Base de dados : MEDLINE
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[PMID]:28285876
[Au] Autor:Gup R; Erer O; Dilek N
[Ad] Endereço:Department of Chemistry, Mugla Sitki Koçman University, 48100 Mugla, Turkey. Electronic address: rgup@mu.edu.tr.
[Ti] Título:One-pot synthesis of a new 2-substituted 1,2,3-triazole 1-oxide derivative from dipyridyl ketone and isonitrosoacetophenone hydrazone: Nickel(II) complex, DNA binding and cleavage properties.
[So] Source:Bioorg Chem;71:325-334, 2017 Apr.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An efficient and simple one-pot synthesis of a new 1,2,3-triazole-1-oxide via reaction between isonitrosoacetophenone hydrazone and dipyridyl ketone in the EtOH/AcOH at room temperature has been developed smoothly in high yield. The reaction proceeds via metal salt free, in-situ formation of asymmetric azine followed by cyclization to provide 1,2,3-triazole 1-oxide compound. It has been structurally characterized. The 1:1 ratio reaction of the 1,2,3-triazole 1-oxide ligand with nickel(II) chloride gives the mononuclear complex [Ni(L)(DMF)Cl ], hexa-coordinated within an octahedral geometry. Characterization of the 1,2,3-triazole compound and its Ni(II) complex with FTIR, H and C NMR, UV-vis and elemental analysis also confirms the proposed structures of the compounds. The interactions of the compounds with Calf thymus DNA (CT-DNA) have been investigated by UV-visible spectra and viscosity measurements. The results suggested that both ligand and Ni(II) complex bind to DNA in electrostatic interaction and/or groove binding, also with a slight partial intercalation in the case of ligand. DNA cleavage experiments have been also investigated by agarose gel electrophoresis in the presence and absence of an oxidative agent (H O ). Both 1,2,3-triazole 1-oxide ligand and its nickel(II) complex show nuclease activity in the presence of hydrogen peroxide. DNA binding and cleavage affinities of the 1,2,3-triazole 1-oxide ligand is stronger than that of the Ni(II) complex.
[Mh] Termos MeSH primário: Complexos de Coordenação/química
Complexos de Coordenação/farmacologia
Clivagem do DNA/efeitos dos fármacos
Níquel/química
Níquel/farmacologia
Triazóis/química
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Técnicas de Química Combinatória/métodos
Complexos de Coordenação/síntese química
Cristalografia por Raios X
DNA/metabolismo
Hidrazonas/química
Modelos Moleculares
Fenilglioxal/análogos & derivados
Fenilglioxal/química
Triazóis/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Hydrazones); 0 (Triazoles); 532-54-7 (isonitrosoacetophenone); 7OV03QG267 (Nickel); 9007-49-2 (DNA); 91080-16-9 (calf thymus DNA); N45G3015PA (Phenylglyoxal)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:27787914
[Au] Autor:Guo H; Feng X; Hong C; Chen H; Zeng F; Zheng B; Jiang D
[Ad] Endereço:State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
[Ti] Título:Malate secretion from the root system is an important reason for higher resistance of Miscanthus sacchariflorus to cadmium.
[So] Source:Physiol Plant;159(3):340-353, 2017 Mar.
[Is] ISSN:1399-3054
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Miscanthus is a vigorous perennial Gramineae genus grown throughout the world as a promising bioenergy crop and generally regarded as heavy metal tolerant due to its ability to absorb heavy metals. However, little is known about the mechanism for heavy metal tolerance in Miscanthus. In this study, two Miscanthus species (Miscanthus sacchariflorus and Miscanthus floridulus) exhibiting different cadmium (Cd) sensitivity were used to address the mechanisms of Cd tolerance. Under the same Cd stress, M. sacchariflorus showed higher Cd tolerance with better growth and lower Cd accumulation in both shoots and roots than M. floridulus. The malate (MA) content significantly increased in root exudates of M. sacchariflorus following Cd treatment while it was almost unchanged in M. floridulus. Cellular Cd analysis and flux data showed that exogenous MA application markedly restricted Cd influx and accumulation while an anion-channel inhibitor (phenylglyoxal) effectively blocked Cd-induced MA secretion and increased Cd influx in M. sacchariflorus, indicating that MA secretion could alleviate Cd toxicity by reducing Cd uptake. The genes of malate dehydrogenases (MsMDHs) and Al-activated malate transporter 1 (MsALMT1) in M. sacchariflorus were highly upregulated under Cd stress, compared with that in M. floridulus. The results indicate that Cd-induced MA synthesis and secretion efficiently alleviate Cd toxicity by reducing Cd influx in M. sacchariflorus.
[Mh] Termos MeSH primário: Cádmio/toxicidade
Malatos/metabolismo
Poaceae/fisiologia
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Proteínas de Transporte de Ânions/antagonistas & inibidores
Proteínas de Transporte de Ânions/genética
Proteínas de Transporte de Ânions/metabolismo
Cádmio/metabolismo
Malato Desidrogenase/genética
Malato Desidrogenase/metabolismo
Malatos/farmacologia
Fenilglioxal/farmacologia
Proteínas de Plantas/antagonistas & inibidores
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Raízes de Plantas/citologia
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/genética
Raízes de Plantas/fisiologia
Poaceae/citologia
Poaceae/efeitos dos fármacos
Poaceae/genética
Poluentes do Solo/metabolismo
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anion Transport Proteins); 0 (Malates); 0 (Plant Proteins); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); EC 1.1.1.37 (Malate Dehydrogenase); N45G3015PA (Phenylglyoxal)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1111/ppl.12526


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[PMID]:27725279
[Au] Autor:Gull P; Dar OA; Malik MA; Hashmi AA
[Ad] Endereço:Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, India.
[Ti] Título:Design, synthesis, characterization and antimicrobial/antioxidant activities of 1, 4-dicarbonyl-phenyl-dihydrazide based macrocyclic ligand and its Cu(II), Co(II) and Ni(II) complexes.
[So] Source:Microb Pathog;100:237-243, 2016 Nov.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mononuclear transition metal complexes of Cu(II), Co(II) and Ni(II) with a newly synthesised macrocyclic ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and 1,2-diphenylethane-1,2-dione (2:2) have been synthesised. The synthesised compounds were characterised by various physical and spectroscopic techniques including elemental analysis, FTIR, Uv-Vis., H NMR, mass spectra, magnetic moment and XRD. The investigation of these macrocyclic complexes established that the stability of metal-ligand coordination through N atoms as tetradentate chelates. The metal/ligands ratio of 1:1 was proposed to afford octahedral geometry for the complexes. The antimicrobial activity of the compounds against some bacterial and fungal species were done by well diffusion method and the results shows that the metal complexes have a promising biological activity comparable with the parent ligand against all bacterial and fungal species. The antioxidant activity of the compounds was also studied through scavenging effect on DPPH radicals with the copper complex showing enhanced activity than other compounds. Additionally, the docking studies predicted the high antimicrobial activity due to the interaction of ligand with the protein.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Complexos de Coordenação/farmacologia
Hidrazinas/farmacologia
Compostos Macrocíclicos/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/síntese química
Antioxidantes/síntese química
Bactérias/efeitos dos fármacos
Complexos de Coordenação/síntese química
Depuradores de Radicais Livres/metabolismo
Fungos/efeitos dos fármacos
Hidrazinas/síntese química
Compostos Macrocíclicos/síntese química
Testes de Sensibilidade Microbiana
Fenilglioxal/análogos & derivados
Análise Espectral
Elementos de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Coordination Complexes); 0 (Free Radical Scavengers); 0 (Hydrazines); 0 (Macrocyclic Compounds); 0 (Transition Elements); N45G3015PA (Phenylglyoxal); S85X61172J (benzil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


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[PMID]:27079797
[Au] Autor:Benedetti L; Ghilardi A; Rottoli E; De Maglie M; Prosperi L; Perego C; Baruscotti M; Bucchi A; Del Giacco L; Francolini M
[Ad] Endereço:Department of Medical Biotechnology and Translational Medicine, University of Milan, Neuroscience Institute, National Research Council (CNR), Via Vanvitelli 32, 20139 Milano, Italy.
[Ti] Título:INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model.
[So] Source:Sci Rep;6:24515, 2016 Apr 15.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The pathogenic role of SOD1 mutations in amyotrophic lateral sclerosis (ALS) was investigated using a zebrafish disease model stably expressing the ALS-linked G93R mutation. In addition to the main pathological features of ALS shown by adult fish, we found remarkably precocious alterations in the development of motor nerve circuitry and embryo behavior, and suggest that these alterations are prompted by interneuron and motor neuron hyperexcitability triggered by anomalies in the persistent pacemaker sodium current INaP. The riluzole-induced modulation of INaP reduced spinal neuron excitability, reverted the behavioral phenotypes and improved the deficits in motor nerve circuitry development, thus shedding new light on the use of riluzole in the management of ALS. Our findings provide a valid phenotype-based tool for unbiased in vivo drug screening that can be used to develop new therapies.
[Mh] Termos MeSH primário: Potenciais de Ação/efeitos dos fármacos
Potenciais de Ação/genética
Esclerose Amiotrófica Lateral/genética
Neurônios Motores/efeitos dos fármacos
Neurônios Motores/fisiologia
Fenilglioxal/análogos & derivados
Superóxido Dismutase/genética
[Mh] Termos MeSH secundário: Esclerose Amiotrófica Lateral/diagnóstico
Animais
Animais Geneticamente Modificados
Modelos Animais de Doenças
Expressão Gênica
Locomoção
Atividade Motora/efeitos dos fármacos
Músculos/patologia
Mutação
Junção Neuromuscular/metabolismo
Fenótipo
Fenilglioxal/farmacologia
Riluzol/farmacologia
Medula Espinal/patologia
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
532-54-7 (isonitrosoacetophenone); 7LJ087RS6F (Riluzole); EC 1.15.1.1 (Superoxide Dismutase); N45G3015PA (Phenylglyoxal)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE
[do] DOI:10.1038/srep24515


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[PMID]:27005702
[Au] Autor:Thompson DA; Ng R; Dawson PE
[Ad] Endereço:Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd., San Diego, CA, 92037, USA.
[Ti] Título:Arginine selective reagents for ligation to peptides and proteins.
[So] Source:J Pept Sci;22(5):311-9, 2016 May.
[Is] ISSN:1099-1387
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new class of arginine-specific bioconjugation reagents for protein labeling has been developed. This method utilizes a triazolyl-phenylglyoxal group on the probe molecule that reacts selectively with the guandinyl group of Arg residues in a protein or peptide. The reaction proceeds in neutral to basic bicarbonate buffers and is selective for arginine residues in peptides and folded proteins. Importantly, the triazolyl-phenylglyoxal group can be introduced into complex molecules containing alkyne groups using CuAAC chemistry, providing a robust approach for the generation of phenylglyoxal reactive groups into molecules to be covalently attached onto the surface of proteins. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Arginina/metabolismo
Sondas Moleculares/síntese química
Peptídeos/química
Proteínas/química
Triazóis/química
[Mh] Termos MeSH secundário: Indicadores e Reagentes
Sondas Moleculares/química
Sondas Moleculares/metabolismo
Estrutura Molecular
Fenilglioxal/química
Dobramento de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indicators and Reagents); 0 (Molecular Probes); 0 (Peptides); 0 (Proteins); 0 (Triazoles); 94ZLA3W45F (Arginine); N45G3015PA (Phenylglyoxal)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.1002/psc.2867


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[PMID]:26592593
[Au] Autor:Khang J; Kim D; Chung KW; Lee JH
[Ad] Endereço:Luminescent MD, LLC, Hagerstown, MD 21742, United States.
[Ti] Título:Chemiluminescent aptasensor capable of rapidly quantifying Escherichia Coli O157:H7.
[So] Source:Talanta;147:177-83, 2016 Jan 15.
[Is] ISSN:1873-3573
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cost-effective and easy-to-use biosensor was developed for the rapid quantification and monitoring of Escherichia (E.) Coli O157:H7 in sample using E. Coli O157:H7 aptamer, graphene oxide (GO)/iron nanocomposites, and guanine chemiluminescence detection. E. Coli O157:H7 aptamer-conjugated 6-carboxyfluorescein (6-FAM) with excellent specificity captured E. Coli O157:H7 in a sample when the mixture was incubated for 1h at 37°C. Free E. Coli O157:H7 aptamers remaining in sample after the incubation were removed with GO/iron nanocomposites based on the principle of π-π stacking interaction between free aptamer and GO/iron nanocomposites. Then, E. Coli O157:H7 bound with aptamer-conjugated 6-FAM in sample emitted strong light when guanine chemiluminescent reagents (e.g., 3,4,5-trimethoxylphenylglyoxal hydrate, Tetra-n-propylammonium hydroxide) were added in the sample. The strength of light emitted in guanine chemiluminescence reaction was proportionally enhanced with the increase of E. Coli O157:H7 concentration. The limit of detection (LOD) of biosensor capable of quantifying E. Coli O157:H7 with good accuracy, precision, and reproducibility was as low as 4.5×10(3)cfu/ml. We expect that the rapid analytical system can be applied in the field of food safety as well as public health.
[Mh] Termos MeSH primário: Aptâmeros de Nucleotídeos/metabolismo
Técnicas Biossensoriais/métodos
Escherichia coli O157/isolamento & purificação
[Mh] Termos MeSH secundário: Compostos de Amônio/química
Aptâmeros de Nucleotídeos/química
Aptâmeros de Nucleotídeos/genética
Sequência de Bases
Escherichia coli O157/metabolismo
Corantes Fluorescentes/química
Grafite/química
Guanina/química
Limite de Detecção
Medições Luminescentes
Óxidos/química
Fenilglioxal/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Aptamers, Nucleotide); 0 (Fluorescent Dyes); 0 (Oxides); 5Z93L87A1R (Guanine); 7782-42-5 (Graphite); N45G3015PA (Phenylglyoxal)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151123
[Lr] Data última revisão:
151123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE


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[PMID]:26507762
[Au] Autor:Roy B; Shanmugaraju S; Saha R; Mukherjee PS
[Ad] Endereço:Department of Inorganic and Physical Chemistry Indian Institute of Science Bangalore-560012, India.
[Ti] Título:Self-assembly of Metallamacrocycles Employing a New Benzil-based Organometallic Bisplatinum(II) Acceptor.
[So] Source:Chimia (Aarau);69(9):541-6, 2015.
[Is] ISSN:0009-4293
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A benzil-based semi-rigid dinuclear-organometallic acceptor 4,4'-bis[trans-Pt(PEt(3))(2)(NO(3))(ethynyl)]benzil (bisPt-NO(3)) containing a Pt-ethynyl functionality was synthesized in good yield and characterized by multinuclear NMR ((1)H, (31)P, and (13)C), electrospray ionization mass spectrometry (ESI-MS), and single-crystal X-ray diffraction analysis of the iodide analogue bisPt-I. The stoichiometric (1:1) combination of the acceptor bisPt-NO(3) separately with four different ditopic donors (L(1)-L(4); L(1) = 9-ethyl-3,6-di(1H-imidazol-1-yl)-9H-carbazole, L(2) = 1,4-bis((1H-imidazol-1-yl)methyl)benzene, L(3) = 1,3-bis((1H-imidazol-1-yl)methyl)benzene and L(4) = 9,10-bis((1H-imidazol-1-yl) methyl)anthracene) yielded four [2 + 2] self-assembled metallacycles M(1)-M(4) in quantitative yields, respectively. All these newly synthesized assemblies were characterized by various spectroscopic techniques (NMR, IR, ESI-MS) and their sizes/shapes were predicted through geometry optimization employing the PM6 semi-empirical method. The benzil moiety was introduced in the backbone of the acceptor bisPt-NO(3) due to the interesting structural feature of long carbonyl C-C bond (∼1.54 Å), which enabled us to probe the role of conformational flexibility on size and shapes of the resulting coordination ensembles.
[Mh] Termos MeSH primário: Compostos Macrocíclicos/química
Compostos Organometálicos/química
Fenilglioxal/análogos & derivados
Platina/química
[Mh] Termos MeSH secundário: Desenho de Drogas
Compostos Macrocíclicos/síntese química
Modelos Moleculares
Conformação Molecular
Fenilglioxal/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Macrocyclic Compounds); 0 (Organometallic Compounds); 49DFR088MY (Platinum); N45G3015PA (Phenylglyoxal); S85X61172J (benzil)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:151028
[Lr] Data última revisão:
151028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE
[do] DOI:10.2533/chimia.2015.541


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[PMID]:25875038
[Au] Autor:Hensen SM; Boelens WC; Bonger KM; van Cruchten RT; van Delft FL; Pruijn GJ
[Ad] Endereço:Department of Biomolecular Chemistry, Institute for Molecules and Materials, Radboud Institute for Molecular Life Sciences and Netherlands Proteomics Centre, Radboud University Nijmegen, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands. sannehensen@gmail.com.
[Ti] Título:Phenylglyoxal-based visualization of citrullinated proteins on Western blots.
[So] Source:Molecules;20(4):6592-600, 2015 Apr 14.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Citrullination is the conversion of peptidylarginine to peptidylcitrulline, which is catalyzed by peptidylarginine deiminases. This conversion is involved in different physiological processes and is associated with several diseases, including cancer and rheumatoid arthritis. A common method to detect citrullinated proteins relies on anti-modified citrulline antibodies directed to a specific chemical modification of the citrulline side chain. Here, we describe a versatile, antibody-independent method for the detection of citrullinated proteins on a membrane, based on the selective reaction of phenylglyoxal with the ureido group of citrulline under highly acidic conditions. The method makes use of 4-azidophenylglyoxal, which, after reaction with citrullinated proteins, can be visualized with alkyne-conjugated probes. The sensitivity of this procedure, using an alkyne-biotin probe, appeared to be comparable to the antibody-based detection method and independent of the sequence surrounding the citrulline.
[Mh] Termos MeSH primário: Western Blotting
Citrulina/química
Fenilglioxal/química
Proteínas/química
[Mh] Termos MeSH secundário: Animais
Western Blotting/métodos
Catálise
Seres Humanos
Hidrolases/metabolismo
Indicadores e Reagentes/química
Desiminases de Arginina em Proteínas
Proteínas/metabolismo
Coloração e Rotulagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Indicators and Reagents); 0 (Proteins); 29VT07BGDA (Citrulline); EC 3.- (Hydrolases); EC 3.5.3.15 (Protein-Arginine Deiminases); N45G3015PA (Phenylglyoxal)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150416
[St] Status:MEDLINE
[do] DOI:10.3390/molecules20046592


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[PMID]:25854752
[Au] Autor:Arshad MN; Bibi A; Mahmood T; Asiri AM; Ayub K
[Ad] Endereço:Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia. mnchemist@hotmail.com.
[Ti] Título:Synthesis, crystal structures and spectroscopic properties of triazine-based hydrazone derivatives; a comparative experimental-theoretical study.
[So] Source:Molecules;20(4):5851-74, 2015 Apr 03.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:We report here a comparative theoretical and experimental study of four triazine-based hydrazone derivatives. The hydrazones are synthesized by a three step process from commercially available benzil and thiosemicarbazide. The structures of all compounds were determined by using the UV-Vis., FT-IR, NMR (1H and 13C) spectroscopic techniques and finally confirmed unequivocally by single crystal X-ray diffraction analysis. Experimental geometric parameters and spectroscopic properties of the triazine based hydrazones are compared with those obtained from density functional theory (DFT) studies. The model developed here comprises of geometry optimization at B3LYP/6-31G (d, p) level of DFT. Optimized geometric parameters of all four compounds showed excellent correlations with the results obtained from X-ray diffraction studies. The vibrational spectra show nice correlations with the experimental IR spectra. Moreover, the simulated absorption spectra also agree well with experimental results (within 10-20 nm). The molecular electrostatic potential (MEP) mapped over the entire stabilized geometries of the compounds indicated their chemical reactivates. Furthermore, frontier molecular orbital (electronic properties) and first hyperpolarizability (nonlinear optical response) were also computed at the B3LYP/6-31G (d, p) level of theory.
[Mh] Termos MeSH primário: Hidrazonas/síntese química
Fenilglioxal/análogos & derivados
Semicarbazidas/química
Triazinas/química
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Hidrazonas/química
Ligações de Hidrogênio
Modelos Moleculares
Conformação Molecular
Estrutura Molecular
Fenilglioxal/química
Eletricidade Estática
Triazinas/síntese química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydrazones); 0 (Semicarbazides); 0 (Triazines); 6056O8W6ET (thiosemicarbazide); N45G3015PA (Phenylglyoxal); S85X61172J (benzil)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150409
[Lr] Data última revisão:
150409
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150410
[St] Status:MEDLINE
[do] DOI:10.3390/molecules20045851


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[PMID]:25658943
[Au] Autor:Djami-Tchatchou AT; Maake MP; Piater LA; Dubery IA
[Ad] Endereço:Department of Biochemistry, University of Johannesburg, Auckland Park, South Africa.
[Ti] Título:Isonitrosoacetophenone drives transcriptional reprogramming in Nicotiana tabacum cells in support of innate immunity and defense.
[So] Source:PLoS One;10(2):e0117377, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants respond to various stress stimuli by activating broad-spectrum defense responses both locally as well as systemically. As such, identification of expressed genes represents an important step towards understanding inducible defense responses and assists in designing appropriate intervention strategies for disease management. Genes differentially expressed in tobacco cell suspensions following elicitation with isonitrosoacetophenone (INAP) were identified using mRNA differential display and pyro-sequencing. Sequencing data produced 14579 reads, which resulted in 198 contigs and 1758 singletons. Following BLAST analyses, several inducible plant defense genes of interest were identified and classified into functional categories including signal transduction, transcription activation, transcription and protein synthesis, protein degradation and ubiquitination, stress-responsive, defense-related, metabolism and energy, regulation, transportation, cytoskeleton and cell wall-related. Quantitative PCR was used to investigate the expression of 17 selected target genes within these categories. Results indicate that INAP has a sensitising or priming effect through activation of salicylic acid-, jasmonic acid- and ethylene pathways that result in an altered transcriptome, with the expression of genes involved in perception of pathogens and associated cellular re-programming in support of defense. Furthermore, infection assays with the pathogen Pseudomonas syringae pv. tabaci confirmed the establishment of a functional anti-microbial environment in planta.
[Mh] Termos MeSH primário: Resistência à Doença/efeitos dos fármacos
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Fenilglioxal/análogos & derivados
Doenças das Plantas
Tabaco/metabolismo
Transcrição Genética/efeitos dos fármacos
[Mh] Termos MeSH secundário: Fenilglioxal/farmacologia
Células Vegetais/metabolismo
Pseudomonas syringae/metabolismo
Tabaco/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
532-54-7 (isonitrosoacetophenone); N45G3015PA (Phenylglyoxal)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0117377



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