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Pesquisa : D02.047.122 [Categoria DeCS]
Referências encontradas : 2528 [refinar]
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[PMID]:29306845
[Au] Autor:He TF; Zhang ZH; Zeng XA; Wang LH; Brennan CS
[Ad] Endereço:School of Food Sciences and Engineering, South China University of Technology, Guangzhou 510641, China; Food Green Processing and Nutrition Regulation Research Center of Guangdong Province, China.
[Ti] Título:Determination of membrane disruption and genomic DNA binding of cinnamaldehyde to Escherichia coli by use of microbiological and spectroscopic techniques.
[So] Source:J Photochem Photobiol B;178:623-630, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This work was aimed to investigate the antibacterial action of cinnamaldehyde (CIN) against Escherichia coli ATCC 8735 (E. coli) based on membrane fatty acid composition analysis, alterations of permeability and cell morphology as well as interaction with genomic DNA. Analysis of membrane fatty acids using gas chromatography-mass spectrometry (GC-MS) revealed that the proportion of unsaturated fatty acids (UFA) and saturated fatty acids (SFA) were the major fatty acids in plasmic membrane, and their levels were significantly changed after exposure of E. coli to CIN at low concentrations. For example, the proportion of UFA decreased from 39.97% to 20.98%, while the relative content of SFA increased from 50.14% to 67.80% as E. coli was grown in increasing concentrations of CIN (from 0 to 0.88mM). Scanning electron microscopy (SEM) showed that the morphology of E. coli cells to be wrinkled, distorted and even lysed after exposure to CIN, which therefore decreased the cell viability. The binding of CIN to genomic DNA was probed using fluorescence, UV-Visible absorption spectra, circular dichroism, molecular modeling and atomic force microscopy (AFM). Results indicated that CIN likely bound to the minor groove of genomic DNA, and changed the secondary structure and morphology of this biomacromolecule. Therefore, CIN can be deem as a kind of natural antimicrobial agents, which influence both cell membrane and genomic DNA.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Antibacterianos/química
Parede Celular/metabolismo
DNA/química
[Mh] Termos MeSH secundário: Acroleína/química
Acroleína/metabolismo
Acroleína/farmacologia
Antibacterianos/metabolismo
Antibacterianos/farmacologia
Sítios de Ligação
Dicroísmo Circular
DNA/metabolismo
Escherichia coli/efeitos dos fármacos
Escherichia coli/metabolismo
Ácidos Graxos/análise
Ácidos Graxos Insaturados/análise
Cromatografia Gasosa-Espectrometria de Massas
Microscopia de Força Atômica
Microscopia Eletrônica de Varredura
Simulação de Acoplamento Molecular
Conformação de Ácido Nucleico
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fatty Acids); 0 (Fatty Acids, Unsaturated); 7864XYD3JJ (Acrolein); 9007-49-2 (DNA); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180108
[St] Status:MEDLINE


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[PMID]:28958934
[Au] Autor:Tian F; Yu CT; Ye WD; Wang Q
[Ad] Endereço:State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan Road, Xiamen, Fujian 361000, China; Department of Respiratory Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanji
[Ti] Título:Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer.
[So] Source:Biochem Biophys Res Commun;493(3):1260-1266, 2017 Nov 25.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cinnamaldehyde (CA), the primary chemical component of the Chinese traditional herb Cinnamomum cassia, is an effective cytotoxic agent against various human cancers. Our previous study indicated that CA could trigger apoptosis in three kinds of non-small cell lung cancer (NSCLC) cells. However, CA mechanism of action in NSCLC has not been unveiled completely. Herein, we showed that a novel circular RNA hsa_circ_0043256 was upregulated in NSCLC cells in response to CA treatment, as detected by microarray and real-time PCR. Hsa_circ_0043256 could inhibit cell proliferation and induce apoptosis, while hsa_circ_0043256 knock-down could promote cell proliferation and restrain apoptosis induced by CA. Bioinformatics analysis predicted that hsa_circ_0043256 could work as a miR-1252 sponge, which could in turn directly target a vital negative regulator of Canonical Wnt signaling, Itchy E3 ubiquitin protein ligase (ITCH), as validated by dual-luciferase assay. Western blot results further confirmed that hsa_circ_0043256 could upregulate ITCH expression, whereas miR-1252 could partially abolish this effect. Interestingly, hsa_circ_0043256 knock-down could weaken Wnt/ß-catenin pathway inhibition induced by CA. Finally, we discovered that CA induced apoptosis and meanwhile upregulated hsa_circ_0043256 expression in vivo. Immunohistochemical analysis revealed that ITCH expression was positively association with hsa_circ_0043256 levels. Above all, we characterized a new mechanism mediated by hsa_circ_0043256/miR-1252/ITCH axis in CA function against NSCLC, providing a novel insight into lung cancer therapy.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Apoptose/efeitos dos fármacos
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Neoplasias Pulmonares/tratamento farmacológico
RNA
[Mh] Termos MeSH secundário: Acroleína/farmacologia
Animais
Apoptose/genética
Carcinoma Pulmonar de Células não Pequenas/genética
Carcinoma Pulmonar de Células não Pequenas/patologia
Linhagem Celular Tumoral
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/patologia
Masculino
Camundongos Endogâmicos BALB C
MicroRNAs/genética
RNA/genética
Proteínas Repressoras/genética
Ubiquitina-Proteína Ligases/genética
Proteínas Wnt/efeitos dos fármacos
Proteínas Wnt/metabolismo
Ensaios Antitumorais Modelo de Xenoenxerto
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CTNNB1 protein, human); 0 (MIRN1254 microRNA, human); 0 (MicroRNAs); 0 (RNA, circular); 0 (Repressor Proteins); 0 (Wnt Proteins); 0 (beta Catenin); 63231-63-0 (RNA); 7864XYD3JJ (Acrolein); EC 2.3.2.26 (ITCH protein, human); EC 2.3.2.27 (Ubiquitin-Protein Ligases); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


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[PMID]:28950007
[Au] Autor:Ernstgård L; Dwivedi AM; Lundström JN; Johanson G
[Ad] Endereço:Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
[Ti] Título:Measures of odor and lateralization thresholds of acrolein, crotonaldehyde, and hexanal using a novel vapor delivery technique.
[So] Source:PLoS One;12(9):e0185479, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Humans are exposed to aldehydes in a variety of environmental situations. Aldehydes generally have a strong odor and are highly irritating to the mucous membranes. Knowledge about odor perception and especially irritation potency in humans is thus essential in risk assessment and regulation, e.g. setting occupational exposure limits. However, data on odor and irritation are lacking or limited for several aldehydes. The aim of the study was to determine the odor and lateralization thresholds of some commonly occurring aldehydes. Acrolein and crotonaldehyde where chosen as they are formed when organic material is heated or burned, e.g. during cigarette smoking. n-Hexanal was also included as it is emitted from wood pellets and fibreboard. MATERIAL AND METHODS: To study odor and lateralization thresholds of these aldehydes, a novel, inexpensive olfactometer was designed to enable delivery of reliable and stable test concentrations and thus valid measures of thresholds. The delivery system consists of seven syringe pumps, each connected to a Tedlar bag containing a predefined concentration of the tested aldehyde vapor. To validate the threshold measures, a test-retest was performed with a separate method, namely odor delivery via amber bottles. Twenty healthy naïve individuals were tested. RESULTS: The median odor thresholds of acrolein, crotonaldehyde and hexanal were 17, 0.8, and 97 ppb, respectively. No lateralization threshold could be identified for acrolein (highest tested concentration was 2 940 ppb in 5 subjects), whereas the medians were 3 and 390 ppb for the latter two. In addition, odor thresholds for n-hexanal were also determined using two methods where similar results were obtained, suggesting that the olfactometer presentation method is valid. CONCLUSION: We found olfactory detection and lateralization thresholds (except for acrolein) in alliance with, or lower than, previously reported in naïve subjects. The new olfactometer allows better control of presentations timing and vapor concentration.
[Mh] Termos MeSH primário: Acroleína
Aldeídos
Odorantes
Limiar Sensorial
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 7864XYD3JJ (Acrolein); 9DC2K31JJQ (n-hexanal); 9G72074TUW (2-butenal)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185479


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[PMID]:28886578
[Au] Autor:Kim JH
[Ad] Endereço:Division of Pharmacology, School of Korean Medicine, Pusan National University,50612, Republic of Korea. Electronic address: kmsct@pusan.ac.kr.
[Ti] Título:Extraction time and temperature affect the extraction efficiencies of coumarin and phenylpropanoids from Cinnamomum cassia bark using a microwave-assisted extraction method.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:196-203, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Microwave-assisted extraction (MAE), an efficient extraction tool, was employed to extract a coumarin and five phenylpropanoids (cinnamic acid, cinnamyl alcohol, cinnamaldehyde, 2-hydroxycinnamadehyde, and 2-methoxycinnamaldehyde) from Cinnamomum cassia bark using water as the extraction solvent. Six marker compounds were quantified by high-performance liquid chromatography-diode array detector using a validated analytical method. To investigate the influences of temperature and time on the extraction yields of the six marker compounds, the water extracts of C. cassia bark were prepared using a MAE method at six different extraction temperatures (70, 75, 80, 85, 90, and 95°C) and times (2, 4, 6, 8, 10, and 12min). Their influences were assessed by multiple regression analysis. The results obtained demonstrated that higher extraction temperature and longer extraction time positively affected coumarin and cinnamyl alcohol contents, but negatively affected extract contents of cinnamic acid, cinnamaldehyde and 2-hydroxycinnamaldehyde (all p-<0.05). The extraction of 2-methoxycinnamaldehyde was affected by both positively and negatively by increasing temperature and time. These changes during MAE were assumed by the chemical natures of the marker compounds with various functional groups. In conclusion, temperature and times significantly affected the extraction efficiencies of a coumarin and five phenylpropanoids from C. cassia bark when a water-based MAE method was used. This study provides a novel approach to the preparation of the water extract of C. cassia bark using MAE.
[Mh] Termos MeSH primário: Fracionamento Químico/métodos
Cinamatos
Cinnamomum aromaticum/química
Cumarínicos/isolamento & purificação
Casca de Planta/química
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Cromatografia Líquida de Alta Pressão/métodos
Cinamatos/análise
Cinamatos/química
Cinamatos/isolamento & purificação
Cumarínicos/análise
Cumarínicos/química
Modelos Lineares
Micro-Ondas
Extratos Vegetais/química
Propanóis
Análise de Regressão
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Coumarins); 0 (Plant Extracts); 0 (Propanols); 7864XYD3JJ (Acrolein); A4VZ22K1WT (coumarin); SR60A3XG0F (cinnamic aldehyde); SS8YOP444F (cinnamyl alcohol); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


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[PMID]:28780321
[Au] Autor:Sthijns MMJPE; den Hartog GJM; Scasso C; Haenen JP; Bast A; Haenen GRMM
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address: mireille.sthijns@maastrichtuniversity.nl.
[Ti] Título:Activation versus inhibition of microsomal glutathione S-transferase activity by acrolein. Dependence on the concentration and time of acrolein exposure.
[So] Source:Chem Biol Interact;275:116-120, 2017 Sep 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The toxicity of acrolein, an α,ß-unsaturated aldehyde, is due to its soft electrophilic nature and primarily involves the adduction of protein thiols. The thiol glutathione (GSH) forms the first line of defense against acrolein. The present study confirms that acrolein added to isolated rat liver microsomes can increase microsomal GSH transferase (MGST) activity 2-3 fold, which can be seen as a direct adaptive increase in the protection against acrolein. At a relatively high exposure level, acrolein appeared to inhibit MGST. The activation is due to adduction of thiol groups, and the inactivation probably involves adduction of amino groups in the enzyme by acrolein. The preference of acrolein to react with thiol groups over amino groups can explain why the enzyme is activated at a low exposure level and inhibited at a high exposure level of acrolein. These opposite forms of direct adaptation on the level of enzyme activity further narrow the thin line between survival and promotion of cell death, governed by the level of exposure.
[Mh] Termos MeSH primário: Acroleína/farmacologia
Glutationa Transferase/metabolismo
Microssomos Hepáticos/enzimologia
[Mh] Termos MeSH secundário: Acroleína/química
Acroleína/metabolismo
Animais
Ativação Enzimática/efeitos dos fármacos
Ativadores de Enzimas/farmacologia
Ensaios Enzimáticos
Inibidores Enzimáticos/farmacologia
Glutationa/química
Glutationa/metabolismo
Glutationa Transferase/química
Cinética
Masculino
Ninidrina/química
Ninidrina/metabolismo
Ratos
Ratos Wistar
Espectrofotometria Ultravioleta
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Activators); 0 (Enzyme Inhibitors); 7864XYD3JJ (Acrolein); EC 2.5.1.18 (Glutathione Transferase); GAN16C9B8O (Glutathione); HCL6S9K23A (Ninhydrin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


  6 / 2528 MEDLINE  
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[PMID]:28737916
[Au] Autor:Choi SK; Mun GI; Choi E; Kim SY; Kwon Y; Na Y; Lee YS
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Ewha Womans University , Seoul 120-750, Korea.
[Ti] Título:The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection.
[So] Source:J Nat Prod;80(8):2379-2383, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Células da Medula Óssea/citologia
Proteínas de Ligação a DNA/metabolismo
Propano/análogos & derivados
Propanóis/farmacologia
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Acroleína/química
Acroleína/farmacologia
Animais
Células da Medula Óssea/química
Proteínas de Ligação a DNA/química
Fatores de Transcrição de Choque Térmico
Camundongos
Estrutura Molecular
Propano/química
Propano/farmacologia
Propanóis/química
Fatores de Transcrição/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-hydroxy-3-methoxyphenylpropanal); 0 (4-hydroxy-3-methoxyphenylpropanol); 0 (DNA-Binding Proteins); 0 (Heat Shock Transcription Factors); 0 (Propanols); 0 (Transcription Factors); 06TPT01AD5 (coniferaldehyde); 7864XYD3JJ (Acrolein); T75W9911L6 (Propane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00126


  7 / 2528 MEDLINE  
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[PMID]:28719892
[Au] Autor:Zuo J; Zhao D; Yu N; Fang X; Mu Q; Ma Y; Mo F; Wu R; Ma R; Wang L; Zhu R; Liu H; Zhang D; Gao S
[Ad] Endereço:School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing, China.
[Ti] Título:Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue.
[So] Source:Cell Physiol Biochem;42(4):1514-1525, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) has been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed to investigate the potential anti-obesity effects of CA on mice fed a high-fat diet (HFD) and to explore the possible mechanisms involved. METHODS: Male C57BL/6J mice fed an HFD for 12 weeks were supplemented with CA (40 mg/kg/day) via gavage for an additional 8 weeks. Mice fed a standard diet were used as normal controls. RESULTS: The results revealed that CA treatment decreased body weight, fat mass, food intake, and serum lipid, free fatty acid and leptin levels. CA administration also improved insulin sensitivity in HFD-induced obese mice. Additionally, CA inhibited the hypertrophy of adipose tissue and induced browning of white adipose tissue. Uncoupling protein 1 (UCP1) was expressed in white adipose tissue after the oral administration of CA. Furthermore, CA enhanced the expression of the peroxisome proliferator-activated receptor γ (PPARγ), PR domain-containing 16 (PRDM16) and PPARγ coactivator 1α (PGC-1α) proteins in both brown and white adipose tissues. CONCLUSIONS: The results suggest that CA exhibits therapeutic potency against obesity by inducing the browning of white adipose tissue in HFD-fed mice.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Tecido Adiposo Marrom/efeitos dos fármacos
Tecido Adiposo Branco/efeitos dos fármacos
Fármacos Antiobesidade/farmacologia
Obesidade/tratamento farmacológico
[Mh] Termos MeSH secundário: Acroleína/farmacologia
Tecido Adiposo Marrom/metabolismo
Tecido Adiposo Branco/metabolismo
Administração Oral
Animais
Peso Corporal/efeitos dos fármacos
Proteínas de Ligação a DNA/genética
Proteínas de Ligação a DNA/metabolismo
Dieta Hiperlipídica/efeitos adversos
Ingestão de Alimentos/efeitos dos fármacos
Metabolismo Energético/efeitos dos fármacos
Ácidos Graxos não Esterificados/sangue
Regulação da Expressão Gênica
Resistência à Insulina
Leptina/genética
Leptina/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Obesidade/etiologia
Obesidade/genética
Obesidade/patologia
PPAR gama/genética
PPAR gama/metabolismo
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Proteína Desacopladora 1/genética
Proteína Desacopladora 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (DNA-Binding Proteins); 0 (Fatty Acids, Nonesterified); 0 (Leptin); 0 (PPAR gamma); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 0 (Ppargc1a protein, mouse); 0 (Prdm16 protein, mouse); 0 (Transcription Factors); 0 (Ucp1 protein, mouse); 0 (Uncoupling Protein 1); 7864XYD3JJ (Acrolein); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1159/000479268


  8 / 2528 MEDLINE  
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[PMID]:28686350
[Au] Autor:Lilic A; Wei T; Bennici S; Devaux JF; Dubois JL; Auroux A
[Ad] Endereço:IRCELYON, UMR 5256 CNRS- Université Lyon 1, 2 avenue Albert Einstein, 69626-, Villeurbanne cedex, France.
[Ti] Título:A Comparative Study of Basic, Amphoteric, and Acidic Catalysts in the Oxidative Coupling of Methanol and Ethanol for Acrolein Production.
[So] Source:ChemSusChem;10(17):3459-3472, 2017 Sep 11.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The impact of acid/base properties (determined by adsorption microcalorimetry) of various catalysts on the cross-aldolization of acetaldehyde and formaldehyde leading to acrolein was methodically studied in oxidizing conditions starting from a mixture of methanol and ethanol. The aldol condensation and further dehydration to acrolein were carried out on catalysts presenting various acid/base properties (MgO, Mg-Al oxides, Mg/SiO , NbP, and heteropolyanions on silica, HPA/SiO ). Thermodynamic calculations revealed that cross-aldolization is always favored compared with self-aldolization of acetaldehyde, which leads to crotonaldehyde formation. The presence of strong basic sites is shown to be necessary, but a too high amount drastically increases CO production. On strong acid sites, production of acrolein and carbon oxides (CO ) does not increase with temperature. The optimal catalyst for this process should be amphoteric with a balanced acid/base cooperation of medium strength sites and a small amount (<100 µmol g ) of very strong basic sites (Q >150 kJ mol ).
[Mh] Termos MeSH primário: Acroleína/química
Etanol/química
Metanol/química
Acoplamento Oxidativo
[Mh] Termos MeSH secundário: Adsorção
Catálise
Fenômenos Químicos
Concentração de Íons de Hidrogênio
Nitrogênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3K9958V90M (Ethanol); 7864XYD3JJ (Acrolein); N762921K75 (Nitrogen); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701040


  9 / 2528 MEDLINE  
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[PMID]:28621498
[Au] Autor:Hu Y; Li N; Li G; Wang A; Cong Y; Wang X; Zhang T
[Ad] Endereço:State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, PR China.
[Ti] Título:Sustainable Production of o-Xylene from Biomass-Derived Pinacol and Acrolein.
[So] Source:ChemSusChem;10(14):2880-2885, 2017 Jul 21.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:o-Xylene (OX) is a large-volume commodity chemical that is conventionally produced from fossil fuels. In this study, an efficient and sustainable two-step route is used to produce OX from biomass-derived pinacol and acrolein. In the first step, the phosphotungstic acid (HPW)-catalyzed pinacol dehydration in 1-ethyl-3-methylimidazolium chloride ([emim]Cl) selectively affords 2,3-dimethylbutadiene. The high selectivity of this reaction can be ascribed to the H-bonding interaction between Cl and the hydroxy group of pinacol. The stabilization of the carbocation intermediate by the surrounding anion Cl may be another reason for the high selectivity. Notably, the good reusability of the HPW/[emim]Cl system can reduce the waste output and production cost. In the second step, OX is selectively produced by a Diels-Alder reaction of 2,3-dimethylbutadiene and acrolein, followed by a Pd/C-catalyzed decarbonylation/aromatization cascade in a one-pot fashion. The sustainable two-step process efficiently produces renewable OX in 79 % overall yield. Analogously, biomass-derived crotonaldehyde and pinacol can also serve as the feedstocks for the production of 1,2,4-trimethylbenzene.
[Mh] Termos MeSH primário: Acroleína/química
Biomassa
Glicóis/química
Química Verde
Xilenos/química
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycols); 0 (Xylenes); 0 (pinacol); 7864XYD3JJ (Acrolein); Z2474E14QP (2-xylene)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700823


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[PMID]:28525761
[Au] Autor:Mateo EM; Gómez JV; Domínguez I; Gimeno-Adelantado JV; Mateo-Castro R; Gavara R; Jiménez M
[Ad] Endereço:Department of Microbiology and Ecology, University of Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain.
[Ti] Título:Impact of bioactive packaging systems based on EVOH films and essential oils in the control of aflatoxigenic fungi and aflatoxin production in maize.
[So] Source:Int J Food Microbiol;254:36-46, 2017 Aug 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Aspergillus flavus and A. parasiticus are the most common fungal species associated with aflatoxin (AF) contamination of cereals, especially maize, and other agricultural commodities. AFB the most frequent and toxic metabolite, is a powerful hepatotoxic, teratogenic and mutagenic compound. Effective strategies to control these fungal species and AFs in food and feed are required. Active packaging film containing essential oils (EO) is one of the most innovative food packaging concepts. In this study, ethylene-vinyl alcohol (EVOH) copolymer films incorporating EO from Origanum vulgare (ORE), Cinnamomum zeylanicum (CIN) or their major active constituents, carvacrol (CAR) and cinnamaldehyde (CINHO), respectively, were developed and assayed to control growth of A. flavus and A. parasiticus and AF production in maize grains under different a and temperature regimens. EO doses assayed in cultures were in the range 0.25-4.0mg/Petri dish. The factors a , temperature, type of EVOH-EO film and fungal species significantly influenced the ED values of all assayed films. Growth rate (GR) of both species was usually higher at 0.99 than at 0.96 a and at 37°C than at 25°C. However, the contrary was found with regard to AF production. The order of efficacy of EVOH-EO films to control growth of both species and AF production was EVOH-CINHO>EVOH-CAR>EVOH-ORE>EVOH-CIN. The effective dose (ED ) (mg EO/plate) for EVOH-CINHO and EVOH-CIN films against A. flavus were in the ranges of 0.125 and 2.475-3.500 and against A. parasiticus in the ranges of 0.121-0.133 and 2.275-3.625, respectively. Under the assayed conditions, the ED for EVOH-CINHO film were 0.22-0.23mg/plate for both species. It was the most effective bioactive film to control fungal growth (vapour phase) and AF production, regardless of a and temperature. This is the first study about the impact that interacting environmental conditions and bioactive EVOH-CINHO, EVOH-ORE, EVOH-CIN EVOH-CAR films have on the growth of aflatoxigenic fungi and on AF production in maize grains.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Antifúngicos/farmacologia
Aspergillus flavus/crescimento & desenvolvimento
Monoterpenos/farmacologia
Óleos Voláteis/farmacologia
Polivinil/farmacologia
Zea mays/microbiologia
[Mh] Termos MeSH secundário: Acroleína/farmacologia
Aflatoxinas/biossíntese
Cinnamomum zeylanicum/metabolismo
Microbiologia de Alimentos/métodos
Embalagem de Alimentos
Origanum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Antifungal Agents); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Polyvinyls); 25067-34-9 (ethylene-vinyl alcohol copolymer); 7864XYD3JJ (Acrolein); 9B1J4V995Q (carvacrol); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE



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