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[PMID]: 29377914 [Au] Autor: Grasso R; Musumeci F; Gulino M; Scordino A [Ad] Endereço: Department of Physics and Astronomy, Catania University, Catania, Italy. [Ti] Título: Exploring the behaviour of water in glycerol solutions by using delayed luminescence. [So] Source: PLoS One;13(1):e0191861, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The crucial role of water in the engine of life have encouraged many researchers in studying, both theoretically and experimentally, the possible "structure" of water. Many properties of water have been related to the interplay between two distinct and interconverting structural species, namely the low-density water (LDW) and the high-density water (HDW). Supported by the results obtained with other aqueous solutions, this paper deals with the possibility of using the ultra-weak delayed luminescence (DL) to investigate water structuring in a mixture with glycerol, characterized only by hydrogen bonds between the various molecules. Spectral and temporal characteristics of DL decays give information on the two components of the mixture, by evidencing the contribution of water at glycerol concentrations close to the values used in cryopreservation. DL results have shown a correlation with LDW clusters size as determined by other researchers on the basis of neutron diffraction experiments and computational modelling, as reported in Literature. [Mh] Termos MeSH primário: Glicerol/química Água/química [Mh] Termos MeSH secundário: Luminescência Soluções Análise Espectral [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Solutions); 059QF0KO0R (Water); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180130 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191861

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[PMID]: 29367483 [Au] Autor: Matsuura T; Ogawa A; Ohara Y; Nishina S; Nakanishi M; Gohtani S [Ad] Endereço: Department of Applied Biological Science, Kagawa University. [Ti] Título: Effect of Alcohols on the Phase Behavior and Emulsification of a Sucrose Fatty Acid Ester/Water/Edible Oil System. [So] Source: J Oleo Sci;67(2):167-176, 2018 Feb 01. [Is] ISSN: 1347-3352 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: The effect of alcohols (ethanol, 1-propanol, propylene glycol, glycerin, sucrose) on the phase behavior and emulsification of sucrose stearic acid ester (SSE)/water/edible vegetable oil (EVO) systems was investigated. Adding sucrose, propylene glycol, and glycerin narrowed the oil-separated two-phase region in the phase diagram of the SSE/water/EVO systems, whereas adding ethanol and 1-propanol expanded the oil-separated two-phase region. Changing the course of emulsification in the phase diagram showed that the size of the oil-droplet particle typically decreased in a system with a narrowed oil-separated region. The emulsification properties of the systems varied with respect to changes in the phase diagram. The microstructure of the systems was examined using small-angle X-ray scattering, and the ability to retain the oil in the lamellar structure of the SSEs was suggested as an important role in emulsification, because the mechanism of the systems was the same as that for the liquid crystal emulsification method. [Mh] Termos MeSH primário: Álcoois/química Ésteres/química Ácidos Graxos/química Transição de Fase Óleos Vegetais/química Ácidos Esteáricos/química Sacarose/química Água/química [Mh] Termos MeSH secundário: Emulsões Glicerol/química Propilenoglicol/química Espalhamento a Baixo Ângulo Difração de Raios X [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Alcohols); 0 (Emulsions); 0 (Esters); 0 (Fatty Acids); 0 (Plant Oils); 0 (Stearic Acids); 059QF0KO0R (Water); 4ELV7Z65AP (stearic acid); 57-50-1 (Sucrose); 6DC9Q167V3 (Propylene Glycol); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180126 [St] Status: MEDLINE [do] DOI: 10.5650/jos.ess17146

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[PMID]: 28450249 [Au] Autor: Kurt A; Toker OS; Tornuk F [Ad] Endereço: Department of Food Engineering, Engineering Faculty, Ondokuz Mayis University, 55139, Samsun, Turkey; Department of Food Engineering, Engineering and Architecture Faculty, Bitlis Eren University, 13000 Bitlis, Turkey. Electronic address: abdullahkurt48@gmail.com. [Ti] Título: Effect of xanthan and locust bean gum synergistic interaction on characteristics of biodegradable edible film. [So] Source: Int J Biol Macromol;102:1035-1044, 2017 Sep. [Is] ISSN: 1879-0003 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The present study was aimed to use different combinations of xanthan (XG) and locust bean gum (LBG) in the biodegradable edible film preparation by benefitting from their synergistic interactions for the first time. Concentrations of LBG, XG and glycerol of the optimized film sample were found to be 89.6%, 10.4% and 20%, respectively. At the optimum point the WVP, TS, E% and EM values of film were found 0.22gmmh m kPa, 86.97MPa, 33.34% and 177.25MPa, respectively. The optimized film was characterized for its physical, thermal and structural behavior. The scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FTIR) analyses exhibited miscibility and presence of interaction between polymers. In conclusion, XG and LBG interaction was used successfully to get biodegradable films and coatings with improved characteristics. [Mh] Termos MeSH primário: Materiais Biocompatíveis/química Galactanos/química Mananas/química Gomas Vegetais/química Polissacarídeos Bacterianos/química Embalagem de Produtos [Mh] Termos MeSH secundário: Materiais Biocompatíveis/metabolismo Composição de Medicamentos Glicerol/química Fenômenos Mecânicos Permeabilidade Reologia Vapor Temperatura Ambiente [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biocompatible Materials); 0 (Galactans); 0 (Mannans); 0 (Plant Gums); 0 (Polysaccharides, Bacterial); 0 (Steam); PDC6A3C0OX (Glycerol); TTV12P4NEE (xanthan gum); V4716MY704 (locust bean gum) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28470142 [Au] Autor: Nordlund M; Belka M; Kuczaj AK; Lizal F; Jedelsky J; Elcner J; Jicha M; Sauser Y; Le Bouhellec S; Cosandey S; Majeed S; Vuillaume G; Peitsch MC; Hoeng J [Ad] Endereço: a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland. [Ti] Título: Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract. [So] Source: Inhal Toxicol;29(3):113-125, 2017 02. [Is] ISSN: 1091-7691 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Inhalation of aerosols generated by electronic cigarettes leads to deposition of multiple chemical compounds in the human airways. In this work, an experimental method to determine regional deposition of multicomponent aerosols in an in vitro segmented, realistic human lung geometry was developed and applied to two aerosols, i.e. a monodisperse glycerol aerosol and a multicomponent aerosol. The method comprised the following steps: (1) lung cast model preparation, (2) aerosol generation and exposure, (3) extraction of deposited mass, (4) chemical quantification and (5) data processing. The method showed good agreement with literature data for the deposition efficiency when using a monodisperse glycerol aerosol, with a mass median aerodynamic diameter (MMAD) of 2.3 µm and a constant flow rate of 15 L/min. The highest deposition surface density rate was observed in the bifurcation segments, indicating inertial impaction deposition. The experimental method was also applied to the deposition of a nebulized multicomponent aerosol with a MMAD of 0.50 µm and a constant flow rate of 15 L/min. The deposited amounts of glycerol, propylene glycol and nicotine were quantified. The three analyzed compounds showed similar deposition patterns and fractions as for the monodisperse glycerol aerosol, indicating that the compounds most likely deposited as parts of the same droplets. The developed method can be used to determine regional deposition for multicomponent aerosols, provided that the compounds are of low volatility. The generated data can be used to validate aerosol deposition simulations and to gain insight in deposition of electronic cigarette aerosols in human airways. [Mh] Termos MeSH primário: Aerossóis/farmacocinética Modelos Anatômicos Sistema Respiratório/metabolismo [Mh] Termos MeSH secundário: Administração por Inalação Glicerol/farmacocinética Seres Humanos Tamanho da Partícula [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Aerosols); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1080/08958378.2017.1315196

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[PMID]: 29202488 [Au] Autor: Ceci R; Duranti G; Sgrò P; Sabatini S; Di Luigi L [Ad] Endereço: Università degli Studi di Roma "Foro Italico", Department of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, Rome, Italy. [Ti] Título: Acute tadalafil administration increases plasma fatty acids without changes in the inflammatory response in healthy men. [So] Source: Acta Biochim Pol;64(4):687-691, 2017. [Is] ISSN: 1734-154X [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: PURPOSE: Tadalafil, the phosphodiesterase type 5 inhibitor (PDE5I), has been shown to reduce visceral adipose tissue in rabbit and to improve lean mass content in non-obese men. In order to clarify this effect in humans, in the present study we determined the impact of an acute oral tadalafil administration on lipolysis by evaluating plasma free fatty acids (FFAs) and glycerol. FFAs are potential modulator of inflammation response that we evaluated through tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), interleukin 8 (IL8) and interleukin 10 (IL10) plasma levels. Moreover, we determined whether the effects of tadalafil would be reflected in variation of plasma levels of cGMP and NO, two important molecules involved in PDE5Is signaling. METHODS: Twelve healthy subjects were supplemented with 20 mg of tadalafil or a placebo, in a double-blind, randomized, cross-over design. Blood samples were collected immediately before, and at 2, 6, and 24 hours post ingestion, and assayed for biochemical analysis. RESULTS: A condition effect was noted for FFAs and glycerol, with values higher for tadalafil when compared to the placebo group, at 2 and 6 hours post ingestion. No statistically significant effects were noted for glucose, cGMP, nitrate and nitrite. No inflammatory response was induced by tadalafil. CONCLUSION: Tadalafil, in human subjects, increases lipolysis as evidenced by a significant increase in circulating FFAs and glycerol, without affecting the plasma cGMP and NO levels; noticeably, the increase in FFAs did not develop an inflammatory response. Further well-controlled studies are warranted to assess the impact of tadalafil administration on weight/fat loss. [Mh] Termos MeSH primário: Ácidos Graxos/sangue Inflamação/sangue Inibidores da Fosfodiesterase 5/administração & dosagem Tadalafila/administração & dosagem [Mh] Termos MeSH secundário: Adulto Glicemia/metabolismo GMP Cíclico/sangue Método Duplo-Cego Glicerol/sangue Seres Humanos Interleucina-6/sangue Interleucina-8/sangue Masculino Óxido Nítrico/sangue Fator de Necrose Tumoral alfa/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Blood Glucose); 0 (Fatty Acids); 0 (IL6 protein, human); 0 (IL8 protein, human); 0 (Interleukin-6); 0 (Interleukin-8); 0 (Phosphodiesterase 5 Inhibitors); 0 (Tumor Necrosis Factor-alpha); 31C4KY9ESH (Nitric Oxide); 742SXX0ICT (Tadalafil); H2D2X058MU (Cyclic GMP); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171205 [St] Status: MEDLINE [do] DOI: 10.18388/abp.2017_2205

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[PMID]: 28464466 [Au] Autor: Jiang Z; Zhang Z; Wu T; Zhang P; Song J; Xie C; Han B [Ad] Endereço: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. [Ti] Título: Efficient Generation of Lactic Acid from Glycerol over a Ru-Zn-Cu /Hydroxyapatite Catalyst. [So] Source: Chem Asian J;12(13):1598-1604, 2017 Jul 04. [Is] ISSN: 1861-471X [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The biodiesel production process generates a significant amount of glycerol as a byproduct. A drive to add value has attracted worldwide attention, with the aim of improving the overall effectiveness and profitability of biodiesel production. Herein, we report hydroxyapatite (HAP)-supported Ru-Zn-Cu (Ru-Zn-Cu /HAP) as effective catalysts for the transformation of glycerol to lactic acid (LA).The catalysts were characterized by using different techniques. The effects of catalyst composition, reaction time, and temperature on the conversion and product distribution were investigated. It was revealed that Ru nanoparticles of less than 2 nm were dispersed uniformly on HAP. Cu could effectively inhibit the cleavage of C-C bonds, which led to improved yields of LA. Under optimized conditions, the yield of LA could reach 70.9 % over Ru-Zn-Cu /HAP. Furthermore, the catalyst could be reused at least four times without an obvious loss of activity or selectivity. [Mh] Termos MeSH primário: Cobre/química Durapatita/química Glicerol/química Ácido Láctico/síntese química Rutênio/química Zinco/química [Mh] Termos MeSH secundário: Catálise Ácido Láctico/química Tamanho da Partícula Propriedades de Superfície [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 33X04XA5AT (Lactic Acid); 789U1901C5 (Copper); 7UI0TKC3U5 (Ruthenium); 91D9GV0Z28 (Durapatite); J41CSQ7QDS (Zinc); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1002/asia.201700412

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[PMID]: 28668640 [Au] Autor: Mak PJ; Denisov IG [Ad] Endereço: Department of Chemistry, Saint Louis University, St. Louis, MO, United States. Electronic address: makp@slu.edu. [Ti] Título: Spectroscopic studies of the cytochrome P450 reaction mechanisms. [So] Source: Biochim Biophys Acta;1866(1):178-204, 2018 01. [Is] ISSN: 0006-3002 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often under physiological conditions, catalyze many distinct oxidative transformations on a wide variety of molecules, including relatively simple alkanes or fatty acids, as well as more complex compounds such as steroids and exogenous pollutants. They perform such impressive chemistry utilizing a sophisticated catalytic cycle that involves a series of consecutive chemical transformations of heme prosthetic group. Each of these steps provides a unique spectral signature that reflects changes in oxidation or spin states, deformation of the porphyrin ring or alteration of dioxygen moieties. For a long time, the focus of cytochrome P450 research was to understand the underlying reaction mechanism of each enzymatic step, with the biggest challenge being identification and characterization of the powerful oxidizing intermediates. Spectroscopic methods, such as electronic absorption (UV-Vis), electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), electron nuclear double resonance (ENDOR), Mössbauer, X-ray absorption (XAS), and resonance Raman (rR), have been useful tools in providing multifaceted and detailed mechanistic insights into the biophysics and biochemistry of these fascinating enzymes. The combination of spectroscopic techniques with novel approaches, such as cryoreduction and Nanodisc technology, allowed for generation, trapping and characterizing long sought transient intermediates, a task that has been difficult to achieve using other methods. Results obtained from the UV-Vis, rR and EPR spectroscopies are the main focus of this review, while the remaining spectroscopic techniques are briefly summarized. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. [Mh] Termos MeSH primário: Sistema Enzimático do Citocromo P-450/química Heme/química Ferro/química Oxigênio/química [Mh] Termos MeSH secundário: Biocatálise Espectroscopia de Ressonância de Spin Eletrônica/instrumentação Espectroscopia de Ressonância de Spin Eletrônica/métodos Radicais Livres/química Congelamento Glicerol/química Espectroscopia de Ressonância Magnética/instrumentação Espectroscopia de Ressonância Magnética/métodos Modelos Moleculares Oxirredução Estrutura Secundária de Proteína Análise Espectral Raman/instrumentação Análise Espectral Raman/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW [Nm] Nome de substância: 0 (Free Radicals); 42VZT0U6YR (Heme); 9035-51-2 (Cytochrome P-450 Enzyme System); E1UOL152H7 (Iron); PDC6A3C0OX (Glycerol); S88TT14065 (Oxygen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180208 [Lr] Data última revisão: 180208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170703 [St] Status: MEDLINE

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[PMID]: 29250551 [Au] Autor: Naspolini BF; Machado ACO; Cravo Junior WB; Freire DMG; Cammarota MC [Ad] Endereço: National Institute of Technology (INT-MCTIC), Av. Venezuela, No. 82, Centro, 22453-900 Rio de Janeiro, RJ, Brazil. [Ti] Título: Bioconversion of Sugarcane Vinasse into High-Added Value Products and Energy. [So] Source: Biomed Res Int;2017:8986165, 2017. [Is] ISSN: 2314-6141 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Vinasse, a residue from bioethanol production containing high organic matter concentration, was used as substrate in submerged fermentation of PA1 for biosurfactant production. About 2.7 g/L of rhamnolipids was obtained, with surface tension of 29.2 mN/m and critical micelle concentration of 80.3 mg/L. After separation of rhamnolipid and biomass, residual fermentation media were submitted to anaerobic biodegradation in mesophilic conditions. The residual medium derived from fermentation with vinasse diluted to 1 : 1, without addition of nitrogen, C : N 21, and for 168 h, led to 63.2% chemical oxygen demand (COD) removal and 97.6 mL CH /g COD . Compared to results obtained with fresh vinasse (73.7% COD removal and 112.4 mL CH /g COD ), it could be concluded that both processes can be integrated in order to add value to the residue and obtain energy, reducing production costs and at the same time environmental impacts related to vinasse disposal. [Mh] Termos MeSH primário: Biocombustíveis Reatores Biológicos Saccharum/química [Mh] Termos MeSH secundário: Análise da Demanda Biológica de Oxigênio Biomassa Fermentação Glicerol/metabolismo Glicolipídeos/metabolismo Nitrogênio/metabolismo Pseudomonas aeruginosa/metabolismo Tensoativos/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biofuels); 0 (Glycolipids); 0 (Surface-Active Agents); 0 (rhamnolipid); N762921K75 (Nitrogen); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180129 [Lr] Data última revisão: 180129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171219 [St] Status: MEDLINE [do] DOI: 10.1155/2017/8986165

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[PMID]: 29227084 [Au] Autor: Gudkova OO; Latyshko NV; Shandrenko SG [Ti] Título: Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats. [So] Source: Ukr Biochem J;88(1):79-87, 2016 Jan-Feb. [Is] ISSN: 2409-4943 [Cp] País de publicação: Ukraine [La] Idioma: eng [Ab] Resumo: In this study we have tested an idea on the important role of amine oxidases (semicarbazide-sensitive amine oxidase, diamine oxidase, polyamine oxidase) as an additional source of oxidative/carbonyl stress under glycerol-induced rhabdomyolysis, since the enhanced formation of reactive oxygen species and reactive carbonyl species in a variety of tissues is linked to various diseases. In our experiments we used the sensitive fluorescent method devised for estimation of amine oxidases activity in the rat kidney and thymus as targeted organs under rhabdomyolysis. We have found in vivo the multiple rises in activity of semicarbazide-sensitive amine oxidase, diamine oxidase, polyamine oxidase (2-4.5 times) in the corresponding cell fractions, whole cells or their lysates at the 3-6th day after glycerol injection. Aberrant antioxidant activities depended on rhabdomyolysis stage and had organ specificity. Additional treatment of animals with metal chelator 'Unithiol' adjusted only the activity of antioxidant enzymes but not amine oxidases in both organs. Furthermore the in vitro experiment showed that Fenton reaction (hydrogen peroxide in the presence of iron) products alone had no effect on semicarbazide-sensitive amine oxidase activity in rat liver cell fraction whereas supplementation with methylglyoxal resulted in its significant 2.5-fold enhancement. Combined action of the both agents had additive effect on semicarbazide-sensitive amine oxidase activity. We can assume that biogenic amine and polyamine catabolism by amine oxidases is upregulated by oxidative and carbonyl stress factors directly under rhabdomyolysis progression, and the increase in catabolic products concentration contributes to tissue damage in glycerol-induced acute renal failure and apoptosis stimulation in thymus. [Mh] Termos MeSH primário: Amina Oxidase (contendo Cobre)/metabolismo Monoaminoxidase/metabolismo Oxirredutases atuantes sobre Doadores de Grupo CH-NH/metabolismo Espécies Reativas de Oxigênio/metabolismo Rabdomiólise/enzimologia [Mh] Termos MeSH secundário: Animais Quelantes/farmacologia Glicerol Hepatócitos/efeitos dos fármacos Hepatócitos/enzimologia Hepatócitos/patologia Peróxido de Hidrogênio/antagonistas & inibidores Peróxido de Hidrogênio/farmacologia Rim/efeitos dos fármacos Rim/enzimologia Rim/patologia Fígado/efeitos dos fármacos Fígado/enzimologia Fígado/patologia Masculino Especificidade de Órgãos Oxirredução Carbonilação Proteica Aldeído Pirúvico/antagonistas & inibidores Aldeído Pirúvico/farmacologia Ratos Ratos Wistar Rabdomiólise/induzido quimicamente Rabdomiólise/tratamento farmacológico Rabdomiólise/patologia Semicarbazidas/antagonistas & inibidores Semicarbazidas/farmacologia Timo/efeitos dos fármacos Timo/enzimologia Timo/patologia Unitiol/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Chelating Agents); 0 (Reactive Oxygen Species); 0 (Semicarbazides); 37QUC23K2X (carbamylhydrazine); 4076-02-2 (Unithiol); 722KLD7415 (Pyruvaldehyde); BBX060AN9V (Hydrogen Peroxide); EC 1.4.3.21 (Amine Oxidase (Copper-Containing)); EC 1.4.3.4 (Monoamine Oxidase); EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors); EC 1.5.3.- (polyamine oxidase); PDC6A3C0OX (Glycerol) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171212 [St] Status: MEDLINE [do] DOI: 10.15407/ubj88.01.079

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[PMID]: 28463899 [Au] Autor: Gao Y; Silvennoinen M; Pesola AJ; Kainulainen H; Cronin NJ; Finni T [Ad] Endereço: Neuromuscular Research Center, Biology of Physical Activity, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND. [Ti] Título: Acute Metabolic Response, Energy Expenditure, and EMG Activity in Sitting and Standing. [So] Source: Med Sci Sports Exerc;49(9):1927-1934, 2017 Sep. [Is] ISSN: 1530-0315 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: While merely standing up interrupts sedentary behavior, it is important to study acute metabolic responses during single bouts of sitting and standing to understand the physiological processes affecting the health of office workers. METHODS: Eighteen healthy middle-age women 49.4 ± 7.9 yr old (range: 40-64) with a body mass index of 23.4 ± 2.8 kg·m volunteered for this laboratory-based randomized crossover trial where they performed 2 h desk work in either sitting or standing postures after overnight fasting. Muscle activity (normalized to walking at 5 km·h), respiratory gas exchange, and blood samples were assessed after glucose loading (75 g). RESULTS: Compared with seated work, continuous standing resulted in greater activity in the thigh muscles (mean of biceps femoris and vastus lateralis: 17% ± 8% vs 7% ± 2%, P < 0.001) and leg muscles (mean of tibialis anterior, gastrocnemius medialis, and soleus: 16% ± 6% vs 7% ± 3%, P < 0.001), but no increases in back muscle activity (thoracic erector spinae, lumbar erector spinae, and multifidus). Concomitant with 9% higher energy expenditure (EE) (P = 0.002), standing resulted in higher fat oxidation (48% ± 9% EE vs 39% ± 7% EE, P = 0.008) and lower carbohydrate oxidation (52% ± 9% EE vs 61% ± 7% EE, P = 0.008) than sitting. Glucose total and net incremental area under the curve were approximately 10% (P = 0.026) and 42% (P = 0.017) higher during standing than sitting, respectively. Insulin concentration did not differ between conditions. CONCLUSION: Compared with sitting, 2 h of standing increased muscle activity, fat oxidation, and circulating glucose level. These results suggest fuel switching in favor of fat oxidation during standing despite extra carbohydrate availability. [Mh] Termos MeSH primário: Metabolismo Energético/fisiologia Músculo Esquelético/fisiologia Postura/fisiologia [Mh] Termos MeSH secundário: Adulto Glicemia/metabolismo Estudos Cross-Over Eletromiografia Feminino Glicerol/sangue Seres Humanos Hidrocortisona/sangue Insulina/sangue Lipídeos/sangue Meia-Idade Oxirredução Troca Gasosa Pulmonar/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Blood Glucose); 0 (Insulin); 0 (Lipids); PDC6A3C0OX (Glycerol); WI4X0X7BPJ (Hydrocortisone) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180108 [Lr] Data última revisão: 180108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1249/MSS.0000000000001305

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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