Base de dados : MEDLINE
Pesquisa : D02.065.884.725.755 [Categoria DeCS]
Referências encontradas : 2222 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 223 ir para página                         

  1 / 2222 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29216620
[Au] Autor:Graves RA; Phan KV; Bostanian LA; Mandal TK; Pramar YV
[Ad] Endereço:College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana.
[Ti] Título:Physicochemical Stability of an Oral Suspension of Trimethoprim 20 mg/mL in Combination with Sulfadiazine 200 mg/mL in PCCA Base SuspendIt.
[So] Source:Int J Pharm Compd;21(5):430-435, 2017 Sep-Oct.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Trimethoprim is a diaminopyrimidine antibacterial agent that, like sulfonamides, inhibits bacterial folic acid synthesis, but at a different stage in the metabolic pathway. It has a similar spectrum of activity to the sulfonamides and is given by mouth or by injection, either alone or in conjunction with a sulfonamide, such as sulfadiazine. Sulfadiazine is a bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. The combination of the two drugs produces a synergistic effect against both Gram-positive and Gram-negative aerobic bacteria, by inhibiting enzymes in the folic acid pathways, which in turn inhibits bacterial thymidine synthesis. There are no published studies of the stability of the combination of trimethoprim and sulfadiazine in a liquid dosage form. An extemporaneously compounded suspension from pure drug powders or commercial tablets would provide an alternative option to meet unique patient needs. The purpose of this study was to determine the physicochemical stability of trimethoprim combined with sulfadiazine in PCCA base SuspendIt. PCCA base SuspendIt is a sugar-free, paraben-free, dye-free, and gluten-free thixotropic vehicle containing a natural sweetener obtained from the monk fruit. It thickens upon standing to minimize settling of any insoluble drug particles and becomes fluid upon shaking to allow convenient pouring during administration to the patient. A robust stability-indicating high-performance liquid chromatographic assay for the simultaneous determination of trimethoprim and sulfadiazine in SuspendIt was developed and validated. This assay was used to determine the chemical stability of both drugs in SuspendIt. Samples were prepared and stored under three different temperature conditions (5°C, 25°C, 40°C), and assayed using the high-performance liquid chromatographic assay at pre-determined intervals over an extended period of time as follows: 0, 7, 14, 30, 45, 60, 91, 120, and 182 days at each designated temperature. Physical data such as pH, viscosity, appearance, and average particle size were also monitored. The study showed that drug concentration did not go below 90% of the label claim (initial drug concentration) at room temperature and in the refrigerator. The pH values also did not change significantly. There was some variability in viscosity and average particle size. This study demonstrates that trimethoprim and sulfadiazine are physically and chemically stable in combination in SuspendIt for 182 days at room temperature and in the refrigerator, thus providing a viable, compounded alternative for both drugs in a liquid dosage form, with an extended beyond-use-date to meet patient needs.
[Mh] Termos MeSH primário: Sulfadiazina/química
Trimetoprima/química
[Mh] Termos MeSH secundário: Administração Oral
Cromatografia Líquida de Alta Pressão
Combinação de Medicamentos
Estabilidade de Medicamentos
Concentração de Íons de Hidrogênio
Sulfadiazina/administração & dosagem
Sulfadiazina/análise
Suspensões
Trimetoprima/administração & dosagem
Trimetoprima/análise
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Suspensions); 0N7609K889 (Sulfadiazine); AN164J8Y0X (Trimethoprim)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


  2 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Mineo, José Roberto
Texto completo
[PMID]:28803905
[Au] Autor:Ribeiro M; Franco PS; Lopes-Maria JB; Angeloni MB; Barbosa BF; Gomes AO; Castro AS; Silva RJD; Oliveira FC; Milian ICB; Martins-Filho OA; Ietta F; Mineo JR; Ferro EAV
[Ad] Endereço:Laboratory of Immunophysiology of Reproduction, Department of Histology and Embryology, Federal University of Uberlândia, Av. Pará, 1720, Uberlândia, CEP 38400 902, Brazil.
[Ti] Título:Azithromycin treatment is able to control the infection by two genotypes of Toxoplasma gondii in human trophoblast BeWo cells.
[So] Source:Exp Parasitol;181:111-118, 2017 Oct.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Trophoblast infection by Toxoplasma gondii plays a pivotal role in the vertical transmission of toxoplasmosis. Here, we investigate whether the antibiotic therapy with azithromycin, spiramycin and sulfadiazine/pyrimethamine are effective to control trophoblast infection by two Brazilian T. gondii genotypes, TgChBrUD1 or TgChBrUD2. Two antibiotic protocols were evaluated, as follow: i) pre-treatment of T. gondii-tachyzoites with selected antibiotics prior trophoblast infection and ii) post-treatment of infected trophoblasts. The infection index/replication and the impact of the antibiotic therapy on the cytokine milieu were characterized. It was observed that TgChBrUD2 infection induced lower infection index/replication as compared to TgChBrUD1. Regardless the therapeutic protocol, azithromycin was more effective to control the trophoblast infection with both genotypes when compared to conventional antibiotics. Azithromycin induced higher IL-12 production in TgChBrUD1-infected cells that may synergize the anti-parasitic effect. In contrast, the effectiveness of azithromycin to control the TgChBrUD2-infection was not associated with the IL-12 production. BeWo-trophoblasts display distinct susceptibility to T. gondii genotypes and the azithromycin treatment showed to be more effective than conventional antibiotics to control the T. gondii infection/replication regardless the parasite genotype.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Azitromicina/farmacologia
Toxoplasma/efeitos dos fármacos
Trofoblastos/parasitologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Citocinas/metabolismo
Combinação de Medicamentos
Genótipo
Seres Humanos
Interleucina-12/metabolismo
Pirimetamina/farmacologia
Espiramicina/farmacologia
Sulfadiazina/farmacologia
Toxoplasma/classificação
Toxoplasma/genética
Toxoplasma/imunologia
Trofoblastos/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Cytokines); 0 (Drug Combinations); 0N7609K889 (Sulfadiazine); 187348-17-0 (Interleukin-12); 8025-81-8 (Spiramycin); 83905-01-5 (Azithromycin); Z3614QOX8W (Pyrimethamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


  3 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28774497
[Au] Autor:Sanfelice RA; Machado LF; Bosqui LR; Miranda-Sapla MM; Tomiotto-Pellissier F; de Alcântara Dalevedo G; Ioris D; Reis GF; Panagio LA; Navarro IT; Bordignon J; Conchon-Costa I; Pavanelli WR; Almeida RS; Costa IN
[Ad] Endereço:Laboratório de Protozoologia Experimental - Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Paraná CEP 86051-990, Brazil.
[Ti] Título:Activity of rosuvastatin in tachyzoites of Toxoplasma gondii (RH strain) in HeLa cells.
[So] Source:Exp Parasitol;181:75-81, 2017 Oct.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Due to the toxicity of conventional medication in toxoplasmosis, some drugs are being studied for treating this infection, such as statins, especially rosuvastatin compound, which is efficient in inhibiting the initial isoprenoid biosynthesis processes in humans and the parasite. The goal of this study was to assess the activity of rosuvastatin in HeLa cells infected with the RH strain of T. gondii. In the experiment, HeLa cells (1 × 10 ) were infected with tachyzoites of T. gondii (5 × 10 ). After the experimental infection, we assessed the number of infected cells and the amount of intracellular tachyzoites. In addition, culture supernatants were collected to determine the amount of cytokines by cytometric bead array. We observed that there was no cytotoxicity in the concentrations tested in this cell line. The effect of rosuvastatin showed a significant reduction in both the number of infected cells and the proliferation index of the intracellular parasite, when compared with the conventional treatment combining sulfadiazine and pyrimethamine for toxoplasmosis. There were also reduced levels of cytokines IL-6 and IL-17. Therefore, it was concluded that rosuvastatin exhibited antiproliferative activity. The data presented are significant to promote further studies and the search for alternative treatment for toxoplasmosis.
[Mh] Termos MeSH primário: Células HeLa/parasitologia
Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia
Rosuvastatina Cálcica/farmacologia
Toxoplasma/efeitos dos fármacos
[Mh] Termos MeSH secundário: Análise de Variância
Antiprotozoários/farmacologia
Meios de Cultura
Células HeLa/efeitos dos fármacos
Seres Humanos
Inibidores de Hidroximetilglutaril-CoA Redutases/toxicidade
Interleucina-17/metabolismo
Interleucina-6/metabolismo
Pirimetamina/farmacologia
Rosuvastatina Cálcica/toxicidade
Sulfadiazina/farmacologia
Toxoplasma/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Culture Media); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Interleukin-17); 0 (Interleukin-6); 0N7609K889 (Sulfadiazine); 83MVU38M7Q (Rosuvastatin Calcium); Z3614QOX8W (Pyrimethamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


  4 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
[PMID]:28700086
[Au] Autor:Norman G; Christie J; Liu Z; Westby MJ; Jefferies JM; Hudson T; Edwards J; Mohapatra DP; Hassan IA; Dumville JC
[Ad] Endereço:Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Jean McFarlane Building, Oxford Road, Manchester, UK, M13 9PL.
[Ti] Título:Antiseptics for burns.
[So] Source:Cochrane Database Syst Rev;7:CD011821, 2017 07 12.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to prevent growth of micro-organisms. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. OBJECTIVES: To assess the effects and safety of antiseptics for the treatment of burns in any care setting. SEARCH METHODS: In September 2016 we searched the Cochrane Wounds Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, Ovid MEDLINE (In-Process & Other Non-Indexed Citations), Ovid Embase, and EBSCO CINAHL. We also searched three clinical trials registries and references of included studies and relevant systematic reviews. There were no restrictions based on language, date of publication or study setting. SELECTION CRITERIA: We included randomised controlled trials (RCTs) that enrolled people with any burn wound and assessed the use of a topical treatment with antiseptic properties. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, risk of bias assessment and data extraction. MAIN RESULTS: We included 56 RCTs with 5807 randomised participants. Almost all trials had poorly reported methodology, meaning that it is unclear whether they were at high risk of bias. In many cases the primary review outcomes, wound healing and infection, were not reported, or were reported incompletely.Most trials enrolled people with recent burns, described as second-degree and less than 40% of total body surface area; most participants were adults. Antiseptic agents assessed were: silver-based, honey, Aloe Vera, iodine-based, chlorhexidine or polyhexanide (biguanides), sodium hypochlorite, merbromin, ethacridine lactate, cerium nitrate and Arnebia euchroma. Most studies compared antiseptic with a topical antibiotic, primarily silver sulfadiazine (SSD); others compared antiseptic with a non-antibacterial treatment or another antiseptic. Most evidence was assessed as low or very low certainty, often because of imprecision resulting from few participants, low event rates, or both, often in single studies. Antiseptics versus topical antibioticsCompared with the topical antibiotic, SSD, there is low certainty evidence that, on average, there is no clear difference in the hazard of healing (chance of healing over time), between silver-based antiseptics and SSD (HR 1.25, 95% CI 0.94 to 1.67; I = 0%; 3 studies; 259 participants); silver-based antiseptics may, on average, increase the number of healing events over 21 or 28 days' follow-up (RR 1.17 95% CI 1.00 to 1.37; I = 45%; 5 studies; 408 participants) and may, on average, reduce mean time to healing (difference in means -3.33 days; 95% CI -4.96 to -1.70; I = 87%; 10 studies; 979 participants).There is moderate certainty evidence that, on average, burns treated with honey are probably more likely to heal over time compared with topical antibiotics (HR 2.45, 95% CI 1.71 to 3.52; I = 66%; 5 studies; 140 participants).There is low certainty evidence from single trials that sodium hypochlorite may, on average, slightly reduce mean time to healing compared with SSD (difference in means -2.10 days, 95% CI -3.87 to -0.33, 10 participants (20 burns)) as may merbromin compared with zinc sulfadiazine (difference in means -3.48 days, 95% CI -6.85 to -0.11, 50 relevant participants). Other comparisons with low or very low certainty evidence did not find clear differences between groups.Most comparisons did not report data on infection. Based on the available data we cannot be certain if antiseptic treatments increase or reduce the risk of infection compared with topical antibiotics (very low certainty evidence). Antiseptics versus alternative antisepticsThere may be some reduction in mean time to healing for wounds treated with povidone iodine compared with chlorhexidine (MD -2.21 days, 95% CI 0.34 to 4.08). Other evidence showed no clear differences and is of low or very low certainty. Antiseptics versus non-antibacterial comparatorsWe found high certainty evidence that treating burns with honey, on average, reduced mean times to healing in comparison with non-antibacterial treatments (difference in means -5.3 days, 95% CI -6.30 to -4.34; I = 71%; 4 studies; 1156 participants) but this comparison included some unconventional treatments such as amniotic membrane and potato peel. There is moderate certainty evidence that honey probably also increases the likelihood of wounds healing over time compared to unconventional anti-bacterial treatments (HR 2.86, 95% C 1.60 to 5.11; I = 50%; 2 studies; 154 participants).There is moderate certainty evidence that, on average, burns treated with nanocrystalline silver dressings probably have a slightly shorter mean time to healing than those treated with Vaseline gauze (difference in means -3.49 days, 95% CI -4.46 to -2.52; I = 0%; 2 studies, 204 participants), but low certainty evidence that there may be little or no difference in numbers of healing events at 14 days between burns treated with silver xenograft or paraffin gauze (RR 1.13, 95% CI 0.59 to 2.16 1 study; 32 participants). Other comparisons represented low or very low certainty evidence.It is uncertain whether infection rates in burns treated with either silver-based antiseptics or honey differ compared with non-antimicrobial treatments (very low certainty evidence). There is probably no difference in infection rates between an iodine-based treatment compared with moist exposed burn ointment (moderate certainty evidence). It is also uncertain whether infection rates differ for SSD plus cerium nitrate, compared with SSD alone (low certainty evidence).Mortality was low where reported. Most comparisons provided low certainty evidence that there may be little or no difference between many treatments. There may be fewer deaths in groups treated with cerium nitrate plus SSD compared with SSD alone (RR 0.22, 95% CI 0.05 to 0.99; I = 0%, 2 studies, 214 participants) (low certainty evidence). AUTHORS' CONCLUSIONS: It was often uncertain whether antiseptics were associated with any difference in healing, infections, or other outcomes. Where there is moderate or high certainty evidence, decision makers need to consider the applicability of the evidence from the comparison to their patients. Reporting was poor, to the extent that we are not confident that most trials are free from risk of bias.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Apiterapia/métodos
Infecções Bacterianas/terapia
Queimaduras/complicações
Queimaduras/terapia
Cicatrização
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Anti-Infecciosos Locais/efeitos adversos
Infecções Bacterianas/etiologia
Bandagens
Clorexidina/uso terapêutico
Desinfetantes/uso terapêutico
Seres Humanos
Merbromina/uso terapêutico
Preparações de Plantas/uso terapêutico
Povidona-Iodo/uso terapêutico
Ensaios Clínicos Controlados Aleatórios como Assunto
Sulfadiazina de Prata/uso terapêutico
Hipoclorito de Sódio/uso terapêutico
Sulfadiazina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Aloe vera gel); 0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Local); 0 (Disinfectants); 0 (Plant Preparations); 0N7609K889 (Sulfadiazine); 85H0HZU99M (Povidone-Iodine); DY38VHM5OD (Sodium Hypochlorite); M0T18YH28D (Merbromin); R4KO0DY52L (Chlorhexidine); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD011821.pub2


  5 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28427033
[Au] Autor:Xu Y; Yu W; Ma Q; Zhou H; Jiang C
[Ad] Endereço:Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.
[Ti] Título:Toxicity of sulfadiazine and copper and their interaction to wheat (Triticum aestivum L.) seedlings.
[So] Source:Ecotoxicol Environ Saf;142:250-256, 2017 Aug.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A pot experiment was carried out to investigate the single and combined effect of different concentrations of sulfadiazine (SDZ) (1 and 10mgkg ) and copper (Cu) (20 and 200mgkg ) stresses on growth, hydrogen peroxide (H O ), malondialdehyde (MDA), antioxidant enzyme activities of wheat seedlings and their accumulation. High SDZ or Cu level significantly inhibited the growth of wheat seedlings, but the emergence rate was only inhibited by high SDZ level. The presence of Cu reduced the accumulation of SDZ, whereas the effect of SDZ on the accumulation of Cu depended on their concentrations. Low Cu level significantly increased the chlorophyll content, while high Cu level or both SDZ concentrations resulted in a significant decrease in the chlorophyll content as compared to the control. Additionally, H O and MDA contents increased with the elevated SDZ or Cu level. The activities of superoxide dismutase, peroxidase and catalase were also stimulated by SDZ or Cu except for the aerial part treated by low Cu level and root treated by high SDZ level. The joint toxicity data showed that the toxicity of SDZ to wheat seedlings was generally alleviated by the presence of Cu, whereas the combined toxicity of SDZ and Cu was larger than equivalent Cu alone.
[Mh] Termos MeSH primário: Cobre/toxicidade
Plântulas/efeitos dos fármacos
Poluentes do Solo/toxicidade
Sulfadiazina/toxicidade
Triticum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Catalase/metabolismo
Clorofila/metabolismo
Interações Medicamentosas
Peróxido de Hidrogênio/metabolismo
Malondialdeído/metabolismo
Oxirredução
Peroxidase/metabolismo
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/metabolismo
Plântulas/crescimento & desenvolvimento
Plântulas/metabolismo
Superóxido Dismutase/metabolismo
Triticum/crescimento & desenvolvimento
Triticum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); 0N7609K889 (Sulfadiazine); 1406-65-1 (Chlorophyll); 4Y8F71G49Q (Malondialdehyde); 789U1901C5 (Copper); BBX060AN9V (Hydrogen Peroxide); EC 1.11.1.6 (Catalase); EC 1.11.1.7 (Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE


  6 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28397950
[Au] Autor:Aljahdali AH; Al-Buainain HM; Skarsgard ED
[Ad] Endereço:Department of Pediatric Surgery, King Fahad Hospital of the University, University of Dammam, Al Khobar, Kingdom of Saudi Arabia. E-mail. akramjahdali@gmail.com.
[Ti] Título:Staged closure of a giant omphalocele with amnion preservation, modified technique.
[So] Source:Saudi Med J;38(4):422-424, 2017 Apr.
[Is] ISSN:0379-5284
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:Closure of a giant omphalocele can be challenging. Preservation of the amnion in staged closure is not commonly practiced. Here, we describe 2 cases of giant omphalocele treated with a modified amnion preservation, staged closure technique. This paper demonstrates the feasibility and safety of this technique, and the versatility of amnion to adapt to an escharization strategy if closure is not achievable.
[Mh] Termos MeSH primário: Hérnia Umbilical/cirurgia
[Mh] Termos MeSH secundário: Âmnio/cirurgia
Fasciotomia
Evolução Fatal
Seres Humanos
Hipertensão Pulmonar/complicações
Hipertensão Pulmonar/diagnóstico por imagem
Lactente
Masculino
Sulfadiazina/administração & dosagem
Sulfassalazina/administração & dosagem
Telas Cirúrgicas
Ventiladores Mecânicos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0N7609K889 (Sulfadiazine); 3XC8GUZ6CB (Sulfasalazine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.15537/smj.2017.4.16240


  7 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28365339
[Au] Autor:Li Z; Chang Q; Li S; Gao M; She Z; Guo L; Zhao Y; Jin C; Zheng D; Xu Q
[Ad] Endereço:Key Lab of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao 266100, PR China; Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering, Ocean University of China, Qingdao 266100, PR China.
[Ti] Título:Impact of sulfadiazine on performance and microbial community of a sequencing batch biofilm reactor treating synthetic mariculture wastewater.
[So] Source:Bioresour Technol;235:122-130, 2017 Jul.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The impact of sulfadiazine on the performance, microbial activity and microbial community of a sequencing batch biofilm reactor (SBBR) were evaluated in treating mariculture wastewater due to the application of sulfadiazine as an antibiotic in mariculture. The COD and nitrogen removals kept stable at 0-6mg/L sulfadiazine and were inhibited at 10-35mg/L sulfadiazine. The microbial activities related to organic matter and nitrogen removals reduced with an increase in sulfadiazine concentration. The presence of sulfadiazine could affect the production and chemical composition of loosely bound extracellular polymeric substances (LB-EPS) and tightly bound EPS (TB-EPS) in the biofilm. High-throughput sequencing demonstrated that sulfadiazine could impact on the microbial richness and diversity of SBBR treating mariculture wastewater. The relative abundances of Nitrosomonas, Nitrospira, Paracoccus, Hyphomicrobium, Rhodanobacter, Thauera and Steroidobacter decreased with an increase in sulfadiazine concentration, indicating that the presence of sulfadiazine decreased the relative abundance of some nitrifying and denitrifying bacteria.
[Mh] Termos MeSH primário: Biofilmes
Águas Residuais/química
[Mh] Termos MeSH secundário: Reatores Biológicos/microbiologia
Nitrogênio/metabolismo
Sulfadiazina
Eliminação de Resíduos Líquidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Waste Water); 0N7609K889 (Sulfadiazine); N762921K75 (Nitrogen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


  8 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28258427
[Au] Autor:Biosic M; Mitrevski M; Babic S
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, 10000, Zagreb, Croatia. mperisa@fkit.hr.
[Ti] Título:Environmental behavior of sulfadiazine, sulfamethazine, and their metabolites.
[So] Source:Environ Sci Pollut Res Int;24(10):9802-9812, 2017 Apr.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sulfonamides are one of the most frequently used antibiotics worldwide. Therefore, processes that determine their fate in the environment are of great interest. In the present work, biodegradation as biotic process and hydrolysis and photolysis as abiotic processes were investigated. In biodegradation experiments, it was found out that sulfonamides (sulfadiazine and sulfamethazine) and their N -acetylated metabolites were not readily biodegradable. The results showed that decrease of concentrations were in the range from 4% for sulfadiazine to 22% for N -acetylsulfamethazine. Hydrolytic experiments examined at pH values normally found in the environment also showed their resistance. However, photolysis proved to be significant process for decreasing concentrations of sulfonamides and their metabolites in three various aqueous matrices (Milli-Q water, river water, and synthetic wastewater). In addition, influence of ubiquitous water constituents (Cl , NO , SO , PO , and humic acids) was also investigated, showing their different impact on photolysis of investigated pharmaceuticals. The results showed that photolysis followed first-order kinetics in all cases. The obtained results are very important for assesing the environmental fate of sulfonamides and their metabolites in the aquatic environment.
[Mh] Termos MeSH primário: Sulfadiazina
Sulfametazina
[Mh] Termos MeSH secundário: Antibacterianos
Fotólise
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Water Pollutants, Chemical); 0N7609K889 (Sulfadiazine); 48U51W007F (Sulfamethazine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8639-8


  9 / 2222 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28118394
[Au] Autor:Silva LA; Reis-Cunha JL; Bartholomeu DC; Vítor RW
[Ad] Endereço:Laboratório de Toxoplasmose, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.
[Ti] Título:Genetic Polymorphisms and Phenotypic Profiles of Sulfadiazine-Resistant and Sensitive Toxoplasma gondii Isolates Obtained from Newborns with Congenital Toxoplasmosis in Minas Gerais, Brazil.
[So] Source:PLoS One;12(1):e0170689, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous Toxoplasma gondii studies revealed that mutations in the dhps (dihydropteroate synthase) gene are associated with resistance to sulfonamides. Although Brazilian strains are genotypically different, very limited data are available regarding the susceptibility of strains obtained from human to sulfonamides. The aim of this study was to evaluate the efficacy of sulfadiazine (SDZ) against Brazilian isolates of T. gondii and verify whether isolates present polymorphisms in the dhps gene. We also investigated whether the virulence-phenotype and/or genotype were associated with the profile of susceptibility to SDZ. METHODS: Five T. gondii isolates obtained from newborns with congenital toxoplasmosis were used to verify susceptibility. Mice were infected with 104 tachyzoites and orally treated with different doses of SDZ. The mortality curve was evaluated by the Log-rank test. The presence of polymorphisms in the dhps gene was verified using sequencing. A descriptive analysis for 11 Brazilian isolates was used to assess the association between susceptibility, genotype, and virulence-phenotype. RESULTS: Statistical analysis showed that TgCTBr03, 07, 08, and 16 isolates were susceptible to SDZ, whereas TgCTBr11 isolate presented a profile of resistance to SDZ. Nineteen polymorphisms were identified in dhps exons. Seven polymorphisms corresponded to non-synonymous mutations, with four being new mutations, described for the first time in this study. No association was found between the profile of susceptibility and the virulence-phenotype or genotype of the parasite. CONCLUSIONS: There is a high variability in the susceptibilities of Brazilian T. gondii strains to SDZ, with evidence of drug resistance. Despite the large number of polymorphisms identified, the profile of susceptibility to SDZ was not associated with any of the dhps variants identified in this study. Other genetic factors, not yet determined, may be associated with the resistance to SDZ; thus, further studies are needed as a basis for a more adequate toxoplasmosis treatment.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Di-Hidropteroato Sintase/genética
Polimorfismo de Nucleotídeo Único
Proteínas de Protozoários/genética
Sulfadiazina/farmacologia
Toxoplasma/genética
Toxoplasmose Congênita/parasitologia
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/uso terapêutico
Sequência de Bases
Brasil/epidemiologia
Resistência a Medicamentos/genética
Feminino
Estudos de Associação Genética
Seres Humanos
Lactente
Recém-Nascido
Masculino
Camundongos
Mutação
Alinhamento de Sequência
Sulfadiazina/uso terapêutico
Toxoplasma/efeitos dos fármacos
Toxoplasma/patogenicidade
Toxoplasmose Animal/tratamento farmacológico
Toxoplasmose Congênita/tratamento farmacológico
Toxoplasmose Congênita/epidemiologia
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Protozoan Proteins); 0N7609K889 (Sulfadiazine); EC 2.5.1.15 (Dihydropteroate Synthase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170689


  10 / 2222 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28012669
[Au] Autor:Zhang M; Engelhardt I; Simunek J; Bradford SA; Kasel D; Berns AE; Vereecken H; Klumpp E
[Ad] Endereço:Agrosphere Institute (IBG-3), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany; Institute for Environmental Research (Biology V), RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. Electronic address: m.zhang@fz-juelich.de.
[Ti] Título:Co-transport of chlordecone and sulfadiazine in the presence of functionalized multi-walled carbon nanotubes in soils.
[So] Source:Environ Pollut;221:470-479, 2017 Feb.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Batch and saturated soil column experiments were conducted to investigate sorption and mobility of two C-labeled contaminants, the hydrophobic chlordecone (CLD) and the sulfadiazine (SDZ), in the absence or presence of functionalized multi-walled carbon nanotubes (MWCNTs). The transport behaviors of CLD, SDZ, and MWCNTs were studied at environmentally relevant concentrations (0.1-10 mg L ) and they were applied in the column studies at different times. The breakthrough curves and retention profiles were simulated using a numerical model that accounted for the advective-dispersive transport of all compounds, attachment/detachment of MWCNTs, equilibrium and kinetic sorption of contaminants, and co-transport of contaminants with MWCNTs. The experimental results indicated that the presence of mobile MWCNTs facilitated remobilization of previously deposited CLD and its co-transport into deeper soil layers, while retained MWCNTs enhanced SDZ deposition in the topsoil layers due to the increased adsorption capacity of the soil. The modeling results then demonstrated that the mobility of engineered nanoparticles (ENPs) in the environment and the high affinity and entrapment of contaminants to ENPs were the main reasons for ENP-facilitated contaminant transport. On the other hand, immobile MWCNTs had a less significant impact on the contaminant transport, even though they were still able to enhance the adsorption capacity of the soil.
[Mh] Termos MeSH primário: Clordecona/análise
Modelos Químicos
Nanotubos de Carbono/química
Poluentes do Solo/análise
Sulfadiazina/análise
[Mh] Termos MeSH secundário: Adsorção
Solo/química
Poluentes do Solo/química
Sulfadiazina/química
Simportadores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanotubes, Carbon); 0 (Soil); 0 (Soil Pollutants); 0 (Symporters); 0N7609K889 (Sulfadiazine); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161226
[St] Status:MEDLINE



página 1 de 223 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde