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[PMID]:28454702
[Au] Autor:Ellery SJ; Della Gatta PA; Bruce CR; Kowalski GM; Davies-Tuck M; Mockler JC; Murthi P; Walker DW; Snow RJ; Dickinson H
[Ad] Endereço:The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.
[Ti] Título:Creatine biosynthesis and transport by the term human placenta.
[So] Source:Placenta;52:86-93, 2017 Apr.
[Is] ISSN:1532-3102
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Creatine is an amino acid derivative that is involved in preserving ATP homeostasis. Previous studies suggest an important role for the creatine kinase circuit for placental ATP turnover. Creatine is obtained from both the diet and endogenous synthesis, usually along the renal-hepatic axis. However, some tissues with a high-energy demand have an inherent capacity to synthesise creatine. In this study, we determined if the term human placenta has the enzymatic machinary to synthesise creatine. METHODS: Eleven placentae were collected following elective term caesarean section. Samples from the 4 quadrants of each placenta were either fixed in formalin or frozen. qPCR was used to determine the mRNA expression of the creatine synthesising enzymes arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and the creatine transporter (SLC6A8). Protein expression of AGAT and GAMT was quantified by Western blot, and observations of cell localisation of AGAT, GAMT and SLC6A8 made with immunohistochemistry. Synthesis of guanidinoacetate (GAA; creatine precursor) and creatine in placental homogenates was determined via GC-MS and HPLC, respectively. RESULTS: AGAT, GAMT and SLC6A8 mRNA and protein were detected in the human placenta. AGAT staining was identified in stromal and endothelial cells of the fetal capillaries. GAMT and SLC6A8 staining was localised to the syncytiotrophoblast of the fetal villi. Ex vivo, tissue homogenates produce both GAA (4.6 nmol mg protein h ) and creatine (52.8 nmol mg protein h ). DISCUSSION: The term human placenta has the capacity to synthesise creatine. These data present a new understanding of placental energy metabolism.
[Mh] Termos MeSH primário: Amidinotransferases/metabolismo
Creatina/metabolismo
Guanidinoacetato N-Metiltransferase/metabolismo
Proteínas de Membrana Transportadoras/metabolismo
Placenta/metabolismo
[Mh] Termos MeSH secundário: Transporte Biológico
Creatina/biossíntese
Células Endoteliais/metabolismo
Metabolismo Energético/fisiologia
Feminino
Seres Humanos
Gravidez
Células Estromais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Transport Proteins); 0 (creatine transporter); EC 2.1.1.2 (GAMT protein, human); EC 2.1.1.2 (Guanidinoacetate N-Methyltransferase); EC 2.1.4.- (Amidinotransferases); EC 2.1.4.1 (glycine amidinotransferase); MU72812GK0 (Creatine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29291386
[Au] Autor:Said E; Zaitone SA; Eldosoky M; Elsherbiny NM
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
[Ti] Título:Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats.
[So] Source:Chem Biol Interact;281:111-120, 2018 Feb 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. Moreover,it is amongst the most common causes of end-stage renal failure. Inflammation is a crucial player in both development and progression of DN. JAK2/STA3 is a pleotropic cascade reported to regulate diverse inflammatory events. Previous studies reported involvement of JAK2/STA3 signal transduction pathway in diabetes-associated renal injury. In the current study, the inhibitory effect of nifuroxazide (25 mg/kg/day, orally) against inflammatory condition associating diabetic kidney progression in rats was evaluated. The underlying hypothesis is mainly via the inhibitory effect of nifuroxazide on STAT3 signaling. Results revealed that nifuroxazide effectively inhibited STAT3 activation in diabetic male rats, improved glomerular filtration function, protected against diabetes-induced histopathological and ultramicroscopic structural alterations. Further, nifuroxazide treatment significantly reduced renal macrophage infiltration and fibrosis and decreased mRNA and protein levels of TNF-α and IL-18 in diabetic renal tissue. The current findings shed the light on nifuroxazide's efficacy as an alternative anti-inflammatory therapy to hinder the development and progression of DN in diabetic patients mainly via STAT3 inhibition.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Diabetes Mellitus Experimental/complicações
Nefropatias Diabéticas/prevenção & controle
Hidroxibenzoatos/uso terapêutico
Nitrofuranos/uso terapêutico
Fator de Transcrição STAT3/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Nitrogênio da Ureia Sanguínea
Creatina/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/patologia
Nefropatias Diabéticas/etiologia
Fibrose
Hidroxibenzoatos/farmacologia
Interleucina-18/genética
Interleucina-18/metabolismo
Janus Quinase 2/metabolismo
Rim/efeitos dos fármacos
Rim/metabolismo
Rim/patologia
Testes de Função Renal
Macrófagos/citologia
Macrófagos/imunologia
Masculino
Microscopia Eletrônica
Nitrofuranos/farmacologia
Ratos
Fator de Transcrição STAT3/metabolismo
Transdução de Sinais/efeitos dos fármacos
Estreptozocina/toxicidade
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Hydroxybenzoates); 0 (Interleukin-18); 0 (Nitrofurans); 0 (STAT3 Transcription Factor); 0 (Tumor Necrosis Factor-alpha); 5W494URQ81 (Streptozocin); EC 2.7.10.2 (Janus Kinase 2); MU72812GK0 (Creatine); PM5LI0P38J (nifuroxazide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE


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[PMID]:28972194
[Au] Autor:Leehey M; Luo S; Sharma S; Wills AA; Bainbridge JL; Wong PS; Simon DK; Schneider J; Zhang Y; Pérez A; Dhall R; Christine CW; Singer C; Cambi F; Boyd JT
[Ad] Endereço:From the Department of Neurology (M.L.) and Department of Clinical Pharmacy (J.L.B.), Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora; Department of Biostatistics (S.L., Y.Z.), University of Te
[Ti] Título:Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores.
[So] Source:Neurology;89(17):1789-1794, 2017 Oct 24.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To explore the association between metabolic syndrome and the Unified Parkinson's Disease Rating Scale (UPDRS) scores and, secondarily, the Symbol Digit Modalities Test (SDMT). METHODS: This is a secondary analysis of data from 1,022 of 1,741 participants of the National Institute of Neurological Disorders and Stroke Exploratory Clinical Trials in Parkinson Disease Long-Term Study 1, a randomized, placebo-controlled trial of creatine. Participants were categorized as having or not having metabolic syndrome on the basis of modified criteria from the National Cholesterol Education Program Adult Treatment Panel III. Those who had the same metabolic syndrome status at consecutive annual visits were included. The change in UPDRS and SDMT scores from randomization to 3 years was compared in participants with and without metabolic syndrome. RESULTS: Participants with metabolic syndrome (n = 396) compared to those without (n = 626) were older (mean [SD] 63.9 [8.1] vs 59.9 [9.4] years; < 0.0001), were more likely to be male (75.3% vs 57.0%; < 0.0001), and had a higher mean uric acid level (men 5.7 [1.3] vs 5.3 [1.1] mg/dL, women 4.9 [1.3] vs 3.9 [0.9] mg/dL, < 0.0001). Participants with metabolic syndrome experienced an additional 0.6- (0.2) unit annual increase in total UPDRS ( = 0.02) and 0.5- (0.2) unit increase in motor UPDRS ( = 0.01) scores compared with participants without metabolic syndrome. There was no difference in the change in SDMT scores. CONCLUSIONS: Persons with Parkinson disease meeting modified criteria for metabolic syndrome experienced a greater increase in total UPDRS scores over time, mainly as a result of increases in motor scores, compared to those who did not. Further studies are needed to confirm this finding. CLINICALTRIALSGOV IDENTIFIER: NCT00449865.
[Mh] Termos MeSH primário: Antiparkinsonianos/uso terapêutico
Creatina/uso terapêutico
Doenças Metabólicas/complicações
Doença de Parkinson/complicações
Doença de Parkinson/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Método Duplo-Cego
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Doenças Metabólicas/tratamento farmacológico
Meia-Idade
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE III; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antiparkinson Agents); MU72812GK0 (Creatine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004572


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[PMID]:28964325
[Au] Autor:Panagiotou G; Anastasilakis AD; Kynigopoulos G; Skouvaklidou EC; Saridakis ZG; Upadhyay J; Pagkalidou E; Apostolou A; Karagiozoglou-Lampoudi T; Mantzoros CS; USSaAUTHSHS Study Group
[Ad] Endereço:Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
[Ti] Título:Physiological parameters regulating circulating levels of the IGFBP-4/Stanniocalcin-2/PAPP-A axis.
[So] Source:Metabolism;75:16-24, 2017 Oct.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Insulin Growth Factor Binding Protein 4 (IGFBP-4), Stanniocalcin-2 (STC-2) and Pregnancy-Associated Plasma Protein-A (PAPP-A) have a well-documented involvement in several physiological functions in humans but predictors of their circulating levels remain largely unknown. We aimed to identify anthropometric and biochemical parameters associated with circulating levels of IGFBP-4/STC-2/PAPP-A axis (ISPa) cross-sectionally and to study their day-night variation and their regulation in response to mixed meal and exercise. METHODS: One hundred twenty two healthy individuals were evaluated cross-sectionally. Subgroups were subjected to standardized mixed meal ingestion in increasing quantities of 125mL or 250mL, or aerobic exercise for 30min, or day-night rhythm study. Main outcome measurements were circulating IGFBP-4 (total and intact), STC-2 and PAPP-A levels. RESULTS: In multivariate models, the main predictors of serum total IGFBP-4 were PAPP-A and female gender. Intact IGFBP-4 was positively associated with serum creatinine. Height was inversely and female gender and % of total body fat were positively correlated with STC-2. PAPP-A decreased after ingesting both the 125mL (p=0.03) and 250mL quantities (p=0.001), while total IGFBP-4 was reduced after the 250mL quantity (p=0.001). Exercise increased STC-2 and PAPP-A levels (p<0.001 for both). Intact, and to a lesser extent total, IGFBP-4 displayed a cortisol-like day/night variation. CONCLUSIONS: We report for the first time anthropometric and physiological modulators of ISPa serum levels in healthy humans.
[Mh] Termos MeSH primário: Glicoproteínas/sangue
Proteína 4 de Ligação a Fator de Crescimento Semelhante à Insulina/sangue
Peptídeos e Proteínas de Sinalização Intercelular/sangue
Proteína Plasmática A Associada à Gravidez/análise
[Mh] Termos MeSH secundário: Adulto
Ritmo Circadiano
Creatina/sangue
Estudos Transversais
Exercício
Feminino
Seres Humanos
Masculino
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycoproteins); 0 (Insulin-Like Growth Factor Binding Protein 4); 0 (Intercellular Signaling Peptides and Proteins); 0 (STC2 protein, human); EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A); MU72812GK0 (Creatine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


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[PMID]:28864554
[Au] Autor:DeKlotz CMC; Roby KD; Friedlander SF
[Ad] Endereço:MedStar Washington Hospital Center/Georgetown University Hospital, Washington, District of Columbia; and Cynthia.M.DeKlotz@medstar.net.
[Ti] Título:Dietary Supplements, Isotretinoin, and Liver Toxicity in Adolescents: A Retrospective Case Series.
[So] Source:Pediatrics;140(4), 2017 Oct.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isotretinoin is the most effective acne therapy available, but has the potential for a number of adverse side effects, including transaminitis. The iPLEDGE isotretinoin program recommends avoiding some herbals and supplements due to potential side effects. However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. We designed a retrospective chart review to evaluate the symptoms, diagnosis, treatment, and outcome of patients on or preparing to take isotretinoin therapy who were concurrently ingesting protein or herbal supplementation and who developed transaminitis. In 100% (8/8) of cases, dietary supplementation was determined to be at least a possible cause of elevated liver transaminases. In 75% (6/8) of cases, dietary supplement appears to be the most likely cause at some point in their evaluation. Most of our patients' elevations in aspartate aminotransferase and/or alanine aminotransferase were likely caused by supplementation with protein, creatine, or herbal extracts, rather than prescribed isotretinoin or tetracycline antibiotics for acne. Hence, dietary supplementation may cause liver function abnormalities. As supplement usage appears common in teenagers, clinicians should consider counseling their patients to avoid these products, particularly when prescribing known hepatotoxic drugs.
[Mh] Termos MeSH primário: Acne Vulgar/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Fármacos Dermatológicos/efeitos adversos
Suplementos Nutricionais/efeitos adversos
Isotretinoína/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Biomarcadores/metabolismo
Camellia sinensis/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/diagnóstico
Doença Hepática Induzida por Substâncias e Drogas/enzimologia
Creatina/efeitos adversos
Fármacos Dermatológicos/uso terapêutico
Proteínas na Dieta/efeitos adversos
Feminino
Seguimentos
Seres Humanos
Isotretinoína/uso terapêutico
Masculino
Preparações de Plantas/efeitos adversos
Estudos Retrospectivos
Transaminases/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dermatologic Agents); 0 (Dietary Proteins); 0 (Plant Preparations); EC 2.6.1.- (Transaminases); EH28UP18IF (Isotretinoin); MU72812GK0 (Creatine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE


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[PMID]:28842444
[Au] Autor:Nedelska Z; Przybelski SA; Lesnick TG; Schwarz CG; Lowe VJ; Machulda MM; Kremers WK; Mielke MM; Roberts RO; Boeve BF; Knopman DS; Petersen RC; Jack CR; Kantarci K
[Ad] Endereço:From the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charl
[Ti] Título:H-MRS metabolites and rate of ß-amyloid accumulation on serial PET in clinically normal adults.
[So] Source:Neurology;89(13):1391-1399, 2017 Sep 26.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess whether noninvasive proton magnetic resonance spectroscopy ( H-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of ß-amyloid (Aß) accumulation on serial PET in clinically normal (CN) older adults. METHODS: Consecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent H-MRS from the posterior cingulate voxel and longitudinal C-Pittsburgh compound B (PiB)-PET were included. The rate of Aß accumulation by serial cortical PiB standardized uptake value ratios was estimated as a function of baseline H-MRS metabolite ratios and time using mixed-effect models adjusted for age, sex, and ε4. Effect of ε4 on the relationship between baseline MRS and an increased rate of Aß accumulation was also assessed. RESULTS: Among all participants, a higher myo-inositol (mI)/creatine ( = 0.011) and a lower -acetylaspartate/mI ( = 0.006) at baseline were associated with an increased Aß accumulation over time after adjusting for age, sex, and ε4. ε4 did not modify the association of baseline H-MRS metabolite ratios and rate of Aß accumulation. However, ε4 carriers accumulated Aß faster than noncarriers regardless of the baseline Aß load ( = 0.001). CONCLUSION: Among CN older adults, early metabolic alterations on H-MRS and ε4 status are independently associated with an increased rate of Aß accumulation. Our findings could have important implications for early diagnosis and identification of individuals for secondary prevention trials, because an increased rate of Aß accumulation in CN older adults may confer a higher risk for cognitive decline and mild cognitive impairment.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/metabolismo
Encéfalo/diagnóstico por imagem
Encéfalo/metabolismo
Tomografia por Emissão de Pósitrons
Espectroscopia de Prótons por Ressonância Magnética
[Mh] Termos MeSH secundário: Idoso
Envelhecimento/metabolismo
Apolipoproteína E4/genética
Ácido Aspártico/análogos & derivados
Ácido Aspártico/metabolismo
Creatina/metabolismo
Feminino
Seguimentos
Heterozigoto
Seres Humanos
Inositol/metabolismo
Estudos Longitudinais
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Apolipoprotein E4); 30KYC7MIAI (Aspartic Acid); 4L6452S749 (Inositol); 997-55-7 (N-acetylaspartate); MU72812GK0 (Creatine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004421


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[PMID]:28778442
[Au] Autor:Zhu DS; Yu L; Li M; Han L; Huang XX; Wang XQ; Yang XL; Zhu Y; Zhou XJ; Guan YT
[Ad] Endereço:Department of Neurology, Renji Hospital, School of medicine, Shanghai Jiaotong University, Shanghai 200127, China.
[Ti] Título:High serum creatinine is associated with reduction of vision impaired in patients with NMOSD.
[So] Source:J Neuroimmunol;310:32-37, 2017 Sep 15.
[Is] ISSN:1872-8421
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Serum creatinine (SCR) has been found to be neuroprotective in neurodegenerative disease. However, whether SCR is a protective factor for vision impaired in neuromyelitis optica spectrum disorder (NMOSD) is unclear. This study to determine the relationship between SCR level and vision impaired in NMOSD patients through multivariate-adjusted linear regression analyses. Our result showed that high level of SCR was associated with a low occurrence of vision impaired, and the association was independent after adjustment for confounding risk factors and hierarchical analysis. Therefore, these results demonstrated that higher SCR level is a protective factor of vision impaired in male NMOSD patients.
[Mh] Termos MeSH primário: Creatina/sangue
Neuromielite Óptica/complicações
Transtornos da Visão/sangue
Transtornos da Visão/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Aquaporina 4/imunologia
Estudos Transversais
Avaliação da Deficiência
Feminino
Seres Humanos
Imunoglobulina G/sangue
Modelos Lineares
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Neuromielite Óptica/diagnóstico por imagem
Estudos Retrospectivos
Índice de Gravidade de Doença
Transtornos da Visão/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AQP4 protein, human); 0 (Aquaporin 4); 0 (Immunoglobulin G); MU72812GK0 (Creatine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


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[PMID]:28766947
[Au] Autor:Zhang L; Wang X; Li J; Zhu X; Gao F; Zhou G
[Ad] Endereço:College of Animal Science and Technology, Jiangsu Key Laboratory of Animal Origin Food Production and Safety Guarantee, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanji
[Ti] Título:Creatine Monohydrate Enhances Energy Status and Reduces Glycolysis via Inhibition of AMPK Pathway in Pectoralis Major Muscle of Transport-Stressed Broilers.
[So] Source:J Agric Food Chem;65(32):6991-6999, 2017 Aug 16.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Creatine monohydrate (CMH) contributes to reduce transport-induced muscle rapid glycolysis and improve meat quality of broilers, but the underlying mechanism is still unknown. Therefore, this study aimed to investigate the molecular mechanisms underlying the ameliorative effects of CMH on muscle glycolysis metabolism of transported broilers during summer. The results showed that 3 h transport during summer elevated chicken live weight loss and plasma corticosterone concentration; decreased muscle concentrations of ATP, creatine, and energy charge value; increased muscle AMP concentration and AMP/ATP ratio; and upregulated muscle mRNA expression of LKB1 and AMPKα2, as well as protein expression of p-LKB1 and p-AMPKα , which subsequently resulted in rapid glycolysis in the pectoralis major muscle and consequent reduction of meat quality. Dietary addition of CMH at 1200 mg/kg ameliorated transport-induced rapid muscle glycolysis and reduction of meat quality via enhancement of the energy-buffering capacity of intramuscular phosphocreatine/creatine system and inhibition of AMPK pathway.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Galinhas/metabolismo
Creatina/metabolismo
Músculo Esquelético/metabolismo
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Metabolismo Energético
Glicólise
Carne/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.11.31 (AMP-Activated Protein Kinases); MU72812GK0 (Creatine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02740


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[PMID]:28726255
[Au] Autor:Çekiç EG; Filiz Basaran N; Dogan V; Biteker M
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine, Mugla Sitki Koçman University, Mugla, Turkey.
[Ti] Título:Creatine supplementation on cardiac autonomic functions.
[So] Source:Pacing Clin Electrophysiol;40(9):1045, 2017 09.
[Is] ISSN:1540-8159
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Creatina
Suplementos Nutricionais
[Mh] Termos MeSH secundário: Sistema Nervoso Autônomo
Fenômenos Fisiológicos Cardiovasculares
Coração
Seres Humanos
Músculo Esquelético
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
MU72812GK0 (Creatine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1111/pace.13150


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[PMID]:28714074
[Au] Autor:Wu HC; Dachet F; Ghoddoussi F; Bagla S; Fuerst D; Stanley JA; Galloway MP; Loeb JA
[Ad] Endereço:Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, U.S.A.
[Ti] Título:Altered metabolomic-genomic signature: A potential noninvasive biomarker of epilepsy.
[So] Source:Epilepsia;58(9):1626-1636, 2017 Sep.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to identify noninvasive biomarkers of human epilepsy that can reliably detect and localize epileptic brain regions. Having noninvasive biomarkers would greatly enhance patient diagnosis, patient monitoring, and novel therapy development. At the present time, only surgically invasive, direct brain recordings are capable of detecting these regions with precision, which severely limits the pace and scope of both clinical management and research progress in epilepsy. METHODS: We compared high versus low or nonspiking regions in nine medically intractable epilepsy surgery patients by performing integrated metabolomic-genomic-histological analyses of electrically mapped human cortical regions using high-resolution magic angle spinning proton magnetic resonance spectroscopy, cDNA microarrays, and histological analysis. RESULTS: We found a highly consistent and predictive metabolite logistic regression model with reduced lactate and increased creatine plus phosphocreatine and choline, suggestive of a chronically altered metabolic state in epileptic brain regions. Linking gene expression, cellular, and histological differences to these key metabolites using a hierarchical clustering approach predicted altered metabolic vascular coupling in the affected regions. Consistently, these predictions were validated histologically, showing both neovascularization and newly discovered, millimeter-sized microlesions. SIGNIFICANCE: Using a systems biology approach on electrically mapped human cortex provides new evidence for spatially segregated, metabolic derangements in both neurovascular and synaptic architecture in human epileptic brain regions that could be a noninvasively detectable biomarker of epilepsy. These findings both highlight the immense power of a systems biology approach and identify a potentially important role that magnetic resonance spectroscopy can play in the research and clinical management of epilepsy.
[Mh] Termos MeSH primário: Epilepsia/metabolismo
Metabolômica
[Mh] Termos MeSH secundário: Adolescente
Biomarcadores
Encéfalo/metabolismo
Criança
Pré-Escolar
Colina/metabolismo
Creatina/metabolismo
Epilepsia/genética
Feminino
Marcadores Genéticos
Seres Humanos
Lactente
Ácido Láctico/metabolismo
Espectroscopia de Ressonância Magnética
Masculino
Análise de Sequência com Séries de Oligonucleotídeos
Fosfocreatina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Genetic Markers); 020IUV4N33 (Phosphocreatine); 33X04XA5AT (Lactic Acid); MU72812GK0 (Creatine); N91BDP6H0X (Choline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13848



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