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  1 / 7831 MEDLINE  
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[PMID]:28627373
[Au] Autor:Li M; Gehring R; Riviere JE; Lin Z
[Ad] Endereço:Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. Electronic address: miaoli@ksu.edu.
[Ti] Título:Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment.
[So] Source:Food Chem Toxicol;107(Pt A):74-87, 2017 Sep.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Penicillin G is a widely used antimicrobial in food-producing animals, and one of the most predominant drug residues in animal-derived food products. Due to reduced sensitivity of bacteria to penicillin, extralabel use of penicillin G is common, which may lead to violative residues in edible tissues and cause adverse reactions in consumers. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to predict drug residues in edible tissues and estimate extended withdrawal intervals for penicillin G in swine and cattle. A flow-limited PBPK model was developed with data from Food Animal Residue Avoidance Databank using Berkeley Madonna. The model predicted observed drug concentrations in edible tissues, including liver, muscle, and kidney for penicillin G both in swine and cattle well, including data not used in model calibration. For extralabel use (5× and 10× label dose) of penicillin G, Monte Carlo sampling technique was applied to predict times needed for tissue concentrations to fall below established tolerances for the 99th percentile of the population. This model provides a useful tool to predict tissue residues of penicillin G in swine and cattle to aid food safety assessment, and also provide a framework for extrapolation to other food animal species.
[Mh] Termos MeSH primário: Antibacterianos/farmacocinética
Resíduos de Drogas/farmacocinética
Carne/análise
Penicilina G/farmacocinética
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Bovinos
Resíduos de Drogas/química
Inocuidade dos Alimentos
Rim/química
Fígado/química
Modelos Biológicos
Músculo Esquelético/química
Penicilina G/química
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


  2 / 7831 MEDLINE  
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[PMID]:28522308
[Au] Autor:Lee AY; Ha NR; Jung IP; Kim SH; Kim AR; Yoon MY
[Ad] Endereço:Department of Chemistry and Research Institute of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea.
[Ti] Título:Development of a ssDNA aptamer for detection of residual benzylpenicillin.
[So] Source:Anal Biochem;531:1-7, 2017 Aug 15.
[Is] ISSN:1096-0309
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antibiotics are useful for improving the living conditions of livestock. However, residual antibiotics induce several human diseases such as food-borne illness and infection of carbapenem-resistant Enterobacteriaceae (CRE). In this study, the identification of a benzylpenicillin-specific aptamer was selected by rGO-SELEX (reduced Graphene Oxide-Systematic Evolution of Ligands by EXponential enrichment). A random ssDNA library was incubated with rGO for adsorption and eluted with benzylpenicillin. As a result of the selection process, a DNA aptamer was found that specifically bound to benzylpenicillin with high binding affinity, K = 383.4 nM, and had a low limit of detection (LOD) of 9.2 nM. The characterization of the aptamer was performed through the fluorescence recovery signal from rGO surface. In addition, detection of benzylpenicillin was performed in pretreated milk samples, and its detection accuracy was shown to be 100± 10%. This represented that BBA1 was used for fluorescence aptasensor system in real sample. Furthermore, this benzylpenicillin binding aptamer showed high specificity against other antibiotics except for ampicillin. With these advantageous characteristics, we expect that this aptamer could be applied to an on-site detection system for residual benzylpenicillin.
[Mh] Termos MeSH primário: Aptâmeros de Nucleotídeos/química
Aptâmeros de Nucleotídeos/síntese química
Penicilina G/análise
Técnica de Seleção de Aptâmeros/métodos
[Mh] Termos MeSH secundário: Fluorescência
Grafite
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aptamers, Nucleotide); 7782-42-5 (Graphite); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


  3 / 7831 MEDLINE  
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[PMID]:28415016
[Au] Autor:Duelge KJ; Nishshanka U; De Alwis HG
[Ad] Endereço:Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
[Ti] Título:An LC-MS/MS method for the determination of antibiotic residues in distillers grains.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1053:81-86, 2017 May 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Antibiotics are used in ethanol production to discourage the growth of bacteria that would result in lower ethanol content and a lower quality product. A survey conducted by the FDA (FY 2010 Nationwide Survey of Distillers Grains for Antibiotic Residues, 2009 [1]) revealed that the residues of these antibiotics can remain in the distillers grains (DG) by-product, which is used as an animal feed ingredient. The low levels of antibiotic residues in DG could be a public health concern, as they could lead to antimicrobial resistance. To enable the quantitative determination of these antibiotics (erythromycin, penicillin G, virginiamycin M1 and virginiamycin S1), we developed a sensitive LC-MS/MS method. The residues were extracted from distillers grains with a mixture of acetonitrile and buffer followed by acetonitrile. The combined extract was diluted with water and washed with hexane. An aliquot was cleaned up on an Oasis HLB solid phase extraction cartridge. Extracts were analyzed by LC-tandem mass spectrometry. The method was successfully validated using a variety of different matrices such as corn DG, corn & milo DG, and deoiled corn DG. Absolute recoveries of the analytes ranged from 53 to 106%. Accuracy ranged from 90 to 101% based on calibration by matrix standards. The limits of quantitation and relative standard deviation were all satisfactory to support future surveillance studies.
[Mh] Termos MeSH primário: Ração Animal/análise
Antibacterianos/análise
Eritromicina/análise
Penicilina G/análise
Estreptogramina A/análise
Estreptogramina Grupo B/análise
Espectrometria de Massas em Tandem/métodos
Virginiamicina/análise
[Mh] Termos MeSH secundário: Acetonitrilos/química
Animais
Cromatografia Líquida/métodos
Grãos Comestíveis/química
Hexanos/química
Limite de Detecção
Extração em Fase Sólida/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Anti-Bacterial Agents); 0 (Hexanes); 0 (Streptogramin Group B); 0 (virginiamycin factor S1); 11006-76-1 (Virginiamycin); 2DDG612ED8 (n-hexane); 63937KV33D (Erythromycin); 8W4UOL59AZ (Streptogramin A); Q42T66VG0C (Penicillin G); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE


  4 / 7831 MEDLINE  
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[PMID]:28389466
[Au] Autor:Miraclin AT; Perumalla SK; Daniel J; Sathyendra S
[Ad] Endereço:Department of General Medicine, Christian Medical College and Hospital, Vellore, India angel_miraclin@yahoo.com.
[Ti] Título: endarteritis with infective spondylodiscitis in an adult patient with patent ductus arteriosus.
[So] Source:BMJ Case Rep;2017, 2017 Apr 07.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Endarteritis is a major complication in patients with patent ductus arteriosus, causing significant morbidity and mortality. We report an adult patient with asymptomatic patent ductus arteriosus and endarteritis involving the main pulmonary artery and secondary infective spondylodiscitis at the L5-S1 intervertebral disc caused by , commonly referred to as nutritionally variant streptococci, cannot be identified easily by conventional blood culture techniques from clinical specimens. Its isolation was confirmed by 16S ribosomal RNA sequencing. The patient was successfully managed with a combination of penicillin G and gentamicin, pending surgical repair of the patent ductus arteriosus.
[Mh] Termos MeSH primário: Abiotrophia/isolamento & purificação
Discite/microbiologia
Endarterite/microbiologia
Infecções por Bactérias Gram-Positivas/diagnóstico
[Mh] Termos MeSH secundário: Abiotrophia/classificação
Abiotrophia/genética
Discite/tratamento farmacológico
Permeabilidade do Canal Arterial/complicações
Endarterite/tratamento farmacológico
Feminino
Infecções por Bactérias Gram-Positivas/tratamento farmacológico
Seres Humanos
Vértebras Lombares/microbiologia
Meia-Idade
Penicilina G/uso terapêutico
Sacro/microbiologia
Análise de Sequência de RNA
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE


  5 / 7831 MEDLINE  
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[PMID]:28334649
[Au] Autor:Chen X; Li Y; Zhang Y; Yang J; Bian L
[Ad] Endereço:College of Life Science, Northwest University, Xi'an 710069, PR China.
[Ti] Título:Binding of TEM-1 beta-lactamase to beta-lactam antibiotics by frontal affinity chromatography.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1051:75-83, 2017 Apr 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:TEM-1 beta-lactamases can accurately catalyze the hydrolysis of the beta-lactam rings in beta-lactam antibiotics, which make beta-lactam antibiotics lose its activity, and the prerequisite for the hydrolysis procedure in the binding interaction of TEM-1 beta-lactamases with beta-lactam antibiotics is the beta-lactam rings in beta-lactam antibiotics. Therefore, the binding of TEM-1 beta-lactamase to three beta-lactam antibiotics including penicillin G, cefalexin as well as cefoxitin was explored here by frontal affinity chromatography in combination with fluorescence spectra, adsorption and thermodynamic data in the temperature range of 278-288K under simulated physiological conditions. The results showed that all the binding of TEM-1 beta-lactamase to the three antibiotics were spontaneously exothermic processes with the binding constants of 8.718×10 , 6.624×10 and 2.244×10 (mol/L), respectively at 288K. All the TEM-1 beta-lactamases were immobilized on the surface of the stationary phase in the mode of monolayer and there existed only one type of binding sites on them. Each TEM-1 beta-lactamase bound with only one beta-lactam antibiotic and hydrogen bond interaction and Van der Waals force were the main forces between them. This work provided an insight into the binding interactions between TEM-1 beta-lactamases and beta-lactam antibiotics, which may be beneficial for the designing and developing of new substrates resistant to TEM-1 beta-lactamases.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Cromatografia de Afinidade/métodos
Bactérias Gram-Negativas/enzimologia
beta-Lactamases/metabolismo
beta-Lactamas/metabolismo
[Mh] Termos MeSH secundário: Cefoxitina/metabolismo
Cefalexina/metabolismo
Enzimas Imobilizadas/metabolismo
Bactérias Gram-Negativas/metabolismo
Penicilina G/metabolismo
Ligação Proteica
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Enzymes, Immobilized); 0 (beta-Lactams); 6OEV9DX57Y (Cefoxitin); EC 3.5.2.6 (beta-Lactamases); EC 3.5.2.6 (beta-lactamase TEM-1); OBN7UDS42Y (Cephalexin); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE


  6 / 7831 MEDLINE  
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[PMID]:28288165
[Au] Autor:Peng RR; Wu J; Zhao W; Qi T; Shi M; Guan Z; Lu H; Long F; Gao Z; Zhang S; Zhou P
[Ad] Endereço:Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, Shanghai, People's Republic of China.
[Ti] Título:Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?
[So] Source:PLoS Negl Trop Dis;11(3):e0005456, 2017 Mar.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin when treating other diseases. This study aimed to investigate the incidence, presentation, management and prognosis of benzylpenicillin-induced neutropenia in treating neurosyphilis based on a large sample of syphilis patients in Shanghai. METHODOLOGY/PRINCIPAL FINDINGS: Between 1st January 2013 and 31st December 2015, 1367 patients with neurosyphilis were treated with benzylpenicillin, 578 of whom were eligible for recruitment to this study. Among patients without medical co-morbidities, the total incidence of benzylpenicillin-induced neutropenia and severe neutropenia was 2.42% (95% CI: 1.38-4.13%) and 0.35% (95% CI: 0.06-1.39%), respectively. The treatment duration before onset of neutropenia ranged from 10 to 14 days, with a total cumulative dose of between 240 and 324 megaunits of benzylpenicillin. Neutropenia was accompanied by symptoms of chills and fever (5 patients), fatigue (2 patients), cough (1 patient), sore throat (1 patient), diarrhea (1 patient) and erythematous rash (1 patient). The severity of neutropenia was not associated with age, gender or type of neurosyphilis (p>0.05). Neutropenia, even when severe, was often tolerated and normalized within one week. A more serious neutropenia did not occur when reinstituting benzylpenicillin in patients with mild or moderate neutropenia nor when ceftriaxone was used three months after patients had previously experienced severe neutropenia. CONCLUSIONS/SIGNIFICANCE: Benzylpenicillin-induced neutropenia was uncommon in our cohort of patients. Continuation of therapy was possible with intensive surveillance for those with mild or moderate neutropenia. For severe neutropenia, it is not essential to aggressively use hematopoietic growth factors or broad-spectrum antibiotics for patients in good physical condition after withdrawing anti-neurosyphilis regimen. We did not see an exacerbation of neutropenia in patients with the readministration of benzylpenicillin.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Neurossífilis/complicações
Neurossífilis/tratamento farmacológico
Neutropenia/induzido quimicamente
Neutropenia/epidemiologia
Penicilina G/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/administração & dosagem
China/epidemiologia
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Neutropenia/patologia
Penicilina G/administração & dosagem
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005456


  7 / 7831 MEDLINE  
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[PMID]:28246419
[Au] Autor:Gordon DL; Radtke CL
[Ad] Endereço:Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.
[Ti] Título:Treatment of chronic sinusitis in a horse with systemic and intra-sinus antimicrobials.
[So] Source:Can Vet J;58(3):289-292, 2017 Mar.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:A 12-year-old Norwegian Fjord gelding was diagnosed with paranasal sinusitis as a post-operative complication of tooth repulsion surgery. The infection with inspissated purulent material persisted despite sinus trephination and lavage, and systemic antimicrobial therapy. Resolution occurred following infusion of a gelatin/penicillin mixture into the right rostral and caudal maxillary sinus.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Penicilina G/administração & dosagem
Complicações Pós-Operatórias/veterinária
Sinusite/veterinária
[Mh] Termos MeSH secundário: Animais
Cavalos
Masculino
Complicações Pós-Operatórias/tratamento farmacológico
Complicações Pós-Operatórias/microbiologia
Sinusite/tratamento farmacológico
Extração Dentária/veterinária
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


  8 / 7831 MEDLINE  
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[PMID]:28231527
[Au] Autor:Lê LM; Eveleigh L; Hasnaoui I; Prognon P; Baillet-Guffroy A; Caudron E
[Ad] Endereço:Lip(Sys)(2) Chimie Analytique Pharmaceutique, Univ. Paris-Sud, Université Paris-Saclay (EA4041 Groupe de Chimie Analytique de Paris-Sud), F-92290 Châtenay-Malabry, France; Pharmacy Department, European Georges Pompidou Hospital, Assistance Publique des Hôpitaux de Paris, 75015 Paris, France. Electro
[Ti] Título:Rapid discrimination and determination of antibiotics drugs in plastic syringes using near infrared spectroscopy with chemometric analysis: Application to amoxicillin and penicillin.
[So] Source:J Pharm Biomed Anal;138:249-255, 2017 May 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate near infrared spectroscopy (NIRS) combined to chemometric analysis to discriminate and quantify three antibiotics by direct measurement in plastic syringes.Solutions of benzylpenicillin (PENI), amoxicillin (AMOX) and amoxicillin/clavulanic acid (AMOX/CLAV) were analyzed at therapeutic concentrations in glass vials and plastic syringes with NIR spectrometer by direct measurement. Chemometric analysis using partial least squares regression and discriminative analysis was conducted to develop qualitative and quantitative calibration models. Discrimination of the three antibiotics was optimal for concentrated solutions with 100% of accuracy. For quantitative analysis, the three antibiotics furnished a linear response (R²>0.9994) for concentrations ranging from 0.05 to 0.2 g/mL for AMOX, 0.1 to 1.0 MUI/mL for PENI and 0.005 to 0.05 g/mL for AMOX/CLAV with excellent repeatability (maximum 1.3%) and intermediate precision (maximum of 3.2%). Based on proposed models, 94.4% of analyzed AMOX syringes, 80.0% of AMOX/CLAV syringes and 85.7% of PENI syringes were compliant with a relative error including the limit of ± 15%.NIRS as rapid, non-invasive and non-destructive analytical method represents a potentially powerful tool to further develop for securing the drug administration circuit of healthcare institutions to ensure that patients receive the correct product at the right dose.
[Mh] Termos MeSH primário: Amoxicilina/química
Antibacterianos/química
Penicilinas/química
[Mh] Termos MeSH secundário: Combinação Amoxicilina e Clavulanato de Potássio/química
Calibragem
Análise dos Mínimos Quadrados
Penicilina G/química
Espectroscopia de Luz Próxima ao Infravermelho/métodos
Seringas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Penicillins); 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination); 804826J2HU (Amoxicillin); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


  9 / 7831 MEDLINE  
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[PMID]:28205436
[Au] Autor:Shelver WL; Chakrabarty S; Smith DJ
[Ad] Endereço:Agricultural Research Service, Biosciences Research Laboratory, United States Department of Agriculture , 1605 Albrecht Boulevard, Fargo, North Dakota 58102-2765, United States.
[Ti] Título:Comparison of Lateral Flow Assay, Kidney Inhibition Swab, and Liquid Chromatography-Tandem Mass Spectrometry for the Detection of Penicillin G Residues in Sow Urine.
[So] Source:J Agric Food Chem;65(8):1778-1783, 2017 Mar 01.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sows (n = 126) were administered penicillin G; urine, collected at slaughter, was screened by kidney inhibition swab (KIS; 4 h testing time) and then stored at -80 °C (∼1200 days) until analysis by lateral flow assay (LF, ∼5 min testing time) and tandem quadrupole LC-MS/MS (TQ) analysis. The stability of penicillin in urine during storage was verified using TQ analyses. Quantitative results were well-correlated (R = 0.98) with only a ∼10% decrease in penicillin concentration during the 3-year storage period. KIS retesting of stored samples returned results consistent with the original analyses. Lateral flow assay results were highly correlated with the KIS and TQ results. A KIS positive sample, which was not confirmed by TQ or LF, was assayed by Triple-TOF LC-MS to determine the cause of the apparent false positive. This study suggests LF can be used to quickly and efficiently screen for penicillin G residues before slaughter.
[Mh] Termos MeSH primário: Antibacterianos/urina
Cromatografia Líquida de Alta Pressão/métodos
Imunoensaio/métodos
Penicilina G/urina
Suínos/urina
[Mh] Termos MeSH secundário: Animais
Resíduos de Drogas/análise
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b05049


  10 / 7831 MEDLINE  
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[PMID]:28192580
[Au] Autor:Triemstra J; Reno K; Chohlas-Wood R; Nash C
[Ti] Título:A Brief Resolved Unexplained Event and Congenital Neurosyphilis.
[So] Source:Pediatr Ann;46(2):e61-e64, 2017 Feb 01.
[Is] ISSN:1938-2359
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brief resolved unexplained event (BRUE) is a common pediatric problem that presents to ambulatory and emergency settings. Infants presenting with a BRUE can be separated into low- and high-risk groups per recent guidelines. Most low-risk infants who present with a BRUE can be discharged home with anticipatory guidance and education provided to the caregivers; however, high-risk infants should undergo further testing and observation to determine the cause of their event. Congenital neurosyphilis can be a rare cause of a BRUE. Therefore, high-risk infants with a BRUE should have evaluations focused on potential diagnosis supported by the patient's history and physical examination. [Pediatr Ann. 2017;46(2):e61-e64.].
[Mh] Termos MeSH primário: Sintomas Inexplicáveis
Neurossífilis/congênito
Neurossífilis/diagnóstico
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Diagnóstico Diferencial
Seres Humanos
Lactente
Recém-Nascido
Infusões Intravenosas
Masculino
Neurossífilis/tratamento farmacológico
Penicilina G/administração & dosagem
Fatores de Risco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); Q42T66VG0C (Penicillin G)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.3928/19382359-20170118-02



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