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  1 / 93 MEDLINE  
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[PMID]:27164927
[Au] Autor:Zhang Q; Zhang D; Liu KY; Liu YH; Sheng J; Jin ZX; Wang SF; Bo QL; Wang JJ; Yin HF
[Ad] Endereço:1 Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
[Ti] Título:Perinatal sulfamonomethoxine exposure influences physiological and behavioral responses and the brain mTOR pathway in mouse offspring.
[So] Source:Hum Exp Toxicol;36(3):256-275, 2017 Mar.
[Is] ISSN:1477-0903
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sulfamonomethoxine (SMM) is widely used in the veterinary field in China. Although some clinical surveys have revealed that sulfonamide antibiotics cause adverse nervous system symptoms, the related mechanisms of maternal SMM exposure on the neurobehavioral development of offspring remain unclear. Here, we investigated the effects of perinatal SMM exposure on the physiological and behavioral responses of pubertal offspring mice and the underlying mechanisms. We randomly allocated pregnant mice into the groups treated with SMM at different doses and the saline-treated groups. Maternal mice were orally administered SMM daily from gestational day 1 to postpartum day 21. On postnatal day (PND) 22, the parameters of growth, endocrine hormones, and brain amino acid composition were assessed, as well as the brain transcript levels of key genes involved in the mammalian target of rapamycin (mTOR) signaling pathway. From PND 50 to 55, a battery of behavioral tests relevant to anxiety and memory were then administered. Analysis of the results indicated that the pups, particularly the pubertal female offspring, showed anxiety-like behavior. Moreover, the pubertal offspring showed cognitive impairments and fat accumulation. Furthermore, the relative mRNA expression of genes involved in the mTOR signaling pathway in females on PND 22 was elevated, whereas the expression of N-methyl-d-aspartate receptor 2B (NR B) was reduced. Together, the results showed that perinatal SMM exposure perturbs neuroendocrine functions, and further alters gene expression in the mTOR pathway and NR B gene expression early in life, which may contribute to brain dysfunction in pubertal life.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal
Sulfamonometoxina/toxicidade
Serina-Treonina Quinases TOR/metabolismo
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Encéfalo/metabolismo
Relação Dose-Resposta a Droga
Feminino
Hormônios/sangue
Masculino
Camundongos
Camundongos Endogâmicos ICR
Gravidez
RNA Mensageiro/genética
Serina-Treonina Quinases TOR/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones); 0 (RNA, Messenger); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.1 (mTOR protein, mouse); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE
[do] DOI:10.1177/0960327116646839


  2 / 93 MEDLINE  
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[PMID]:27173165
[Au] Autor:Zhang Q; Zhang D; Ye K; Liu K; Sheng J; Liu Y; Hu C; Ruan L; Li L; Tao F
[Ad] Endereço:Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, People's Republic of China.
[Ti] Título:Physiological and behavioral responses in offspring mice following maternal exposure to sulfamonomethoxine during pregnancy.
[So] Source:Neurosci Lett;624:8-16, 2016 Jun 15.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Sulfamonomethoxine (SMM), a veterinary antibiotic, is widely used in China. However, the impacts of maternal SMM exposure on neurobehavioral development in early life remain little known. In this study, we investigated the effects of maternal SMM exposure during pregnancy on behavioral and physiological responses in offspring mice. Pregnant mice were randomly divided into three SMM-treated groups, namely low-(10mg/kg/day), medium-(50mg/kg/day), and high-dose (200mg/kg/day), and a control group. The pregnant mice in the SMM-treated groups received SMM by gavage daily from gestational day 1-18, whereas those in the control received normal saline. On postnatal day (PND) 50, spatial memory was assessed using the Morris water maze test, and anxiety was measured using the elevated plus-maze and open field tests. The results showed significantly increased blood glucose in pups whose mothers received a high SMM dose. In addition, maternal SMM exposure increased anxiety-related activities among the offspring; spatial learning and memory were impaired more severely in the male offspring. The contents of tetrahydrobiopterin (BH4) and brain-derived neurotrophic factors (BDNF) on PND 22 were significantly reduced in the male offspring of the high-dose group compared with the controls. These findings indicate that SMM may be identified as a risk factor for cognitive and behavioral development on the basis of gender and that it may be associated with diminished BH4 and BDNF levels early in life.
[Mh] Termos MeSH primário: Anti-Infecciosos/toxicidade
Exposição Materna
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Efeitos Tardios da Exposição Pré-Natal/psicologia
Sulfamonometoxina/toxicidade
[Mh] Termos MeSH secundário: Animais
Ansiedade/induzido quimicamente
Comportamento Animal/efeitos dos fármacos
Glicemia
Peso Corporal/efeitos dos fármacos
Fator Neurotrófico Derivado do Encéfalo/sangue
Feminino
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos ICR
Gravidez
Efeitos Tardios da Exposição Pré-Natal/sangue
Serotonina/sangue
Tiroxina/sangue
Tri-Iodotironina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Blood Glucose); 0 (Brain-Derived Neurotrophic Factor); 06LU7C9H1V (Triiodothyronine); 333DO1RDJY (Serotonin); Q51BO43MG4 (Thyroxine); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE


  3 / 93 MEDLINE  
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[PMID]:26952272
[Au] Autor:Lin H; Jin D; Freitag TE; Sun W; Yu Q; Fu J; Ma J
[Ad] Endereço:The Institute of Environmental Resource and Soil Fertilizers, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, PR China.
[Ti] Título:A compositional shift in the soil microbiome induced by tetracycline, sulfamonomethoxine and ciprofloxacin entering a plant-soil system.
[So] Source:Environ Pollut;212:440-448, 2016 May.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antibiotics entering the soil likely disturb the complex regulatory network of the soil microbiome, which is closely associated with soil quality and ecological function. This study investigated the effects of tetracycline (TC), sulfamonomethoxine (SMM), ciprofloxacin (CIP) and their combination (AM) on the bacterial community in a soil-microbe-plant system and identified the main bacterial responders. Antibiotic effects on the soil microbiome depended on antibiotic type and exposure time. TC resulted in an acute but more rapidly declining effect on soil microbiome while CIP and SMM led to a delayed antibiotic effect. The soil exposed to AM presented a highly similar bacterial structure to that exposed to TC rather than to SMM and CIP. TC, SMM and CIP had their own predominantly impacted taxonomic groups that include both resistance and sensitive bacteria. The antibiotic sensitive responders predominantly distributed within the phylum Proteobacteria. The potential bacteria resistant to each antibiotic exhibited phyla preference to some extent, particularly those resistant to TC. CIP and SMM resistance in soil was increased with exposure time while TC resistance gave the opposite result. Overall, the work extended the understanding of antibiotic effects on soil microbiome after introduced into the soil during greenhouse vegetable cultivation.
[Mh] Termos MeSH primário: Ciprofloxacino/farmacologia
Microbiota/efeitos dos fármacos
Microbiologia do Solo
Poluentes do Solo/farmacologia
Sulfamonometoxina/farmacologia
Tetraciclina/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Plantas/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Soil Pollutants); 5E8K9I0O4U (Ciprofloxacin); F8VB5M810T (Tetracycline); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE


  4 / 93 MEDLINE  
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[PMID]:25704680
[Au] Autor:Bilandzic N; Bozic D; Kolanovic BS; Varenina I; Cvetnic L; Cvetnic Z
[Ad] Endereço:Department of Veterinary Public Health, Laboratory for Residue Control, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia. Electronic address: bilandzic@veinst.hr.
[Ti] Título:Distribution of sulfamonomethoxine and trimethoprim in egg yolk and white.
[So] Source:Food Chem;178:32-7, 2015 Jul 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The distribution of sulfamonomethoxine (SMM) and trimethoprim (TMP) in egg yolk and white was measured during and after administration of a SMM/TMP combination in laying hens in doses of 8 g l(-)(1) and 12 g l(-)(1) in drinking water for 7 days. The SMM concentration reached maximal levels on day 2 of the post-treatment period for both doses (µg kg(-)(1)): 5920 and 9453 in yolk; 4831 and 6050 in white, in doses 1 and 2, respectively. Significant differences in the SMM and TMP concentrations between yolk and white in post treatment period were found. SMM dropped below the LOD (1.9 µg kg(-1)) in yolk after day 16 and 19 for doses 1 and 2. TMP reached maximal levels on day 3 after drug administration for doses 1 and 2 (µg kg(-)(1)): 6521 and 7329 in yolk, 1370 and 1539 in white. TMP residues were measured above LOD (0.3 µg kg(-)(1)) in yolk for both doses on day 37 post-treatment.
[Mh] Termos MeSH primário: Gema de Ovo/química
Ovos/análise
Espectrometria de Massas/métodos
Sulfamonometoxina/química
Trimetoprima/química
[Mh] Termos MeSH secundário: Animais
Resíduos de Drogas/análise
Sulfamonometoxina/análise
Trimetoprima/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
AN164J8Y0X (Trimethoprim); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150223
[Lr] Data última revisão:
150223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150224
[St] Status:MEDLINE


  5 / 93 MEDLINE  
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[PMID]:25311913
[Au] Autor:Elbadawy M; Sakiyama T; Abohatab R; Sasaki K; Shimoda M
[Ad] Endereço:Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
[Ti] Título:Oral pharmacokinetics of the acidic drugs, diclofenac and sulfamonomethoxine in male Shiba goats.
[So] Source:J Vet Med Sci;77(1):21-6, 2015 Jan.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In the present study, we examined the oral pharmacokinetics of the acidic drugs, diclofenac (DF) and sulfamonomethoxine (SMM), which have different physicochemical properties, in Shiba goats. DF and SMM were intravenously and orally administered to 5 male goats using a crossover design. The T(max) of DF and SMM were reached 1.5 and 5.6 hr after they have been orally administered, respectively, and this was followed by their slow elimination. The elimination of both drugs was markedly faster after being intravenously rather than orally administered, which indicated flip-flop phenomena after the oral administration. The mean absorption times (MATs) of DF and SMM were 6 and 15 hr, respectively. This slow absorption may have been due to slow gastric emptying in goats. The large difference observed in MATs between DF and SMM may have been because DF, which is more lipophilic than SMM, was partly absorbed from the forestomach. Therefore, these results suggest that the absorption of highly lipophilic drugs from the forestomach may be markedly high in Shiba goats. In case of drugs whose elimination is quite fast, their efficacies may appear from the early stage after oral administration even in ruminants, because elimination rate is the determinant factor of T(max) in flip-flop phenomena. Such drugs may be used orally even in ruminants.
[Mh] Termos MeSH primário: Diclofenaco/farmacocinética
Cabras/metabolismo
Sulfamonometoxina/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Infecciosos/administração & dosagem
Anti-Infecciosos/sangue
Anti-Infecciosos/farmacocinética
Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/sangue
Anti-Inflamatórios não Esteroides/farmacocinética
Estudos Cross-Over
Diclofenaco/administração & dosagem
Diclofenaco/sangue
Cabras/sangue
Masculino
Rúmen
Sulfamonometoxina/administração & dosagem
Sulfamonometoxina/sangue
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents, Non-Steroidal); 144O8QL0L1 (Diclofenac); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141015
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.14-0261


  6 / 93 MEDLINE  
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[PMID]:25461547
[Au] Autor:Huang DJ; Hou JH; Kuo TF; Lai HT
[Ad] Endereço:Department of Environmental Resources Management, Chia Nan University of Pharmacy & Science, No. 60, Sec. 1, Erren Road, Tainan 71710, Taiwan.
[Ti] Título:Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms.
[So] Source:Environ Toxicol Pharmacol;38(3):874-80, 2014 Nov.
[Is] ISSN:1872-7077
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the acute and chronic toxicity of sulfamonomethoxine (SMM) to aquatic organisms to evaluate its impact at different trophic levels in the ecosystem. Regarding the growth inhibition of microalgae, SMM exhibited 72-h median effective concentration (EC50) values of 5.9mgL(-1) for freshwater Chlorella vulgaris and 9.7mgL(-1) for marine Isochrysis galbana. In a study on the cladocerans, SMM exhibited acute toxicity and 48-h median lethal concentrations of 48mgL(-1) for Daphnia magna and 283mgL(-1) for D. similis. An examination of chronic toxicity revealed that SMM inhibited the brook production of the cladocerans and exhibited 21-day EC50 values of 14.9mgL(-1) for D. magna and 41.9mgL(-1) for D. similis. This study investigated the potentially adverse effects of SMM on aquatic organisms and revealed that microalgae exhibited higher sensitivity to SMM than cladocerans did. The residue of SMM in water is recommended to be carefully evaluated to reduce ecological impacts after applied to cultured animals.
[Mh] Termos MeSH primário: Anti-Infecciosos/toxicidade
Organismos Aquáticos/efeitos dos fármacos
Sulfamonometoxina/toxicidade
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos/crescimento & desenvolvimento
Chlorella vulgaris/efeitos dos fármacos
Chlorella vulgaris/crescimento & desenvolvimento
Daphnia/efeitos dos fármacos
Daphnia/crescimento & desenvolvimento
Haptófitas/efeitos dos fármacos
Haptófitas/crescimento & desenvolvimento
Oryzias/classificação
Oryzias/crescimento & desenvolvimento
Testes de Toxicidade Aguda
Testes de Toxicidade Crônica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141203
[Lr] Data última revisão:
141203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  7 / 93 MEDLINE  
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[PMID]:24590603
[Au] Autor:Ma J; Lin H; Sun W; Wang Q; Yu Q; Zhao Y; Fu J
[Ad] Endereço:Institute of Environment Resource and Soil Fertilizer, Zhejiang Academy of Agriculture Science, Hangzhou, 310021, China.
[Ti] Título:Soil microbial systems respond differentially to tetracycline, sulfamonomethoxine, and ciprofloxacin entering soil under pot experimental conditions alone and in combination.
[So] Source:Environ Sci Pollut Res Int;21(12):7436-48, 2014 Jun.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study investigated soil microbial responses to the application of tetracycline (TC), sulfamonomethoxine (SMM), and ciprofloxacin (CIP) alone and in combination in a soil culture pot experiment conducted at Hangzhou, China. Multiple approaches were applied for a better and complete depiction. Among the three antibiotics, SMM has a lowest dissipation and shows a most dramatic inhibition on microbial community and metabolism diversity. The combined application (AM) of SMM, CIP, and TC improved the dissipation of each antibiotic; similarly, SMM- and CIP-resistant bacteria showed larger populations in the AM than all single applications. Soils accumulated a large content of NO3-N at day 20 after multi-antibiotics perturbation. All antibiotics stimulated soil basal respirations and inhibited soil metabolism diversity, whereas the interruption exerted by SMM and AM lasted for a longer time. Six nitrogen-cycling genes including chiA, amoA, nifH, nirK, nirS, and narG were quantified and found to decrease owing to both single- and multi-antibiotics perturbation. Overall, AM was most interruptive for soils, followed by SMM perturbation, while other antibiotics could be less interruptive. These results provide systematic insights into how soil microbial systems would shift under each single- or multi-antibiotics perturbation.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Bactérias/efeitos dos fármacos
Ciprofloxacino/metabolismo
Microbiologia do Solo
Sulfamonometoxina/metabolismo
Tetraciclina/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bactérias/genética
China
Cromatografia Líquida de Alta Pressão
Ciprofloxacino/farmacologia
Farmacorresistência Bacteriana/genética
Ciclo do Nitrogênio
Reação em Cadeia da Polimerase em Tempo Real
Sulfamonometoxina/farmacologia
Espectrometria de Massas em Tandem
Tetraciclina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin); F8VB5M810T (Tetracycline); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140305
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-014-2685-2


  8 / 93 MEDLINE  
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[PMID]:24577641
[Au] Autor:Chang ZQ; Li ZX; Li JB; Wang YZ; Li J
[Ad] Endereço:Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, No. 106 Nanjing Road, Qingdao, 266071, People's Republic of China, changzq@ysfri.ac.cn.
[Ti] Título:Pharmacokinetics of sulfamonomethoxine in tongue sole (Cynoglossus semilaevis) after intravenous and oral administration.
[So] Source:Fish Physiol Biochem;40(4):1275-9, 2014 Aug.
[Is] ISSN:1573-5168
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The pharmacokinetic profiles of sulfamonomethoxine (SMM) were investigated in flatfish tongue soles in the present study. After a single injection of SMM (40 mg/kg BW) to caudal vein of tongue sole at 20 °C, plasma drug concentration versus time data were best fitted to a three-compartment model, characterized with 0.2, 5.7, and 80.4 h for the half-life (t 1/2) of fast distribution, slow distribution, and elimination, respectively. The apparent volume of distribution was 0.1 L/kg, and the body clearance was 0.03 L/h/kg. After oral administration of SMM (200 mg/kg BW) to tongue soles at 20 °C, plasma drug concentrations were best fitted to a two-compartment model, of which the mean half-life of absorption (t 1/2ka) and elimination (t 1/2ß ) were 1.7 and 95.7 h, respectively. The maximal absorption concentration (C max) was estimated as 58 mg/L at 2.5 h, and the mean systemic bioavailability (F) was 39.5 % in tongue soles after oral administration.
[Mh] Termos MeSH primário: Linguados/metabolismo
Sulfamonometoxina/farmacocinética
[Mh] Termos MeSH secundário: Administração Intravenosa
Administração Oral
Animais
Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Relação Dose-Resposta a Droga
Meia-Vida
Cinética
Modelos Estatísticos
Sulfamonometoxina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140301
[St] Status:MEDLINE
[do] DOI:10.1007/s10695-014-9922-y


  9 / 93 MEDLINE  
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[PMID]:24573579
[Au] Autor:Yan H; Gao M; Yang C; Qiu M
[Ad] Endereço:Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding, 071002, China, yanhy@hbu.edu.cn.
[Ti] Título:Ionic liquid-modified magnetic polymeric microspheres as dispersive solid phase extraction adsorbent: a separation strategy applied to the screening of sulfamonomethoxine and sulfachloropyrazine from urine.
[So] Source:Anal Bioanal Chem;406(11):2669-77, 2014 Apr.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Ionic liquid-modified magnetic polymeric microspheres (ILMPM) were prepared based on Fe3O4 magnetic nanoparticles (MNPs) and ionic liquids (ILs) incorporated into a polymer. The composites were characterized using scanning electron microscopy, Fourier transform infrared analysis, thermogravimetric analysis, X-ray diffraction, and vibrating magnetometer, which indicated that ILMPM had a regularly spherical shape and strong magnetic property. The obtained ILMPM were successfully applied as a special adsorbent of magnetic dispersive solid phase extraction (MDSPE) for the rapid extraction and isolation of sulfamonomethoxine sodium and sulfachloropyrazine sodium in urine. The factors that affected extraction efficiency, such as adsorption conditions, desorption conditions, washing and elution solvents, and pH of the sample solution, were optimized. Under the optimum condition, good linearity in the range of 0.005-2.0 µg g(-1) (r ≥ 0.9996) was obtained for the two sulfonamides (SAs); the average recoveries at three spiked levels ranged from 86.9 to 102.1 %, with relative standard deviations of ≤4.3 %. The presented ILMPM-MDSPE method combined the advantages of ILs, MNPs, and MDSPE and therefore could be potentially applied for rapid screening of SAs in urine.
[Mh] Termos MeSH primário: Polímeros/química
Extração em Fase Sólida/instrumentação
Sulfamonometoxina/isolamento & purificação
Sulfanilamidas/isolamento & purificação
[Mh] Termos MeSH secundário: Adsorção
Seres Humanos
Líquidos Iônicos/química
Fenômenos Magnéticos
Microesferas
Extração em Fase Sólida/métodos
Sulfamonometoxina/urina
Sulfanilamidas/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ionic Liquids); 0 (Polymers); 0 (Sulfanilamides); 96R84UZ2XA (sulfachlorpyrazine); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:160512
[Lr] Data última revisão:
160512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140228
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-014-7665-3


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[PMID]:24080579
[Au] Autor:Al-Mogren MM; Alaghaz AN; El-Gogary TM
[Ad] Endereço:Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
[Ti] Título:Spectral and quantum chemical studies on 1,3-bis(N(1)-4-amino-6-methoxypyrimidinebenzenesulfonamide-2,2,4,4-ethane-1,2-dithiol)-2,4-dichlorocyclodiphosph(V)azane and its erbium complex.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;118:481-7, 2014 Jan 24.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Novel 1,3-bis(N(1)-4-amino-6-methoxypyrimidine-benzenesulfonamide-2,2,4,4-ethane-1,2-dithiol)-2,4-dichlorocyclodiphosph(V)azane (L), was prepared and their coordinating behavior towards the lanthanide ion Er(III) was studied. The structures of the isolated products are proposed based on elemental analyses, IR, UV-VIS., (1)H NMR, (13)C NMR, (31)P NMR, SEM, XRD, mass spectra, effective magnetic susceptibility measurements and thermogravimetric analysis (TGA). Computational studies have been carried out at the DFT-B3LYP/6-31G(d) level of theory on the structural and spectroscopic properties of L and its binuclear Er(III) complex. Different tautomers of the ligand were optimized at the ab initio DFT level. Keto-form structure is about 17.7 kcal/mol more stable than the enol form (taking zpe correction into account). Simulated IR frequencies were scaled and compared with that experimentally measured. TD-DFT method was used to compute the UV-VIS spectra which compared by the measured electronic spectra.
[Mh] Termos MeSH primário: Complexos de Coordenação/química
Érbio/química
Compostos Organofosforados/química
Sulfamonometoxina/química
Sulfonamidas/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Modelos Moleculares
Espectrofotometria Infravermelho
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Organophosphorus Compounds); 0 (Sulfonamides); 77B218D3YE (Erbium); U700P169W2 (Sulfamonomethoxine)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:131111
[Lr] Data última revisão:
131111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131002
[St] Status:MEDLINE



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