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[PMID]:28763984
[Au] Autor:Banipal PK; Sharma M; Banipal TS
[Ad] Endereço:Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: pkbanipal@yahoo.com.
[Ti] Título:Solvation behavior and sweetness response of carbohydrates, their derivatives and sugar alcohols in thiamine HCl (vitamin B1) and pyridoxine HCl (vitamin B6) at different temperatures.
[So] Source:Food Chem;237:181-190, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Volumetric properties are important tools to study the solvation behavior of solutes and reveal valuable information about solute-solute/cosolute interactions. Therefore, standard partial molar volumes at infinite dilution have been calculated from density measurements for monosaccharides, their methoxy and deoxy derivatives, disaccharides and sugar alcohols in (0.05, 0.15, 0.25 and 0.35)molkg thiamine HCl and pyridoxine HCl solutions over temperature range (288.15-318.15)K at pressure, p=0.1MPa. The corresponding transfer volumes, expansibilities and apparent massic volumes have been evaluated to examine the solvation behavior and the basic taste quality of studied solutes. UV-Vis absorption study of these solutes has also been carried out in 1.0×10 molkg thiamine HCl and pyridoxine HCl solutions. Results have been compared with our previously reported studies carried out in l-ascorbic acid (vitamin C). Stereochemical effects on hydration controlled by dominant conformations of studied solutes have also been discussed.
[Mh] Termos MeSH primário: Carboidratos/química
[Mh] Termos MeSH secundário: Piridoxina
Solubilidade
Álcoois Açúcares
Temperatura Ambiente
Tiamina
Vitamina B 6
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Sugar Alcohols); 8059-24-3 (Vitamin B 6); KV2JZ1BI6Z (Pyridoxine); X66NSO3N35 (Thiamine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28699201
[Au] Autor:Guffa B; Nedic NM; Dabic Zagorac DC; Tosti TB; Gasic UM; Natic MM; Fotiric Aksic MM
[Ad] Endereço:Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080, Zemun, Serbia.
[Ti] Título:Characterization of Sugar and Polyphenolic Diversity in Floral Nectar of Different 'Oblacinska' Sour Cherry Clones.
[So] Source:Chem Biodivers;14(9), 2017 Sep.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:'Oblacinska' sour cherry, an autochthonous cultivar, is the most planted cultivar in Serbian orchards. Since fruit trees in temperate zone reward insects by producing nectar which 'quality' affects the efficiency of insect pollination, the aim of this study was analyzing of sugars and polyphenolics in floral nectar of 16 'Oblacinska' sour cherry clones with different yielding potential. The contents of sugars and sugar alcohols were analyzed by ion chromatography, while polyphenolic profile was established using liquid chromatography/mass spectrometry technique. Fourteen sugars and six sugar alcohols were detected in nectar samples and the most abundant were fructose, glucose, and sucrose. Eleven polyphenols were quantified using available standards, while another 17 were identified according to their exact masses and characteristic fragmentations. Among quantified polyphenols, rutin, naringenin, and chrysin were the most abundant in nectar. Principal component analysis showed that some polyphenol components (naringin, naringenin, and rutin) together with sugars had high impact of spatial distribution of nectar samples on score plot.
[Mh] Termos MeSH primário: Carboidratos/análise
Flores/química
Néctar de Plantas/química
Polifenóis/análise
Prunus avium/química
[Mh] Termos MeSH secundário: Flavanonas/análise
Glucose/análise
Sacarose/análise
Álcoois Açúcares/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Flavanones); 0 (Plant Nectar); 0 (Polyphenols); 0 (Sugar Alcohols); 57-50-1 (Sucrose); IY9XDZ35W2 (Glucose); N7TD9J649B (naringin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700061


  3 / 2180 MEDLINE  
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[PMID]:28601009
[Au] Autor:Chiara Pietrogrande M; Barbaro E; Bove MC; Clauser G; Colombi C; Corbella L; Cuccia E; Dalla Torre S; Decesari S; Fermo P; Gambaro A; Gianelle V; Ielpo P; Larcher R; Lazzeri P; Massabò D; Melchionna G; Nardin T; Paglione M; Perrino C; Prati P; Visentin M; Zanca N; Zangrando R
[Ad] Endereço:Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy. Electronic address: mpc@unife.it.
[Ti] Título:Results of an interlaboratory comparison of analytical methods for quantification of anhydrosugars and biosugars in atmospheric aerosol.
[So] Source:Chemosphere;184:269-277, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An interlaboratory comparison was performed to evaluate the analytical methods for quantification of anhydrosugars - levoglucosan, mannosan, galactosan - and biosugars - arabitol, glucose and mannitol - in atmospheric aerosol. The performance of 10 laboratories in Italy currently involved in such analyses was investigated on twenty-six PM (particulate matter) ambient filters, three synthetic PM filters and three aqueous standard solutions. An acceptable interlaboratory variability was found, determined as the mean relative standard deviation (RSD%) of the results from the participating laboratories, with the mean RSD% values ranging from 25% to 46% and decreasing with increasing sugar concentration. The investigated methods show good accuracy, evaluated as the percentage error (ε%) related to mean values, since method biases ranged within ±20% for most of the analytes measured in the different laboratories. The detailed investigation (ANOVA analysis at p < 0.05) of the contribution of each laboratory to the total variability and the measurement accuracy shows that comparable results are generated by the different methods, despite the great diversity in terms of extraction conditions, chromatographic separation - more recent LC (liquid chromatography) and EC (exchange chromatography) methods compared to more widespread GC (gas chromatography) - and detection systems, namely PAD (pulsed amperometric detection) or mass spectrometry.
[Mh] Termos MeSH primário: Aerossóis/análise
Poluentes Atmosféricos/análise
Carboidratos/análise
Monitoramento Ambiental/métodos
Espectrometria de Massas/métodos
Variações Dependentes do Observador
[Mh] Termos MeSH secundário: Cromatografia Líquida
Galactose/análogos & derivados
Galactose/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Glucose/análogos & derivados
Glucose/análise
Itália
Manose/análogos & derivados
Manose/análise
Material Particulado/análise
Álcoois Açúcares/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Air Pollutants); 0 (Carbohydrates); 0 (Particulate Matter); 0 (Sugar Alcohols); 0 (galactosan); 0 (mannosan); 5132N17FSD (1,6-anhydro-beta-glucopyranose); IY9XDZ35W2 (Glucose); PHA4727WTP (Mannose); X2RN3Q8DNE (Galactose); YFV05Y57M9 (arabitol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE


  4 / 2180 MEDLINE  
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[PMID]:28482325
[Au] Autor:Cho YU; Lee D; Lee JE; Kim KH; Lee DY; Jung YC
[Ad] Endereço:The Department of Bio and Fermentation Convergence Technology, BK21 PLUS Program, Kookmin University, Seoul 02707, Republic of Korea.
[Ti] Título:Exploratory metabolomics of biomarker identification for the internet gaming disorder in young Korean males.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1057:24-31, 2017 Jul 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The main aim of the current research is to characterize the molecular dynamics related to internet gaming disorder (IGD) using non-targeted plasma metabolite profiling based on gas-chromatography time-of-flight mass spectrometry (GC-TOF MS). IGD is a psychiatric disorder instigated by excessive and prolonged internet gaming, which shared many pathological symptoms with attention deficit hyperactivity disorder (ADHD). The prevalence of the disorder has been rapidly increased particularly in East Asia countries (5.9% in South Korea) compared to Europe or North America (0.3-1.0% in United States and 1.16% in Germany). Thus we comparably explored the correlation between plasma metabolites and internet addiction severity in IGD patients, and potential biomarker composite in combination with clinical parameters. The systematic metabolite profiling of 54 blood samples (normal user, N=28 and IGD, N=24) identified a total of 104 metabolites out of 1212 metabolic feature, and revealed unique relation of co-linearly regressed set of plasma metabolites (arabitol, myo-inositol, methionine, pyrrole-2-carboxylic acid, and aspartic acid) with internet addiction severity scale (R=0.795). In addition, orthogonal partial least squared discriminant analysis (OPLS-DA) and receiver operating characteristic (ROC) analysis identified the potential biomarker cluster that simultaneously discriminated the different types of the psychiatric status. The potential biomarker re-composite was comprehensively evaluated by a receiver operating characteristic (ROC) analysis where the AUCs were 0.890, 0.880, 1.000, and 0.935 for control, IGD, AD and IGD+AD, respectively (N=18, 19, 5, and 10) against the others. This exploratory method may provide robustness of predictive diagnosis in population screening of IGD. The identified metabolic features, the relatedness with clinical parameters, and the putative biochemical linkage will hopefully aid future pathological studies in IGD.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Internet
Transtornos Mentais/sangue
Metabolômica/métodos
Jogos de Vídeo
[Mh] Termos MeSH secundário: Ácido Aspártico/análise
Ácido Aspártico/sangue
Comportamento Aditivo
Análise Química do Sangue
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Inositol/sangue
Masculino
Metionina/sangue
Prolina/análogos & derivados
Prolina/sangue
Curva ROC
República da Coreia
Álcoois Açúcares/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Sugar Alcohols); 30KYC7MIAI (Aspartic Acid); 4L6452S749 (Inositol); 634-97-9 (2-pyrrolecarboxylic acid); 9DLQ4CIU6V (Proline); AE28F7PNPL (Methionine); YFV05Y57M9 (arabitol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE


  5 / 2180 MEDLINE  
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[PMID]:28319767
[Au] Autor:Dirbeba MJ; Brink A; DeMartini N; Zevenhoven M; Hupa M
[Ad] Endereço:Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Piispankatu 8, 20500 Turku, Finland. Electronic address: mdirbeba@abo.fi.
[Ti] Título:Potential for thermochemical conversion of biomass residues from the integrated sugar-ethanol process - Fate of ash and ash-forming elements.
[So] Source:Bioresour Technol;234:188-197, 2017 Jun.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this work, potential for thermochemical conversion of biomass residues from an integrated sugar-ethanol process and the fate of ash and ash-forming elements in the process are presented. Ash, ash-forming elements, and energy flows in the process were determined using mass balances and analyses of eight different biomass samples for ash contents, elemental compositions, and heating values. The results show that the ash content increases from the sugarcane to the final residue, vinasse. The cane straw, which is left in the field, contains one-third of the energy and 25% of the K and Cl while the vinasse contains 2% of the energy and 40% of the K and Cl in the cane. K and Cl in biomass fuels cause corrosion and fouling problems in boilers and gasifiers. Over 85% of these elements in the straw are water soluble indicating that water leaching would improve it for utilization in thermochemical conversion.
[Mh] Termos MeSH primário: Biomassa
[Mh] Termos MeSH secundário: Etanol
Saccharum
Álcoois Açúcares
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sugar Alcohols); 059QF0KO0R (Water); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


  6 / 2180 MEDLINE  
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[PMID]:28276771
[Au] Autor:Xu XM; Li DY; Hua HM; Li ZL; Liu Q
[Ad] Endereço:a Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
[Ti] Título:Two new threitol orsellinates from a sea mud-derived fungus, Ascotricha sp. ZJ-M-5.
[So] Source:J Asian Nat Prod Res;19(7):673-677, 2017 Jul.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new d-threitol orsellinates (1-2) were isolated from the EtOAc extract of a sea mud-derived fungus, Ascotricha sp. ZJ-M-5, cultured in Czapek Dox broth. These two compounds featured in the symmetrical substitution of orsellinic acid or acetic acid, which was established on the basis of 1D and 2D NMR experiments. The characteristic optical rotations enabled the assignment of the absolute configuration.
[Mh] Termos MeSH primário: Resorcinóis/isolamento & purificação
Álcoois Açúcares/isolamento & purificação
Xylariales/química
[Mh] Termos MeSH secundário: Ácido Acético/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Resorcinóis/química
Álcoois Açúcares/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 ((2R,3R)-1,2,3,4-butanetetraol-1,4-diorsellinate); 0 ((2R,3R)-14-diacetyl-1,2,3,4-butanetetraol-2,3-diorsellinate); 0 (Resorcinols); 0 (Sugar Alcohols); 11XLA0494B (orsellinic acid); 6DN82XBT5M (threitol); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1228635


  7 / 2180 MEDLINE  
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[PMID]:28190593
[Au] Autor:Hetrick EM; Kramer TT; Risley DS
[Ad] Endereço:Small Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, USA. Electronic address: hetrickem@lilly.com.
[Ti] Título:Evaluation of a hydrophilic interaction liquid chromatography design space for sugars and sugar alcohols.
[So] Source:J Chromatogr A;1489:65-74, 2017 Mar 17.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Based on a column-screening exercise, a column ranking system was developed for sample mixtures containing any combination of 26 sugar and sugar alcohol analytes using 16 polar stationary phases in the HILIC mode with acetonitrile/water or acetone/water mobile phases. Each analyte was evaluated on the HILIC columns with gradient elution and the subsequent chromatography data was compiled into a statistical software package where any subset of the analytes can be selected and the columns are then ranked by the greatest separation. Since these analytes lack chromophores, aerosol-based detectors, including an evaporative light scattering detector (ELSD) and a charged aerosol detector (CAD) were employed for qualitative and quantitative detection. Example qualitative applications are provided to illustrate the practicality and efficiency of this HILIC column ranking. Furthermore, the design-space approach was used as a starting point for a quantitative method for the trace analysis of glucose in trehalose samples in a complex matrix. Knowledge gained from evaluating the design-space led to rapid development of a capable method as demonstrated through validation of the following parameters: specificity, accuracy, precision, linearity, limit of quantitation, limit of detection, and range.
[Mh] Termos MeSH primário: Carboidratos/análise
Cromatografia Líquida de Alta Pressão/métodos
Álcoois Açúcares/análise
[Mh] Termos MeSH secundário: Algoritmos
Carboidratos/isolamento & purificação
Interações Hidrofóbicas e Hidrofílicas
Solventes/química
Álcoois Açúcares/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Solvents); 0 (Sugar Alcohols)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE


  8 / 2180 MEDLINE  
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[PMID]:28024614
[Au] Autor:Ghanavati R; Taheri A; Homayouni A
[Ad] Endereço:Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: royaghanavaty@yahoo.com.
[Ti] Título:Anomalous dissolution behavior of celecoxib in PVP/Isomalt solid dispersions prepared using spray drier.
[So] Source:Mater Sci Eng C Mater Biol Appl;72:501-511, 2017 Mar 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Celecoxib is a COX II inhibitor NSAID which is used for joint pains, rheumatoid arthritis and osteoarthritis, however due to its poor water solubility it shows very low oral bioavailability. Using solid dispersion formulations is one of the most promising strategies to increase solubility of poorly water soluble drugs. The purpose of this study is dissolution enhancement of celecoxib by preparation of solid dispersions via spray drying technique using PVP and Isomalt as hydrophilic carriers. Different ratios of celecoxib, Isomalt and PVP K30 (7:3:0, 5:5:0, 3:7:0, 1:9:0 and 3:5:2, 3:2:5) were prepared from 2% hydroalcoholic solutions (70:30 ethanol:water) using spray drier. Particle size analyzing, saturation solubility, SEM, DSC, FT-IR, XRPD and dissolution studies in 0.25% SDS and 0.04M Na HPO mediums were performed. Stability of samples was also studied after a week and a month storage at 75% humidity condition. The results showed that the saturation solubility of celecoxib in solid dispersion samples is 20-30 folds higher than raw celecoxib. Similar results have been shown for dissolution studies. Solid state analyses showed glass solution state of celecoxib in PVP/Isomalt matrixes. FTIR studies exhibited the formation of hydrogen bonding between celecoxib and PVP in these samples. Spray dried celecoxib (amorphous celecoxib) without usage of carrier showed lower dissolution rate compare to its crystalline state (in 0.25% SDS dissolution medium) whilst these results is vise versa in Na PO dissolution medium. Interestingly almost all samples exhibited higher dissolution rate (in 0.25% SDS) after storage in 75% humidity. XRPD analysis demonstrated the crystallization of amorphous celecoxib after 1month storage. In general using PVP K30 and Isomalt as hydrophilic carriers could increase solubility and dissolution rate of celecoxib in solid dispersion formulations.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/química
Celecoxib/química
Dissacarídeos/química
Portadores de Fármacos/química
Povidona/análogos & derivados
Álcoois Açúcares/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios não Esteroides/metabolismo
Varredura Diferencial de Calorimetria
Celecoxib/metabolismo
Cristalização
Composição de Medicamentos
Estabilidade de Medicamentos
Interações Hidrofóbicas e Hidrofílicas
Microscopia Eletrônica de Varredura
Tamanho da Partícula
Povidona/química
Solubilidade
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Disaccharides); 0 (Drug Carriers); 0 (Sugar Alcohols); 25249-54-1 (polyvinylpolypyrrolidone); 64519-82-0 (Palatinit); FZ989GH94E (Povidone); JCX84Q7J1L (Celecoxib)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE


  9 / 2180 MEDLINE  
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[PMID]:27955866
[Au] Autor:Zhang H; Han X; Wei C; Bao J
[Ad] Endereço:State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
[Ti] Título:Oxidative production of xylonic acid using xylose in distillation stillage of cellulosic ethanol fermentation broth by Gluconobacter oxydans.
[So] Source:Bioresour Technol;224:573-580, 2017 Jan.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An oxidative production process of xylonic acid using xylose in distillation stillage of cellulosic ethanol fermentation broth was designed, experimentally investigated, and evaluated. Dry dilute acid pretreated and biodetoxified corn stover was simultaneously saccharified and fermented into 59.80g/L of ethanol (no xylose utilization). 65.39g/L of xylose was obtained in the distillation stillage without any concentrating step after ethanol was distillated. Then the xylose was completely converted into 66.42g/L of xylonic acid by Gluconobacter oxydans. The rigorous Aspen Plus modeling shows that the wastewater generation and energy consumption was significantly reduced comparing to the previous xylonic acid production process using xylose in pretreatment liquid. This study provided a practical process option for xylonic acid production from lignocellulose feedstock with significant reduction of wastewater and energy consumption.
[Mh] Termos MeSH primário: Biotecnologia/métodos
Etanol/metabolismo
Gluconobacter oxydans/metabolismo
Álcoois Açúcares/metabolismo
Zea mays/química
[Mh] Termos MeSH secundário: Destilação
Fermentação
Lignina/química
Lignina/metabolismo
Modelos Teóricos
Oxirredução
Brotos de Planta/química
Brotos de Planta/metabolismo
Ácidos Sulfúricos/química
Águas Residuais
Xilose/metabolismo
Zea mays/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sugar Alcohols); 0 (Sulfuric Acids); 0 (Waste Water); 11132-73-3 (lignocellulose); 3K9958V90M (Ethanol); 9005-53-2 (Lignin); A1TA934AKO (Xylose); O40UQP6WCF (sulfuric acid)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


  10 / 2180 MEDLINE  
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[PMID]:27933453
[Au] Autor:Abe K; Kuroda A; Takeshita R
[Ad] Endereço:Process Development Laboratories, Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-8681, Japan. kenji_abe68@ajinomoto.com.
[Ti] Título:Engineering of Escherichia coli to facilitate efficient utilization of isomaltose and panose in industrial glucose feedstock.
[So] Source:Appl Microbiol Biotechnol;101(5):2057-2066, 2017 Mar.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Industrial glucose feedstock prepared by enzymatic digestion of starch typically contains significant amounts of disaccharides such as maltose and isomaltose and trisaccharides such as maltotriose and panose. Maltose and maltosaccharides can be utilized in Escherichia coli fermentation using industrial glucose feedstock because there is an intrinsic assimilation pathway for these sugars. However, saccharides that contain α-1,6 bonds, such as isomaltose and panose, are still present after fermentation because there is no metabolic pathway for these sugars. To facilitate more efficient utilization of glucose feedstock, we introduced glvA, which encodes phospho-α-glucosidase, and glvC, which encodes a subunit of the phosphoenolpyruvate-dependent maltose phosphotransferase system (PTS) of Bacillus subtilis, into E. coli. The heterologous expression of glvA and glvC conferred upon the recombinant the ability to assimilate isomaltose and panose. The recombinant E. coli assimilated not only other disaccharides but also trisaccharides, including alcohol forms of these saccharides, such as isomaltitol. To the best of our knowledge, this is the first report to show the involvement of the microbial PTS in the assimilation of trisaccharides. Furthermore, we demonstrated that an L-lysine-producing E. coli harboring glvA and glvC converted isomaltose and panose to L-lysine efficiently. These findings are expected to be beneficial for industrial fermentation.
[Mh] Termos MeSH primário: Escherichia coli/genética
Escherichia coli/metabolismo
Glucanos/metabolismo
Glucosiltransferases/genética
Isomaltose/metabolismo
alfa-Glucosidases/genética
[Mh] Termos MeSH secundário: Ração Animal
Glucose/metabolismo
Glucosiltransferases/metabolismo
Lisina/metabolismo
Maltose/metabolismo
Álcoois Açúcares/metabolismo
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucans); 0 (Sugar Alcohols); 33401-87-5 (panose); 67I334IX2M (Isomaltose); 69-79-4 (Maltose); EC 2.4.1.- (Glucosyltransferases); EC 2.4.1.8 (maltose phosphorylase); EC 3.2.1.20 (alpha-Glucosidases); IY9XDZ35W2 (Glucose); K3Z4F929H6 (Lysine); QFA026JZX2 (isomaltitol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170301
[Lr] Data última revisão:
170301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-016-8037-z



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