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[PMID]:28750013
[Au] Autor:Lima AL; Barreto F; Rau RB; Silva GRD; Lara LJC; Figueiredo TC; Assis DCS; Cançado SV
[Ad] Endereço:Departamento de Tecnologia e Inspeção de Produtos de Origem Animal, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
[Ti] Título:Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration.
[So] Source:PLoS One;12(7):e0181755, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The depletion times of the anticoccidial nicarbazin administered individually and of nicarbazin and narasin administered in combination were evaluated by determining the presence and levels of 4,4'-dinitrocarbanilide (DNC), the marker residue for nicarbazin, and narasin residues in the muscle tissues of broiler chickens subjected to a pharmacological treatment. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was used. The results showed the presence of all anticoccidial residues; however, the DNC levels were higher when the nicarbazin was administered individually than when it was used in association with narasin throughout the experimental period. After six days of withdrawal, the DNC level following nicarbazin administration alone was lower than the maximum residue level (MRL) of 200 µg kg-1. However, when the nicarbazin was co-administered with narasin, the concentrations of DNC were lower than the MRL after four days of withdrawal. These results may be justified because the dosage of nicarbazin, when administrated individually, is greater than when it is used in combination with narasin. The levels of narasin were lower than the MRL of 15 µg kg-1 throughout the evaluation period. It was concluded that nicarbazin is rapidly metabolized from the broiler muscles up to six days of withdrawal since the DNC levels were lower than the maximum residue level (MRL) and the concentrations of narasin were lower than the MRL throughout the evaluation period.
[Mh] Termos MeSH primário: Coccidiostáticos/farmacocinética
Nicarbazina/farmacocinética
Piranos/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Galinhas
Coccidiostáticos/administração & dosagem
Combinação de Medicamentos
Resíduos de Drogas
Inocuidade dos Alimentos
Nicarbazina/administração & dosagem
Piranos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coccidiostats); 0 (Drug Combinations); 0 (Pyrans); 11P9NUA12U (Nicarbazin); DZY9VU539P (narasin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181755


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[PMID]:28671969
[Au] Autor:Samiullah S; Roberts J; Wu SB
[Ad] Endereço:Animal Science, School of Environmental and Rural Science, University of New England, Armidale, New South Wales, Australia.
[Ti] Título:Reference gene selection for the shell gland of laying hens in response to time-points of eggshell formation and nicarbazin.
[So] Source:PLoS One;12(7):e0180432, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ten reference genes were investigated for normalization of gene expression data in the shell gland of laying hens. Analyses performed with geNorm revealed that hypoxanthine phosphoribosyltransferase 1 (HPRT1) and hydroxymethylbilane synthase (HMBS) were the two most stable reference genes in response to post-oviposition time alone (POT) or with nicarbazin treatment (POT+N) of laying hens. NormFinder analyses showed that the two most stable reference genes in response to POT and POT+N were 18S ribosomal RNA (18S rRNA), ribosomal protein L4 (RPL4) and HMBS, RPL4, respectively. BestKeeper analyses showed that 18S rRNA, RPL4 and HPRT1, HMBS were the two most stable reference genes for POT, and POT+N, respectively. Of the ten reference genes, all except B2M showed geNorm M <0.5, suggesting that they were stably expressed in the shell gland tissue. Consensus from these three programs suggested HPRT1 and HMBS could be used as the two most stable reference genes in the present study. Expression analyses of four candidate target genes with the two most and the two least stable genes showed that a combination of stable reference genes leads to more discriminable quantification of expression levels of target genes, while the least stable genes failed to do so. Therefore, HMBS and HPRT1 are recommended as the two most stable reference genes for the normalization of gene expression data at different stages of eggshell formation in brown-egg laying hens. Available statistical programs for reference gene ranking should include more robust analysis capability to analyse the gene expression data generated from factorial design experiments.
[Mh] Termos MeSH primário: Galinhas/fisiologia
Casca de Ovo
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Hidroximetilbilano Sintase/genética
Hipoxantina Fosforribosiltransferase/genética
Nicarbazina/farmacologia
[Mh] Termos MeSH secundário: Animais
Galinhas/genética
Feminino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
11P9NUA12U (Nicarbazin); EC 2.4.2.8 (Hypoxanthine Phosphoribosyltransferase); EC 2.5.1.61 (Hydroxymethylbilane Synthase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180432


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[PMID]:26950416
[Au] Autor:Angelovicová M; Kunová S; Capla J; Zajac P; Bucko O; Angelovic M
[Ad] Endereço:a Department of Food Hygiene and Safety , Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture , Nitra , Slovak Republic.
[Ti] Título:Comparison of fatty acid profile in the chicken meat after feeding with narasin, nicarbazin and salinomycin sodium and phyto-additive substances.
[So] Source:J Environ Sci Health B;51(6):374-82, 2016.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was an experimental investigation and a statistical evaluation of the influence of various additives in feed mixtures of broiler chickens on fatty acids content and their ratio in breast and thigh muscles. First feed additive consisted of narasin, nicarbasin and salinomycin sodium, and other five additives were of phytogenic origin. In vivo experiment was realized on the poultry experimental station with deep litter breeding system. A total of 300 one-day-old hybrid chickens Cobb 500 divided into six groups were used for the experiment. The experimental period was divided into four phases, i.e. Starter, Grower 1, Grower 2 and Final, according to the application of commercial feed mixture of soy cereal type. Additive substances used in feed mixtures were different for each group. Basic feed mixtures were equal for all groups. Fatty acid profile of breast and thigh muscles was measured by the method of FT IR Nicolet 6700. Investigated additive substances in the feed mixtures did not have statistically significant effect on fatty acid content and omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratio in breast and thigh muscles. Strong statistically significant relation between omega-6 PUFAs and total PUFAs were proved by experiment. A relation between omega-3 PUFAs and total PUFAs was found only in the group with Biocitro additive.
[Mh] Termos MeSH primário: Ração Animal/análise
Galinhas
Ácidos Graxos/análise
Aditivos Alimentares/farmacologia
Carne/análise
[Mh] Termos MeSH secundário: Animais
Ácidos Graxos Ômega-3/análise
Músculo Esquelético/química
Músculo Esquelético/metabolismo
Nicarbazina/farmacologia
Piranos/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Omega-3); 0 (Food Additives); 0 (Pyrans); 11P9NUA12U (Nicarbazin); 62UXS86T64 (salinomycin); DZY9VU539P (narasin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2016.1142320


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[PMID]:26944975
[Au] Autor:Wang X; Farnell YZ; Peebles ED; Kiess AS; Wamsley KG; Zhai W
[Ad] Endereço:Department of Poultry Science, Mississippi State University, 39762.
[Ti] Título:Effects of prebiotics, probiotics, and their combination on growth performance, small intestine morphology, and resident Lactobacillus of male broilers.
[So] Source:Poult Sci;95(6):1332-40, 2016 Jun 01.
[Is] ISSN:1525-3171
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Effects of commercial antimicrobials and the individual and combinational use of commercial prebiotics and probiotics in feed from d zero to 41 on the growth performance, small intestine size, jejunal morphology, and ileal resident bacteria population of broiler chickens were determined. A total of 1,040 one-day-old male Ross × Ross 708 broilers were randomly distributed to 80 floor pens (5 treatments, 16 replications per treatment, 13 chicks per pen). Five dietary treatments were employed: 1) a corn soybean-meal basal diet (served as a negative control diet, NC); 2) a basal diet supplemented with a commercial prebiotic product (Pre); 3) a basal diet supplemented with a probiotic product containing Bacillus subtilis spores (Pro); 4) a basal diet supplemented with both prebiotic and probiotic products (Pre + Pro); and 5) a basal diet supplemented with commercial antimicrobials (served as a positive control diet, PC). At d 14, Pre diets improved the relative level of Lactobacillus in ileal mucosa as compared to NC, Pro, or PC diets (P = 0.045) without improving broiler BW. Broilers fed PC diets exhibited the highest BW gain from d 15 to 27, the lowest duodenum, jejunum, and ileum relative weights as percentage of BW at d 27, and the highest breast weight at d 42 (P = 0.026, 0.035, 0.002, 0.025, and 0.035, respectively). Broilers fed Pro or Pre + Pro diets exhibited higher BW gain from d 28 to 41 (P = 0.005) and higher overall BW gain from d zero to 41 (P = 0.039) than those fed other diets. Dietary treatments did not affect jejunal morphology or ileal resident Escherichia coli level at any age. From our results, including spores of Bacillus subtilis in feed may stimulate growth at a later age and may facilitate broilers in reaching their target weight sooner. Therefore, probiotics are recommended as potential alternatives to antimicrobials in chicken diets, especially in grower and finisher feed.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos da Nutrição Animal
Galinhas/crescimento & desenvolvimento
Intestino Delgado
Lactobacillus/fisiologia
Prebióticos
Probióticos
[Mh] Termos MeSH secundário: Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal/efeitos dos fármacos
Animais
Antibacterianos/farmacologia
Antiprotozoários/farmacologia
Bacitracina/farmacologia
Galinhas/anatomia & histologia
Galinhas/microbiologia
Dieta/veterinária
Escherichia coli/efeitos dos fármacos
Escherichia coli/fisiologia
Íleo/microbiologia
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/microbiologia
Intestino Delgado/anatomia & histologia
Intestino Delgado/microbiologia
Masculino
Nicarbazina/farmacologia
Piranos/farmacologia
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antiprotozoal Agents); 0 (Prebiotics); 0 (Pyrans); 11P9NUA12U (Nicarbazin); 1405-87-4 (Bacitracin); DZY9VU539P (narasin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160306
[St] Status:MEDLINE
[do] DOI:10.3382/ps/pew030


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[PMID]:25842215
[Au] Autor:Albonetti P; Marletta A; Repetto I; Sasso EA
[Ad] Endereço:Department of Earth Sciences, Environment and live sciences, University of Genoa, Corso Europa 26, 16132 Genoa, Italy.
[Ti] Título:Efficacy of nicarbazin (Ovistop®) in the containment and reduction of the populations of feral pigeons (Columba livia var. domestica) in the city of Genoa, Italy: a retrospective evaluation.
[So] Source:Vet Ital;51(1):63-72, 2015 Jan-Mar.
[Is] ISSN:1828-1427
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:This study describes the results of a retrospective evaluation (8 years: 2005-2012) of the efficacy of the anti-fertility drug, Ovistop® nicarbazin (800 ppm) added to corn kernels used to feed non-migratory feral pigeon colonies, Columba livia var. domestica, in the city of Genoa, Italy. The observation interested 4 non-migratory feral pigeon colonies located into well­defined areas of the city of Genoa, Italy. Three of these colonies were treated for 12 months, with 10 g of drug (Ovistop®) provided per bird per day for 5 days each week; the other colony was treated in the same way but with a placebo (control station). Each colony and the relative area where the colony was located were both monitored with the same daily examination. Statistical analysis techniques were applied to the findings recorded - both descriptive (indices of central and dispersion trends) and comparative (one-way variance analysis). In the colonies treated with the drug, following an initial increase in the population ('magnet effect'), a reduction was observed over the following 4 years (-35% >x> -45%) and a further decrease (-65% >x> -70%) was observed over the subsequent 4 years (statistically significant one-way ANOVA p<0.01). This phenomenon was recorded across the board in the 3 treated stations, compared to the overall unstable trend observed for the control station. As no external or exceptional anthropic or natural factors were observed, it can be stated that, given the results observed, the drug seemed effective in reducing the treated bird populations.
[Mh] Termos MeSH primário: Columbidae
Nicarbazina
Controle de Pragas/métodos
[Mh] Termos MeSH secundário: Animais
Cidades
Itália
Estudos Retrospectivos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
11P9NUA12U (Nicarbazin)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150406
[Lr] Data última revisão:
150406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150406
[St] Status:MEDLINE
[do] DOI:10.12834/VetIt.337.1448.3


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[PMID]:24830177
[Au] Autor:Coleman MR; Rodewald JM; Brunelle SL; Nelson M; Bailey L; Burnett TJ
[Ti] Título:Determination and confirmation of nicarbazin, measured as 4,4-dinitrocarbanilide (DNC), in chicken tissues by liquid chromatography with tandem mass spectrometry: First Action 2013.07.
[So] Source:J AOAC Int;97(2):630-40, 2014 Mar-Apr.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A single-laboratory validation (SLV) study was conducted on an LC/MS/MS method for the determination and confirmation of nicarbazin, expressed as 4,4-dinitrocarbanilide (DNC), in chicken tissues, including liver, kidney, muscle, skin with adhering fat, and eggs. Linearity was demonstrated with DNC standard curve solutions using a weighted (1/x) regression and confirmed with matrix-matched standards. Intertrial repeatability precision (relative standard deviation of repeatability; RSD(r) was from 2.5 to 11.3%, as determined in fortified tissues. The precision was verified with incurred tissue, and varied from 0.53 to 2.5%. Average recoveries ranged from 82% in egg to 98% in kidney. Although the average recoveries across all concentrations were within the acceptable range, the method was improved with the inclusion of an internal standard and the use of matrix-matched standards. Accuracy for the improved method in chicken liver varied from 93 to 99% across all concentrations (100-8000 ng/g) compared to recoveries below 80% at concentrations, between 100-400 ng/g in chicken liver for the original method. The limit of detection was estimated to be less than 3.0 ng/g in all tissue types, and the limit of quantitation was validated at 20 ng/g. Based on confirmatory ion ratios and peak retention times, the false-negative rate was estimated as 0.00% (95% confidence limits 0.00, 0.74%) from 484 fortified samples and 12 incurred residue samples analyzed using the U.S. and EU confirmation criteria. Small variations to the method parameters, with the exception of injection volume, did not have a significant effect on recoveries. Stability was determined for fortified tissues, extracts, and standard curve solutions. The data collected in this study satisfy the requirements of SLV studies established by the AOAC Stakeholder Panel for Veterinary Drug Residue and the method was awarded First Action Official Method status by the Expert Review Panel for Veterinary Drug Residues on May 7, 2013.
[Mh] Termos MeSH primário: Carbanilidas/química
Galinhas/metabolismo
Cromatografia Líquida/métodos
Rim/química
Fígado/química
Nicarbazina/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Tecido Adiposo/química
Animais
Carbanilidas/metabolismo
Cromatografia Líquida/normas
Coccidiostáticos/química
Coccidiostáticos/metabolismo
Ovos/análise
Músculo Esquelético/química
Nicarbazina/metabolismo
Pele/química
Espectrometria de Massas em Tandem/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbanilides); 0 (Coccidiostats); 11P9NUA12U (Nicarbazin); 9IDD210E75 (4,4'-dinitrocarbanilide)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:140516
[Lr] Data última revisão:
140516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140517
[St] Status:MEDLINE


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[PMID]:24779872
[Au] Autor:Bilandzic N; Dolenc J; Gacnik KS; Varenina I; Kolanovic BS
[Ad] Endereço:a Department of Veterinary Public Health, Laboratory for Residue Control , Croatian Veterinary Institute , Zagreb , Croatia.
[Ti] Título:Feed additives diclazuril and nicarbazin in egg and liver samples from Croatian farms.
[So] Source:Food Addit Contam Part B Surveill;6(2):90-7, 2013.
[Is] ISSN:1939-3229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In total 307 egg and 275 liver samples were examined for nicarbazin and 365 eggs for diclazuril over a 30-month period. Enzyme-linked immunosorbent assay methods used for quantification were validated according to European Commission Decision 2002/657/EC. Non-compliant samples were confirmed by LC-MS/MS. Mean diclazuril concentrations in egg samples were 0.31 µg kg⁻¹, which is below the MRL. In only one egg sample, 2.26 µg kg⁻¹ was determined by enzyme-linked immunosorbent assay, although confirmation by LC-MS/MS gave a value of 1.6 µg kg(-1). Mean nicarbazin levels determined were 1.85 µg kg⁻¹ in egg and 21.1 µg kg⁻¹ in liver samples. Four samples, one egg and three livers, yielded elevated concentrations of nicarbazin, but only in the egg sample the LC-MS/MS method confirmed nicarbazin (106 µg kg⁻¹) above the MRL value.
[Mh] Termos MeSH primário: Coccidiostáticos/análise
Resíduos de Drogas/análise
Ovos/análise
Contaminação de Alimentos
Inspeção de Alimentos/métodos
Fígado/química
Carne/análise
[Mh] Termos MeSH secundário: Animais
Galinhas
Cromatografia Líquida de Alta Pressão
Croácia
Ovos/normas
Ensaio de Imunoadsorção Enzimática
União Europeia
Inspeção de Alimentos/normas
Fidelidade a Diretrizes
Limite de Detecção
Carne/normas
Nicarbazina/análise
Nitrilos/análise
Reprodutibilidade dos Testes
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
Triazinas/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Coccidiostats); 0 (Nitriles); 0 (Triazines); 11P9NUA12U (Nicarbazin); K110K1B1VE (diclazuril)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140501
[St] Status:MEDLINE
[do] DOI:10.1080/19393210.2012.727474


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[PMID]:24645501
[Au] Autor:Moretti S; Fioroni L; Giusepponi D; Pettinacci L; Saluti G; Galarini R
[Ti] Título:Development and validation of a multiresidue liquid chromatography/tandem mass spectrometry method for 11 coccidiostats in feed.
[So] Source:J AOAC Int;96(6):1245-57, 2013 Nov-Dec.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A confirmatory method for the determination of 11 regulated coccidiostats including the ionophore antibiotics lasalocid, maduramicin, monensin, narasin, salinomycin, and semduramicin and the chemical coccidiostats decoquinate, diclazuril, halofuginone, nicarbazin, and robenidine in animal feed was developed and validated. The procedure was intended for the identification and quantification of the coccidiostats at concentrations relating both to the unintentional carryover as stated in Regulation 574/2011 and to the authorized levels in target feed. The analytes were determined by LC/MS/MS in the positive or negative electrospray ionization mode. The method performance characteristics were estimated in the relevant application field from 0.003 to 200 mg/kg. Validation criteria of linearity, specificity, trueness, precision, LOD, and LOQ along with measurement uncertainty were estimated for all analytes. Absolute and relative matrix effects were also studied. The results proved that the method performance was satisfactory, and it was successfully applied to carryover control by analyzing 165 feed samples collected within regulatory monitoring plans. Finally, since the carryover phenomenon in feed may result in the presence of residues in food products of animal origin, a survey has been carried out on the occurrence of coccidiostats in 167 eggs and animal muscles.
[Mh] Termos MeSH primário: Ração Animal/análise
Cromatografia Líquida/métodos
Coccidiostáticos/química
Resíduos de Drogas/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Calibragem
Bovinos
Coccidiostáticos/análise
Decoquinato/análise
Contaminação de Alimentos
Lactonas/análise
Lasalocida/análise
Monensin/análise
Músculos/química
Nicarbazina/análise
Nigericina/análogos & derivados
Nigericina/análise
Nitrilos/análise
Piperidinas/análise
Aves Domésticas
Piranos/análise
Quinazolinonas/análise
Coelhos
Robenidina/análise
Ovinos
Espectrometria de Massas por Ionização por Electrospray/métodos
Suínos
Triazinas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Coccidiostats); 0 (Lactones); 0 (Nitriles); 0 (Piperidines); 0 (Pyrans); 0 (Quinazolinones); 0 (Triazines); 11P9NUA12U (Nicarbazin); 4888ME6C4E (Robenidine); 534I52PVWH (Decoquinate); 5U912U22T2 (maduramicin); 62UXS86T64 (salinomycin); 906O0YJ6ZP (Monensin); DZY9VU539P (narasin); K110K1B1VE (diclazuril); L31MM1385E (halofuginone); P6VXL377WL (semduramicin); RRU6GY95IS (Nigericin); W7V2ZZ2FWB (Lasalocid)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140321
[St] Status:MEDLINE


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[PMID]:24437093
[Au] Autor:MacDonald A; Wolf E
[Ad] Endereço:Innolytics, LLC, Rancho Santa Fe, California 92067, USA.
[Ti] Título:The political and social barriers for contraception in pest birds: a case study of Ovocontrol (nicarbazin).
[So] Source:J Zoo Wildl Med;44(4 Suppl):S132-4, 2013 Dec.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In a joint program, Innolytics and the U.S. Department of Agriculture/Animal and Plant Health Inspection Service National Wildlife Research Center collaborated in the development of nicarbazin as an avian contraceptive, initially for resident Canada geese and subsequently for feral pigeons. Unfortunately, the introduction of the original goose product in 2005 was a commercial failure. Political and social barriers effectively thwarted attempts to establish the new technology with any meaningful market success. Although the market adoption of the pigeon contraceptive has been less difficult, the product still encounters significant social and political obstacles and opposition. Given the focus on instant results and gratification, the introduction of contraceptive technology for birds has been challenging and broad market acceptance remains elusive. Nevertheless, especially for short-lived and rapidly reproducing species, customers continue to replace outdated or ineffective techniques with the safer and more effective contraceptive tool.
[Mh] Termos MeSH primário: Anseriformes
Coccidiostáticos/farmacologia
Columbidae
Anticoncepção/veterinária
Nicarbazina/farmacologia
Controle de Pragas/métodos
[Mh] Termos MeSH secundário: Animais
Anticoncepcionais/farmacologia
Política
Controle da População
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coccidiostats); 0 (Contraceptive Agents); 11P9NUA12U (Nicarbazin)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:140120
[Lr] Data última revisão:
140120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140121
[St] Status:MEDLINE


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[PMID]:22970563
[Au] Autor:Burnett TJ; Lombardi K; Rodewald JM; Brunelle SL; MacDougall J; Coleman MR
[Ad] Endereço:Elanco Animal Health, 2500 Innovation Way, Greenfield, IN 46140, USA. tjburnett@elanco.com
[Ti] Título:Determination of narasin and monensin in bovine, swine, and chicken tissues by liquid chromatography with tandem mass spectrometry: first action 2011.24.
[So] Source:J AOAC Int;95(4):959-91, 2012 Jul-Aug.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The single-laboratory validation (SLV) of an LC-MS/MS method for determination and confirmation of two ionophores, narasin and monensin, in animal tissues is described. The data demonstrated linearity of matrix-matched calibration curves using a weighted (1/x) regression and selectivity of the method for narasin and monensin in the presence of lasalocid, salinomycin, maduramycin, nicarbazin, and sulfadiazine. Recoveries varied from 86.2 to 103.5% for narasin and 89.1 to 105.1% for monensin. Intertrial repeatability precision [relative standard deviation of repeatability (RSDr)] varied from 3.9 to 13.8% for narasin and 3.3 to 16.3% for monensin in fortified tissue. Precision of the method was verified in incurred tissues. The LOQ of the method was validated and ranged from 0.45 ng/g in milk, to 4.0 ng/g in chicken fat, but was 0.75 ng/g for most tissues. Two confirmatory ions for each analyte were examined across all matrixes, resulting in estimated false-negative rates of 0.00% (95% confidence interval of 0.00-0.68%) for monensin ions (540 samples) compared to the U.S. and European Union (EU) acceptance criteria. The confirmatory ions for narasin demonstrated 0.00% false-negative rates (95% confidence interval of 0.00-0.58%) when compared to either the U.S. or EU criteria in 630 samples. The method was robust when small changes in method parameters were made and stability of fortified tissues, extracts, and calibration solutions were estimated. The data satisfy the requirements of the AOAC Stakeholder Panel on Veterinary Drug Residue for SLV studies, and the method was adopted Official Methods of Analysis First Action 2011.24 by the AOAC Expert Review Panel on Veterinary Drug Residues.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Monensin/análise
Piranos/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Animais
Calibragem
Bovinos
Técnicas de Química Analítica/métodos
Química Farmacêutica/métodos
Galinhas
Avaliação Pré-Clínica de Medicamentos
Resíduos de Drogas/análise
Europa (Continente)
Reações Falso-Negativas
Lactonas/análise
Lasalocida/análise
Leite/química
Nicarbazina/análise
Análise de Regressão
Sulfadiazina/análise
Suínos
Estados Unidos
Medicina Veterinária/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lactones); 0 (Pyrans); 0N7609K889 (Sulfadiazine); 11P9NUA12U (Nicarbazin); 5U912U22T2 (maduramicin); 62UXS86T64 (salinomycin); 906O0YJ6ZP (Monensin); DZY9VU539P (narasin); W7V2ZZ2FWB (Lasalocid)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120914
[St] Status:MEDLINE



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