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Pesquisa : D02.065.589.099.249.200.165 [Categoria DeCS]
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[PMID]:28735237
[Au] Autor:Kim B; Ji K; Kho Y; Kim PG; Park K; Kim K; Kim Y; Kim KT; Choi K
[Ad] Endereço:Department of Environmental Health, Graduate School at Yongin University, Yongin, 17092, Republic of Korea.
[Ti] Título:Effects of chronic exposure to cefadroxil and cefradine on Daphnia magna and Oryzias latipes.
[So] Source:Chemosphere;185:844-851, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cefadroxil and cefradine have frequently been detected in surface waters, however toxicological studies in aquatic organisms have mostly been limited to acute lethal effects. In the present study, endocrine disruption caused by cefadroxil and cefradine, and its underlying mechanism were investigated by chronic exposure of Daphnia magna (21 d) and Oryzias latipes (120 d). In medaka fish, the effects on growth, mortality, and reproduction, as well as on the levels of hormones and genes related to the hypothalamic-pituitary-gonad (HPG) axis, were investigated after 120 d exposure. In D. magna, the chronic effects on growth were observed at the highest concentration of 83.0 mg L cefadroxil and 80.8 mg L cefradine. The growth of juvenile fish was significantly impaired by exposure to cefradine. Following exposure to cefadroxil and cefradine for 120 d, sex-dependent changes in E2 hormones were observed and their levels were supported by the regulation of genes along the HPG axis. We found that chronic exposure to cefadroxil and cefradine impaired growth and reproduction in a freshwater invertebrate and fish, and altered the levels of sex hormones and genes associated with the HPG axis in fish.
[Mh] Termos MeSH primário: Cefadroxila/toxicidade
Cefradina/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Daphnia/efeitos dos fármacos
Disruptores Endócrinos/toxicidade
Sistema Endócrino/efeitos dos fármacos
Água Doce
Hormônios Esteroides Gonadais
Masculino
Oryzias/fisiologia
Reprodução/efeitos dos fármacos
Testes de Toxicidade Crônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Gonadal Steroid Hormones); 0 (Water Pollutants, Chemical); 280111G160 (Cefadroxil); F1BC02I72W (Cephradine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


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[PMID]:28192085
[Au] Autor:Chen X; Keep RF; Liang Y; Zhu HJ; Hammarlund-Udenaes M; Hu Y; Smith DE
[Ad] Endereço:Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA. Electronic address: xmchen@umich.edu.
[Ti] Título:Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study.
[So] Source:Biochem Pharmacol;131:89-97, 2017 May 01.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Peptide transporter 2 (PEPT2) is a high-affinity low-capacity transporter belonging to the proton-coupled oligopeptide transporter family. Although many aspects of PEPT2 structure-function are known, including its localization in choroid plexus and neurons, its regional activity in brain, especially extracellular fluid (ECF), is uncertain. In this study, the pharmacokinetics and regional brain distribution of cefadroxil, a ß-lactam antibiotic and PEPT2 substrate, were investigated in wildtype and Pept2 null mice using in vivo intracerebral microdialysis. Cefadroxil was infused intravenously over 4h at 0.15mg/min/kg, and samples obtained from plasma, brain ECF, cerebrospinal fluid (CSF) and brain tissue. A permeability-surface area experiment was also performed in which 0.15mg/min/kg cefadroxil was infused intravenously for 10min, and samples obtained from plasma and brain tissues. Our results showed that PEPT2 ablation significantly increased the brain ECF and CSF levels of cefadroxil (2- to 2.5-fold). In contrast, there were no significant differences between wildtype and Pept2 null mice in the amount of cefadroxil in brain cells. The unbound volume of distribution of cefadroxil in brain was 60% lower in Pept2 null mice indicating an uptake function for PEPT2 in brain cells. Finally, PEPT2 did not affect the influx clearance of cefadroxil, thereby, ruling out differences between the two genotypes in drug entry across the blood-brain barriers. These findings demonstrate, for the first time, the impact of PEPT2 on brain ECF as well as the known role of PEPT2 in removing peptide-like drugs, such as cefadroxil, from the CSF to blood.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Encéfalo/metabolismo
Cefadroxila/farmacocinética
Simportadores/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Cefadroxila/sangue
Camundongos
Camundongos Knockout
Microdiálise
Simportadores/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Symporters); 0 (hydrogen-coupled oligopeptide transporter PepT2); 280111G160 (Cefadroxil)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE


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[PMID]:27494757
[Au] Autor:de Marco BA; Salgado HR
[Ad] Endereço:a Department of Drugs and Medicines , School of Pharmaceutical Sciences, São Paulo State University , Araraquara , SP , Brazil.
[Ti] Título:Characteristics, Properties and Analytical Methods of Cefadroxil: A Review.
[So] Source:Crit Rev Anal Chem;47(2):93-98, 2017 Mar 04.
[Is] ISSN:1547-6510
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infections are the second leading cause of mortality worldwide and there are many reasons justifying the need for further studies of antimicrobial agents. Cefadroxil is a drug that has bactericidal activity and broad spectrum of action. Quantitative analyzes about cefadroxil are essential for the understanding of bioavailability, bioequivalence, and therapeutic control, which will ensure the product's characteristics and patients' safety. Thus, this study highlights a brief literature review about the drug and the existing methods developed for the determination of cefadroxil found in official and scientific papers. According to the methods found in literature, liquid chromatography and spectrophotometry of absorption in the ultraviolet region prevailed over the others. Importantly, most of the solvents used for the development of the described analytical methods are toxic to the environment, making it necessary to educate researchers and pharmaceutical companies to use nontoxic solvents to provide environmental-friendly methods and better benefits to equipments and mainly to analysts.
[Mh] Termos MeSH primário: Cefadroxila/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Estrutura Molecular
Espectrofotometria Ultravioleta
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
280111G160 (Cefadroxil)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170201
[Lr] Data última revisão:
170201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE
[do] DOI:10.1080/10408347.2016.1219649


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[PMID]:27208060
[Au] Autor:Corson AH; Myers BE; Dinges WL
[Ad] Endereço:Department of Hospital Medicine.
[Ti] Título:Why isn't cefadroxil used more often?
[So] Source:Am J Health Syst Pharm;73(11):754-5, 2016 Jun 01.
[Is] ISSN:1535-2900
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Cefadroxila/administração & dosagem
Uso de Medicamentos
[Mh] Termos MeSH secundário: Antibacterianos/efeitos adversos
Antibacterianos/farmacocinética
Cefadroxila/efeitos adversos
Cefadroxila/farmacocinética
Uso de Medicamentos/tendências
Gastroenteropatias/induzido quimicamente
Seres Humanos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 280111G160 (Cefadroxil)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170120
[Lr] Data última revisão:
170120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE
[do] DOI:10.2146/ajhp150841


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[PMID]:27087092
[Au] Autor:Rahim N; Naqvi SB; Alam M; Rasheed A; Khalique UA
[Ti] Título:Comparative bioavailability and pharmacokinetic study of Cefadroxil capsules in male healthy volunteers of Pakistan.
[So] Source:Pak J Pharm Sci;29(2):453-9, 2016 Mar.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The current study was aimed to judge bioequivalence between two formulations of cefadroxil capsules as guided by FDA guidelines. Another objective was to conduct pharmacokinetic evaluation in Pakistani population. A single-dose, randomized, cross-over pharmacokinetic study was conducted during the month of May'2013 to August'2013. Washout period was one week. Fourteen healthy male adult volunteers were enrolled in the study, however twelve completed the study. Cefadroxil plasma concentration was analyzed by using validated HPLC method. Protein precipitation was achieved by the addition of 6% tri chloro acetic acid in 1:1 ratio and detection was done at 260 nm. Retention time was 7.792 min and correlation coefficient (R2) was 0.9953 showing linearity of the method. Blood sampling was carried out at different time intervals after administration of either test (TEST 500 mg) or reference (REF® 500 mg) formulation. Pharmacokinetic parameters (AUC0→ ∞, AUC0→ t, Cmax, Tmax, t1/2 and kel) were calculated using Kinetica® PK/PD software. The geometric mean ratios and 90% confidence interval (CI) of these pharmacokinetic parameters for cefadroxil (test and reference) formulations were 0.986 (90.83-106.98%) for AUC0→ t; 0.967 (89.13-104.92%) for AUC0→ ∞ and 0.999 (91.06-109.69%) for Cmax. The differences between Tmax of both formulations were not found to be statistically significant (p-value was more than 0.05). The 90% CI of the test/reference AUC and Cmax ratio of cefadroxil were within the FDA recommended range for bioequivalence. Maximum plasma concentration Cmax was 12.5 µg/ml for test and 12.47 µg/ml for reference formulations. Average time to reach Cmax for test and reference formulation was 1.54 and 1.5 hrs. The two formulations of cefadroxil studied during the above study were verified bioequivalent. Maximum plasma concentration of cefadroxil was lower than those mentioned in some previous studies, while Tmax and half-life were near to values reported in literature.
[Mh] Termos MeSH primário: Antibacterianos/farmacocinética
Cefadroxila/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Adulto
Antibacterianos/administração & dosagem
Antibacterianos/sangue
Área Sob a Curva
Disponibilidade Biológica
Cápsulas
Cefadroxila/administração & dosagem
Cefadroxila/sangue
Cromatografia Líquida de Alta Pressão
Estudos Cross-Over
Meia-Vida
Voluntários Saudáveis
Seres Humanos
Modelos Lineares
Masculino
Taxa de Depuração Metabólica
Paquistão
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Capsules); 280111G160 (Cefadroxil)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160418
[Lr] Data última revisão:
160418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE


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[PMID]:26979860
[Au] Autor:Hu Y; Smith DE
[Ad] Endereço:Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA. Electronic address: yongjun@umich.edu.
[Ti] Título:Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice.
[So] Source:Biochem Pharmacol;107:81-90, 2016 May 01.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PepT1 (SLC15A1) is a high-capacity low-affinity transporter that is important in the absorption of digested di/tripeptides from dietary protein in the small intestine. PepT1 is also crucial for the intestinal uptake and absorption of therapeutic agents such as the ß-lactam aminocephalosporins and antiviral prodrugs. Species differences, however, have been observed in PepT1-mediated intestinal absorption and pharmacokinetics, thereby, making it more difficult to predict systemic drug exposure. In the present study, we evaluated the in situ intestinal permeability of the PepT1 substrate cefadroxil in wildtype and humanized PepT1 (huPepT1) mice, and the in vivo absorption and disposition of drug after escalating oral doses. The in situ perfusions indicated that cefadroxil had a twofold higher affinity (i.e., twofold lower Km) for jejunal PepT1 in huPepT1 mice, lower but substantial permeability in all regions of the small intestine, and low but measureable permeability in the colon as compared to wildtype animals. The in vivo experiments indicated almost superimposable pharmacokinetic profiles between the two genotypes after intravenous bolus dosing of cefadroxil. In contrast, after oral dose escalation, the systemic exposure of cefadroxil was reduced in huPepT1 mice as compared to wildtype animals. Moreover, the AUC and Cmax versus dose relationships were nonlinear for huPepT1 but not wildtype mice, and similar to that observed from human subjects. In conclusion, our findings indicate that huPepT1 mice may provide a valuable tool in the drug discovery process by better predicting the oral pharmacokinetic profiles of PepT1 substrates in humans.
[Mh] Termos MeSH primário: Antibacterianos/farmacocinética
Cefadroxila/farmacocinética
Absorção Intestinal
Mucosa Intestinal/metabolismo
Jejuno/metabolismo
Simportadores/metabolismo
[Mh] Termos MeSH secundário: Animais
Antibacterianos/administração & dosagem
Antibacterianos/sangue
Antibacterianos/metabolismo
Cefadroxila/administração & dosagem
Cefadroxila/sangue
Cefadroxila/metabolismo
Colo/metabolismo
Cruzamentos Genéticos
Relação Dose-Resposta a Droga
Meia-Vida
Seres Humanos
Técnicas In Vitro
Camundongos Endogâmicos C57BL
Camundongos Knockout
Camundongos Transgênicos
Transportador 1 de Peptídeos
Perfusão
Especificidade da Espécie
Simportadores/genética
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Peptide Transporter 1); 0 (SLC15A1 protein, human); 0 (Slc15a1 protein, mouse); 0 (Symporters); 280111G160 (Cefadroxil)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE


  7 / 398 MEDLINE  
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[PMID]:26372256
[Au] Autor:Xie Y; Shen H; Hu Y; Feng MR; Smith DE
[Ad] Endereço:a Department of Pharmaceutical Sciences , College of Pharmacy, University of Michigan , Ann Arbor , MI , USA.
[Ti] Título:Population pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice.
[So] Source:Xenobiotica;46(4):342-9, 2016.
[Is] ISSN:1366-5928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. Cefadroxil is a broad-spectrum ß-lactam antibiotic that is widely used in the treatment of various infectious diseases. Currently, poor understanding of the drug's pharmacokinetic profiles and disposition mechanism(s) prevents determining optimal dosage regimens and achieving ideal antibacterial responses in patients. In the present retrospective study, we developed a population pharmacokinetic model of cefadroxil in wild-type and Pept2 knockout mice using the nonlinear mixed effect modeling (NONMEM) approach. 2. Cefadroxil pharmacokinetics were best described by a two-compartment model, with both saturable and nonsaturable elimination processes to/from the central compartment. Through this modeling approach, pharmacokinetic parameters in wild-type and Pept2 knockout mice were well estimated, respectively, as follows: volume of central compartment V1 (3.43 versus 4.23 mL), volume of peripheral compartment V2 (5.98 versus 8.61 mL), intercompartment clearance Q (0.599 versus 0.586 mL/min) and linear elimination rate constant K10 (0.111 versus 0.070 min(-1)). Moreover, the secretion kinetics (i.e. V(m1) = 17.6 nmoL/min and K(m1) = 37.1 µM) and reabsorption kinetics (i.e. V(m2) = 15.0 nmoL/min and K(m2) = 27.1 µM) of cefadroxil were quantified in kidney, for the first time, under in vivo conditions. 3. Our model provides a unique tool to quantitatively predict the dose-dependent nonlinear disposition of cefadroxil, as well as the potential for transporter-mediated drug interactions.
[Mh] Termos MeSH primário: Cefadroxila/farmacocinética
Rim/metabolismo
Modelos Biológicos
Simportadores/deficiência
[Mh] Termos MeSH secundário: Administração Intravenosa
Animais
Transporte Biológico/efeitos dos fármacos
Cefadroxila/administração & dosagem
Rim/efeitos dos fármacos
Camundongos Knockout
Reprodutibilidade dos Testes
Simportadores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Symporters); 0 (hydrogen-coupled oligopeptide transporter PepT2); 280111G160 (Cefadroxil)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150916
[St] Status:MEDLINE
[do] DOI:10.3109/00498254.2015.1080881


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Texto completo SciELO Chile
[PMID]:26633114
[Au] Autor:Piñera C; Loyola F; Hernández P
[Ti] Título:[Nephronia in pediatrics: part of the spectrum of upper urinary tract infections. Clinical cases and review of the literature].
[Ti] Título:Nefronia en pediatría: dentro del espectro de las infecciones urinarias. Serie clínica y revisión de la literatura..
[So] Source:Rev Chilena Infectol;32(5):564-8, 2015 Oct.
[Is] ISSN:0717-6341
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:Nephronia or focal acute nephritis corresponds to a localized inflammatory non-liquefactive kidney infection which may involve parenchyma of one or more renal lobes. It has been suggested that nephronia is part of the spectrum of upper urinary tract infections between acute pyelonephritis and renal abscess. It is associated with a prolonged clinical course, higher levels of inflammatory markers and an increased risk of renal scarring, compared to pyelonephritis. Ultrasound plays a useful role. Nephronia is an under-diagnosed condition, thus, clinical suspicion is important for early diagnosis and appropriate treatment. We present three paediatric cases, and a review of the literature.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Cefadroxila/uso terapêutico
Nefrite/diagnóstico por imagem
[Mh] Termos MeSH secundário: Doença Aguda
Criança
Pré-Escolar
Feminino
Seres Humanos
Nefrite/tratamento farmacológico
Cintilografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 280111G160 (Cefadroxil)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE


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[PMID]:26142506
[Au] Autor:Rahim N; Naqvi SB; Shakeel S; Iffat W; Muhammad IN
[Ad] Endereço:Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
[Ti] Título:Determination of Cefadroxil in Tablet/Capsule formulations by a validated Reverse Phase High Performance Liquid Chromatographic method.
[So] Source:Pak J Pharm Sci;28(4):1345-9, 2015 Jul.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:An innovative, selective and rapid reversed phase High Performance Liquid Chromatographic (RP-HPLC) method for the analysis of cefadroxil in bulk material and oral solid dosage forms has been developed and validated. The chromatographic system consisted of Sil-20A auto sampler, LC-20A pump and SPD-20A UV/visible detector. The separation was achieved by C18 column at ambient temperature with a mobile phase consisting of methanol: Phosphate buffer (10: 90) at a flow rate of 1.5 ml/min. The method is reproducible, repeatable (%RSD for intra-day and inter-day ranged between 1.75-5.33% and 0.58-2.69%) and linear (R2=0.9935). The LOD and LOQ of the method were 0.5 and 1.0 µg/ml, respectively. The present RP-HPLC method was found to be sensitive, accurate, precise, rapid and cost effective that can be efficiently used in QC/QA laboratories for routine analysis of the raw materials as well as oral dosage formulations of cefadroxil.
[Mh] Termos MeSH primário: Cefadroxila/análise
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia de Fase Reversa/métodos
[Mh] Termos MeSH secundário: Cápsulas
Química Farmacêutica
Limite de Detecção
Comprimidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsules); 0 (Tablets); 280111G160 (Cefadroxil)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150706
[Lr] Data última revisão:
150706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150706
[St] Status:MEDLINE


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[PMID]:25614968
[Au] Autor:Chen H; Son S; Zhang F; Yan J; Li Y; Ding H; Ding L
[Ad] Endereço:College of Chemistry, Jilin University, Changchun 130012, China.
[Ti] Título:Rapid preparation of molecularly imprinted polymers by microwave-assisted emulsion polymerization for the extraction of florfenicol in milk.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;983-984:32-8, 2015 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, we proposed a rapid and simple method for the preparation of molecularly imprinted polymers (MIPs) by emulsion polymerization. The polymerization process was accelerated by microwave heating, and the reaction time was greatly shortened. The obtained MIPs were spherical in shape and exhibited a uniform morphology. The MIPs with selectivity and high affinity to florfenicol were successfully applied as solid-phase extraction materials to extract and clean up the florfenicol in milk, followed by liquid chromatography-tandem mass spectrometry (LC-MS) analysis. The parameters affecting the performance of extraction and LC-MS analysis were evaluated. The detection limit of the method was 4.1ngmL(-1). The relative standard deviations of intra- and inter-day were in the range of 3.5-4.7% and 3.9-7.5%, respectively.
[Mh] Termos MeSH primário: Emulsões/química
Micro-Ondas
Leite/química
Impressão Molecular/métodos
Polimerização
Polímeros/química
Tianfenicol/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Cefadroxila/química
Cloranfenicol/química
Cromatografia Líquida
Concentração de Íons de Hidrogênio
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Roxitromicina/química
Espectroscopia de Infravermelho com Transformada de Fourier
Espectrometria de Massas em Tandem
Temperatura Ambiente
Tianfenicol/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Emulsions); 0 (Polymers); 21KOF230FA (Roxithromycin); 280111G160 (Cefadroxil); 66974FR9Q1 (Chloramphenicol); 9J97307Y1H (florfenicol); FLQ7571NPM (Thiamphenicol)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150209
[Lr] Data última revisão:
150209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150124
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde