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[PMID]:29217384
[Au] Autor:Markowicz-Piasecka M; Huttunen KM; Mikiciuk-Olasik E; Sikora J
[Ad] Endereço:Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszynskiego1, 90-151 Lodz, Poland. Electronic address: magdalena.markowicz@umed.lodz.pl.
[Ti] Título:Biocompatible sulfenamide and sulfonamide derivatives of metformin can exert beneficial effects on plasma haemostasis.
[So] Source:Chem Biol Interact;280:15-27, 2018 Jan 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:As the pharmacokinetic properties of metformin are unfavourable, several analogues and prodrugs have been synthesised to improve its bioavailability. The aim of this study was to assess the plasma stability of sulfenamide and sulfonamide derivatives of metformin and establish their effects on plasma haemostasis and integrity of red blood cells (RBCs). The overall haemostasis potential was evaluated spectrophotometrically by clot formation and lysis test (CL-test). PT (Prothrombin Time) and APTT (Activated Partial Tromboplastin Time) were used to evaluate the effects if the compounds on the extrinsic and intrinsic coagulation pathway. Haemolysis assay, microscopy and flow cytometry studies were conducted to determine the effect of the compounds on RBCs. Two sulfonamide and one sulfenamide derivatives of metformin were associated with a statistically significant decrease in the overall potential of clot formation and fibrinolysis (↓ CL ), suggesting that these compounds may exert beneficial effects regarding plasma haemostasis, which is frequently impaired in diabetic patients. p- and o-Nitrobenzene sulfonamides contributed to the beneficial change in kinetic parameters of clot formation and fibrinolysis. o-Nitrobenzene sulfonamide significantly increased thrombin generation time (↑ TGt) and was also found to prolong both APTT and PT. All compounds did not exert any effects on the integrity of RBCs over the concentration range 0.006-0.6 µmol/mL which constitutes the expected therapeutic concentration. In conclusion, sulfonamide derivatives of metformin present potentially beneficial properties in terms of plasma haemostasis which is frequently impaired in T2DM patients. Therefore, metformin sulfonamides may become a prototype for further design and synthesis of novel metformin analogues and prodrugs with improved pharmacokinetic properties.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Hemólise/efeitos dos fármacos
Metformina/análogos & derivados
Sulfamerazina/química
Sulfanilamidas/química
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/metabolismo
Materiais Biocompatíveis/farmacologia
Estabilidade de Medicamentos
Eritrócitos/citologia
Eritrócitos/efeitos dos fármacos
Eritrócitos/metabolismo
Fibrinólise/efeitos dos fármacos
Metformina/metabolismo
Metformina/farmacologia
Microscopia de Contraste de Fase
Tempo de Tromboplastina Parcial
Tempo de Protrombina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Sulfanilamides); 0 (sulfenamide); 21240MF57M (sulfanilamide); 9100L32L2N (Metformin); UR1SAB295F (Sulfamerazine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29229226
[Au] Autor:Murineddu G; Deligia F; Ragusa G; García-Toscano L; Gómez-Cañas M; Asproni B; Satta V; Cichero E; Pazos R; Fossa P; Loriga G; Fernández-Ruiz J; Pinna GA
[Ad] Endereço:Department of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy. Electronic address: muri@uniss.it.
[Ti] Título:Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB receptor ligand antagonists.
[So] Source:Bioorg Med Chem;26(1):295-307, 2018 01 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of sulfenamide and sulfonamide derivatives was synthesized and evaluated for the affinity at CB and CB receptors. The N-bornyl-S-(5,6-di-p-tolylpyridazin-3-yl)-sulfenamide, compound 11, displayed good affinity and high selectivity for CB receptors (K values of 44.6 nM for CB receptors and >40 µM for CB receptors, respectively). The N-isopinocampheyl-sulfenamide 12 and its sulfonamide analogue 22 showed similar selectivity for CB receptors with K values of 75.5 and 73.2 nM, respectively. These novel compounds behave as antagonists/inverse agonists at CB receptor in the [ S]-GTPγS binding assays, and none showed adequate predictive blood-brain barrier permeation, exhibiting low estimated LD . However, testing compound 12 in a supraspinal analgesic test (hot-plate) revealed that it was as effective as the classic CB receptor antagonist rimonabant, in reversing the analgesic effect of a cannabinoid agonist.
[Mh] Termos MeSH primário: Piridazinas/farmacologia
Receptor CB1 de Canabinoide/antagonistas & inibidores
Sulfamerazina/farmacologia
Sulfonamidas/farmacologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Seres Humanos
Ligantes
Simulação de Acoplamento Molecular
Estrutura Molecular
Piridazinas/química
Relação Estrutura-Atividade
Sulfamerazina/síntese química
Sulfamerazina/química
Sulfonamidas/síntese química
Sulfonamidas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ligands); 0 (Pyridazines); 0 (Receptor, Cannabinoid, CB1); 0 (Sulfonamides); 0 (sulfenamide); UR1SAB295F (Sulfamerazine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:28493705
[Au] Autor:Cai T; Bellamri M; Ming X; Koh WP; Yu MC; Turesky RJ
[Ti] Título:Quantification of Hemoglobin and White Blood Cell DNA Adducts of the Tobacco Carcinogens 2-Amino-9H-pyrido[2,3-b]indole and 4-Aminobiphenyl Formed in Humans by Nanoflow Liquid Chromatography/Ion Trap Multistage Mass Spectrometry.
[So] Source:Chem Res Toxicol;30(6):1333-1343, 2017 Jun 19.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aromatic amines covalently bound to hemoglobin (Hb) as sulfinamide adducts at the cysteine 93 residue of the Hb ß chain have served as biomarkers to assess exposure to this class of human carcinogens for the past 30 years. In this study, we report that 2-amino-9H-pyrido[2,3-b]indole (AαC), an abundant carcinogenic heterocyclic aromatic amine formed in tobacco smoke and charred cooked meats, also reacts with Hb to form a sulfinamide adduct. A novel nanoflow liquid chromatography/ion trap multistage mass spectrometry (nanoLC-IT/MS ) method was established to assess exposure to AαC and the tobacco-associated bladder carcinogen 4-aminobiphenyl (4-ABP) through their Hb sulfinamide adducts. Following mild acid hydrolysis of Hb in vitro, the liberated AαC and 4-ABP were derivatized with acetic anhydride to form the N-acetylated amines, which were measured by nanoLC-IT/MS . The limits of quantification (LOQ) for AαC- and 4-ABP-Hb sulfinamide adducts were ≤7.1 pg/g Hb. In a pilot study, the mean level of Hb sulfinamide adducts of AαC and 4-ABP were, respectively, 3.4-fold and 4.8-fold higher in smokers (>20 cigarettes/day) than nonsmokers. In contrast, the major DNA adducts of 4-ABP, N-(2'-deoxyguanosin-8-yl)-4-aminobiphenyl, and AαC, N-(2'-deoxyguanosin-8-yl)-2-amino-9H-pyrido[2,3-b]indole, were below the LOQ (3 adducts per 10 bases) in white blood cell (WBC) DNA of smokers and nonsmokers. These findings reaffirm that tobacco smoke is a major source of exposure to AαC. Hb sulfinamide adducts are suitable biomarkers to biomonitor 4-ABP and AαC; however, neither carcinogen binds to DNA in WBC, even in heavy smokers, at levels sufficient for biomonitoring.
[Mh] Termos MeSH primário: Compostos de Aminobifenil/química
Carbolinas/química
Carcinógenos/química
Adutos de DNA/análise
Hemoglobinas/química
Leucócitos/metabolismo
Tabaco/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Adutos de DNA/química
Hemoglobinas/análise
Seres Humanos
Espectrometria de Massas
Estrutura Molecular
Nanotecnologia
Sulfamerazina/análise
Sulfamerazina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminobiphenyl Compounds); 0 (Carbolines); 0 (Carcinogens); 0 (DNA Adducts); 0 (Hemoglobins); 0 (sulfenamide); 16054949HJ (4-biphenylamine); P0GZ1ICS6X (2-amino-9H-pyrido(2,3-b)indole); UR1SAB295F (Sulfamerazine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.7b00072


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[PMID]:28279875
[Au] Autor:Nong C; Niu Z; Li P; Wang C; Li W; Wen Y
[Ad] Endereço:Laboratory of Environmental Monitoring, School of Tropical and Laboratory Medicine, Hainan Medical University, Haikou 571199, China.
[Ti] Título:Dual-cloud point extraction coupled to high performance liquid chromatography for simultaneous determination of trace sulfonamide antimicrobials in urine and water samples.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1051:9-16, 2017 Apr 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dual-cloud point extraction (dCPE) was successfully developed for simultaneous extraction of trace sulfonamides (SAs) including sulfamerazine (SMZ), sulfadoxin (SDX), sulfathiazole (STZ) in urine and water samples. Several parameters affecting the extraction were optimized, such as sample pH, concentration of Triton X-114, extraction temperature and time, centrifugation rate and time, back-extraction solution pH, back-extraction temperature and time, back-extraction centrifugation rate and time. High performance liquid chromatography (HPLC) was applied for the SAs analysis. Under the optimum extraction and detection conditions, successful separation of the SAs was achieved within 9min, and excellent analytical performances were attained. Good linear relationships (R ≥0.9990) between peak area and concentration for SMZ and STZ were optimized from 0.02 to 10µg/mL, for SDX from 0.01 to 10µg/mL. Detection limits of 3.0-6.2ng/mL were achieved. Satisfactory recoveries ranging from 85 to 108% were determined with urine, lake and tap water spiked at 0.2, 0.5 and 1µg/mL, respectively, with relative standard deviations (RSDs, n=6) of 1.5-7.7%. This method was demonstrated to be convenient, rapid, cost-effective and environmentally benign, and could be used as an alternative tool to existing methods for analysing trace residues of SAs in urine and water samples.
[Mh] Termos MeSH primário: Anti-Infecciosos/análise
Anti-Infecciosos/urina
Cromatografia Líquida de Alta Pressão/métodos
Sulfonamidas/análise
Sulfonamidas/urina
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/urina
[Mh] Termos MeSH secundário: Fracionamento Químico/métodos
Água Potável/análise
Seres Humanos
Lagos/análise
Limite de Detecção
Polietilenoglicóis/química
Sulfadoxina/análise
Sulfadoxina/urina
Sulfamerazina/análise
Sulfamerazina/urina
Sulfatiazóis/análise
Sulfatiazóis/urina
Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Drinking Water); 0 (Sulfathiazoles); 0 (Sulfonamides); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 30IQX730WE (Polyethylene Glycols); 88463U4SM5 (Sulfadoxine); 9036-19-5 (Nonidet P-40); UR1SAB295F (Sulfamerazine); Y7FKS2XWQH (sulfathiazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


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[PMID]:27393211
[Au] Autor:Bayen S; Estrada ES; Juhel G; Kit LW; Kelly BC
[Ad] Endereço:Singapore-Delft Water Alliance, National University of Singapore, Singapore; Department of Food Science and Agricultural Chemistry, McGill University, Quebec, Canada. Electronic address: stephane.bayen@mcgill.ca.
[Ti] Título:Pharmaceutically active compounds and endocrine disrupting chemicals in water, sediments and mollusks in mangrove ecosystems from Singapore.
[So] Source:Mar Pollut Bull;109(2):716-22, 2016 Aug 30.
[Is] ISSN:1879-3363
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the occurrence of bisphenol A (BPA), atrazine and selected pharmaceutically active compounds (PhACs) in mangrove habitats in Singapore in 2012-2013, using multiple tools (sediment sampling, POCIS and filter feeder molluscs). Using POCIS, the same suite of contaminants (atrazine, BPA and eleven PhACs) was detected in mangrove waters in 28-days deployments in both 2012 and 2013. POCIS concentrations ranged from pg/L to µg/L. Caffeine, BPA, carbamazepine, E1, triclosan, sulfamerazine, sulfamethazine, and lincomycin were also detected in mangrove sediments from the low pg/g dw (e.g. carbamazepine) to ng/g dw (e.g. BPA). The detection of caffeine, carbamazepine, BPA, sulfamethoxazole or lincomycin in bivalve tissues also showed that these chemicals are bioavailable in the mangrove habitat. Since there are some indications that some pharmaceutically active substances may be biologically active in the low ppb range in marine species, further assessment should be completed based on ecotoxicological data specific to mangrove species.
[Mh] Termos MeSH primário: Disruptores Endócrinos/análise
Sedimentos Geológicos/análise
Moluscos/química
Preparações Farmacêuticas/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
Atrazina/análise
Compostos Benzidrílicos/análise
Carbamazepina/análise
Ecossistema
Monitoramento Ambiental
Lincomicina/análise
Fenóis/análise
Singapura
Sulfamerazina/análise
Sulfametazina/análise
Triclosan/análise
Zonas Úmidas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Endocrine Disruptors); 0 (Pharmaceutical Preparations); 0 (Phenols); 0 (Water Pollutants, Chemical); 33CM23913M (Carbamazepine); 48U51W007F (Sulfamethazine); 4NM5039Y5X (Triclosan); BOD072YW0F (Lincomycin); MLT3645I99 (bisphenol A); QJA9M5H4IM (Atrazine); UR1SAB295F (Sulfamerazine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160710
[St] Status:MEDLINE


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[PMID]:27198629
[Au] Autor:Pradhan E; Bhandari S; Gilbert RE; Stanford M
[Ad] Endereço:Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
[Ti] Título:Antibiotics versus no treatment for toxoplasma retinochoroiditis.
[So] Source:Cochrane Database Syst Rev;(5):CD002218, 2016 May 20.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acute toxoplasma retinochoroiditis causes transient symptoms of ocular discomfort and may lead to permanent visual loss. Antibiotic treatment aims primarily to reduce the risk of permanent visual loss, recurrent retinochoroiditis, and the severity and duration of acute symptoms. There is uncertainty about the effectiveness of antibiotic treatment. OBJECTIVES: To compare the effects of antibiotic treatment versus placebo or no treatment for toxoplasma retinochoroiditis. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision group Trials Register) (2016, Issue 1), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to February 2016), EMBASE (January 1980 to February 2016), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to February 2016), the ISRCTN registry (www.isrctn.com/editAdvancedSearch), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 22 February 2016. We searched the reference lists of identified articles and contacted pharmaceutical companies for unpublished trials. SELECTION CRITERIA: We included randomised controlled trials that compared any antibiotic treatment against placebo or no treatment. We excluded trials that included immunocompromised participants. We considered any antibiotic treatment known to be active against Toxoplasma gondii. Antibiotic treatment could be given in any dose orally, by intramuscular injection, by intravenous infusion, or by intravitreal injection. DATA COLLECTION AND ANALYSIS: The primary outcomes for this review were visual acuity at least three months after treatment and risk of recurrent retinochoroiditis. Secondary outcomes were improvement in symptoms and signs of intraocular inflammation, size of lesion, and adverse events. We used standard methodological procedures expected by Cochrane. MAIN RESULTS: Four trials that randomised a total of 268 participants met the inclusion criteria. In all four studies antibiotic was administered orally.One study conducted in Brazil in both adults and children compared trimethoprim-sulfamexacocol over 20 months to no treatment and was judged to be at high risk of performance, detection, and attrition bias. The other three studies compared antibiotic treatment to placebo. We judged these three studies to be at a mixture of low or unclear risk of bias due to poor reporting. One study conducted in the US in adults studied pyrimethamine-trisulfapyrimidine for eight weeks; one study conducted in the UK in children and adults evaluated pyrimethamine for four weeks; and one study conducted in Brazil in adults investigated trimethoprim-sulfamethoxazole for 12 months. In the last study, all participants had active retinochoroiditis and were treated with antibiotics for 45 days prior to randomisation to trimethoprim-sulfamethoxazole versus placebo.Only the study in Brazil of trimethoprim-sulfamethoxazole over 12 months, in participants with healed lesions, reported the effect of treatment on visual acuity. People treated with antibiotics may have a similar change in visual acuity compared with people treated with placebo at one year (mean difference -1.00 letters, 95% confidence interval (CI) -7.93 to 5.93 letters; 93 participants; low-quality evidence).Treatment with antibiotics probably reduces the risk of recurrent retinochoroiditis compared with placebo (risk ratio (RR) 0.26, 95% CI 0.11 to 0.63; 227 participants; 3 studies; I(2) = 0%; moderate-quality evidence); similar results were seen for acute and chronic retinochoroiditis.The UK study of pyrimethamine for four weeks reported an improvement in intraocular inflammation in treated compared with control participants (RR 1.76, 95% CI 0.98 to 3.19; 29 participants; low-quality evidence). The study in Brazil of trimethoprim-sulfamethoxazole for 12 months stated that the severity of inflammation was higher in the comparator group when compared to the antibiotic-treated group but did not provide further details. In the US study of pyrimethamine-trisulfapyrimidine for eight weeks intraocular inflammation had almost completely resolved by eight weeks in all participants, however in this study all participants received steroid treatment.Two studies (UK and US studies) reported an increased risk of adverse events in treated participants. These were a fall in haemoglobin, leucocyte, and platelet count, nausea, loss of appetite, rash, and arthralgia. AUTHORS' CONCLUSIONS: Treatment with antibiotics probably reduces the risk of recurrent toxoplasma retinochoroiditis, but there is currently no good evidence that this leads to better visual outcomes. However, absence of evidence of effect is not the same as evidence of no effect. Further trials of people with acute and chronic toxoplasma retinochoroiditis affecting any part of the retina are required to determine the effects of antibiotic treatment on visual outcomes.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Coriorretinite/tratamento farmacológico
Toxoplasmose Ocular/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Antibacterianos/administração & dosagem
Criança
Coriorretinite/parasitologia
Combinação de Medicamentos
Seres Humanos
Pirimetamina/uso terapêutico
Ensaios Clínicos Controlados Aleatórios como Assunto
Recidiva
Prevenção Secundária
Sulfadiazina/uso terapêutico
Sulfamerazina/uso terapêutico
Sulfametazina/uso terapêutico
Toxoplasmose Ocular/complicações
Combinação Trimetoprima e Sulfametoxazol/administração & dosagem
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
Acuidade Visual
Conduta Expectante
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drug Combinations); 0N7609K889 (Sulfadiazine); 48U51W007F (Sulfamethazine); 8017-57-0 (trisulfapyrimidine); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); UR1SAB295F (Sulfamerazine); Z3614QOX8W (Pyrimethamine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160521
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD002218.pub2


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[PMID]:26992818
[Au] Autor:Gniado K; Löbmann K; Rades T; Erxleben A
[Ad] Endereço:School of Chemistry, National University of Ireland, Galway, Ireland.
[Ti] Título:The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems.
[So] Source:Int J Pharm;504(1-2):20-6, 2016 May 17.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid, sulfamerazine/citric acid and sulfamerazine/sodium taurocholate (SMZ/DA, SMZ/CA and SMZ/NaTC; 1:1 molar ratio), is reported. While all three co-formers stabilize the amorphous state during storage, only co-amorphization with NaTC provides a dissolution advantage over crystalline SMZ and the reasons for this were analyzed. In the case of SMZ/DA extensive gelation of DA protects the amorphous phase from crystallization upon contact with buffer, but at the same time prevents the release of SMZ into solution. Disk dissolution studies showed an improved dissolution behavior of SMZ/CA compared to crystalline SMZ. However, enhanced dissolution properties were not seen in powder dissolution testing due to poor dispersibility. Co-amorphization of SMZ and NaTC resulted in a significant increase in dissolution rate, both in powder and disk dissolution studies.
[Mh] Termos MeSH primário: Ácido Cítrico/química
Ácido Desoxicólico/química
Excipientes/química
Sulfamerazina/química
Ácido Taurocólico/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Química Farmacêutica
Cristalização
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Excipients); 005990WHZZ (Deoxycholic Acid); 2968PHW8QP (Citric Acid); 5E090O0G3Z (Taurocholic Acid); UR1SAB295F (Sulfamerazine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160320
[St] Status:MEDLINE


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[PMID]:26878479
[Au] Autor:Batista APS; Teixeira ACSC; Cooper WJ; Cottrell BA
[Ad] Endereço:Chemical Engineering Department, School of Engineering, University of São Paulo, Av. Prof. Luciano Gualberto, 380, travessa 3, São Paulo, SP 05508-010, Brazil. Electronic address: nocomputador@gmail.com.
[Ti] Título:Correlating the chemical and spectroscopic characteristics of natural organic matter with the photodegradation of sulfamerazine.
[So] Source:Water Res;93:20-29, 2016 Apr 15.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of aquatic natural organic matter (NOM) in the removal of contaminants of emerging concern has been widely studied. Sulfamerazine (SMR), a sulfonamide antibiotic detected in aquatic environments, is implicated in environmental toxicity and may contribute to the resistance of bacteria to antibiotics. In aquatic systems sulfonamides may undergo direct photodegradation, and, indirect photodegradation through the generation of reactive species. Because some forms of NOM inhibit the photodegradation there is an increasing interest in correlating the spectroscopic parameters of NOM as potential indicators of its degradation in natural waters. Under the conditions used in this study, SMR hydrolysis was shown to be negligible; however, direct photolysis is a significant in most of the solutions studied. Photodegradation was investigated using standard solutions of NOM: Suwannee River natural organic matter (SRNOM), Suwannee River humic acid (SRHA), Suwannee River fulvic acid (SRFA), and Aldrich humic acid (AHA). The steady-state concentrations and formation rates of the reactive species and the SMR degradation rate constants (k1) were correlated with NOM spectroscopic parameters determined using UV-vis absorption, excitation-emission matrix (EEM) fluorescence spectroscopy, and proton nuclear magnetic resonance ((1)H NMR). SMR degradation rate constants (k1) were correlated with steady-state concentrations of NOM triplet-excited state ([(3)NOM(∗)]ss) and the corresponding formation rates ((3)NOM*) for SRNOM, SRHA, and AHA. The efficiency of SMR degradation was highest in AHA solution and was inhibited in solutions of SRFA. The steady-state concentrations of singlet oxygen ([(1)O2]ss) and the SMR degradation rate constants with singlet oxygen (k1O2) were linearly correlated with the total fluorescence and inversely correlated with the carbohydrate/protein content ((1)H NMR) for all forms of NOM. The total fluorescence and EEMs Peak A were confirmed as indicators of (1)O2 formation. Specific ultraviolet absorbance at 254 nm (SUVA254) and aromaticity showed potential correlations with the steady-state concentrations of hydroxyl radical ([HO]ss) and the corresponding formation rates (HO).
[Mh] Termos MeSH primário: Compostos Orgânicos/química
Espectrometria de Fluorescência/métodos
Espectrofotometria Ultravioleta/métodos
Sulfamerazina/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Benzopiranos/química
Substâncias Húmicas/análise
Radical Hidroxila/química
Cinética
Fotólise/efeitos da radiação
Espectroscopia de Prótons por Ressonância Magnética/métodos
Rios/química
Oxigênio Singlete/química
Soluções/química
Luz Solar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Benzopyrans); 0 (Humic Substances); 0 (Organic Chemicals); 0 (Solutions); 0 (Water Pollutants, Chemical); 17778-80-2 (Singlet Oxygen); 3352-57-6 (Hydroxyl Radical); UR1SAB295F (Sulfamerazine); XII14C5FXV (fulvic acid)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160216
[St] Status:MEDLINE


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[PMID]:26758493
[Au] Autor:Park CM; Biggs TD; Xian M
[Ad] Endereço:Department of Chemistry, Washington State University, Pullman, WA 99164, United States.
[Ti] Título:Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols.
[So] Source:J Antibiot (Tokyo);69(4):313-318, 2016 04.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:S-Nitrosothiols (RSNOs) have many biological implications but are rarely used in organic synthesis. In this work we report the development of proline-based phosphoramidite substrates that can effectively convert RSNOs to proline-based sulfenamides through a reductive ligation process. A unique property of this method is that the phosphine oxide moiety on the ligation products can be readily removed under acidic conditions. In conjugation with the facile preparation of RSNOs from the corresponding thiols (RSHs), this method provides a new way to prepare proline-based sulfenamides from simple thiol starting materials.
[Mh] Termos MeSH primário: Compostos Organofosforados/química
Prolina/química
S-Nitrosotióis/química
[Mh] Termos MeSH secundário: Óxido Nítrico/química
Oxirredução
Fosfinas/química
Sulfamerazina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Organophosphorus Compounds); 0 (Phosphines); 0 (S-Nitrosothiols); 0 (phosphoramidite); 0 (sulfenamide); 31C4KY9ESH (Nitric Oxide); 9DLQ4CIU6V (Proline); FW6947296I (phosphine); UR1SAB295F (Sulfamerazine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160114
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2015.144


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[PMID]:26757126
[Au] Autor:Jarova K; Vavrova M; Koleckarova A
[Ad] Endereço:Department of Ecology and Diseases of Game, Fish and Bees, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.
[Ti] Título:Residues of selected antibiotics in the South Moravian Rivers, Czech Republic.
[So] Source:Neuro Endocrinol Lett;36 Suppl 1:100-5, 2015.
[Is] ISSN:0172-780X
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to assess the contamination level of aquatic ecosystems of the Oslava and the Jihlava Rivers, and of the Nove Mlyny Water Reservoir, situated in the South Moravian Region (Czech Republic), by residues of selected veterinary pharmaceuticals. We isolated and determined 10 sulfonamide antibiotics in samples of surface water and bottom sediments using optimized analytical methods. DESIGN: A representative number of sampling sites in the entire basin of selected waters were chosen. Samples were collected particularly near the larger cities in order to assess their possible impact to the aquatic ecosystems. Extraction, pre-concentration and purification of samples were performed using optimized methods of solid phase extraction and pressurized solvent extraction. Final identification and quantification were carried out by high-performance liquid chromatography coupled with diode array detector. RESULTS: The concentration of sulfonamides in water samples were all under the limit of detection. Regarding sediment samples, sulfadimidine was found at most sampling sites; its highest values were recorded in the Jihlava River (up to 979.8 µg.kg(-1) dry matter). Other frequently detected sulfonamides were sulfamethoxazole and sulfamerazine. Most other sulfonamides were under the limit of detection or limit of quantification. CONCLUSIONS: Monitoring of antibiotic residues in the environment, especially in the aquatic ecosystem, is a current topic due to the growing worldwide use in both human and veterinary medicine. According to obtained results, we document the pollution of selected rivers and water reservoir by particular sulfonamides which basically reflects their application in veterinary medicine.
[Mh] Termos MeSH primário: Antibacterianos/análise
Rios/química
Sulfamerazina/análise
Sulfametazina/análise
Sulfametoxazol/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
República Tcheca
Resíduos de Drogas
Extração em Fase Sólida
Sulfonamidas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Sulfonamides); 0 (Water Pollutants, Chemical); 48U51W007F (Sulfamethazine); JE42381TNV (Sulfamethoxazole); UR1SAB295F (Sulfamerazine)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160305
[Lr] Data última revisão:
160305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160113
[St] Status:MEDLINE



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