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[PMID]:26823174
[Au] Autor:Ren J; Nettleship JE; Males A; Stuart DI; Owens RJ
[Ad] Endereço:Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford, UK.
[Ti] Título:Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
[So] Source:FEBS Lett;590(2):288-97, 2016 Jan.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Penicillin-binding protein 3 (PBP3) from Pseudomonas aeruginosa is the molecular target of ß-lactam-based antibiotics. Structures of PBP3 in complexes with azlocillin and cefoperazone, which are in clinical use for the treatment of pseudomonad infections, have been determined to 2.0 Å resolution. Together with data from other complexes, these structures identify a common set of residues involved in the binding of ß-lactams to PBP3. Comparison of wild-type and an active site mutant (S294A) showed that increased thermal stability of PBP3 following azlocillin binding was entirely due to covalent binding to S294, whereas cefoperazone binding produces some increase in stability without the covalent link. Consistent with this, a third crystal structure was determined in which the hydrolysis product of cefoperazone was noncovalently bound in the active site of PBP3. This is the first structure of a complex between a penicillin-binding protein and cephalosporic acid and may be important in the design of new noncovalent PBP3 inhibitors.
[Mh] Termos MeSH primário: Azlocilina/química
Cefoperazona/química
Proteínas de Ligação às Penicilinas/química
[Mh] Termos MeSH secundário: Acilação
Cristalografia por Raios X
Modelos Moleculares
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Penicillin-Binding Proteins); 7U75I1278D (Cefoperazone); HUM6H389W0 (Azlocillin)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12054


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[PMID]:24819365
[Au] Autor:Nair DG; Narayanan SP; Chittalakkottu S
[Ad] Endereço:a Department of Biotechnology and Microbiology , Kannur University , Thalassery Campus, Palayad P.O., Kannur , Kerala 670661 , India.
[Ti] Título:Interactions of some commonly used drugs with human α-thrombin.
[So] Source:J Biomol Struct Dyn;33(5):1008-15, 2015.
[Is] ISSN:1538-0254
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adverse side effects of drugs are often caused by the interaction of drug molecules to targets other than the intended ones. In this study, we investigated the off-target interactions of some commercially available drugs with human α-thrombin. The drugs used in the study were selected from Super Drug Database based on the structural similarity to a known thrombin inhibitor argatroban. Interactions of these drugs with thrombin were initially checked by in silico docking studies and then confirmed by thrombin inhibition assay using a fluorescence microplate-based method. Results show that the three commonly used drugs piperacillin (anti-bacterial), azlocillin (anti-bacterial), and metolazone (anti-hypertensive and diuretic) have thrombin inhibitory activity almost similar to that of argatroban. The Ki values of piperacillin, azlocillin, and metolazone with thrombin are .55, .95, and .62 nM, respectively. The IC50 values of piperacillin, azlocillin, and metolazone with thrombin are 1.7, 2.9, and 1.92 nM, respectively. This thrombin inhibitory activity might be a reason for the observed side effects of these drugs related to blood coagulation and other thrombin activities. Furthermore, these compounds (drugs) may be used as anti-coagulants as such or with structural modifications.
[Mh] Termos MeSH primário: Antitrombinas/química
Simulação de Acoplamento Molecular
Ácidos Pipecólicos/química
Trombina/química
[Mh] Termos MeSH secundário: Antitrombinas/metabolismo
Azlocilina/química
Azlocilina/metabolismo
Seres Humanos
Cinética
Metolazona/química
Metolazona/metabolismo
Estrutura Molecular
Ácidos Pipecólicos/metabolismo
Piperacilina/química
Piperacilina/metabolismo
Ligação Proteica
Estrutura Terciária de Proteína
Trombina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antithrombins); 0 (Pipecolic Acids); EC 3.4.21.5 (Thrombin); HUM6H389W0 (Azlocillin); IY90U61Z3S (argatroban); TZ7V40X7VX (Metolazone); X00B0D5O0E (Piperacillin)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140514
[St] Status:MEDLINE
[do] DOI:10.1080/07391102.2014.923329


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[PMID]:21360610
[Au] Autor:Asandei A; Apetrei A; Luchian T
[Ad] Endereço:Faculty of Physics, Laboratory of Biophysics and Medical Physics, Alexandru I. Cuza' University, Blvd. Carol I, No. 11, Iasi R-700506, Romania.
[Ti] Título:Uni-molecular detection and quantification of selected ß-lactam antibiotics with a hybrid α-hemolysin protein pore.
[So] Source:J Mol Recognit;24(2):199-207, 2011 Mar-Apr.
[Is] ISSN:1099-1352
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Single-nanopores have recently been used to electrically detect a wide range of analytes. Similarly, using electrophysiology, we demonstrate how a system comprised of an ion channel formed by α-hemolysin (α-HL) and single-cyclic γ-cyclodextrin (γ-CD) molecule permits the detection of, and differentiation between three different antibiotics from the ß-lactam family. Specifically, histograms of the time between the successive binding events, and the residence time distributions of the antibiotic in the γ-CD molecular adapter vary with the antibiotic type. The results show that the association times of amoxicillin, azlocillin, and ampicillin are τ(on) = 2.1 ± 0.2, 2.2 ± 0.3, and 3.1 ± 0.4 ms, respectively. Interestingly, we found that the residence time of the bulkier and negatively charged azlocillin (τ(off) = 0.008 ± 0.0005 ms) is much less than that of ampicillin (τ(off) = 0.07 ± 0.005 ms) and amoxicillin (τ(off) = 0.1 ± 0.02 ms), even though the γ-CD-α-HL complex is anionic selective. The data were also used to estimate the standard free energy of binding between ampicillin to γ-CDs binding (-12 kJ mol(-1) [corrected]). The difference in association times might be due to γ-CDs-imposed steric hindrance or an energetically more expensive desolvation step for the antibiotics to gain access to the binding site in the CD. We suggest that this technique may be used to detect other analytes used in pharmaceutical applications.
[Mh] Termos MeSH primário: Antibacterianos/análise
Proteínas Hemolisinas/química
Técnicas de Sonda Molecular
Proteínas Recombinantes/química
beta-Lactamas/análise
[Mh] Termos MeSH secundário: Amoxicilina/análise
Amoxicilina/química
Ampicilina/análise
Ampicilina/química
Antibacterianos/química
Azlocilina/análise
Azlocilina/química
Eletricidade
Ativação do Canal Iônico
Cinética
Nanoporos
Processos Estocásticos
Fatores de Tempo
beta-Lactamas/química
gama-Ciclodextrinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hemolysin Proteins); 0 (Recombinant Proteins); 0 (beta-Lactams); 0 (gamma-Cyclodextrins); 7C782967RD (Ampicillin); 804826J2HU (Amoxicillin); HUM6H389W0 (Azlocillin); KZJ0BYZ5VA (gamma-cyclodextrin)
[Em] Mês de entrada:1106
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110302
[St] Status:MEDLINE
[do] DOI:10.1002/jmr.1038


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[PMID]:21219695
[Au] Autor:Peres RL; Palaci M; Loureiro RB; Dietze R; Johnson JL; Maciel EL
[Ad] Endereço:Center for Infectious Diseases, Federal University of Espírito Santo, Vitória, Brazil.
[Ti] Título:Reduction of contamination of mycobacterial growth indicator tubes using increased PANTA concentration.
[So] Source:Int J Tuberc Lung Dis;15(2):281-3, i, 2011 Feb.
[Is] ISSN:1815-7920
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:We assessed the effect of a double concentration of supplemental polymyxin B, amphotericin B, nalidixic acid, trimethoprim and azlocillin (PANTA) added to the Mycobacterial Growth Indicator Tube (MGIT) on contamination and positivity rates in 216 sputum cultures. Contamination rates were respectively 12.9% and 5.5% for samples processed using standard and double PANTA concentrations (P = 0.0001, McNemar's test). Thirty-five per cent of cultures performed using standard PANTA and 36.5% of those performed using two-fold PANTA concentrations were positive for Mycobacterium tuberculosis, compared to 25.9% of cultures inoculated on Ogawa medium. These results suggest that the use of MGIT with 2× PANTA may be useful in reducing culture contamination without reducing the diagnostic yield.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Técnicas Bacteriológicas/instrumentação
Equipamentos Descartáveis/microbiologia
Contaminação de Equipamentos/prevenção & controle
Mycobacterium tuberculosis/isolamento & purificação
Escarro/microbiologia
Tuberculose Pulmonar/diagnóstico
[Mh] Termos MeSH secundário: Anfotericina B/farmacologia
Azlocilina/farmacologia
Meios de Cultura
Relação Dose-Resposta a Droga
Seres Humanos
Mycobacterium tuberculosis/crescimento & desenvolvimento
Ácido Nalidíxico/farmacologia
Polimixina B/farmacologia
Valor Preditivo dos Testes
Estudos Prospectivos
Trimetoprima/farmacologia
Tuberculose Pulmonar/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Culture Media); 1404-26-8 (Polymyxin B); 3B91HWA56M (Nalidixic Acid); 7XU7A7DROE (Amphotericin B); AN164J8Y0X (Trimethoprim); HUM6H389W0 (Azlocillin)
[Em] Mês de entrada:1104
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110112
[St] Status:MEDLINE


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[PMID]:20573263
[Au] Autor:Polihronakis M; Caterino MS
[Ad] Endereço:Department of Invertebrate Zoology, Santa Barbara Museum of Natural History, 2559 Puesta del Sol Rd, Santa Barbara, CA 93105, USA.
[Ti] Título:Contrasting patterns of phylogeographic relationships in sympatric sister species of ironclad beetles (Zopheridae: Phloeodes spp.) in California's Transverse Ranges.
[So] Source:BMC Evol Biol;10:195, 2010 Jun 24.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Comparative phylogeography of sympatric sibling species provides an opportunity to isolate the effects of geography and demographics on the evolutionary history of two lineages over the same, known time scale. In the current study, we investigated the phylogeographic structure of two zopherid beetle species, Phloeodes diabolicus and P. plicatus, where their ranges overlap in California's Transverse Ranges. RESULTS: Although P. diabolicus and P. plicatus share similar habitats with largely overlapping distributions, the results of this study revealed different evolutionary histories for each species since divergence from their most recent common ancestor. In general, P. plicatus had higher genetic diversity, and more among population isolation than P. diabolicus. The mismatch distributions indicated that one major difference between the two species was the timing of population expansion. This result was consistent with genetic patterns revealed by the Phist values and genetic diversity. Lastly, there were no parallel genetic breaks at similar geographic barriers between the species. CONCLUSIONS: Our data revealed that differential demographics rather than geography were responsible for the genetic patterns of the two species.
[Mh] Termos MeSH primário: Coleópteros/genética
Evolução Molecular
Variação Genética
Filogenia
[Mh] Termos MeSH secundário: Animais
Azlocilina
California
Coleópteros/classificação
Ecossistema
Genética Populacional
Geografia
Modelos Genéticos
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
HUM6H389W0 (Azlocillin)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100625
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2148-10-195


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[PMID]:20561192
[Au] Autor:Mao XG; Zhu GJ; Zhang S; Rossiter SJ
[Ad] Endereço:School of Life Science, East China Normal University, Shanghai 200062, China.
[Ti] Título:Pleistocene climatic cycling drives intra-specific diversification in the intermediate horseshoe bat (Rhinolophus affinis) in Southern China.
[So] Source:Mol Ecol;19(13):2754-69, 2010 Jul.
[Is] ISSN:1365-294X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The repeated formation and loss of land-bridges during the Pleistocene have had lasting impacts on population genetic structure. In the tropics, where island populations persisted through multiple glacial cycles, alternating periods of isolation and contact are expected to have driven population and taxonomic divergence. Here, we combine mitochondrial and nuclear sequence data with microsatellites to dissect the impact of Pleistocene climate change on intra-specific diversification in the horseshoe bat Rhinolophus affinis. This taxon shows considerable morphological and acoustic variation: two parapatric subspecies (himalayanus and macrurus) occur on mainland China and a third (hainanus) on Hainan Island. Our phylogeographic reconstruction and coalescent analyses suggest the island subspecies formed from an ancestral population of himalayanus via two colonization events c. 800,000 years before present. R. a. hainanus then recolonized the mainland, forming macrurus and thus a secondary contact zone with himalayanus. Finally, macrurus recolonized Hainan following the LGM. We found that all three biological events corresponded to known periods of land-bridge formation. Evidence of introgression was detected between macrurus and both its sister taxa, with geographical proximity rather than length of separation appearing to be the biggest determinant of subsequent genetic exchange. Our study highlights the important role of climate-mediated sea level changes have had in shaping current processes and patterns of population structure and taxonomic diversification.
[Mh] Termos MeSH primário: Quirópteros/genética
Clima
Evolução Molecular
Genética Populacional
[Mh] Termos MeSH secundário: Animais
Azlocilina
Núcleo Celular/genética
China
Quirópteros/classificação
Análise por Conglomerados
DNA Mitocondrial/genética
Feminino
Fluxo Gênico
Especiação Genética
Variação Genética
Genótipo
Geografia
Repetições de Microssatélites
Filogenia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial); HUM6H389W0 (Azlocillin)
[Em] Mês de entrada:1009
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100622
[St] Status:MEDLINE
[do] DOI:10.1111/j.1365-294X.2010.04704.x


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[PMID]:20399872
[Au] Autor:Byrne M; Rowe F; Uthicke S
[Ad] Endereço:Schools of Medical and Biological Sciences, F13, University of Sydney, NSW 2006, Australia. mbyrne@anatomy.usyd.edu.au
[Ti] Título:Molecular taxonomy, phylogeny and evolution in the family Stichopodidae (Aspidochirotida: Holothuroidea) based on COI and 16S mitochondrial DNA.
[So] Source:Mol Phylogenet Evol;56(3):1068-81, 2010 Sep.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Stichopodidae comprise a diverse assemblage of holothuroids most of which occur in the Indo-Pacific. Phylogenetic analyses of mitochondrial gene (COI, 16S rRNA) sequence for 111 individuals (7 genera, 17 species) clarified taxonomic uncertainties, species relationships, biogeography and evolution of the family. A monophyly of the genus Stichopus was supported with the exception of Stichopus ellipes. Molecular analyses confirmed genus level taxonomy based on morphology. Most specimens harvested as S. horrens fell in the S. monotuberculatus clade, a morphologically variable assemblage with others from the S. naso clade. Taxonomic clarification of species fished as S. horrens will assist conservation measures. Evolutionary rates based on comparison of sequence from trans-ithmian Isostichopus species estimated that Stichopus and Isostichopus diverged ca. 5.5-10.7Ma (Miocene). More recent splits were estimated to be younger than 1Ma.
[Mh] Termos MeSH primário: Evolução Molecular
Filogenia
Pepinos-do-Mar/classificação
[Mh] Termos MeSH secundário: Animais
Azlocilina
DNA Mitocondrial/genética
Haplótipos
Funções Verossimilhança
Modelos Genéticos
Reprodução
Pepinos-do-Mar/anatomia & histologia
Pepinos-do-Mar/genética
Análise de Sequência de DNA
Stichopus/anatomia & histologia
Stichopus/classificação
Stichopus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial); HUM6H389W0 (Azlocillin)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100420
[St] Status:MEDLINE
[do] DOI:10.1016/j.ympev.2010.04.013


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[PMID]:19238709
[Au] Autor:Yannic G; Basset P; Hausser J
[Ad] Endereço:Department of Ecology and Evolution, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland. glenn.yannic@gmail.com
[Ti] Título:Phylogeography and recolonization of the Swiss Alps by the Valais shrew (Sorex antinorii), inferred with autosomal and sex-specific markers.
[So] Source:Mol Ecol;17(18):4118-33, 2008 Sep.
[Is] ISSN:0962-1083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Using one male-inherited, one female-inherited and eight biparentally inherited markers, we investigate the population genetic structure of the Valais shrew (Sorex antinorii) in the Swiss Alps. Bayesian analysis on autosomal microsatellites suggests a clear genetic differentiation between two groups of populations. This geographically based structure is consistent with two separate postglacial recolonization routes of the species into Switzerland from Italian refugia after the last Pleistocene glaciations. Sex-specific markers also confirm genetic structuring among western and eastern areas, since very few haplotypes for either Y chromosome or mtDNA genome are shared between the two regions. Overall, these results suggest that two already well-differentiated genetic lineages colonized the Swiss Alps and came into secondary contact in the Rhône Valley. Low level of admixture between the two lineages is likely explained by the mountainous landscape structure of lateral valleys orthogonal to the main Rhône valley.
[Mh] Termos MeSH primário: Genética Populacional
Filogenia
Musaranhos/genética
[Mh] Termos MeSH secundário: Animais
Azlocilina
Análise por Conglomerados
DNA Mitocondrial/genética
Evolução Molecular
Feminino
Marcadores Genéticos
Geografia
Haplótipos
Padrões de Herança
Masculino
Repetições de Microssatélites
Modelos Genéticos
Polimorfismo Genético
Análise de Sequência de DNA
Suíça
Cromossomo Y/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (Genetic Markers); HUM6H389W0 (Azlocillin)
[Em] Mês de entrada:0903
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090225
[St] Status:MEDLINE


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[PMID]:17178445
[Au] Autor:Oulianova N; Cheng D; Huebert N; Chen Y
[Ad] Endereço:Biotechnology Research Institute, National Council of Canada, 6100 Royalmount, Montreal, Quebec H4P 2R2, Canada.
[Ti] Título:Human oral drugs absorption is correlated to their in vitro uptake by brush border membrane vesicles.
[So] Source:Int J Pharm;336(1):115-21, 2007 May 04.
[Is] ISSN:0378-5173
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Brush border membrane vesicles (BBMV) were prepared from the rabbit small intestine for testing drug absorption potency through the enterocyte's apical membrane, which is an important compartment for drug oral absorption. Some modifications have been made to the traditional vesicle assay for adapting it to the 96-well plate format. The accumulation of 23 reference drugs was measured, and the data showed a good correlation with human oral absorption with a correlation coefficient R=0.853 (P<0.001), with the exception of a few false positive results. As the measured drug absorption may contain a membrane/protein binding component as well as drug uptake into vesicles, these two fractions can be discriminated by changing extravesicular osmolarity using different mannitol concentrations. This model can be applied for evaluating drug absorption rate/mechanisms, and helping drug selection in early drug research and development.
[Mh] Termos MeSH primário: Absorção Intestinal
Mucosa Intestinal/metabolismo
Preparações Farmacêuticas/metabolismo
[Mh] Termos MeSH secundário: Acetaminofen/administração & dosagem
Acetaminofen/farmacocinética
Administração Oral
Animais
Azlocilina/administração & dosagem
Azlocilina/farmacocinética
Transporte Biológico Ativo
Cefadroxila/administração & dosagem
Cefadroxila/farmacocinética
Doxorrubicina/administração & dosagem
Doxorrubicina/farmacocinética
Seres Humanos
Concentração de Íons de Hidrogênio
Técnicas In Vitro
Intestino Delgado/metabolismo
Lamivudina/administração & dosagem
Lamivudina/farmacocinética
Manitol/química
Concentração Osmolar
Ouabaína/administração & dosagem
Ouabaína/farmacocinética
Preparações Farmacêuticas/administração & dosagem
Farmacocinética
Fenolsulfonaftaleína/administração & dosagem
Fenolsulfonaftaleína/farmacocinética
Coelhos
Zidovudina/administração & dosagem
Zidovudina/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 280111G160 (Cefadroxil); 2T8Q726O95 (Lamivudine); 362O9ITL9D (Acetaminophen); 3OWL53L36A (Mannitol); 4B9XT59T7S (Zidovudine); 5ACL011P69 (Ouabain); 80168379AG (Doxorubicin); HUM6H389W0 (Azlocillin); I6G9Y0J1OJ (Phenolsulfonphthalein)
[Em] Mês de entrada:0706
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061221
[St] Status:MEDLINE


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[PMID]:23427437
[Au] Autor:Pérez Monrás MF; Batlle Almodóvar Mdel C; González C; Tamargo Martínez I; Meneses FD
[Ad] Endereço:Instituto de Medicina Tropical Pedro Kouri. miriamp@ipk.sld.cu
[Ti] Título:[Meningoencephalitis caused by Pseudomonas cepacia].
[Ti] Título:Meningoencefalitis por Pseudomonas cepacia..
[So] Source:Rev Cubana Med Trop;58(2):162-4, 2006 May-Aug.
[Is] ISSN:0375-0760
[Cp] País de publicação:Cuba
[La] Idioma:spa
[Ab] Resumo:A case of meningoencephalitis of bacterial etiology caused by Pseudomonas cepacia was described. The strain was received at the Reference Laboratory of Bacterial Acute Respiratory Infections of "Pedro Kouri" Institute of Tropical Medicine, where its microbiological identification was confirmed. This isolation was a finding in an adult immunocompetent patient. The evolution was favourable with no sequelae for his future life. Pseudomona cepacia has been associated with respiratory infections in patients with cystic fibrosis. Patients with Pseudomonas cepacia may be asymptomatic or present fatal acute and fulminant infection.
[Mh] Termos MeSH primário: Infecções por Burkholderia/microbiologia
Burkholderia cepacia/isolamento & purificação
Infecções Comunitárias Adquiridas/microbiologia
Meningoencefalite/microbiologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Azlocilina/farmacologia
Aztreonam/uso terapêutico
Burkholderia cepacia/efeitos dos fármacos
Farmacorresistência Bacteriana Múltipla
Seres Humanos
Imunocompetência
Masculino
Meia-Idade
Ticarcilina/farmacologia
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); F93UJX4SWT (Ticarcillin); G2B4VE5GH8 (Aztreonam); HUM6H389W0 (Azlocillin)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130223
[St] Status:MEDLINE



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