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[PMID]:29458554
[Au] Autor:Osaka S; Okuzumi K; Koide S; Tamai K; Sato T; Tanimoto K; Tomita H; Suzuki M; Nagano Y; Shibayama K; Arakawa Y; Nagano N
[Ad] Endereço:1​Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Nagano, Japan.
[Ti] Título:Genetic shifts in methicillin-resistant Staphylococcus aureus epidemic clones and toxin gene profiles in Japan: comparative analysis among pre-epidemic, epidemic and post-epidemic phases.
[So] Source:J Med Microbiol;67(3):392-399, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The decline in methicillin-resistant Staphylococcus aureus (MRSA) isolation rates has become a general observation worldwide, including Japan. We hypothesized that some genetic shift in MRSA might cause this phenomenon, and therefore we investigated the genetic profiles among MRSA clinical isolates obtained from three different epidemic phases in Japan. METHODOLOGY: A total of 353 MRSA isolates were selected from 202 medical facilities in 1990 (pre-epidemic phase), 2004 (epidemic phase) and 2016 (post-epidemic phase). Molecular typing was performed by PCR detection of 22 genes using the polymerase chain reaction (PCR)-based ORF typing (POT) system, including an additional eight genes including small genomic islets and seven toxin genes. RESULTS: Isolates with a POT1 of score 93, identified as presumed clonal complex (pCC)5-staphylococcal cassette chromosome mec (SCCmec) type II including ST5-SCCmec type II New York/Japan clone, represented the major epidemic MRSA lineage in 1990 and 2004. In 2016, however, a marked decrease in isolates with a POT1 score of 93, along with changes in the epidemiology of toxin genes carried, was noted, where the carriers of tst genes including the tst-sec combination were markedly reduced, and those possessing the seb gene alone were markedly increased. Rather, isolates with a POT1 score of 106, including pCC1 or pCC8 among the isolates with SCCmec type IV, which often links to community-associated MRSA, were predominant. Interestingly, the pCC1 and pCC8 lineages were related to sea and tst-sec carriage, respectively. CONCLUSIONS: Over time, a transition in MRSA genetic profiles from a POT1 score of 93 in 1990 and 2004 to 106 in 2014 was found in Japan.
[Mh] Termos MeSH primário: Toxinas Bacterianas/genética
Epidemias
Deriva Genética
Staphylococcus aureus Resistente à Meticilina/genética
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/microbiologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Infecção Hospitalar/epidemiologia
Exotoxinas/genética
Seres Humanos
Japão/epidemiologia
Leucocidinas/genética
Meticilina/farmacologia
Resistência a Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Testes de Sensibilidade Microbiana
Tipagem Molecular
Fatores de Virulência/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Toxins); 0 (Exotoxins); 0 (Leukocidins); 0 (Virulence Factors); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000687


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[PMID]:29328999
[Au] Autor:Wei H; Mao F; Ni S; Chen F; Li B; Qiu X; Hu L; Wang M; Zheng X; Zhu J; Lan L; Li J
[Ad] Endereço:Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.
[Ti] Título:Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections.
[So] Source:Eur J Med Chem;145:235-251, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Inhibition of S. aureus diapophytoene desaturase (CrtN) could serve as an alternative approach for addressing the tricky antibiotic resistance by blocking the biosynthesis of carotenoid pigment which shields the bacterium from host oxidant killing. In this study, we designed and synthesized 44 derivatives with piperonyl scaffold targeting CrtN and the structure-activity relationships (SARs) were examined extensively to bring out the discovery of 21b with potent efficacy and better hERG safety profile compared to the first class CrtN inhibitor benzocycloalkane derivative 2. Except the excellent pigment inhibitory activity against wild-type S. aureus, 21b also showed excellent pigment inhibition against four pigmented MRSA strains. In addition, H O killing and human whole blood killing assays proved 21b could sensitize S. aureus to be killed under oxidative stress conditions. Notably, the murine study in vivo validated the efficacy of 21b against pigmented S. aureus Newman, vancomycin-intermediate S. aureus Mu50 and linezolid-resistant S. aureus NRS271.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Proteínas de Bactérias/antagonistas & inibidores
Farmacorresistência Bacteriana/efeitos dos fármacos
Oxirredutases/antagonistas & inibidores
Butóxido de Piperonila/farmacologia
Infecções Estafilocócicas/tratamento farmacológico
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/síntese química
Antibacterianos/química
Proteínas de Bactérias/metabolismo
Relação Dose-Resposta a Droga
Descoberta de Drogas
Seres Humanos
Linezolida/farmacologia
Meticilina/farmacologia
Camundongos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Oxirredutases/metabolismo
Butóxido de Piperonila/análogos & derivados
Butóxido de Piperonila/química
Staphylococcus aureus/enzimologia
Relação Estrutura-Atividade
Vancomicina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 6Q205EH1VU (Vancomycin); EC 1.- (CrtN protein, Staphylococcus aureus); EC 1.- (Oxidoreductases); ISQ9I6J12J (Linezolid); LWK91TU9AH (Piperonyl Butoxide); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE


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[PMID]:28468636
[Au] Autor:Guérin F; Fines-Guyon M; Meignen P; Delente G; Fondrinier C; Bourdon N; Cattoir V; Léon A
[Ad] Endereço:Université de Caen Normandie, EA 4655 (équipe "Antibio-résistance"), F-14032, Caen, France.
[Ti] Título:Nationwide molecular epidemiology of methicillin-resistant Staphylococcus aureus responsible for horse infections in France.
[So] Source:BMC Microbiol;17(1):104, 2017 05 03.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolated in horse infections is not well documented, especially in France. The aim of the study was to evaluate the prevalence of MRSA isolates in horse infections from 2007 to 2013 in France and to characterize phenotypically and genotypically this collection. RESULTS: Out of 1393 S. aureus horse isolates, 85 (6.1%) were confirmed to be MRSA. Interestingly, the prevalence of MRSA significantly increased from 2007-2009 to 2010-2013 (0.7 vs. 9.5%, P <0.0001). Resistance to methicillin was due to the presence of the mecA gene in 84 strains (98.8%) while one strain (1.2%) possessed the mecC gene. The vast majority of the strains (83/85, 97.6%) was resistant to at least three different classes of antibiotics. Multi-locus sequence typing (MLST) showed that MRSA strains belonged mainly since not all belong to two sequence types (STs): ST398 (53/85, 62.4%) and ST8 (28/85, 32.9%). It is worth to note that all ST398 MRSA isolates were detected in the period 2010-2013. Other molecular typing methods were also used, such SCC analysis, spa typing and rep-PCR (Diversilab, bioMérieux). All these four techniques were in good agreement, with spa typing and rep-PCR being more discriminative than MLST and SCC typing. CONCLUSIONS: This study is the first epidemiological study in France with extensive characterization of MRSA isolates associated with horse infections in stud farms. It shows that there is a significant increase of MRSA prevalence between 2007 and 2013, which mainly results from the spread of ST398 clones. It also highlights the importance of horses as a potential reservoir of important antimicrobial resistance genes.
[Mh] Termos MeSH primário: Doenças dos Cavalos/epidemiologia
Doenças dos Cavalos/microbiologia
Staphylococcus aureus Resistente à Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Epidemiologia Molecular
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/veterinária
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
França/epidemiologia
Genes Bacterianos/genética
Genótipo
Cavalos
Meticilina/farmacologia
Resistência a Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Testes de Sensibilidade Microbiana
Tipagem de Sequências Multilocus/métodos
Tipagem de Sequências Multilocus/veterinária
Fenótipo
Reação em Cadeia da Polimerase/métodos
Reação em Cadeia da Polimerase/veterinária
Prevalência
Infecções Estafilocócicas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-016-0924-z


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[PMID]:28964280
[Au] Autor:Fellner A; Marom T; Muallem-Kalmovich L; Shlamkovitch N; Eviatar E; Lazarovitch T; Pitaro J
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300 Zerifin, Israel.
[Ti] Título:Pediatric neck abscesses: No increase in methicillin-resistant Staphylococcus aureus.
[So] Source:Int J Pediatr Otorhinolaryngol;101:112-116, 2017 Oct.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Recent studies from Western countries showed an increased incidence rate of methicillin-resistant Staphylococcus aureus (MRSA) isolated from pediatric neck abscesses cultures. We sought to examine the microbiology and antibiotic susceptibility of such samples over a 10-year period, and particularly of Staphylococcus aureus (SA), in order to determine whether a similar trend exists in our institution. METHODS: A retrospective chart review of children ≤18 years that underwent needle aspiration or surgical drainage of neck abscesses, including suppurative lymphadenitis, retropharyngeal abscesses, and parapharyngeal abscesses was conducted between 1/1/06-31/12/15. RESULTS: Sixty-two children were identified with a male predominance (34, 55%). The median age was 2 years. There were 37 (60%) suppurative lymphadenitis, 15 (24%) parapharyngeal abscess, and 10 (16%) retropharyngeal abscess cases. Twenty-nine (47%) children received antibiotic treatment prior to admission, most commonly ß-lactam agents. Of them, 15 (52%) had positive cultures, including 7 (47%) with SA. On admission, 45 (73%) children had already received amoxicillin-clavulanate. Of those who did not improve, 16 (26%) received ceftriaxone and clindamycin. Twenty-one (38%) cultures were negative. The most common isolated bacteria were SA in 13 (24%), Streptococcus pyogenes in 7 (13%), and Streptococcus viridians group in 9 (16%). Of the SA isolates, there was only 1 (8%) case of MRSA; however, there were 4 (31%) clindamycin-resistant SA isolates. CONCLUSION: Unlike previously published data, there was no increase in MRSA incidence at our institution. However, the high prevalence of clindamycin-resistant SA was in line with previous reports. These findings should be considered when starting empirical therapy in pediatric neck abscesses.
[Mh] Termos MeSH primário: Abscesso/microbiologia
Antibacterianos/uso terapêutico
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Meticilina/uso terapêutico
Infecções Estafilocócicas/epidemiologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Abscesso/tratamento farmacológico
Criança
Pré-Escolar
Feminino
Seres Humanos
Incidência
Lactente
Masculino
Prevalência
Estudos Retrospectivos
Infecções Estafilocócicas/tratamento farmacológico
Staphylococcus aureus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


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[PMID]:28797064
[Au] Autor:Mohammad H; Younis W; Ezzat HG; Peters CE; AbdelKhalek A; Cooper B; Pogliano K; Pogliano J; Mayhoub AS; Seleem MN
[Ad] Endereço:Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, United States of America.
[Ti] Título:Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus.
[So] Source:PLoS One;12(8):e0182821, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bacterial resistance to antibiotics remains an imposing global public health challenge. Of the most serious pathogens, methicillin-resistant Staphylococcus aureus (MRSA) is problematic given strains have emerged that exhibit resistance to several antibiotic classes including ß-lactams and agents of last resort such as vancomycin. New antibacterial agents composed of unique chemical scaffolds are needed to counter this public health challenge. The present study examines two synthetic diphenylurea compounds 1 and 2 that inhibit growth of clinically-relevant isolates of MRSA at concentrations as low as 4 µg/mL and are non-toxic to human colorectal cells at concentrations up to 128 µg/mL. Both compounds exhibit rapid bactericidal activity, completely eliminating a high inoculum of MRSA within four hours. MRSA mutants exhibiting resistance to 1 and 2 could not be isolated, indicating a low likelihood of rapid resistance emerging to these compounds. Bacterial cytological profiling revealed the diphenylureas exert their antibacterial activity by targeting bacterial cell wall synthesis. Both compounds demonstrate the ability to resensitize vancomycin-resistant Staphylococcus aureus to the effect of vancomycin. The present study lays the foundation for further investigation and development of diphenylurea compounds as a new class of antibacterial agents.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Carbanilidas/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Infecções Estafilocócicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Carbanilidas/uso terapêutico
Seres Humanos
Meticilina/farmacologia
Meticilina/uso terapêutico
Resistência a Meticilina/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Vancomicina/farmacologia
Vancomicina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carbanilides); 6Q205EH1VU (Vancomycin); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182821


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[PMID]:28693489
[Au] Autor:Adhikari RP; Shrestha S; Barakoti A; Amatya R
[Ad] Endereço:Department of Microbiology, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal. rampd11@yahoo.com.
[Ti] Título:Inducible clindamycin and methicillin resistant Staphylococcus aureus in a tertiary care hospital, Kathmandu, Nepal.
[So] Source:BMC Infect Dis;17(1):483, 2017 Jul 11.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Staphylococcus aureus, an important nosocomial pathogen, is frequently associated with infections in human. The management of the infections by it especially methicillin resistant ones is often difficult because methicillin resistant S. aureus is usually resistant to multiple antibiotics. Macrolide-lincosamide streptogramin B family of antibiotics is commonly used to treat such infections as an alternative to vancomycin. METHODS: This study was conducted over the period of one and half year from November 2013-April 2015 in Microbiology laboratory of Nepal Medical College and Teaching Hospital, Kathmandu, Nepal to find the incidence of different phenotypes of MLS resistance among S. aureus from clinical samples and their association with methicillin resistance. Two hundred seventy isolates of S. aureus were included in the study. Methicillin resistance was detected by cefoxitin disc diffusion method and inducible clindamycin resistance by erythromycin and clindamycin disc approximation test (D-test). RESULTS: Of the 270 clinical isolates of S. aureus, 25.1% (68/270) were MRSA. Erythromycin and clindamycin resistance was seen in 54.4% (147/270) and 41.8% (113/270) isolates respectively. Resistance to erythromycin and clindamycin were higher in MRSA as compared to MSSA (erythromycin-resistance: 88.2% Vs 39.1% and clindamycin-resistance: 79.4% Vs 41.8%). The overall prevalence of MLS and MLS phenotype was 11.48% (31/270) and 29.25% (79/270) respectively. Both MLS and MLS phenotypes predominated in MRSA strains. CONCLUSIONS: Detection rate of MRSA in our study shows the necessity to improve in healthcare practices and to formulate new policy for the control of MRSA infections. Clindamycin resistance in the form of MLS and MLS especially among MRSA emphasizes the need of D-test to be performed routinely in our set up while using clindamycin as an alternative choice to anti-staphylococcal antibiotics like vancomycin and linezolid in the treatment of staphylococcal infections.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Clindamicina/farmacologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Antibacterianos/uso terapêutico
Criança
Pré-Escolar
Clindamicina/uso terapêutico
Infecção Hospitalar/microbiologia
Estudos Transversais
Eritromicina/farmacologia
Eritromicina/uso terapêutico
Feminino
Seres Humanos
Lactente
Recém-Nascido
Macrolídeos/farmacologia
Macrolídeos/uso terapêutico
Masculino
Meticilina/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Testes de Sensibilidade Microbiana
Meia-Idade
Nepal/epidemiologia
Prevalência
Staphylococcus aureus/isolamento & purificação
Centros de Atenção Terciária
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Macrolides); 3U02EL437C (Clindamycin); 63937KV33D (Erythromycin); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2584-5


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[PMID]:28598307
[Au] Autor:Bhattacharya G; Dey D; Das S; Banerjee A
[Ad] Endereço:Ashok Laboratory Clinical Testing Centre Pvt. Ltd, 390 B Jodhpur Park, Kolkata-700068, West Bengal, India.
[Ti] Título:Exposure to sub-inhibitory concentrations of gentamicin, ciprofloxacin and cefotaxime induces multidrug resistance and reactive oxygen species generation in meticillin-sensitive Staphylococcus aureus.
[So] Source:J Med Microbiol;66(6):762-769, 2017 Jun.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The role of antibiotics below their MIC in the development of bacterial drug resistance is becoming increasingly important. We investigated the effect of sub-MICs of bactericidal antibiotics on the susceptibility pattern of Staphylococcus aureus and evaluated the role of free radicals. METHODOLOGY: A total of 12 S. aureus strains were recovered from pus samples and their antibiograms determined. The test isolates were treated with sub-MIC levels of tetracycline, gentamicin, ciprofloxacin and cefotaxime. Alterations in their respective breakpoints were observed along with measurements of free radical generation by nitro blue tetrazolium test.Results/Key findings. Gentamicin, ciprofloxacin and cefotaxime exposure significantly altered the breakpoints of exposed isolates against several tested antibiotics and higher levels of free radicals were generated after antibiotic exposure. CONCLUSIONS: Our study demonstrates that sub-MIC levels of antimicrobials can lead to resistance and cross-resistance across several classes of antibiotics in wild strains of S. aureus, possibly by free radical production. The molecular mechanisms behind the acquisition of drug resistance at low antibiotic concentrations and the specific target genes of reactive oxygen speciesneed to be explored further.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Cefotaxima/farmacologia
Ciprofloxacino/farmacologia
Farmacorresistência Bacteriana Múltipla
Gentamicinas/farmacologia
Seres Humanos
Meticilina/farmacologia
Testes de Sensibilidade Microbiana
Staphylococcus aureus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gentamicins); 0 (Reactive Oxygen Species); 5E8K9I0O4U (Ciprofloxacin); N2GI8B1GK7 (Cefotaxime); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000492


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[PMID]:28576638
[Au] Autor:Dupont J; Prat D; Sztrymf B
[Ad] Endereço:Réanimation polyvalente et surveillance continue, Hôpital Antoine béclère, Université Paris Sud, F-92140 Clamart, France.
[Ti] Título:Linezolid versus vancomycin in Methicillin Resistant Staphylococcus aureus nosocomial pneumonia in the elderly.
[So] Source:Am J Emerg Med;35(8):1197-1198, 2017 08.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Linezolida
Vancomicina
[Mh] Termos MeSH secundário: Acetamidas
Idoso
Antibacterianos
Infecção Hospitalar
Seres Humanos
Meticilina
Staphylococcus aureus Resistente à Meticilina
Oxazolidinonas
Pneumonia Estafilocócica
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Acetamides); 0 (Anti-Bacterial Agents); 0 (Oxazolidinones); 6Q205EH1VU (Vancomycin); ISQ9I6J12J (Linezolid); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


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[PMID]:28506332
[Au] Autor:Befus M; Mukherjee DV; Herzig CTA; Lowy FD; Larson E
[Ad] Endereço:Department of Epidemiology,Mailman School of Public Health, Columbia University,New York 10032,USA.
[Ti] Título:Correspondence analysis to evaluate the transmission of Staphylococcus aureus strains in two New York State maximum-security prisons.
[So] Source:Epidemiol Infect;145(10):2161-2165, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Prisons/jails are thought to amplify the transmission of Staphylococcus aureus (SA) particularly methicillin-resistant SA infection and colonisation. Two independently pooled cross-sectional samples of detainees being admitted or discharged from two New York State maximum-security prisons were used to explore this concept. Private interviews of participants were conducted, during which the anterior nares and oropharynx were sampled and assessed for SA colonisation. Log-binomial regression and correspondence analysis (CA) were used to evaluate the prevalence of colonisation at entry as compared with discharge. Approximately 51% of admitted (N = 404) and 41% of discharged (N = 439) female detainees were colonised with SA. Among males, 59% of those admitted (N = 427) and 49% of those discharged (N = 393) were colonised. Females had a statistically significant higher prevalence (1·26: P = 0·003) whereas males showed no significant difference (1·06; P = 0·003) in SA prevalence between entry and discharge. CA demonstrated that some strains, such as spa types t571 and t002, might have an affinity for certain mucosal sites. Contrary to our hypothesis, the prison setting did not amplify SA transmission, and CA proved to be a useful tool in describing the population structure of strains according to time and/or mucosal site.
[Mh] Termos MeSH primário: Prisioneiros
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/transmissão
Staphylococcus aureus/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meticilina/farmacologia
Resistência a Meticilina
Staphylococcus aureus Resistente à Meticilina/classificação
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/fisiologia
Meia-Idade
Cavidade Nasal/microbiologia
New York/epidemiologia
Orofaringe/microbiologia
Prevalência
Prisioneiros/estatística & dados numéricos
Prisões
Fatores de Risco
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/classificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
Q91FH1328A (Methicillin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000942


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[PMID]:28389090
[Au] Autor:Koivusalo M; Vermeiren C; Yuen J; Reeve C; Gadbois S; Katz K
[Ad] Endereço:North York General Hospital, Toronto, Ontario, Canada.
[Ti] Título:Canine scent detection as a tool to distinguish meticillin-resistant Staphylococcus aureus.
[So] Source:J Hosp Infect;96(1):93-95, 2017 05.
[Is] ISSN:1532-2939
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Staphylococcus aureus Resistente à Meticilina
Meticilina
[Mh] Termos MeSH secundário: Animais
Cães
Resistência a Meticilina
Infecções Estafilocócicas
Staphylococcus aureus
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T; COMMENT
[Nm] Nome de substância:
Q91FH1328A (Methicillin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE



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