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[PMID]:29190037
[Au] Autor:Bonet M; Ota E; Chibueze CE; Oladapo OT
[Ad] Endereço:UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research, World Health Organization, Avenue Appia 20, Geneva, Switzerland, CH-1211.
[Ti] Título:Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity.
[So] Source:Cochrane Database Syst Rev;11:CD012137, 2017 11 13.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Infectious morbidities contribute to considerable maternal and perinatal morbidity and mortality, including women at no apparent increased risk of infection. To reduce the incidence of infections, antibiotics are often administered to women after uncomplicated childbirth, particularly in settings where women are at higher risk of puerperal infectious morbidities. OBJECTIVES: To assess whether routine administration of prophylactic antibiotics to women after normal (uncomplicated) vaginal birth, compared with placebo or no antibiotic prophylaxis, reduces postpartum maternal infectious morbidities and improves outcomes. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2017), LILACS, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (22 August 2017) and reference lists of retrieved studies. SELECTION CRITERIA: We planned to include randomised or quasi-randomised trials evaluating the use of prophylactic antibiotics versus placebo or no antibiotic prophylaxis. Trials using a cluster-randomised design would have been eligible for inclusion, but we found none.In future updates of this review, we will include studies published in abstract form only, provided sufficient information is available to assess risks of bias. We will consider excluded abstracts for inclusion once the full publication is available, or the authors provide more information.Trials using a cross-over design are not eligible for inclusion in this review. DATA COLLECTION AND ANALYSIS: Two review authors conducted independent assessment of trials for inclusion and risks of bias. They independently extracted data and checked them for accuracy, resolving differences in assessments by discussion. They evaluated methodological quality using standard Cochrane criteria and the GRADE approach.We present the summaries as risk ratios (RRs) and mean difference (MDs) using fixed- or random-effect models. For one primary outcome we found considerable heterogeneity and interaction. We explored further using subgroup analysis to investigate the effects of the randomisation unit. All review authors discussed and interpreted the results. MAIN RESULTS: One randomised controlled trial (RCT) and two quasi-RCTs contributed data on 1779 women who had uncomplicated vaginal births, comparing different antibiotic regimens with placebo or no treatment. The included trials took place in the 1960s (one trial) and 1990s (two trials). The trials were conducted in France, the USA and Brazil. Antibiotics administered included: oral sulphamethoxypyridazine or chloramphenicol for three to five days, and intravenous amoxicillin and clavulanic acid in a single dose one hour after birth. We rated most of the domains for risk of bias as high risk, with the exception of reporting bias and other potential bias.The quality of evidence ranged from low to very low, based on the GRADE quality assessment, given very serious design limitations of the included studies, few events and wide confidence intervals (CIs) of effect estimates.We found a decrease in the risk of endometritis (RR 0.28, 95% CI 0.09 to 0.83, two trials, 1364 women,very low quality). However, one trial reported zero events for this outcome and we rate the evidence as very low quality. There was little or no difference between groups for the risk of urinary tract infection (RR 0.25, 95% CI 0.05 to 1.19, two trials, 1706 women,low quality), wound infection after episiotomy (reported as wound dehiscence in the included trials) (RR 0.78, 95% CI 0.31 to 1.96, two trials, 1364 women, very low quality) and length of maternal hospital stay in days (MD -0.15, 95% CI -0.31 to 0.01, one trial, 1291 women, very low quality). Cost of care in US dollar equivalent was 2½ times higher in the control group compared to the group receiving antibiotics prophylaxis (USD 3600: USD 9000, one trial, 1291 women). There were few or no differences between treated and control groups for adverse effects of antibiotics (skin rash) reported in one woman in each of the two trials (RR 3.03, 95% CI 0.32 to 28.95, two trials, 1706 women, very low quality). The incidence of severe maternal infectious morbidity, antimicrobial resistance or women's satisfaction with care were not addressed by any of the included studies. AUTHORS' CONCLUSIONS: Routine administration of antibiotics may reduce the risk of endometritis after uncomplicated vaginal birth. The small number and nature of the trials limit the interpretation of the evidence for application in practice, particularly in settings where women may be at higher risk of developing endometritis. The use of antibiotics did not reduce the incidence of urinary tract infections, wound infection or the length of maternal hospital stay. Antibiotics are not a substitute for infection prevention and control measures around the time of childbirth and the postpartum period. The decision to routinely administer prophylactic antibiotics after normal vaginal births needs to be balanced by patient features, childbirth setting and provider experience, including considerations of the contribution of indiscriminate use of antibiotics to raising antimicrobial resistance. Well-designed and high-powered randomised controlled trials would help to evaluate the added value of routine antibiotic administration as a measure to prevent maternal infections after normal vaginal delivery.
[Mh] Termos MeSH primário: Antibioticoprofilaxia
Parto Obstétrico
Endometrite/prevenção & controle
Infecção Puerperal/prevenção & controle
[Mh] Termos MeSH secundário: Amoxicilina/administração & dosagem
Antibacterianos/administração & dosagem
Cloranfenicol/administração & dosagem
Ácido Clavulânico/administração & dosagem
Endometrite/epidemiologia
Episiotomia/efeitos adversos
Feminino
Seres Humanos
Ensaios Clínicos Controlados não Aleatórios como Assunto
Gravidez
Infecção Puerperal/epidemiologia
Ensaios Clínicos Controlados Aleatórios como Assunto
Sulfametoxipiridazina/administração & dosagem
Infecção da Ferida Cirúrgica/epidemiologia
Infecção da Ferida Cirúrgica/prevenção & controle
Infecções Urinárias/epidemiologia
Infecções Urinárias/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 23521W1S24 (Clavulanic Acid); 66974FR9Q1 (Chloramphenicol); 804826J2HU (Amoxicillin); T034E4NS2Z (Sulfamethoxypyridazine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD012137.pub2


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[PMID]:28647269
[Au] Autor:Shah S; Hao C
[Ad] Endereço:State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China; Department of Chemistry, Karakorum International University, Gilgit-Baltistan 15100, Pakistan.
[Ti] Título:Quantum chemical investigation on photodegradation mechanisms of sulfamethoxypyridazine with dissolved inorganic matter and hydroxyl radical.
[So] Source:J Environ Sci (China);57:85-92, 2017 Jul.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sulfamethoxypyridazine (SMP) is one of the commonly used sulfonamide antibiotics (SAs). SAs are mainly studied to undergo triplet-sensitized photodegradation in water under natural sunlight with other coexisting aquatic environmental organic pollutants. In this work, SMP was selected as a representative of SAs. We studied the mechanisms of triplet-sensitized photodegradation of SMP and the influence of selected dissolved inorganic matter, i.e., anions (Br , Cl , and NO ) and cations ions (Ca , Mg , and Zn ) on SMP photodegradation mechanism by quantum chemical methods. In addition, the degradation mechanisms of SMP by hydroxyl radical (OH) were also investigated. The creation of SO extrusion product was accessed with two different energy pathways (pathway-1 and pathway-2) by following two steps (step-I and step-II) in the triplet-sensitized photodegradation of SMP. Due to low activation energy, the pathway-1 was considered as the main pathway to obtain SO extrusion product. Step-II of pathway-1 was measured to be the rate-limiting step (RLS) of SMP photodegradation mechanism and the effect of the selected anions and cations was estimated for this step. All selected anions and cations promoted photodegradation of SMP by dropping the activation energy of pathway-1. The estimated low activation energies of different degradation pathways of SMP with OH radical indicate that OH radical is a very powerful oxidizing agent for SMP degradation via attack through benzene derivative and pyridazine derivative ring.
[Mh] Termos MeSH primário: Modelos Químicos
Fotólise
Sulfametoxipiridazina/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Radical Hidroxila
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 3352-57-6 (Hydroxyl Radical); T034E4NS2Z (Sulfamethoxypyridazine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


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[PMID]:27063329
[Au] Autor:Liu A; Dong L; Wei XL; Yang XH; Xiao JH; Liu ZQ
[Ad] Endereço:School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
[Ti] Título:Development of amino- and dimethylcarbamate-substituted resorcinol as programmed cell death-1 (PD-1) inhibitor.
[So] Source:Eur J Pharm Sci;88:50-8, 2016 Jun 10.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Blockading the interaction of programmed death-1 (PD-1) protein with its ligands (PD-Ls, such as PD-L1) was proved to be a pathway for suppressing the development of tumors and other degradations of biological species. Thus, finding PD-1 inhibitors situated at the convergence point of drug discovery. In addition to some monoclonal antibodies applied to treat cancers clinically, the screening of organic molecules for hindering the interaction of PD-1 with PD-L1 became an efficient strategy in the development of PD-1 inhibitors. We herein applied resorcinol and 3-hydroxythiophenol as the core to link with N,N-dimethylcarbamate and other alkyl-substituted amines to afford 13 amine-appended phenyl dimethylcarbamates (AAPDs). The test for blockading the combination of PD-1 with PD-L1 revealed that abilities of 13 AAPDs were higher than that of sulfamethizole, a successful PD-1 inhibitor. In particular, large hydrophobic substituents at amine moiety or a nitro at resorcinol skeleton enhanced the inhibitory effect of AAPD even higher than that of sulfamethoxypyridazine, another successful PD-1 inhibitor. The present results may provide valuable information for further investigation on synthetic PD-1 inhibitors.
[Mh] Termos MeSH primário: Aminoácidos/química
Antineoplásicos/síntese química
Antineoplásicos/farmacologia
Receptor de Morte Celular Programada 1/antagonistas & inibidores
Resorcinóis/química
Resorcinóis/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/química
Desenho de Drogas
Estrutura Molecular
Imagem Óptica
Relação Estrutura-Atividade
Sulfametizol/química
Sulfametizol/farmacologia
Sulfametoxipiridazina/química
Sulfametoxipiridazina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Antineoplastic Agents); 0 (Programmed Cell Death 1 Receptor); 0 (Resorcinols); 25W8454H16 (Sulfamethizole); T034E4NS2Z (Sulfamethoxypyridazine); YUL4LO94HK (resorcinol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE


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[PMID]:26992512
[Au] Autor:Tolmacheva VV; Apyari VV; Furletov AA; Dmitrienko SG; Zolotov YA
[Ad] Endereço:Analytical Chemistry Division, Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia.
[Ti] Título:Facile synthesis of magnetic hypercrosslinked polystyrene and its application in the magnetic solid-phase extraction of sulfonamides from water and milk samples before their HPLC determination.
[So] Source:Talanta;152:203-10, 2016 May 15.
[Is] ISSN:1873-3573
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, a novel magnetic solid-phase extraction (MSPE) sorbent, magnetic hypercrosslinked polystyrene (HCP/Fe3O4), was prepared and used for preconcentration of four sulfonamides (sulfamethoxypyridazine, sulfamethazine, sulfamethoxazole and sulfachloropyridazine) from natural water and milk samples. This material was prepared by sorption of pre-synthesized Fe3O4 nanoparticles (NPs) onto HCP. A number of sorbents with varying Fe3O4NPs content were prepared, and their structural, magnetic and sorption properties were studied. Various experimental parameters affecting the extraction efficiencies such as the amount of the magnetic nanocomposite, extraction time, pH of the sample solution and desorption conditions were studied and optimized. Under the optimal conditions, a convenient and efficient method for the determination of sulfonamides in water and milk samples was developed by combining MSPE and high-performance liquid chromatography with amperometric detection. The results showed that the recoveries of these compounds were in the range of 84-105% with the relative standard deviations ranging between 3% and 10%; the limit of detection were in the range of 0.21-0.33 ng mL(-1) for water and 2.0-2.5 ng mL(-1) for milk.
[Mh] Termos MeSH primário: Nanopartículas de Magnetita/química
Poliestirenos/química
Sulfacloropiridazina/isolamento & purificação
Sulfametazina/isolamento & purificação
Sulfametoxazol/isolamento & purificação
Sulfametoxipiridazina/isolamento & purificação
Poluentes Químicos da Água/isolamento & purificação
[Mh] Termos MeSH secundário: Adsorção
Animais
Cromatografia Líquida de Alta Pressão
Técnicas Eletroquímicas
Óxido Ferroso-Férrico/química
Água Doce/química
Concentração de Íons de Hidrogênio
Cinética
Limite de Detecção
Leite/química
Extração em Fase Sólida/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Magnetite Nanoparticles); 0 (Polystyrenes); 0 (Water Pollutants, Chemical); 48U51W007F (Sulfamethazine); JE42381TNV (Sulfamethoxazole); P78D9P90C0 (Sulfachlorpyridazine); T034E4NS2Z (Sulfamethoxypyridazine); XM0M87F357 (Ferrosoferric Oxide)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160320
[St] Status:MEDLINE


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[PMID]:24394532
[Au] Autor:Rajendiran N; Venkatesh G; Mohandass T
[Ad] Endereço:Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamilnadu, India. Electronic address: drrajendiran@rediffmail.com.
[Ti] Título:Fabrication of 2D nanosheet through self assembly behavior of sulfamethoxypyridazine inclusion complexes with α- and ß-cyclodextrins.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;123:158-66, 2014 Apr 05.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 2D nanosheet was fabricated through the supramolecular self assembly of sulfamethoxypyridazine (SMP) and ß-cyclodextrin (ß-CD) inclusion complexes. HRTEM image exhibited 2D nanosheet morphology with a length of 1200mm and the sheet thickness of 60mm. It is noted that the nanosheet did not form a single layer aggregation but a bulk aggregation of SMP/ß-CD inclusion complex. The formation of this multilayer 2D nanosheet based on the self assembly of SMP/ß-CD inclusion complexes is proposed by the topological transformation as well as molecular modeling calculations. But, nanorods are formed in SMP/α-CD inclusion complex indicated that the nature of the CD determined the shape of the self assembled supramolecular architecture. The formation of nanomaterial was characterized by using FT-IR, DSC, PXRD, (1)H NMR, absorption, fluorescence and lifetime measurements.
[Mh] Termos MeSH primário: Antibacterianos/química
Ciclodextrinas/química
Nanoestruturas/química
Sulfametoxipiridazina/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Espectroscopia de Ressonância Magnética
Modelos Moleculares
Nanoestruturas/ultraestrutura
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cyclodextrins); T034E4NS2Z (Sulfamethoxypyridazine)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140221
[Lr] Data última revisão:
140221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140108
[St] Status:MEDLINE


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[PMID]:23183348
[Au] Autor:Khaleel ND; Mahmoud WM; Hadad GM; Abdel-Salam RA; Kümmerer K
[Ad] Endereço:Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Leuphana University Lüneburg, C13, DE-21335 Lüneburg, Germany. drndahshan@yahoo.com
[Ti] Título:Photolysis of sulfamethoxypyridazine in various aqueous media: aerobic biodegradation and identification of photoproducts by LC-UV-MS/MS.
[So] Source:J Hazard Mater;244-245:654-61, 2013 Jan 15.
[Is] ISSN:1873-3336
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sulfonamides are one of the most frequently used antibiotics worldwide. Therefore, mitigation processes such as abiotic or biotic degradation are of interest. Photodegradation and biodegradation are the potentially significant removal mechanisms for pharmaceuticals in aquatic environments. The photolysis of sulfamethoxypyridazine (SMP) using a medium pressure Hg-lamp was evaluated in three different media: Millipore water pH 6.1 (MW), effluent from sewage treatment plant pH 7.6 (STP), and buffered demineralized water pH 7.4 (BDW). Identification of transformation products (TPs) was performed by LC-UV-MS/MS. The biodegradation of SMP using two tests from the OECD series was studied: Closed Bottle test (OECD 301 D), and Manometric Respirometry test (OECD 301 F). In biodegradation tests, it was found that SMP was not readily biodegradable so it may pose a risk to the environment. The results showed that SMP was removed completely within 128 min of irradiation in the three media, and the degradation rate was different for each investigated type of water. However, dissolved organic carbon (DOC) was not removed in BDW and only little DOC removal was observed in MW and STP, thus indicating the formation of TPs. Analysis by LC-UV-MS/MS revealed new TPs formed. The hydroxylation of SMP represents the main photodegradation pathway.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Antibacterianos/efeitos da radiação
Sulfametoxipiridazina/metabolismo
Sulfametoxipiridazina/efeitos da radiação
Poluentes Químicos da Água/metabolismo
Poluentes Químicos da Água/efeitos da radiação
[Mh] Termos MeSH secundário: Aerobiose
Biodegradação Ambiental
Cromatografia Líquida de Alta Pressão/métodos
Oxigênio/metabolismo
Fotólise
Esgotos/microbiologia
Espectrometria de Massas em Tandem/métodos
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Sewage); 0 (Water Pollutants, Chemical); S88TT14065 (Oxygen); T034E4NS2Z (Sulfamethoxypyridazine)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121128
[St] Status:MEDLINE


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[PMID]:21351294
[Au] Autor:Jia A; Hu J; Wu X; Peng H; Wu S; Dong Z
[Ad] Endereço:Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, China.
[Ti] Título:Occurrence and source apportionment of sulfonamides and their metabolites in Liaodong Bay and the adjacent Liao River basin, North China.
[So] Source:Environ Toxicol Chem;30(6):1252-60, 2011 Jun.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The presence of antibiotics in the environment is of great concern because of their potential for resistance selection among pathogens. In the present study we investigated the occurrence of 19 sulfonamides, five N-acetylated sulfonamide metabolites, and trimethoprim in the Liao River basin and adjacent Liaodong Bay, China, as well as 10 human/agricultural source samples. Within the 35 river samples, 12 sulfonamides, four acetylated sulfonamides, and trimethoprim were detected, with the dominant being sulfamethoxazole (66.6 ng/L), N-acetylsulfamethoxazole (63.1 ng/L), trimethoprim (29.0 ng/L), sulfadiazine (14.0 ng/L), and sulfamonomethoxine (8.4 ng/L); within the 36 marine samples, 10 chemicals were detected, with the main contributions from sulfamethoxazole (25.2 ng/L) and N-acetylsulfamethoxazole (28.6 ng/L). Sulfamethoxazole (25.9%), N-acetylsulfamethoxazole (46.6%), trimethoprim (22.9%), and sulfapyridine (1.4%) were the main chemicals from human sources, while sulfamonomethoxine, sulfamethazine, sulfaquinoxaline, sulfaguanidine, sulfadiazine, sulfanilamide, and sulfamethoxypyridazine were dominant in the animal husbandry sources, specifically, swine and poultry farms, and sulfamethoxazole (91%) was dominant in the mariculture source. A principal component analysis with multiple linear regression was performed to evaluate the source apportionment of total sulfonamides in Liaodong Bay. It was found that animal husbandry contributed 15.2% of total sulfonamides, while human sources contributed 28.5%, and combined human and mariculture sources contributed 56.3%. In addition, the mariculture contribution was 24.1% of total sulfonamides into the sea based on mass flux estimation. The present study is the first report that the environmental levels of sulfonamide metabolites were comparable to the corresponding parents; therefore, we should pay attention to their environmental occurrence. Source apportionment showed human discharge (60.7%) significantly contributed to these antibiotics in Liaodong Bay, which provides important information for environmental management.
[Mh] Termos MeSH primário: Antibacterianos/análise
Rios/química
Sulfonamidas/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Agricultura
Aquicultura
China
Monitoramento Ambiental
Seres Humanos
Modelos Lineares
Análise de Componente Principal
Água do Mar/química
Espectrometria de Massas por Ionização por Electrospray
Sulfametazina/análise
Sulfametoxazol/análise
Sulfametoxipiridazina/análise
Sulfamonometoxina/análise
Sulfapiridina/análise
Sulfaquinoxalina/análise
Espectrometria de Massas em Tandem
Trimetoprima/análise
Poluição Química da Água/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Sulfonamides); 0 (Water Pollutants, Chemical); 48U51W007F (Sulfamethazine); AN164J8Y0X (Trimethoprim); JE42381TNV (Sulfamethoxazole); T034E4NS2Z (Sulfamethoxypyridazine); U700P169W2 (Sulfamonomethoxine); WNW8115TM9 (Sulfaquinoxaline); Y5V2N1KE8U (Sulfapyridine)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110226
[St] Status:MEDLINE
[do] DOI:10.1002/etc.508


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[PMID]:20391769
[Au] Autor:Tafintseva IIu; Zherdev AV; Eremin SA; Dzantiev BB
[Ti] Título:[Enzyme immunoassay for determination of sulfamethoxypyridazine in honey].
[So] Source:Prikl Biokhim Mikrobiol;46(2):232-6, 2010 Mar-Apr.
[Is] ISSN:0555-1099
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:An enzyme immunoassay technique for the detection of sulfamethoxypyridazine in honey, developed using rabbit polyclonal antibodies raised against N-sulfonyl-4-aminobutyric acid, which contains a structural group characteristic of sulfonamides, is proposed. Under the optimized conditions, the sulfamethoxypyridazine detection limit was 0.05 ng/ml, with the entire analysis procedure taking 2 h. In total, 24 honey samples were tested using the protocol based on tenfold dilutions of samples without their preliminary treatment.
[Mh] Termos MeSH primário: Mel/análise
Técnicas Imunoenzimáticas
Sulfametoxipiridazina/análise
[Mh] Termos MeSH secundário: Animais
Anticorpos
Coelhos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:ENGLISH ABSTRACT; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies); T034E4NS2Z (Sulfamethoxypyridazine)
[Em] Mês de entrada:1006
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100416
[St] Status:MEDLINE


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[PMID]:20175541
[Au] Autor:Sakharov IY; Berlina AN; Zherdev AV; Dzantiev BB
[Ad] Endereço:Chemical Enzymology Department, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory, Moscow, Russia. sakharovivan@gmail.com
[Ti] Título:Advantages of soybean peroxidase over horseradish peroxidase as the enzyme label in chemiluminescent enzyme-linked immunosorbent assay of sulfamethoxypyridazine.
[So] Source:J Agric Food Chem;58(6):3284-9, 2010 Mar 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An indirect competitive chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) of sulfamethoxypyridazine (SMP) was developed. The conjugates of streptavidin with cationic horseradish peroxidase (HRP) and anionic soybean peroxidase (SbP) were used in CL-ELISA for the detection of biotinylated anti-SMP antibodies. For streptavidin-HRP conjugate-catalyzed chemiluminescence measured 20 s after the initiation of the enhanced chemiluminescence reaction (ECR), the limit of detection (IC(10)), the IC(50) value, and the working range in CL-ELISA of SMP are 0.3, 12.4, and 1.2-85.0 ng/mL, respectively. An increase in the time interval between the ECR initiation and the luminescence measurement results in the loss in the quality of analytical measurements because of the time-dependent quenching of chemiluminescence typical of the HRP-catalyzed ECR. In the case of SbP-based CL-ELISA of SMP, the limit of detection, the IC(50) value, and the working range (0.025, 0.17, and 0.045-0.63 ng/mL, respectively) are better than those for HRP-based CL-ELISA. Furthermore, the analytical parameters of SbP-based CL-ELISA remain unchanged during a long period of time (for at least 30 min). The recovery values from four spiked milk samples with different concentrations of SMP in SbP-based CL-ELISA vary from 70 to 130%.
[Mh] Termos MeSH primário: Ensaio de Imunoadsorção Enzimática/métodos
Peroxidase do Rábano Silvestre/química
Medições Luminescentes/instrumentação
Peroxidase/química
Feijão de Soja/enzimologia
Sulfametoxipiridazina/análise
[Mh] Termos MeSH secundário: Ensaio de Imunoadsorção Enzimática/instrumentação
Medições Luminescentes/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 1.11.1.- (Horseradish Peroxidase); EC 1.11.1.7 (Peroxidase); T034E4NS2Z (Sulfamethoxypyridazine)
[Em] Mês de entrada:1007
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100224
[St] Status:MEDLINE
[do] DOI:10.1021/jf904338f


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[PMID]:18161327
[Au] Autor:Wu Y; Zhao L; Liu Y; Jiang Y; Liu X; Shen J
[Ad] Endereço:Quality Control and Inspection Center for Domestic Animal Products, Ministry of Agriculture, Beijing 100026, China. wupaddyfield@tom.com
[Ti] Título:[Simultaneous determination of nine sulfonamide residues in milk using solid phase extraction and high performance liquid chromatography].
[So] Source:Se Pu;25(5):728-31, 2007 Sep.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A simple, rapid, sensitive and reliable high performance liquid chromatographic method for the simultaneous determination of nine sulfonamides (SAs) (sulfadiazine, sulfathiazole, sulfamethazine, sulfamethoxypyridazine, sufamonomethoxine, sulfachloropyridazine, sulfamethoxazole, sulfadimethoxine and sulfaquinoxaline) in milk was developed. The method includes the shaking of the milk with phosphate buffer, centrifugation, and cleaning up on a C18 solid-phase extraction cartridge. The C18 cartridge was washed with water, and the SAs were eluted with methanol. After the evaporation, the residue was dissolved in ethyl acetate, and cleaned up on an amino solid-phase extraction column. Analytical separation was performed on an Inertsil ODS-3 column with photodiode-array detection at 270 nm under the gradient condition. The mean recoveries of SAs at the spiked levels of 10, 20, 40 microg/L were between 72.1% and 88.3%. The relative standard deviations were between 2.3% and 5.0%. The detection limits were 1.7 - 2.8 microg/L, and the quantification limits wer 5.7 - 9.2 microg/L.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Leite/química
Extração em Fase Sólida/métodos
Sulfonamidas/química
[Mh] Termos MeSH secundário: Animais
Bovinos
Reprodutibilidade dos Testes
Sulfadimetoxina/análise
Sulfadimetoxina/química
Sulfametazina/análise
Sulfametazina/química
Sulfametoxipiridazina/análise
Sulfametoxipiridazina/química
Sulfatiazóis/análise
Sulfatiazóis/química
Sulfonamidas/análise
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfathiazoles); 0 (Sulfonamides); 30CPC5LDEX (Sulfadimethoxine); 48U51W007F (Sulfamethazine); T034E4NS2Z (Sulfamethoxypyridazine); Y7FKS2XWQH (sulfathiazole)
[Em] Mês de entrada:1006
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071229
[St] Status:MEDLINE



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