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[PMID]:28700086
[Au] Autor:Norman G; Christie J; Liu Z; Westby MJ; Jefferies JM; Hudson T; Edwards J; Mohapatra DP; Hassan IA; Dumville JC
[Ad] Endereço:Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Jean McFarlane Building, Oxford Road, Manchester, UK, M13 9PL.
[Ti] Título:Antiseptics for burns.
[So] Source:Cochrane Database Syst Rev;7:CD011821, 2017 07 12.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to prevent growth of micro-organisms. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. OBJECTIVES: To assess the effects and safety of antiseptics for the treatment of burns in any care setting. SEARCH METHODS: In September 2016 we searched the Cochrane Wounds Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, Ovid MEDLINE (In-Process & Other Non-Indexed Citations), Ovid Embase, and EBSCO CINAHL. We also searched three clinical trials registries and references of included studies and relevant systematic reviews. There were no restrictions based on language, date of publication or study setting. SELECTION CRITERIA: We included randomised controlled trials (RCTs) that enrolled people with any burn wound and assessed the use of a topical treatment with antiseptic properties. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, risk of bias assessment and data extraction. MAIN RESULTS: We included 56 RCTs with 5807 randomised participants. Almost all trials had poorly reported methodology, meaning that it is unclear whether they were at high risk of bias. In many cases the primary review outcomes, wound healing and infection, were not reported, or were reported incompletely.Most trials enrolled people with recent burns, described as second-degree and less than 40% of total body surface area; most participants were adults. Antiseptic agents assessed were: silver-based, honey, Aloe Vera, iodine-based, chlorhexidine or polyhexanide (biguanides), sodium hypochlorite, merbromin, ethacridine lactate, cerium nitrate and Arnebia euchroma. Most studies compared antiseptic with a topical antibiotic, primarily silver sulfadiazine (SSD); others compared antiseptic with a non-antibacterial treatment or another antiseptic. Most evidence was assessed as low or very low certainty, often because of imprecision resulting from few participants, low event rates, or both, often in single studies. Antiseptics versus topical antibioticsCompared with the topical antibiotic, SSD, there is low certainty evidence that, on average, there is no clear difference in the hazard of healing (chance of healing over time), between silver-based antiseptics and SSD (HR 1.25, 95% CI 0.94 to 1.67; I = 0%; 3 studies; 259 participants); silver-based antiseptics may, on average, increase the number of healing events over 21 or 28 days' follow-up (RR 1.17 95% CI 1.00 to 1.37; I = 45%; 5 studies; 408 participants) and may, on average, reduce mean time to healing (difference in means -3.33 days; 95% CI -4.96 to -1.70; I = 87%; 10 studies; 979 participants).There is moderate certainty evidence that, on average, burns treated with honey are probably more likely to heal over time compared with topical antibiotics (HR 2.45, 95% CI 1.71 to 3.52; I = 66%; 5 studies; 140 participants).There is low certainty evidence from single trials that sodium hypochlorite may, on average, slightly reduce mean time to healing compared with SSD (difference in means -2.10 days, 95% CI -3.87 to -0.33, 10 participants (20 burns)) as may merbromin compared with zinc sulfadiazine (difference in means -3.48 days, 95% CI -6.85 to -0.11, 50 relevant participants). Other comparisons with low or very low certainty evidence did not find clear differences between groups.Most comparisons did not report data on infection. Based on the available data we cannot be certain if antiseptic treatments increase or reduce the risk of infection compared with topical antibiotics (very low certainty evidence). Antiseptics versus alternative antisepticsThere may be some reduction in mean time to healing for wounds treated with povidone iodine compared with chlorhexidine (MD -2.21 days, 95% CI 0.34 to 4.08). Other evidence showed no clear differences and is of low or very low certainty. Antiseptics versus non-antibacterial comparatorsWe found high certainty evidence that treating burns with honey, on average, reduced mean times to healing in comparison with non-antibacterial treatments (difference in means -5.3 days, 95% CI -6.30 to -4.34; I = 71%; 4 studies; 1156 participants) but this comparison included some unconventional treatments such as amniotic membrane and potato peel. There is moderate certainty evidence that honey probably also increases the likelihood of wounds healing over time compared to unconventional anti-bacterial treatments (HR 2.86, 95% C 1.60 to 5.11; I = 50%; 2 studies; 154 participants).There is moderate certainty evidence that, on average, burns treated with nanocrystalline silver dressings probably have a slightly shorter mean time to healing than those treated with Vaseline gauze (difference in means -3.49 days, 95% CI -4.46 to -2.52; I = 0%; 2 studies, 204 participants), but low certainty evidence that there may be little or no difference in numbers of healing events at 14 days between burns treated with silver xenograft or paraffin gauze (RR 1.13, 95% CI 0.59 to 2.16 1 study; 32 participants). Other comparisons represented low or very low certainty evidence.It is uncertain whether infection rates in burns treated with either silver-based antiseptics or honey differ compared with non-antimicrobial treatments (very low certainty evidence). There is probably no difference in infection rates between an iodine-based treatment compared with moist exposed burn ointment (moderate certainty evidence). It is also uncertain whether infection rates differ for SSD plus cerium nitrate, compared with SSD alone (low certainty evidence).Mortality was low where reported. Most comparisons provided low certainty evidence that there may be little or no difference between many treatments. There may be fewer deaths in groups treated with cerium nitrate plus SSD compared with SSD alone (RR 0.22, 95% CI 0.05 to 0.99; I = 0%, 2 studies, 214 participants) (low certainty evidence). AUTHORS' CONCLUSIONS: It was often uncertain whether antiseptics were associated with any difference in healing, infections, or other outcomes. Where there is moderate or high certainty evidence, decision makers need to consider the applicability of the evidence from the comparison to their patients. Reporting was poor, to the extent that we are not confident that most trials are free from risk of bias.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Apiterapia/métodos
Infecções Bacterianas/terapia
Queimaduras/complicações
Queimaduras/terapia
Cicatrização
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Anti-Infecciosos Locais/efeitos adversos
Infecções Bacterianas/etiologia
Bandagens
Clorexidina/uso terapêutico
Desinfetantes/uso terapêutico
Seres Humanos
Merbromina/uso terapêutico
Preparações de Plantas/uso terapêutico
Povidona-Iodo/uso terapêutico
Ensaios Clínicos Controlados Aleatórios como Assunto
Sulfadiazina de Prata/uso terapêutico
Hipoclorito de Sódio/uso terapêutico
Sulfadiazina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Aloe vera gel); 0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Local); 0 (Disinfectants); 0 (Plant Preparations); 0N7609K889 (Sulfadiazine); 85H0HZU99M (Povidone-Iodine); DY38VHM5OD (Sodium Hypochlorite); M0T18YH28D (Merbromin); R4KO0DY52L (Chlorhexidine); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD011821.pub2


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[PMID]:28441045
[Au] Autor:Harmon CCG; Hawkins JF; Li J; Connell S; Miller M; Saenger M; Freeman LJ
[Ti] Título:Effects of topical application of silver sulfadiazine cream, triple antimicrobial ointment, or hyperosmolar nanoemulsion on wound healing, bacterial load, and exuberant granulation tissue formation in bandaged full-thickness equine skin wounds.
[So] Source:Am J Vet Res;78(5):638-646, 2017 May.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To determine the effects of 3 topically applied treatments (1% silver sulfadiazine cream [SSC], triple antimicrobial ointment [TAO], and hyperosmolar nanoemulsion [HNE]) on microbial counts, exuberant granulation tissue (EGT) development, and reepithelialization of contaminated wounds at the distal aspect of the limbs of horses. ANIMALS 8 healthy adult horses. PROCEDURES A 2.5 × 2.5-cm, full-thickness, cutaneous wound was created at the dorsal aspect of each metacarpus and metatarsus (1 wound/limb/horse), covered with nonadhesive dressing, and bandaged. Wounds were inoculated with bacteria and fungi the next day. Each wound on a given horse was randomly assigned to 1 of 4 treatment groups (SSC, TAO, HNE, or no topical treatment [control]). Bandage changes, culture of wound samples, treatments, photography for wound measurements, and biopsy were performed at predetermined time points. Time (days) until wound closure, number of EGT excisions, microbial counts, and scores for selected histologic characteristics were compared among groups. RESULTS Median time to wound closure for all groups was 42 days. Time to wound closure and histologic characteristics of wound healing did not differ among groups. Least squares mean microbial counts were significantly higher for HNE-treated wounds on days 9 and 21, compared with SSC-treated and TAO-treated wounds, but not controls. Proportions of SSC-treated (7/8) or HNE-treated (5/8) wounds needing EGT excision were significantly greater than that of TAO-treated (1/8) wounds. The proportion of SSC-treated wounds with EGT excision was greater than that of controls (3/8). CONCLUSIONS AND CLINICAL RELEVANCE None of the treatments resulted in more rapid wound closure, compared with that for untreated control wounds under the study conditions. When treatment is warranted, TAO may help to limit EGT formation.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Tecido de Granulação/efeitos dos fármacos
Cavalos/lesões
Sulfadiazina de Prata/uso terapêutico
Pele/lesões
Cicatrização/efeitos dos fármacos
Ferimentos Penetrantes/veterinária
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Anti-Infecciosos Locais/administração & dosagem
Carga Bacteriana/efeitos dos fármacos
Bandagens/veterinária
Extremidades
Feminino
Masculino
Nanocompostos
Sulfadiazina de Prata/administração & dosagem
Pele/microbiologia
Ferimentos Penetrantes/tratamento farmacológico
Ferimentos Penetrantes/microbiologia
Ferimentos Penetrantes/patologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.5.638


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[PMID]:28415495
[Au] Autor:Srivastava R; Sun Y
[Ad] Endereço:Department of Chemistry, University of Massachusetts, Lowell, MA 01854, USA.
[Ti] Título:Silver sulfadiazine immobilized glass as antimicrobial fillers for dental restorative materials.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:524-534, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bacterial colonization and biofilm formation on dental resin composites cause secondary caries that shortens the service life of dental restorative materials. In this study, commercial barium borosilicate based glass powders, fillers widely used in dental composites, were covalently immobilized with silver sulfadiazine to provide antimicrobial effects. The chemical reactions were followed by FT-IR study, elemental analysis, and energy dispersive spectroscopy (EDS), and the reaction pathway was confirmed by model compound studies. The resulting glass powders demonstrated potent antimicrobial effects against Streptococcus mutans (S. mutans). BisGMA (2,2-bis[4-(2-hydroxy-3-methacrylyloxypropoxy)phenyl] propane)-based dental resins containing 2% to 10% of the new silver sulfadiazine glass powders exhibited powerful and durable antimicrobial efficacy against S. mutans. The mechanical properties of the antimicrobial resins were not negatively affected by the silver sulfadiazine glass powders, making them attractive candidates as antimicrobial fillers for dental composites and other related biomedical applications.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Anti-Infecciosos/química
Resinas Compostas/química
Vidro/química
Poliuretanos/química
Sulfadiazina de Prata/química
Streptococcus mutans/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Anti-Infective Agents); 0 (Composite Dental Resin); 0 (Composite Resins); 0 (Polyurethanes); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28365493
[Au] Autor:Marchiori MCL; Rigon C; Camponogara C; Oliveira SM; Cruz L
[Ad] Endereço:Laboratório de Tecnologia Farmacêutica, Programa de Pós-graduação em Ciências: Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 1000, Prédio 26 - Camobi, Santa Maria - RS, 97105-900 Santa Maria, Brazil.
[Ti] Título:Hydrogel containing silibinin-loaded pomegranate oil based nanocapsules exhibits anti-inflammatory effects on skin damage UVB radiation-induced in mice.
[So] Source:J Photochem Photobiol B;170:25-32, 2017 May.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present study shows the development of a topical formulation (hydrogel) containing silibinin-loaded pomegranate oil based nanocapsules suspension and its evaluation as an alternative for the treatment of cutaneous UVB radiation-induced damages. For this, an animal model of skin injury induced by UVB radiation was employed. Gellan gum was used as gel forming agent by its direct addition to nanocapsules suspension. The hydrogels showed adequate pH values (5.6-5.9) and a silibinin content close to the theoretical value (1mg/g). Through vertical Franz diffusion cells it was demonstrated that nanocapsules decreased the silibinin retention in the semisolid formulation. All formulations were effective in reducing mice ear edema and leukocyte infiltration induced by UVB radiation 24h after the treatments. After 48h, only the hydrogels containing nanocapsules or silibinin associated with pomegranate oil demonstrated anti-edematogenic effect, as well as the positive control (hydrogel containing silver sulfadiazine 1%). After 72h, the hydrogel containing unloaded pomegranate oil based nanocapsules still presented a small activity. In conclusion, the results of this investigation demonstrated the feasibility to prepare a semisolid formulation presenting performance comparable to the traditional therapeutic option for skin burns (silver sulfadiazine) and with prolonged in vivo anti-inflammatory activity compared to the non-nanoencapsulated compounds.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Hidrogel de Polietilenoglicol-Dimetacrilato/química
Nanocápsulas/química
Óleos Vegetais/química
Silimarina/química
Pele/efeitos da radiação
Raios Ultravioleta
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Edema/tratamento farmacológico
Edema/metabolismo
Edema/patologia
Concentração de Íons de Hidrogênio
Masculino
Camundongos
Peroxidase/metabolismo
Punicaceae/química
Punicaceae/metabolismo
Sulfadiazina de Prata/uso terapêutico
Silimarina/uso terapêutico
Pele/metabolismo
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Nanocapsules); 0 (Plant Oils); 0 (Silymarin); 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate); 4RKY41TBTF (silybin); EC 1.11.1.7 (Peroxidase); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


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[PMID]:28329477
[Au] Autor:Tartar DM; Sharon VR
[Ti] Título:Second degree burn to mustard powder.
[So] Source:Dermatol Online J;23(1), 2017 Jan 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mustard seeds and powder are commonly used inhomeopathic and traditional medicines, in whichthey are believed to have both anti-microbial andanti-inflammatory properties. They are thereforeutilized in the treatment of conditions ranging fromarthritis to respiratory congestion. Herein, we presenta patient with a second degree burn who usedmustard powder in the form of a mustard plasterto treat chest congestion. She experienced seconddegree burn wounds to the lower neck and chest, andrecovery with complete re-epithelialization followingtopical silver sulfadiazine, liberal emollient therapy,and triamcinolone ointment. This case highlightsthe potential danger of inappropriate use of topicalhomeopathic remedies such as mustard powder anddetails a successful treatment regimen.
[Mh] Termos MeSH primário: Queimaduras Químicas/diagnóstico
Mostardeira
Sementes
[Mh] Termos MeSH secundário: Administração Cutânea
Anti-Infecciosos Locais/uso terapêutico
Queimaduras Químicas/etiologia
Emolientes/uso terapêutico
Feminino
Glucocorticoides/uso terapêutico
Seres Humanos
Meia-Idade
Pescoço
Sulfadiazina de Prata/uso terapêutico
Tórax
Triancinolona/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Emollients); 0 (Glucocorticoids); 1ZK20VI6TY (Triamcinolone); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28278234
[Au] Autor:Souza HR; de Azevedo LR; Possebon L; Costa SS; Iyomasa-Pilon MM; Oliani SM; Girol AP
[Ad] Endereço:Integrated College Padre Albino Foundation (FIPA), Catanduva, São Paulo, Brazil.
[Ti] Título:Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment.
[So] Source:PLoS One;12(3):e0173417, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mast cells (MCs) participate in all stages of skin healing and one of their mediators is the Annexin A1 protein (AnxA1), linked to inflammation, proliferation, migration and apoptosis processes, but not studied in thermal burns yet. Therefore, our objectives were to evaluate the behavior of MCs and AnxA1 in a second degree burn model, treated or not with silver sulfadiazine 1% (SDP 1%) and associated to macrophages quantification and cytokines dosages. MCs counts showed few cells in the early stages of repair but increased MCs in the final phases in the untreated group. The normal skin presented numerous tryptase-positive MCs that were reduced after burning in all analyzed periods. Differently, few chymase-positive MCs were observed in the early stages of healing, however, increased chymase-positive MCs were found at the final phase in the untreated group. MCs also showed high immunoreactivity for AnxA1 on day 3 in both groups. In the tissue there was a strong protein expression in the early stages of healing, but in the final phases only in the SDP treated animals. TNF-α, IL-1ß, IL-6, IL-10 and MCP-1 levels and macrophages quantification were increased in inflammation and reepithelialization phases. Reduced IL-1ß, IL-6 and IL-10 levels and numerous macrophages occurred in the treated animals during tissue repair. Our results indicate modulation in the profile of MCs and AnxA1expression during healing by the treatment with SDP 1%, pointing them as targets for therapeutic interventions on skin burns.
[Mh] Termos MeSH primário: Anexina A1/metabolismo
Queimaduras/tratamento farmacológico
Regulação da Expressão Gênica/efeitos dos fármacos
Mastócitos/citologia
Mastócitos/efeitos dos fármacos
Sulfadiazina de Prata/farmacologia
[Mh] Termos MeSH secundário: Animais
Queimaduras/imunologia
Queimaduras/metabolismo
Queimaduras/fisiopatologia
Contagem de Células
Proliferação Celular/efeitos dos fármacos
Citocinas/metabolismo
Citoplasma/efeitos dos fármacos
Citoplasma/metabolismo
Derme/efeitos dos fármacos
Derme/patologia
Modelos Animais de Doenças
Epiderme/efeitos dos fármacos
Epiderme/patologia
Histamina/metabolismo
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Ratos
Ratos Wistar
Sulfadiazina de Prata/uso terapêutico
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Annexin A1); 0 (Cytokines); 820484N8I3 (Histamine); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173417


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[PMID]:28267128
[Au] Autor:Britt SE; Coles KM; Polson SS
[Ad] Endereço:Sylvia E. Britt, PhD, RN, School of Nursing, University of Alabama at Birmingham, Alabama. Karen M. Coles, DNP, RN, School of Nursing, University of Alabama at Birmingham, Alabama. Shannon S. Polson, MSN, RN, CWCN, CFCN, CNL, School of Nursing, University of Alabama at Birmingham, Alabama.
[Ti] Título:Medical Adhesive-Related Skin Injury Following Emergent Appendectomy: A Case Study of MARSI and Missed Opportunities in Nursing Care.
[So] Source:J Wound Ostomy Continence Nurs;44(2):188-192, 2017 Mar/Apr.
[Is] ISSN:1528-3976
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The potential for skin damage from adhesive products is documented in the literature. Nevertheless, health care providers continue to lack understanding of the impact and seriousness of skin injury associated with use of tapes or other adhesive devices when applied to a patient with a history or hypersensitivity or allergy to adhesives. CASE: A 67-year-old woman with a history of tape allergy underwent emergency appendectomy. Initial removal of an adhesive bandage placed over the surgical incision revealed medical adhesive-related skin injury (MARSI). The largest of the 3 wounds was a Class III skin tear based on the Payne-Martin Classification System. It measured (L) 4.4 cm × (W) 1.8 cm × (D) 0.3 cm and required 3 months to heal. CONCLUSIONS: Experiences with this case revealed the need for evidence-based practice innovations to prevent physical, emotional, and economic cost resulting from MARSI. We recommend early identification and careful documentation of susceptibility to MARSI prior to surgery and implementation of consensus-based recommendations for prevention of MARSI as advocated by the MARSI consensus group when preparing patients for surgery and treating wounds.
[Mh] Termos MeSH primário: Adesivos/efeitos adversos
Apendicectomia/efeitos adversos
Complicações Pós-Operatórias/etiologia
Pele/lesões
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Bandagens/efeitos adversos
Contraindicações
Feminino
Seres Humanos
Sulfadiazina de Prata/farmacologia
Sulfadiazina de Prata/uso terapêutico
beta-Glucanas/farmacologia
beta-Glucanas/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesives); 0 (Anti-Bacterial Agents); 0 (beta-Glucans); 55965-23-6 (beta-glucan, (1-3)(1-4)-); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1097/WON.0000000000000309


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[PMID]:28248871
[Au] Autor:Saeidinia A; Keihanian F; Lashkari AP; Lahiji HG; Mobayyen M; Heidarzade A; Golchai J
[Ad] Endereço:aMedicinal Plants Research Center of Student Basij, Guilan University of Medical Sciences, Rasht bCardiology Department & Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad cPharmacognosy Department and Research and Development Center of Plants and Medicinal Chemistry dFellowship of Burn Surgery, Velayat Hospital eSocial Medicine Department fDermatology Department, Guilan University of Medical Sciences, Rasht, Iran.
[Ti] Título:Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm.
[So] Source:Medicine (Baltimore);96(9):e6168, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Burns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. On the basis of previous studies, we compared the efficacy of Centiderm versus silver sulfadiazine (SSD) in partial thickness burning patients. METHODS: Study population comprised burn victims referred to Velayat Burning Hospital at Rasht, Iran. The intervention group received Centiderm and control group SSD cream. Burn wounds were treated once daily at home. All of the wounds were evaluated till complete healing occurred and at the admission, days 3, 7, 14 objective signs; visual acuity score (VAS) and subjective signs were recorded. Re-epithelialization time and complete healing days were recorded. We used random fixed block for randomization. The randomization sequence was created using the computer. Patients and burning specialist physician were blinded. RESULTS: Seventy-five patients randomized into 2 groups; (40 patients: Centiderm group; 35 patients: SSD group). The mean age of them was 30.67 ±â€Š9.91 years and 19 of them were male (31.7%). Thirty patients in Centiderm and 30 patients in SSD group were analyzed. All of objective and subjective signs and mean of re-epithelialization and complete healing were significantly better in Centiderm group rather than SSD group (P < 0.05). There was no infection in Centiderm group. CONCLUSIONS: We showed that use of Centiderm ointment not only improved the objective and subjective signs in less than 3 days, but also the re-epithelialization and complete healing rather than SSD without any infection in the subjects.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Queimaduras/tratamento farmacológico
Reepitelização/efeitos dos fármacos
Sulfadiazina de Prata/uso terapêutico
Triterpenos/uso terapêutico
[Mh] Termos MeSH secundário: Administração Cutânea
Adulto
Anti-Infecciosos Locais/farmacologia
Centella
Feminino
Seres Humanos
Masculino
Fitoterapia
Sulfadiazina de Prata/farmacologia
Triterpenos/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Centella asiatica extract); 0 (Triterpenes); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006168


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[PMID]:28225874
[Au] Autor:Gomes MT; Campos GR; Piccolo N; França CM; Guedes GH; Lopes F; Belotto RA; Pavani C; Lima RD; Silva DF
[Ad] Endereço:Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, São Paulo, SP, Brazil.
[Ti] Título:Experimental burns: Comparison between silver sulfadiazine and photobiomodulation.
[So] Source:Rev Assoc Med Bras (1992);63(1):29-34, 2017 Jan 01.
[Is] ISSN:1806-9282
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyze morphological characteristics and organization of the collagen fibers of third degree burns from scalding compared to laser therapy and silver sulfadiazine, the latter considered as the gold standard. METHOD: Were selected 12 animals (Rattus norvegicus) also divided into three groups (control group [CG] - untreated burns; sulfadiazine group [SG] - burns were treated with silver sulfadiazine at 1%; laser group [LG] - burns were treated with photobiomodulation). The scald burns were carried out by using PVC mold, and the material collected on the 14th day after burn was prepared for morphological and optical retardation analysis for evaluation of inflammatory infiltrates and collagen organization, respectively. RESULTS: On the 14th day, the laser and sulfadiazine groups had mild inflammatory response, while the control group showed an intense inflammatory process, with statistical significance between laser and control groups, but not between sulfadiazine and control groups. Laser and sulfadiazine groups no longer had granulation tissue, opposite to what was seen in the control group. The presence of hair follicles and ulcer did not significantly differ between groups. The optical retardation of collagen fibers was higher in sulfadiazine group, followed by laser and control groups. As for systemic effect, we were able to identify it by simply analyzing the presence or absence of granulation tissue. CONCLUSION: Morphologically, the laser or silver sulfadiazine treatments were similar and both provided better organization of collagen fibers in relation to the untreated group. However, the sulfadiazine group modulated the deposition of collagen fibers more efficiently than the laser group.
[Mh] Termos MeSH primário: Queimaduras/tratamento farmacológico
Queimaduras/radioterapia
Terapia com Luz de Baixa Intensidade/métodos
Sulfadiazina de Prata/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Queimaduras/patologia
Colágeno/efeitos dos fármacos
Colágeno/efeitos da radiação
Modelos Animais de Doenças
Feminino
Ratos
Fatores de Tempo
Cicatrização/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
9007-34-5 (Collagen); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


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[PMID]:27697504
[Au] Autor:Kumar PM; Ghosh A
[Ad] Endereço:Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India.
[Ti] Título:Development and evaluation of silver sulfadiazine loaded microsponge based gel for partial thickness (second degree) burn wounds.
[So] Source:Eur J Pharm Sci;96:243-254, 2017 Jan 01.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Silver sulfadiazine has been frequently used as an antibacterial agent for topical treatment of partial thickness burn wounds. In this study, we present the preparation of silver sulfadiazine microsponges by w/o/w emulsion solvent evaporation method. Formulation variables were optimized by using 3 factorial design. The optimized microsponges were characterized by FTIR, DSC, PXRD, particle size analysis, SEM analysis and mercury intrusion porosimetry studies. Viscosity, texture analysis and ex vivo drug deposition study of optimized microsponge loaded gel were also evaluated. The safety of the optimized gel was assessed by MTT assay using epidermal keratinocyte (HaCaT) and mouse embryonic fibroblast (NIH-3T3) cell lines. In vitro antibacterial studies were carried out to compare the antibacterial inhibitory efficiency of the optimized gel against the commercial product. The efficacy of the optimized gel was evaluated by the partial thickness (second degree) burn wound model in mice. Optimized microsponge loaded gel enhanced the drug retaining capacity in the skin layers, by 3 fold higher to that of a commercial product. The antibacterial inhibitory efficiency of optimized gel was similar to the commercial product against the Staphylococcus aureus and Pseudomonas aeruginosa. Optimized gel showed reduced frequency of application, no skin irritation, low cytotoxicity on dermal cell lines and enhanced wound contraction.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/administração & dosagem
Queimaduras/tratamento farmacológico
Esponja de Gelatina Absorvível/administração & dosagem
Sulfadiazina de Prata/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos Locais/farmacocinética
Queimaduras/microbiologia
Queimaduras/patologia
Avaliação Pré-Clínica de Medicamentos/métodos
Escherichia coli/efeitos dos fármacos
Escherichia coli/fisiologia
Esponja de Gelatina Absorvível/farmacocinética
Géis
Camundongos
Testes de Sensibilidade Microbiana/métodos
Células NIH 3T3
Coelhos
Sulfadiazina de Prata/farmacocinética
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Gels); W46JY43EJR (Silver Sulfadiazine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE



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