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[PMID]:27424205
[Au] Autor:Shah S; Hao C
[Ad] Endereço:State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China.
[Ti] Título:Density functional theory study of direct and indirect photodegradation mechanisms of sulfameter.
[So] Source:Environ Sci Pollut Res Int;23(19):19921-30, 2016 Oct.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sulfonamide antibiotics (SAs) have been observed to undergo direct and indirect photodegradation in natural water environments. In this study, the density functional theory (DFT) method was employed for the study of direct and indirect photodegradation mechanisms of sulfameter (SME) with excited triplet states of dissolved organic matter ((3)DOM(*)) and metal ions. SME was adopted as a representative of SAs, and SO2 extrusion product was obtained with different energy paths in the triplet-sensitized photodegradation of the neutral (SME(0)) and the anionic (SME(-)) form of SME. The selected divalent metal ions (Ca(2+), Mg(2+), and Zn(2+)) promoted the triplet-sensitized photodegradation of SME(0) but showed an inhibitory effect in triplet-sensitized photodegradation of SME(-). The triplet-sensitized indirect photodegradation mechanism of SME was investigated with the three DOM analogues, i.e., 2-acetonaphthone (2-AN), fluorenone (FN), and thioxanthone (TN). Results indicated that the selected DOM analogues are highly responsible for the photodegradation via attacking on amine moiety of SME. According to the natural bond orbital (NBO) analysis, the triplet-sensitized photodegradation mechanism of SME(0) with 2-AN, FN, and TN was H-transfer, and the SME(-) was proton plus electron transfer with these DOM analogues.
[Mh] Termos MeSH primário: Fotólise
Sulfameter
Poluentes Químicos da Água
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Metais Pesados/química
Sulfameter/análise
Sulfameter/química
Sulfameter/efeitos da radiação
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/química
Poluentes Químicos da Água/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Water Pollutants, Chemical); 3L179F09D6 (Sulfameter)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160718
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6956-y


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[PMID]:27374578
[Au] Autor:Jansomboon W; Boontanon SK; Boontanon N; Polprasert C; Thi Da C
[Ad] Endereço:Department of Civil and Environmental Engineering, Faculty of Engineering, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand.
[Ti] Título:Monitoring and determination of sulfonamide antibiotics (sulfamethoxydiazine, sulfamethazine, sulfamethoxazole and sulfadiazine) in imported Pangasius catfish products in Thailand using liquid chromatography coupled with tandem mass spectrometry.
[So] Source:Food Chem;212:635-40, 2016 Dec 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This research aimed to monitor the concentrations of sulfamethoxydiazine (SMD), sulfamethazine (SMT), sulfamethoxazole (SMX) and sulfadiazine (SDZ) in imported Pangasius catfish products in Thailand. The residues of the four sulfonamides (SAs) were analyzed by extraction process and liquid chromatography coupled with tandem mass spectrometry. The highest concentrations found were 10.97ng/g for SMD, 6.23ng/g for SMT, 11.13ng/g for SDZ and 245.91ng/g for SMX, which was higher than the European Union (EU) standard (100ng/g). Moreover, all samples contaminated with SMX also contained SMT, indicating that more than one antibiotic was used for production in the country of origin. Because Thai standards for antibiotics in food have not been completely set, all contaminated discovered would not be considered to be an illegal food, in which antibiotic residues may affect human health in the long term. Therefore, antibiotic residues in Pangasius catfish products should be continually regulated and monitored.
[Mh] Termos MeSH primário: Antibacterianos/análise
Produtos Pesqueiros/análise
Contaminação de Alimentos/análise
Análise de Perigos e Pontos Críticos de Controle/métodos
Sulfonamidas/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Peixes-Gato
Cromatografia Líquida/métodos
Sulfadiazina/análise
Sulfameter/análise
Sulfametazina/análise
Sulfametoxazol/análise
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Sulfonamides); 0N7609K889 (Sulfadiazine); 3L179F09D6 (Sulfameter); 48U51W007F (Sulfamethazine); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160705
[St] Status:MEDLINE


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[PMID]:26524165
[Au] Autor:Tailor SM; Patel UH
[Ad] Endereço:Department of Physics, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India.
[Ti] Título:Hirshfeld surface analysis of sulfameter (polymorph III), sulfameter dioxane monosolvate and sulfameter tetrahydrofuran monosolvate, all at 296 K.
[So] Source:Acta Crystallogr C Struct Chem;71(Pt 11):944-53, 2015 Nov.
[Is] ISSN:2053-2296
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ability of the antibacterial agent sulfameter (SMT) to form solvates is investigated. The X-ray crystal structures of sulfameter solvates have been determined to be conformational polymorphs. Both 1,4-dioxane and tetrahydrofuran form solvates with sulfameter in a 1:1 molar ratio. 4-Amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide (polymorph III), C11H12N4O3S, (1), has two molecules of sulfameter in the asymmetric unit cell. 4-Amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide 1,4-dioxane monosolvate, C11H12N4O3S·C4H8O2, (2), and 4-amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide tetrahydrofuran monosolvate, C11H12N4O3S·C4H8O, (3), crystallize in the imide form. Hirshfeld surface analyses and fingerprint analyses were performed to study the nature of the interactions and their quantitative contributions towards the crystal packing. Finally, Hirshfeld surfaces, fingerprint plots and structural overlays were employed for a comparison of the two independent molecules in the asymmetric unit of (1), and also for a comparison of (2) and (3) in the monoclinic crystal system. A three-dimensional hydrogen-bonding network exists in all three structures, involving one of the sulfone O atoms and the aniline N atom. All three structures are stabilized by strong intermolecular N-H···N interactions. The tetrahydrofuran solvent molecule also takes part in forming significant intermolecular C-H···O interactions in the crystal structure of (3), contributing to the stability of the crystal packing.
[Mh] Termos MeSH primário: Antibacterianos/análise
Dioxanos/química
Furanos/química
Sulfameter/análise
Sulfonamidas/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Cristalografia por Raios X
Ligações de Hidrogênio
Modelos Moleculares
Conformação Molecular
Sulfameter/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (4-amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide tetrahydrofuran); 0 (Anti-Bacterial Agents); 0 (Dioxanes); 0 (Furans); 0 (Sulfonamides); 3L179F09D6 (Sulfameter); J8A3S10O7S (1,4-dioxane)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151103
[Lr] Data última revisão:
151103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151103
[St] Status:MEDLINE
[do] DOI:10.1107/S2053229615017520


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[PMID]:24725865
[Au] Autor:Zhang Q; Xiao X; Li G
[Ad] Endereço:School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China; School of Biology and Chemistry, Xingyi Normal University for Nationalities, Xingyi 562400, China.
[Ti] Título:Porous molecularly imprinted monolithic capillary column for on-line extraction coupled to high-performance liquid chromatography for trace analysis of antimicrobials in food samples.
[So] Source:Talanta;123:63-70, 2014 Jun.
[Is] ISSN:1873-3573
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A novel porous molecularly imprinted monolithic capillary column (MIMCC) based on ternary porogen was synthesized by in situ technique with sulfaquinoxaline as the template molecule. The characteristics of the MIMCC were investigated by scanning electron microscopy, infrared spectrum, thermogravimetric analysis and solvent resistance test. The saturated adsorption amount of sulfaquinoxaline on MIMCC was 2.7 times over that on the non-imprinted monolithic capillary column (NIMCC). The MIMCC also exhibited good enrichment ability to its analogs and the enrichment factors were 46-211 for five antimicrobials. High permeability and imprinting factors as well as good stability, reproducibility and long lifetime were obtained. An on-line method based on MIMCC solid-phase microextraction coupled with high-performance liquid chromatography was developed for the determination of trace antimicrobials in complex samples. The good linearity for sulfametoxydiazine, sulamethoxazole and sulfaquinoxaline was 0.05-10 µg/L, the limits of detection (LODs) were 10.0-14.0 ng/L. The linear range for mequindox and quinocetone were 0.10-10.0 µg/L, the LODs were 20.0-27.0 ng/L respectively. The recoveries were 71.0-108.2% with relative standard deviation of 1.6-8.5%, correspondingly. The results showed that MIMCC could effectively enrich antimicrobials from complex matrices. The on-line method based on MIMCC and HPLC was selective, sensitive and convenient for trace determination of antimicrobials in complex samples.
[Mh] Termos MeSH primário: Anti-Infecciosos/análise
Cromatografia Líquida de Alta Pressão/métodos
Análise de Alimentos/métodos
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Galinhas
Cromatografia Líquida de Alta Pressão/instrumentação
Ovos/análise
Carne/análise
Metacrilatos/química
Microscopia Eletrônica de Varredura
Impressão Molecular
Estrutura Molecular
Porosidade
Quinoxalinas/análise
Quinoxalinas/química
Quinoxalinas/isolamento & purificação
Reprodutibilidade dos Testes
Dióxido de Silício/química
Solventes/química
Espectrofotometria Infravermelho
Sulfameter/análise
Sulfameter/química
Sulfameter/isolamento & purificação
Sulfaquinoxalina/análise
Sulfaquinoxalina/química
Sulfaquinoxalina/isolamento & purificação
Suínos
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Mequindox); 0 (Methacrylates); 0 (Quinoxalines); 0 (Solvents); 0 (quinocetone); 3L179F09D6 (Sulfameter); 7631-86-9 (Silicon Dioxide); WNW8115TM9 (Sulfaquinoxaline)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:140414
[Lr] Data última revisão:
140414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140415
[St] Status:MEDLINE


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[PMID]:21795101
[Au] Autor:Wu Y; Yu S; Yu F; Yan N; Qu L; Zhang H
[Ad] Endereço:College of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou 450001, China. wuyongjun@zzu.edu.cn
[Ti] Título:Chemiluminescence enzyme immunoassay for the determination of sulfamethoxydiazine.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;81(1):544-7, 2011 Oct 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sulfamethoxydiazine (SMD), which is often used for animal disease treatment, is harmful to human health. No SMD residue should be detected in food in some countries, such as USA and Japan. Therefore, it is significant to develop a high-throughput, high-sensitivity and accurate method for the determination of the content of SMD in food. In this paper, chemiluminescence enzyme immunoassay (CLEIA) was developed for quantification of SMD. For this method, the limit of detection was 3.2 pg/ml, the linear range was from 10 to 2000 pg/ml, the within-day and inter-day precision were below 13% and below 18%, respectively, and the recovery was from 85% to 105%. Milk and egg were selected as samples to be examined with this method, and the result indicated that this CLEIA method was suitable for screening and quality control of food.
[Mh] Termos MeSH primário: Medições Luminescentes/métodos
Sulfameter/análise
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/análise
Calibragem
Ovos/análise
Análise de Alimentos/métodos
Contaminação de Alimentos/análise
Ensaios de Triagem em Larga Escala/métodos
Ensaios de Triagem em Larga Escala/normas
Seres Humanos
Técnicas Imunoenzimáticas/métodos
Técnicas Imunoenzimáticas/normas
Limite de Detecção
Medições Luminescentes/normas
Leite/química
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 3L179F09D6 (Sulfameter)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110729
[St] Status:MEDLINE
[do] DOI:10.1016/j.saa.2011.06.047


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[PMID]:21287695
[Au] Autor:Sun H; Chen P; Li L; Cheng P
[Ad] Endereço:College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, China. hanwen@hbu.edu.cn
[Ti] Título:A novel chemiluminescence quenching method for determination of sulfonamides in pharmaceutical and biological fluid based on luminol-Ag(III) complex reaction in alkaline solution.
[So] Source:Drug Test Anal;3(5):300-5, 2011 May.
[Is] ISSN:1942-7611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel chemiluminescence (CL) quenching method for the determination of sulfonamides is proposed. The CL reaction between Ag(III) complex [Ag(HIO6)2]5⁻ and luminol in alkaline solution was investigated. The quenching effect of sulfonamides on CL emission of [Ag(HIO6)2]5⁻-luminol system was found. Quenching degree of CL emission was proportional to sulfonamide concentration. The effects of the reaction conditions on CL emission and quenching were examined. Under optimal conditions, the detection limits (s/n = 3) were 7.2, 17 and 8.3 ng/mL for sulfadiazine, sulfameter, and sulfadimethoxine, respectively. The recoveries of the three drugs were in the range of 91.3-110% with RSDs of 1.9-2.7% for urine samples, and 106-112% with RSDs of 1.6-2.8% for serum samples. The proposed method was used for the determination of sulfadiazine at clinically relevant concentrations in real urine and serum samples with satisfactory results.
[Mh] Termos MeSH primário: Medições Luminescentes/métodos
Sulfadiazina/análise
Sulfadimetoxina/análise
Sulfameter/análise
[Mh] Termos MeSH secundário: Anti-Infecciosos/análise
Anti-Infecciosos/sangue
Anti-Infecciosos/urina
Seres Humanos
Luminol/química
Prata/química
Sulfadiazina/sangue
Sulfadiazina/urina
Sulfadimetoxina/sangue
Sulfadimetoxina/urina
Sulfameter/sangue
Sulfameter/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0N7609K889 (Sulfadiazine); 30CPC5LDEX (Sulfadimethoxine); 3L179F09D6 (Sulfameter); 3M4G523W1G (Silver); 5EXP385Q4F (Luminol)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:160511
[Lr] Data última revisão:
160511
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110203
[St] Status:MEDLINE
[do] DOI:10.1002/dta.249


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[PMID]:17975809
[Au] Autor:Khawam A; Flanagan DR
[Ad] Endereço:Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA. ammar-khawam@uiowa.edu
[Ti] Título:Desolvation kinetics of sulfameter solvates.
[So] Source:J Pharm Sci;97(6):2160-75, 2008 Jun.
[Is] ISSN:0022-3549
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Solvates are often encountered in pharmaceutical solids and knowledge of their physical stability is necessary for their effective formulation. This work investigates the solid-state stability of five structurally related solvates of sulfameter (5-methoxysulfadiazine) by studying the kinetics of their desolvation reaction with thermogravimetric analysis, both isothermally and nonisothermally. Desolvation kinetic analysis was done isothermally by conventional model-fitting and nonisothermally by the complementary method. Calculated kinetic parameters (model, A and E(a)) were compared and related to the crystal structure of these solvates. A relationship was established between desolvation activation energy from isothermal results and solvent size; the larger the solvent molecule, the higher its solvate's desolvation activation energy. The best fitting solid-state reaction model correlated to single crystal structural features of sulfameter-solvates where solvent molecules occupied cavities in the unit cell. Finally, it was found that kinetic parameters obtained isothermally and nonisothermally were at variance. Therefore, kinetic results obtained from one method may not be extended to results form the other.
[Mh] Termos MeSH primário: Anti-Infecciosos Urinários/química
Sulfameter/química
[Mh] Termos MeSH secundário: Química Farmacêutica
Cristalização
Estabilidade de Medicamentos
Cinética
Modelos Químicos
Solubilidade
Tecnologia Farmacêutica/métodos
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 3L179F09D6 (Sulfameter)
[Em] Mês de entrada:0808
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071103
[St] Status:MEDLINE


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[PMID]:16250451
[Au] Autor:Qin Y; Zhang M; Lin H
[Ad] Endereço:Guangzhou Entry & Exit Inspection and Quarantine Bureau, Guangzhou 510623, China. qinyanzz@hotmail.com
[Ti] Título:[Qualification and quantification of 10 sulfonamides in animal feedstuff by high performance liquid chromatography-electrospray tandem mass spectrometry].
[So] Source:Se Pu;23(4):397-400, 2005 Jul.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The presence of sulfonamide (SA) residues in foods is largely due to the raising of animals with sulfonamide antibiotics added or polluted feedstuff. Because of interference from the matrices, the commonly used immunoassay or chromatographic method is not suitable for the analysis of multi-SAs in feedstuff. A high performance liquid chromatographic-electrospray tandem mass spectrometric (HPLC/ESI-MS-MS) method has been established for the simultaneous determination of multi-SAs including sulfadiazine (SD), sulfapyridine (SPD), sulfamerazine (SM1), sulfameter (SM), sulfamethazine (SM2), sulfamethoxypyridazine (SMP), sulfamethoxazole (SMZ), sulfamonomethoxine (SMM), sulfadimethoxine (SDM) and sulfaquinoxaline (SQX). After solvent extraction, solid phase extraction, dilution and reversed-phase HPLC separation, SAs were detected by ESI-MS-MS under multi-reaction monitoring mode. The qualification analysis was done by using retention time and distribution of diagnostic ion pairs, and the quantification was based on the peak intensity of common fragment ion m/z 156. The limits of quantification for 10 SAs were 0.5 - 2.0 microg/kg (S/N = 10). The correlation coefficient of linear calibration curve was over 0.9995 within the SAs concentration range 2.0 - 200 microg/L except for SDM and SQX. At the spiked level of 1.0 mg/kg, the average recoveries for the 10 SAs were between 70% and 92%, the relative standard deviations were under 10% for intra-day and under 15% for inter-day. Routine tests showed the method was fast, sensitive, specific, and practical for the SAs determination in feedstuff.
[Mh] Termos MeSH primário: Ração Animal/análise
Cromatografia Líquida de Alta Pressão/métodos
Sulfonamidas/análise
Sulfonamidas/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Espectrometria de Massas por Ionização por Electrospray
Sulfadimetoxina/análise
Sulfadimetoxina/química
Sulfameter/análise
Sulfameter/química
Sulfametazina/análise
Sulfametazina/química
Sulfametoxazol/análise
Sulfametoxazol/química
Sulfametoxipiridazina/análise
Sulfametoxipiridazina/química
Sulfamonometoxina/análise
Sulfamonometoxina/química
Sulfapiridina/análise
Sulfapiridina/química
Sulfaquinoxalina/análise
Sulfaquinoxalina/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfonamides); 30CPC5LDEX (Sulfadimethoxine); 3L179F09D6 (Sulfameter); 48U51W007F (Sulfamethazine); JE42381TNV (Sulfamethoxazole); T034E4NS2Z (Sulfamethoxypyridazine); U700P169W2 (Sulfamonomethoxine); WNW8115TM9 (Sulfaquinoxaline); Y5V2N1KE8U (Sulfapyridine)
[Em] Mês de entrada:1005
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051028
[St] Status:MEDLINE


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[PMID]:8009816
[Au] Autor:Weijkamp K; Faghihi SM; Nijmeijer SM; Witkamp RF; van Miert AS
[Ad] Endereço:Department of Veterinary Basic Sciences, Utrecht University, The Netherlands.
[Ti] Título:Oral bioavailability of sulphamethoxydiazine, sulphathiazole and sulphamoxole in dwarf goats.
[So] Source:Vet Q;16(1):33-7, 1994 Mar.
[Is] ISSN:0165-2176
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To get a better insight into the oral bioavailability of sulphonamides in ruminants, sulphamethoxydiazine (pKa 7.0), sulphathiazole (pKa 7.2), and sulphamoxole (pKa 7.4) were administered to dwarf goats (n = 5). The drugs were given at 2-week intervals by the intravenous or intraruminal route at a dose of 100 mg per kg body weight. After IV injection, the mean half-life (t1/2 beta in h +/- SEM) was 0.80 +/- 0.10 h, 2.35 +/- 0.38 h, and 3.36 +/- 1.25 h, for sulphathiazole, sulphamoxole, and sulphamethoxydiazine, respectively and the mean distribution volume (Vd beta) was 0.23 +/- 0.05 l/kg, 0.23 +/- 0.04 l/kg, and 0.33 +/- 0.02 l/kg. After intraruminal administration, the mean bioavailability varied from 86.0 +/- 11.8% for sulphamethoxydiazine to 46.6 +/- 4.3% for sulphamoxole, and 52.6 +/- 7.2% for sulphathiazole. The elimination half-life was significantly prolonged, probably due to a low rate of drug absorption from the gastrointestinal tract. In contrast to chloramphenicol, the sulphonamides studied were stable when incubated in rumen fluid at 39 degrees C.
[Mh] Termos MeSH primário: Cabras/metabolismo
Sulfameter/farmacocinética
Sulfamoxol/farmacocinética
Sulfatiazóis/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Disponibilidade Biológica
Esquema de Medicação
Feminino
Meia-Vida
Injeções Intravenosas/veterinária
Absorção Intestinal
Intubação Gastrointestinal/veterinária
Masculino
Taxa de Depuração Metabólica
Rúmen
Sulfameter/administração & dosagem
Sulfamoxol/administração & dosagem
Sulfatiazóis/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfathiazoles); 3L179F09D6 (Sulfameter); HGG82XE020 (Sulfamoxole); Y7FKS2XWQH (sulfathiazole)
[Em] Mês de entrada:9407
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940301
[St] Status:MEDLINE


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Fotocópia
[PMID]:1410926
[Au] Autor:Popovici I; Danila G; Oita N; Dima F; Vasilescu M; Dorneanu V; Lazar D; Caraman C; Braha S; Popovici AT
[Ad] Endereço:Facultatea de Farmacie Iasi.
[Ti] Título:[The physicochemical characterization and therapeutic evaluation of Cicatrol].
[Ti] Título:Caracterizarea fizico-chimica si evaluarea terapeutica a produsului Cicatrol..
[So] Source:Rev Med Chir Soc Med Nat Iasi;96(1-2):57-64, 1992 Jan-Jun.
[Is] ISSN:0048-7848
[Cp] País de publicação:Romania
[La] Idioma:rum
[Ab] Resumo:Cicatrol ointment with the formula: argentic sulphamethoxydiasine 1 g, bentonite hydrogel 12.5% for 100 g is manufactured at the Microproduction Laboratory of the Faculty of Pharmacy of Iasi. The one-year physicochemical determinations of the aspect, colour, homogeneity, pH, rheological behaviour and relative viscosity, content in argentic sulphamethoxydiasine as well as "in vitro" antimicrobial activity of Cicatrol showed a good stability and gel properties enabling an uniform and long-term contact with the wound. The clinical investigations carried out until now in patients with burns, varicose ulcers, trophic shank ulcers, superficial phlebitis with atonic ulcerations or wounds with multiple sites revealed its remarkable therapeutic value. As compared to other similar products, Cicatrol by its aseptic properties favours the scarring of any type of wound, a normal skin, without keloid scars being obtained, it also being well tolerated.
[Mh] Termos MeSH primário: Ácido Pantotênico/química
Sulfameter/química
[Mh] Termos MeSH secundário: Queimaduras/tratamento farmacológico
Carboximetilcelulose Sódica
Fenômenos Químicos
Química Física
Combinação de Medicamentos
Avaliação de Medicamentos
Estabilidade de Medicamentos
Glicerol
Seres Humanos
Concentração de Íons de Hidrogênio
Úlcera da Perna/tratamento farmacológico
Testes de Sensibilidade Microbiana
Pomadas
Ácido Pantotênico/farmacologia
Ácido Pantotênico/uso terapêutico
Compostos de Prata
Sulfameter/farmacologia
Sulfameter/uso terapêutico
Úlcera Varicosa/tratamento farmacológico
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Ointments); 0 (Silver Compounds); 123774-77-6 (calcium pantothenate, carboxymethylcellulose, glycerin, silver sulfameter, xylene drug combination); 19F5HK2737 (Pantothenic Acid); 3L179F09D6 (Sulfameter); K679OBS311 (Carboxymethylcellulose Sodium); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:9211
[Cu] Atualização por classe:161123
[Lr] Data última revisão:
161123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920101
[St] Status:MEDLINE



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