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Pesquisa : D02.047.222 [Categoria DeCS]
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[PMID]:28744886
[Au] Autor:Zhao A; Zhang L; Li R; Shang J; Yi H; Wang Y; Zhang D; Wang S; Fang M
[Ad] Endereço:Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, China.
[Ti] Título:Development and validation of an LC-MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription.
[So] Source:Biomed Chromatogr;32(2), 2018 Feb.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A sensitive, specific and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of seven constituents of the Zaoren Anshen prescription (ZAP) in rat plasma after oral administration of the ZAP: spinosin, salvianic acid A, 6'''-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin. The plasma samples and the internal standard (IS) sulfamethoxazole were extracted using acetonitrile. Chromatographic separation was performed with an Agilent HC-C column using a gradient elution profile and a mobile phase consisting of 0.01% formic acid in water (A) and acetonitrile (B). The analytes were quantified simultaneously in a single run using an ion trap mass spectrometer operated in the multiple reaction monitoring mode and electrospray ion-source polarity in the positive and negative modes. The calibration curves for spinosin, salvianic acid A, 6'''-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin were linear over the concentration ranges of 2.90-1160, 2.50-1000, 1.80-720, 0.65-260, 2.50-1000, 8.00-1600 and 1.30-520 ng/mL, respectively. The intra- and inter-day precisions in terms of relative standard deviation were <18.9%, and the accuracies in terms of relative error were within ±14.2%. Consequently, the proposed method was successfully applied to the pharmacokinetic analysis of these seven major active compounds in rats administered ZAP. These results will facilitate research aiming to predict the effectiveness of the optimal dose of ZAP and might be beneficial for the therapeutic use of ZAP in the clinical setting.
[Mh] Termos MeSH primário: Benzaldeídos/sangue
Benzofuranos/sangue
Catecóis/sangue
Ciclo-Octanos/sangue
Medicamentos de Ervas Chinesas/farmacocinética
Flavonoides/sangue
Lignanas/sangue
Compostos Policíclicos/sangue
[Mh] Termos MeSH secundário: Animais
Benzaldeídos/química
Benzaldeídos/farmacocinética
Benzofuranos/química
Benzofuranos/farmacocinética
Catecóis/química
Catecóis/farmacocinética
Cromatografia Líquida/métodos
Ciclo-Octanos/química
Ciclo-Octanos/farmacocinética
Estabilidade de Medicamentos
Medicamentos de Ervas Chinesas/análise
Medicamentos de Ervas Chinesas/química
Flavonoides/química
Flavonoides/farmacocinética
Lignanas/química
Lignanas/farmacocinética
Limite de Detecção
Modelos Lineares
Masculino
Compostos Policíclicos/química
Compostos Policíclicos/farmacocinética
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Benzofurans); 0 (Catechols); 0 (Cyclooctanes); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Lignans); 0 (Polycyclic Compounds); 4PVP2HCH4T (protocatechualdehyde); 72063-39-9 (spinosin); C1GQ844199 (salvianolic acid B); G01BQC0879 (schizandrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.4055


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[PMID]:29198904
[Au] Autor:Fatima N; Reddy BVS; Gowravaram S; Yadav JS; Kadari S; Putta CS
[Ad] Endereço:Center for Semiochemicals Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: dr.narjisiict@yahoo.com.
[Ti] Título:Synthesis and biological evaluation of 1-amino isochromans from 2-bromoethyl benzaldehyde and amines in acid medium.
[So] Source:Bioorg Med Chem Lett;28(2):196-201, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have developed a facile and efficient synthetic route to substituted isochromans for the first time by reacting 2-(2-bromoethyl)benzaldehyde with a variety of aryl, heteroaryl amines in AcOH. The reaction is catalyst/additive free and takes place at reflux conditions with short reaction time to furnish products in good to excellent yields. All the compounds have been characterized by spectral techniques such as IR, H NMR and Mass etc. Synthesized compounds were evaluated for antimicrobial activity against specific bacterial like 1) Staphylococcus strains aureus 2) Bacillus subtilis 3) Escherichia coli 4) Pseudomonas aeruginosa. Compounds 3e, 3n, 3 m, 3 l, 3 k, 3j and 3b showed most potent in vitro activity against bacterial strains.
[Mh] Termos MeSH primário: Ácido Acético/química
Aminas/química
Antibacterianos/farmacologia
Benzaldeídos/química
Cromanos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Bacillus subtilis/efeitos dos fármacos
Benzaldeídos/síntese química
Cromanos/síntese química
Cromanos/química
Relação Dose-Resposta a Droga
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amines); 0 (Anti-Bacterial Agents); 0 (Benzaldehydes); 0 (Chromans); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:29220795
[Au] Autor:Scipioni M; Kay G; Megson I; Kong Thoo Lin P
[Ad] Endereço:School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK.
[Ti] Título:Novel vanillin derivatives: Synthesis, anti-oxidant, DNA and cellular protection properties.
[So] Source:Eur J Med Chem;143:745-754, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Antioxidants have been the subject of intense research interest mainly due to their beneficial properties associated with human health and wellbeing. Phenolic molecules, such as naturally occurring Resveratrol and Vanillin, are well known for their anti-oxidant properties, providing a starting point for the development of new antioxidants. Here we report, for the first time, the synthesis of a number of new vanillin through the reductive amination reaction between vanillin and a selection of amines. All the compounds synthesised, exhibited strong antioxidant properties in DPPH, FRAP and ORAC assays, with compounds 1b and 2c being the most active. The latter also demonstrated the ability to protect plasmid DNA from oxidative damage in the presence of the radical initiator AAPH. At cellular level, neuroblastoma SH-SY5Y cells were protected from oxidative damage (H O , 400 µM) with both 1b and 2c. The presence of a tertiary amino group, along with the number of vanillin moieties in the molecule contribute for the antioxidant activity. Furthermore, the delocalization of the electron pair of the nitrogen and the presence of an electron donating substituent to enhance the antioxidant properties of this new class of compounds. In our opinion, vanillin derivatives 1b and 2c described in this work can provide a viable platform for the development of antioxidant based therapeutics.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Benzaldeídos/farmacologia
DNA/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antioxidantes/síntese química
Antioxidantes/química
Benzaldeídos/síntese química
Benzaldeídos/química
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Dano ao DNA
Relação Dose-Resposta a Droga
Seres Humanos
Estrutura Molecular
Estresse Oxidativo/efeitos dos fármacos
Plasmídeos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzaldehydes); 9007-49-2 (DNA); CHI530446X (vanillin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:28460278
[Au] Autor:Kamireddy K; Matam P; P S P; Parvatam G
[Ad] Endereço:Academy of Scientific and Innovative Research (CSIR-CFTRI campus, Mysore), India; Plant Cell Biotechnology Department, CSIR-CFTRI, Mysore-570020, India.
[Ti] Título:Biochemical characterization of a key step involved in 2H4MB production in Decalepis hamiltonii.
[So] Source:J Plant Physiol;214:74-80, 2017 Jul.
[Is] ISSN:1618-1328
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Decalepis hamiltonii is widely known for its flavour molecule 2-Hydroxy-4-Methoxy Benzaldehyde (2H4MB), a structural isomer of vanillin. As the biosynthetic pathway of 2H4MB is not known, we hypothesised 2H4MB origins could be from phenylpropanoid pathway (PPP). Accordingly, a study was conducted using PPP inhibitors (viz. piperonylic acid, MDCA and propanil) against in vitro root cultures of D. hamiltonii to find the branch of PPP which catalyses the 2H4MB formation. HPLC analysis was carried out to quantify 2H4MB levels in control and respective inhibitor treated root cultures in vitro. The results obtained revealed that piperonylic acid did not inhibit 2H4MB biosynthesis in the given period, whereas MDCA and propanil had the marked inhibitory effect. The inhibitory effect was evident with 13.2, 33.6 and 37.9% decrease in 2H4MB levels at 50, 100 and 150mM concentration of MDCA respectively in comparison with control roots. Similarly, the inhibitory effect of propanil on 2H4MB biosynthesis was obvious with 23.7, 49.5 and 57.9% decrease in 2H4MB levels at 50, 100 and 150µM concentration of inhibitor respectively when compared with control roots. Propanil showed a greater slow down effect on 2H4MB biosynthesis compared to MDCA. Incorporation of 0.1, 0.5 and 1.0mM ferulic acid as a precursor to in vitro root cultures of D. hamiltonii showed an increase in 2H4MB levels at the rate of 3.1, 107 and 94.1% respectively as quantified by HPLC analysis. However, ferulic acid in conjunction with propanil did not show any increase in 2H4MB levels. This clearly explains that ferulic acid is channelled through the 4-CL (4-coumarate CoA ligase) enzyme, where it would be converted to feruloyl-CoA and could be further converted to 2H4MB in D. hamiltonii.
[Mh] Termos MeSH primário: Apocynaceae/metabolismo
Extratos Vegetais/metabolismo
[Mh] Termos MeSH secundário: Benzaldeídos/metabolismo
Benzoatos/metabolismo
Ácidos Cumáricos/metabolismo
Fenilpropionatos/metabolismo
Raízes de Plantas/metabolismo
Propanil/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Benzoates); 0 (Coumaric Acids); 0 (Phenylpropionates); 0 (Plant Extracts); 0 (phenylpropanoid 3,4-(methylenedioxy)cinnamic acid); 709-98-8 (Propanil); AVM951ZWST (ferulic acid); QX3V1NO0KH (piperonylic acid); TA269SD04T (benzaldehyde)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28923486
[Au] Autor:Nikaido M; Acedo JN; Hatta K; Piotrowski T
[Ad] Endereço:Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Graduate School of Life Sciences, University of Hyogo, Hyogo Pref. 678-1297, Japan.
[Ti] Título:Retinoic acid is required and Fgf, Wnt, and Bmp signaling inhibit posterior lateral line placode induction in zebrafish.
[So] Source:Dev Biol;431(2):215-225, 2017 11 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The lateral line system is a mechanosensory systems present in aquatic animals. The anterior and posterior lateral lines develop from anterior and posterior lateral line placodes (aLLp and pLLp), respectively. Although signaling molecules required for the induction of other cranial placodes have been well studied, the molecular mechanisms underlying formation of the lateral line placodes are unknown. In this study we tested the requirement of multiple signaling pathways, such as Wnt, Bmp Fgf, and Retinoic Acid for aLLp and pLLp induction. We determined that aLLp specification requires Fgf signaling, whilst pLLp specification requires retinoic acid which inhibits Fgf signaling. pLLp induction is also independent of Wnt and Bmp activities, even though these pathways limit the boundaries of the pLLp. This is the first report that the aLLp and pLLp depend on different inductive mechanisms and that pLLp induction requires the inhibition of Fgf, Wnt and Bmp signaling.
[Mh] Termos MeSH primário: Proteínas Morfogenéticas Ósseas/metabolismo
Fatores de Crescimento de Fibroblastos/metabolismo
Sistema da Linha Lateral/embriologia
Transdução de Sinais
Tretinoína/farmacologia
Proteínas Wnt/metabolismo
Peixe-Zebra/embriologia
Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Benzaldeídos/farmacologia
Padronização Corporal/efeitos dos fármacos
Padronização Corporal/genética
Gastrulação/efeitos dos fármacos
Sistema da Linha Lateral/efeitos dos fármacos
Sistema da Linha Lateral/metabolismo
Transdução de Sinais/efeitos dos fármacos
Proteínas de Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Bone Morphogenetic Proteins); 0 (Wnt Proteins); 0 (Zebrafish Proteins); 5688UTC01R (Tretinoin); 62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:28881295
[Au] Autor:Song L; Gao D; Li S; Wang Y; Liu H; Jiang Y
[Ad] Endereço:Department of Chemistry, Tsinghua University, Beijing 100084, China; State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.
[Ti] Título:Simultaneous quantitation of hydrazine and acetylhydrazine in human plasma by high performance liquid chromatography-tandem mass spectrometry after derivatization with p-tolualdehyde.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:189-195, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed for simultaneous quantitative analysis of hydrazine and acetylhydrazine in human plasma based on the strategy of p-tolualdehyde derivatization. The derivatization reactions were easily realized by ultrasonic manipulation for 40min. Good separation of the derivatization products was achieved using a C column by gradient elution. The optimized mass transition ion-pairs (m/z) monitored for the two hydrazine derivatives were m/z 237.1≫>119.9 and m/z 176.9≫>117.8, respectively. The limit of detection (LOD) and limit of quantification (LOQ) for hydrazine were 0.002 and 0.005ngmL separately. And they were 0.03 and 0.05ngmL for acetylhydrazine, respectively. The linear range was 0.005-50ngmL for hydrazine and 0.05-500ngmL for acetylhydrazine with R greater than 0.999. The recovery range was determined to be 95.38-108.12% with the relative standard deviation (RSD) in the range of 1.24-14.89%. The method was successfully applied to detect 30 clinical plasma samples of pulmonary tuberculosis patients treated with isoniazid. The concentrations were from 0.04-1.99ngmL for hydrazine and 0.06-142.43ngmL for acetylhydrazine. The results indicated that our developed method had the potential for the detection of hydrazine toxicology in complex biological samples. Furthermore, the method has an important significance to clinical treatment with drugs.
[Mh] Termos MeSH primário: Benzaldeídos/química
Cromatografia Líquida de Alta Pressão/métodos
Hidrazinas/sangue
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Antituberculosos/uso terapêutico
Seres Humanos
Hidrazinas/química
Isoniazida/uso terapêutico
Modelos Lineares
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Tuberculose Pulmonar/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents); 0 (Benzaldehydes); 0 (Hydrazines); 104-87-0 (4-methylbenzaldehyde); 27RFH0GB4R (hydrazine); SK0DPC9098 (acetylhydrazine); V83O1VOZ8L (Isoniazid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE


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[PMID]:28869767
[Au] Autor:Elegheert J; Brigé A; Van Beeumen J; Savvides SN
[Ad] Endereço:Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Department of Biochemistry and Microbiology, Ghent University, Belgium.
[Ti] Título:Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands.
[So] Source:FEBS Lett;591(20):3391-3401, 2017 Oct.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Shewanella oneidensis, a Gram-negative γ-proteobacterium with an extensive redox capacity, possesses four old yellow enzyme (OYE) homologs. Of these, Shewanella yellow enzyme 4 (SYE4) is implicated in resistance to oxidative stress. Here, we present a series of high-resolution crystal structures for SYE4 in the oxidized and reduced states, and in complex with phenolic ligands and the nitro-aromatic explosive picric acid. The structures unmask new features, including the identification of a binding platform for long-chain hydrophobic molecules. Furthermore, we present the first structural observation of a hydride-Meisenheimer complex of picric acid with a flavoenzyme. Overall, our study exposes the binding promiscuity of SYE4 toward a variety of electrophilic substrates and is consistent with a general detoxification function for SYE4.
[Mh] Termos MeSH primário: Anisóis/química
Proteínas de Bactérias/química
Benzaldeídos/química
Cresóis/química
NADPH Desidrogenase/química
Shewanella/química
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Anisóis/metabolismo
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Benzaldeídos/metabolismo
Sítios de Ligação
Clonagem Molecular
Cresóis/metabolismo
Cristalografia por Raios X
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Interações Hidrofóbicas e Hidrofílicas
Isoenzimas/química
Isoenzimas/genética
Isoenzimas/metabolismo
Cinética
Ligantes
Modelos Moleculares
NADPH Desidrogenase/genética
NADPH Desidrogenase/metabolismo
Oxirredução
Estresse Oxidativo
Picratos/química
Picratos/metabolismo
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Estrutura Secundária de Proteína
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Shewanella/enzimologia
Especificidade por Substrato
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Anisoles); 0 (Bacterial Proteins); 0 (Benzaldehydes); 0 (Cresols); 0 (Isoenzymes); 0 (Ligands); 0 (Picrates); 0 (Recombinant Proteins); 6HT8U7K3AM (mequinol); A49OS0F91S (picric acid); EC 1.6.99.1 (NADPH Dehydrogenase); GF3CGH8D7Z (cresol); O1738X3Y38 (4-hydroxybenzaldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12833


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[PMID]:28867710
[Au] Autor:Suthar SK; Bansal S; Narkhede N; Guleria M; Alex AT; Joseph A
[Ad] Endereço:Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences.
[Ti] Título:Design, Synthesis and Biological Evaluation of Oxindole-Based Chalcones as Small-Molecule Inhibitors of Melanogenic Tyrosinase.
[So] Source:Chem Pharm Bull (Tokyo);65(9):833-839, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The enzyme tyrosinase regulates melanogenesis and skin hyperpigmentation by converting L-3,4-dihydroxyphenylalanine (L-DOPA) into dopaquinone, a key step in the melanin biosynthesis. The present work deals with design and synthesis of various oxindole-based chalcones as monophenolase and diphenolase activity inhibitors of tyrosinase. Among the screened compounds, 4-hydroxy-3-methoxybenzylidene moiety bearing chalcone (7) prepared by one pot reaction of oxindole and vanillin displayed the highest activity against tyrosinase with IC s of 63.37 and 59.71 µM in monophenolase and diphenolase activity assays, respectively. In molecular docking studies, chalcone 7 also showed the highest binding affinity towards the enzyme tyrosinase while exhibiting the lowest estimated free energy of binding, among all the ligands docked.
[Mh] Termos MeSH primário: Chalconas/química
Desenho de Drogas
Inibidores Enzimáticos/síntese química
Monofenol Mono-Oxigenase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Benzaldeídos/química
Sítios de Ligação
Domínio Catalítico
Chalconas/síntese química
Chalconas/metabolismo
Inibidores Enzimáticos/química
Inibidores Enzimáticos/metabolismo
Indóis/química
Concentração Inibidora 50
Melaninas/metabolismo
Simulação de Acoplamento Molecular
Monofenol Mono-Oxigenase/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Chalcones); 0 (Enzyme Inhibitors); 0 (Indoles); 0 (Melanins); 0S9338U62H (2-oxindole); CHI530446X (vanillin); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00301


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[PMID]:28797349
[Au] Autor:Lindholm D; Lindbäck J; Armstrong PW; Budaj A; Cannon CP; Granger CB; Hagström E; Held C; Koenig W; Östlund O; Stewart RAH; Soffer J; White HD; de Winter RJ; Steg PG; Siegbahn A; Kleber ME; Dressel A; Grammer TB; März W; Wallentin L
[Ad] Endereço:Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. Electronic address: daniel.lindholm@ucr.uu.se.
[Ti] Título:Biomarker-Based Risk Model to Predict Cardiovascular Mortality in Patients With Stable Coronary Disease.
[So] Source:J Am Coll Cardiol;70(7):813-826, 2017 Aug 15.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Currently, there is no generally accepted model to predict outcomes in stable coronary heart disease (CHD). OBJECTIVES: This study evaluated and compared the prognostic value of biomarkers and clinical variables to develop a biomarker-based prediction model in patients with stable CHD. METHODS: In a prospective, randomized trial cohort of 13,164 patients with stable CHD, we analyzed several candidate biomarkers and clinical variables and used multivariable Cox regression to develop a clinical prediction model based on the most important markers. The primary outcome was cardiovascular (CV) death, but model performance was also explored for other key outcomes. It was internally bootstrap validated, and externally validated in 1,547 patients in another study. RESULTS: During a median follow-up of 3.7 years, there were 591 cases of CV death. The 3 most important biomarkers were N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), and low-density lipoprotein cholesterol, where NT-proBNP and hs-cTnT had greater prognostic value than any other biomarker or clinical variable. The final prediction model included age (A), biomarkers (B) (NT-proBNP, hs-cTnT, and low-density lipoprotein cholesterol), and clinical variables (C) (smoking, diabetes mellitus, and peripheral arterial disease). This "ABC-CHD" model had high discriminatory ability for CV death (c-index 0.81 in derivation cohort, 0.78 in validation cohort), with adequate calibration in both cohorts. CONCLUSIONS: This model provided a robust tool for the prediction of CV death in patients with stable CHD. As it is based on a small number of readily available biomarkers and clinical factors, it can be widely employed to complement clinical assessment and guide management based on CV risk. (The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial [STABILITY]; NCT00799903).
[Mh] Termos MeSH primário: Benzaldeídos/uso terapêutico
Doença das Coronárias/mortalidade
Peptídeo Natriurético Encefálico/sangue
Oximas/uso terapêutico
Fragmentos de Peptídeos/sangue
Medição de Risco/métodos
Troponina T/sangue
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/sangue
Doença das Coronárias/sangue
Doença das Coronárias/prevenção & controle
Feminino
Seguimentos
Saúde Global
Seres Humanos
Masculino
Meia-Idade
Inibidores de Fosfolipase A2/uso terapêutico
Prognóstico
Estudos Prospectivos
Fatores de Risco
Prevenção Secundária/métodos
Taxa de Sobrevida/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Biomarkers); 0 (Oximes); 0 (Peptide Fragments); 0 (Phospholipase A2 Inhibitors); 0 (Troponin T); 0 (pro-brain natriuretic peptide (1-76)); 114471-18-0 (Natriuretic Peptide, Brain); UI1U1MYH09 (darapladib)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


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[PMID]:28767917
[Au] Autor:Peretti AL; Antunes JS; Lovison K; Kunz RI; Castor LRG; Brancalhão RMC; Bertolini GRF; Ribeiro LFC
[Ad] Endereço:Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brazil.
[Ti] Título:Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury.
[So] Source:Einstein (Sao Paulo);15(2):186-191, 2017 Apr-Jun.
[Is] ISSN:2317-6385
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:Objective: To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods: Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by compression of the sciatic nerve; the Vanillin Group and Injury + Vanillin Group, were treated daily with oral doses of vanillin (150mg/kg) from the 3rd to the 21st day after induction of nerve injury. At the end of the experiment, the tibialis anterior and soleus muscles were dissected and processed for light microscopy and submitted to morphological analysis. Results: The nerve compression promoted morphological changes, typical of denervation, and the treatment with vanillin was responsible for different responses in the studied muscles. For the tibialis anterior, there was an increase in the number of satellite cells, central nuclei and fiber atrophy, as well as fascicular disorganization. In the soleus, only increased vascularization was observed, with no exacerbation of the morphological alterations in the fibers. Conclusion: The treatment with vanillin promoted increase in intramuscular vascularization for the muscles studied, with pro-inflammatory potential for tibialis anterior, but not for soleus muscle. Objetivo: Avaliar a ação da vanilina (Vanilla planifolia) sobre a morfologia dos músculos tibial anterior e sóleo após lesão nervosa periférica. Métodos: Ratos Wistar foram divididos em quatro grupos, com sete animais cada, sendo Grupo Controle, Grupo Vanilina, Grupo Lesão e Grupo Lesão + Vanilina. Os animais dos Grupos Lesão e Grupo Lesão + Vanilina foram submetidos à lesão nervosa por meio da compressão do nervo isquiático, e os Grupos Vanilina e Grupo Lesão + Vanilina foram tratados diariamente com doses orais de vanilina (150mg/kg) do 3o ao 21o dia após a indução da lesão nervosa. Ao término do experimento, os músculos tibial anterior e sóleo foram dissecados e seguiram o processamento de rotina em microscopia de luz, para posterior análise morfológica. Resultados: A compressão nervosa promoveu alterações morfológicas características de denervação, sendo que o tratamento com vanilina foi responsável por respostas distintas nos músculos estudados. Para o tibial anterior, houve aumento do número de células satélites, núcleos centrais e atrofia das fibras, bem como desorganização fascicular. Já no sóleo, houve apenas aumento da vascularização, sem exacerbação das alterações morfológicas nas fibras. Conclusão: O tratamento com vanilina promoveu o aumento da vascularização intramuscular para os músculos estudados, com potencial pró-inflamatório para o tibial anterior, o que não ocorreu no músculo sóleo.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Benzaldeídos/farmacologia
Tecido Conjuntivo/efeitos dos fármacos
Músculo Esquelético/efeitos dos fármacos
Neuropatia Ciática/patologia
[Mh] Termos MeSH secundário: Animais
Tecido Conjuntivo/patologia
Seres Humanos
Masculino
Modelos Animais
Fibras Musculares Esqueléticas/efeitos dos fármacos
Músculo Esquelético/patologia
Distribuição Aleatória
Ratos Wistar
Neuropatia Ciática/reabilitação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzaldehydes); CHI530446X (vanillin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE



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