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[PMID]:28988110
[Au] Autor:Fadel MA; El-Gebaly RH; Mohamed SA; Abdelbacki AMM
[Ad] Endereço:Biophysics Department, Faculty of Science, Cairo University, Egypt.
[Ti] Título:Biophysical control of the growth of Agrobacterium tumefaciens using extremely low frequency electromagnetic waves at resonance frequency.
[So] Source:Biochem Biophys Res Commun;494(1-2):365-371, 2017 Dec 09.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isolated Agrobacterium tumefaciens was exposed to different extremely low frequencies of square amplitude modulated waves (QAMW) from two generators to determine the resonance frequency that causes growth inhibition. The carrier was 10 MHz sine wave with amplitude ±10 Vpp which was modulated by a second wave generator with a modulation depth of ± 2Vpp and constant field strength of 200 V/m at 28 °C. The exposure of A. tumefaciens to 1.0 Hz QAMW for 90 min inhibited the bacterial growth by 49.2%. In addition, the tested antibiotics became more effective against A. tumefaciens after the exposure. Furthermore, results of DNA, dielectric relaxation and TEM showed highly significant molecular and morphological changes due to the exposure to 1.0 Hz QAMW for 90 min. An in-vivo study has been carried out on healthy tomato plants to test the pathogenicity of A. tumefaciens before and after the exposure to QAMW at the inhibiting frequency. Symptoms of crown gall and all pathological symptoms were more aggressive in tomato plants treated with non-exposed bacteria, comparing with those treated with exposed bacteria. We concluded that, the exposure of A. tumefaciens to 1.0 Hz QAMW for 90 min modified its cellular activity and DNA structure, which inhibited the growth and affected the microbe pathogenicity.
[Mh] Termos MeSH primário: Agrobacterium tumefaciens/efeitos da radiação
Antibacterianos/farmacologia
DNA Bacteriano/efeitos da radiação
Radiação Eletromagnética
[Mh] Termos MeSH secundário: Agrobacterium tumefaciens/efeitos dos fármacos
Agrobacterium tumefaciens/genética
Agrobacterium tumefaciens/crescimento & desenvolvimento
Amicacina/farmacologia
Carbenicilina/farmacologia
Cefaclor/farmacologia
Cloranfenicol/farmacologia
Ciprofloxacino/farmacologia
DNA Bacteriano/efeitos dos fármacos
Fluoroquinolonas/farmacologia
Gentamicinas/farmacologia
Lycopersicon esculentum/microbiologia
Tumores de Planta/microbiologia
Rifampina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Fluoroquinolones); 0 (Gentamicins); 5E8K9I0O4U (Ciprofloxacin); 66974FR9Q1 (Chloramphenicol); 69K7K19H4L (Cefaclor); 84319SGC3C (Amikacin); G42ZU72N5G (Carbenicillin); L4618BD7KJ (gatifloxacin); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


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[PMID]:28415948
[Au] Autor:Alagl A; Bedi S; Hassan K; AlHumaid J
[Ad] Endereço:1 Division of Periodontics, Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam, Saudi Arabia.
[Ti] Título:Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation.
[So] Source:J Int Med Res;45(2):583-593, 2017 Apr.
[Is] ISSN:1473-2300
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective This study was performed to assess the clinical and radiological outcomes of a revascularization procedure in immature teeth with apical periodontitis using platelet-rich plasma (PRP). The PRP protocol and conventional revascularization protocol, which used a blood clot as the scaffold, were compared. Methods Thirty non-vital immature permanent teeth were randomly categorized into two groups. After disinfecting the root canal space with triple antibiotic paste (1:1:1 ciprofloxacin, metronidazole, and cefaclor), a tissue scaffold was created using either PRP or a blood clot (control) and covered with white mineral trioxide aggregate. All cases were followed up clinically and radiographically for 12 months. Differences in bone density, root length, and lesion size were calculated using preoperative and postoperative computed tomography images. The means of the differences in individual parameters in the blood clot and PRP groups were compared using the Mann-Whitney U test. Results After 5 months, sensitivity tests (cold and electric pulp tests) elicited a delayed positive response in 23 sites. At 12 months, cone-beam computed tomography revealed resolution or a decrease in lesion size and an increase in bone density in all 30 (100%) teeth. Additionally, continued root development was observed in 22 (73%) teeth and early root growth was observed in the test group (mineral trioxide aggregate with PRP). Conclusions The results of this study suggest that PRP can serve as a successful scaffold for regenerative endodontic treatment. With the exception of a significant increase in root length, the results of treatment with PRP were not significantly different from those of the conventional protocol using a blood clot as the scaffold.
[Mh] Termos MeSH primário: Neovascularização Fisiológica
Periodontite Periapical/cirurgia
Plasma Rico em Plaquetas/química
Regeneração/fisiologia
Trombose/metabolismo
Raiz Dentária/cirurgia
[Mh] Termos MeSH secundário: Compostos de Alumínio/uso terapêutico
Antibacterianos/farmacologia
Densidade Óssea/efeitos dos fármacos
Compostos de Cálcio/uso terapêutico
Cefaclor/farmacologia
Criança
Ciprofloxacino/farmacologia
Tomografia Computadorizada de Feixe Cônico
Cimentos Dentários/uso terapêutico
Combinação de Medicamentos
Feminino
Seguimentos
Seres Humanos
Masculino
Metronidazol/farmacologia
Óxidos/uso terapêutico
Periodontite Periapical/diagnóstico por imagem
Periodontite Periapical/patologia
Silicatos/uso terapêutico
Tecidos Suporte
Raiz Dentária/irrigação sanguínea
Raiz Dentária/diagnóstico por imagem
Raiz Dentária/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Compounds); 0 (Anti-Bacterial Agents); 0 (Calcium Compounds); 0 (Dental Cements); 0 (Drug Combinations); 0 (Oxides); 0 (Silicates); 0 (mineral trioxide aggregate); 140QMO216E (Metronidazole); 5E8K9I0O4U (Ciprofloxacin); 69K7K19H4L (Cefaclor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1177/0300060517692935


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[PMID]:27457111
[Au] Autor:Price JR; Guran LA; Gregory WT; McDonagh MS
[Ad] Endereço:Division of Urogynecology and Reconstructive Pelvic Surgery, Oregon Health and Science University, Portland, OR. Electronic address: jamecap@hotmail.com.
[Ti] Título:Nitrofurantoin vs other prophylactic agents in reducing recurrent urinary tract infections in adult women: a systematic review and meta-analysis.
[So] Source:Am J Obstet Gynecol;215(5):548-560, 2016 Nov.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The clinical and financial burden from bladder infections is significant. Daily antibiotic use is the recommended strategy for recurrent urinary tract infection prevention. Increasing antibiotic resistance rates, however, require immediate identification of innovative alternative prophylactic therapies. This systematic review aims to provide guidance on gaps in evidence to guide future research. OBJECTIVE: The objective of this review was to provide current pooled estimates of randomized control trials comparing the effects of nitrofurantoin vs other agents in reducing recurrent urinary tract infections in adult, nonpregnant women and assess relative adverse side effects. DATA SOURCES: Data sources included the following: MEDLINE, Jan. 1, 1946, to Jan. 31, 2015; Cochrane Central Register of Controlled Trials the Cochrane Database of Systematic Reviews, and web sites of the National Institute for Clinical Excellence, and the National Guideline Clearinghouse from 2000 to 2015. Randomized control trials of women with recurrent urinary tract infections comparing nitrofurantoin with any other treatment were included. STUDY DESIGN: A protocol for the study was developed a priori. Published guidance was followed for assessment of study quality. All meta-analyses were performed using random-effects models with Stats Direct Software. Dual review was used for all decisions and data abstraction. RESULTS: Twelve randomized control trials involving 1063 patients were included. One study that had a serious flaw was rated poor in quality, one study rated good, and the remainder fair. No significant differences in prophylactic antibiotic treatment with nitrofurantoin and norfloxacin, trimethoprim, sulfamethoxazole/trimethoprim, methamine hippurate, estriol, or cefaclor were found in clinical or microbiological cure in adult nonpregnant women with recurrent urinary tract infections (9 randomized control trials, 673 patients, relative risk ratio, 1.06; 95% confidence interval, 0.89-1.27; I , 65%; and 12 randomized control trials, 1063 patients, relative risk ratio, 1.06; 95% confidence interval, 0.90-1.26; I , 76%, respectively). Duration of prophylaxis also did not have a significant impact on outcomes. There was a statistically significant difference in overall adverse effects, with nitrofurantoin resulting in greater risk than other prophylactic treatments (10 randomized control trials, 948 patients, relative risk ratio, 2.17; 95% confidence interval, 1.34-3.50; I , 61%). Overall, the majority of nitrofurantoin adverse effects were gastrointestinal, with a significant difference for withdrawals (12 randomized control trials, 1063 patients, relative risk ratio, 2.14; 95% confidence interval, 1.28-3.56; I , 8%). CONCLUSION: Nitrofurantoin had similar efficacy but a greater risk of adverse events than other prophylactic treatments. Balancing the risks of adverse events, particularly gastrointestinal symptoms, with potential benefits of decreasing collateral ecological damage should be considered if selecting nitrofurantoin.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Anti-Infecciosos Urinários/uso terapêutico
Nitrofurantoína/uso terapêutico
Infecções Urinárias/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Cefaclor/uso terapêutico
Estriol/uso terapêutico
Feminino
Seres Humanos
Norfloxacino/uso terapêutico
Recidiva
Prevenção Secundária
Trimetoprima/uso terapêutico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Urinary); 69K7K19H4L (Cefaclor); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); 927AH8112L (Nitrofurantoin); AN164J8Y0X (Trimethoprim); FB33469R8E (Estriol); N0F8P22L1P (Norfloxacin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE


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[PMID]:26886327
[Au] Autor:Tomic Z; Tomas A; Vukmirovic S; Mikov M; Horvat O; Tomic N; Sabo A
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Medicine Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia.
[Ti] Título:Do We Bury Antibacterials When Launching? Cefaclor Example.
[So] Source:J Pharm Sci;105(3):1295-300, 2016 Mar.
[Is] ISSN:1520-6017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to compare existing dosing regimens of cefaclor with recommended pharmacokinetic/pharmacodynamic (PK/PD) parameters and to see if the proposed dosing regimen could have been the reason for development of bacterial resistance. PKs of cefaclor were determined after administrating the highest therapeutic dose of 750 mg in standard release (SF) and modified release form (MRF) in 12 volunteers. The study was performed on clinical isolates of the most frequent causative agents in urinary and respiratory infections. Minimum inhibitory concentration (MIC), postantibiotic effect, and PK/PD efficacy indices were determined. Peak plasma concentrations of 23.142 ± 5.67 (SF) and 8.7 ± 2.09 µg/mL (MRF) were observed after 40-60 min and 3.04 ± 0.75 h, respectively. MIC for investigated bacterial strains ranged from 1 to 4 mg/L. Postantibiotic effect lasted from 2.10-2.18 ± 0.2 h for Gram-positive to 0.58-0.90 ± 0.05 h for Gram-negative bacteria. PK/PD indices (t > MIC) ranged from 27.08 ± 5.93% to 43.23 ± 6.54% of 8-h dosing interval (SF) and 22.57 ± 8.93% to 49.65 ± 1.95% of 12-h dosing interval (MRF). Plasma levels were below MIC for more than 50% of the dosing interval even for the most sensitive pathogens (MIC = 1 mg/L). During both dosing intervals the total "antibacterial activity" was not longer than 6 h for Gram-positive and 5 h for Gram-negative bacteria for SF and 9 h for Gram-positive and 5 h for Gram-negative bacteria for MRF.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Infecções Bacterianas/tratamento farmacológico
Cefaclor/administração & dosagem
Bactérias Gram-Negativas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Farmacorresistência Bacteriana/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Testes de Sensibilidade Microbiana/métodos
Meia-Idade
Infecções Respiratórias/tratamento farmacológico
Infecções Urinárias/tratamento farmacológico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 69K7K19H4L (Cefaclor)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE


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[PMID]:26525797
[Au] Autor:Berti AD; Theisen E; Sauer JD; Nonejuie P; Olson J; Pogliano J; Sakoulas G; Nizet V; Proctor RA; Rose WE
[Ad] Endereço:Pharmacy Practice Division, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
[Ti] Título:Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for ß-Lactam-Daptomycin Synergy.
[So] Source:Antimicrob Agents Chemother;60(1):451-8, 2015 Nov 02.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced in the presence of ß-lactam antibiotics. This effect is more pronounced with ß-lactam antibiotics that exhibit avid binding to penicillin binding protein 1 (PBP1). Here, we present evidence that PBP1 has a significant role in responding to DAP-induced stress on the cell. Expression of the pbpA transcript, encoding PBP1, was specifically induced by DAP exposure whereas expression of pbpB, pbpC, and pbpD, encoding PBP2, PBP3, and PBP4, respectively, remained unchanged. Using a MRSA COL strain with pbpA under an inducible promoter, increased pbpA transcription was accompanied by reduced susceptibility to, and killing by, DAP in vitro. Exposure to ß-lactams that preferentially inactivate PBP1 was not associated with increased DAP binding, suggesting that synergy in the setting of anti-PBP1 pharmacotherapy results from increased DAP potency on a per-molecule basis. Combination exposure in an in vitro pharmacokinetic/pharmacodynamic model system with ß-lactams that preferentially inactivate PBP1 (DAP-meropenem [MEM] or DAP-imipenem [IPM]) resulted in more-rapid killing than did combination exposure with DAP-nafcillin (NAF) (nonselective), DAP-ceftriaxone (CRO) or DAP-cefotaxime (CTX) (PBP2 selective), DAP-cefaclor (CEC) (PBP3 selective), or DAP-cefoxitin (FOX) (PBP4 selective). Compared to ß-lactams with poor PBP1 binding specificity, exposure of S. aureus to DAP plus PBP1-selective ß-lactams resulted in an increased frequency of septation and cell wall abnormalities. These data suggest that PBP1 activity may contribute to survival during DAP-induced metabolic stress. Therefore, targeted inactivation of PBP1 may enhance the antimicrobial efficiency of DAP, supporting the use of DAP-ß-lactam combination therapy for serious MRSA infections, particularly when the ß-lactam undermines the PBP1-mediated compensatory response.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Daptomicina/farmacologia
Imipenem/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Modelos Estatísticos
Proteínas de Ligação às Penicilinas/genética
Tienamicinas/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacocinética
Cefaclor/farmacologia
Cefotaxima/farmacologia
Cefoxitina/farmacologia
Ceftriaxona/farmacologia
Membrana Celular/efeitos dos fármacos
Membrana Celular/metabolismo
Daptomicina/farmacocinética
Sinergismo Farmacológico
Quimioterapia Combinada
Regulação Bacteriana da Expressão Gênica
Imipenem/farmacocinética
Staphylococcus aureus Resistente à Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/metabolismo
Nafcilina/farmacologia
Proteínas de Ligação às Penicilinas/metabolismo
Regiões Promotoras Genéticas
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Tienamicinas/farmacocinética
Transcrição Genética/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Penicillin-Binding Proteins); 0 (Protein Isoforms); 0 (Thienamycins); 4CNZ27M7RV (Nafcillin); 69K7K19H4L (Cefaclor); 6OEV9DX57Y (Cefoxitin); 71OTZ9ZE0A (Imipenem); 75J73V1629 (Ceftriaxone); FV9J3JU8B1 (meropenem); N2GI8B1GK7 (Cefotaxime); NWQ5N31VKK (Daptomycin)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151104
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.02071-15


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[PMID]:26144658
[Au] Autor:Piccinelli G; Biscaro V; Gargiulo F; Caruso A; De Francesco MA
[Ad] Endereço:Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
[Ti] Título:Characterization and antibiotic susceptibility of Streptococcus agalactiae isolates causing urinary tract infections.
[So] Source:Infect Genet Evol;34:1-6, 2015 Aug.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Streptococcus agalactiae (GBS) has been implicated in urinary tract infections but the microbiological characteristics and antimicrobial susceptibility of these strains are poorly investigated. In this study, 87 isolates recovered from urine samples of patients who had attended the Spedali Civili of Brescia (Italy) and had single organism GBS cultured were submitted to antimicrobial susceptibility testing, molecular characterization of macrolide and levofloxacin resistance, PCR-based capsular typing and analysis of surface protein genes. By automated broth microdilution method, all isolates were susceptible to penicillin, cefuroxime, cefaclor, and ceftriaxone; 80%, 19.5% and 3.4% of isolates were non-susceptible to tetracycline, erythromycin, and levofloxacin, respectively. Macrolide resistance determinants were iMLS(B) (n=1), cMLS(B) (n=10) and M (n=5), associated with ermTR, ermB and mefA/E. Levofloxacin resistance was linked to mutations in gyrA and parC genes. Predominant capsular types were III, Ia, V, Ib and IX. Type III was associated with tetracycline resistance, while type Ib was associated with levofloxacin resistance. Different capsular type-surface protein gene combinations (serotype V-alp2, 3; serotype III-rib; serotype Ia-epsilon) were detected. A variety of capsular types are involved in significant bacteriuria. The emergence of multidrug resistant GBS may become a significant public health concern and highlights the importance of careful surveillance to prevent the emergence of these virulent GBS.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Infecções Estreptocócicas/microbiologia
Streptococcus agalactiae/efeitos dos fármacos
Infecções Urinárias/microbiologia
[Mh] Termos MeSH secundário: Cefaclor/farmacologia
Ceftriaxona/farmacologia
Cefuroxima/farmacologia
DNA Girase/genética
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Farmacorresistência Bacteriana
Eritromicina/farmacologia
Seres Humanos
Levofloxacino/farmacologia
Penicilinas/farmacologia
Infecções Estreptocócicas/tratamento farmacológico
Streptococcus agalactiae/genética
Tetraciclina/farmacologia
Infecções Urinárias/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Penicillins); 63937KV33D (Erythromycin); 69K7K19H4L (Cefaclor); 6GNT3Y5LMF (Levofloxacin); 75J73V1629 (Ceftriaxone); EC 5.99.1.3 (DNA Gyrase); F8VB5M810T (Tetracycline); O1R9FJ93ED (Cefuroxime)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150808
[Lr] Data última revisão:
150808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150707
[St] Status:MEDLINE


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[PMID]:26090434
[Au] Autor:Wang H; Huang H; Cao J; Chui D; Xiao S
[Ad] Endereço:School of Life Science, Beijing Institute of Technology, 5 Zhongguancun Street, South Haidian District, Beijing 100081, China ; Neuroscience Research Institute, Health Science Center, Peking University, Beijing 100191, China.
[Ti] Título:Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities.
[So] Source:Biomed Res Int;2015:697958, 2015.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High performance liquid chromatography tandem mass spectrometry (HPLC MS) has been widely used for ß-lactam antibiotics determination. However, its application to identify impurities of these frequently used drugs is not sufficient at present. In this job, characteristic profiles of the collision induced dissociation (CID) spectra of both ß-lactams and ring-opened ß-lactams were extracted from the MS data of six ß-lactam antibiotics and their forty-five impurities, and were confirmed by the MS data reported in the literature. These characteristics have been successfully applied to rapid differentiation of ß-lactam and ring-opened ß-lactam impurities in cefixime, cefdinir, and cefaclor. However, these characteristic profiles can only be obtained under low activating voltage. They did not display in the high energy activated CID spectra. Diagnostic fragmentations for determining the localization of double bond and substituents on the thiazine ring and the side chain were also observed. In addition, several characteristic fragmentations are hopeful to be used to differentiate the configurations of C-2 on the thiazine ring of ring-opened impurities, which is generally disadvantageous of mass spectrometry. Taken together, forty-five impurities were identified from the capsules of cefixime, cefdinir, and cefaclor.
[Mh] Termos MeSH primário: Antibacterianos/química
Espectrometria de Massas
beta-Lactamas/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Cefaclor/química
Cefixima/química
Cefalosporinas/química
Cromatografia Líquida de Alta Pressão
Seres Humanos
beta-Lactamas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (beta-Lactams); 69K7K19H4L (Cefaclor); 97I1C92E55 (Cefixime); CI0FAO63WC (cefdinir)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150620
[St] Status:MEDLINE
[do] DOI:10.1155/2015/697958


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[PMID]:25601701
[Au] Autor:Qian JQ; Correra TC; Li J; Maître P; Song DQ; Hu CQ
[Ad] Endereço:Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China; National Institutes for Food and Drug Control, Beijing, 100050, China.
[Ti] Título:Differentiation of cefaclor and its delta-3 isomer by electrospray mass spectrometry, infrared multiple photon dissociation spectroscopy and theoretical calculations.
[So] Source:J Mass Spectrom;50(1):265-9, 2015 Jan.
[Is] ISSN:1096-9888
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Cefaclor/análise
Cefaclor/química
Espectrometria de Massas por Ionização por Electrospray/métodos
Espectrofotometria Infravermelho/métodos
[Mh] Termos MeSH secundário: Cefalosporinas/análise
Cefalosporinas/química
Isomerismo
Teoria Quântica
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cephalosporins); 3X11EVM5SU (loracarbef); 69K7K19H4L (Cefaclor)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150120
[Lr] Data última revisão:
150120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150121
[St] Status:MEDLINE
[do] DOI:10.1002/jms.3510


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[PMID]:25542089
[Au] Autor:Majcher A; Lewandrowska A; Herold F; Stefanowicz J; Slowinski T; Mazurek AP; Wieczorek SA; Holyst R
[Ad] Endereço:Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
[Ti] Título:A method for rapid screening of interactions of pharmacologically active compounds with albumin.
[So] Source:Anal Chim Acta;855:51-9, 2015 Jan 15.
[Is] ISSN:1873-4324
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We determine the association constants for ligand-protein complex formation using the flow injection method. We carry out the measurements at high flow rates (F=1 mL min(-1)) of a carrier phase. Therefore, determination of the association constant takes only a few minutes. Injection of 1 nM of the ligand (10 µL of 1 µM concentration of the ligand solution) is sufficient for a single measurement. This method is tested and verified for a number of complexes of selected drugs (cefaclor, etodolac, sulindac) with albumin (BSA). We obtain K=4.45×10(3) M(-1) for cefaclor, K=1.00×10(5) M(-1) for etodolac and K=1.03×10(5) M(-1) for sulindac in agreement with the literature data. We also determine the association constants of 20 newly synthesized 3ß- and 3α-aminotropane derivatives with potential antipsychotic activity--ligands of 5-HT1A, 5-HT2A and D2 receptors with the albumin. Results of the studies reported here indicate that potential antipsychotic drugs bind weakly to the transporter protein (BSA) with K≈10(2)-10(3) M(-1). Our method allows measuring K in a wide range of values (10(2)-10(9) M(-1)). This range depends only on the solubility of the ligand and sensitivity of the detector.
[Mh] Termos MeSH primário: Preparações Farmacêuticas/metabolismo
Soroalbumina Bovina/metabolismo
[Mh] Termos MeSH secundário: Animais
Antipsicóticos/metabolismo
Bovinos
Cefaclor/metabolismo
Etodolac/metabolismo
Ligantes
Ligação Proteica
Sulindaco/metabolismo
Fatores de Tempo
Tropanos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Ligands); 0 (Pharmaceutical Preparations); 0 (Tropanes); 184SNS8VUH (Sulindac); 27432CM55Q (Serum Albumin, Bovine); 2M36281008 (Etodolac); 69K7K19H4L (Cefaclor)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141228
[St] Status:MEDLINE


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[PMID]:25531904
[Au] Autor:Arslan H; Akcay M; Çakir M; Gok A; Yasa B; Dalli M
[Ad] Endereço:Department of Endodontics, Faculty of Dentistry, Atatürk University , Erzurum , Turkey.
[Ti] Título:Comparison of bond strength of self-etch adhesive to pulp chamber dentin after placement of calcium hydroxide and various antibiotic pastes.
[So] Source:Acta Odontol Scand;73(3):226-31, 2015 Apr.
[Is] ISSN:1502-3850
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate the effect of calcium hydroxide, double antibiotic paste (DAP) and triple antibiotic paste (TAP) with minocycline, cefaclor and amoxicillin on the micro tensile bond strength (µTBS) of self-etch adhesive to pulp chamber dentin. MATERIALS AND METHODS: Sixty mandibular first molars were cut horizontally and randomly divided into a control group and five experimental groups, which received an intra-canal dressing, as follows: calcium hydroxide, DAP, TAP with minocycline, TAP with cefaclor and TAP with amoxicillin. After storing the specimens for 4 weeks, the medicaments were removed by irrigation with 10 mL each of the following solution: 2.5% NaOCl, 17% EDTA and distilled water. A self-etch adhesive (Clearfil S3 Bond, Okayama, Japan) was applied and composite resin (Clearfil Majesty Posterior, Kuraray Medical Inc., Japan) was placed into the cavity. A µTBS test was performed on each specimen using a universal test machine. RESULTS: The DAP reduced the µTBS of self-etch adhesive compared to the control group, calcium hydroxide and TAP with minocycline and with cefaclor (p < 0.05). However, the other medicaments did not result in a decreased µTBS of self-etch adhesive to pulp chamber dentin as compared to the control group (p > 0.05). CONCLUSIONS: The use of DAP resulted in a reduced µTBS of self-etch adhesive to pulp chamber dentin.
[Mh] Termos MeSH primário: Antibacterianos/química
Hidróxido de Cálcio/química
Colagem Dentária
Cavidade Pulpar/ultraestrutura
Adesivos Dentinários/química
Dentina/ultraestrutura
Irrigantes do Canal Radicular/química
[Mh] Termos MeSH secundário: Amoxicilina/química
Cefaclor/química
Ciprofloxacino/química
Resinas Compostas/química
Análise do Estresse Dentário
Combinação de Medicamentos
Ácido Edético/química
Seres Humanos
Teste de Materiais
Metronidazol/química
Minociclina/química
Distribuição Aleatória
Cimentos de Resina/química
Hipoclorito de Sódio/química
Estresse Mecânico
Resistência à Tração
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Clearfil S3 Bond); 0 (Composite Resins); 0 (Dentin-Bonding Agents); 0 (Drug Combinations); 0 (Resin Cements); 0 (Root Canal Irrigants); 0 (clearfil majesty); 140QMO216E (Metronidazole); 5E8K9I0O4U (Ciprofloxacin); 69K7K19H4L (Cefaclor); 804826J2HU (Amoxicillin); 9G34HU7RV0 (Edetic Acid); DY38VHM5OD (Sodium Hypochlorite); FYY3R43WGO (Minocycline); PF5DZW74VN (Calcium Hydroxide)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150302
[Lr] Data última revisão:
150302
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:141223
[St] Status:MEDLINE
[do] DOI:10.3109/00016357.2014.992811



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