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Fotocópia
[PMID]:17638010
[Au] Autor:Sabolic I; Asif AR; Budach WE; Wanke C; Bahn A; Burckhardt G
[Ad] Endereço:Molecular Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia. sabolic@imi.hr
[Ti] Título:Gender differences in kidney function.
[So] Source:Pflugers Arch;455(3):397-429, 2007 Dec.
[Is] ISSN:0031-6768
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sex hormones influence the development of female (F) and male (M) specific traits and primarily affect the structure and function of gender-specific organs. Recent studies also indicated their important roles in regulating structure and/or function of nearly every tissue and organ in the mammalian body, including the kidneys, causing gender differences in a variety of characteristics. Clinical observations in humans and studies in experimental animals in vivo and in models in vitro have shown that renal structure and functions under various physiological, pharmacological, and toxicological conditions are different in M and F, and that these differences may be related to the sex-hormone-regulated expression and action of transporters in the apical and basolateral membrane of nephron epithelial cells. In this review we have collected published data on gender differences in renal functions, transporters and other related parameters, and present our own microarray data on messenger RNA expression for various transporters in the kidney cortex of M and F rats. With these data we would like to emphasize the importance of sex hormones in regulation of a variety of renal transport functions and to initiate further studies of gender-related differences in kidney structure and functions, which would enable us to better understand occurrence and development of various renal diseases, pharmacotherapy, and drug-induced nephrotoxicity in humans and animals.
[Mh] Termos MeSH primário: Hormônios Esteroides Gonadais/fisiologia
Rim/fisiologia
[Mh] Termos MeSH secundário: Animais
Ciclacilina/toxicidade
Feminino
Seres Humanos
Rim/efeitos dos fármacos
Masculino
Modelos Biológicos
Transportadores de Ânions Orgânicos/fisiologia
Proteínas de Transporte de Cátions Orgânicos/fisiologia
RNA Mensageiro/metabolismo
Receptores Androgênicos/fisiologia
Receptores Estrogênicos/fisiologia
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Organic Anion Transporters); 0 (Organic Cation Transport Proteins); 0 (RNA, Messenger); 0 (Receptors, Androgen); 0 (Receptors, Estrogen); 72ZJ154X86 (Cyclacillin)
[Em] Mês de entrada:0806
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070720
[St] Status:MEDLINE


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[PMID]:15340850
[Au] Autor:Irie M; Terada T; Okuda M; Inui K
[Ad] Endereço:Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, 606-8507 Kyoto, Japan. inui@kuhp.kyoto-u.ac.jp
[Ti] Título:Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2.
[So] Source:Pflugers Arch;449(2):186-94, 2004 Nov.
[Is] ISSN:0031-6768
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Small peptides and some pharmacologically active compounds are absorbed from the small intestine by the apical H(+)-coupled peptide transporter 1 (PEPT1) and the basolateral peptide transporter. Here we investigated the efflux properties of the basolateral peptide transporter in Caco-2 cells using two strategies, efflux measurements and a kinetic analysis of transepithelial transport of glycylsarcosine (Gly-Sar). [(14)C]Gly-Sar efflux through the basolateral membrane was not affected significantly by the external pH. Both approaches revealed that the basolateral peptide transporter was saturable in the efflux direction, and that the affinity was lower than that in the influx direction. For two peptide-like drugs, there was no difference in substrate recognition by the basolateral peptide transporter between the two sides of the membrane. Using the kinetic parameters of PEPT1 and the basolateral peptide transporter, a computational model of Gly-Sar transport in Caco-2 cells was constructed. The simulation fitted the experimental data well. Our findings suggested that substrate affinity of the basolateral peptide transporter is apparently asymmetric, but pH-dependence and substrate specificity are symmetric for the two directions of transport. The behaviour of Gly-Sar in Caco-2 cells could be predicted by a mathematical model describing the peptide transporters.
[Mh] Termos MeSH primário: Polaridade Celular/fisiologia
Mucosa Intestinal/citologia
Mucosa Intestinal/metabolismo
Proteínas de Membrana Transportadoras/metabolismo
Modelos Biológicos
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Transporte Biológico/efeitos dos fármacos
Transporte Biológico/fisiologia
Células CACO-2
Radioisótopos de Carbono
Cefalosporinas/farmacologia
Simulação por Computador
Ciclacilina/farmacologia
Dipeptídeos/farmacocinética
Seres Humanos
Concentração de Íons de Hidrogênio
Cinética
Modelos Lineares
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carbon Radioisotopes); 0 (Cephalosporins); 0 (Dipeptides); 0 (Membrane Transport Proteins); 29816-01-1 (glycylsarcosine); 72ZJ154X86 (Cyclacillin); 97599-47-8 (peptide permease); IW71N46B4Y (ceftibuten)
[Em] Mês de entrada:0507
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040902
[St] Status:MEDLINE


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Fotocópia
[PMID]:9374833
[Au] Autor:Terada T; Saito H; Mukai M; Inui K
[Ad] Endereço:Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan.
[Ti] Título:Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.
[So] Source:Am J Physiol;273(5 Pt 2):F706-11, 1997 Nov.
[Is] ISSN:0002-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PEPT1 and PEPT2 are H(+)-coupled peptide transporters expressed preferentially in the intestine and kidney, respectively, which mediate uphill transport of oligopeptides and peptide-like drugs such as beta-lactam antibiotics. In the present study, we have compared the recognition of beta-lactam antibiotics by LLC-PK1 cells stably transfected with PEPT1 or PEPT2 cDNA. Cyclacillin (aminopenicillin) and ceftibuten (anionic cephalosporin without an alpha-amino group) showed potent inhibitory effects on the glycylsarcosine uptake in the PEPT1-expressing cells. Other beta-lactams, such as cephalexin, cefadroxil, and cephradine (aminocephalosporins), inhibited modestly the PEPT1-mediated glycylsarcosine uptake. Except for ceftibuten, these beta-lactams showed much more potent inhibitions on the glycylsarcosine uptake via PEPT2 than via PEPT1. Comparison of the inhibition constant (Ki) values between cefadroxil and cephalexin suggested that the hydroxyl group at the NH2-terminal phenyl ring increased affinity for both PEPT1 and PEPT2. It is concluded that PEPT2 has a much higher affinity for beta-lactam antibiotics having an alpha-amino group than PEPT1 and that substituents at the NH2-terminal side chain of these drugs are involved in the recognition by both peptide transporters.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Proteínas de Transporte/metabolismo
Dipeptídeos/farmacocinética
Simportadores
[Mh] Termos MeSH secundário: Animais
Antibacterianos/metabolismo
Transporte Biológico
Proteínas de Transporte/biossíntese
Cefalosporinas/farmacologia
Ciclacilina/farmacologia
Concentração de Íons de Hidrogênio
Rim
Cinética
Células LLC-PK1
Transportador 1 de Peptídeos
Ratos
Proteínas Recombinantes/metabolismo
Relação Estrutura-Atividade
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carrier Proteins); 0 (Cephalosporins); 0 (Dipeptides); 0 (Peptide Transporter 1); 0 (Recombinant Proteins); 0 (Slc15a1 protein, rat); 0 (Symporters); 0 (hydrogen-coupled oligopeptide transporter PepT2); 29816-01-1 (glycylsarcosine); 72ZJ154X86 (Cyclacillin); IW71N46B4Y (ceftibuten)
[Em] Mês de entrada:9712
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:971231
[St] Status:MEDLINE


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Fotocópia
[PMID]:8583383
[Au] Autor:Mizen L; Berry V; Woodnutt G
[Ad] Endereço:Microbial Infectivity Department, SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.
[Ti] Título:The influence of uptake from the gastrointestinal tract and first-pass effect on oral bioavailability of (Z)-alkyloxyimino penicillins.
[So] Source:J Pharm Pharmacol;47(9):725-30, 1995 Sep.
[Is] ISSN:0022-3573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have investigated the contribution of uptake from the gastrointestinal tract and first-pass effect to the poor oral bioavailability of a series of (Z)-alkyloxyimino penicillins in mice. Investigative studies in gut sacs and perfused small intestine demonstrated that these penicillins were able to pass across the mucosal epithelium although to a lesser extent than amoxycillin and cyclacillin, both of which exhibit excellent oral bioavailability in man and animals. In the jejunal gut sacs the mucosal to serosal flux for BRL 44154 was approximately half that of amoxycillin and four times less than that of cyclacillin, and for all, uptake was pH dependent. The serosal to mucosal fluxes were however similar for these compounds and significantly lower than mucosal to serosal fluxes, suggesting involvement of carrier mechanisms in uptake from the mucosal surface. The order of results for the alkyloxyimino penicillins paralleled that observed for oral bioavailability in the mouse. For the alkyloxyimino penicillins, between 5.5 and 9.9% was taken up from the perfused intestine, values which were significantly less than those for amoxycillin (13.2%) and cyclacillin (33.3%). However, uptake was concentration-dependent for BRL 44154 as it was for amoxycillin, thus confirming the possible use of carrier mechanisms in absorption. These observations suggest that the poor peripheral blood concentrations of the alkyloxyimino penicillins achieved after oral dosing were not a consequence of the inability of the compounds to cross the mucosal epithelium. The biliary clearance of the alkyloxyimino penicillins was, however, considerably greater than for amoxycillin and cyclacillin, a finding which may well have been a contributory factor to the comparatively low peripheral concentrations of BRL 44154 and its analogues achieved after oral administration.
[Mh] Termos MeSH primário: Amoxicilina/farmacocinética
Ciclacilina/farmacocinética
Intestino Delgado/metabolismo
Penicilinas/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Amoxicilina/administração & dosagem
Animais
Disponibilidade Biológica
Ciclacilina/administração & dosagem
Relação Dose-Resposta a Droga
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/metabolismo
Jejuno/efeitos dos fármacos
Jejuno/metabolismo
Masculino
Camundongos
Penicilinas/administração & dosagem
Perfusão
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Penicillins); 72ZJ154X86 (Cyclacillin); 804826J2HU (Amoxicillin)
[Em] Mês de entrada:9603
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950901
[St] Status:MEDLINE


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Fotocópia
[PMID]:7592745
[Au] Autor:Ganapathy ME; Brandsch M; Prasad PD; Ganapathy V; Leibach FH
[Ad] Endereço:Department of Medicine, Medical College of Georgia, Augusta 30912, USA.
[Ti] Título:Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2.
[So] Source:J Biol Chem;270(43):25672-7, 1995 Oct 27.
[Is] ISSN:0021-9258
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was initiated to determine if there are differences in the recognition of beta -lactam antibiotics as substrates between intestinal and renal peptide transporters, PEPT 1 and PEPT 2. Reverse transcription-coupled polymerase chain reaction and/or Northern blot analysis have established that the human intestinal cell line Caco-2 expresses PEPT 1 but not PEPT 2, whereas the rat proximal tubule cell line SKPT expresses PEPT 2 but not PEPT 1. Detailed kinetic analysis has provided unequivocal evidence for participation of PEPT 2 in SKPT cells in the transport of the dipeptide glycylsarcosine and the aminocephalosporin cephalexin. The substrate recognition pattern of PEPT 1 and PEPT 2 was studied with cefadroxil (a cephalosporin) and cyclacillin (a penicillin) as model substrates for the peptide transporters constitutively expressed in Caco-2 cells (PEPT 1) and SKPT cells (PEPT 2). Cyclacillin was 9-fold more potent than cefadroxil in competing with glycylsacosine for uptake via PEPT 1. In contrast, cefadroxil was 13-fold more potent than cyclacillin in competing with the dipeptide for uptake via PEPT 2. The substrate recognition pattern of PEPT 1 and PEPT 2 was also investigated using cloned human peptide transporters functionally expressed in HeLa cells. Expression of PEPT 1 or PEPT 2 in HeLa cells was found to induce H(+)-coupled cephalexin uptake in these cells. As was the case with Caco-2 cells and SKPT cells, the uptake of glycylsarcosine induced in HeLa cells by PEPT 1 cDNA and PEPT 2 cDNA was inhibitable by cyclacillin and cefadroxil. Again, the PEPT 1 cDNA-induced dipeptide uptake was inhibited more potently by cyclacillin than by cefadroxil, and the PEPT 2 cDNA-induced dipeptide uptake was inhibited more potently by cefadroxil than by cyclacillin. It is concluded that there are marked differences between the intestinal and renal peptide transporters in the recognition of beta -lactam antibiotics as substrates.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Proteínas de Transporte/metabolismo
Intestino Delgado/metabolismo
Rim/metabolismo
Simportadores
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Transporte Biológico/efeitos dos fármacos
Northern Blotting
Proteínas de Transporte/genética
Cefadroxila/metabolismo
Células Cultivadas
Cefalexina/metabolismo
Cefalosporinas/metabolismo
Ciclacilina/metabolismo
Dipeptídeos/metabolismo
Relação Dose-Resposta a Droga
Seres Humanos
Intestino Delgado/citologia
Rim/citologia
Penicilinas/metabolismo
Transportador 1 de Peptídeos
Reação em Cadeia da Polimerase
RNA Mensageiro/análise
Ratos
Proteínas Recombinantes/metabolismo
Vírus Vaccinia/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carrier Proteins); 0 (Cephalosporins); 0 (Dipeptides); 0 (Penicillins); 0 (Peptide Transporter 1); 0 (RNA, Messenger); 0 (Recombinant Proteins); 0 (SLC15A1 protein, human); 0 (Slc15a1 protein, rat); 0 (Symporters); 0 (hydrogen-coupled oligopeptide transporter PepT2); 280111G160 (Cefadroxil); 29816-01-1 (glycylsarcosine); 72ZJ154X86 (Cyclacillin); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:9512
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:951027
[St] Status:MEDLINE


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[PMID]:11537280
[Au] Autor:Oh D-M; Sinko PJ; Amidon GL
[Ad] Endereço:College of Pharmacy, The University of Michigan, Ann Arbor 48109-1065.
[Ti] Título:Characterization of the oral absorption of several aminopenicillins: determination of intrinsic membrane absorption parameters in the rat intestine in situ.
[So] Source:Int J Pharm;85(1-3):181-7, 1992 Sep 20.
[Is] ISSN:0378-5173
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The absorption mechanism of several penicillins was characterized using in situ single-pass intestinal perfusion in the rat. The intrinsic membrane parameters were determined using a modified boundary layer model (fitted value +/- S.E.): Jmax* = 11.78 +/- 1.88 mM, Km = 15.80 +/- 2.92 mM, Pm* = 0, Pc* = 0.75 +/- 0.04 for ampicillin; Jmax* = 0.044 +/- 0.018 mM, Km = 0.058 +/- 0.026 mM, Pm* = 0.558 +/- 0.051, Pc* = 0.757 +/- 0.088 for amoxicillin; and Jmax* = 16.30 +/- 3.40 mM, Km = 14.00 +/- 3.30 mM, Pm* = 0, Pc* = 1.14 +/- 0.05 for cyclacillin. All of the aminopenicillins studied demonstrated saturable absorption kinetics as indicated by their concentration-dependent wall permeabilities. Inhibition studies were performed to confirm the existence of a nonpassive absorption mechanism. The intrinsic wall permeability (Pw*) of 0.01 mM ampicillin was significantly lowered by 1 mM amoxicillin and the Pw* of 0.01 mM amoxicillin was reduced by 2 mM cephradine consistent with competitive inhibition.
[Mh] Termos MeSH primário: Amoxicilina/farmacocinética
Ampicilina/farmacocinética
Ciclacilina/farmacocinética
Absorção Intestinal/efeitos dos fármacos
Jejuno/metabolismo
[Mh] Termos MeSH secundário: Absorção/efeitos dos fármacos
Animais
Transporte Biológico/efeitos dos fármacos
Masculino
Perfusão
Permeabilidade
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
72ZJ154X86 (Cyclacillin); 7C782967RD (Ampicillin); 804826J2HU (Amoxicillin)
[Em] Mês de entrada:9506
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:S
[Da] Data de entrada para processamento:920920
[St] Status:MEDLINE


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[PMID]:1820862
[Au] Autor:Margarit F; Moreno-Dalmau J; Obach R; Peraire C; Plá-Delfina JM
[Ad] Endereço:Department of Pharmacy, University of Barcelona, Spain.
[Ti] Título:Intestinal absorption kinetics of a series of aminopenicillins and azidocillin. A comparative study in the rat.
[So] Source:Eur J Drug Metab Pharmacokinet;Spec No 3:102-7, 1991.
[Is] ISSN:0378-7966
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Intestinal absorption rate constants of amoxicillin, ampicillin, epicillin, cyclacillin and azidocillin, by means of a static in situ intestinal perfusion method has been estimated. Luminal remaining antibiotic concentrations were determined using a standard microbiological technique. In order to establish statistically better absorption kinetics, five dose levels were used, ranging from 10 to 1000 micrograms/ml, and first order, Michaelis-Menten and combined first-order and Michaelis-Menten differential model equations were fitted to experimental data found for each antibiotic. According to the AIC test, the best equation for absorption kinetics was selected. Amoxicillin and ampicillin absorption mechanisms were better described by combined kinetics, while for cyclacillin and epicillin the most probable kinetics was that of Michaelis-Menten. For azidocillin, the only non-aminopenicillin component of this series, first order kinetics should be statistically selected.
[Mh] Termos MeSH primário: Absorção Intestinal
Penicilina G/análogos & derivados
Penicilinas/farmacocinética
[Mh] Termos MeSH secundário: Amoxicilina/farmacocinética
Ampicilina/análogos & derivados
Ampicilina/farmacocinética
Animais
Ciclacilina/farmacocinética
Masculino
Modelos Biológicos
Penicilina G/farmacocinética
Ratos
Ratos Endogâmicos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Penicillins); 3LU1L73C8Y (epicillin); 72ZJ154X86 (Cyclacillin); 7C782967RD (Ampicillin); 804826J2HU (Amoxicillin); Q42T66VG0C (Penicillin G); R8XDP7L3SL (azidocillin)
[Em] Mês de entrada:9208
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910101
[St] Status:MEDLINE


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[PMID]:3708715
[Au] Autor:Bone M; Symonds J; Dougan P
[Ti] Título:Penetration of ciclacillin into bronchial secretions.
[So] Source:Chemioterapia;5(2):105-8, 1986 Apr.
[Is] ISSN:0392-906X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The penetration of ciclacillin into bronchial secretions was investigated in 105 patients undergoing bronchoscopy after a single oral dose of 500 mg ciclacillin. Comparison was made with 26 patients who received 500 mg ampicillin by mouth. Over a 6 to 8 hour period, ciclacillin achieved significantly higher levels in bronchial secretions but no statistically significant difference between serum ampicillin and ciclacillin levels was detected.
[Mh] Termos MeSH primário: Brônquios/secreção
Ciclacilina/metabolismo
Penicilinas/metabolismo
Escarro/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Ampicilina/administração & dosagem
Ampicilina/sangue
Ampicilina/metabolismo
Broncoscopia
Ciclacilina/administração & dosagem
Ciclacilina/sangue
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Penicillins); 72ZJ154X86 (Cyclacillin); 7C782967RD (Ampicillin)
[Em] Mês de entrada:8606
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:860401
[St] Status:MEDLINE


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PubMed Central Texto completo
[PMID]:3535660
[Au] Autor:Scheld WM; Sydnor A; Farr B; Gratz JC; Gwaltney JM
[Ti] Título:Comparison of cyclacillin and amoxicillin for therapy for acute maxillary sinusitis.
[So] Source:Antimicrob Agents Chemother;30(3):350-3, 1986 Sep.
[Is] ISSN:0066-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cyclacillin, a new aminosalicylic semisynthetic penicillin, was compared with amoxicillin for the therapy of acute bacterial maxillary sinusitis in 80 patients (ages, 12 to 70 years) in a prospective, double-blind, randomized clinical trial. Direct sinus aspirations for quantitative culture were done for all patients before and after 10 days of therapy. Both drugs were administered at a dosage of 500 mg orally three times daily. Among culture-positive patients, clinical cure was achieved in 23 of 26 patients and 25 of 27 patients treated with cyclacillin and amoxicillin, respectively, for an overall cure rate of 91%. Bacteriologic failure occurred in 9% (4 of 44 patients); 3 of the 4 failures were in the cyclacillin group. There was no correlation between clinical or bacteriologic cure and the results of sinus transillumination (clear, dark) at follow-up. Initial direct sinus aspirates were positive in 57 of 80 cases (70%): 25 (44%) of these were the result of Streptococcus pneumoniae and 23 (40%) were the result of Haemophilus influenzae. All of these isolates were susceptible (MIC, less than or equal to 0.5 microgram/ml) to both study drugs; no ampicillin-resistant H. influenzae was recovered. On day 10 of therapy, mean concentrations of both drugs in serum were 2.5 to 2.7 micrograms/ml, but no antibiotic was detectable in 20 of 21 simultaneous sinus aspirates. Adverse effects (rash, diarrhea) were infrequent and similar in both groups. Cyclacillin appears equivalent to amoxicillin in the therapy of acute maxillary sinusitis.
[Mh] Termos MeSH primário: Amoxicilina/uso terapêutico
Ciclacilina/uso terapêutico
Penicilinas/uso terapêutico
Sinusite/tratamento farmacológico
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Adulto
Idoso
Criança
Ensaios Clínicos como Assunto
Método Duplo-Cego
Seres Humanos
Seio Maxilar
Testes de Sensibilidade Microbiana
Meia-Idade
Distribuição Aleatória
Sinusite/microbiologia
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Penicillins); 72ZJ154X86 (Cyclacillin); 804826J2HU (Amoxicillin)
[Em] Mês de entrada:8612
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:860901
[St] Status:MEDLINE


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Fotocópia
[PMID]:4083501
[Au] Autor:Haginaka J; Wakai J
[Ti] Título:High-performance liquid chromatographic assay of ampicillin, amoxicillin and ciclacillin in serum and urine using a pre-column reaction with 1,2,4-triazole and mercury(II) chloride.
[So] Source:Analyst;110(11):1277-81, 1985 Nov.
[Is] ISSN:0003-2654
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Amoxicilina/análise
Ampicilina/análise
Ciclacilina/análise
Penicilinas/análise
[Mh] Termos MeSH secundário: Amoxicilina/sangue
Amoxicilina/urina
Ampicilina/sangue
Ampicilina/urina
Fenômenos Químicos
Química
Cromatografia Líquida de Alta Pressão
Ciclacilina/sangue
Ciclacilina/urina
Seres Humanos
Cloreto de Mercúrio
Triazóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Penicillins); 0 (Triazoles); 53GH7MZT1R (Mercuric Chloride); 72ZJ154X86 (Cyclacillin); 7C782967RD (Ampicillin); 804826J2HU (Amoxicillin)
[Em] Mês de entrada:8602
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:851101
[St] Status:MEDLINE



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