; Bones J [Ad] Endereço: Characterisation and Comparability Laboratory, NIBRT-The National Institute for Bioprocessing Research and Training, Foster Avenue, Mount Merrion, Blackrock, Co., Dublin, Ireland. [Ti] Título: Evaluation of solvent systems for optimized extractables studies of single use bioprocessing solutions. [So] Source: J Chromatogr A;1513:69-77, 2017 Sep 01. [Is] ISSN: 1873-3778 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Despite their advantages, there is concern that single-use systems used in biopharmaceutical manufacture might release potentially toxic substances during standard unit operations that negatively impact cell growth. Characterization of the extractables profile for single-use systems is necessary to know which compounds potentially become leachables under operational cell culture conditions. A key issue in the design of extractables studies is the composition of the model solvent, in particular its pH and polarity. In this study, a new approach, based on design of experiments (DoE), has been applied to determine the composition of the model solvent for extractable profiling of single-use bags (SUBs). Particular focus was placed on the determination of the degradation products of the antioxidant Irgafos 168 , due to evidence that some of these degradation products have cytotoxic effects on CHO cells. Results indicated that 2-propanol:water is the most appropriate solvent for the extraction of highly hydrophobic compounds with polar groups and/or acid-base properties from SUBs. The described DoE approach simplifies the number of experiments, evaluates all possible solvent water mixtures to select the best extraction solvent based on polarity, establishes the influence of each variable and provides information about variable interaction, which represents an important improvement over current best practice. The developed approach was applied to seven SUBs from different vendors and production dates facilitating the identification of potentially non-satisfactory films for cultivation of CHO cell lines under process conditions. [Mh] Termos MeSH primário: Técnicas de Cultura de Células/métodos Extração em Fase Sólida/métodos Solventes/química [Mh] Termos MeSH secundário: 2-Propanol/química Animais Antioxidantes/análise Antioxidantes/química Células CHO/química Células CHO/metabolismo Calibragem Cromatografia Líquida de Alta Pressão Cricetulus Interações Hidrofóbicas e Hidrofílicas Espectrometria de Massas Fosfitos/química Água/química [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Phosphites); 0 (Solvents); 059QF0KO0R (Water); 31570-04-4 (tris-(2,4-di-tert-butylphenyl) phosphite); ND2M416302 (2-Propanol) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170825 [Lr] Data última revisão: 170825 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170726 [St] Status: MEDLINE

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[PMID]: 28711498 [Au] Autor: Park BM; Bak SS; Shin KO; Kim M; Kim D; Jung SH; Jeong S; Sung YK; Kim HJ [Ad] Endereço: CRID Center, NeoPharm Co., Ltd., Daejeon, Republic of Korea; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea. [Ti] Título: Promotion of hair growth by newly synthesized ceramide mimetic compound. [So] Source: Biochem Biophys Res Commun;491(1):173-177, 2017 Sep 09. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Based on the crucial roles of ceramides in skin barrier function, use of ceramides or their structural mimetic compounds, pseudoceramides, as cosmetic ingredients are getting more popular. While currently used pseudoceramides are intended to substitute the structural roles of ceramides in stratum corneum, development of bioactive pseudoceramides has been repeatedly reported. In this study, based on the potential involvement of sphingolipids in hair cycle regulation, we investigated the effects of newly synthesized pseudoceramide, bis-oleamido isopropyl alcohol (BOI), on hair growth using cultured human hair follicles and animal models. BOI treatment promoted hair growth in cultured human hair follicles ex vivo and induced earlier conversion of telogen into anagen. Although we did not find a significant enhancement of growth factor expression and follicular cell proliferation, BOI treatment resulted in an increased sphinganine and sphingosine contents as well as increased ceramides contents in cultured dermal papilla (DP) cells. Taken together, our data strongly suggest that biologically active pseudoceramide promotes hair growth by stimulating do novo synthesis of sphingolipids in DP cells. [Mh] Termos MeSH primário: Materiais Biomiméticos/farmacologia Ceramidas/farmacologia Preparações para Cabelo/farmacologia Cabelo/efeitos dos fármacos Cabelo/crescimento & desenvolvimento [Mh] Termos MeSH secundário: 2-Propanol Materiais Biomiméticos/síntese química Células Cultivadas Ceramidas/administração & dosagem Fármacos Dermatológicos/síntese química Fármacos Dermatológicos/farmacologia Relação Dose-Resposta a Droga Cabelo/citologia Preparações para Cabelo/síntese química Seres Humanos Masculino [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ceramides); 0 (Dermatologic Agents); 0 (Hair Preparations); ND2M416302 (2-Propanol) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170822 [Lr] Data última revisão: 170822 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170717 [St] Status: MEDLINE

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[PMID]: 28514947 [Au] Autor: Casey AL; Karpanen TJ; Conway BR; Worthington T; Nightingale P; Waters R; Elliott TSJ [Ad] Endereço: Department of Clinical Microbiology, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, B15 2WB, Birmingham, UK. [Ti] Título: Enhanced chlorhexidine skin penetration with 1,8-cineole. [So] Source: BMC Infect Dis;17(1):350, 2017 May 17. [Is] ISSN: 1471-2334 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Chlorhexidine (CHG) penetrates poorly into skin. The purpose of this study was to compare the depth of CHG skin permeation from solutions containing either 2% (w/v) CHG and 70% (v/v) isopropyl alcohol (IPA) or 2% (w/v) CHG, 70% (v/v) IPA and 2% (v/v) 1,8-cineole. METHODS: An ex-vivo study using Franz diffusion cells was carried out. Full thickness human skin was mounted onto the cells and a CHG solution, with or without 2% (v/v) 1,8-cineole was applied to the skin surface. After twenty-four hours the skin was sectioned horizontally in 100 µm slices to a depth of 2000 µm and the concentration of CHG in each section quantified using high performance liquid chromatography (HPLC). The data were analysed with repeated measures analysis of variance. RESULTS: The concentration of CHG in the skin on average was significantly higher (33.3% [95%, CI 1.5% - 74.9%]) when a CHG solution which contained 1,8-cineole was applied to the skin compared to a CHG solution which did not contain this terpene (P = 0.042). CONCLUSIONS: Enhanced delivery of CHG can be achieved in the presence of 1,8-cineole, which is the major component of eucalyptus oil. This may reduce the numbers of microorganisms located in the deeper layers of the skin which potentially could decrease the risk of surgical site infection. [Mh] Termos MeSH primário: Clorexidina/farmacocinética Cicloexanóis/farmacocinética Monoterpenos/farmacocinética Absorção Cutânea/efeitos dos fármacos [Mh] Termos MeSH secundário: 2-Propanol/administração & dosagem 2-Propanol/química Anti-Infecciosos Locais/administração & dosagem Anti-Infecciosos Locais/farmacocinética Clorexidina/administração & dosagem Clorexidina/química Cicloexanóis/administração & dosagem Cicloexanóis/química Feminino Seres Humanos Meia-Idade Monoterpenos/administração & dosagem Monoterpenos/química Soluções/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents, Local); 0 (Cyclohexanols); 0 (Monoterpenes); 0 (Solutions); ND2M416302 (2-Propanol); R4KO0DY52L (Chlorhexidine); RV6J6604TK (eucalyptol) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170818 [Lr] Data última revisão: 170818 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170519 [St] Status: MEDLINE [do] DOI: 10.1186/s12879-017-2451-4

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[PMID]: 28431688 [Au] Autor: Asfaw AA; Wolfs K; Schepdael AV; Adams E [Ad] Endereço: KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, Herestraat 49, O&N2, PB 923, 3000 Leuven, Belgium. [Ti] Título: Thermal desorption-Gas chromatographic methodology for the determination of residual solvents in mesoporous silica. [So] Source: J Chromatogr A;1500:160-166, 2017 Jun 02. [Is] ISSN: 1873-3778 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: In this work, thermal desorption-gas chromatography-flame ionization detection (TD-GC-FID) was adapted to enable the determination of residual solvents (RS) in mesoporous silica (MPSi). MPSi is often utilized in various pharmaceutical formulations or drug delivery systems and the accurate determination of RS is an important part of pharmaceutical quality control. Seven commonly used solvents (methanol, ethanol, acetone, isopropanol, dichloromethane, tetrahydrofuran and hexafluoroisopropanol) were evaluated in combination with 3 types of MPSi having pore sizes of 2-3, 15 and 25nm. Validation results showed general recovery values >98% and good linearity over the concentration ranges studied. The limits of detection (LOD) and limits of quantification (LOQ) for the different solvents ranged from 0.03 to 0.08µg and from 0.1 to 0.2µg per tube, respectively. Verification of the accuracy of the TD method was investigated by using an alternative method based on complete dissolution of MPSi in hydrofluoric acid (HF) followed by full evaporation headspace-GC (HS-GC). The results obtained from both procedures were not statistically different (p>0.05) when applied to actual experimental drug samples consisting of itraconazole loaded on MPSi. [Mh] Termos MeSH primário: Cromatografia Gasosa/métodos Dióxido de Silício/química Solventes/análise [Mh] Termos MeSH secundário: 2-Propanol/análise Acetona/análise Química Farmacêutica Etanol/análise Ionização de Chama Limite de Detecção Cloreto de Metileno/análise Controle de Qualidade [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Solvents); 1364PS73AF (Acetone); 3K9958V90M (Ethanol); 588X2YUY0A (Methylene Chloride); 7631-86-9 (Silicon Dioxide); ND2M416302 (2-Propanol) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170423 [St] Status: MEDLINE

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[PMID]: 28366568 [Au] Autor: Ragab MA; El-Kimary EI [Ad] Endereço: Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El-Messalah, Alexandria 21521, Egypt. Electronic address: marmed_2001@yahoo.com. [Ti] Título: High performance liquid chromatography with photo diode array for separation and analysis of naproxen and esomeprazole in presence of their chiral impurities: Enantiomeric purity determination in tablets. [So] Source: J Chromatogr A;1497:110-117, 2017 May 12. [Is] ISSN: 1873-3778 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: A stereoselective high performance liquid chromatographic method with diode array detection (HPLC-DAD) was introduced for S-naproxen and esomeprazole determination in tablets. The separation was achieved on a Kromasil Cellucoat chiral column using a mobile phase consisting of hexane: isopropanol: trifluoroacetic acid (TFA) (90:9.9:0.1 v/v/v). The proposed system was found to be suitable for the enantioseparation of naproxen and omeprazole biologically active isomers. After optimization of the chromatographic conditions, resolution values of 3.84 and 2.17 could be obtained for naproxen and omeprazole isomers, respectively. The method was fully validated for the determination of S-isomers of each drug in their dosage form. Also, the enentiomeric purity was determined in commercial tablet containing S-naproxen and esomeprazole. The enantiomeric purity was calculated for each drug and the chiral impurities (R-isomers) could be determined at 1% level. The method was validated and good results with respect to linearity, precision, accuracy, selectivity and robustness were obtained. The limits of detection (LOD) and quantification (LOQ) were 2.00, 6.50 and 0.10, 0.35µgmL for S-naproxen and esomeprazole, respectively. [Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão Esomeprazol/análise Naproxeno/análise Comprimidos/química [Mh] Termos MeSH secundário: 2-Propanol/química Hexanos/química Limite de Detecção Omeprazol/análise Reprodutibilidade dos Testes Estereoisomerismo Ácido Trifluoracético/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hexanes); 0 (Tablets); 57Y76R9ATQ (Naproxen); E5R8Z4G708 (Trifluoroacetic Acid); KG60484QX9 (Omeprazole); N3PA6559FT (Esomeprazole); ND2M416302 (2-Propanol) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170516 [Lr] Data última revisão: 170516 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170404 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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