Base de dados : MEDLINE
Pesquisa : D02.078.370.460 [Categoria DeCS]
Referências encontradas : 3063 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 307 ir para página                         

  1 / 3063 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27890860
[Au] Autor:Freyhardt P; Donners R; Riemert A; Schnorr J; Stolzenburg N; Rinnenthal JL; Bernhardt U; Hamm B; Günther RW; Streitparth F
[Ad] Endereço:Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Renal denervation by CT-guided periarterial injection of hyperosmolar saline, vincristine, paclitaxel and guanethidine in a pig model.
[So] Source:EuroIntervention;12(18):e2262-e2270, 2017 Apr 07.
[Is] ISSN:1969-6213
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:AIMS: The aim of the study was to evaluate the feasibility, safety and efficacy of renal sympathetic denervation with CT-guided periarterial injection of potentially neurolytic agents in pigs. METHODS AND RESULTS: Unilateral injection of formulations containing either 5M hyperosmolar saline, vincristine, paclitaxel or guanethidine around the renal artery was performed in 24 normotensive pigs with six animals per group. Needle placement and injections were performed under CT fluoroscopy guidance. Blood pressure measurements and CT scans were performed immediately before and after the intervention and four weeks after treatment. After euthanasia, norepinephrine (NE) concentrations of both kidneys were determined. The renal arteries and surrounding tissue were examined histologically to evaluate nerve fibre degeneration. Procedures were technically successful with good periarterial distribution of the injectant in all but one pig in the guanethidine group. No major adverse events or post-interventional complications occurred. In the vincristine group, NE concentrations of the renal parenchyma were lower on the treated side in all pigs with a mean decrease of 53% (38%-62%, p<0.01) compared to the contralateral control. Correspondingly, histological examination revealed neural degeneration in all animals treated with vincristine. In the other groups, no significant drop of NE values, or histological signs of nerve fibre degeneration were found. CONCLUSIONS: CT-guided periarterial injection of the different substances was feasible and safe. Renal sympathetic denervation was achieved with vincristine. In contrast, hyperosmolar saline, paclitaxel and guanethidine do not seem to be appropriate for renal denervation in a pig model at the dosage used.
[Mh] Termos MeSH primário: Guanetidina/administração & dosagem
Rim/inervação
Paclitaxel/administração & dosagem
Simpatectomia/métodos
Tomografia Computadorizada por Raios X/métodos
Vincristina/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea
Rim/química
Rim/diagnóstico por imagem
Rim/patologia
Norepinefrina/análise
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
5J49Q6B70F (Vincristine); P88XT4IS4D (Paclitaxel); X4W3ENH1CV (Norepinephrine); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE


  2 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27124242
[Au] Autor:da Silva MT; Marques RB; Batista-Lima FJ; Soares MA; Dos Santos AA; Magalhães PJ; de Assis Oliveira F; de Castro Almeida FR
[Ad] Endereço:Department of Physical Education, Federal University of Piaui, Teresina, PI, Brazil.
[Ti] Título:α-Terpineol Induces Gastric Retention of Liquids by Inhibiting Vagal Parasympathetic Pathways in Rats.
[So] Source:Planta Med;82(15):1329-1334, 2016 Oct.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:-Terpineol is a monoterpene with smooth muscle relaxant properties. In this study, its effects on the gastric emptying rate of awake rats were evaluated with emphasis on the mode by which it induces gastrointestinal actions. Administered by gavage, -terpineol (50 mg/kg) delayed gastric emptying of a liquid test meal at 10 min postprandial. Hexamethonium or guanethidine did not interfere with the retarding effect induced by -terpineol, but atropine and L-N -nitroarginine methyl ester abolished it. In vagotomized rats, -terpineol did not delay gastric emptying. In isolated strips of gastric fundus, concentration-effect curves in response to carbamylcholine were higher in magnitude after treatment with the monoterpene. -Terpineol (1 to 2000 µM) relaxed sustained contractions induced by carbamylcholine or a high K concentration in a concentration-dependent manner. This relaxing effect was not affected by the presence of L-N -nitroarginine methyl ester, 1 H-[1, 2, 4]oxadiazolo[4,3-a]quinoxalin-1-one, tetraethylammonium, or atropine. Smooth muscle contractions induced by electrical field stimulation were inhibited by -terpineol. In conclusion, -terpineol induced gastric retention in awake rats through mechanisms that depended on intact vagal innervation to the stomach, which involved cholinergic/nitrergic signalling. Such a retarding effect induced by -terpineol appears not to result from a direct action of the monoterpene on gastric smooth muscle cells.
[Mh] Termos MeSH primário: Cicloexenos/farmacologia
Esvaziamento Gástrico/efeitos dos fármacos
Fundo Gástrico/efeitos dos fármacos
Monoterpenos/farmacologia
Nervo Vago/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Atropina/farmacologia
Carbacol/farmacologia
Cicloexenos/administração & dosagem
Relação Dose-Resposta a Droga
Esvaziamento Gástrico/fisiologia
Guanetidina/farmacologia
Masculino
Monoterpenos/administração & dosagem
NG-Nitroarginina Metil Éster/farmacologia
Óxido Nítrico/metabolismo
Técnicas de Cultura de Órgãos
Potássio/farmacologia
Ratos Wistar
Simpatolíticos/farmacologia
Vagotomia
Nervo Vago/metabolismo
Nervo Vago/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Monoterpenes); 0 (Sympatholytics); 21334LVV8W (alpha-terpineol); 31C4KY9ESH (Nitric Oxide); 7C0697DR9I (Atropine); 8Y164V895Y (Carbachol); RWP5GA015D (Potassium); V55S2QJN2X (NG-Nitroarginine Methyl Ester); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE


  3 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27085835
[Au] Autor:Zahner MR; Liu CN; Okerberg CV; Opsahl AC; Bobrowski WF; Somps CJ
[Ad] Endereço:Drug Safety Research & Development, Pfizer Worldwide Research and Development, Groton, CT 06340, United States. Electronic address: Matthew.Zahner@pfizer.com.
[Ti] Título:Neurophysiological assessment of sympathetic cardiovascular activity after loss of postganglionic neurons in the anesthetized rat.
[So] Source:J Pharmacol Toxicol Methods;80:59-67, 2016 Jul-Aug.
[Is] ISSN:1873-488X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The goal of this study was to determine the degree of sympathetic postganglionic neuronal loss required to impair cardiovascular-related sympathetic activity. To produce neuronal loss separate groups of rats were treated daily with guanethidine for either 5days or 11days, followed by a recovery period. Sympathetic activity was measured by renal sympathetic nerve activity (RSNA). Stereology of thoracic (T13) ganglia was performed to determine neuronal loss. Despite loss of more than two thirds of neurons in T13 ganglia in both treated groups no effect on resting blood pressure (BP) or heart rate (HR) was detected. Basal RSNA in rats treated for 5days (0.61±0.10µV∗s) and 11days (0.37±0.08µV∗s) was significantly less than vehicle-treated rats (0.99±0.13µV∗s, p<0.05). Increases in RSNA by baroreceptor unloading were significantly lower in 5-day (1.09±0.19µV∗s) and 11-day treated rats (0.59±0.11µV∗s) compared with vehicle-treated rats (1.82±0.19µV∗s, p<0.05). Increases in RSNA to chemoreceptor stimulation were significantly lower in 5-day treated rats (1.54±0.25µV∗s) compared with vehicle-treated rats (2.69±0.23µV∗s, p<0.05). Increases in RSNA in 11-day treated rats were significantly lower (0.75±0.15µV∗s, p<0.05) compared with both vehicle-treated and 5-day treated rats. A positive correlation of neurons to sympathetic responsiveness but not basal activity was detected. These data suggest that diminished capacity for reflex sympathetic responsiveness rather than basal activity alone must be assessed for complete detection of neurophysiological cardiovascular impairment.
[Mh] Termos MeSH primário: Anestesia/efeitos adversos
Sistema Cardiovascular/efeitos dos fármacos
Fibras Simpáticas Pós-Ganglionares
Sistema Nervoso Simpático/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Sistema Cardiovascular/inervação
Guanetidina/toxicidade
Frequência Cardíaca/efeitos dos fármacos
Rim/efeitos dos fármacos
Rim/inervação
Masculino
Pressorreceptores/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Simpatolíticos/toxicidade
Nervos Torácicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sympatholytics); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160418
[St] Status:MEDLINE


  4 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26657181
[Au] Autor:Lam M; Mitsui R; Hashitani H
[Ad] Endereço:Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Kawasumi-1, Mizuho-ku, Nagoya 467-8601, Japan. Electronic address: mishella86@gmail.com.
[Ti] Título:Electrical properties of purinergic transmission in smooth muscle of the guinea-pig prostate.
[So] Source:Auton Neurosci;194:8-16, 2016 Jan.
[Is] ISSN:1872-7484
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Prostatic smooth muscle develops spontaneous myogenic tone which is modulated by autonomic neuromuscular transmission. This study aimed to investigate the role of purinergic transmission in regulating electrical activity of prostate smooth muscle and whether its contribution may be altered with age. Intracellular recordings were simultaneously made with isometric tension recordings in smooth muscle preparations of the guinea-pig prostate. Immunostaining for P2X1 receptors on whole mount preparations was also performed. In prostate preparations which generated spontaneous slow waves, electrical field stimulation (EFS)-evoked excitatory junction potentials (EJPs) which were abolished by guanethidine (10 µM), α-ß-methylene ATP (10 µM) or pyridoxal phosphate-6-azophenyl-2,4-disulfonic acid (PPADS, 10 µM) but not phentolamine (1 µM). Consistently, immunostaining revealed the expression of P2X1 receptors on prostatic smooth muscle. EJPs themselves did not cause contractions, but EJPs could sum to trigger a slow wave and associated contraction. Yohimbine (1 µM) and 3,7-dimethyl-1-propargylxanthine (DMPX, 10 µM) but not propranolol (1 µM) potentiated EJPs. Although properties of EJPs were not different between young and aging guinea-pig prostates, ectoATPase inhibitor ARL 67156 (100 µM) augmented EJP amplitudes by 64.2 ± 29.6% in aging animals, compared to 22.1 ± 19.9% in young animals. These results suggest that ATP released from sympathetic nerves acts on P2X1 purinoceptors located on prostate smooth muscle to evoke EJPs, while pre-junctional α2-adrenergic and adenosine A2 receptors may play a role in preventing excessive transmitter release. Age-related up-regulation of enzymatic ATP breakdown may be a compensatory mechanism for the enhanced purinergic transmission which would cause hypercontractility arising from increased ATP release in older animals.
[Mh] Termos MeSH primário: Estimulação Elétrica
Potenciais da Membrana/fisiologia
Músculo Liso/fisiologia
Próstata
Receptores Purinérgicos P2X1/metabolismo
[Mh] Termos MeSH secundário: Adrenérgicos/farmacologia
Antagonistas de Receptores Adrenérgicos alfa 2/farmacologia
Fatores Etários
Anestésicos Locais/farmacologia
Animais
Guanetidina/farmacologia
Cobaias
Masculino
Potenciais da Membrana/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Purinérgicos/farmacologia
Transmissão Sináptica/efeitos dos fármacos
Transmissão Sináptica/fisiologia
Tetrodotoxina/farmacologia
Ioimbina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic Agents); 0 (Adrenergic alpha-2 Receptor Antagonists); 0 (Anesthetics, Local); 0 (Purinergic Agents); 0 (Receptors, Purinergic P2X1); 2Y49VWD90Q (Yohimbine); 4368-28-9 (Tetrodotoxin); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE


  5 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26281717
[Au] Autor:McKim DB; Patterson JM; Wohleb ES; Jarrett BL; Reader BF; Godbout JP; Sheridan JF
[Ad] Endereço:Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio; Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio.
[Ti] Título:Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.
[So] Source:Biol Psychiatry;79(10):803-813, 2016 May 15.
[Is] ISSN:1873-2402
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neuroinflammatory signaling may contribute to the pathophysiology of chronic anxiety disorders. Previous work showed that repeated social defeat (RSD) in mice promoted stress-sensitization that was characterized by the recurrence of anxiety following subthreshold stress 24 days after RSD. Furthermore, splenectomy following RSD prevented the recurrence of anxiety in stress-sensitized mice. We hypothesize that the spleen of RSD-exposed mice became a reservoir of primed monocytes that were released following neuroendocrine activation by subthreshold stress. METHODS: Mice were subjected to subthreshold stress (i.e., single cycle of social defeat) 24 days after RSD, and immune and behavioral measures were taken. RESULTS: Subthreshold stress 24 days after RSD re-established anxiety-like behavior that was associated with egress of Ly6C(hi) monocytes from the spleen. Moreover, splenectomy before RSD blocked monocyte trafficking to the brain and prevented anxiety-like behavior following subthreshold stress. Splenectomy, however, had no effect on monocyte accumulation or anxiety when determined 14 hours after RSD. In addition, splenocytes cultured 24 days after RSD exhibited a primed inflammatory phenotype. Peripheral sympathetic inhibition before subthreshold stress blocked monocyte trafficking from the spleen to the brain and prevented the re-establishment of anxiety in RSD-sensitized mice. Last, ß-adrenergic antagonism also prevented splenic monocyte egress after acute stress. CONCLUSIONS: The spleen served as a unique reservoir of primed monocytes that were readily released following sympathetic activation by subthreshold stress that promoted the re-establishment of anxiety. Collectively, the long-term storage of primed monocytes in the spleen may have a profound influence on recurring anxiety disorders.
[Mh] Termos MeSH primário: Ansiedade/fisiopatologia
Monócitos/fisiologia
Baço/fisiopatologia
Estresse Psicológico/fisiopatologia
Sistema Nervoso Simpático/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Ansiedade/etiologia
Encéfalo/efeitos dos fármacos
Encéfalo/fisiopatologia
Movimento Celular/efeitos dos fármacos
Movimento Celular/fisiologia
Estudos de Coortes
Modelos Animais de Doenças
Dominação-Subordinação
Guanetidina/farmacologia
Masculino
Camundongos Endogâmicos C57BL
Monócitos/efeitos dos fármacos
Neuroimunomodulação/efeitos dos fármacos
Neuroimunomodulação/fisiologia
Baço/efeitos dos fármacos
Esplenectomia
Estresse Psicológico/complicações
Sistema Nervoso Simpático/efeitos dos fármacos
Simpatolíticos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sympatholytics); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170916
[Lr] Data última revisão:
170916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150819
[St] Status:MEDLINE


  6 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27259308
[Au] Autor:Song J; Yin J; Chen JD
[Ad] Endereço:Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA.
[Ti] Título:Inhibitory Effects and Sympathetic Mechanisms of Distension in the Distal Organs on Small Bowel Motility and Slow Waves in Canine.
[So] Source:Cell Biochem Biophys;73(3):665-72, 2015 Dec.
[Is] ISSN:1559-0283
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rectal distension (RD) is known to induce intestinal dysmotility. Few studies were performed to compare effects of RD, colon distension (CD) and duodenal distension (DD) on small bowel motility. This study aimed to investigate effects and underlying mechanisms of distensions in these regions on intestinal motility and slow waves. Eight dogs chronically implanted with a duodenal fistula, a proximal colon fistula, and intestinal serosal electrodes were studied in six sessions: control, RD, CD, DD, RD + guanethidine, and CD + guanethidine. Postprandial intestinal contractions and slow waves were recorded for the assessment of intestinal motility. The electrocardiogram was recorded for the assessment of autonomic functions. (1) Isobaric RD and CD suppressed intestinal contractions (contractile index: 6.0 ± 0.4 with RD vs. 9.9 ± 0.9 at baseline, P = 0.001, 5.3 ± 0.2 with CD vs. 7.7 ± 0.8 at baseline, P = 0.008). Guanethidine at 3 mg/kg iv was able to partially block the effects. (2) RD and CD reduced the percentage of normal intestinal slow waves from 92.1 ± 2.8 to 64.2 ± 3.4 % (P < 0.001) and from 90 ± 2.7 to 69.2 ± 3.7 % (P = 0.01), respectively. Guanethidine could eliminate these inhibitory effects. (3) DD did not induce any changes in small intestinal contractions and slow waves (P > 0.05). (4) The spectral analysis of the heart rate variability showed that both RD and CD increased sympathetic activity (LF) and reduced vagal activity (HF) (P < 0.05). Isobaric RD and CD could inhibit postprandial intestinal motility and impair intestinal slow waves, which were mediated via the sympathetic pathway. However, DD at a site proximal to the measurement site did not seem to impair small intestinal contractions or slow waves.
[Mh] Termos MeSH primário: Constipação Intestinal/fisiopatologia
Motilidade Gastrointestinal
Intestino Delgado/inervação
Sistema Nervoso Simpático/fisiopatologia
[Mh] Termos MeSH secundário: Adrenérgicos/farmacologia
Animais
Cães
Feminino
Guanetidina/farmacologia
Intestino Delgado/fisiologia
Intestino Delgado/fisiopatologia
Nervos Periféricos/efeitos dos fármacos
Nervos Periféricos/fisiologia
Nervos Periféricos/fisiopatologia
Sistema Nervoso Simpático/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic Agents); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE
[do] DOI:10.1007/s12013-015-0679-4


  7 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26376854
[Au] Autor:Nascimento FP; Magnussen C; Yousefpour N; Ribeiro-da-Silva A
[Ad] Endereço:Department of Pharmacology and Therapeutics, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 1215, Montreal, QC, H3G 1Y6, Canada. ney.pintodonascimento@gmail.com.
[Ti] Título:Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain.
[So] Source:Mol Pain;11:59, 2015 Sep 17.
[Is] ISSN:1744-8069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to model neuropathic pain. Because nociceptive information is first detected in skin, it is important to understand how alterations in peripheral innervation contribute to pain in each model. Over 16 weeks in male rats, changes in sensory and autonomic innervation of the skin were described after cuff and SNI using immunohistochemistry to label myelinated (neurofilament 200 positive-NF200+) and peptidergic (calcitonin gene-related peptide positive-CGRP+) primary afferents and sympathetic fibres (dopamine ß-hydroxylase positive-DBH+) RESULTS: Cuff and SNI caused an early loss and later reinnervation of NF200 and CGRP fibres in the plantar hind paw skin. In both models, DBH+ fibres sprouted into the upper dermis of the plantar skin 4 and 6 weeks after injury. Despite these similarities, behavioural pain measures were significantly different in each model. Sympathectomy using guanethidine significantly alleviated mechanical allodynia 6 weeks after cuff, when peak sympathetic sprouting was observed, having no effect at 2 weeks, when fibres were absent. In SNI animals, mechanical allodynia in the lateral paw was significantly improved by guanethidine at 2 and 6 weeks, and the development of cold hyperalgesia, which roughly paralleled the appearance of ectopic sympathetic fibres, was alleviated by guanethidine at 6 weeks. Sympathetic fibres did not sprout into the dorsal root ganglia at 2 or 6 weeks, indicating their unimportance to pain behaviour in these two models. CONCLUSIONS: Alterations in sympathetic innervation in the skin represents an important mechanism that contributes to pain in cuff and SNI models of neuropathic pain.
[Mh] Termos MeSH primário: Fibras Adrenérgicas/metabolismo
Neuralgia/patologia
Nervo Isquiático/patologia
Pele/inervação
[Mh] Termos MeSH secundário: Fibras Adrenérgicas/efeitos dos fármacos
Animais
Comportamento Animal/efeitos dos fármacos
Peptídeo Relacionado com Gene de Calcitonina/metabolismo
Temperatura Baixa
Derme/efeitos dos fármacos
Derme/inervação
Derme/patologia
Modelos Animais de Doenças
Dopamina beta-Hidroxilase/metabolismo
Gânglios Espinais/efeitos dos fármacos
Gânglios Espinais/patologia
Guanetidina/farmacologia
Hiperalgesia/complicações
Hiperalgesia/patologia
Masculino
Neuralgia/complicações
Ratos Sprague-Dawley
Nervo Isquiático/efeitos dos fármacos
Pele/efeitos dos fármacos
Pele/patologia
Simpatectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
83652-28-2 (Calcitonin Gene-Related Peptide); EC 1.14.17.1 (Dopamine beta-Hydroxylase); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150918
[St] Status:MEDLINE
[do] DOI:10.1186/s12990-015-0062-x


  8 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25818186
[Au] Autor:Silva LC; Miranda e Castor MG; Souza TC; Duarte ID; Romero TR
[Ad] Endereço:Department of Pharmacology, Institute of Biological Sciences, ICB-UFMG, Av. Antônio Carlos, 6627, Pampulha, CEP 31.270-100 Belo Horizonte, MG, Brazil.
[Ti] Título:NSAIDs induce peripheral antinociception by interaction with the adrenergic system.
[So] Source:Life Sci;130:7-11, 2015 Jun 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: We evaluated the role of adrenergic systems on the peripheral antinociception induced by dipyrone and diclofenac. Mainmethods: The rat pawpressure test, inwhich sensitivity is increased by intraplantar injection of prostaglandin E2, was used to examine the peripheral effects of locally administered drugs. KEY FINDINGS: Dipyrone (10, 20 and 40 µg) and diclofenac (5, 10 and 20 µg) administered locally into the right paw elicited a dose-dependent antinociceptive effect, which was demonstrated to be local; the injection of drugs into the ipsilateral and contralateral hindpaws demonstrated an effect only in the ipsilateral paw because only the treated paw produced an antinociceptive effect. To test the adrenergic system, we used guanethidine (30 mg/kg) to deplete noradrenalin from noradrenergic vesicles. Guanethidine antagonized the peripheral antinociception induced by diclofenac and dipyrone. Yohimbine (2.5, 5, 10, or 20 µg/paw) a nonselective α2-adrenergic receptor antagonist antagonized the peripheral antinociception induced by diclofenac (20 µg/paw) and dipyrone (40 µg/paw). Rauwolscine (Rau; 10, 15, 20 µg), a selective α2C-adrenoreceptor, was able to block the peripheral antinociception induced by NSAIDs. The other specific α2A,B and D-adrenoreceptor antagonists (BRL 44480, imiloxan and RX 821002, respectively) did not modify the peripheral antinociception. However, prazosin (0.5, 1, and 2 µg/paw), an α1 receptor antagonist, and propranolol (0.3, 0.6 or 1.2 µg/paw), a ß-adrenoreceptor antagonist, antagonized the antinociception induced by diclofenac (20 µg/paw) and dipyrone (40 µg/paw). SIGNIFICANCE: Dipyrone and diclofenac produce peripheral antinociception, which involves the release of NA and interaction with α1, α2C and ß-adrenoreceptors.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Diclofenaco/farmacologia
Dipirona/farmacologia
Receptores Adrenérgicos alfa/efeitos dos fármacos
Receptores Adrenérgicos beta/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/administração & dosagem
Diclofenaco/administração & dosagem
Dipirona/administração & dosagem
Relação Dose-Resposta a Droga
Guanetidina/farmacologia
Masculino
Norepinefrina/metabolismo
Prazosina/administração & dosagem
Prazosina/farmacologia
Ratos
Ratos Wistar
Receptores Adrenérgicos alfa/metabolismo
Receptores Adrenérgicos beta/metabolismo
Ioimbina/administração & dosagem
Ioimbina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Receptors, Adrenergic, alpha); 0 (Receptors, Adrenergic, beta); 144O8QL0L1 (Diclofenac); 2Y49VWD90Q (Yohimbine); 6429L0L52Y (Dipyrone); X4W3ENH1CV (Norepinephrine); XM03YJ541D (Prazosin); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150331
[St] Status:MEDLINE


  9 / 3063 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25137035
[Au] Autor:Ovais M; Srivastava SK; Sumoona S; Mubashshir M
[Ad] Endereço:a Department of Biosciences , Barkatullah University , Bhopal , Madhya Pradesh , India and.
[Ti] Título:Evidence for the presence of novel ß-melatonin receptors along with classical α-melatonin receptors in the fish Rasbora daniconius (Ham.).
[So] Source:J Recept Signal Transduct Res;35(4):238-48, 2015.
[Is] ISSN:1532-4281
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of melatonin (MT) were examined on the isolated scale melanophores from dorso-lateral (D-L) and band regions of a tropical fish Rasbora daniconius. Our study primarily aimed for further depiction of the signaling receptors involved in MT mediated pigment translocations in the fish. Melanophore Size Index (MSI) was employed as a recording parameter for the responses of melanophores to MT and various antagonists. MT has induced aggregation as well as dispersion in D-L region and aggregation in band region melanophores during summer season. During winter, MT-induced responses were only of aggregatory type in D-L region, while in the band region there was an increase in the sensitivity. The responses of the melanophores to MT were reversible. The aggregation of innervated melanophores induced by MT on the D-L and band regions was partially mediated through the neurotransmitters released under the influence of MT and partially by the specific MT receptors. Luzindole and K185 have completely blocked the aggregatory responses of D-L and band region melanophores. Aggregatory receptors may be of the conventional α-MT type. Dispersion of D-L and band region melanophores induced by MT in the presence of various antagonists and on denervated band region could be the result of activation of ß-MT receptors of dispersive nature. Presence of α and ß MT receptors is thus indicated in this fish melanophores.
[Mh] Termos MeSH primário: Cyprinidae/metabolismo
Proteínas de Peixes/metabolismo
Receptores de Melatonina/metabolismo
[Mh] Termos MeSH secundário: Animais
Agregação Celular/efeitos dos fármacos
Cyprinidae/anatomia & histologia
Denervação
Relação Dose-Resposta a Droga
Feminino
Proteínas de Peixes/antagonistas & inibidores
Proteínas de Peixes/classificação
Guanetidina/farmacologia
Indóis/farmacologia
Masculino
Melanóforos/efeitos dos fármacos
Melanóforos/metabolismo
Melatonina/administração & dosagem
Melatonina/metabolismo
Fentolamina/farmacologia
Propranolol/farmacologia
Receptores de Melatonina/antagonistas & inibidores
Receptores de Melatonina/classificação
Triptaminas/farmacologia
Ioimbina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins); 0 (Indoles); 0 (K 185); 0 (Receptors, Melatonin); 0 (Tryptamines); 117946-91-5 (luzindole); 2Y49VWD90Q (Yohimbine); 9Y8NXQ24VQ (Propranolol); JL5DK93RCL (Melatonin); Z468598HBV (Phentolamine); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151020
[Lr] Data última revisão:
151020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140820
[St] Status:MEDLINE
[do] DOI:10.3109/10799893.2014.951896


  10 / 3063 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25456701
[Au] Autor:Madias JE
[Ad] Endereço:Icahn School of Medicine at Mount Sinai, New York, NY, United States; Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY, United States. Electronic address: madiasj@nychhc.org.
[Ti] Título:Reserpine, mecamilamine, guanethidine, atropine for patients with Takotsubo syndrome?
[So] Source:Int J Cardiol;177(3):1078-9, 2014 Dec 20.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Atropina/uso terapêutico
Guanetidina/uso terapêutico
Mecamilamina/uso terapêutico
Reserpina/uso terapêutico
Cardiomiopatia de Takotsubo/tratamento farmacológico
[Mh] Termos MeSH secundário: Seres Humanos
Cardiomiopatia de Takotsubo/diagnóstico
[Pt] Tipo de publicação:LETTER; REVIEW
[Nm] Nome de substância:
6EE945D3OK (Mecamylamine); 7C0697DR9I (Atropine); 8B1QWR724A (Reserpine); ZTI6C33Q2Q (Guanethidine)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150202
[Lr] Data última revisão:
150202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE



página 1 de 307 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde