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Pesquisa : D02.065.884.725.867 [Categoria DeCS]
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[PMID]:28278773
[Au] Autor:Feng Y; Liao C; Li H; Liu C; Shih K
[Ad] Endereço:a Department of Civil Engineering , The University of Hong Kong , Hong Kong.
[Ti] Título:Cu O-promoted degradation of sulfamethoxazole by α-Fe O -catalyzed peroxymonosulfate under circumneutral conditions: synergistic effect, Cu/Fe ratios, and mechanisms.
[So] Source:Environ Technol;39(1):1-11, 2018 Jan.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To promote the application of iron oxides in sulfate radical-based advanced oxidation processes, a convenient approach using Cu O as a catalyst additive was proposed. Composite catalysts based on α-Fe O (CTX%Cu O, X = 1, 2.5, 5, and 10) were prepared for peroxymonosulfate (PMS) activation, and sulfamethoxazole was used as a model pollutant to probe the catalytic reactivity. The results show that a synergistic catalytic effect exists between Cu O and α-Fe O , which was explained by the promoted reduction of Fe(III) by Cu(I). Iron K-edge X-ray absorption spectroscopy investigations indicated that the promoted reduction probably occurred with PMS acting as a ligand that bridges the redox centers of Cu(I) and Fe(III). The weight ratio between Cu O and α-Fe O influenced the degradation of sulfamethoxazole, and the optimal ratio depended on the dosage of PMS and catalysts. With 40 mg L PMS and 0.6 g L catalyst, a pseudo-first-order constant of ∼0.019 min was achieved for CT2.5%Cu O, whereas only 0.004 min was realized for α-Fe O . Nearly complete degradation of the sulfamethoxazole was achieved within 180 min under the conditions of 40 mg L PMS, 0.4 g L CT2.5%Cu O, and pH 6.8. In contrast, less than 20% degradation was realized with α-Fe O under similar conditions. The CT2.5%Cu O catalyst had the best stoichiometric efficiency of PMS (0.317), which was 4.5 and 5.8 times higher than those of Cu O (0.070) and α-Fe O (0.054), respectively. On the basis of the products identified, the cleavage of the S-N bond was proposed as a major pathway for the degradation of sulfamethoxazole.
[Mh] Termos MeSH primário: Modelos Químicos
Sulfametoxazol/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Cobre/química
Compostos Férricos/química
Ferro/química
Peróxidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Peroxides); 0 (Water Pollutants, Chemical); 1K09F3G675 (ferric oxide); 22047-43-4 (peroxymonosulfate); 789U1901C5 (Copper); E1UOL152H7 (Iron); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1293164


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[PMID]:29268104
[Au] Autor:Geng C; Bergheaud V; Garnier P; Zhu YG; Haudin CS
[Ad] Endereço:UMR ECOSYS, INRA, AgroParisTech, Université Paris-Saclay, 78850, Thiverval-Grignon, France; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, China.
[Ti] Título:Impact of sludge treatments on the extractability and fate of acetyl sulfamethoxazole residues in amended soils.
[So] Source:Chemosphere;194:828-836, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sludge recycled in agriculture may bring antibiotics into cropped soils. The nature, total amount, and availability of the antibiotics in soil partly depend on the sludge treatments. Our paper compares the fate of N-acetyl sulfamethoxazole (AC-SMX) residues between soils incubated with the same sludge but submitted to different processes before being added in soil. The fate of C-AC-SMX residues was studied in mixtures of soil and sludges at different treatment levels: 1) activated and 2) centrifuged sludges, both enriched with C-AC-SMX, and 3) limed and 4) heat-dried sludges obtained by treating the previously contaminated centrifuged sludge. The evolution of the extractability of C residues (CaCl , methanol) and their mineralization were followed during 119 days. More than 80% of the initial C-activity was no longer extractable after 14 days, except in soil with limed sludge. Liming and drying the centrifuged sludge decreased the mineralized C fraction from 5.7-6.4% to 1.2-1.8% and consequently, the corresponding soils contained more C residues after 119 days. Although C residues were more CaCl -extractable in soil with limed sludge, they seemed to be poorly bioavailable for biodegradation. For all solid sludges, the mineralization rate of C-AC-SMX residues was strongly correlated to that of sludge organic carbon, with a coefficient three times lower for the limed and dried sludges than for the centrifuged sludge after 14 days.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Esgotos/química
Poluentes do Solo/química
Solo/química
Sulfametoxazol/química
[Mh] Termos MeSH secundário: Agricultura/métodos
Compostos de Cálcio
Radioisótopos de Carbono
Dessecação
Recuperação e Remediação Ambiental/métodos
Minerais
Óxidos
Esgotos/microbiologia
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Calcium Compounds); 0 (Carbon Radioisotopes); 0 (Minerals); 0 (Oxides); 0 (Sewage); 0 (Soil); 0 (Soil Pollutants); C7X2M0VVNH (lime); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29406107
[Au] Autor:Li X; Yuan H; Quan X; Chen S; You S
[Ad] Endereço:Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Ling gong Road 2, Dalian 116024, China.
[Ti] Título:Effective adsorption of sulfamethoxazole, bisphenol A and methyl orange on nanoporous carbon derived from metal-organic frameworks.
[So] Source:J Environ Sci (China);63:250-259, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nanoporous carbons (NPCs) derived from metal-organic frameworks (MOFs) are attracting increasing attention in many areas by virtue of their high specific surface area, large pore volume and unique porosity. The present work reports the preparation of an NPC with high surface area (1731m /g) and pore volume (1.68cm /g) by direct carbonization of MOF-5. We examined the adsorption of three typical contaminants from aqueous solutions, i.e., sulfamethoxazole (SMX), bisphenol A (BPA) and methyl orange (MO), by using the as-prepared NPC. The results demonstrated that NPC could adsorb the contaminants effectively, with adsorption capacity (q ) of 625mg/g (SMX), 757mg/g (BPA) and 872mg/g (MO), respectively. These values were approximately 1.0-3.2 times higher than those obtained for single-walled carbon nanotubes (SWCNTs) and commercial powder active carbon (PAC) under the same conditions. With its high surface area and unique meso/macropore structure, the enhanced adsorption of NPC most likely originates from the cooperative interaction of a pore-filling mechanism, electrostatic interaction, and hydrogen bonding. In particular, the pH value has a crucial impact on adsorption, suggesting the significant contribution of electrostatic interaction between NPC and the contaminants. This study provides a proof-of-concept demonstration of MOF-derived nanoporous carbons as effective adsorbents of contaminants for water treatment.
[Mh] Termos MeSH primário: Compostos Azo/química
Estruturas Metalorgânicas/química
Sulfametoxazol/química
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Compostos Azo/análise
Compostos Benzidrílicos
Carvão Vegetal
Concentração de Íons de Hidrogênio
Cinética
Nanoporos
Nanotubos de Carbono/química
Fenóis
Porosidade
Sulfametoxazol/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Benzhydryl Compounds); 0 (Metal-Organic Frameworks); 0 (Nanotubes, Carbon); 0 (Phenols); 0 (Water Pollutants, Chemical); 16291-96-6 (Charcoal); 6B4TC34456 (methyl orange); JE42381TNV (Sulfamethoxazole); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29293328
[Au] Autor:Bhalsod GD; Chuang YH; Jeon S; Gui W; Li H; Ryser ET; Guber AK; Zhang W
[Ad] Endereço:Cook County Unit, University of Illinois Extension , Arlington Heights, Illinois 60004, United States.
[Ti] Título:Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce.
[So] Source:J Agric Food Chem;66(4):822-830, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the uptake and accumulation of pharmaceuticals in vegetables under typical irrigation practices is critical to risk assessment of crop irrigation with reclaimed water. This study investigated the pharmaceutical residues in greenhouse lettuce under overhead and soil-surface irrigations using pharmaceutical-contaminated water. Compared to soil-surface irrigation, overhead irrigation substantially increased the pharmaceutical residues in lettuce shoots. The increased residue levels persisted even after washing for trimethoprim, monensin sodium, and tylosin, indicating their strong sorption to the shoots. The postwashing concentrations in fresh shoots varied from 0.05 ± 0.04 µg/kg for sulfadiazine to 345 ± 139 µg/kg for carbamazepine. Root concentration factors ranged from 0.04 ± 0.14 for tylosin to 19.2 ± 15.7 for sulfamethoxazole. Translocation factors in surface-irrigated lettuce were low for sulfamethoxalzole, trimethoprim, monensin sodium, and tylosin (0.07-0.15), but high for caffeine (4.28 ± 3.01) and carbamazepine (8.15 ± 2.87). Carbamazepine was persistent in soil and hyperaccumulated in shoots.
[Mh] Termos MeSH primário: Irrigação Agrícola/métodos
Resíduos de Drogas/análise
Alface/metabolismo
Preparações Farmacêuticas/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Carbamazepina/análise
Contaminação de Alimentos
Alface/química
Monensin/análise
Preparações Farmacêuticas/análise
Folhas de Planta/química
Raízes de Plantas/química
Solo/química
Poluentes do Solo/análise
Poluentes do Solo/metabolismo
Sulfametoxazol/análise
Trimetoprima/análise
Tilosina/análise
Verduras
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Soil); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 33CM23913M (Carbamazepine); 906O0YJ6ZP (Monensin); AN164J8Y0X (Trimethoprim); JE42381TNV (Sulfamethoxazole); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04355


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[PMID]:29107874
[Au] Autor:Li S; Huang Z; Wang Y; Liu YQ; Luo R; Shang JG; Liao QJ
[Ad] Endereço:Department of Environmental Science, China Pharmaceutical University, Nanjing 211198, China.
[Ti] Título:Migration of two antibiotics during resuspension under simulated wind-wave disturbances in a water-sediment system.
[So] Source:Chemosphere;192:234-243, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the migration of antibiotics (norfloxacin, NOR; and sulfamethoxazole, SMX) under simulated resuspension conditions across the sediment-water interface were quantified for two locations in China: point A, located in Meiliang Bay of Lake Taihu, and point B, located in Dapukou of Lake Taihu. The concentrations of suspended solids (SS) in the overlying water amounted to 100, 500, and 1000 mg/L during background, moderate, and strong simulated wind-wave disturbances, respectively. At each SS level, the initial concentrations of the two antibiotics were set to 1, 5, and 10 mg/L. The results showed that both resuspended SS and the initial concentration of antibiotics could influence the migration of NOR in the water-sediment system. Specifically, both higher SS and initial antibiotic concentrations were associated with higher rates of migration and accumulation of NOR from water to sediment. In contrast, the migration of SMX in the water-sediment system was not impacted by SS or initial antibiotic concentration. The adsorption capacities of sediments for NOR and SMX were significantly different at both locations, possibly reflecting differences in cation exchange capacity (CEC) and organic material (OM) contents. In general, higher CEC and OM values were found in sediments with a higher adsorption capacity for the antibiotics. When CEC and OM values of sediments were higher, the adsorption capacity reached up to 51.73 mg/kg. Large differences in the migration from water to sediment were observed for the two antibiotics, with NOR migration rates higher than those of SMX. The accumulation of NOR in surface sediment during resuspension was about 14 times higher than that of SMX. The main reason for this is that the chemical adsorption of NOR is seldom reversible. Overall, this study demonstrates that resuspension of NOR and SMX attached to sediments under simulated wind-wave disturbances can promote the migration of the antibiotics from water to sediment; these results could be useful for assessing the migration and fate of commonly used antibiotics in water-sediment systems.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Sedimentos Geológicos/química
Norfloxacino/metabolismo
Sulfametoxazol/metabolismo
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Adsorção
China
Lagos/química
Suspensões/análise
Suspensões/química
Água/análise
Água/química
Vento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Suspensions); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); JE42381TNV (Sulfamethoxazole); N0F8P22L1P (Norfloxacin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE


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[PMID]:29102867
[Au] Autor:Murillo-Sierra JC; Sirés I; Brillas E; Ruiz-Ruiz EJ; Hernández-Ramírez A
[Ad] Endereço:Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Av. Universidad, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, Mexico.
[Ti] Título:Advanced oxidation of real sulfamethoxazole + trimethoprim formulations using different anodes and electrolytes.
[So] Source:Chemosphere;192:225-233, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A commercial sulfamethoxazole + trimethoprim formulation has been degraded in 0.050 M Na SO at pH 3.0 by electrochemical oxidation with electrogenerated H O (EO-H O ), electro-Fenton (EF), photoelectro-Fenton with a 6-W UVA lamp (PEF) and solar photoelectro-Fenton (SPEF). The tests were performed in an undivided cell with an IrO -based, Pt or boron-doped diamond (BDD) anode and an air-diffusion cathode for H O electrogeneration. The anode material had little effect on the accumulated H O concentration. Both drugs always obeyed a pseudo-first-order decay with low apparent rate constant in EO-H O . Much higher values were found in EF, PEF and SPEF, showing no difference because the main oxidant was always OH formed from Fenton's reaction between H O and added Fe . The solution mineralization increased in the sequence EO-H O < EF < PEF < SPEF regardless of the anode. The IrO -based and Pt anodes behaved similarly but BDD was always more powerful. In SPEF, similar mineralization profiles were found for all anodes because of the rapid removal of photoactive intermediates by sunlight. About 87% mineralization was obtained as maximum for the powerful SPEF with BDD anode. Addition of Cl enhanced the decay of both drugs due to their quicker reaction with generated active chlorine, but the formation of persistent chloroderivatives decelerated the mineralization process. Final carboxylic acids like oxalic and oxamic were detected, yielding Fe(III) complexes that remained stable in EF with BDD but were rapidly photolyzed in SPEF with BDD, explaining its superior mineralization ability.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Água Doce/química
Sulfametoxazol/química
Trimetoprima/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Boro/química
Diamante/química
Eletroquímica
Eletrodos
Compostos Férricos/química
Água Doce/análise
Peróxido de Hidrogênio/química
Oxirredução
Fotólise
Luz Solar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Ferric Compounds); 0 (Water Pollutants, Chemical); 7782-40-3 (Diamond); AN164J8Y0X (Trimethoprim); BBX060AN9V (Hydrogen Peroxide); JE42381TNV (Sulfamethoxazole); N9E3X5056Q (Boron)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171106
[St] Status:MEDLINE


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[PMID]:28958376
[Au] Autor:Yarmohammadi H; Cunningham-Rundles C
[Ad] Endereço:Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: hale.yar@mssm.edu.
[Ti] Título:Idiopathic CD4 lymphocytopenia: Pathogenesis, etiologies, clinical presentations and treatment strategies.
[So] Source:Ann Allergy Asthma Immunol;119(4):374-378, 2017 Oct.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Idiopathic CD4 lymphocytopenia (ICL) is a rare condition characterized by an unexplained deficit of circulating CD4 T cells leading to increased risk of serious opportunistic infections. The pathogenesis, etiology, clinical presentation, and best treatment options remain unclear. OBJECTIVE: To describe the clinical presentation, treatment strategies, and outcome of patients with ICL seen in a single referral center. METHODS: In a retrospective study, from January 1993 to January 2014, the demographic characteristics, clinical presentation, and treatments of patients diagnosed with ICL were reviewed. RESULTS: Twenty-four patients (14 female [58%] and 10 male [42%]) were evaluated. The mean age was 45 ± 17.6 years (range 7-76 years). Mean CD4 and CD8 T-cell counts at the time of diagnosis were 119 ± 84/mm (range 4-294/mm ) and 219 ± 258/mm (range 7-630/mm ), respectively. Seventeen patients (71%) had opportunistic infections, 4 (17%) had malignancies, and 3 (13%) had unexplained demyelinating disease and neurologic problems. Most patients had normal levels of immunoglobulins. Thirteen patients had abnormally low to absent response to phytohemagglutinin, concanavalin A, and antigens (candida and tetanus). Three patients had resolution of warts and 1 had mycobacterial lung infection on interleukin-2 with increases in CD4 count. The 11 patients on trimethoprim and sulfamethoxazole had no further hospital admissions for infections. CONCLUSION: The pathogenesis of ICL remains unclear. Although only some patients are healthy, most patients present with opportunistic infections. There is no known standard treatment aside from prophylactic antibiotics.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Doenças Desmielinizantes/tratamento farmacológico
Neoplasias/tratamento farmacológico
Infecções Oportunistas/tratamento farmacológico
T-Linfocitopenia Idiopática CD4-Positiva/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Contagem de Linfócito CD4
Linfócitos T CD4-Positivos/efeitos dos fármacos
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD4-Positivos/patologia
Linfócitos T CD8-Positivos/efeitos dos fármacos
Linfócitos T CD8-Positivos/imunologia
Linfócitos T CD8-Positivos/patologia
Criança
Doenças Desmielinizantes/complicações
Doenças Desmielinizantes/diagnóstico
Doenças Desmielinizantes/imunologia
Gerenciamento Clínico
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias/complicações
Neoplasias/diagnóstico
Neoplasias/imunologia
Infecções Oportunistas/complicações
Infecções Oportunistas/diagnóstico
Infecções Oportunistas/imunologia
Estudos Retrospectivos
Sulfametoxazol/uso terapêutico
T-Linfocitopenia Idiopática CD4-Positiva/complicações
T-Linfocitopenia Idiopática CD4-Positiva/diagnóstico
T-Linfocitopenia Idiopática CD4-Positiva/imunologia
Trimetoprima/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); AN164J8Y0X (Trimethoprim); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


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[PMID]:28797073
[Au] Autor:Chen HR; Rairat T; Loh SH; Wu YC; Vickroy TW; Chou CC
[Ad] Endereço:Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.
[Ti] Título:Assessment of veterinary drugs in plants using pharmacokinetic approaches: The absorption, distribution and elimination of tetracycline and sulfamethoxazole in ephemeral vegetables.
[So] Source:PLoS One;12(8):e0183087, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study was carried out to demonstrate novel use of pharmacokinetic approaches to characterize drug behaviors/movements in the vegetables with implications to food safety. The absorption, distribution, metabolism and most importantly, the elimination of tetracycline (TC) and sulfamethoxazole (SMX) in edible plants Brassica rapa chinensis and Ipomoea aquatica grown hydroponically were demonstrated and studied using non-compartmental pharmacokinetic analysis. The results revealed drug-dependent and vegetable-dependent pharmacokinetic differences and indicated that ephemeral vegetables could have high capacity accumulating antibiotics (up to 160 µg g-1 for TC and 38 µg g-1 for SMX) within hours. TC concentration in the root (Cmax) could reach 11 times higher than that in the cultivation fluid and 3-28 times higher than the petioles/stems. Based on the volume of distribution (Vss), SMX was 3-6 times more extensively distributed than TC. Both antibiotics showed evident, albeit slow elimination phase with elimination half-lives ranging from 22 to 88 hours. For the first time drug elimination through the roots of a plant was demonstrated, and by viewing the root as a central compartment and continuous infusion without a loading dose as drug administration mode, it is possible to pharmacokinetically monitor the movement of antibiotics and their fate in the vegetables with more detailed information not previously available. Phyto-pharmacokinetic could be a new area worth developing new models for the assessment of veterinary drugs in edible plants.
[Mh] Termos MeSH primário: Anti-Infecciosos/metabolismo
Brassica rapa/metabolismo
Spinacia oleracea/metabolismo
Sulfametoxazol/metabolismo
Tetraciclina/metabolismo
Verduras/metabolismo
Drogas Veterinárias/metabolismo
[Mh] Termos MeSH secundário: Anti-Infecciosos/análise
Contaminação de Alimentos/análise
Sulfametoxazol/análise
Tetraciclina/análise
Drogas Veterinárias/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Veterinary Drugs); F8VB5M810T (Tetracycline); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183087


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[PMID]:28780269
[Au] Autor:Zhang S; Yang XL; Li H; Song HL; Wang RC; Dai ZQ
[Ad] Endereço:School of Energy and Environment, Southeast University, Nanjing 210096, China. Electronic address: zhangshuai198702@163.com.
[Ti] Título:Degradation of sulfamethoxazole in bioelectrochemical system with power supplied by constructed wetland-coupled microbial fuel cells.
[So] Source:Bioresour Technol;244(Pt 1):345-352, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The removal rate and degradation pathway of Sulfamethoxazole (SMX) in bioelectrochemical system (BES) and the elimination dynamics of SMX in a BES driven by stacked constructed wetland-coupled microbial fuel cells (CW-MFCs) were investigated. The results found that SMX (30mgL ) was rapidly degraded in the BES, and the SMX removal kinetics was simulated well by a first-order kinetic model (R >0.93). Low current had no effect on the degradation products but enhanced the SMX removal rate. Biotransformation was the main pathway for the SMX elimination in the BES. The CW-MFCs supplied adequate and stable electricity (0.84-1.01V) to support the BES for rapid SMX degradation without additional energy inputs. The relative abundance of Methanosarcina (18.7%) and VadinCA11 (3.1%) increased with an increase in voltage up to 1.2V. However, the opposite was observed for Methanosaeta and Methanomassiliicoccus. The current in the BES influenced the methanogenic communities.
[Mh] Termos MeSH primário: Fontes de Energia Bioelétrica
Sulfametoxazol
[Mh] Termos MeSH secundário: Biotransformação
Eletricidade
Zonas Úmidas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


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[PMID]:28771141
[Au] Autor:Herrera-Heredia SA; Pezina-Cantú C; Garza-González E; Bocanegra-Ibarias P; Mendoza-Olazarán S; Morfín-Otero R; Camacho-Ortiz A; Villarreal-Treviño L; Rodríguez-Noriega E; Paláu-Davila L; Maldonado-Garza HJ; Flores-Treviño S
[Ad] Endereço:1​Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
[Ti] Título:Risk factors and molecular mechanisms associated with trimethoprim-sulfamethoxazole resistance in Stenotrophomonas maltophilia in Mexico.
[So] Source:J Med Microbiol;66(8):1102-1109, 2017 Aug.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Stenotrophomonas maltophilia is a multidrug-resistant opportunistic pathogen causing an increasing number of nosocomial infections. Our aim was to evaluate the risk factors and mechanisms associated with trimethoprim-sulfamethoxazole (SXT) resistance in S. maltophilia infections in Mexico. METHODOLOGY: Clinical isolates and patients' demographic and clinical data were collected from February 2007 to August 2015 in two tertiary-care hospitals in Mexico. Antimicrobial susceptibility and analysis of sul and SmeABC and SmeDEF efflux pump overexpression were performed in all isolates.Results/Key findings. In the 9-year period, 196 patients infected with S. maltophilia were identified. Most patients were male, and the mean age was 46.2 years. The mean Charlson score was 1.42, and the most frequent comorbidities were arterial hypertension (26.7 %), type 2 diabetes (21.2 %) and cerebral infarction (11.6 %). High drug resistance to meropenem (93.4 %), gentamicin (55.1 %), ceftazidime (52.3 %), cefotaxime (51.5 %), amikacin (42.3 %) and cefepime (32.1 %), and lower resistance to ciprofloxacin (26.0 %), SXT (25.0 %), chloramphenicol (14.3 %) and levofloxacin (2.6 %) were detected. SXT resistance was not associated with the sul genes. SmeABC overexpression was associated with gentamicin (P=0.001) and levofloxacin resistance (P=0.041), whereas SmeDEF overexpression was associated with ceftazidime resistance (P=0.003). Prolonged hospitalization (≥15 days) was an independent risk factor for SXT-resistant S. maltophilia infections (OR=3.05; 95 % CI=1.12-8.86; P=0.029). CONCLUSION: Given the high SXT resistance rate, SXT is not an effective first-line therapy for our patients; instead, levofloxacin could be used as an appropriate therapeutic option against S. maltophilia infections.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla
Infecções por Bactérias Gram-Negativas/microbiologia
Stenotrophomonas maltophilia/efeitos dos fármacos
Sulfametoxazol/farmacologia
Trimetoprima/farmacologia
[Mh] Termos MeSH secundário: Adulto
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Infecção Hospitalar
Feminino
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Seres Humanos
Masculino
México
Testes de Sensibilidade Microbiana
Meia-Idade
Stenotrophomonas maltophilia/classificação
Stenotrophomonas maltophilia/genética
Stenotrophomonas maltophilia/isolamento & purificação
Combinação Trimetoprima e Sulfametoxazol
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); AN164J8Y0X (Trimethoprim); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000550



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