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Pesquisa : D02.065.589.099.249.200.165.125 [Categoria DeCS]
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[PMID]:26776155
[Au] Autor:Yao Z; Li J; Liu Z; Zheng L; Fan N; Zhang Y; Jia N; Lv J; Liu N; Zhu X; Du J; Lv C; Xie F; Liu Y; Wang X; Fei Z; Gao C
[Ad] Endereço:Department of Neurosurgery, No. 150 Central Hospital of PLA, Luoyang, Henan 471031, China.
[Ti] Título:Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.
[So] Source:Mol Biosyst;12(3):729-36, 2016 Mar.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eukaryotic elongation factor-2 kinase (eEF2K), a unique calcium/calmodulin-dependent protein kinase, is well known to regulate apoptosis, autophagy and ER stress in many types of human cancers. Therefore, eEF2K would be regarded as a promising therapeutic target; however, the eEF2K-regulated mechanism and its targeted inhibitor still remain to be discovered in cancer. Herein, we constructed a protein-protein interaction (PPI) network of eEF2K and achieved an eEF2K-regulated ER stress subnetwork by bioinformatics prediction. Then, we found that the differential protein expressions involved in ER stress in the context of si-eEF2K-treated MCF-7 and MDA-MB-436 cells by iTRAQ-based analyses, respectively. Integrated into these aforementioned results, we constructed a core eEF2K-regulated ER stress subnetwork in breast cancer cells. Subsequently, we screened a series of candidate compounds targeting eEF2K and discovered a novel eEF2K inhibitor (cefatrizine) with an anti-proliferative activity toward breast cancer cells. Moreover, we found that cefatrizine induced ER stress in both MCF-7 and MDA-MB-436 cells. Interestingly, we demonstrated that the mechanism of cefatrizine-induced ER stress was in good agreement with our bioinformatics and proteomics-based results. In conclusion, these results demonstrate that a novel eEF2K inhibitor (cefatrizine) induces ER stress in breast cancer cells by integrating bioinformatics prediction, proteomics analyses and experimental validation, which would provide a clue for exploring more mechanisms of eEF2K and its targeted inhibitors in cancer therapy.
[Mh] Termos MeSH primário: Neoplasias da Mama/enzimologia
Neoplasias da Mama/patologia
Cefatrizina/farmacologia
Biologia Computacional/métodos
Quinase do Fator 2 de Elongação/antagonistas & inibidores
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Proteômica/métodos
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Quinase do Fator 2 de Elongação/metabolismo
Feminino
Seres Humanos
Inibidores de Proteínas Quinases/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 8P4W949T8K (Cefatrizine); EC 2.7.1.17 (EEF2K protein, human); EC 2.7.11.20 (Elongation Factor 2 Kinase)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE
[do] DOI:10.1039/c5mb00848d


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[PMID]:23894823
[Au] Autor:Pan J; Wang L; Li D; Ye L
[Ad] Endereço:China National Pharmaceutical Group Sichuan Industrial Institute of Antibiotics, Chengdu 610052, Sichuan, China.
[Ti] Título:[Synthesis of cefatrizine by recombinant alpha-amino acid ester hydrolase].
[So] Source:Sheng Wu Gong Cheng Xue Bao;29(4):501-9, 2013 Apr.
[Is] ISSN:1000-3061
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the enzymatic route of cefatrizine synthesis, alpha-amino acid ester hydrolase (AEH) gene was cloned from the whole genome of Xanthomonas rubrillineans, and expressed heterologously in Escherichia coli BL21 (DE3). The effects of temperature, pH and substrates' molar ratio upon the transformation yield of cefatrizine by purified recombinant AEH were investigated. The monomer of AEH was determined as 70 kDa by SDS-PAGE. The optimal pH and temperature reaction were (6.0 +/- 0.1) and 36 degrees C for cefatrizine synthesis. The transformation yield was 64.3% under 36 degrees C, pH (6.0 +/- 0.1), when the concentrations of two substrates were about 30 mmol/L (7-ATTC) and 120 mmol/L (HPGM x HCl), respectively, and the enzyme consumption was 22 U/mL. The results pave the way for optimization of the industrial enzymatic synthesis of cefatrizine.
[Mh] Termos MeSH primário: Hidrolases de Éster Carboxílico/biossíntese
Cefatrizina/metabolismo
Xanthomonas/enzimologia
[Mh] Termos MeSH secundário: Hidrolases de Éster Carboxílico/genética
Catálise
Clonagem Molecular
Escherichia coli/genética
Escherichia coli/metabolismo
Cinética
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/genética
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Recombinant Proteins); 8P4W949T8K (Cefatrizine); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.43 (alpha-amino acid esterase)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:130730
[Lr] Data última revisão:
130730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130731
[St] Status:MEDLINE


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[PMID]:17604254
[Au] Autor:Sultana N; Arayne MS
[Ad] Endereço:Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
[Ti] Título:In vitro activity of cefadroxil, cephalexin, cefatrizine and cefpirome in presence of essential and trace elements.
[So] Source:Pak J Pharm Sci;20(4):305-10, 2007 Oct.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Evidences supporting the introduction of metallic elements in several biological processes are rapidly accumulating. Likewise, many drugs possess modified toxicological and pharmacological properties when in the form of metal complexes. In order to ascertain the role of various essential and trace element complexation on the antibacterial activity of various cephalosporins, the synergistic or antagonistic behavior of cefadroxil, cephalexin, cefatrizine and cefpirome in presence of essential and trace elements has been studied and compared with the parent drug. The essential and trace elements comprised of magnesium, calcium, chromium, manganese, ferric, cobalt, nickel, copper, zinc and cadmium in the form of their chloride. These studies were carried out by observing the minimum inhibitory concentration (MIC) using agar dilution method and compared with the MIC'S of the standard cephalosporins against various species of Gram (+) and Gram (-) microorganisms such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus faecalis, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi and Shigella dysenteriae. Different dilutions of cephalosporins and salts of essential and trace elements were used in these studies. The ratio of the drug and metal salts was 1:1 and the reactions were carried out at two different temperatures as 37 degrees C and 60 degrees C in order to study the complex formation. The aim of our study was on one hand to evaluate the changes in microbiological activity of the standard cephalosporins after in vitro metal interactions to study the synergetic or antagonistic behavior of the later through the difference in MICs values of these cephalosporins and on the other hand to access the bioassay directed extent of drug metal complexations. Our investigation reveal that interaction of above cephalosporins with essential and trace elements cause antagonistic effect in many cases which was shown by decrease in antimicrobial activity of cephalosporins and MIC values were increased.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Cefalosporinas/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Metais/química
Oligoelementos/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Cefadroxila/química
Cefadroxila/farmacologia
Cefatrizina/química
Cefatrizina/farmacologia
Cefalexina/química
Cefalexina/farmacologia
Cefalosporinas/química
Contagem de Colônia Microbiana
Testes de Sensibilidade Microbiana
Sais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (Metals); 0 (Salts); 0 (Trace Elements); 280111G160 (Cefadroxil); 8P4W949T8K (Cefatrizine); OBN7UDS42Y (Cephalexin); S72Q2F09HY (cefpirome)
[Em] Mês de entrada:0708
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070703
[St] Status:MEDLINE


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[PMID]:17135753
[Au] Autor:Papantoniou N; Ismailos G; Daskalakis G; Karabinas C; Mesogitis S; Papapanagiotou A; Antsaklis A
[Ad] Endereço:First Department of Obstetrics and Gynecology, University of Athens, Alexandra Hospital, Athens, Greece.
[Ti] Título:Pharmacokinetics of oral cefatrizine in pregnant and non-pregnant women with reference to fetal distribution.
[So] Source:Fetal Diagn Ther;22(2):100-6, 2007.
[Is] ISSN:1015-3837
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effect of gestation on the pharmacokinetics of orally administered beta-lactams, choosing cefatrizine as the model antibiotic. SETTING: A tertiary teaching hospital. DESIGN: Prospective study. METHODS: In 20 women with affected fetuses, 17 by beta-thalassemia major and 3 with congenital malformations, termination of gestation between 19 and 24 weeks was induced by intra-amniotic administration of prostaglandin F(2)(alpha). Pharmacokinetics of cefatrizine in maternal and fetal blood were studied after the administration of three 1 g doses of oral cefatrizine, every 12 h. Twenty female non-pregnant volunteers consisted the control group. RESULTS: Gestation was found to decrease substantially both cefatrizine oral bioavailability and maximum serum plasma concentration (42.8 and 44.5%, respectively) but increased elimination half-life. This effect can be attributed to a substantial increase of the apparent volume of distribution of cefatrizine in relation to a moderate increase of clearance that occurs during pregnancy. Fetal serum cefatrizine levels were lower for the first few hours after administration and then exceeded the corresponding maternal ones. CONCLUSIONS: Our results indicate that gestation decreases the oral bioavailability of cefatrizine. A delay in the maternal drug elimination compared to non-pregnant controls was more pronounced in the fetus.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Antibacterianos/farmacocinética
Cefatrizina/administração & dosagem
Cefatrizina/farmacocinética
Feto/metabolismo
Troca Materno-Fetal
Gravidez/metabolismo
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Adulto
Antibacterianos/sangue
Área Sob a Curva
Disponibilidade Biológica
Cefatrizina/sangue
Feminino
Sangue Fetal/metabolismo
Idade Gestacional
Grécia
Meia-Vida
Hospitais de Ensino
Seres Humanos
Taxa de Depuração Metabólica
Estudos Prospectivos
Valores de Referência
Fatores de Tempo
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 8P4W949T8K (Cefatrizine)
[Em] Mês de entrada:0703
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061201
[St] Status:MEDLINE


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[PMID]:15030898
[Au] Autor:Choi HG; Jun HW; Kim DD; Sah H; Yoo BK; Yong CS
[Ad] Endereço:College of Pharmacy, Yeungnam University, Gyongsan 712-749, South Korea.
[Ti] Título:Simultaneous determination of cefatrizine and clavulanic acid in dog plasma by HPLC.
[So] Source:J Pharm Biomed Anal;35(1):221-31, 2004 Apr 01.
[Is] ISSN:0731-7085
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A rapid and specific high-performance liquid chromatographic method was developed and validated for the simultaneous determination of cefatrizine and clavulanic acid in the plasma of beagle dog. The sample pretreatment procedure involved reaction of clavulanic acid with 1,2,4-triazole, which readily produced a derivative with its maximum UV absorption at 314 nm. This derivative was separated in a reverse-phase C-18 column without being interfered by other components present in plasma. Cefatrizine, however, was not derivatized and, therefore determined directly at 269 nm. Sulfanilamide was used as an internal standard. The retention times of sulfanilamide, the derivative, and cefatrizine were, 3.5, 4.9, and 6.0 min, respectively. The assay showed linearity from 2 to 100 microg/ml for cefatrizine and from 1 to 50 microg/ml for clavulanic acid. Precision expressed as R.S.D. ranged from 4.2 to 18.2% for cefatrizine and 5.5 to 15.8% for clavulanic acid. Accuracy ranged from 97.9 to 120% (lower limit of quantitation) for cefatrizine and from 97.7 to 119.2% for clavulanic acid. Extraction efficiencies for cefatrizine, clavulanic acid, and internal standard from dog plasma averaged 79.8+/-5.8%, 84.8+/-6.2%, and 89.0+/-3.8%, respectively. This method was employed successfully to follow the time course of the concentration of cefatrizine and clavulanic acid in beagle dogs following oral administration of cefatrizine and clavulanic acid.
[Mh] Termos MeSH primário: Cefatrizina/sangue
Ácido Clavulânico/sangue
[Mh] Termos MeSH secundário: Administração Oral
Animais
Calibragem
Cromatografia Líquida de Alta Pressão
Cães
Estabilidade de Medicamentos
Masculino
Padrões de Referência
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
23521W1S24 (Clavulanic Acid); 8P4W949T8K (Cefatrizine)
[Em] Mês de entrada:0410
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040320
[St] Status:MEDLINE


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[PMID]:14653131
[Au] Autor:Zhang X; Zhao BC
[Ad] Endereço:Department of Burn, Second Xiangya Hospital, Central South University, Changsha 410011, China.
[Ti] Título:[Infective pathogens and drug resistance in burned patients].
[So] Source:Hunan Yi Ke Da Xue Xue Bao;28(4):405-8, 2003 Aug.
[Is] ISSN:1000-5625
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To find out the changes in the infective pathogens and their drug resistance in burned patients. METHODS: The patients were divided into two groups. The first group was from July 1991 to June 1996, and the second group was from July 1996 to June 2001. The bacteria of burned body surface and blood were cultured, and the bacteria and their drug sensitivity were analyzed. RESULTS: Gram-negative bacteria were the major bacteria in burn infection, among which Pseudomonas aeruginosa ranked the top. Staphylococcus aureous ranked the first among the Gram-positive bacteria, and the isolation rate of methicillin resistant Staphylococcus aureus increased; The isolation rate of Enterobacter cloacae (10.4%), Escherichia coli (8.3%), Klebsiella pneumoniae (7.3%), and fungus (4.2%) all rose. The antibiotic resistant strains of Pseudomonas aeruginosa and Staphylococcus aureous increased. CONCLUSION: The changes in pathogens of burn infection and bacterial drug resistance are related to the wide use of broad spectrum antibiotics such as cefazidime and imepenem, suggesting that dynamic observation of changes in pathogenic strains and sensitivity of bacteria to antibiotics are useful for clinical prevention and cure of burn infection.
[Mh] Termos MeSH primário: Queimaduras/microbiologia
Resistência a Meticilina
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Cefatrizina/farmacologia
Criança
Pré-Escolar
Farmacorresistência Bacteriana
Enterobacter cloacae/efeitos dos fármacos
Infecções por Enterobacteriaceae
Feminino
Seres Humanos
Lactente
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Infecções por Pseudomonas
Infecções Estafilocócicas
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
8P4W949T8K (Cefatrizine)
[Em] Mês de entrada:0404
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031205
[St] Status:MEDLINE


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[PMID]:9704917
[Au] Autor:Yu LX; Amidon GL
[Ad] Endereço:College of Pharmacy, The University of Michigan, Ann Arbor, USA.
[Ti] Título:Saturable small intestinal drug absorption in humans: modeling and interpretation of cefatrizine data.
[So] Source:Eur J Pharm Biopharm;45(2):199-203, 1998 Mar.
[Is] ISSN:0939-6411
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This report describes an extended compartmental absorption and transit (CAT) model to estimate saturable small intestinal absorption. This model simultaneously considers passive absorption, saturable absorption, degradation, and transit kinetics in the human small intestine. Using cefatrizine as a model drug, we demonstrated that the extended CAT model, along with intravenous pharmacokinetic parameters, was able to explain the observed oral plasma concentration-time profiles. The model predicted comparable passive and saturable absorption characteristics for cefatrizine, particularly at high dose. The predicted fraction of dose absorbed was 74% at 250 mg, 61% at 500 mg, and 48% at 1000 mg, in agreement with the reported experimental data. The simulation study showed that no single physiological factor (gastric emptying, small intestinal transit, and absorption mechanism) could account for the large variability of cefatrizine absorption observed in the literature.
[Mh] Termos MeSH primário: Cefatrizina/farmacocinética
Cefalosporinas/farmacocinética
Intestino Delgado/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Absorção Intestinal
Modelos Biológicos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cephalosporins); 8P4W949T8K (Cefatrizine)
[Em] Mês de entrada:9812
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980815
[St] Status:MEDLINE


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[PMID]:9657046
[Au] Autor:Matsuda K; Yuasa H; Watanabe J
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
[Ti] Título:Dose dependency in the gastrointestinal absorption of cefatrizine: correlation between in vivo and in situ.
[So] Source:Biol Pharm Bull;21(6):604-9, 1998 Jun.
[Is] ISSN:0918-6158
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We evaluated the dose-dependent (saturable) gastrointestinal absorption of cefatrizine, an aminocephalosporin transported by peptide carriers, in rats by a physiological mechanism-based approach to clarify its absorption characteristics and to examine the in vitro (in situ)-in vivo correlation in intestinal transport. With an increase in oral dose (mumol/5 ml/kg) from 5 (low) to 50 (high), the intestinal absorption rate constant (ka), which was estimated by analysis of gastrointestinal disposition, decreased markedly, from 0.301 to 0.056 min-1. This decrease was ascribable to the saturability of intestinal membrane transport, of which the concentration dependency in the perfused intestine was similar in extent to the dose dependency in ka. However, the apparent absorption rate constant (ka'), which was estimated by analysis of plasma concentrations after oral administration, decreased only modestly from 0.037 to 0.023 min-1. This was associated with the result that, at the low dose, ka' was far smaller than ka and comparable with k(g) (gastric emptying rate constant), suggesting gastric emptying-limited absorption. At the high dose, where intestinal cefatrizine absorption was less efficient, ka' was closer to ka than k(g). It was also observed that the bioavailability was close to unity, independent of dose, suggesting that the intestinal transit time is long enough to achieve complete absorption, even at the high dose, where intestinal cefatrizine absorption is less efficient. Thus, it was found that the effect of saturability in the intestinal transport of cefatrizine is apparently attenuated in its overall gastrointestinal absorption because of the involvement of gastric emptying and intestinal transit time as additional physiological factors to define absorption. It was also found that a scaling factor is required to correlate the intestinal membrane transport between in vitro (in situ) and in vivo, though this remains to be verified to be utilized for developing oral drug delivery strategies and optimizing oral drug therapy.
[Mh] Termos MeSH primário: Cefatrizina/metabolismo
Cefalosporinas/metabolismo
Absorção Intestinal
[Mh] Termos MeSH secundário: Administração Oral
Animais
Transporte Biológico
Cefatrizina/administração & dosagem
Cefatrizina/sangue
Cefatrizina/farmacocinética
Cefalosporinas/administração & dosagem
Cefalosporinas/sangue
Cefalosporinas/farmacocinética
Relação Dose-Resposta a Droga
Intestinos/anatomia & histologia
Intestinos/metabolismo
Masculino
Ratos
Ratos Wistar
Estômago/anatomia & histologia
Estômago/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cephalosporins); 8P4W949T8K (Cefatrizine)
[Em] Mês de entrada:9809
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980710
[St] Status:MEDLINE


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[PMID]:9578165
[Au] Autor:Verhaegen J; Verbist L
[Ad] Endereço:Department of Microbiology, University Hospitals, KU Leuven, Belgium.
[Ti] Título:In-vitro activity of 21 beta-lactam antibiotics against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae.
[So] Source:J Antimicrob Chemother;41(3):381-5, 1998 Mar.
[Is] ISSN:0305-7453
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:MICs of 21 beta-lactams were determined by agar dilution against 283 penicillin-susceptible (pen-S), 122 intermediate (pen-I) and 23 fully penicillin-resistant (pen-R) pneumococci. MICs of all beta-lactams increased with increasing MICs of penicillin. Clometocillin was the most active penicillin against pen-I or pen-R pneumococci. All oral cephalosporins except cefuroxime and cefpodoxime were less active than penicillin and none was satisfactory against pen-I or pen-R pneumococci. The parenteral third- and fourth-generation cephalosporins (except ceftazidime) were similar in activity to penicillin against pen-S isolates. Cefpirome showed the lowest mean MICs against pen-I and pen-R strains.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Resistência às Penicilinas
Penicilinas/farmacologia
Streptococcus pneumoniae/efeitos dos fármacos
beta-Lactamas/farmacologia
[Mh] Termos MeSH secundário: Amoxicilina/farmacologia
Ampicilina/farmacologia
Antibacterianos/administração & dosagem
Carbapenêmicos/farmacologia
Cefaclor/farmacologia
Cefadroxila/farmacologia
Cefatrizina/farmacologia
Cefixima
Cefotaxima/análogos & derivados
Cefotaxima/farmacologia
Ceftazidima/farmacologia
Ceftizoxima/análogos & derivados
Ceftizoxima/farmacologia
Ceftriaxona/farmacologia
Cefuroxima/farmacologia
Cefalosporinas/farmacologia
Cefradina/farmacologia
Resistência Microbiana a Medicamentos
Resistência a Múltiplos Medicamentos
Seres Humanos
Testes de Sensibilidade Microbiana
Piperacilina/farmacologia
Infecções Pneumocócicas/microbiologia
Sorotipagem
Especificidade da Espécie
Streptococcus pneumoniae/classificação
beta-Lactamas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carbapenems); 0 (Cephalosporins); 0 (Penicillins); 0 (beta-Lactams); 280111G160 (Cefadroxil); 4R5TV783X3 (cefetamet); 69K7K19H4L (Cefaclor); 75J73V1629 (Ceftriaxone); 7C782967RD (Ampicillin); 7R4F94TVGY (cefpodoxime); 804826J2HU (Amoxicillin); 807PW4VQE3 (cefepime); 8P4W949T8K (Cefatrizine); 97I1C92E55 (Cefixime); 9M416Z9QNR (Ceftazidime); C43C467DPE (Ceftizoxime); F1BC02I72W (Cephradine); IW71N46B4Y (ceftibuten); N2GI8B1GK7 (Cefotaxime); O1R9FJ93ED (Cefuroxime); S72Q2F09HY (cefpirome); X00B0D5O0E (Piperacillin)
[Em] Mês de entrada:9806
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980513
[St] Status:MEDLINE


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[PMID]:9812556
[Au] Autor:Sheng R; Wang A; Liu X
[Ad] Endereço:Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing.
[Ti] Título:[Lyme neuroborreliosis with acute meningitis as the presenting manifestation: report of a case].
[So] Source:Zhonghua Nei Ke Za Zhi;36(1):21-4, 1997.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To enhance the understanding of Lyme disease, a case of Lyme neuroborreliosis with acute meningitis as the presenting manifestation was reported. The diagnosis was confirmed by elevated serum antibody response to B. burgdorferi using both ELISA and Western blotting, excluding other causes of neurological abnormalities and the typical response of our patient to antibiotics. This case indicates the existence of Lyme disease in Beijing area. If the etiology of a meningitis with lymphocytic pleocytosis is not known, it is important that Lyme neuroborreliosis should be considered as one of the differential diagnoses and detection of antibody to B. burgdorferi in serum and cerebrospinal fluid performed in time. A brief review of the literature including epidemiology, clinical menifestations, diagnosis and treatment of Lyme disease was made.
[Mh] Termos MeSH primário: Doença de Lyme/diagnóstico
Meningites Bacterianas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Anticorpos Antibacterianos/sangue
Grupo Borrelia Burgdorferi/imunologia
Grupo Borrelia Burgdorferi/isolamento & purificação
Cefatrizina/uso terapêutico
Cefalosporinas/uso terapêutico
Diagnóstico Diferencial
Feminino
Seres Humanos
Doença de Lyme/tratamento farmacológico
Doença de Lyme/microbiologia
Meningites Bacterianas/tratamento farmacológico
Meningites Bacterianas/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Cephalosporins); 8P4W949T8K (Cefatrizine)
[Em] Mês de entrada:9901
[Cu] Atualização por classe:140226
[Lr] Data última revisão:
140226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970101
[St] Status:MEDLINE



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