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[PMID]: 29241319 [Au] Autor: Chen H; Huang J; Shi X; Li Y; Liu Y [Ad] Endereço: School of Food and Biological Engineering, Shaanxi University of Science and Technology Xi?an,China. [Ti] Título: Effects of six substances on the growth and freeze-drying of Lactobacillus delbrueckii subsp. bulgaricus. [So] Source: Acta Sci Pol Technol Aliment;16(4):403-412, 2017 Oct-Dec. [Is] ISSN: 1898-9594 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: BACKGROUND: The efficacy of Lactobacillus delbrueckii subsp. bulgaricus as starter cultures for the dairy industry depends largely on the number of viable and active cells. Freeze-drying is the most convenient and successful method to preserve the bacterial cells. However, not all strains survived during freeze-drying. METHODS: The effects of six substances including NaCl, sorbitol, mannitol, mannose, sodium glutamate, betaine added to the MRS medium on the growth and freeze-drying survival rate and viable counts of Lb. delbrueckii subsp. bulgaricus were studied through a single-factor test and Plackett-Burman design. Subsequently, the optimum freeze-drying conditions of Lb. delbrueckii subsp. bulgaricus were determined. RESULTS: Lb. delbrueckii subsp. bulgaricus survival rates were up to the maximum of 42.7%, 45.4%, 23.6%, while the concentrations of NaCl, sorbitol, sodium glutamate were 0.6%, 0.15%, 0.09%, respectively. In the optimum concentration, the viable counts in broth is 6.1, 6.9, 5.13 (×108 CFU/mL), respectively; the viable counts in freeze-drying power are 3.09, 5.2, 2.7 (×1010 CFU/g), respectively. CONCLUSIONS: Three antifreeze factors including NaCl, sorbitol, sodium glutamate have a positive effect on the growth and freeze-drying of Lb. delbrueckii subsp. bulgaricus. The results are beneficial for developing Lb. delbrueckii subsp. bulgaricus. [Mh] Termos MeSH primário: Crioprotetores/farmacologia Aditivos Alimentares/farmacologia Liofilização Lactobacillus delbrueckii [Mh] Termos MeSH secundário: Betaína/farmacologia Lactobacillus delbrueckii/efeitos dos fármacos Lactobacillus delbrueckii/crescimento & desenvolvimento Manitol/farmacologia Viabilidade Microbiana Cloreto de Sódio/farmacologia Glutamato de Sódio/farmacologia Sorbitol/farmacologia Iogurte/microbiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cryoprotective Agents); 0 (Food Additives); 3OWL53L36A (Mannitol); 3SCV180C9W (Betaine); 451W47IQ8X (Sodium Chloride); 506T60A25R (Sorbitol); W81N5U6R6U (Sodium Glutamate) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180208 [Lr] Data última revisão: 180208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171216 [St] Status: MEDLINE [do] DOI: 10.17306/J.AFS.0512

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[PMID]: 28467199 [Au] Autor: Takenaka T; Kishimoto M; Ohta M; Tomonaga O; Suzuki H [Ad] Endereço: 1 Department of Medicine, International University of Health and Welfare, Clinical Research Center, Sanno Hospital, Tokyo, Japan. [Ti] Título: Sodium-glucose co-transporter type 2 inhibitors reduce evening home blood pressure in type 2 diabetes with nephropathy. [So] Source: Diab Vasc Dis Res;14(3):258-261, 2017 May. [Is] ISSN: 1752-8984 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: The effects of sodium-glucose co-transporter type 2 inhibitors on home blood pressure were examined in type 2 diabetes with nephropathy. METHODS: The patients with diabetic nephropathy were screened from medical records in our hospitals. Among them, 52 patients who measured home blood pressure and started to take sodium-glucose co-transporter type 2 inhibitors were selected. Clinical parameters including estimated glomerular filtration rate, albuminuria and home blood pressure for 6 months were analysed. RESULTS: Sodium-glucose co-transporter type 2 inhibitors (luseogliflozin 5 mg/day or canagliflozin 100 mg/day) reduced body weight, HbA1c, albuminuria, estimated glomerular filtration rate and office blood pressure. Although sodium-glucose co-transporter type 2 inhibitors did not alter morning blood pressure, it reduced evening systolic blood pressure. Regression analyses revealed that decreases in evening blood pressure predicted decrements in albuminuria. CONCLUSION: The present data suggest that sodium-glucose co-transporter type 2 inhibitors suppress sodium overload during daytime to reduce evening blood pressure and albuminuria. [Mh] Termos MeSH primário: Pressão Sanguínea/efeitos dos fármacos Canagliflozina/uso terapêutico Diabetes Mellitus Tipo 2/tratamento farmacológico Nefropatias Diabéticas/prevenção & controle Hipoglicemiantes/uso terapêutico Rim/efeitos dos fármacos Transportador 2 de Glucose-Sódio/antagonistas & inibidores Sorbitol/análogos & derivados [Mh] Termos MeSH secundário: Albuminúria/etiologia Albuminúria/fisiopatologia Albuminúria/prevenção & controle Biomarcadores/sangue Glicemia/efeitos dos fármacos Glicemia/metabolismo Monitorização Ambulatorial da Pressão Arterial Ritmo Circadiano Diabetes Mellitus Tipo 2/sangue Diabetes Mellitus Tipo 2/complicações Diabetes Mellitus Tipo 2/diagnóstico Nefropatias Diabéticas/diagnóstico Nefropatias Diabéticas/etiologia Nefropatias Diabéticas/fisiopatologia Feminino Hemoglobina A Glicada/metabolismo Seres Humanos Rim/fisiopatologia Masculino Registros Médicos Meia-Idade Transportador 2 de Glucose-Sódio/metabolismo Sorbitol/uso terapêutico Fatores de Tempo Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (Hypoglycemic Agents); 0 (SLC5A2 protein, human); 0 (Sodium-Glucose Transporter 2); 0 (hemoglobin A1c protein, human); 0SAC974Z85 (Canagliflozin); 506T60A25R (Sorbitol); C596HWF74Z (1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171219 [Lr] Data última revisão: 171219 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE [do] DOI: 10.1177/1479164117690299

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[PMID]: 29023543 [Au] Autor: Takada T; Sato R; Kikuta S [Ad] Endereço: Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan. [Ti] Título: A mannitol/sorbitol receptor stimulates dietary intake in Tribolium castaneum. [So] Source: PLoS One;12(10):e0186420, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: In insects, perception of chemical stimuli is involved in the acceptance or rejection of food. Gustatory receptors (Grs) that regulate external signals in chemosensory organs have been found in many insects. Tribolium castaneum, a major pest of stored products, possesses over 200 Gr genes. An expanded repertoire of Gr genes appears to be required for diet recognition in species that are generalist feeders; however, it remains unclear whether T. castaneum recognizes a suite of chemicals common to many products or whether its feeding is activated by specific chemicals, and whether its Grs are involved in feeding behavior. It is difficult to determine the food preferences of T. castaneum based on dietary intake due to a lack of appropriate methodology. This study established a novel dietary intake estimation method using gypsum, designated the TribUTE (Tribolium Urges To Eat) assay. For this assay, T. castaneum adults were fed a gypsum block without added organic compounds. Sweet preference was determined by adding sweeteners and measuring the amount of gypsum in the excreta. Mannitol was the strongest activator of T. castaneum dietary intake. In a Xenopus oocyte expression, TcGr20 was found to be responsible for mannitol and sorbitol responses, but not for responses to other tested non-volatile compounds. The EC50 values of TcGr20 for mannitol and sorbitol were 72.6 mM and 90.6 mM, respectively, suggesting that TcGr20 is a feasible receptor for the recognition of mannitol at lower concentrations. We used RNAi and the TribUTE assay to examine whether TcGr20 expression was involved in mannitol recognition. The amounts of excreta in TcGr20 dsRNA-injected adults decreased significantly, despite the presence of mannitol, compared to control adults. Taken together, our results indicate that T. castaneum adults recognized mannitol/sorbitol using the TcGr20 receptor, thereby facilitating the dietary intake of these compounds. [Mh] Termos MeSH primário: Dieta Proteínas de Insetos/metabolismo Receptores de Superfície Celular/metabolismo Tribolium/fisiologia [Mh] Termos MeSH secundário: Animais Expressão Gênica/efeitos dos fármacos Proteínas de Insetos/antagonistas & inibidores Proteínas de Insetos/classificação Proteínas de Insetos/genética Manitol/farmacologia Oócitos/efeitos dos fármacos Oócitos/fisiologia Técnicas de Patch-Clamp Filogenia Interferência de RNA RNA de Cadeia Dupla/metabolismo Receptores de Superfície Celular/antagonistas & inibidores Receptores de Superfície Celular/classificação Receptores de Superfície Celular/genética Sorbitol/farmacologia Tribolium/genética Xenopus/crescimento & desenvolvimento Xenopus/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Proteins); 0 (RNA, Double-Stranded); 0 (Receptors, Cell Surface); 3OWL53L36A (Mannitol); 506T60A25R (Sorbitol) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171105 [Lr] Data última revisão: 171105 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171013 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0186420

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[PMID]: 28823498 [Au] Autor: Ribeiro LS; Órfão JJM; Pereira MFR [Ad] Endereço: Laboratório de Processos de Separação e Reação - Laboratório de Catálise e Materiais (LSRE-LCM), Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. [Ti] Título: Simultaneous catalytic conversion of cellulose and corncob xylan under temperature programming for enhanced sorbitol and xylitol production. [So] Source: Bioresour Technol;244(Pt 1):1173-1177, 2017 Nov. [Is] ISSN: 1873-2976 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Sorbitol and xylitol yields can be improved by converting cellulose and xylan simultaneously, due to a synergetic effect between both substrates. Furthermore, both yields can be greatly enhanced by simply adjusting the reaction conditions regarding the optimum for the production of each product, since xylitol (from xylan) and sorbitol (from cellulose) yields are maximized when the reaction is carried out at 170 and 205°C, respectively. Therefore, the combination of a simultaneous conversion of cellulose and xylan with a two-step temperature approach, which consists in the variation of the reaction temperature from 170 to 205°C after 2h, showed to be a good strategy for maximizing the production of sorbitol and xylitol directly from mixture of cellulose and xylan. Using this new and environmentally friendly approach, yields of sorbitol and xylitol of 75 and 77%, respectively, were obtained after 6h of reaction. [Mh] Termos MeSH primário: Celulose Xilanos Xilitol [Mh] Termos MeSH secundário: Sorbitol Temperatura Ambiente [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Xylans); 506T60A25R (Sorbitol); 9004-34-6 (Cellulose); VCQ006KQ1E (Xylitol) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171023 [Lr] Data última revisão: 171023 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170822 [St] Status: MEDLINE

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[PMID]: 28599861 [Au] Autor: Rathnasekara R; El Rassi Z [Ad] Endereço: Oklahoma State University, Department of Chemistry, Stillwater, OK, 74078-3071, USA. [Ti] Título: Polar silica-based stationary phases. Part II- Neutral silica stationary phases with surface bound maltose and sorbitol for hydrophilic interaction liquid chromatography. [So] Source: J Chromatogr A;1508:24-32, 2017 Jul 28. [Is] ISSN: 1873-3778 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Two neutral polyhydroxylated silica bonded stationary phases, namely maltose-silica (MALT-silica) and sorbitol-silica (SOR-silica), have been introduced and chromatographically characterized in hydrophilic interaction liquid chromatography (HILIC) for a wide range of polar compounds. The bonding of the maltose and sorbitol to the silica surface was brought about by first converting bare silica to an epoxy-activated silica surface via reaction with γ-glycidoxypropyltrimethoxysilane (GPTMS) followed by attaching maltose and sorbitol to the epoxy surface in the presence of the Lewis acid catalyst BF .ethereate. Both silica based columns offered the expected retention characteristics usually encountered for neutral polar surface. The retention mechanism is majorly based on solute' differential partitioning between an organic rich hydro-organic mobile phase (e.g., ACN rich mobile phase) and an adsorbed water layer on the surface of the stationary phase although additional hydrogen bonding was also responsible in some cases for solute retention. The MALT-silica column proved to be more hydrophilic and offered higher retention, separation efficiency and resolution than the SOR-silica column among the tested polar solutes such as derivatized mono- and oligosaccharides, weak phenolic acids, cyclic nucleotide monophosphate and nucleotide-5'-monophosphates, and weak bases, e.g., nucleobases and nucleosides. [Mh] Termos MeSH primário: Cromatografia Líquida/instrumentação Maltose/química Dióxido de Silício/química Sorbitol/química [Mh] Termos MeSH secundário: Adsorção Cromatografia Líquida/métodos Interações Hidrofóbicas e Hidrofílicas Nucleosídeos/química Nucleosídeos/isolamento & purificação Nucleotídeos/química Nucleotídeos/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Nucleosides); 0 (Nucleotides); 506T60A25R (Sorbitol); 69-79-4 (Maltose); 7631-86-9 (Silicon Dioxide) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171107 [Lr] Data última revisão: 171107 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170611 [St] Status: MEDLINE

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[PMID]: 28551219 [Au] Autor: Barbiroli A; Marengo M; Fessas D; Ragg E; Renzetti S; Bonomi F; Iametti S [Ad] Endereço: Section of Chemical and Biomolecular Sciences, DeFENS, Università degli Studi di Milano, Milano, Italy. Electronic address: alberto.barbiroli@unimi.it. [Ti] Título: Stabilization of beta-lactoglobulin by polyols and sugars against temperature-induced denaturation involves diverse and specific structural regions of the protein. [So] Source: Food Chem;234:155-162, 2017 Nov 01. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Temperature sensitivity of bovine milk beta-lactoglobulin (BLG) was assessed in the presence/absence of non-reducing sugars (sucrose and trehalose) and polyols (glycerol and sorbitol). None of them affected the structural features of the protein at room temperature, where the only observed effect was an increased affinity towards hydrophobic probes in the presence of all co-solutes but glycerol. Although most of the observed effects in temperature-ramp experiments are due to entropic effects (fitting within the "preferential exclusion" theory of protein stabilization), this study indicates that each co-solute exhibit different efficacy at stabilizing specific regions of BLG, suggesting that each of them acts in a specific way on the solvent/protein system. The relevance of these observations with respect to systems of practical relevance is discussed, given the widespread use of heat-polymerizing proteins - such as BLG - in many food formulations that very often include significant amounts of sugars and/or polyols. [Mh] Termos MeSH primário: Carboidratos/química Lactoglobulinas/química Desnaturação Proteica Temperatura Ambiente [Mh] Termos MeSH secundário: Animais Bovinos Glicerol Sorbitol [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Carbohydrates); 0 (Lactoglobulins); 506T60A25R (Sorbitol); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170808 [Lr] Data última revisão: 170808 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170529 [St] Status: MEDLINE

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[PMID]: 28510586 [Au] Autor: Wobst HJ; Delsing L; Brandon NJ; Moss SJ [Ad] Endereço: AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, United States of America. [Ti] Título: Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant. [So] Source: PLoS One;12(5):e0177181, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The RNA-binding and -processing protein TAR DNA-binding protein 43 (TDP-43) is heavily linked to the underlying causes and pathology of neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these diseases, TDP-43 is mislocalized, hyperphosphorylated, ubiquitinated, aggregated and cleaved. The importance of TDP-43 cleavage in the disease pathogenesis is still poorly understood. Here we detail the use of D-sorbitol as an exogenous stressor that causes TDP-43 cleavage in HeLa cells, resulting in a 35 kDa truncated product that accumulates in the cytoplasm within one hour of treatment. We confirm that the formation of this 35 kDa cleavage product is mediated by the activation of caspases. Inhibition of caspases blocks the cleavage of TDP-43, but does not prevent the accumulation of full-length protein in the cytoplasm. Using D-sorbitol as a stressor and caspase activator, we also demonstrate that the A90V variant of TDP-43, which lies adjacent to the caspase cleavage site within the nuclear localization sequence of TDP-43, confers partial resistance against caspase-mediated generation of the 35 kDa cleavage product. [Mh] Termos MeSH primário: Códon Proteínas de Ligação a DNA/genética Proteínas de Ligação a DNA/metabolismo Variação Genética [Mh] Termos MeSH secundário: Substituição de Aminoácidos Caspases/metabolismo Citoplasma/metabolismo Proteínas de Ligação a DNA/química Células HeLa Seres Humanos Mutação Pressão Osmótica Estresse Oxidativo Ligação Proteica Domínios e Motivos de Interação entre Proteínas Transporte Proteico/efeitos dos fármacos Proteólise Sorbitol/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Codon); 0 (DNA-Binding Proteins); 0 (TDP-43 protein, human); 506T60A25R (Sorbitol); EC 3.4.22.- (Caspases) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170517 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0177181

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[PMID]: 28490112 [Au] Autor: Harnsoongnoen S; Wanthong A [Ad] Endereço: The Biomimicry for Sustainable Agriculture, Health, Environment and Energy Research Unit, Faculty of Science, Mahasarakham University, 44150 Kantarawichai, Mahasarakham, Thailand. Electronic address: supakorn.ha@gmail.com. [Ti] Título: Real-time monitoring of sucrose, sorbitol, d-glucose and d-fructose concentration by electromagnetic sensing. [So] Source: Food Chem;232:566-570, 2017 Oct 01. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Magnetic sensing at microwave frequencies for real-time monitoring of sucrose, sorbitol, d-glucose and d-fructose concentrations is reported. The sensing element was designed based on a coplanar waveguide (CPW) loaded with a split ring resonator (SRR), which was fabricated on a DiClad 880 substrate with a thickness of 1.6mm and relative permittivity (ε ) of 2.2. The magnetic sensor was connected to a Vector Network Analyzer (VNA) and the electromagnetic interaction between the samples and sensor was analyzed. The magnitude of the transmission coefficient (S ) was used as an indicator to detect the solution sample concentrations ranging from 0.04 to 0.20g/ml. The experimental results confirmed that the developed system using microwaves for the real-time monitoring of sucrose, sorbitol, d-glucose and d-fructose concentrations gave unique results for each solution type and concentration. Moreover, the proposed sensor has a wide dynamic range, high linearity, fast operation and low-cost. [Mh] Termos MeSH primário: Frutose Glucose Sacarose [Mh] Termos MeSH secundário: Fenômenos Eletromagnéticos Sorbitol [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 30237-26-4 (Fructose); 506T60A25R (Sorbitol); 57-50-1 (Sucrose); IY9XDZ35W2 (Glucose) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170731 [Lr] Data última revisão: 170731 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170512 [St] Status: MEDLINE

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[PMID]: 28321056 [Au] Autor: Tosaki T; Kamiya H; Himeno T; Kato Y; Kondo M; Toyota K; Nishida T; Shiroma M; Tsubonaka K; Asai H; Moribe M; Nakaya Y; Nakamura J [Ad] Endereço: TDE Healthcare Corporation TOSAKI Clinic for Diabetes and Endocrinology, Japan. [Ti] Título: Sodium-glucose Co-transporter 2 Inhibitors Reduce the Abdominal Visceral Fat Area and May Influence the Renal Function in Patients with Type 2 Diabetes. [So] Source: Intern Med;56(6):597-604, 2017. [Is] ISSN: 1349-7235 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: Objective and Methods An SGLT2 inhibitor (ipragliflozin, dapagliflozin, luseogliflozin, tofogliflozin, or canagliflozin) was administered to 132 outpatients with type 2 diabetes mellitus with or without other antidiabetic drugs for 6 months to evaluate its efficacy, the incidence of adverse events, and its influence on the renal function. Results The patient's mean glycated hemoglobin level significantly improved from 7.52±1.16% to 6.95±0.98% (p<0.001). The body weight of the patients was significantly reduced from 78.0±15.3 kg to 75.6±15.1 kg (p<0.001). The estimated visceral fat area was also significantly reduced from 108.4±44.6 cm to 94.5±45.3 cm (p<0.001). The waist circumference, blood pressure, serum alanine aminotransferase, γ-glutamyl transpeptidase, and uric acid levels also showed a significant decrease. The urinary albumin/creatinine ratio (U-ACR) was significantly reduced in the patients whose U-ACR levels were 30-300 mg/gCr at the baseline. The mean eGFR significantly decreased in the patients with a pre-treatment eGFR value of ≥90 mL/min/1.73 m but remained unchanged in the patients with a pre-treatment value of <90 mL/min/1.73 m . A total of 13 adverse events were noted, including systemic eruption (n=1), cystitis (n=2), pudendal pruritus (n=2), nausea (n=1), malaise (n=1), a strong hunger sensation and increased food ingestion (n=1), and non-serious hypoglycemia (n=5). Conclusion SGLT2 inhibitors seemed to be useful in the treatment of obese type 2 diabetes mellitus patients. Furthermore, these data suggest that SGLT2 inhibitors may protect the renal function. [Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/tratamento farmacológico Hipoglicemiantes/farmacologia Hipoglicemiantes/uso terapêutico Gordura Intra-Abdominal/efeitos dos fármacos Transportador 2 de Glucose-Sódio/antagonistas & inibidores [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Compostos Benzidrílicos/farmacologia Compostos Benzidrílicos/uso terapêutico Pressão Sanguínea/efeitos dos fármacos Composição Corporal/efeitos dos fármacos Peso Corporal Canagliflozina/farmacologia Canagliflozina/uso terapêutico Diabetes Mellitus Tipo 2/sangue Feminino Taxa de Filtração Glomerular/efeitos dos fármacos Glucosídeos/farmacologia Glucosídeos/uso terapêutico Hemoglobina A Glicada Seres Humanos Gordura Intra-Abdominal/fisiopatologia Testes de Função Renal Masculino Meia-Idade Sorbitol/análogos & derivados Sorbitol/farmacologia Sorbitol/uso terapêutico Tiofenos/farmacologia Tiofenos/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol); 0 (6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol); 0 (Benzhydryl Compounds); 0 (Glucosides); 0 (Glycated Hemoglobin A); 0 (Hypoglycemic Agents); 0 (Sodium-Glucose Transporter 2); 0 (Thiophenes); 0SAC974Z85 (Canagliflozin); 3N2N8OOR7X (ipragliflozin); 506T60A25R (Sorbitol); C596HWF74Z (1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170322 [St] Status: MEDLINE [do] DOI: 10.2169/internalmedicine.56.7196

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[PMID]: 28283753 [Au] Autor: Ma H; Xu J; DaSilva NA; Wang L; Wei Z; Guo L; Johnson SL; Lu W; Xu J; Gu Q; Seeram NP [Ad] Endereço: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, 02881, USA. hang_ma@uri.edu. [Ti] Título: Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells. [So] Source: Arch Dermatol Res;309(4):265-274, 2017 May. [Is] ISSN: 1432-069X [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The red maple (Acer rubrum) is a rich source of phenolic compounds which possess galloyl groups attached to different positions of a 1,5-anhydro-D-glucitol core. While these glucitol-core containing gallotannins (GCGs) have reported anti-oxidant and anti-glycative effects, they have not yet been evaluated for their cosmetic applications. Herein, the anti-tyrosinase and anti-melanogenic effects of a proprietary phenolic-enriched red maple leaves extract [Maplifa ; contains ca. 45% ginnalin A (GA) along with other GCGs] were investigated using enzyme and cellular assays. The GCGs showed anti-tyrosinase activity with IC values ranging from 101.4 to 1047.3 µM and their mechanism of tyrosinase inhibition (using GA as a representative GCG) was evaluated by chelating and computational/modeling studies. GA reduced melanin content in murine melanoma B16F10 cells by 79.1 and 56.7% (at non-toxic concentrations of 25 and 50 µM, respectively), and its mechanisms of anti-melanogenic effects were evaluated by using methods including fluorescent probe (DCF-DA), real-time PCR, and western blot experiments. These data indicated that GA was able to: (1) reduce the levels of reactive oxygen species, (2) down-regulate the expression of MITF, TYR, TRP-1, and TRP-2 gene levels in a time-dependent manner, and (3) significantly reduce protein expression of the TRP-2 gene. Therefore, the anti-melanogenic effects of red maple GCGs warrant further investigation of this proprietary natural product extract for potential cosmetic applications. [Mh] Termos MeSH primário: Acer/imunologia Taninos Hidrolisáveis/uso terapêutico Oxirredutases Intramoleculares/metabolismo Melanócitos/efeitos dos fármacos Extratos Vegetais/uso terapêutico Neoplasias Cutâneas/tratamento farmacológico Sorbitol/uso terapêutico [Mh] Termos MeSH secundário: Animais Proliferação Celular/efeitos dos fármacos Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos Seres Humanos Taninos Hidrolisáveis/química Oxirredutases Intramoleculares/genética Melaninas/metabolismo Melanócitos/fisiologia Melanoma Experimental Camundongos Fenóis/química Extratos Vegetais/química Folhas de Planta Sorbitol/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hydrolyzable Tannins); 0 (Melanins); 0 (Phenols); 0 (Plant Extracts); 506T60A25R (Sorbitol); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.3.12 (dopachrome isomerase) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170421 [Lr] Data última revisão: 170421 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170312 [St] Status: MEDLINE [do] DOI: 10.1007/s00403-017-1728-1

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