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  1 / 92 MEDLINE  
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[PMID]:26959547
[Au] Autor:Abd El-Hay SS; Hashem H; Gouda AA
[Ti] Título:High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms.
[So] Source:Acta Pharm;66(1):109-18, 2016 Mar.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:A novel, simple and robust high-performance liquid chromatography (HPLC) method was developed and validated for simultaneous determination of xipamide (XIP), triamterene (TRI) and hydrochlorothiazide (HCT) in their bulk powders and dosage forms. Chromatographic separation was carried out in less than two minutes. The separation was performed on a RP C-18 stationary phase with an isocratic elution system consisting of 0.03 mol L(-1) orthophosphoric acid (pH 2.3) and acetonitrile (ACN) as the mobile phase in the ratio of 50:50, at 2.0 mL min(-1) flow rate at room temperature. Detection was performed at 220 nm. Validation was performed concerning system suitability, limits of detection and quantitation, accuracy, precision, linearity and robustness. Calibration curves were rectilinear over the range of 0.195-100 µg mL(-1) for all the drugs studied. Recovery values were 99.9, 99.6 and 99.0 % for XIP, TRI and HCT, respectively. The method was applied to simultaneous determination of the studied analytes in their pharmaceutical dosage forms.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Hidroclorotiazida/química
Pós/análise
Pós/química
Triantereno/química
Xipamida/química
[Mh] Termos MeSH secundário: Calibragem
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Powders); 0J48LPH2TH (Hydrochlorothiazide); 4S9EY0NUEC (Xipamide); WS821Z52LQ (Triamterene)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE


  2 / 92 MEDLINE  
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[PMID]:24117047
[Au] Autor:Ju M; Scott-Ward TS; Liu J; Khuituan P; Li H; Cai Z; Husbands SM; Sheppard DN
[Ad] Endereço:School of Physiology and Pharmacology, University of Bristol, Bristol, UK.
[Ti] Título:Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics.
[So] Source:Br J Pharmacol;171(1):265-78, 2014 Jan.
[Is] ISSN:1476-5381
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Loop diuretics are widely used to inhibit the Na(+), K(+), 2Cl(-) co-transporter, but they also inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. Here, we investigated the mechanism of CFTR inhibition by loop diuretics and explored the effects of chemical structure on channel blockade. EXPERIMENTAL APPROACH: Using the patch-clamp technique, we tested the effects of bumetanide, furosemide, piretanide and xipamide on recombinant wild-type human CFTR. KEY RESULTS: When added to the intracellular solution, loop diuretics inhibited CFTR Cl(-) currents with potency approaching that of glibenclamide, a widely used CFTR blocker with some structural similarity to loop diuretics. To begin to study the kinetics of channel blockade, we examined the time dependence of macroscopic current inhibition following a hyperpolarizing voltage step. Like glibenclamide, piretanide blockade of CFTR was time and voltage dependent. By contrast, furosemide blockade was voltage dependent, but time independent. Consistent with these data, furosemide blocked individual CFTR Cl(-) channels with 'very fast' speed and drug-induced blocking events overlapped brief channel closures, whereas piretanide inhibited individual channels with 'intermediate' speed and drug-induced blocking events were distinct from channel closures. CONCLUSIONS AND IMPLICATIONS: Structure-activity analysis of the loop diuretics suggests that the phenoxy group present in bumetanide and piretanide, but absent in furosemide and xipamide, might account for the different kinetics of channel block by locking loop diuretics within the intracellular vestibule of the CFTR pore. We conclude that loop diuretics are open-channel blockers of CFTR with distinct kinetics, affected by molecular dimensions and lipophilicity.
[Mh] Termos MeSH primário: Cloretos/metabolismo
Regulador de Condutância Transmembrana em Fibrose Cística/antagonistas & inibidores
Inibidores de Simportadores de Cloreto de Sódio e Potássio/farmacologia
[Mh] Termos MeSH secundário: Animais
Bumetanida/farmacologia
Cricetinae
Regulador de Condutância Transmembrana em Fibrose Cística/genética
Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo
Relação Dose-Resposta a Droga
Furosemida/farmacologia
Seres Humanos
Cinética
Potenciais da Membrana
Camundongos
Estrutura Molecular
Ratos
Inibidores de Simportadores de Cloreto de Sódio e Potássio/química
Relação Estrutura-Atividade
Sulfonamidas/farmacologia
Xipamida/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CFTR protein, human); 0 (Chlorides); 0 (Sodium Potassium Chloride Symporter Inhibitors); 0 (Sulfonamides); 0Y2S3XUQ5H (Bumetanide); 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator); 4S9EY0NUEC (Xipamide); 7LXU5N7ZO5 (Furosemide); DQ6KK6GV93 (piretanide)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:150422
[Lr] Data última revisão:
150422
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131015
[St] Status:MEDLINE
[do] DOI:10.1111/bph.12458


  3 / 92 MEDLINE  
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[PMID]:24091803
[Au] Autor:Walash MI; El-Enany N; Eid MI; Fathy ME
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516, Mansoura, Egypt.
[Ti] Título:Stability-Indicating Spectrofluorimetric Methods for the Determination of Metolazone and Xipamide in Their Tablets. Application to Content Uniformity Testing.
[So] Source:J Fluoresc;24(2):363-76, 2014 Mar.
[Is] ISSN:1573-4994
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A highly sensitive, simple and rapid stability-indicating spectrofluorimetric method was developed for the determination of metolazone (MET) and xipamide (XPM) in their tablets. The proposed method is based on the measurement of the native fluorescence of MET in methanol at 437 nm after excitation at 238 nm and XPM in alkaline methanolic solution at 400 nm after excitation at 255 nm. The fluorescence-concentration plots were rectilinear over the range of 2.0- 20.0 ng/mL for MET and 0.2- 2.0 µg/mL for XPM, with lower detection limits (LOD) of 0.35 ng/mL and 0.02 µg/mL and a lower quantification limit (LOQ) of 1.05 ng/mL and 0.07 µg/mL for MET and XPM, respectively. The method was successfully applied to the analysis of MET and XPM in their commercial tablets and the results were in good agreement with those obtained using the official and comparison methods, respectively. Furthermore, content uniformity testing of the studied pharmaceutical tablets was also conducted. The application of the proposed method was extended to stability studies of MET and XPM after exposure to different forced degradation conditions, such as acidic, alkaline, oxidative and photolytic degradation conditions, according to ICH Guidelines. Moreover, the method was utilized to investigate the kinetics of the alkaline, acidic and photolytic degradation of MET. The apparent first-order rate constants and half-life times were calculated. Proposals for the degradation pathways for both MET and XPM were postulated.
[Mh] Termos MeSH primário: Metolazona/análise
Espectrometria de Fluorescência/métodos
Comprimidos/química
Xipamida/análise
[Mh] Termos MeSH secundário: Estabilidade de Medicamentos
Cinética
Limite de Detecção
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Tablets); 4S9EY0NUEC (Xipamide); TZ7V40X7VX (Metolazone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131005
[St] Status:MEDLINE
[do] DOI:10.1007/s10895-013-1301-z


  4 / 92 MEDLINE  
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[PMID]:22771563
[Au] Autor:Al-Kady AS
[Ad] Endereço:Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt. ahsaelkady@yahoo.com
[Ti] Título:Selective and sensitive spectrophotometric method for the determination of trace amounts of zirconium in environmental and biological samples using 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;97:284-9, 2012 Nov.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple, selective and sensitive spectrophotometric method for the determination of trace amounts of Zr(IV) in aqueous samples was performed, based on complexation reaction between Zr(IV) and 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide (xipamide). The important analytical parameters and their effects on the reported system were investigated. Zr(IV) react with xipamide in the ratio 1:1 in the pH range 8 to form a complex with an absorption maximum 333 nm. The apparent stability constant (logß(n)) and the free energy change (ΔG) of formation of the complex was calculated using the results of mole ratio and continuous variation methods. Beer's law was obeyed in the concentration range 0.2-3.6 µg/mL. For more accurate analysis, Ringbom optimum concentration range was found from 0.3 to 3.5 µg/mL. The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. Taking a constant concentration of Zr(IV) and determining its concentration in the presence of large number of foreign ions tested the effect of foreign ions. The practical applicability of the elaborated method was examined using for determination of mentioned ion in water samples, biological, plant leaves and soil samples where excellent agreements between reported and obtained results were achieved. The relative standard deviation (n=6) were 0.195%. The precision and accuracy of the results were comparable via F and t test at the 95% confidence level.
[Mh] Termos MeSH primário: Benzamidas/química
Meio Ambiente
Folhas de Planta/química
Espectrofotometria/métodos
Água/química
Zircônio/análise
[Mh] Termos MeSH secundário: Absorção
Seres Humanos
Concentração de Íons de Hidrogênio
Indicadores e Reagentes
Íons
Modelos Químicos
Espectrofotometria Ultravioleta
Xipamida/química
Zircônio/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide); 0 (Benzamides); 0 (Indicators and Reagents); 0 (Ions); 059QF0KO0R (Water); 4S9EY0NUEC (Xipamide); C6V6S92N3C (Zirconium)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120710
[St] Status:MEDLINE


  5 / 92 MEDLINE  
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[PMID]:22197154
[Au] Autor:Maher HM; Youssef RM; El-Kimary EI; Hassan EM; Barary MA
[Ad] Endereço:Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El-Messalah, Alexandria 21521, Egypt. hadirrona@yahoo.com
[Ti] Título:Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination.
[So] Source:J Pharm Biomed Anal;61:78-85, 2012 Mar 05.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An efficient chromatographic method for the simultaneous determination of triamterene (TRI) and xipamide (XIP) in urine samples, based on high performance liquid chromatography with photodiode array detector (HPLC-DAD) has been developed. The HPLC separation was performed on a RP stainless-steel C-18 analytical column (250 mm × 4.6 mm, 5 µm) with a gradient elution system of 0.05 M phosphate buffer adjusted to pH 4.0 and methanol as the mobile phase. The method was used to determine the urinary excretion profile and to calculate different urinary pharmacokinetic parameters following oral dose of their combination compared with single oral doses of each drug and hence comparing their bioavailability. Quantitation was performed using chlorthalidone as internal standard. The calibration graphs of each drug were rectilinear in the range of 0.2-40 µg/mL urine for TRI and 0.2-15 µg/mL urine for XIP. An HPLC-DAD method was also successfully developed for the simultaneous determination of the investigated drugs in pharmaceutical preparations. The methods were validated in terms of linearity, accuracy, precision, selectivity, limits of detection and quantitation and other aspects of analytical validation.
[Mh] Termos MeSH primário: Triantereno/farmacocinética
Triantereno/urina
Xipamida/farmacocinética
Xipamida/urina
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Disponibilidade Biológica
Combinação de Medicamentos
Seres Humanos
Masculino
Triantereno/administração & dosagem
Xipamida/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 4S9EY0NUEC (Xipamide); WS821Z52LQ (Triamterene)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111227
[St] Status:MEDLINE
[do] DOI:10.1016/j.jpba.2011.11.032


  6 / 92 MEDLINE  
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[PMID]:20878892
[Au] Autor:Wagieh NE; Abbas SS; Abdelkawy M; Abdelrahman MM
[Ad] Endereço:Analytical Chemistry Department, Beni-Suef University, Egypt.
[Ti] Título:Spectrophotometric and spectrodensitometric determination of triamterene and xipamide in pure form and in pharmaceutical formulation.
[So] Source:Drug Test Anal;2(3):113-21, 2010 Mar.
[Is] ISSN:1942-7611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sensitive and validated UV-spectrophotometric, chemometric and TLC-densitometric methods were developed for determination of triamterene (TRM) and xipamide (XIP) in their binary mixture, formulated for use as a diuretic, without previous separation. Method A is the isoabsorptive point spectrophotometry, in which TRM concentration alone can be determined at its λ(max) while XIP concentration can be determined by measuring total concentration of TRM and XIP at their isoabsorptive point followed by subtraction. Method B is the ratio subtraction spectrophotometry, where XIP can be determined by dividing the spectrum of the mixture by the spectrum of TRM (as a divisor) followed by subtracting the constant absorbance value of the plateau region, then finally multiplying the produced spectrum by the spectrum of the divisor, while TRM concentration can be determined at its λ(max). Method C is a chemometric-assisted spectrophotometry where classical least squares, principal component regression, and partial least squares were applied. Method D is a TLC-densitometry; this method depends on quantitative densitometric separation of thin layer chromatogram of TRM and XIP using silica gel plates at 254 nm. The proposed methods were successfully applied for the analysis of TRM and XIP in their pharmaceutical formulation and the results were statistically compared with the established HPLC method.
[Mh] Termos MeSH primário: Preparações Farmacêuticas/química
Triantereno/análise
Xipamida/análise
[Mh] Termos MeSH secundário: Calibragem
Cromatografia em Camada Delgada/instrumentação
Cromatografia em Camada Delgada/métodos
Contaminação de Medicamentos
Estrutura Molecular
Reprodutibilidade dos Testes
Espectrofotometria Ultravioleta/instrumentação
Espectrofotometria Ultravioleta/métodos
Triantereno/química
Xipamida/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 4S9EY0NUEC (Xipamide); WS821Z52LQ (Triamterene)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:160511
[Lr] Data última revisão:
160511
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100930
[St] Status:MEDLINE
[do] DOI:10.1002/dta.92


  7 / 92 MEDLINE  
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[PMID]:15727159
[Au] Autor:Knauf H; Mutschler E
[Ad] Endereço:Medizinische Klinik I, St Bernward-Krankenhaus, Hildesheim, Frankfurt/Main.
[Ti] Título:[Mechanism of action of xipamide and its classification as a "low ceiling diuretic". Pharmacodynamic-pharmacokinetic studies in healthy volunteers and in kidney and liver patients].
[Ti] Título:Zur Wirkungsweise von Xipamid und seiner Klassifizierung als "Low-ceiling- Diuretikum". Pharmakodynamische und pharmakokinetische Untersuchungen an gesunden Probanden sowie bei Nieren- und Leberkranken..
[So] Source:Arzneimittelforschung;55(1):1-14, 2005.
[Is] ISSN:0004-4172
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Xipamide (CAS 14293-44-8) shows structural features comparable with the thiazide- as well as the class of loop diuretics. According to earlier findings this diuretic, in contrast to the thiazides, should not decrease the glomerular filtration rate (GFR) and be effective even in patients with advanced renal failure. Therefore recently the question, which class of diuretics xipamide should be related to, has been increasingly discussed. In order to solve this issue, the diuretic effect of xipamide was assessed in healthy volunteers once without and once under strict water and salt restriction. Additionally, changes in GFR were monitored by means of measurement of the creatinine clearance. Kinetic parameters were determined in plasma and urine; further, in patients with liver cirrhosis, renal elimination kinetics of the diuretic were correlated with the concentration of direct plasma bilirubin, as a marker of cholestasis, at the beginning of a treatment with xipamide, 40 mg qd. The investigations proved that xipamide, like a typical thiazide diuretic, gives rise to a temporary decrease in GFR of about 30 %, provided the renin-angiotensin-aldosterone system of the volunteer is activated by previous salt and water restriction. Xipamide leads to an increase of K+ and Mg2+ excretion, but to a decrease of Ca2+ excretion in urine, a charactaristical feature of the thiazide-like diuretics. The correlation between Na+ excretion and drug excreted in urine over time showed a functional graph that is characteristic for a "low ceiling" thiazide diuretic. In patients with renal failure FE(Na) was increased when related to the GFR-adjusted drug excretion rate, whereas it was diminished in conditions with decreased effective circulating volume like in liver cirrhosis with ascites. It could be shown that the elimination kinetics of xipamide are determined by renal drug clearance, which proportionally decreases with GFR. In patients with liver failure, a decrease of non-renal drug clearance went along with an increase in urinary drug excretion. The amount of drug excreted in urine (Ae) proportionally increased with the concentration of the patients' direct plasma bilirubin. Thus, from a pharmacological as well as clinical point of view xipamide acts like a thiazide diuretic. As could be shown for other thiazides some time ago, xipamide is effective not only in patients with cardiovascular diseases, but also in those with advanced renal failure.
[Mh] Termos MeSH primário: Diuréticos/farmacologia
Diuréticos/farmacocinética
Nefropatias/metabolismo
Hepatopatias/metabolismo
Xipamida/farmacologia
Xipamida/farmacocinética
[Mh] Termos MeSH secundário: Bilirrubina/metabolismo
Colestase/diagnóstico
Creatinina/sangue
Dieta Hipossódica
Diurese/efeitos dos fármacos
Furosemida/farmacologia
Taxa de Filtração Glomerular
Seres Humanos
Testes de Função Renal
Cirrose Hepática/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics); 4S9EY0NUEC (Xipamide); 7LXU5N7ZO5 (Furosemide); AYI8EX34EU (Creatinine); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:0503
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050225
[St] Status:MEDLINE


  8 / 92 MEDLINE  
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[PMID]:15384135
[Au] Autor:Kim Y; Han K; Paeng KJ
[Ti] Título:Determination of Xipamide metabolite in human urine by high-performance liquid chromatography/diode-array detection, high-performance liquid chromatography/electrospray ionization mass spectrometry and gas chromatography/mass spectrometry.
[So] Source:Rapid Commun Mass Spectrom;18(20):2505-12, 2004.
[Is] ISSN:0951-4198
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Doping nos Esportes/prevenção & controle
Cromatografia Gasosa-Espectrometria de Massas/métodos
Espectrometria de Massas por Ionização por Electrospray/métodos
Detecção do Abuso de Substâncias/métodos
Urinálise/métodos
Xipamida/urina
[Mh] Termos MeSH secundário: Diuréticos/urina
Doping nos Esportes/métodos
Seres Humanos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Diuretics); 4S9EY0NUEC (Xipamide)
[Em] Mês de entrada:0411
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040924
[St] Status:MEDLINE


  9 / 92 MEDLINE  
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[PMID]:15023259
[Au] Autor:Akesolo U; Maguregui MI; González L; Jiménez RM; Alonso RM
[Ad] Endereço:Departamento de Química Analítica, Facultad de Ciencias, Universidad del País Vasco, Apdo. 644, 48080 Bilbao, Spain. qapalror@lg.ehu.es
[Ti] Título:Experimental design optimization of a capillary zone electrophoresis method for the screening of several diuretics and ACE inhibitors.
[So] Source:J Chromatogr Sci;42(2):74-9, 2004 Feb.
[Is] ISSN:0021-9665
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Experimental design methodologies are applied to the development of a capillary zone electrophoretic method for the separation of the angiotensin-converting enzyme inhibitor enalapril and its derivative enalaprilat and the diuretics xipamide and hydrochlorothiazide. The effects of pH, buffer concentration, proportion of boric acid in the mixed boric acid-potassium dihydrogen phosphate background electrolyte, temperature, applied voltage, and percentage of organic modifier are studied. Critical factors are identified in a screening design (a 2(6-2) fractional factorial design), and afterwards, optimal conditions for the separation are reached by means of an optimization design (a 2(2) + 2 x 2 + k central composite design). The studied response is the resolution between peaks. The four studied compounds can be separated in less than 3.5 min using an electrolyte of 20mM boric acid-potassium dihydrogen phosphate (75:25, v/v) with 5% MeOH adjusted to pH 8.0 with KOH, at a potential of 30 kV. The detection wavelength and temperature are 206 nm and 35 degrees C, respectively.
[Mh] Termos MeSH primário: Inibidores da Enzima Conversora de Angiotensina/análise
Anti-Hipertensivos/análise
Diuréticos/análise
Eletroforese Capilar/métodos
[Mh] Termos MeSH secundário: Enalapril/análise
Enalaprilate/análise
Hidroclorotiazida/análise
Xipamida/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Antihypertensive Agents); 0 (Diuretics); 0J48LPH2TH (Hydrochlorothiazide); 4S9EY0NUEC (Xipamide); 69PN84IO1A (Enalapril); GV0O7ES0R3 (Enalaprilat)
[Em] Mês de entrada:0404
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040317
[St] Status:MEDLINE


  10 / 92 MEDLINE  
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[PMID]:14974328
[Ti] Título:[Proven in the practice. Follow up of the use confirms high trial value].
[Ti] Título:In der Praxis bewährt. Anwendungsbeobachtung bestätigt hohen Stellenwert..
[So] Source:MMW Fortschr Med;145(51-52):37, 2003 Dec 18.
[Is] ISSN:1438-3276
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Anti-Hipertensivos/uso terapêutico
Diuréticos/uso terapêutico
Hipertensão/tratamento farmacológico
Infarto do Miocárdio/prevenção & controle
Xipamida/uso terapêutico
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Anti-Hipertensivos/administração & dosagem
Anti-Hipertensivos/efeitos adversos
Peso Corporal
Ensaios Clínicos como Assunto
Complicações do Diabetes
Diuréticos/administração & dosagem
Diuréticos/efeitos adversos
Seres Humanos
Satisfação do Paciente
Fatores de Risco
Fatores de Tempo
Xipamida/administração & dosagem
Xipamida/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Diuretics); 4S9EY0NUEC (Xipamide)
[Em] Mês de entrada:0404
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040221
[St] Status:MEDLINE



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