Base de dados : MEDLINE
Pesquisa : D02.092.050 [Categoria DeCS]
Referências encontradas : 669 [refinar]
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[PMID]:29355689
[Au] Autor:Gryshkova V; Fleming A; McGhan P; De Ron P; Fleurance R; Valentin JP; Nogueira da Costa A
[Ad] Endereço:Investigative Toxicology, Non-Clinical Development, UCB Biopharma SPRL, Belgium.
[Ti] Título:miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats.
[So] Source:Toxicol Lett;286:31-38, 2018 Apr.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Investigation of genomic changes in cardiotoxicity can provide novel biomarkers and insights into molecular mechanisms of drug-induced cardiac injury (DICI). The main objective of this study was to identify and characterize dysregulated microRNAs (miRNAs) in the heart associated with cardiotoxicity. Wistar rats were dosed once with either isoproterenol (1.5 mg/kg, i.p), allylamine (100 mg/kg, p.o.) or the respective vehicle controls. Heart tissue was collected at 24 h, 48 h and 72 h post-drug administration and used for histopathological assessment, miRNA profiling, immunohistochemical analysis and in situ hybridization. Multiplex analysis of 68 miRNAs in the heart revealed a significant upregulation of several miRNAs (miR-19a-3p, miR-142-3p, miR-155-5p, miR-208b-3p, miR-21-5p) after isoproterenol and one miRNA (miR-21-5p) after allylamine administration. Localization of miR-21-5p was specific to inflammatory cell infiltrates in the heart after both treatments. Immunohistochemical analysis of Stat3, a known miR-21-5p regulator, also confirmed its upregulation in cardiomyocytes and inflammatory cell infiltrates. The toxicity signatures based on miRNA networks, identified in vivo, can potentially be used as mechanistic biomarkers as well as to study cardiotoxicity in vitro in order to develop sensitive tools for early hazard identification and risk assessment.
[Mh] Termos MeSH primário: Cardiopatias/induzido quimicamente
Inflamação/induzido quimicamente
MicroRNAs/genética
Miocárdio/metabolismo
[Mh] Termos MeSH secundário: Alilamina
Animais
Cardiotoxicidade
Modelos Animais de Doenças
Perfilação da Expressão Gênica/métodos
Regulação da Expressão Gênica
Marcadores Genéticos
Cardiopatias/genética
Cardiopatias/metabolismo
Cardiopatias/patologia
Hibridização In Situ
Inflamação/genética
Inflamação/metabolismo
Inflamação/patologia
Isoproterenol
Masculino
MicroRNAs/metabolismo
Reação em Cadeia da Polimerase Multiplex
Miocárdio/patologia
Análise de Sequência com Séries de Oligonucleotídeos
Ratos Wistar
Medição de Risco
Fator de Transcrição STAT3/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers); 0 (MicroRNAs); 0 (STAT3 Transcription Factor); 0 (Stat3 protein, rat); 0 (mirn21 microRNA, rat); 48G762T011 (Allylamine); L628TT009W (Isoproterenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


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[PMID]:28331124
[Au] Autor:Nakazawa A; Tang N; Inoue Y; Kamichatani W; Katoh T; Saito M; Obara K; Toriba A; Hayakawa K
[Ad] Endereço:Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
[Ti] Título:Evaluation of Adsorption Characteristics of a Fibrous Adsorbent Containing Zwitter-Ionic Functional Group, Targeting Organic Acids.
[So] Source:J UOEH;39(1):69-74, 2017.
[Is] ISSN:0387-821X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Diallylamine-maleic acid copolymer (DAM)-nonwoven fabric (DAM-f), a fibrous adsorbent, contains DAM with zwitter-ionic functional groups and forms a hydration layer on the surface. The aim of this report was to evaluate the adsorption selectivity of DAM-f to semi-volatile organic acid (C1-C5). In the aqueous phase, formic acid dissolved in the hydration layer bound to the imino group of DAM-f due to anion exchange interaction. In the gas phase, the adsorption amounts of organic acids increased with the exposure time. Moreover, the adsorption rate constants correlated with the air/water partition coefficients (log K ) for formic acid, propionic acid, butyric acid, valeric acid and isovaleric acid, except for acetic acid. These results indicate that DAM-f is highly selective to hydrophilic compounds which easily move from the air to the hydration layer of DAM-f.
[Mh] Termos MeSH primário: Ácido Acético
Ácido Butírico
Ácidos Pentanoicos
Propionatos
[Mh] Termos MeSH secundário: Adsorção
Ar
Alilamina/química
Ânions
Formiatos
Gases
Interações Hidrofóbicas e Hidrofílicas
Troca Iônica
Maleatos/química
Polímeros/química
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Formates); 0 (Gases); 0 (Maleates); 0 (Pentanoic Acids); 0 (Polymers); 0 (Propionates); 059QF0KO0R (Water); 0YIW783RG1 (formic acid); 107-92-6 (Butyric Acid); 1BR7X184L5 (isovaleric acid); 48G762T011 (Allylamine); 91XW058U2C (maleic acid); GZK92PJM7B (n-pentanoic acid); JHU490RVYR (propionic acid); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.7888/juoeh.39.69


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[PMID]:28182119
[Au] Autor:Yang HY; Niu LN; Sun JL; Huang XQ; Pei DD; Huang C; Tay FR
[Ad] Endereço:The State Key Laboratory Breeding Base of Basic Science of Stomatology, Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, People's Republic of China.
[Ti] Título:Biodegradable mesoporous delivery system for biomineralization precursors.
[So] Source:Int J Nanomedicine;12:839-854, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Scaffold supplements such as nanoparticles, components of the extracellular matrix, or growth factors have been incorporated in conventional scaffold materials to produce smart scaffolds for tissue engineering of damaged hard tissues. Due to increasing concerns on the clinical side effects of using large doses of recombinant bone-morphogenetic protein-2 in bone surgery, it is desirable to develop an alternative nanoscale scaffold supplement that is not only osteoinductive, but is also multifunctional in that it can perform other significant bone regenerative roles apart from stimulation of osteogenic differentiation. Because both amorphous calcium phosphate (ACP) and silica are osteoinductive, a biodegradable, nonfunctionalized, expanded-pore mesoporous silica nanoparticle carrier was developed for loading, storage, and sustained release of a novel, biosilicification-inspired, polyamine-stabilized liquid precursor phase of ACP for collagen biomineralization and for release of orthosilicic acid, both of which are conducive to bone growth. Positively charged poly(allylamine)-stabilized ACP (PAH-ACP) could be effectively loaded and released from nonfunctionalized expanded-pore mesoporous silica nanoparticles (pMSN). The PAH-ACP released from loaded pMSN still retained its ability to infiltrate and mineralize collagen fibrils. Complete degradation of pMSN occurred following unloading of their PAH-ACP cargo. Because PAH-ACP loaded pMSN possesses relatively low cytotoxicity to human bone marrow-derived mesenchymal stem cells, these nanoparticles may be blended with any osteoconductive scaffold with macro- and microporosities as a versatile scaffold supplement to enhance bone regeneration.
[Mh] Termos MeSH primário: Regeneração Óssea/efeitos dos fármacos
Fosfatos de Cálcio/farmacologia
Nanopartículas/química
Osteogênese/efeitos dos fármacos
Polímeros/química
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Alilamina/química
Animais
Materiais Biocompatíveis/química
Bovinos
Diferenciação Celular/efeitos dos fármacos
Colágeno/química
Seres Humanos
Nanopartículas/administração & dosagem
Ácido Silícico/análise
Engenharia Tecidual
Tecidos Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Calcium Phosphates); 0 (Polymers); 0 (amorphous calcium phosphate); 1343-98-2 (Silicic Acid); 48G762T011 (Allylamine); 7631-86-9 (Silicon Dioxide); 9007-34-5 (Collagen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S128792


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[PMID]:27904092
[Au] Autor:Takahashi S
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Tohoku University.
[Ti] Título:Development and Biosensor Applications of Novel Functional Electrodes.
[So] Source:Yakugaku Zasshi;136(12):1585-1590, 2016.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Phenylboronic acid (PBA) derivatives have been used as alternatives to enzymes in the development of sugar-sensitive systems because the optical and electrochemical properties of these derivatives are significantly modulated upon sugar binding. This article reviews the voltammetric properties of sugar sensors prepared using dithiobis (4-butyrylamino-m-phenylboronic acid) (DTBA-PBA)-modified electrodes and PBA-appended layer-by-layer film-modified electrodes. In addition, the redox properties of reduced graphene oxide (rGO)-modified glassy carbon electrodes (GCEs) are discussed. The surface of a gold electrode was modified with a monolayer of DTBA-PBA to prepare sugar-sensitive electrodes. The modified electrodes exhibited attenuated cyclic voltammograms for Fe(CN) in the presence of sugars at neutral pH as a result of their binding to DTBA-PBA on the electrode. Useful calibration curves were obtained for determining 3-300 mM D-glucose and 0.3-30 mM D-fructose. Similarly, gold electrodes coated with multilayer films composed of PBA-modified poly(allylamine hydrochloride) and carboxymethylcellulose exhibited a sugar-dependent response at neutral pH. The dynamic range of these modified electrodes was 0.1-300 mM for D-glucose and D-fructose. The surface of GCE was modified with rGO to evaluate the electrochemical response of the modified GCE to hydrogen peroxide (H O ). The rGO-modified electrodes exhibited significantly higher responses in the redox reactions of H O compared with the response of an unmodified GCE.
[Mh] Termos MeSH primário: Técnicas Biossensoriais
Eletrodos
[Mh] Termos MeSH secundário: Alilamina
Ácidos Borônicos
Calibragem
Carbono
Carboximetilcelulose Sódica
Frutose
Glucose
Ouro
Grafite
Peróxido de Hidrogênio/química
Concentração de Íons de Hidrogênio
Oxirredução
Compostos de Sulfidrila
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Boronic Acids); 0 (Sulfhydryl Compounds); 0 (dithiobis(4-butyrylamino-m-phenylboronic acid)); 30237-26-4 (Fructose); 48G762T011 (Allylamine); 7440-44-0 (Carbon); 7440-57-5 (Gold); 7782-42-5 (Graphite); BBX060AN9V (Hydrogen Peroxide); IY9XDZ35W2 (Glucose); K679OBS311 (Carboxymethylcellulose Sodium); L12H7B02G5 (benzeneboronic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


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[PMID]:27612809
[Au] Autor:Rebl H; Finke B; Schmidt J; Mohamad HS; Ihrke R; Helm CA; Nebe JB
[Ad] Endereço:Dept. of Cell Biology, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany. Electronic address: henrike.rebl@med.uni-rostock.de.
[Ti] Título:Accelerated cell-surface interlocking on plasma polymer-modified porous ceramics.
[So] Source:Mater Sci Eng C Mater Biol Appl;69:1116-24, 2016 Dec 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Excellent osseointegration of permanent implants is crucial for the long lasting success of the implantation. To improve the osseointegrative potential, bio-inert titanium alloy surfaces (Ti6Al4V) are modified by plasma chemical oxidation (PCO®) of the titanium-oxide layer to a non-stoichiometric, amorphous calcium phosphate layer. The native titanium-oxide film measuring only a few nanometers is converted by PCO® to a thick porous calcium phosphate layer of about 10µm. In a second step the PCO surface is combined with a cell adhesive plasma-polymerized allylamine (PPAAm) nano film (5 and 50nm). Independent of the PPAAm coating homogeneity, the human osteoblast-like MG-63 cells show a remarkable increase in cell size and well-developed filopodia. Analyses of the actin cytoskeleton reveal that the cells mold to the pore shape of the PPAAm-covered PCO, thereby establishing a strong attachment to the surface. Interestingly, we could demonstrate that even though our untreated PCO shows excellent hydrophilicity, this alone is not sufficient to facilitate fast cell spreading, but the positive surface charges mediated by PPAAm. This multilayer composite material guarantees enhanced interlocking of the cells with the porous surface.
[Mh] Termos MeSH primário: Cerâmica/química
Materiais Revestidos Biocompatíveis/química
Polímeros/química
[Mh] Termos MeSH secundário: Citoesqueleto de Actina/efeitos dos fármacos
Alilamina/química
Fosfatos de Cálcio/química
Adesão Celular/efeitos dos fármacos
Linhagem Celular
Materiais Revestidos Biocompatíveis/farmacologia
Seres Humanos
Microscopia Eletrônica de Varredura
Oxirredução
Espectroscopia Fotoeletrônica
Porosidade
Propriedades de Superfície
Titânio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Phosphates); 0 (Coated Materials, Biocompatible); 0 (Polymers); 0 (amorphous calcium phosphate); 12743-70-3 (titanium alloy (TiAl6V4)); 48G762T011 (Allylamine); D1JT611TNE (Titanium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE


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[PMID]:27574968
[Au] Autor:Mooranian A; Negrulj R; Al-Salami H
[Ad] Endereço:a Biotechnology and Drug Development Research Laboratory, School of Pharmacy , Curtin Health Innovation Research Institute, Curtin University , Perth , Western Australia , Australia.
[Ti] Título:The impact of allylamine-bile acid combinations on cell delivery microcapsules in diabetes.
[So] Source:J Microencapsul;33(6):569-574, 2016 Sep.
[Is] ISSN:1464-5246
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In a recent study, we developed a new microencapsulating method for ß-cell microencapsulation, but cell viability declined rapidly, post microencapsulation, due to potential polymer-polyelectrolyte chelation and non-porous microcapsules' membranes resulting in cell apoptosis. Thus, this study tested the effects of incorporating cationic polyamine at 1% w/v, on microcapsule strength and cell viability, in the absence or presence of an anionic tertiary bile acid (ATBA) with potential cell-protective effects. METHODS: 1% w/v polyamine was used without or with ATBA, to form ß-cell microcapsules and physical and biological analyses was carried out 50 h post microencapsulation. RESULTS: Microcapsules containing 1% w/v polyamine showed weak physical properties and low cell viability and ATBA incorporation resulted in >30% reduction in cell viability and increased levels of pro-inflammatory cytokines. CONCLUSION: Neither 1% w/v polyamine nor the presence of ATBA resulted in optimised cell viability, but rather reduced cell viability, enhanced inflammation and lowered insulin secretion.
[Mh] Termos MeSH primário: Alilamina
Ácidos e Sais Biliares
Diabetes Mellitus/tratamento farmacológico
Sistemas de Liberação de Medicamentos/métodos
Células Secretoras de Insulina/metabolismo
[Mh] Termos MeSH secundário: Alilamina/química
Alilamina/farmacocinética
Alilamina/farmacologia
Ácidos e Sais Biliares/química
Ácidos e Sais Biliares/farmacocinética
Ácidos e Sais Biliares/farmacologia
Cápsulas
Linhagem Celular
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Capsules); 48G762T011 (Allylamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE


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[PMID]:27495192
[Au] Autor:Jarnicki AG; Schilter H; Liu G; Wheeldon K; Essilfie AT; Foot JS; Yow TT; Jarolimek W; Hansbro PM
[Ad] Endereço:Centre for Asthma and Respiratory Disease, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, NSW, Australia.
[Ti] Título:The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model.
[So] Source:Br J Pharmacol;173(22):3161-3175, 2016 Nov.
[Is] ISSN:1476-5381
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Chronic obstructive pulmonary disease (COPD) is a major cause of illness and death, often induced by cigarette smoking (CS). It is characterized by pulmonary inflammation and fibrosis that impairs lung function. Existing treatments aim to control symptoms but have low efficacy, and there are no broadly effective treatments. A new potential target is the ectoenzyme, semicarbazide-sensitive mono-amine oxidase (SSAO; also known as vascular adhesion protein-1). SSAO is elevated in smokers' serum and is a pro-inflammatory enzyme facilitating adhesion and transmigration of leukocytes from the vasculature to sites of inflammation. EXPERIMENTAL APPROACH: PXS-4728A was developed as a low MW inhibitor of SSAO. A model of COPD induced by CS in mice reproduces key aspects of human COPD, including chronic airway inflammation, fibrosis and impaired lung function. This model was used to assess suppression of SSAO activity and amelioration of inflammation and other characteristic features of COPD. KEY RESULTS: Treatment with PXS-4728A completely inhibited lung and systemic SSAO activity induced by acute and chronic CS-exposure. Daily oral treatment inhibited airway inflammation (immune cell influx and inflammatory factors) induced by acute CS-exposure. Therapeutic treatment during chronic CS-exposure, when the key features of experimental COPD develop and progress, substantially suppressed inflammatory cell influx and fibrosis in the airways and improved lung function. CONCLUSIONS AND IMPLICATIONS: Treatment with a low MW inhibitor of SSAO, PXS-4728A, suppressed airway inflammation and fibrosis and improved lung function in experimental COPD, demonstrating the therapeutic potential of PXS-4728A for this debilitating disease.
[Mh] Termos MeSH primário: Alilamina/análogos & derivados
Amina Oxidase (contendo Cobre)/antagonistas & inibidores
Benzamidas/farmacologia
Inibidores Enzimáticos/farmacologia
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
[Mh] Termos MeSH secundário: Alilamina/farmacologia
Amina Oxidase (contendo Cobre)/metabolismo
Animais
Modelos Animais de Doenças
Feminino
Camundongos
Camundongos Endogâmicos C57BL
Doença Pulmonar Obstrutiva Crônica/enzimologia
Fumar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzamides); 0 (Enzyme Inhibitors); 0 (PXS-4728A); 48G762T011 (Allylamine); EC 1.4.3.21 (Amine Oxidase (Copper-Containing))
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE
[do] DOI:10.1111/bph.13573


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[PMID]:27455628
[Au] Autor:Ye Y; Xie H; Shao X; Wei Y; Liu Y; Zhao W; Xia X
[Ti] Título:Amperometric Glucose Biosensor Based on Effective Self-Assembly Technology for Preparation of Poly(allylamine hydrochloride)/Au Nanoparticles Multilayers.
[So] Source:J Nanosci Nanotechnol;16(3):2270-6, 2016 Mar.
[Is] ISSN:1533-4880
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Novel nanomaterials and nanotechnology for use in bioassay applications represent a rapidly advancing field. This study developed a novel method to fabricate the glucose biosensor with good gold nanoparticles (AuNPs) fixed efficiency based on effective self-assembly technology for preparation of multilayers composed of poly(allylamine hydrochloride) (PAH) and AuNPs. The electrochemical properties of the biosensor based on (AuNPs/PAH)n/AuNPs/glucose oxide (GOD) with different multilayers were systematically investigated. Among the resulting glucose biosensors, electrochemical properties of the biosensor with three times self-assembly processes ((AuNPs/PAH)3/AuNPs/GOD) is best. The GOD biosensor exhibited a fast amperometric response (5 s) to glucose, a good linear current-time relation over a wide range of glucose concentrations from 0.05 to 162 mM, and a low detection limit of 0.029 mM. The GOD biosensor modified with (AuNPs/PAH)n layers will have essential significance and practical application in future owing to the simple method of fabrication and good performance.
[Mh] Termos MeSH primário: Alilamina/química
Técnicas Biossensoriais
Glucose/análise
Ouro/química
Nanopartículas Metálicas
Polímeros/química
[Mh] Termos MeSH secundário: Técnicas Eletroquímicas
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polymers); 48G762T011 (Allylamine); 7440-57-5 (Gold); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE


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[PMID]:27450299
[Au] Autor:Kazemi Z; Rudbari HA; Sahihi M; Mirkhani V; Moghadam M; Tangestaninejad S; Mohammadpoor-Baltork I; Gharaghani S
[Ad] Endereço:Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran.
[Ti] Título:Synthesis, characterization and biological application of four novel metal-Schiff base complexes derived from allylamine and their interactions with human serum albumin: Experimental, molecular docking and ONIOM computational study.
[So] Source:J Photochem Photobiol B;162:448-462, 2016 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Novel metal-based drug candidate including VOL2, NiL2, CuL2 and PdL2 have been synthesized from 2-hydroxy-1-allyliminomethyl-naphthalen ligand and have been characterized by means of elemental analysis (CHN), FT-IR and UV-vis spectroscopies. In addition, (1)H and (13)C NMR techniques were employed for characterization of the PdL2 complex. Single-crystal X-ray diffraction technique was utilized to characterise the structure of the complexes. The Cu(II), Ni(II) and Pd(II) complexes show a square planar trans-coordination geometry, while in the VOL2, the vanadium center has a distorted tetragonal pyramidal N2O3 coordination sphere. The HSA-binding was also determined, using fluorescence quenching, UV-vis spectroscopy, and circular dichroism (CD) titration method. The obtained results revealed that the HSA affinity for binding the synthesized compounds follows as PdL2>CuL2>VOL2>NiL2, indicating the effect of metal ion on binding constant. The distance between these compounds and HSA was obtained based on the Förster's theory of non-radiative energy transfer. Furthermore, computational methods including molecular docking and our Own N-layered Integrated molecular Orbital and molecular Mechanics (ONIOM) were carried out to investigate the HSA-binding of the compounds. Molecular docking calculation indicated the existence of hydrogen bond between amino acid residues of HSA and all synthesized compounds. The formation of the hydrogen bond in the HSA-compound systems leads to their stabilization. The ONIOM method was utilized in order to investigate HSA binding of compounds more precisely in which molecular mechanics method (UFF) and semi empirical method (PM6) were selected for the low layer and the high layer, respectively. The results show that the structural parameters of the compounds changed along with binding to HSA, indicating the strong interaction between the compounds and HSA. The value of binding constant depends on the extent of the resultant changes. This should be mentioned that both theoretical methods calculated the Kb values in the same sequence and are in a good agreement with the experimental data.
[Mh] Termos MeSH primário: Alilamina/química
Simulação de Acoplamento Molecular
Compostos Organometálicos/química
Compostos Organometálicos/metabolismo
Albumina Sérica/química
Albumina Sérica/metabolismo
[Mh] Termos MeSH secundário: Transferência de Energia
Seres Humanos
Ligação Proteica
Conformação Proteica
Teoria Quântica
Bases de Schiff/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 0 (Schiff Bases); 0 (Serum Albumin); 48G762T011 (Allylamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27338326
[Au] Autor:Benedetti F; Berti F; Fanfoni L; Garbo M; Regini G; Felluga F
[Ad] Endereço:Department of Chemical and Pharmaceutical Sciences, University of Trieste, via Giorgieri 1. 34127 Trieste, Italy. benedett@units.it.
[Ti] Título:Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters.
[So] Source:Molecules;21(6), 2016 Jun 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral ß-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild conditions, with good yields, and without loss of stereochemical integrity, being in this respect superior to the conventional Julia reaction of α-amino aldehydes.
[Mh] Termos MeSH primário: Aldeídos/síntese química
Alilamina/síntese química
Éteres Metílicos/síntese química
[Mh] Termos MeSH secundário: Aldeídos/química
Alilamina/química
Aminoácidos/química
Cicloparafinas/química
Éteres Metílicos/química
Estrutura Molecular
Estereoisomerismo
Sulfonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 0 (Amino Acids); 0 (Cycloparaffins); 0 (Methyl Ethers); 0 (Sulfones); 48G762T011 (Allylamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE



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