Base de dados : MEDLINE
Pesquisa : D02.065.199.326 [Categoria DeCS]
Referências encontradas : 454 [refinar]
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[PMID]:28799017
[Au] Autor:Archana G; Dhodapkar R; Kumar A
[Ad] Endereço:Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440010, India.
[Ti] Título:Ecotoxicological risk assessment and seasonal variation of some pharmaceuticals and personal care products in the sewage treatment plant and surface water bodies (lakes).
[So] Source:Environ Monit Assess;189(9):446, 2017 Aug 10.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper reports the seasonal variation and environmental quality control data for five fingerprint pharmaceuticals and personal care products (PPCPs) (acetaminophen ciprofloxacin, caffeine, irgasan and benzophenone) in the influent and the effluent of the sewage treatment plant (STP) and surface water bodies (six major lakes) in and around Nagpur, one of the "A class city" in the central India over a period of 1 year. The target compounds were analysed using developed offline solid-phase extraction (SPE) coupled with reversed phase high-performance liquid chromatography (RP-HPLC-PDA) method. All the five PPCPs were found in the influent, whereas four were found in the effluent of the STP. However, in the surface water bodies, three PPCPs were detected in all the seasons. Above PPCPs were present in the concentration range of 1-174 µg L in the surface water bodies, 12-373 µg L in the influent and 11-233 µg L in the effluent of the STP. Amongst the five PPCPs, caffeine was found to be in higher concentration as compared to others. The seasonal trends indicate higher concentrations of PPCPs in summer season and lowest in the rainy season. Additionally, physico-chemical characterisations (inorganic and organic parameters) of the collected samples were performed to access the anthropogenic pollution. Ecotoxicological risk assessment was done to appraise the degree of toxicity of the targeted compounds. Hazard quotient (HQ) values were found to be < 1 indicating no adverse effect on the targeted organism.
[Mh] Termos MeSH primário: Cosméticos/análise
Monitoramento Ambiental
Lagos/química
Preparações Farmacêuticas/análise
Eliminação de Resíduos Líquidos
Águas Residuais/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Benzofenonas
Carbanilidas
Cromatografia de Fase Reversa
Cidades
Ecotoxicologia
Índia
Medição de Risco
Estações do Ano
Esgotos/análise
Extração em Fase Sólida
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzophenones); 0 (Carbanilides); 0 (Cosmetics); 0 (Pharmaceutical Preparations); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical); 701M4TTV9O (benzophenone); I5ZZY3DC5G (cloflucarban)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6148-3


  2 / 454 MEDLINE  
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[PMID]:28797064
[Au] Autor:Mohammad H; Younis W; Ezzat HG; Peters CE; AbdelKhalek A; Cooper B; Pogliano K; Pogliano J; Mayhoub AS; Seleem MN
[Ad] Endereço:Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, United States of America.
[Ti] Título:Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus.
[So] Source:PLoS One;12(8):e0182821, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bacterial resistance to antibiotics remains an imposing global public health challenge. Of the most serious pathogens, methicillin-resistant Staphylococcus aureus (MRSA) is problematic given strains have emerged that exhibit resistance to several antibiotic classes including ß-lactams and agents of last resort such as vancomycin. New antibacterial agents composed of unique chemical scaffolds are needed to counter this public health challenge. The present study examines two synthetic diphenylurea compounds 1 and 2 that inhibit growth of clinically-relevant isolates of MRSA at concentrations as low as 4 µg/mL and are non-toxic to human colorectal cells at concentrations up to 128 µg/mL. Both compounds exhibit rapid bactericidal activity, completely eliminating a high inoculum of MRSA within four hours. MRSA mutants exhibiting resistance to 1 and 2 could not be isolated, indicating a low likelihood of rapid resistance emerging to these compounds. Bacterial cytological profiling revealed the diphenylureas exert their antibacterial activity by targeting bacterial cell wall synthesis. Both compounds demonstrate the ability to resensitize vancomycin-resistant Staphylococcus aureus to the effect of vancomycin. The present study lays the foundation for further investigation and development of diphenylurea compounds as a new class of antibacterial agents.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Carbanilidas/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Infecções Estafilocócicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Carbanilidas/uso terapêutico
Seres Humanos
Meticilina/farmacologia
Meticilina/uso terapêutico
Resistência a Meticilina/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Vancomicina/farmacologia
Vancomicina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carbanilides); 6Q205EH1VU (Vancomycin); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182821


  3 / 454 MEDLINE  
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[PMID]:28792966
[Au] Autor:Enright HA; Falso MJS; Malfatti MA; Lao V; Kuhn EA; Hum N; Shi Y; Sales AP; Haack KW; Kulp KS; Buchholz BA; Loots GG; Bench G; Turteltaub KW
[Ad] Endereço:Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, United States of America.
[Ti] Título:Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model.
[So] Source:PLoS One;12(8):e0181996, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Triclocarban (TCC) is among the top 10 most commonly detected wastewater contaminants in both concentration and frequency. Its presence in water, as well as its propensity to bioaccumulate, has raised numerous questions about potential endocrine and developmental effects. Here, we investigated whether exposure to an environmentally relevant concentration of TCC could result in transfer from mother to offspring in CD-1 mice during gestation and lactation using accelerator mass spectrometry (AMS). 14C-TCC (100 nM) was administered to dams through drinking water up to gestation day 18, or from birth to post-natal day 10. AMS was used to quantify 14C-concentrations in offspring and dams after exposure. We demonstrated that TCC does effectively transfer from mother to offspring, both trans-placentally and via lactation. TCC-related compounds were detected in the tissues of offspring with significantly higher concentrations in the brain, heart and fat. In addition to transfer from mother to offspring, exposed offspring were heavier in weight than unexposed controls demonstrating an 11% and 8.5% increase in body weight for females and males, respectively. Quantitative real-time polymerase chain reaction (qPCR) was used to examine changes in gene expression in liver and adipose tissue in exposed offspring. qPCR suggested alterations in genes involved in lipid metabolism in exposed female offspring, which was consistent with the observed increased fat pad weights and hepatic triglycerides. This study represents the first report to quantify the transfer of an environmentally relevant concentration of TCC from mother to offspring in the mouse model and evaluate bio-distribution after exposure using AMS. Our findings suggest that early-life exposure to TCC may interfere with lipid metabolism and could have implications for human health.
[Mh] Termos MeSH primário: Carbanilidas/toxicidade
Regulação da Expressão Gênica/genética
Metabolismo dos Lipídeos/efeitos dos fármacos
Exposição Materna/efeitos adversos
Efeitos Tardios da Exposição Pré-Natal/patologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Feminino
Expressão Gênica
Fígado/metabolismo
Masculino
Camundongos
Gravidez
Reação em Cadeia da Polimerase em Tempo Real
Águas Residuais/química
Águas Residuais/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbanilides); 0 (Waste Water); 0 (Water Pollutants, Chemical); BGG1Y1ED0Y (triclocarban)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181996


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[PMID]:28703366
[Au] Autor:Ma W; Zhu M; Yang L; Yang T; Zhang Y
[Ad] Endereço:School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi, China.
[Ti] Título:Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling.
[So] Source:Phytother Res;31(9):1392-1399, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:TPD7, a novel biphenyl urea taspine derivative, and berberine have presented inhibition on VEGFR2 that can be regulated by ephrin-B2 reverse signaling through interactions with the PDZ domain. The purpose of this study is to investigate the inhibitory effect of the combination of TPD7 and berberine (TAB) on T-cell acute lymphoblastic leukemia cell growth. TPD7 and berberine together synergistically inhibited the proliferation of Jurkat cells. Also, the combination of TAB induced G -phase cell-cycle arrest by downregulating the level of cyclin D1, cyclin E, and CDC2. Furthermore, the combination of TAB significantly enhanced apoptosis in Jurkat cells, and the apoptosis most likely resulted from the modulation of the level of Bcl-2 family members. Most importantly, the concomitant treatment simultaneously regulated the ephrin-B2 and VEGFR2 signaling, as well as modulated the MEK/ERK and PTEN/PI3K/AKT/mTOR signaling. Therefore, the combination treatment of TAB may be a promising therapeutic method in treating T-cell acute lymphoblastic leukemia. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Berberina/farmacologia
Carbanilidas/farmacologia
Efrina-B2/metabolismo
Hidroxilaminas/farmacologia
Leucemia-Linfoma Linfoblástico de Células T Precursoras/patologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sinergismo Farmacológico
Seres Humanos
Células Jurkat
Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbanilides); 0 (Ephrin-B2); 0 (Hydroxylamines); 0 (TPD7 compound); 0I8Y3P32UF (Berberine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5866


  5 / 454 MEDLINE  
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[PMID]:28632490
[Au] Autor:Halden RU; Lindeman AE; Aiello AE; Andrews D; Arnold WA; Fair P; Fuoco RE; Geer LA; Johnson PI; Lohmann R; McNeill K; Sacks VP; Schettler T; Weber R; Zoeller RT; Blum A
[Ad] Endereço:Biodesign Center for Environmental Security, Arizona State University , Tempe, Arizona, USA.
[Ti] Título:The Florence Statement on Triclosan and Triclocarban.
[So] Source:Environ Health Perspect;125(6):064501, 2017 Jun 20.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as in building materials. Based on extensive peer-reviewed research, this statement concludes that triclosan and triclocarban are environmentally persistent endocrine disruptors that bioaccumulate in and are toxic to aquatic and other organisms. Evidence of other hazards to humans and ecosystems from triclosan and triclocarban is presented along with recommendations intended to prevent future harm from triclosan, triclocarban, and antimicrobial substances with similar properties and effects. Because antimicrobials can have unintended adverse health and environmental impacts, they should only be used when they provide an evidence-based health benefit. Greater transparency is needed in product formulations, and before an antimicrobial is incorporated into a product, the long-term health and ecological impacts should be evaluated. https://doi.org/10.1289/EHP1788.
[Mh] Termos MeSH primário: Anti-Infecciosos/análise
Carbanilidas/análise
Disruptores Endócrinos/análise
Poluentes Ambientais/análise
Triclosan/análise
[Mh] Termos MeSH secundário: Cosméticos
Exposição Ambiental
Política Ambiental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Carbanilides); 0 (Cosmetics); 0 (Endocrine Disruptors); 0 (Environmental Pollutants); 4NM5039Y5X (Triclosan); BGG1Y1ED0Y (triclocarban)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1289/EHP1788


  6 / 454 MEDLINE  
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[PMID]:28249208
[Au] Autor:Eissa IH; Mohammad H; Qassem OA; Younis W; Abdelghany TM; Elshafeey A; Abd Rabo Moustafa MM; Seleem MN; Mayhoub AS
[Ad] Endereço:Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
[Ti] Título:Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus.
[So] Source:Eur J Med Chem;130:73-85, 2017 Apr 21.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structure-activity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate. This compound has several notable advantages over vancomycin and linezolid including rapid killing kinetics against MRSA and the ability to target and reduce the burden of MRSA harboring inside immune cells (macrophages). Furthermore, the potent anti-MRSA activity of 21n was confirmed in vivo using a Caenorhabditis elegans animal model. The present study provides a foundation for further development of diphenylurea compounds as potential therapeutic agents to address the burgeoning challenge of bacterial resistance to antibiotics.
[Mh] Termos MeSH primário: Antibacterianos/química
Carbanilidas/química
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Resistência a Vancomicina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Caenorhabditis elegans
Carbanilidas/farmacologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Infecções Estafilocócicas/tratamento farmacológico
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carbanilides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


  7 / 454 MEDLINE  
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[PMID]:28229216
[Au] Autor:Yun H; Liang B; Kong D; Li Z; Qi G; Wang A
[Ad] Endereço:Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
[Ti] Título:Enhanced Biotransformation of Triclocarban by Ochrobactrum sp. TCC-1 Under Anoxic Nitrate Respiration Conditions.
[So] Source:Curr Microbiol;74(4):491-498, 2017 Apr.
[Is] ISSN:1432-0991
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antimicrobial triclocarban (3,4,4'-trichlorocarbanilide, TCC) is frequently detected in soils and sediments for the widely reclaim of sewage sludge or biosolid in recent decades. This resulted from a weak removal of TCC during wastewater treatment, and most of it adsorbed onto sewage sludge. As the toxicity and persistence of TCC in the environment, the elimination of TCC from the source of output is of great importance, particularly in anoxic process. In this study, the biotransformation of TCC by a newly isolated TCC-degrading strain Ochrobactrum sp. TCC-1 under anoxic conditions was investigated. By testing different carbon nitrogen ratios (C/N), it showed that nitrate could support the growth of strain TCC-1 and enhance the hydrolysis of TCC to more biodegradable chloroanilines, especially with a higher C/N of 10 and under anaerobic conditions. In wastewater sewage sludge, strain TCC-1 colonized and maintained the TCC-hydrolyzing activity under the nitrate respiration mode. These results would lay a basic foundation for the potential bioremediation of TCC-contaminated anoxic sites with TCC-degrading strain.
[Mh] Termos MeSH primário: Carbanilidas/metabolismo
Nitratos/metabolismo
Ochrobactrum/metabolismo
[Mh] Termos MeSH secundário: Carbono/metabolismo
Hidrólise
Nitrogênio/metabolismo
Esgotos/microbiologia
Eliminação de Resíduos Líquidos/métodos
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbanilides); 0 (Nitrates); 0 (Sewage); 7440-44-0 (Carbon); BGG1Y1ED0Y (triclocarban); N762921K75 (Nitrogen)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1007/s00284-017-1214-1


  8 / 454 MEDLINE  
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[PMID]:28056447
[Au] Autor:Armstrong DL; Rice CP; Ramirez M; Torrents A
[Ad] Endereço:Department of Civil and Environmental Engineering, University of Maryland, College Park, MD, USA.
[Ti] Título:Influence of thermal hydrolysis-anaerobic digestion treatment of wastewater solids on concentrations of triclosan, triclocarban, and their transformation products in biosolids.
[So] Source:Chemosphere;171:609-616, 2017 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The growing concern worldwide regarding the presence of emerging contaminants in biosolids calls for a better understanding of how different treatment technologies at water resource recovery facilities (WRRFs) can influence concentrations prior to biosolids land application. This study focuses on the influence of solids treatment via the Cambi Thermal Hydrolysis Process™ in conjunction with anaerobic digestion (TH-AD) on concentrations of triclosan (TCS), triclocarban (TCC), and their transformation products in biosolids and sludges. Concentrations of the target analytes in biosolids from the TH-AD process (Class A), sludges from the individual TH-AD treatment steps, and limed biosolids (Class B) from the same WRRF were compared. TCC concentrations were significantly lower in Class A biosolids than those in the Class B product - a removal that occurred during thermal hydrolysis. Concentrations of TCS, methyl triclosan, and 2,4-dichlorophenol, conversely, increased during anaerobic digestion, leading to significantly higher concentrations of these compounds in Class A biosolids when compared to Class B biosolids. Implementation of the TH-AD process had mixed effect on contaminant concentrations.
[Mh] Termos MeSH primário: Carbanilidas/análise
Clorofenóis/análise
Triclosan/análise
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Anaerobiose
Compostos de Cálcio
Carbanilidas/química
Carbanilidas/metabolismo
Clorofenóis/química
Clorofenóis/metabolismo
Temperatura Alta
Hidrólise
Óxidos
Triclosan/análogos & derivados
Triclosan/química
Triclosan/metabolismo
Águas Residuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Carbanilides); 0 (Chlorophenols); 0 (Oxides); 0 (Waste Water); 4NM5039Y5X (Triclosan); BGG1Y1ED0Y (triclocarban); C7X2M0VVNH (lime); R669TG1950 (2,4-dichlorophenol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


  9 / 454 MEDLINE  
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[PMID]:28025031
[Au] Autor:Wei L; Qiao P; Shi Y; Ruan Y; Yin J; Wu Q; Shao B
[Ad] Endereço:Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Triclosan/triclocarban levels in maternal and umbilical blood samples and their association with fetal malformation.
[So] Source:Clin Chim Acta;466:133-137, 2017 Mar.
[Is] ISSN:1873-3492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Triclosan (TCS) and triclocarban (TCC) are widely used as antimicrobial compounds in consumer products. TCS and TCC are frequently found in waste water and sewage. In this study, we investigate the potential impact of exposure to triclosan (TCS) and triclocarban (TCC) on fetal abnormalities. We measured TCS and TCC levels in maternal and umbilical cord blood samples from 39 pregnant women diagnosed with fetal or post-birth abnormalities at Beijing Obstetrics and Gynecology Hospital. 52 pregnant women who gave birth to healthy neonates during the same period of time were included as controls. Applying ultra-performance liquid chromatography-tandem mass spectrometry, TCS and TCC concentrations were measured in maternal and fetal sera. Significantly increased levels of TCS were detected in maternal sera from mothers with abnormal births. Similar levels of TCS or TCC were found in maternal and cord sera in control group. The concentrations of TCS or TCC in maternal sera correlated with those in umbilical cord sera (r=0.649, P<0.01). These observations suggest that maternal blood test could be a useful assay for detecting fetal exposure to TCS and TCC, and high exposure to TCS may be potentially associated with increased risk for fetal malformations.
[Mh] Termos MeSH primário: Carbanilidas/sangue
Sangue Fetal/química
Feto/anormalidades
Triclosan/sangue
Poluentes Químicos da Água/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Carbanilidas/efeitos adversos
Estudos de Casos e Controles
Feminino
Seres Humanos
Exposição Materna/efeitos adversos
Gravidez
Lesões Pré-Natais/induzido quimicamente
Soro/química
Triclosan/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbanilides); 0 (Water Pollutants, Chemical); 4NM5039Y5X (Triclosan); BGG1Y1ED0Y (triclocarban)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170826
[Lr] Data última revisão:
170826
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE


  10 / 454 MEDLINE  
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[PMID]:27988377
[Au] Autor:Hall Barrientos IJ; Paladino E; Brozio S; Passarelli MK; Moug S; Black RA; Wilson CG; Lamprou DA
[Ad] Endereço:Biomedical Engineering, University of Strathclyde, Glasgow, United Kingdom; Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, United Kingdom.
[Ti] Título:Fabrication and characterisation of drug-loaded electrospun polymeric nanofibers for controlled release in hernia repair.
[So] Source:Int J Pharm;517(1-2):329-337, 2017 Jan 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The chemical distribution and mechanical effects of drug compounds in loaded electrospun scaffolds, a potential material for hernia repair mesh, were characterised and the efficacy of the material was evaluated. Polycaprolactone electrospun fibres were loaded with either the antibacterial agent, irgasan, or the broad-spectrum antibiotic, levofloxacin. The samples were subsequently characterised by rheological studies, scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle goniometry (CAG), in vitro drug release studies, antibacterial studies and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Increased linear viscoelastic regions observed in the rheometry studies suggest that both irgasan and levofloxacin alter the internal structure of the native polymeric matrix. In vitro drug release studies from the loaded polymeric matrix showed significant differences in release rates for the two drug compounds under investigation. Irgasan showed sustained release, most likely driven by molecular diffusion through the scaffold. Conversely, levofloxacin exhibited a burst release profile indicative of phase separation at the edge of the fibres. Two scaffold types successfully inhibited bacterial growth when tested with strains of E. coli and S. aureus. Electrospinning drug-loaded polyester fibres is an alternative, feasible and effective method for fabricating non-woven fibrous meshes for controlled release in hernia repair.
[Mh] Termos MeSH primário: Carbanilidas/farmacologia
Carbanilidas/farmacocinética
Levofloxacino/farmacologia
Levofloxacino/farmacocinética
Nanofibras/química
Poliésteres/química
[Mh] Termos MeSH secundário: Carbanilidas/química
Preparações de Ação Retardada/química
Preparações de Ação Retardada/farmacocinética
Preparações de Ação Retardada/farmacologia
Liberação Controlada de Fármacos
Herniorrafia/métodos
Levofloxacino/química
Testes de Sensibilidade Microbiana
Nanofibras/ultraestrutura
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbanilides); 0 (Delayed-Action Preparations); 0 (Polyesters); 24980-41-4 (polycaprolactone); 6GNT3Y5LMF (Levofloxacin); I5ZZY3DC5G (cloflucarban)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE



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