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Pesquisa : D02.065.199.092.250 [Categoria DeCS]
Referências encontradas : 36 [refinar]
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[PMID]:10489266
[Au] Autor:Fairweather I; Boray JC
[Ad] Endereço:School of Biology and Biochemistry, The Queen's University of Belfast, Belfast, Northern Ireland, BT9 7BL, UK. i.fairweather@qub.ac.uk
[Ti] Título:Fasciolicides: efficacy, actions, resistance and its management.
[So] Source:Vet J;158(2):81-112, 1999 Sep.
[Is] ISSN:1090-0233
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The modes of action of fasciolicides are described. Closantel and other salicylanilides interfere with energy metabolism by uncoupling oxidative phosphorylation in the fluke. Other fasciolicides are believed to have a metabolic action-halogenated phenols (via uncoupling) and clorsulon (via inhibition of glycolysis)-but direct evidence is lacking. Benzimidazoles (in particular, triclabendazole) bind to fluke tubulin and disrupt microtubule-based processes. Diamphenethide inhibits protein synthesis in the fluke. Other potential drug actions may contribute to overall drug efficacy. In particular, a number of fasciolicides-salicylanilides, phenols, diamphenethide-induce a rapid paralysis of the fluke, so their action may have a neuromuscular basis, although the actions remain ill-defined. Resistance to salicylanilides and triclabendazole has been detected in the field, although drug resistance does not appear to be a major problem yet. Strategies to minimize the development of resistance include the use of synergistic drug combinations, together with the design of integrated management programmes and the search for alternatives to drugs, in particular, vaccines.
[Mh] Termos MeSH primário: Anti-Helmínticos/normas
Fasciola hepatica/efeitos dos fármacos
Fasciolíase/veterinária
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/farmacologia
Anti-Helmínticos/uso terapêutico
Benzimidazóis/farmacologia
Benzimidazóis/normas
Benzimidazóis/uso terapêutico
Diamfenetida/farmacologia
Diamfenetida/normas
Diamfenetida/uso terapêutico
Resistência a Medicamentos
Fasciola hepatica/patogenicidade
Fasciolíase/tratamento farmacológico
Microscopia Eletrônica/veterinária
Microscopia Eletrônica de Varredura/veterinária
Nitroxinila/farmacologia
Nitroxinila/normas
Nitroxinila/uso terapêutico
Salicilanilidas/farmacologia
Salicilanilidas/normas
Salicilanilidas/uso terapêutico
Sulfanilamidas/farmacologia
Sulfanilamidas/normas
Sulfanilamidas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Benzimidazoles); 0 (Salicylanilides); 0 (Sulfanilamides); 4784C8E03O (triclabendazole); 9L0EXQ7125 (Nitroxinil); EG1ZDO6LRD (clorsulon); EUL532EI54 (closantel); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:9911
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:990918
[St] Status:MEDLINE


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[PMID]:7601590
[Au] Autor:Anderson HR; Fairweather I
[Ad] Endereço:School of Biology and Biochemistry, Queen's University of Belfast, U.K.
[Ti] Título:Fasciola hepatica: ultrastructural changes to the tegument of juvenile flukes following incubation in vitro with the deacetylated (amine) metabolite of diamphenethide.
[So] Source:Int J Parasitol;25(3):319-33, 1995 Mar.
[Is] ISSN:0020-7519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ultrastructural changes to the tegument of 5-week-old, 3-week-old and freshly-excysted Fasciola hepatica following in vitro incubation with the deacetylated (amine) metabolite of diamphenethide (DAMD, 10 microgramsml-1) were examined by transmission electron microscopy. A similar sequence of tegumental changes occurred in all three age groups of fluke, although, with increasing fluke age, the time before onset increased and the damage became more extensive. The 5-week-old flukes showed an initial stress response after 3 h, typified by blebbing of the apical plasma membrane, formation of microvilli and an accumulation and accelerated release of secretory bodies at the tegumental apex, as well as swelling of the basal infolds. The swelling increased in extent with progressively longer periods of incubation in DAMD, leading to extreme edema and sloughing of the tegument after 9 h. The 3-week-old flukes showed a stress response and swelling of the basal infolds after only 1.5 h, although sloughing of the tegument did not occur until after 9 h. In the freshly-excysted metacercaria, a stress response and some sloughing of the tegument were evident after only 0.5 h. At all stages of development, the ventral tegument was more severely affected than the dorsal. Changes also occurred to the tegumental cells which were indicative of a disruption in the synthesis and release of tegumental secretory bodies: the amount of GER became reduced, the cisternae became swollen and their ribosomal covering decreased, the Golgi complexes disappeared from the cells and the numbers of secretory bodies in the cells also decreased. The heterochromatin content of the nuclei increased and eventually the tegumental cells began to break down. Again, the changes became apparent more rapidly at the earlier stages of development. The ultrastructural changes to the tegument are linked to a possible mode of action for diamphenethide as an inhibitor of protein synthesis. In turn, the results may help to explain the drug's high efficacy against juvenile stages of F. hepatica.
[Mh] Termos MeSH primário: Antiplatelmínticos/farmacologia
Diamfenetida/análogos & derivados
Fasciola hepatica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Núcleo Celular/ultraestrutura
Diamfenetida/farmacologia
Fasciola hepatica/crescimento & desenvolvimento
Fasciola hepatica/ultraestrutura
Heterocromatina/ultraestrutura
Microscopia Eletrônica
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiplatyhelmintic Agents); 0 (Heterochromatin); 6954-41-2 (bis(beta-(4-aminophenoxy)ethyl) ether); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:9508
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950301
[St] Status:MEDLINE


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Fotocópia
[PMID]:7507903
[Au] Autor:Anderson HR; Fairweather I; Bamford DR; Montgomery WI
[Ad] Endereço:School of Biology and Biochemistry, Queen's University of Belfast, Northern Ireland.
[Ti] Título:The effect of diamphenethide on protein synthesis by the liver fluke, Fasciola hepatica.
[So] Source:Int J Parasitol;23(8):1053-62, 1993 Dec.
[Is] ISSN:0020-7519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of the deacetylated (amine) metabolite of diamphenethide (DAMD, 10 micrograms ml-1) on the uptake and incorporation by adult Fasciola hepatica of radioactively labelled precursors of DNA, RNA and protein synthesis ([3H]thymidine, [3H]uridine and [3H]leucine, respectively) was measured by liquid scintillation counting. Comparison was made between the effects of DAMD and those of specific inhibitors of DNA, RNA and protein synthesis, namely, 5-fluorouracil, cordycepin and cycloheximide, respectively. DAMD caused a significant decrease in the overall uptake and incorporation of [3H]uridine by F. hepatica, decreased the incorporation of [3H]leucine and also caused a significant decrease in the overall protein content of the flukes. The effect of DAMD was similar to that of cycloheximide (1 x 10(-3) M), a potent inhibitor of protein synthesis, which also caused a significant decrease in the incorporation of [3H]leucine by the fluke and a decrease in the overall protein content of the fluke. Cordycepin (100 micrograms ml-1) caused a significant decrease in the protein content of the fluke, but had no effect on the uptake or incorporation of [3H]uridine. 5-Fluorouracil (1 x 10(-4) M) did not affect the uptake or incorporation of [3H]thymidine, nor did it decrease the protein content of the fluke. The results indicate that DAMD inhibits protein synthesis by F. hepatica, possibly by inhibiting RNA synthesis. The results are also consistent with previous morphological investigations involving DAMD.
[Mh] Termos MeSH primário: DNA/efeitos dos fármacos
Diamfenetida/farmacologia
Fasciola hepatica/efeitos dos fármacos
Proteínas de Helminto/efeitos dos fármacos
RNA/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bovinos
DNA/biossíntese
Fasciola hepatica/metabolismo
Proteínas de Helminto/biossíntese
RNA/biossíntese
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Helminth Proteins); 63231-63-0 (RNA); 9007-49-2 (DNA); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:9403
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:931201
[St] Status:MEDLINE


  4 / 36 MEDLINE  
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Fotocópia
[PMID]:1685377
[Au] Autor:Caseby RH; Fairweather I; Harriott M
[Ad] Endereço:School of Biology and Biochemistry, Queen's University of Belfast, U.K.
[Ti] Título:The ionic response of the liver fluke, Fasciola hepatica to ouabain, monensin and the deacetylated (amine) metabolite of diamphenethide.
[So] Source:Comp Biochem Physiol A Comp Physiol;100(4):867-71, 1991.
[Is] ISSN:0300-9629
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. The ionic response of the liver fluke, Fasciola hepatica to perturbation of Na,K-pump activity has been determined by atomic absorption spectrophotometry. 2. The Na+/K(+)-ATPase inhibitor ouabain (1 x 10(-4) M) induced a marked reduction in K+ levels; Na+ and Ca2+ levels also fell. 3. The sodium ionophore monensin (1 x 10(-4) M) also caused a decrease in K+ levels, to below that of Na+. 4. Brief pretreatment with ouabain (1 x 10(-4) M, 15 min) followed by monensin treatment did not affect the decline in K+ levels, but did prevent the short-lived Na+ decline observed with monensin alone. 5. The deacetylated (amine) metabolite of the fasciolicide diamphenethide caused a short-lived drop in Na+ levels, but otherwise produced little change in ion levels within the fluke.
[Mh] Termos MeSH primário: Diamfenetida/metabolismo
Fasciola hepatica/metabolismo
Monensin/farmacologia
Ouabaína/farmacologia
[Mh] Termos MeSH secundário: Acilação
Aminas/metabolismo
Animais
Dimetil Sulfóxido/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amines); 5ACL011P69 (Ouabain); 906O0YJ6ZP (Monensin); U4TFJ7GB6T (Diamfenetide); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:9203
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910101
[St] Status:MEDLINE


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[PMID]:3413042
[Au] Autor:Fairweather I; Skuce PJ; Holmes SD
[Ad] Endereço:Department of Zoology, Queen's University, Belfast, Northern Ireland.
[Ti] Título:Diamphenethide--a reassessment of its pharmacological action.
[So] Source:Parasitol Res;74(5):456-62, 1988.
[Is] ISSN:0932-0113
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:At a concentration of 1 x 10(-4) M (28.84 micrograms/ml), with a solvent concentration of 1.0% (v/v) ethanol, the deacetylated (amine) metabolite of diamphenethide (DAMD) causes an initial stimulation of activity, followed by suppression, leading to a paralysis within 3 h. These changes are accompanied by an increase in muscle tone of more than 200 mg. However, ethanol alone at a concentration of 1.0% (v/v) causes an initial stimulation of activity and increase in muscle tone (approximately 550 mg). If the concentration of DAMD is kept at 1 x 10(-4) M (28.84 micrograms/ml) but the solvent concentration reduced [e.g., 0.05% (v/v) dimethyl sulphoxide], then only a suppression of motility and flaccid paralysis are observed. This response is also seen at the lower concentration of 10 micrograms/ml, which corresponds to the maximum blood levels of DAMD in vivo. The sodium ionophore monensin induces a suppression of motility, leading to a rapid flaccid paralysis (in approximately 1.5 h at 1 x 10(-7) M, and within a few minutes at higher concentrations). Ouabain, an inhibitor of Na+/K+-ATPase activity, also causes a suppression of motility, but this is accompanied by an increase in muscle tone, leading to a spastic paralysis (in approximately 2.5 h at 1 x 10(-3) M, and 3.5 h at 1 x 10(-4) M). Pretreatment with ouabain (1 x 10(-3) M for 15 min) followed by monensin (1 x 10(-5) M) reverses the original effect of monensin by inducing a rapid spastic paralysis (in approximately 50 min).(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Acetanilidas/farmacologia
Diamfenetida/farmacologia
Fasciola hepatica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Etanol/farmacologia
Monensin/farmacologia
Movimento/efeitos dos fármacos
Ouabaína/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetanilides); 3K9958V90M (Ethanol); 5ACL011P69 (Ouabain); 906O0YJ6ZP (Monensin); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:8809
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:880101
[St] Status:MEDLINE


  6 / 36 MEDLINE  
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Fotocópia
[PMID]:3220646
[Au] Autor:Fairweather I; Anderson HR; Threadgold LT
[Ti] Título:Fasciola hepatica: morphological changes in vitelline cells following treatment in vitro with the deacetylated (amine) metabolite of diamphenethide (DAMD).
[So] Source:Int J Parasitol;18(8):1061-9, 1988 Dec.
[Is] ISSN:0020-7519
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Acetanilidas/farmacologia
Diamfenetida/farmacologia
Fasciola hepatica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Fasciola hepatica/ultraestrutura
Microscopia Eletrônica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetanilides); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:8903
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:881201
[St] Status:MEDLINE


  7 / 36 MEDLINE  
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[PMID]:3194967
[Au] Autor:Zolotareva GN; Khrustaleva LI
[Ti] Título:[Manifestation of the mutagenic effect of acemidophen depending on its metabolism in various mammalian species (acemidophen--a promutagen)].
[Ti] Título:Proiavlenie mutagennogo éffekta atsemidofena v zavisimosti ot ego metabolizma u raznykh vidov mlekopitaiushchikh (atsemidofen--promutagen)..
[So] Source:Tsitol Genet;22(4):52-5, 1988 Jul-Aug.
[Is] ISSN:0564-3783
[Cp] País de publicação:Ukraine
[La] Idioma:rus
[Ab] Resumo:While studying the specific variability of metabolism of the fasciolacide anthelmintic acemidophen, it is found that it possesses no mutagenic activity. This activity is peculiar to its metabolite-free amine L2, formed in mice organism by deacetylation. Thus, acemidophen is shown to be promutagen.
[Mh] Termos MeSH primário: Acetanilidas/farmacologia
Anti-Helmínticos/farmacologia
Diamfenetida/farmacologia
Mutagênicos/farmacologia
[Mh] Termos MeSH secundário: Aminas/farmacocinética
Aminas/farmacologia
Aminas/urina
Animais
Anti-Helmínticos/farmacocinética
Anti-Helmínticos/urina
Biotransformação/efeitos dos fármacos
Medula Óssea/efeitos dos fármacos
Medula Óssea/ultraestrutura
Cromatografia em Camada Delgada
Aberrações Cromossômicas
Diamfenetida/análogos & derivados
Diamfenetida/farmacocinética
Diamfenetida/urina
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos CBA
Mutagênicos/farmacocinética
Mutagênicos/urina
Ratos
Especificidade da Espécie
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetanilides); 0 (Amines); 0 (Anthelmintics); 0 (Mutagens); 6954-41-2 (bis(beta-(4-aminophenoxy)ethyl) ether); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:8901
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:880701
[St] Status:MEDLINE


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[PMID]:3192355
[Au] Autor:Anderson HR; Fairweather I
[Ti] Título:Fasciola hepatica: scanning electron microscopic observations of juvenile flukes following treatment in vitro with the deacetylated (amine) metabolite of diamphenethide (DAMD).
[So] Source:Int J Parasitol;18(6):827-37, 1988 Sep.
[Is] ISSN:0020-7519
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Acetanilidas/farmacologia
Diamfenetida/farmacologia
Fasciola hepatica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Diamfenetida/análogos & derivados
Fasciola hepatica/ultraestrutura
Microscopia Eletrônica de Varredura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetanilides); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:8901
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:880901
[St] Status:MEDLINE


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[PMID]:3670897
[Au] Autor:Jenkins DC; Topley P; Rapson EB
[Ad] Endereço:Department of Biochemical Microbiology, Wellcome Research Laboratories, Beckenham, Kent.
[Ti] Título:Fasciola hepatica in vitro: increased susceptibility to fasciolicides in a defined serum-free medium.
[So] Source:Parasitology;95 ( Pt 1):165-71, 1987 Aug.
[Is] ISSN:0031-1820
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The cidal properties of some phenolic, halogenated diphenyl, salicylanilide, benzimidazole and diaminophenoxyalkane anthelmintics, against 6-week-old worms of Fasciola hepatica were assessed in vitro. In a conventional fluke culture medium containing RPMI 1640, supplemented with serum with or without rabbit erythrocytes or pink-ghosts, only the halogenated diphenyl and salicylanilide compounds showed activity at concentrations equal to or less than 100 microM. However, when basal, serum and cell-free RPMI 1640 was used, all compounds other than diamphenethide were highly active, their minimum lethal concentrations being some 25-125 times lower under these conditions. The inclusion of rabbit liver microsomes in the basal culture medium resulted in diamphenethide exhibiting cidal activity equivalent to that seen when its free-amine active metabolite was assayed. The possibility that the activity of many of these compounds was masked in vitro because of their serum binding properties is discussed. Recommendations are made that in vitro screens for new fasciolicides should be carried out in serum-free medium and that additional replicates containing mammalian liver microsomes and liver cytosolic extracts be included as means for the metabolic activation of certain otherwise undetectable prodrugs.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Fasciola hepatica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Benzimidazóis/farmacologia
Biotransformação
Bitionol/farmacologia
Sangue
Meios de Cultura
Diamfenetida/metabolismo
Diamfenetida/farmacologia
Hexaclorofeno/farmacologia
Microssomos Hepáticos
Nitroxinila/farmacologia
Pró-Fármacos
Salicilamidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Benzimidazoles); 0 (Culture Media); 0 (Prodrugs); 0 (Salicylamides); 9L0EXQ7125 (Nitroxinil); AMT77LS62O (Bithionol); IWW5FV6NK2 (Hexachlorophene); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:8711
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:870801
[St] Status:MEDLINE


  10 / 36 MEDLINE  
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Fotocópia
[PMID]:3575297
[Au] Autor:Fairweather I; Anderson HR; Baldwin TM
[Ti] Título:Fasciola hepatica: tegumental surface alterations following treatment in vitro with the deacetylated (amine) metabolite of diamphenethide.
[So] Source:Parasitol Res;73(2):99-106, 1987.
[Is] ISSN:0932-0113
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The effect of the deacetylated (amine) metabolite of diamphenethide (10 micrograms/ml) on the tegumental surface of Fasciola hepatica over a 24 h period in vitro has been determined by scanning electron microscopy. Blebbing begins around the oral sucker after 3 h and then passes backwards along the body, reaching the ventral sucker and midbody by 6 h, and finally the posterior end of the body (by 12 h). Initially, the blebs are small, the tegument surrounding the spines is swollen and the tegument generally has a smooth, swollen appearance. This submerges the spines below the body surface. At higher magnification the surface is seen to bear microvillous-like projections in addition to the blebs and surface pitting is deeper than normal. Later on, the blebs increase in size and burst, causing lesions and loss of spines. Lesions begin to appear on the oral cone and ventral sucker after 6 h, in the midbody by 12 h and on the dorsal surface of the posterior region after 24 h. By this time the damage is extensive: around the oral and ventral suckers, and over large areas of the oral cone and midbody region the tegument has been stripped off to expose the basal lamina beneath. The dorsal surface of the fluke is consistently more severely affected than the ventral surface.
[Mh] Termos MeSH primário: Acetanilidas/farmacologia
Diamfenetida/farmacologia
Fasciola hepatica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Diamfenetida/análogos & derivados
Fasciola hepatica/ultraestrutura
Cinética
Microscopia Eletrônica de Varredura
Ratos
Ratos Endogâmicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetanilides); 6954-41-2 (bis(beta-(4-aminophenoxy)ethyl) ether); U4TFJ7GB6T (Diamfenetide)
[Em] Mês de entrada:8706
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:870101
[St] Status:MEDLINE



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