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[PMID]:29236389
[Au] Autor:Holota YV; Holubenko OO; Ostapchuk AM; Serhiychuk TM; Zakordonets LV; Tolstanova GM
[Ti] Título:Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats.
[So] Source:Ukr Biochem J;89(1):50-8, 2017 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Short-chain fatty acids (SCFAs) are major products of the microbial fermentation of dietary fiber in the colon. Recent studies suggest that these products of microbial metabolism in the gut act as signaling molecules, influence host energy homeostasis and play major immunological roles. In the present study, defined the long-term effects of ceftriaxone administration on the fecal SCFAs concentration in Wistar rats. Ceftriaxone (300 mg/kg, i.m.) was administered daily for 14 days. Rats were euthanized in 1, 15 and 56 days after ceftriaxone withdrawal. Caecal weight and fecal concentration of SCFAs by gas chromatography were measured. Ceftriaxone administration induced time-dependent rats' caecal enlargement through accumulation of undigestable substances. In 1 day after ceftriaxone withdrawal, the concentrations of acetic, propionic, butyric acids and total SCFAs were decreased 2.9-, 13.8-, 8.5-, 4.8-fold (P < 0.05), respectively. Concentration of valeric, isovaleric and caproic acids was below the detectable level. That was accompanied by decreased 4.3-fold anaerobic index and increased the relative amount of acetic acid (P < 0.05). In 56 days, concentration of SCFAs was still below control value but higher than in 1 day (except propionic acid). Anaerobic index was lower 1.3-fold (P < 0.05) vs. control. Conclusion: antibiotic therapy induced long-term disturbance in colonic microbiota metabolic activity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Ceftriaxona/farmacologia
Colo/efeitos dos fármacos
Ácidos Graxos Voláteis/metabolismo
Fezes/química
[Mh] Termos MeSH secundário: Ácido Acético/metabolismo
Animais
Butiratos/metabolismo
Caproatos/metabolismo
Colo/metabolismo
Esquema de Medicação
Ácidos Graxos Voláteis/antagonistas & inibidores
Injeções Intramusculares
Masculino
Ácidos Pentanoicos/metabolismo
Propionatos/metabolismo
Ratos
Ratos Wistar
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Butyrates); 0 (Caproates); 0 (Fatty Acids, Volatile); 0 (Pentanoic Acids); 0 (Propionates); 1BR7X184L5 (isovaleric acid); 1F8SN134MX (hexanoic acid); 75J73V1629 (Ceftriaxone); GZK92PJM7B (n-pentanoic acid); JHU490RVYR (propionic acid); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj89.01.050


  2 / 5320 MEDLINE  
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[PMID]:29235834
[Au] Autor:Holota YV; Olefir YA; Dovbynchuk TV; Tolstanova GM
[Ti] Título:Carbohydrate composition of rat intestine surface mucus layer after ceftriaxone treatment.
[So] Source:Ukr Biochem J;88(6):35-44, 2016 Nov-Dec.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:The epidemiological studies have shown that antibiotic treatment increases the susceptibility to inflammatory bowel disease development. The disturbance of mucus layer integrity might be one of the possible mechanisms. The aim of the present study was to investigate the effect of antibiotic ceftriaxone treatment on glycoproteins level and its carbohydrate composition in surface mucus layer of rat intestine. The study was done on male Wistar rats (140-160 g). Ceftriaxone (300 mg/kg, i.m.) was administered once a day for 14 days. The surface mucus from terminal ileum and colon were collected on the 15th, 29th and 72nd days of the experiment. Total level of mucus glycoproteins, hexoses, hexosamines, fucose and sialic acids were measured. Ceftriaxone administration did not affect the levels of glycoproteins in rat ileum. In the colon, the levels of glycoprotein were 1.3-fold decreased (Р < 0.05) on the 72nd day of the experiment. These changes were accompanied by the 1.2-fold decrease of hexoses (Р < 0.05) and 3.1-fold (Р < 0.05) decrease of fucose level and 1.5-fold (Р < 0.05) increase of the levels of sialic acids in the surface mucus of the rat colon. Thus, ceftriaxone administration induces the long-term changes in the levels of glycoproteins and carbohydrates composition in the rat colon surface mucus. This could potentially explain the susceptibility to inflammatory bowel disea­ses development.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Ceftriaxona/farmacologia
Colo/efeitos dos fármacos
Íleo/efeitos dos fármacos
Muco/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Colo/química
Colo/metabolismo
Esquema de Medicação
Fucose/metabolismo
Glicoproteínas/metabolismo
Hexosaminas/metabolismo
Hexoses/metabolismo
Íleo/química
Íleo/metabolismo
Injeções Intramusculares
Masculino
Muco/química
Muco/metabolismo
Ratos
Ratos Wistar
Ácidos Siálicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glycoproteins); 0 (Hexosamines); 0 (Hexoses); 0 (Sialic Acids); 28RYY2IV3F (Fucose); 75J73V1629 (Ceftriaxone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.06.035


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[PMID]:29187685
[Au] Autor:Kajikawa S; Oeda T; Park K; Yamamoto K; Sugiyama H; Sawada H
[Ad] Endereço:Department of Neurology, Utano Hospital, National Hospital Organization.
[Ti] Título:[A case of subarachnoid hemorrhage due to infective endocarditis by methicillin-resistant coagulase-negative staphylococcus].
[So] Source:Rinsho Shinkeigaku;57(12):775-777, 2017 Dec 27.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 77-year-old man visited our hospital with unstable gait following 2 months of anorexia. Brain MRI showed multiple infarcts; cardiac echocardiography revealed mitral-valve vegetation; and blood culture revealed methicillin-resistant coagulase-negative staphylococci. The patient was diagnosed with infective endocarditis (IE). Subarachnoid hemorrhage (SAH) developed ten days after antibiotic treatment. Intracranial aneurysm was not found. We speculated that chronic inflammation of the cerebral arterial walls by bacteria of low virulence was associated with SAH complication. The vegetation disappeared following additional gentamicin administration and the patient recovered to walk.
[Mh] Termos MeSH primário: Endocardite/complicações
Endocardite/microbiologia
Staphylococcus aureus Resistente à Meticilina
Infecções Estafilocócicas
Hemorragia Subaracnóidea/etiologia
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/administração & dosagem
Ceftriaxona/administração & dosagem
Ecocardiografia Transesofagiana
Endocardite/diagnóstico por imagem
Endocardite/tratamento farmacológico
Gentamicinas/administração & dosagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Hemorragia Subaracnóidea/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Vancomicina/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gentamicins); 6Q205EH1VU (Vancomycin); 75J73V1629 (Ceftriaxone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001053


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[PMID]:29219803
[Au] Autor:Papp JR; Rowlinson MC; O'Connor NP; Wholehan J; Razeq JH; Glennen A; Ware D; Iwen PC; Lee LV; Hagan C
[Ad] Endereço:1​Centers for Disease Control and Prevention, Atlanta, GA, USA.
[Ti] Título:Accuracy and reproducibility of the Etest to detect drug-resistant Neisseria gonorrhoeae to contemporary treatment.
[So] Source:J Med Microbiol;67(1):68-73, 2018 Jan.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Neisseria gonorrhoeae is a sexually transmitted bacterial pathogen that continues to evolve to become resistant to known antibiotics. In preparing for potential emergence, the Centers for Disease Control and Prevention recommends that clinical laboratories maintain or develop protocols to assess antibiotic susceptibly for this organism. This study examines the intra-laboratory variability of using the Etest method to provide consistent MIC values for N. gonorrhoeae and also compared the results of the Etest to known agar dilution MIC values. METHODOLOGY: Clinical N. gonorrhoeae isolates, 100 paired duplicates, were tested by eight laboratories for antibiotic susceptibility to ceftriaxone, cefixime and azithromycin using Etest strips.Results/Key findings. Overall, >80 % of the paired Etest MIC values were within one log2 dilution of the replicate. When compared to the agar dilution reference method, the cefixime Etest MIC values were consistently underreported by one dilution (seven laboratories) or two dilutions (one laboratory). The azithromycin Etest MIC values agreed 90.7 % with the agar dilution MIC values while the agreement with ceftriaxone was 90.9 %. CONCLUSION: Overall, the Etest method yielded reproducible MIC values within each laboratory with the azithromycin and ceftriaxone MIC results consistent to the reference agar dilution method while the cefixime result tended to provide a lower MIC value.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Neisseria gonorrhoeae/efeitos dos fármacos
Neisseria gonorrhoeae/isolamento & purificação
[Mh] Termos MeSH secundário: Azitromicina/farmacologia
Cefixima/farmacologia
Ceftriaxona/farmacologia
Gonorreia/microbiologia
Seres Humanos
Testes de Sensibilidade Microbiana/métodos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 75J73V1629 (Ceftriaxone); 83905-01-5 (Azithromycin); 97I1C92E55 (Cefixime)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000651


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[PMID]:29045497
[Au] Autor:Krzyzanowska W; Pomierny B; Bystrowska B; Pomierny-Chamiolo L; Filip M; Budziszewska B; Pera J
[Ad] Endereço:Department of Biochemical Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
[Ti] Título:Ceftriaxone- and N-acetylcysteine-induced brain tolerance to ischemia: Influence on glutamate levels in focal cerebral ischemia.
[So] Source:PLoS One;12(10):e0186243, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One of the major players in the pathophysiology of cerebral ischemia is disrupted homeostasis of glutamatergic neurotransmission, resulting in elevated extracellular glutamate (Glu) concentrations and excitotoxicity-related cell death. In the brain, Glu concentrations are regulated by Glu transporters, including Glu transporter-1 (GLT-1) and cystine/Glu antiporter (system xc-). Modulation of these transporters by administration of ceftriaxone (CEF, 200 mg/kg, i.p.) or N-acetylcysteine (NAC, 150 mg/kg, i.p.) for 5 days before focal cerebral ischemia may induce brain tolerance to ischemia by significantly limiting stroke-related damage and normalizing Glu concentrations. In the present study, focal cerebral ischemia was induced by 90-minute middle cerebral artery occlusion (MCAO). We compared the effects of CEF and NAC pretreatment on Glu concentrations in extracellular fluid and cellular-specific expression of GLT-1 and xCT with the effects of two reference preconditioning methods, namely, ischemic preconditioning and chemical preconditioning in rats. Both CEF and NAC significantly reduced Glu levels in the frontal cortex and hippocampus during focal cerebral ischemia, and this decrease was comparable with the Glu level achieved with the reference preconditioning strategies. The results of immunofluorescence staining of GLT-1 and xCT on astrocytes, neurons and microglia accounted for the observed changes in extracellular Glu levels to a certain extent. Briefly, after MCAO, the expression of GLT-1 on astrocytes decreased, but pretreatment with CEF seemed to prevent this downregulation. In addition, every intervention used in this study seemed to reduce xCT expression on astrocytes and neurons. The results of this study indicate that modulation of Glu transporter expression may restore Glu homeostasis. Moreover, our results suggest that CEF and NAC may induce brain tolerance to ischemia by influencing GLT-1 and system xc- expression levels. These transporters are presumably good targets for the development of novel therapies for brain ischemia.
[Mh] Termos MeSH primário: Sistemas de Transporte de Aminoácidos Acídicos/genética
Isquemia Encefálica/tratamento farmacológico
Transportador 2 de Aminoácido Excitatório/genética
Ácido Glutâmico/metabolismo
[Mh] Termos MeSH secundário: Acetilcisteína/administração & dosagem
Animais
Astrócitos/efeitos dos fármacos
Astrócitos/metabolismo
Isquemia Encefálica/genética
Isquemia Encefálica/patologia
Ceftriaxona/administração & dosagem
Lobo Frontal/efeitos dos fármacos
Lobo Frontal/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Seres Humanos
Infarto da Artéria Cerebral Média
Ratos
Transmissão Sináptica/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acid Transport Systems, Acidic); 0 (Excitatory Amino Acid Transporter 2); 0 (Slc1a2 protein, rat); 0 (xCT protein, rat); 3KX376GY7L (Glutamic Acid); 75J73V1629 (Ceftriaxone); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186243


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[PMID]:28934773
[Au] Autor:Benschop J; Collins-Emerson J; Maskill A; O'Connor P; Tunbridge M; Yupiana Y; Weston J
[Ad] Endereço:Co-Director and Senior Lecturer, Molecular Epidemiology and Public Health Laboratory, Institute of Veterinary and Animal Sciences, Massey University, Palmerston North and Global Leptospirosis Environmental Action Network.
[Ti] Título:Leptospirosis in three workers on a dairy farm with unvaccinated cattle.
[So] Source:N Z Med J;130(1462):102-108, 2017 09 22.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:AIM: We report a one-health investigation of three cases of leptospirosis on a dairy farm with unvaccinated cattle in New Zealand. The cases are discussed in the context of diagnostics, risk factors, persistence of symptoms and outbreak mitigation measures. METHOD: Clinical and laboratory records from the human cases were reviewed and serological and molecular investigations were conducted into the Leptospira status of cattle and pigs on the farm. RESULTS: Cases presented early in their illness and all three were confirmed within seven days of onset of symptoms by urine PCR and within 18 days by convalescent MAT (two Hardjo, one Pomona). Cattle and pigs had serological evidence of recent infection with Hardjo/Pomona and Pomona/Copenhageni respectively. Pigs were slaughtered and cattle were vaccinated. Post-exposure prophylaxis was given to staff in-contact with the milking herd until the herd had antibiotic treatment at drying-off (approximately four months after the initial case). CONCLUSION: The utility of PCR testing for Leptospira DNA as both an early and rapid test for leptospirosis was demonstrated. Two of three cases reported persistence of symptoms at least six months after the acute episode and one of these remains unable to work. Risk mitigation measures such as post-exposure prophylaxis, animal vaccination, heightened clinical suspicion of leptospirosis and recognition of context specific risk factors (eg, effluent spreading) demonstrate the value of medical and veterinary experts working together.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Leptospirose/diagnóstico
Leptospirose/tratamento farmacológico
Vacinação/veterinária
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Bovinos/microbiologia
Ceftriaxona/uso terapêutico
Doxiciclina/uso terapêutico
Fazendas
Feminino
Seres Humanos
Leptospira
Masculino
Nova Zelândia
Fatores de Risco
Suínos/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antibodies, Bacterial); 75J73V1629 (Ceftriaxone); N12000U13O (Doxycycline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE


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[PMID]:28853599
[Au] Autor:Hiddema J; Hassan S; Mangat N; Siddiqui N
[Ad] Endereço:Kingston Hospital NHS Foundation Trust , UK.
[Ti] Título:Pyomyositis of the pectineus muscle in an adolescent male.
[So] Source:Ann R Coll Surg Engl;99(7):e216-e218, 2017 Sep.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The 'irritable hip' continues to pose a challenge for clinicians. Even with predictive clinical algorithms, decision making can be difficult. Emergency treatment is required if septic arthritis is suspected. Other differential diagnoses such as transient synovitis, pyomyositis of the pelvic girdle muscles and osteomyelitis must be considered in order to help guide appropriate investigations and allow early treatment. We report the case of a 13-year-old boy presenting to our institution with an acutely painful left hip but still able to weight bear. Despite a fever and raised inflammatory markers, the clinical examination did not correspond to that of an infected hip joint. Urgent magnetic resonance imaging (MRI) confirmed pyomyositis of the pectineus muscle. To our knowledge, this is the first reported case in the literature. The child was treated with seven days of intravenous antibiotics. There was a good clinical response as well as normalisation of the C-reactive protein level and white cell count. The patient was discharged home with a further week of oral antibiotics. Follow-up MRI at two weeks demonstrated a dramatic reduction in the inflammation of the pectineus. At the clinic follow-up appointment, the child was asymptomatic and back to normal function. Pyomyositis is typically found in tropical areas but its rates in temperate climates have been rising. It usually affects large groups of muscles such as the quadriceps and gluteal muscles. MRI is the gold standard investigation. If diagnosed early, the condition can be treated successfully with intravenous antibiotics alone. Given the widespread availability of MRI, we recommend its increased use to distinguish between pyomyositis and other paediatric hip pathologies.
[Mh] Termos MeSH primário: Piomiosite/diagnóstico
Coxa da Perna
[Mh] Termos MeSH secundário: Adolescente
Antibacterianos/uso terapêutico
Ceftriaxona/uso terapêutico
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Músculo Esquelético/diagnóstico por imagem
Piomiosite/diagnóstico por imagem
Piomiosite/tratamento farmacológico
Coxa da Perna/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 75J73V1629 (Ceftriaxone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2017.0142


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[PMID]:28813477
[Au] Autor:Ji W; Zhang L; Guo Z; Xie S; Yang W; Chen J; Wang J; Cheng Z; Wang X; Zhu X; Wang J; Wang H; Huang J; Liang N; McIver DJ
[Ad] Endereço:Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
[Ti] Título:Colonization prevalence and antibiotic susceptibility of Group B Streptococcus in pregnant women over a 6-year period in Dongguan, China.
[So] Source:PLoS One;12(8):e0183083, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the prevalence of recto-vaginal Group B Streptococcus (GBS) colonization, serotype distribution, and antimicrobial susceptibility patterns among pregnant women in Dongguan, China. Recto-vaginal swabs were collected from pregnant women at gestational age 35-37 weeks between January 1st 2009 and December 31st 2014. Isolates were serotyped by latex-agglutination and were tested against seven antimicrobials by disk diffusion. Of 7,726 pregnant women who completed GBS testing, 636 (8.2%) were GBS carriers. Of 153 GBS isolates available for typing, 6 serotypes (Ia, Ib, III, V, VI and VIII) were identified with type III being predominant, while 9 (5.9%) were non-typable isolates. All isolates were sensitive to penicillin, ceftriaxone, linezolid and vancomycin, whereas 52.4% were resistant to clindamycin, 25.9% were resistant to levofloxacin and 64.9% were resistant to erythromycin. This study showed the recto-vaginal colonization prevalence of GBS in Dongguan is significant. Due to 100% susceptibility to penicillin of all GBS samples, penicillin remains the first recommendation for treatment and prevention against GBS infection. Susceptibility testing should be performed for women allergic to penicillin in order to choose the most appropriate antibacterial agents for treatment and prevention of vertical transmission to neonates. In addition, we suggest establishing standard processes for GBS culture and identification in China as early as possible.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Infecções Estreptocócicas/microbiologia
Streptococcus agalactiae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ceftriaxona/farmacologia
China/epidemiologia
Eritromicina/farmacologia
Feminino
Seres Humanos
Linezolida/farmacologia
Testes de Sensibilidade Microbiana
Meia-Idade
Penicilinas/farmacologia
Gravidez
Prevalência
Infecções Estreptocócicas/epidemiologia
Vancomicina/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Penicillins); 63937KV33D (Erythromycin); 6Q205EH1VU (Vancomycin); 75J73V1629 (Ceftriaxone); ISQ9I6J12J (Linezolid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183083


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[PMID]:28749999
[Au] Autor:Verdino A; Vigliotta G; Giordano D; Caputo I; Soriente A; De Rosa M; Marabotti A
[Ad] Endereço:Department of Chemistry and Biology "A. Zambelli", University of Salerno, Fisciano (SA), Italy.
[Ti] Título:Synthesis and biological evaluation of the progenitor of a new class of cephalosporin analogues, with a particular focus on structure-based computational analysis.
[So] Source:PLoS One;12(7):e0181563, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present the synthesis and biological evaluation of the prototype of a new class of cephalosporins, containing an additional isolated beta lactam ring with two phenyl substituents. This new compound is effective against Gram positive microorganisms, with a potency similar to that of ceftriaxone, a cephalosporin widely used in clinics and taken as a reference, and with no cytotoxicity against two different human cell lines, even at a concentration much higher than the minimal inhibitory concentration tested. Additionally, a deep computational analysis has been conducted with the aim of understanding the contribution of its moieties to the binding energy towards several penicillin-binding proteins from both Gram positive and Gram negative bacteria. All these results will help us developing derivatives of this compound with improved chemical and biological properties, such as a broader spectrum of action and/or an increased affinity towards their molecular targets.
[Mh] Termos MeSH primário: Cefalosporinas/química
Cefalosporinas/síntese química
Modelos Moleculares
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Ceftriaxona/síntese química
Ceftriaxona/química
Ceftriaxona/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Cefalosporinas/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Células Hep G2
Seres Humanos
Testes de Sensibilidade Microbiana
Simulação de Acoplamento Molecular
Proteínas de Ligação às Penicilinas/farmacologia
Relação Estrutura-Atividade
beta-Lactamas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (Penicillin-Binding Proteins); 0 (beta-Lactams); 75J73V1629 (Ceftriaxone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181563


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[PMID]:28711274
[Au] Autor:Patel K; Shah S; Subedi D
[Ad] Endereço:Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, United States. Electronic address: patelki@upstate.edu.
[Ti] Título:Clinical association: Lyme disease and Guillain-Barre syndrome.
[So] Source:Am J Emerg Med;35(10):1583.e1-1583.e2, 2017 Oct.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Guillain-Barre Syndrome (GBS) is a life-threatening condition in which patients may present to the Emergency Department in respiratory distress leading to death. The early identification and treatment of such a condition is paramount in preventing mortality. While there are many infections associated with GBS, the association with Lyme disease is uncommon. Through our case we aim to highlight Borrelia burgdorferi as an important antecedent infection associated with the development of GBS. In this case we report a 31-year-old male who was diagnosed with Lyme disease and GBS with relevant clinical presentation including progressive numbness and weakness in bilateral hands and feet for the past 1week along with areflexia. Initiation of medical therapy with intravenous immunoglobulin and parenteral ceftriaxone resulted in resolution of his symptoms. The treatment of both diseases early can help prevent further central nervous complications leading to high morbidity and mortality.
[Mh] Termos MeSH primário: Síndrome de Guillain-Barré/complicações
Doença de Lyme/complicações
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/administração & dosagem
Ceftriaxona/administração & dosagem
Quimioterapia Combinada
Eletromiografia
Síndrome de Guillain-Barré/diagnóstico
Síndrome de Guillain-Barré/tratamento farmacológico
Seres Humanos
Imunoglobulinas Intravenosas/administração & dosagem
Fatores Imunológicos/administração & dosagem
Injeções Intravenosas
Doença de Lyme/diagnóstico
Doença de Lyme/tratamento farmacológico
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Immunoglobulins, Intravenous); 0 (Immunologic Factors); 75J73V1629 (Ceftriaxone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE



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