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[PMID]:27772535
[Au] Autor:Ljungberg M; Nilsson MKL; Melin K; Jönsson L; Carlsson A; Carlsson Å; Forssell-Aronsson E; Ivarsson T; Carlsson M; Starck G
[Ad] Endereço:1Department of Radiation Physics,Institute of Clinical Sciences,Sahlgrenska Academy,University of Gothenburg,Göteborg,Sweden.
[Ti] Título:1H magnetic resonance spectroscopy evidence for occipital involvement in treatment-naive paediatric obsessive-compulsive disorder.
[So] Source:Acta Neuropsychiatr;29(3):179-190, 2017 Jun.
[Is] ISSN:1601-5215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder leading to considerable distress and disability. Therapies are effective in a majority of paediatric patients, however, many only get partial response. It is therefore important to study the underlying pathophysiology of the disorder. METHODS: 1H magnetic resonance spectroscopy (MRS) was used to study the concentration of brain metabolites in four different locations (cingulate gyrus and sulcus, occipital cortex, thalamus and right caudate nucleus). Treatment-naive children and adolescents with OCD (13 subjects) were compared with a group of healthy age- and gender-matched subjects (11 subjects). Multivariate analyses were performed on the concentration values. RESULTS: No separation between controls and patients was found. However, a correlation between metabolite concentrations and symptom severity as measured with the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) was found. Strongest was the correlation with the CY-BOCS obsession subscore and aspartate and choline in the caudate nucleus (positively correlated with obsessions), lipids at 2 and 0.9 ppm in thalamus, and occipital glutamate+glutamine, N-acetylaspartate and myo-inosytol (negatively correlated with obsessions). CONCLUSIONS: The observed correlations between 1H MRS and CY-BOCS in treatment-naive patients further supports an occipital involvement in OCD. The results are consistent with our previous study on adult OCD patients. The 1H MRS data were not supportive of a separation between the patient and control groups.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Transtorno Obsessivo-Compulsivo/diagnóstico por imagem
Transtorno Obsessivo-Compulsivo/metabolismo
Lobo Occipital/diagnóstico por imagem
Espectroscopia de Prótons por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adolescente
Ácido Aspártico/análogos & derivados
Ácido Aspártico/metabolismo
Encéfalo/metabolismo
Criança
Colina/metabolismo
Feminino
Seres Humanos
Inositol/metabolismo
Masculino
Transtorno Obsessivo-Compulsivo/tratamento farmacológico
Transtorno Obsessivo-Compulsivo/fisiopatologia
Lobo Occipital/metabolismo
Índice de Gravidade de Doença
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
30KYC7MIAI (Aspartic Acid); 4L6452S749 (Inositol); 997-55-7 (N-acetylaspartate); N91BDP6H0X (Choline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1017/neu.2016.52


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[PMID]:29360830
[Au] Autor:Sahin K; Orhan C; Tuzcu M; Hayirli A; Komorowski JR; Sahin N
[Ad] Endereço:Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.
[Ti] Título:Effects of dietary supplementation of arginine-silicate-inositol complex on absorption and metabolism of calcium of laying hens.
[So] Source:PLoS One;13(1):e0189329, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effects of supplementation of arginine-silicate-inositol complex (ASI; 49.5-8.2-25 g/kg, respectively) to laying hens were investigated with respect to eggshell quality, calcium (Ca) balance, and expression of duodenal proteins related to Ca metabolism (calbindin and tight junction proteins). A total of 360 laying hens, 25 weeks old, were divided into 3 groups consisting of 6 replicate of cages, 20 birds per cage. The groups were fed a basal diet and the basal diet supplemented with 500 or 1000 mg ASI complex per kilogram for 90 days. Data were analyzed by ANCOVA using data during the first week of the adaptation period as covariates. As the ASI complex supplementation level increased, there were increases in feed intake (P < 0.0001), egg production (P < 0.001), egg weight (P < 0.0001) and eggshell weight (P < 0.001) weight, and shell thickness (P < 0.001) and decreases in feed conversion ratio and cracked egg percentage (P < 0.0001 for both). Concentrations of serum osteocalcin (P < 0.0001), vitamin D (P < 0.0001), calcium (P < 0.001), phosphorus (P < 0.001), and alkaline phosphatase (P < 0.008) as well as amounts of calcium retention (P < 0.0001) and eggshell calcium deposition (P < 0.001), and Ca balance (P < 0.0001) increased, whereas amount of calcium excretion (P < 0.001) decreased linearly in a dose-dependent manner. The ASI complex supplementation increased expressions of calcium transporters (calbindin-D28k, N sodium-calcium exchanger, plasma membrane calcium ATPase, and vitamin D receptor) and tight junction proteins (zonula occludens-1 and occludin) in the duodenum in a linear fashion (P < 0.0001 for all). In conclusion, provision of dietary ASI complex to laying hens during the peak laying period improved eggshell quality through improving calcium utilization as reflected by upregulation of genes related to the calcium metabolism. Further studies are needed to elucidate the contribution of each of the ASI complex ingredients.
[Mh] Termos MeSH primário: Arginina/administração & dosagem
Cálcio/metabolismo
Suplementos Nutricionais
Inositol/administração & dosagem
Silicatos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Galinhas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Silicates); 4L6452S749 (Inositol); 94ZLA3W45F (Arginine); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189329


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[PMID]:29245250
[Au] Autor:Zheng X; Lin D; Zhang Y; Lin Y; Song J; Li S; Sun Y
[Ad] Endereço:Department of Obstetrics and Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
[Ti] Título:Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET.
[So] Source:Medicine (Baltimore);96(49):e8842, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pretreatment of myoinositol is a very new method that was evaluated in multiple small studies to manage poor ovarian response in assisted reproduction. This study was to determine the efficacy of myoinositol supplement in infertile women undergoing ovulation induction for intracytoplasmic sperm injection (ICSI) or in vitro fertilization embryo transfer (IVF-ET). METHODS: A meta-analysis and systematic review of published articles evaluating the efficacy of myo-inositol in patients undergoing ovulation induction for ICSI or IVF-ET was performed. RESULTS: Seven trials with 935 women were included. Myoinositol supplement was associated with significantly improved clinical pregnancy rate [95% confidence interval (CI), 1.04-1.96; P = .03] and abortion rate (95% CI, 0.08-0.50; P = .0006). Meanwhile, Grade 1 embryos proportion (95% CI, 1.10-2.74; P = .02), germinal vescicle and degenerated oocytes retrieved (95% CI, 0.11-0.86; P = .02), and total amount of ovulation drugs (95% CI, -591.69 to -210.39; P = .001) were also improved in favor of myo-inositol. There were no significant difference in total oocytes retrieved, MII stage oocytes retrieved, stimulation days, and E2 peak level. CONCLUSIONS: Myoinositol supplement increase clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET. It may improve the quality of embryos, and reduce the unsuitable oocytes and required amount of stimulation drugs.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Fertilização In Vitro/métodos
Infertilidade Feminina/terapia
Inositol/uso terapêutico
Indução da Ovulação/métodos
[Mh] Termos MeSH secundário: Adulto
Transferência Embrionária
Feminino
Seres Humanos
Oócitos/efeitos dos fármacos
Gravidez
Taxa de Gravidez
Injeções de Esperma Intracitoplásmicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
4L6452S749 (Inositol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008842


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[PMID]:29173209
[Au] Autor:Cowieson AJ; Roos FF; Ruckebusch JP; Wilson JW; Guggenbuhl P; Lu H; Ajuwon KM; Adeola O
[Ad] Endereço:1DSM Nutritional Products,Wurmisweg 576,4303 Kaiseraugst,Switzerland.
[Ti] Título:Time-series responses of swine plasma metabolites to ingestion of diets containing myo-inositol or phytase.
[So] Source:Br J Nutr;118(11):897-905, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of the ingestion of diets containing either myo-inositol or exogenous phytase on plasma metabolites was examined using 29 kg barrows. The diets were: control (maize, soya, rapeseed, rice bran), control plus 2 g/kg myo-inositol, control plus 1000 phytase units (FYT)/kg or 3000 FYT/kg exogenous phytase. Pigs were housed in a PigTurn device and blood was collected, from jugular catheters, via an automated system at -30, (30 min before feeding), 0, 15, 30, 45, 60, 90, 120, 150, 180, 240, 300 and 360 min post-feeding. The addition of 2 g/kg myo-inositol to the basal diet resulted in an increase in plasma myo-inositol concentration that was evident 45-60 min after diet introduction and persisted to 360 min post-feeding. Similarly, supplementation of the basal diet with either 1000 or 3000 FYT/kg exogenous phytase resulted in an increase in plasma myo-inositol concentration that was still rising 360 min post-feeding. Plasma P concentration was increased over time by the addition of 1000 and 3000 FYT/kg phytase, but not by the addition of myo-inositol. Other plasma metabolites examined were not affected by dietary treatment. It can be concluded that oral delivery of myo-inositol results in rapid increase in plasma myo-inositol concentrations that peak approximately 45-60 min after feeding. Use of supplemental phytase achieves similar increases in myo-inositol concentration in plasma but the appearance is more gradual. Furthermore, supplementation of pig diets with exogenous phytase results in rapid appearance of P in plasma that may be sustained over time relative to diets with no added phytase.
[Mh] Termos MeSH primário: 6-Fitase/administração & dosagem
Fenômenos Fisiológicos da Nutrição Animal
Dieta/veterinária
Inositol/administração & dosagem
[Mh] Termos MeSH secundário: 6-Fitase/sangue
Fosfatase Alcalina/sangue
Ração Animal
Animais
Brassica rapa
Fibras na Dieta/administração & dosagem
Suplementos Nutricionais
Inositol/sangue
Feijão de Soja
Suínos
Zea mays
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fiber); 4L6452S749 (Inositol); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.1.3.26 (6-Phytase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003026


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[PMID]:28940006
[Au] Autor:Kokubun T
[Ad] Endereço:Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3AB, UK. t.kokubun@kew.org.
[Ti] Título:Occurrence of myo-inositol and alkyl-substituted polysaccharide in the prey-trapping mucilage of Drosera capensis.
[So] Source:Naturwissenschaften;104(9-10):83, 2017 Sep 22.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The chemical composition of the exudate mucilage droplets of the carnivorous plant Drosera capensis was investigated using nuclear magnetic resonance spectroscopy. The mucilage was found to contain beside a very large molecular weight polysaccharide a significant amount of myo-inositol. It appears that myo-inositol escaped detection due to the commonly applied methodology on the chemical analysis of plant mucilage, such as dialysis, precipitation of polysaccharide component with alcohol, acid hydrolysis and detection of the resultant monosaccharide (aldose) units. The possible functions of myo-inositol in the mucilage droplets and the fate after being washed off from the leaf tentacles are proposed. On the polysaccharide component, the presence of methyl ester and alkyl chain-like moieties could be confirmed. These lipophilic moieties may provide the prey-trapping mucilage with the unique adhesive property onto the hydrophobic insect body parts, as well as onto the nature's well-known superhydrophobic surfaces such as the leaves of the sacred lotus plants. A re-evaluation of the mineral components of the mucilage, reported 40 years ago, is presented from the viewpoints of the current result and plants' natural habitat. A case for re-examination of the well-studied plant mucilaginous materials is made in light of the new findings.
[Mh] Termos MeSH primário: Drosera
[Mh] Termos MeSH secundário: Animais
Inositol
Insetos
Folhas de Planta
Polissacarídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polysaccharides); 4L6452S749 (Inositol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1502-4


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[PMID]:28842444
[Au] Autor:Nedelska Z; Przybelski SA; Lesnick TG; Schwarz CG; Lowe VJ; Machulda MM; Kremers WK; Mielke MM; Roberts RO; Boeve BF; Knopman DS; Petersen RC; Jack CR; Kantarci K
[Ad] Endereço:From the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charl
[Ti] Título:H-MRS metabolites and rate of ß-amyloid accumulation on serial PET in clinically normal adults.
[So] Source:Neurology;89(13):1391-1399, 2017 Sep 26.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess whether noninvasive proton magnetic resonance spectroscopy ( H-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of ß-amyloid (Aß) accumulation on serial PET in clinically normal (CN) older adults. METHODS: Consecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent H-MRS from the posterior cingulate voxel and longitudinal C-Pittsburgh compound B (PiB)-PET were included. The rate of Aß accumulation by serial cortical PiB standardized uptake value ratios was estimated as a function of baseline H-MRS metabolite ratios and time using mixed-effect models adjusted for age, sex, and ε4. Effect of ε4 on the relationship between baseline MRS and an increased rate of Aß accumulation was also assessed. RESULTS: Among all participants, a higher myo-inositol (mI)/creatine ( = 0.011) and a lower -acetylaspartate/mI ( = 0.006) at baseline were associated with an increased Aß accumulation over time after adjusting for age, sex, and ε4. ε4 did not modify the association of baseline H-MRS metabolite ratios and rate of Aß accumulation. However, ε4 carriers accumulated Aß faster than noncarriers regardless of the baseline Aß load ( = 0.001). CONCLUSION: Among CN older adults, early metabolic alterations on H-MRS and ε4 status are independently associated with an increased rate of Aß accumulation. Our findings could have important implications for early diagnosis and identification of individuals for secondary prevention trials, because an increased rate of Aß accumulation in CN older adults may confer a higher risk for cognitive decline and mild cognitive impairment.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/metabolismo
Encéfalo/diagnóstico por imagem
Encéfalo/metabolismo
Tomografia por Emissão de Pósitrons
Espectroscopia de Prótons por Ressonância Magnética
[Mh] Termos MeSH secundário: Idoso
Envelhecimento/metabolismo
Apolipoproteína E4/genética
Ácido Aspártico/análogos & derivados
Ácido Aspártico/metabolismo
Creatina/metabolismo
Feminino
Seguimentos
Heterozigoto
Seres Humanos
Inositol/metabolismo
Estudos Longitudinais
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Apolipoprotein E4); 30KYC7MIAI (Aspartic Acid); 4L6452S749 (Inositol); 997-55-7 (N-acetylaspartate); MU72812GK0 (Creatine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004421


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[PMID]:28817575
[Au] Autor:Yu W; Daniel J; Mehta D; Maddipati KR; Greenberg ML
[Ad] Endereço:Department of Biological Sciences, Wayne State University, Detroit, Michigan, United States of America.
[Ti] Título:MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate.
[So] Source:PLoS One;12(8):e0182534, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myo-inositol, the precursor of all inositol compounds, is essential for the viability of eukaryotes. Identifying the factors that regulate inositol homeostasis is of obvious importance to understanding cell function and the pathologies underlying neurological and metabolic resulting from perturbation of inositol metabolism. The current study identifies Mck1, a GSK3 homolog, as a novel positive regulator of inositol de novo synthesis in yeast. Mck1 was required for normal activity of myo-inositol phosphate synthase (MIPS), which catalyzes the rate-limiting step of inositol synthesis. mck1Δ cells exhibited a 50% decrease in MIPS activity and a decreased rate of incorporation of [13C6]glucose into [13C6]-inositol-3-phosphate and [13C6]-inositol compared to WT cells. mck1Δ cells also exhibited decreased growth in the presence of the inositol depleting drug valproate (VPA), which was rescued by supplementation of inositol. However, in contrast to wild type cells, which exhibited more than a 40% decrease in MIPS activity in the presence of VPA, the drug did not significantly decrease MIPS activity in mck1Δ cells. These findings indicate that VPA-induced MIPS inhibition is Mck1-dependent, and suggest a model that unifies two current hypotheses of the mechanism of action of VPA-inositol depletion and GSK3 inhibition.
[Mh] Termos MeSH primário: Antimaníacos/farmacologia
Inibidores Enzimáticos/farmacologia
Quinase 3 da Glicogênio Sintase/metabolismo
Inositol/metabolismo
Mio-Inositol-1-Fosfato Sintase/metabolismo
Proteínas de Saccharomyces cerevisiae/metabolismo
Ácido Valproico/farmacologia
[Mh] Termos MeSH secundário: Quinase 3 da Glicogênio Sintase/genética
Mio-Inositol-1-Fosfato Sintase/antagonistas & inibidores
Saccharomyces cerevisiae/efeitos dos fármacos
Saccharomyces cerevisiae/genética
Saccharomyces cerevisiae/metabolismo
Proteínas de Saccharomyces cerevisiae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (Enzyme Inhibitors); 0 (Saccharomyces cerevisiae Proteins); 4L6452S749 (Inositol); 614OI1Z5WI (Valproic Acid); EC 2.7.11.26 (Glycogen Synthase Kinase 3); EC 2.7.12.1 (MCK1 protein, S cerevisiae); EC 5.5.1.4 (Myo-Inositol-1-Phosphate Synthase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182534


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[PMID]:28763963
[Au] Autor:Alarcon RT; Gaglieri C; Caires FJ; Magdalena AG; de Castro RAE; Bannach G
[Ad] Endereço:São Paulo State University (UNESP), School of Sciences, Chemistry Department, 17033-260 Bauru, SP, Brazil. Electronic address: turraalarcon@gmail.com.
[Ti] Título:Thermoanalytical study of sweetener myo-inositol: α and ß polymorphs.
[So] Source:Food Chem;237:1149-1154, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work investigates the thermal behavior of α and ß myo-inositol polymorphs. The inositol is a natural compound widely used in the food industry due to its presence in carbohydrate metabolism and its sweet taste. The occurrence of polymorphism could change some physico-chemical properties, such as melting and sublimation temperatures, and solubility. Therefore, the thermal study of polymorphism is important to ensure better conditions for synthesis, storage, and transportation of food that contains the myo-inositol. Simultaneous Termogravimetry-Differential Thermal Analysis, Photovisual Differential Scanning Calorimetry, Polarized Light Thermomicroscopy, and Powder X-ray Diffraction were used in investigation. The data show a new thermal event associated to ß myo-inositol melting at 221.43°C, suggesting that the solid-solid transition at 185.68°C was incomplete. The kinetics data made it possible to determine the transition lifetime of myo-inositol to occur 5% of solid-solid transition at 20°C and 37°C: 126 and 8years, respectively.
[Mh] Termos MeSH primário: Inositol/química
Edulcorantes/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Solubilidade
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sweetening Agents); 4L6452S749 (Inositol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28757134
[Au] Autor:Foster SR; Dilworth LL; Thompson RK; Alexander-Lindo RL; Omoruyi FO
[Ad] Endereço:Department of Basic Medical Sciences, Biochemistry Section, UWI, Mona, Jamaica. Electronic address: shadae.foster@mymona.uwi.edu.
[Ti] Título:Effects of combined inositol hexakisphosphate and inositol supplement on antioxidant activity and metabolic enzymes in the liver of streptozotocin-induced type 2 diabetic rats.
[So] Source:Chem Biol Interact;275:108-115, 2017 Sep 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Diabetes mellitus is associated with elevated reactive oxygen species, lipid abnormalities, reduced antioxidant activity and organ damage. This study examines the effects of combined inositol hexakisphosphate (IP6) and inositol supplement on antioxidant levels and other biochemical parameters in the liver of type 2 diabetic rats. Five groups of Sprague-Dawley rats were studied. Six rats were fed normal diet (non-diabetic control), while 24 rats were fed high-fat diet (HFD) for 4 weeks. Diabetes was induced in 18 of the rats fed HFD by intraperitoneal administration of streptozotocin. The diabetic rats were separated into three groups namely: combined IP6 and inositol, glibenclamide and diabetic control. The non-diabetic group fed high-fat diet was classified as a high-fat control group. For the final four weeks of the experiment, all rats were fed normal diet and given their respective treatment regimes. Hepatic antioxidant status, metabolic enzyme activity, lipid profile, peroxidative damage and liver histology, as well as, serum aminotransferase and alkaline phosphatase activities, and total bilirubin concentration were assessed. Treatment with combined IP6 and inositol supplement significantly increased liver reduced glutathione and high-density lipoprotein levels while liver triglyceride levels and serum alkaline phosphatase activity were significantly reduced by 27%, 50%, 38.5%, and 69.2% respectively compared to the diabetic control. Hepatic superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase activities were significantly upregulated by 55%, 26% and 53% respectively in the diabetic rats treated with combined IP6 and inositol compared to the diabetic control. Combined IP6 and inositol treatment resulted in the preservation of liver cell integrity and improved antioxidant status in type 2 diabetic rats.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Suplementos Nutricionais
Inositol
Fígado/efeitos dos fármacos
Ácido Fítico/farmacologia
Regulação para Cima/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bilirrubina/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/patologia
Ativação Enzimática/efeitos dos fármacos
Glucosefosfato Desidrogenase/metabolismo
Glutationa/metabolismo
Lipoproteínas HDL/metabolismo
Fígado/metabolismo
Fígado/patologia
Masculino
Estresse Oxidativo/efeitos dos fármacos
Oxirredutases/metabolismo
Ratos
Ratos Sprague-Dawley
Estreptozocina/toxicidade
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Lipoproteins, HDL); 0 (Triglycerides); 4L6452S749 (Inositol); 5W494URQ81 (Streptozocin); 7IGF0S7R8I (Phytic Acid); EC 1.- (Oxidoreductases); EC 1.1.1.49 (Glucosephosphate Dehydrogenase); GAN16C9B8O (Glutathione); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE


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[PMID]:28756231
[Au] Autor:Sherr GL; LaMassa N; Li E; Phillips G; Shen CH
[Ad] Endereço:Department of Biology, College of Staten Island, City University of New York, 2800 Victory Blvd, Staten Island, NY 10314, United States; PhD Program in Biology, The Graduate Center, City University of New York, 365 Fifth Avenue, New York 10016, United States.
[Ti] Título:Pah1p negatively regulates the expression of V-ATPase genes as well as vacuolar acidification.
[So] Source:Biochem Biophys Res Commun;491(3):693-700, 2017 Sep 23.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In yeast, PAH1 plays an important role in cell homeostasis and lipid biosynthesis. PAH1 encodes for the PA phosphatase, Pah1p, which is responsible for de novo TAG and phospholipid synthesis. It has been suggested that the lack of Pah1p causes irregular vacuolar morphology and dysfunctional V-ATPase pump activity. However, the molecular connection between Pah1p and V-ATPase activity has remained unclear. Through real-time PCR, we have shown that PAH1 is maximally induced at the stationary stage in the presence of inositol. We also found that vacuoles were less fragmented when PAH1 is maximally expressed. Subsequently, we observed that vacuoles from pah1Δ cells were more acidic than those in WT cells. Furthermore, V-ATPase genes were upregulated in the absence of Pah1p. These results suggest that Pah1p plays an important role in vacuolar activity by negatively regulating the expression of V-ATPase genes. As such, we provide evidence to show the role of Pah1p in vacuolar acidification and fragmentation.
[Mh] Termos MeSH primário: Inositol/metabolismo
Fosfatidato Fosfatase/metabolismo
Proteínas de Saccharomyces cerevisiae/metabolismo
ATPases Vacuolares Próton-Translocadoras/química
ATPases Vacuolares Próton-Translocadoras/metabolismo
Vacúolos/química
Vacúolos/metabolismo
[Mh] Termos MeSH secundário: Regulação para Baixo/fisiologia
Regulação Enzimológica da Expressão Gênica/fisiologia
Concentração de Íons de Hidrogênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saccharomyces cerevisiae Proteins); 4L6452S749 (Inositol); EC 3.1.3.4 (PAH1 protein, S cerevisiae); EC 3.1.3.4 (Phosphatidate Phosphatase); EC 3.6.1.- (Vacuolar Proton-Translocating ATPases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE



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