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  1 / 1988 MEDLINE  
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[PMID]:28975304
[Au] Autor:Valent AM; DeArmond C; Houston JM; Reddy S; Masters HR; Gold A; Boldt M; DeFranco E; Evans AT; Warshak CR
[Ad] Endereço:Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland.
[Ti] Título:Effect of Post-Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women: A Randomized Clinical Trial.
[So] Source:JAMA;318(11):1026-1034, 2017 09 19.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: The rate of obesity among US women has been increasing, and obesity is associated with increased risk of surgical site infection (SSI) following cesarean delivery. The optimal perioperative antibiotic prophylactic regimen in this high-risk population undergoing cesarean delivery is unknown. Objective: To determine rates of SSI among obese women who receive prophylactic oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery. Design, Setting, and Participants: Randomized, double-blind clinical trial comparing oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery for the prevention of SSI in obese women (prepregnancy BMI ≥30) who had received standard intravenous preoperative cephalosporin prophylaxis. Randomization was stratified by intact vs rupture of membranes prior to delivery. The study was conducted at the University of Cincinnati Medical Center, Cincinnati, Ohio, an academic and urban setting, between October 2010 and December 2015, with final follow-up through February 2016. Interventions: Participants were randomly assigned to receive oral cephalexin, 500 mg, and metronidazole, 500 mg (n = 202 participants), vs identical-appearing placebo (n = 201 participants) every 8 hours for a total of 48 hours following cesarean delivery. Main Outcomes and Measures: The primary outcome was SSI, defined as any superficial incisional, deep incisional, or organ/space infections within 30 days after cesarean delivery. Results: Among 403 randomized participants who were included (mean age, 28 [SD, 6] years; mean BMI, 39.7 [SD, 7.8]), 382 (94.6%) completed the trial. The overall rate of SSI was 10.9% (95% CI, 7.9%-14.0%). Surgical site infection was diagnosed in 13 women (6.4%) in the cephalexin-metronidazole group vs 31 women (15.4%) in the placebo group (difference, 9.0% [95% CI, 2.9%-15.0%]; relative risk, 0.41 [95% CI, 0.22-0.77]; P = .01). There were no serious adverse events, including allergic reaction, reported in either the antibiotic group or the placebo group. Conclusions and Relevance: Among obese women undergoing cesarean delivery who received the standard preoperative cephalosporin prophylaxis, a postoperative 48-hour course of oral cephalexin and metronidazole, compared with placebo, reduced the rate of SSI within 30 days after delivery. For prevention of SSI among obese women after cesarean delivery, prophylactic oral cephalexin and metronidazole may be warranted. Trial Registration: clinicaltrials.gov Identifier: NCT01194115.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Antibioticoprofilaxia
Cefalexina/uso terapêutico
Cesárea/efeitos adversos
Obesidade/complicações
Infecção da Ferida Cirúrgica/prevenção & controle
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Seres Humanos
Metronidazol/uso terapêutico
Cuidados Pós-Operatórios
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 140QMO216E (Metronidazole); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10567


  2 / 1988 MEDLINE  
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[PMID]:28599150
[Au] Autor:Meng LW; Li XK; Wang ST; Liu LL; Ma KL; Zhang J
[Ad] Endereço:School of Municipal and Environmental Engineering, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
[Ti] Título:The long-term impact of cefalexin on organic substrate degradation and microbial community structure in EGSB system.
[So] Source:Chemosphere;184:215-223, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In order to investigate long-term effect of cefalexin (CFX) on the performance of expanded granular sludge bed (EGSB) system and microbial community structure, two 1.47 L EGSB reactors E1 and E2 were designed and run for 224 days treating with synthetic antibiotic wastewater. For the purpose of comparison, E1 was fed with synthetic antibiotic industry wastewater with CFX added as the test reactor, while, E2 was fed without any CFX added as the control reactor (E2). The addition of CFX resulted in the continual increasing of soluble COD (sCOD) and accumulation of VFAs in the effluent of E1 system. Besides, it was found that the accumulation of CFX by-products D-1, D-2 and D-3 was negative correlation with sCOD removal efficiency. Furthermore, the microbial community structures were also investigated. For the bacterial community, Gelria and Syntrophorhabdus which can ferment propionate and other organic pollutants as their substrate were obviously enriched in E1 system. For the archaea, there was more functional diversity in E1 system than in E2 system. Furthermore, fungi also played an important role on the removal of complex organics in E1 system.
[Mh] Termos MeSH primário: Antibacterianos/análise
Biodegradação Ambiental/efeitos dos fármacos
Cefalexina/análise
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Antibacterianos/toxicidade
Archaea
Reatores Biológicos/microbiologia
Cefalexina/toxicidade
Esgotos/química
Águas Residuais
Microbiologia da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Sewage); 0 (Waste Water); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


  3 / 1988 MEDLINE  
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[PMID]:28535235
[Au] Autor:Moran GJ; Krishnadasan A; Mower WR; Abrahamian FM; LoVecchio F; Steele MT; Rothman RE; Karras DJ; Hoagland R; Pettibone S; Talan DA
[Ad] Endereço:Department of Emergency Medicine, Olive View-UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California2Division of Infectious Diseases, Department of Medicine, Olive View-UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California.
[Ti] Título:Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial.
[So] Source:JAMA;317(20):2088-2096, 2017 May 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Emergency department visits for skin infections in the United States have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). For cellulitis without purulent drainage, ß-hemolytic streptococci are presumed to be the predominant pathogens. It is unknown if antimicrobial regimens possessing in vitro MRSA activity provide improved outcomes compared with treatments lacking MRSA activity. Objective: To determine whether cephalexin plus trimethoprim-sulfamethoxazole yields a higher clinical cure rate of uncomplicated cellulitis than cephalexin alone. Design, Setting, and Participants: Multicenter, double-blind, randomized superiority trial in 5 US emergency departments among outpatients older than 12 years with cellulitis and no wound, purulent drainage, or abscess enrolled from April 2009 through June 2012. All participants had soft tissue ultrasound performed at the time of enrollment to exclude abscess. Final follow-up was August 2012. Interventions: Cephalexin, 500 mg 4 times daily, plus trimethoprim-sulfamethoxazole, 320 mg/1600 mg twice daily, for 7 days (n = 248 participants) or cephalexin plus placebo for 7 days (n = 248 participants). Main Outcomes and Measures: The primary outcome determined a priori in the per-protocol group was clinical cure, defined as absence of these clinical failure criteria at follow-up visits: fever; increase in erythema (>25%), swelling, or tenderness (days 3-4); no decrease in erythema, swelling, or tenderness (days 8-10); and more than minimal erythema, swelling, or tenderness (days 14-21). A clinically significant difference was defined as greater than 10%. Results: Among 500 randomized participants, 496 (99%) were included in the modified intention-to-treat analysis and 411 (82.2%) in the per-protocol analysis (median age, 40 years [range, 15-78 years]; 58.4% male; 10.9% had diabetes). Median length and width of erythema were 13.0 cm and 10.0 cm. In the per-protocol population, clinical cure occurred in 182 (83.5%) of 218 participants in the cephalexin plus trimethoprim-sulfamethoxazole group vs 165 (85.5%) of 193 in the cephalexin group (difference, -2.0%; 95% CI, -9.7% to 5.7%; P = .50). In the modified intention-to-treat population, clinical cure occurred in 189 (76.2%) of 248 participants in the cephalexin plus trimethoprim-sulfamethoxazole group vs 171 (69.0%) of 248 in the cephalexin group (difference, 7.3%; 95% CI, -1.0% to 15.5%; P = .07). Between-group adverse event rates and secondary outcomes through 7 to 9 weeks, including overnight hospitalization, recurrent skin infections, and similar infection in household contacts, did not differ significantly. Conclusions and Relevance: Among patients with uncomplicated cellulitis, the use of cephalexin plus trimethoprim-sulfamethoxazole compared to cephalexin alone did not result in higher rates of clinical resolution of cellulitis in the per-protocol analysis. However, because imprecision around the findings in the modified intention-to-treat analysis included a clinically important difference favoring cephalexin plus trimethoprim-sulfamethoxazole, further research may be needed. Trial Registration: clinicaltrials.gov Identifier: NCT00729937.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Celulite (Flegmão)/tratamento farmacológico
Cefalexina/uso terapêutico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antibacterianos/efeitos adversos
Cefalexina/efeitos adversos
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Seres Humanos
Análise de Intenção de Tratamento
Masculino
Staphylococcus aureus Resistente à Meticilina
Meia-Idade
Infecções Estafilocócicas/tratamento farmacológico
Resultado do Tratamento
Combinação Trimetoprima e Sulfametoxazol/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.5653


  4 / 1988 MEDLINE  
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[PMID]:28432369
[Au] Autor:Mortazavi SMJ; Zarei S; Taheri M; Tajbakhsh S; Mortazavi SA; Ranjbar S; Momeni F; Masoomi S; Ansari L; Movahedi MM; Taeb S; Zarei S; Haghani M
[Ad] Endereço:Department of Diagnostic Imaging, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA. mmortazavi@sums.ac.ir.
[Ti] Título:Sensitivity to Antibiotics of Bacteria Exposed to Gamma Radiation Emitted from Hot Soils of the High Background Radiation Areas of Ramsar, Northern Iran.
[So] Source:Int J Occup Environ Med;8(2):80-84, 2017 04.
[Is] ISSN:2008-6814
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Over the past several years our laboratories have investigated different aspects of the challenging issue of the alterations in bacterial susceptibility to antibiotics induced by physical stresses. OBJECTIVE: To explore the bacterial susceptibility to antibiotics in samples of subsp. serovar Typhimurium ( ), , and after exposure to gamma radiation emitted from the soil samples taken from the high background radiation areas of Ramsar, northern Iran. METHODS: Standard Kirby-Bauer test, which evaluates the size of the zone of inhibition as an indicator of the susceptibility of different bacteria to antibiotics, was used in this study. RESULTS: The maximum alteration of the diameter of inhibition zone was found for when tested for ciprofloxacin. In this case, the mean diameter of no growth zone in non-irradiated control samples of was 20.3 (SD 0.6) mm; it was 14.7 (SD 0.6) mm in irradiated samples. On the other hand, the minimum changes in the diameter of inhibition zone were found for and when these bacteria were tested for nitrofurantoin and cephalexin, respectively. CONCLUSION: Gamma rays were capable of making significant alterations in bacterial susceptibility to antibiotics. It can be hypothesized that high levels of natural background radiation can induce adaptive phenomena that help microorganisms better cope with lethal effects of antibiotics.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana/efeitos da radiação
Raios gama
Klebsiella pneumoniae/efeitos dos fármacos
Salmonella typhimurium/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Radiação de Fundo
Cefalexina/farmacologia
Ciprofloxacino/farmacologia
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Irã (Geográfico)
Klebsiella pneumoniae/efeitos da radiação
Nitrofurantoína/farmacologia
Salmonella typhimurium/efeitos da radiação
Solo
Staphylococcus aureus/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Soil); 5E8K9I0O4U (Ciprofloxacin); 927AH8112L (Nitrofurantoin); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.15171/ijoem.2017.958


  5 / 1988 MEDLINE  
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[PMID]:28373731
[Au] Autor:Larouche CB; Desmarchelier MR; Specchi S; Langlois I
[Ad] Endereço:Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec J2S 7C6.
[Ti] Título:Pneumatosis coli in a domestic ferret .
[So] Source:Can Vet J;58(4):383-386, 2017 Apr.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:A 4-year-old spayed female ferret was presented with acute diarrhea and partial anorexia. Pneumatosis coli and segmental enteropathy were identified by ultrasonography and radiography. Fecal culture did not identify any pathogenic bacteria. Medical management of concurrent diseases and antibiotic therapy resulted in resolution of clinical signs and pneumatosis coli.
[Mh] Termos MeSH primário: Pneumatose Cistoide Intestinal/veterinária
[Mh] Termos MeSH secundário: Animais
Antibacterianos/administração & dosagem
Cefalexina/administração & dosagem
Enterite/diagnóstico por imagem
Enterite/tratamento farmacológico
Enterite/veterinária
Feminino
Furões
Pneumatose Cistoide Intestinal/diagnóstico por imagem
Pneumatose Cistoide Intestinal/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


  6 / 1988 MEDLINE  
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[PMID]:28334649
[Au] Autor:Chen X; Li Y; Zhang Y; Yang J; Bian L
[Ad] Endereço:College of Life Science, Northwest University, Xi'an 710069, PR China.
[Ti] Título:Binding of TEM-1 beta-lactamase to beta-lactam antibiotics by frontal affinity chromatography.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1051:75-83, 2017 Apr 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:TEM-1 beta-lactamases can accurately catalyze the hydrolysis of the beta-lactam rings in beta-lactam antibiotics, which make beta-lactam antibiotics lose its activity, and the prerequisite for the hydrolysis procedure in the binding interaction of TEM-1 beta-lactamases with beta-lactam antibiotics is the beta-lactam rings in beta-lactam antibiotics. Therefore, the binding of TEM-1 beta-lactamase to three beta-lactam antibiotics including penicillin G, cefalexin as well as cefoxitin was explored here by frontal affinity chromatography in combination with fluorescence spectra, adsorption and thermodynamic data in the temperature range of 278-288K under simulated physiological conditions. The results showed that all the binding of TEM-1 beta-lactamase to the three antibiotics were spontaneously exothermic processes with the binding constants of 8.718×10 , 6.624×10 and 2.244×10 (mol/L), respectively at 288K. All the TEM-1 beta-lactamases were immobilized on the surface of the stationary phase in the mode of monolayer and there existed only one type of binding sites on them. Each TEM-1 beta-lactamase bound with only one beta-lactam antibiotic and hydrogen bond interaction and Van der Waals force were the main forces between them. This work provided an insight into the binding interactions between TEM-1 beta-lactamases and beta-lactam antibiotics, which may be beneficial for the designing and developing of new substrates resistant to TEM-1 beta-lactamases.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Cromatografia de Afinidade/métodos
Bactérias Gram-Negativas/enzimologia
beta-Lactamases/metabolismo
beta-Lactamas/metabolismo
[Mh] Termos MeSH secundário: Cefoxitina/metabolismo
Cefalexina/metabolismo
Enzimas Imobilizadas/metabolismo
Bactérias Gram-Negativas/metabolismo
Penicilina G/metabolismo
Ligação Proteica
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Enzymes, Immobilized); 0 (beta-Lactams); 6OEV9DX57Y (Cefoxitin); EC 3.5.2.6 (beta-Lactamases); EC 3.5.2.6 (beta-lactamase TEM-1); OBN7UDS42Y (Cephalexin); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE


  7 / 1988 MEDLINE  
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[PMID]:28187247
[Au] Autor:Barber DA; Casquejo E; Ybañez PL; Pinote MT; Casquejo L; Pinote LS; Estorgio M; Young AM
[Ad] Endereço:Department of Epidemiology, University of Kentucky, Lexington, KY, USA.
[Ti] Título:Prevalence and correlates of antibiotic sharing in the Philippines: antibiotic misconceptions and community-level access to non-medical sources of antibiotics.
[So] Source:Trop Med Int Health;22(5):567-575, 2017 May.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To identify sociodemographic, knowledge and attitudinal correlates to antibiotic sharing among a community-based sample of adults (age 18 and older) in a low-income setting of the Philippines and to explore community-level data on informal antibiotic distribution in roadside stands (i.e., sari-sari stands). METHODS: Participants (n = 307) completed self-administered surveys. Correlates to antibiotic sharing were assessed using logistic regression with Firth's bias-adjusted estimates. Study staff also visited 106 roadside stands and collected data on availability and characteristics of antibiotics in the stands. RESULTS: 78% had shared antibiotics in their lifetime, most often with family members. In multivariable analysis, agreement with the belief that it is safe to prematurely stop an antibiotic course (OR: 2.8, CI: 1.3-5.8) and concerns about antibiotic side effects (OR: 2.1, CI: 1.1-4.4) were significantly associated with increased odds of reported antibiotic sharing. Antibiotic sharing was not associated with sociodemographic characteristics or antibiotic knowledge. Antibiotics were widely available in 60% of sampled sari-sari stands, in which 59% of antibiotics were missing expiration dates. Amoxicillin and cephalexin were the most commonly available antibiotics for sale at the stands (60% and 21%, respectively). CONCLUSIONS: Antibiotic sharing was common and was associated with misconceptions about proper antibiotic use. Antibiotics were widely available in sari-sari stands, and usually without expiration information. This study suggests that multipronged and locally tailored approaches to curbing informal antibiotic access are needed in the Philippines and similar Southeast-Asian countries.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Conhecimentos, Atitudes e Prática em Saúde
Conhecimento do Paciente sobre a Medicação
Medicamentos sob Prescrição/uso terapêutico
Distribuição Espacial da População
Automedicação
Comportamento Social
[Mh] Termos MeSH secundário: Adulto
Amoxicilina
Cefalexina
Comércio
Prescrições de Medicamentos
Família
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Filipinas
Pobreza
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Prescription Drugs); 804826J2HU (Amoxicillin); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12854


  8 / 1988 MEDLINE  
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[PMID]:28042159
[Au] Autor:Fungwithaya P; Chanchaithong P; Phumthanakorn N; Prapasarakul N
[Ad] Endereço:Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
[Ti] Título:Nasal carriage of methicillin-resistant in dogs treated with cephalexin monohydrate.
[So] Source:Can Vet J;58(1):73-77, 2017 Jan.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:This study aimed to investigate the nasal carriage of methicillin-resistant (MRSP) in dogs treated with oral cephalexin monohydrate. Ten dogs with superficial pyoderma were monitored longitudinally for carriage of MRSP for up to 1 year after treatment; the strains were typed and antibiograms were determined. Methicillin-susceptible (MSSP) was recovered prior to treatment in all dogs and could be isolated after 12 months in 1 dog. Methicillin-resistant was detected within 1 week of treatment in all dogs, and 3 clones represented by ST45, ST112, and ST181 were consistently present for up to 12 months after treatment. All MRSP isolates were resistant to at least 7 common antimicrobials. Oral cephalexin monohydrate treatment selected for strains of multi-resistant MRSP, which were still present after 1 year.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Cefalexina/uso terapêutico
Doenças do Cão/microbiologia
Resistência a Meticilina
Nariz/microbiologia
Staphylococcus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/tratamento farmacológico
Cães
Feminino
Masculino
Staphylococcus/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


  9 / 1988 MEDLINE  
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[PMID]:27847122
[Au] Autor:Coledam DA; Pupo MM; Silva BF; Silva AJ; Eguiluz KI; Salazar-Banda GR; Aquino JM
[Ad] Endereço:Departamento de Química, Universidade Federal de São Carlos, C.P. 676, 13560-970 São Carlos, SP, Brazil.
[Ti] Título:Electrochemical mineralization of cephalexin using a conductive diamond anode: A mechanistic and toxicity investigation.
[So] Source:Chemosphere;168:638-647, 2017 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The contamination of surface and ground water by antibiotics is of significant importance due to their potential chronic toxic effects to the aquatic and human lives. Thus, in this work, the electrochemical oxidation of cephalexin (CEX) was carried out in a one compartment filter-press flow cell using a boron-doped diamond (BDD) electrode as anode. During the electrolysis, the investigated variables were: supporting electrolyte (Na SO , NaCl, NaNO , and Na CO ) at constant ionic strength (0.1 M), pH (3, 7, 10, and without control), and current density (5, 10 and 20 mA cm ). The oxidation and mineralization of CEX were assessed by high performance liquid chromatography, coupled to mass spectrometry and total organic carbon. The oxidation process of CEX was dependent on the type of electrolyte and on pH of the solution due to the distinct oxidant species electrogenerated; however, the conversion of CEX and its hydroxylated intermediates to CO depends only on their diffusion to the surface of the BDD. In the final stages of electrolysis, an accumulation of recalcitrant oxamic and oxalic carboxylic acids, was detected. Finally, the growth inhibition assay with Escherichia coli cells showed that the toxicity of CEX solution decreased along the electrochemical treatment due to the rupture of the ß-lactam ring of the antibiotic.
[Mh] Termos MeSH primário: Cefalexina
Diamante/química
Técnicas Eletroquímicas/métodos
Poluentes Químicos da Água
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Boro/química
Dióxido de Carbono/análise
Ácidos Carboxílicos/análise
Cefalexina/análise
Cefalexina/toxicidade
Cromatografia Líquida de Alta Pressão
Técnicas Eletroquímicas/instrumentação
Eletrodos
Eletrólise
Escherichia coli/efeitos dos fármacos
Oxirredução
Espectrometria de Massas em Tandem
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/toxicidade
Purificação da Água/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Water Pollutants, Chemical); 142M471B3J (Carbon Dioxide); 7782-40-3 (Diamond); N9E3X5056Q (Boron); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE


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[PMID]:27789268
[Au] Autor:Davis CM; Gregoire CE; Davis I; Steeves TW
[Ad] Endereço:Resident, Department of Oral and Maxillofacial Surgery, Dalhousie University and Nova Scotia Health Authority, Halifax, NS, Canada. Electronic address: cdavis.omfs@gmail.com.
[Ti] Título:Prevalence of Surgical Site Infections Following Orthognathic Surgery: A Double-Blind, Randomized Controlled Trial on a 3-Day Versus 1-Day Postoperative Antibiotic Regimen.
[So] Source:J Oral Maxillofac Surg;75(4):796-804, 2017 Apr.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to determine the effect of a 3- versus 1-day antibiotic regimen on the rate of surgical site infection (SSI) in patients undergoing orthognathic surgery at a department of oral and maxillofacial surgery in Halifax, Nova Scotia, Canada. MATERIALS AND METHODS: A prospective, randomized controlled trial was conducted. All patients received 1 day of intravenous antibiotics after surgery. Then, patients were randomly distributed into groups that received 2 days of additional antibiotics (group A) or placebo (group B). The primary outcome measured was the presence of SSI. The operating surgeon, concomitant extraction of teeth, surgical procedures performed, duration of intermaxillary fixation, and length of hospital stay were analyzed for an effect on SSI. Patients were followed for 1 year after surgery to identify SSIs that might have been diagnosed outside the hospital. RESULTS: The trial started with 288 patients, and 117 patients were lost to follow-up. Statistical analyses were ultimately performed on those 171 patients who were adherent to the study medication regimen. Group A (n = 86) and B (n = 85) SSI rates were 7.0 and 17.6% (number needed to treat = 10; P = .04), respectively. Mandibular bilateral sagittal split osteotomy (BSSO) was involved in 71% of SSIs. Intra- and postoperative surgical variables did not have a relevant effect on the SSI rate. Patients were followed for 1 year after surgery, and group A (n = 46) and group B (n = 44) had SSI rates of 4 and 25% (P < .05), respectively. CONCLUSIONS: Three days of postoperative cefazolin and cephalexin markedly decreases SSI rates compared with 1 day. However, the number needed to treat of 10 suggests that the benefits of the extended regimen might not outweigh the risks. The high prevalence of SSIs at the mandibular BSSO incisions might have been caused by contamination, with more saliva and reception of a lower blood supply, than maxillary Le Fort I incisions. Mandibular osteotomies could benefit from an extended antibiotic regimen to minimize SSIs and associated complications. Other surgical variables might not require special consideration for antibiotic therapy.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Cefazolina/uso terapêutico
Cefalexina/uso terapêutico
Clindamicina/uso terapêutico
Procedimentos Cirúrgicos Ortognáticos
Infecção da Ferida Cirúrgica/tratamento farmacológico
Infecção da Ferida Cirúrgica/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antibacterianos/administração & dosagem
Cefazolina/administração & dosagem
Cefalexina/administração & dosagem
Clindamicina/administração & dosagem
Método Duplo-Cego
Feminino
Seres Humanos
Tempo de Internação/estatística & dados numéricos
Masculino
Meia-Idade
Prevalência
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 3U02EL437C (Clindamycin); IHS69L0Y4T (Cefazolin); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE



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