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Pesquisa : D02.092.146.316 [Categoria DeCS]
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[PMID]:28040834
[Au] Autor:Shimamura M; Kurashige T; Mitsutake N; Nagayama Y
[Ad] Endereço:Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
[Ti] Título:Aldehyde dehydrogenase activity plays no functional role in stem cell-like properties in anaplastic thyroid cancer cell lines.
[So] Source:Endocrine;55(3):934-943, 2017 Mar.
[Is] ISSN:1559-0100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies have revealed that aldehyde dehydrogenase (ALDH) is a candidate marker for thyroid cancer stem cells, although its activity is flexible. The goal of this study is to clarify the functional significance of ALDH enzymatic activity on thyroid cancer stem cells properties in anaplastic thyroid cancer cell lines. In vitro sphere formation assay was used to judge the stemness of 4 anaplastic thyroid cancer cell lines (FRO, ACT1, 8505C, and KTC3). Two well-known ALDH inhibitors, N,N-diethylaminobenzaldehyde (DEAB) and disulfiram (DS), were first used. DEAB (50 µM) almost completely suppressed ALDH activity without affecting cell proliferation or spherogenicity. Lack of effect of ALDH suppression on spherogenicity was confirmed using shRNA for ALDH1A3, an ALDH isozyme predominantly expressed in anaplastic thyroid cancer cell lines. In contrast, an ALDH2 inhibitor DS (1 µM) inhibited spherogenicity but did not inhibit ALDH1A3 activity. Based on the recent article from another group reporting the importance of sonic hedgehog (Shh) signaling in ALDH activity and spherogenicity in thyroid cancer, the effects of the Shh inhibitor cyclopamine were also studied. Like DS, cyclopamine (1 µM) decreased spherogenicity but not ALDH activity. Finally, exogenous expression of ALDH1A3 in otherwise ALDH TPC1 cells (a papillary thyroid cancer cell line) revealed no effect on spherogenicity. In conclusion, we here show no functional role for ALDH activity in thyroid thyroid cancer stem cells properties. That is, ALDH activity and spherogenicity are clearly dissociable. Further understanding of thyroid cancer stem cells biology in thyroid cancers remains necessary for the future development of thyroid thyroid cancer stem cells-targeted therapies.
[Mh] Termos MeSH primário: Células-Tronco Neoplásicas/enzimologia
Carcinoma Anaplásico da Tireoide/enzimologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Dissulfiram/farmacologia
Seres Humanos
Células-Tronco Neoplásicas/efeitos dos fármacos
Células-Tronco Neoplásicas/patologia
Carcinoma Anaplásico da Tireoide/patologia
p-Aminoazobenzeno/análogos & derivados
p-Aminoazobenzeno/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2481-94-9 (C.I. Solvent Yellow 56); 57X2AH42T1 (p-Aminoazobenzene); TR3MLJ1UAI (Disulfiram)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE
[do] DOI:10.1007/s12020-016-1224-y


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[PMID]:27619487
[Au] Autor:Boglino A; Ponce M; Cousin X; Gisbert E; Manchado M
[Ad] Endereço:Centro de Investigación en Alimentación y Desarrollo, Unidad Mazatlán (CIAD), PO Box 711, 82010 Mazatlán, Sinaloa, Mexico.
[Ti] Título:Transcriptional regulation of genes involved in retinoic acid metabolism in Senegalese sole larvae.
[So] Source:Comp Biochem Physiol B Biochem Mol Biol;203:35-46, 2017 Jan.
[Is] ISSN:1879-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was the characterization of transcriptional regulatory pathways mediated by retinoic acid (RA) in Senegalese sole larvae. For this purpose, pre-metamorphic larvae were treated with a low concentration of DEAB, an inhibitor of RALDH enzyme, until the end of metamorphosis. No differences in growth, eye migration or survival were observed. Nevertheless, gene expression analysis revealed a total of 20 transcripts differentially expressed during larval development and only six related with DEAB treatments directly involved in RA metabolism and actions (rdh10a, aldh1a2, crbp1, igf2r, rarg and cyp26a1) to adapt to a low-RA environment. In a second experiment, post-metamorphic larvae were exposed to the all-trans RA (atRA) observing an opposite regulation for those genes involved in RA synthesis and degradation (rdh10a, aldh1a2, crbp1 and cyp26a1) as well as other related with thyroid- (dio2) and IGF-axes (igfbp1, igf2r and igfbp5) to balance RA levels. In a third experiment, DEAB-pretreated post-metamorphic larvae were exposed to atRA and TTNPB (a specific RAR agonist). Both drugs down-regulated rdh10a and aldh1a2 and up-regulated cyp26a1 expression demonstrating their important role in RA homeostasis. Moreover, five retinoic receptors that mediate RA actions, the thyroid receptor thrb, and five IGF binding proteins changed differentially their expression. Overall, this study demonstrates that exogenous RA modulates the expression of some genes involved in the RA synthesis, degradation and cellular transport through RAR-mediated regulatory pathways establishing a negative feedback regulatory mechanism necessary to balance endogenous RA levels and gradients.
[Mh] Termos MeSH primário: Linguados/genética
Linguados/metabolismo
Regulação da Expressão Gênica
Larva/genética
Larva/metabolismo
Tretinoína/metabolismo
[Mh] Termos MeSH secundário: Animais
Benzoatos/farmacologia
Regulação da Expressão Gênica/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Metamorfose Biológica/efeitos dos fármacos
Metamorfose Biológica/genética
Receptores do Ácido Retinoico/agonistas
Receptores do Ácido Retinoico/genética
Receptores do Ácido Retinoico/metabolismo
Retinoides/farmacologia
p-Aminoazobenzeno/análogos & derivados
p-Aminoazobenzeno/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoates); 0 (Receptors, Retinoic Acid); 0 (Retinoids); 2481-94-9 (C.I. Solvent Yellow 56); 5688UTC01R (Tretinoin); 57X2AH42T1 (p-Aminoazobenzene); 71441-28-6 (4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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[PMID]:27375233
[Au] Autor:Xiao D; Wang H; Han D
[Ad] Endereço:Third Institute of Oceanography, SOA, Xiamen 361005, China; School of Pharmaceutical Sciences Xiamen University, Xiamen 361102, China.
[Ti] Título:Single and combined genotoxicity effects of six pollutants on THP-1 cells.
[So] Source:Food Chem Toxicol;95:96-102, 2016 Sep.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the single and combined genotoxic effects of six food pollutants (Chrysoidine G, Sudan I, acid orange II, malachite green, acrylamide, and potassium bromate) on THP-1 cells through comet assay. The results of the single tests indicated that the pollutants increased the percentage of tail DNA (% tail DNA) in a dose-dependent manner. Moreover, the % tail DNA values induced by synthetic colorants (Chrysoidine G, Sudan I, acid orange II, and malachite green) were significantly higher than those by acrylamide or potassium bromate at most concentrations. In the combined tests, Chrysoidine G (422 µmol/L) or acrylamide (400 µmol/L) was mixed with different concentrations of the other five pollutants respectively. In the first combined tests, most mixtures significantly increased the % tail DNA values with the exception of Chrysoidine G and acid orange II. In the second tests, there were no significant differences in the % tail DNA values between the single and combined tests at most cases.
[Mh] Termos MeSH primário: Sobrevivência Celular/efeitos dos fármacos
Corantes/efeitos adversos
Dano ao DNA/efeitos dos fármacos
Poluentes Ambientais/efeitos adversos
Monócitos/efeitos dos fármacos
Testes de Mutagenicidade/métodos
Mutagênicos/efeitos adversos
[Mh] Termos MeSH secundário: Acrilamida/efeitos adversos
Compostos Azo/efeitos adversos
Bromatos/efeitos adversos
Carcinógenos/farmacologia
Sobrevivência Celular/genética
Células Cultivadas
Ensaio Cometa
Dano ao DNA/genética
Combinação de Medicamentos
Seres Humanos
Monócitos/metabolismo
Naftalenos/efeitos adversos
Naftóis/efeitos adversos
Corantes de Rosanilina/efeitos adversos
p-Aminoazobenzeno/efeitos adversos
p-Aminoazobenzeno/análogos & derivados
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acid Orange II); 0 (Azo Compounds); 0 (Bromates); 0 (Carcinogens); 0 (Coloring Agents); 0 (Drug Combinations); 0 (Environmental Pollutants); 0 (Mutagens); 0 (Naphthalenes); 0 (Naphthols); 0 (Rosaniline Dyes); 04MB35W6ZA (potassium bromate); 12058M7ORO (malachite green); 20R035KLCI (Acrylamide); 2431787HMZ (chrysoidine); 48I7IBB68J (1-phenylazo-2-naphthol); 57X2AH42T1 (p-Aminoazobenzene)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160705
[St] Status:MEDLINE


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[PMID]:26997588
[Au] Autor:Zhang L; Desta I; Naumov P
[Ad] Endereço:New York University Abu Dhabi, PO Box 129188, Abu Dhabi, United Arab Emirates. pance.naumov@nyu.edu.
[Ti] Título:Synergistic action of thermoresponsive and hygroresponsive elements elicits rapid and directional response of a bilayer actuator.
[So] Source:Chem Commun (Camb);52(35):5920-3, 2016 May 01.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A bilayer actuator composed of thermoresponsive and thermo/hygroresponsive elements is developed, which undergoes fast, directional and autonomous curling with a speed of up to 0.7 m s(-1) and recovers its shape by hydration. In situ tensile testing of the thermal response of individual layers provided insights into the mechanism of actuation of thermo/hygromorphic bilayers.
[Mh] Termos MeSH primário: Biomimética/métodos
Umidade
Movimento (Física)
Temperatura Ambiente
[Mh] Termos MeSH secundário: Álcool de Polivinil/química
Polivinil/química
Selaginellaceae
p-Aminoazobenzeno/análogos & derivados
p-Aminoazobenzeno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polyvinyls); 24937-79-9 (polyvinylidene fluoride); 41576-40-3 (4-aminoazotoluene); 57X2AH42T1 (p-Aminoazobenzene); 9002-89-5 (Polyvinyl Alcohol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160322
[St] Status:MEDLINE
[do] DOI:10.1039/c6cc01193d


  5 / 232 MEDLINE  
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[PMID]:26953730
[Au] Autor:Kang SM; Jang SC; Huh YS; Lee CS; Roh C
[Ad] Endereço:Biotechnology Research Division, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 29 Geumgu-gil, Jeongeup, Jeonbuk, 56212, South Korea; Department of Chemical Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, South Kor
[Ti] Título:A highly facile and selective Chemo-Paper-Sensor (CPS) for detection of strontium.
[So] Source:Chemosphere;152:39-46, 2016 Jun.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemosensors have attracted increasing attention for their usefulness on-site detection and monitoring. In this study, we elucidated a novel, facile, and highly selective Chemo-Paper-Sensor (CPS) for detection and monitoring of strontium (Sr(2+)) ions, which means a potent colorimetric sensor based on a Chrysoidine G (CG)-coated paper strip. The CPS for highly selective colorimetric detection of strontium ion was handily analyzed to determine the red-green-blue (RGB) value using portable devices such as desktop digital scanner and mobile phone camera, quantitatively. Interestingly, an orange to dark orange color transition was observed when the aqueous and solid paper colorimetric sensor was introduced to Sr(2+) ion, respectively. It was demonstrated that the value of the signal has a linear relationship with concentrations of the strontium in the 500 ppm to 100 ppb range with a detection limit of 200 ppb. We believe that a newly developed Chemo-Paper-Sensor will be useful in a wide range of sensing applications.
[Mh] Termos MeSH primário: Estrôncio/análise
p-Aminoazobenzeno/análogos & derivados
[Mh] Termos MeSH secundário: Colorimetria
Íons
Limite de Detecção
Papel
Estrôncio/química
Água
p-Aminoazobenzeno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ions); 059QF0KO0R (Water); 2431787HMZ (chrysoidine); 57X2AH42T1 (p-Aminoazobenzene); YZS2RPE8LE (Strontium)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE


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[PMID]:26433339
[Au] Autor:Duan H; Li L; Wang X; Wang Y; Li J; Luo C
[Ad] Endereço:Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China.
[Ti] Título:CdTe quantum dots@luminol as signal amplification system for chrysoidine with chemiluminescence-chitosan/graphene oxide-magnetite-molecularly imprinting sensor.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;153:535-41, 2016 Jan 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A sensitive chemiluminescence (CL) sensor based on chemiluminescence resonance energy transfer (CRET) in CdTe quantum dots@luminol (CdTe QDs@luminol) nanomaterials combined with chitosan/graphene oxide-magnetite-molecularly imprinted polymer (Cs/GM-MIP) for sensing chrysoidine was developed. CdTe QDs@luminol was designed to not only amplify the signal of CL but also reduce luminol consumption in the detection of chrysoidine. On the basis of the abundant hydroxy and amino, Cs and graphene oxide were introduced into the GM-MIP to improve the adsorption ability. The adsorption capacities of chrysoidine by both Cs/GM-MIP and non-imprinted polymer (Cs/GM-NIP) were investigated, and the CdTe QDs@luminol and Cs/GM-MIP were characterized by UV-vis, FTIR, SEM and TEM. The proposed sensor can detect chrysoidine within a linear range of 1.0×10(-7) - 1.0×10(-5) mol/L with a detection limit of 3.2×10(-8) mol/L (3δ) due to considerable chemiluminescence signal enhancement of the CdTe quantum dots@luminol detector and the high selectivity of the Cs/GM-MIP system. Under the optimal conditions of CL, the CdTe QDs@luminol-Cs/GM-MIP-CL sensor was used for chrysoidine determination in samples with satisfactory recoveries in the range of 90-107%.
[Mh] Termos MeSH primário: Compostos de Cádmio/química
Quitosana/química
Grafite/química
Medições Luminescentes/métodos
Luminol/química
Impressão Molecular/instrumentação
Pontos Quânticos/química
Telúrio/química
p-Aminoazobenzeno/análogos & derivados
[Mh] Termos MeSH secundário: Adsorção
Óxido Ferroso-Férrico/química
Transferência Ressonante de Energia de Fluorescência
Óxidos/química
Pontos Quânticos/ultraestrutura
Espectrometria de Fluorescência
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
p-Aminoazobenzeno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cadmium Compounds); 0 (Oxides); 2431787HMZ (chrysoidine); 57X2AH42T1 (p-Aminoazobenzene); 5EXP385Q4F (Luminol); 7782-42-5 (Graphite); 9012-76-4 (Chitosan); NQA0O090ZJ (Tellurium); STG188WO13 (cadmium telluride); XM0M87F357 (Ferrosoferric Oxide)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151005
[St] Status:MEDLINE


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[PMID]:26179104
[Au] Autor:Sun H; Liu Y; Li M; Han S; Yang X; Liu R
[Ad] Endereço:School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 27# Shanda South Road, Jinan, 250100, Peoples Republic of China.
[Ti] Título:Toxic effects of chrysoidine on human serum albumin: isothermal titration calorimetry and spectroscopic investigations.
[So] Source:Luminescence;31(2):335-40, 2016 Mar.
[Is] ISSN:1522-7243
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chrysoidine is widely used in industry as a type of azo dye, and is sometimes used illegally as a food additive despite its potential toxicity. Human serum albumin (HSA) is one of the most important proteins in blood plasma and possesses major physiological functions. In the present study, the conformational and functional effects of chrysoidine on HSA were investigated by isothermal titration calorimetry (ITC), multiple spectroscopic methods, a molecular docking study and an esterase activity assay. Based on the ITC results, the binding stoichiometry of chrysoidine to HSA was estimated to be 1.5:1, and was a spontaneous process via a single hydrogen bond. The binding of chrysoidine to HSA induced dynamic quenching in fluorescence, and changes in secondary structure and in the microenvironment of the Trp-214 residue. In addition, the hydrogen bond (1.80 Å) formed between the chrysoidine molecule and the Gln-211 residue. The esterase activity of HSA decreased following the addition chrysoidine due to the change in protein structure. This study details the direct interaction between chrysoidine and HSA at the molecular level and the mechanism for toxicity as a result of the functional changes induced by HSA structural variation upon binding to chrysoidine in vitro. This study provides useful information towards detailing the transportation mechanism and toxicity of chrysoidine in vivo.
[Mh] Termos MeSH primário: Calorimetria
Albumina Sérica/metabolismo
p-Aminoazobenzeno/análogos & derivados
[Mh] Termos MeSH secundário: Esterases/química
Esterases/metabolismo
Fluorescência
Seres Humanos
Ligações de Hidrogênio
Simulação de Acoplamento Molecular
Estrutura Molecular
Conformação Proteica/efeitos dos fármacos
Albumina Sérica/química
Espectrometria de Fluorescência
Espectrofotometria Ultravioleta
p-Aminoazobenzeno/química
p-Aminoazobenzeno/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Serum Albumin); 2431787HMZ (chrysoidine); 57X2AH42T1 (p-Aminoazobenzene); EC 3.1.- (Esterases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150717
[St] Status:MEDLINE
[do] DOI:10.1002/bio.2964


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[PMID]:26978915
[Au] Autor:Xu XQ; Liu QH; Yang F; Qian J; Chen J; Lin ZY; Qiu B
[Ti] Título:[Preparation of Gold Nano-Particles as Surface-Enhanced Raman Scattering Sensors for Analysis of Banned Food Dye Chrysoidin in Yuba].
[So] Source:Guang Pu Xue Yu Guang Pu Fen Xi;35(11):3092-5, 2015 Nov.
[Is] ISSN:1000-0593
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Chrysoidin is a kind of banned food dye, and it has been illegally used for coloring food. A rapid detection and quantification method is developed and applied in analysis chrysoidin in yuba. Gold nanoparticles are synthesized by using hexadecyl trimethyl ammonium bromide (CTAB) as the bifunctional ligand to link the solid substrate and the AuNPs. The laser wavelength used for quantitative is 1594 cm⁻¹. Significant differences between different concentrations of chrysoidin are verified by multiple variable analysis. A relationship between the logarithm of the concentrations and the intensity of laser is proved using univariate analysis method. The calibration curves showed good linearity in the range of 0.001-0.5 mmol · L⁻¹ with correlation coefficients r = 0.995. The method is successfully applied to the determination of chrysoidin in yuba. The average recoveries of the drugs spiked at 50 and 500 µg · g⁻¹ levels are 82.4% and 116.9%, and the relative standard deviations (RSD) are 3.8% and 4.0%. The method is simple, rapid, sensitive and accurate in the determination of chrysoidin.
[Mh] Termos MeSH primário: Corantes de Alimentos/análise
Ouro/química
Nanopartículas Metálicas/química
p-Aminoazobenzeno/análogos & derivados
[Mh] Termos MeSH secundário: Análise Espectral Raman
p-Aminoazobenzeno/análise
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Coloring Agents); 2431787HMZ (chrysoidine); 57X2AH42T1 (p-Aminoazobenzene); 7440-57-5 (Gold)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160316
[Lr] Data última revisão:
160316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE


  9 / 232 MEDLINE  
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[PMID]:26591610
[Au] Autor:Frolova TS; Sinitsyna OI; Kaledin VI
[Ti] Título:[Mutagenic Activity of Four Aminoazo Compounds with Different Carcinogenicity for Rat Liver in the Ames Test].
[So] Source:Biofizika;60(5):990-4, 2015 Sep-Oct.
[Is] ISSN:0006-3029
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In this paper in the bacterial Ames test we compared the mutagenicity of four aminoazo compounds, previously studied by other researchers and used for activation of rat liver enzymes, with the carcinogenicity in the rat liver. It was found that in the Ames test they have mutagenic activity, however, this activity does not correlate quantitatively with rat sensitivity to their hepatocarcinogenic action. Thus, the most active carcinogen 3'-methyl-4-dimethylaminoazobenzene causes mutations almost 2.5 times less than weakly carcinogenic ortho-aminoazotoluene, and exactly the same number of mutations as non-carcinogenic N,N-diethyl-4-aminoazobenzene.
[Mh] Termos MeSH primário: Compostos Azo/toxicidade
Carcinógenos/toxicidade
Mutagênicos/toxicidade
Salmonella typhimurium/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Fígado/efeitos dos fármacos
Fígado/patologia
Metildimetilaminoazobenzeno/toxicidade
Mutação/efeitos dos fármacos
Ratos
p-Aminoazobenzeno/análogos & derivados
p-Aminoazobenzeno/toxicidade
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Carcinogens); 0 (Mutagens); 2481-94-9 (C.I. Solvent Yellow 56); 55-80-1 (Methyldimethylaminoazobenzene); 57X2AH42T1 (p-Aminoazobenzene); F0U1H6UG5C (azobenzene)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:151120
[Lr] Data última revisão:
151120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE


  10 / 232 MEDLINE  
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Fotocópia
[PMID]:26415378
[Au] Autor:Guliy OI; Bunin VD; Larionova OS; Potemkina EG; Ignatov OV
[Ti] Título:[Determination of Microbial Susceptibility to Sulfanilamides by Electrooptic Analysis].
[So] Source:Antibiot Khimioter;60(3-4):14-9, 2015.
[Is] ISSN:0235-2990
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The effect of sulfanilamides (soluble streptocid as an example) on changing of the electrophysical properties (EP) of microbial cells of Escherichia coli XL-1, BL-Ril, Pseudomonasputida C-11 and BA-11 was studied. It was shown that significant changes in the orientation spectra (OS) of the cell suspensions incubated at various concentrations of the sulfanilamide resulted in changing of the electrooptic (EO) signal of the cell suspension at the first five frequencies of the orientation electric field (10-1000 Hz) with the use of soluble streptocid in a concentration of 0.3 mcg/ml. The dynamics of the drug effect on the microbial cells demonstrated a decrease of the EO signal value 5 minutes after the exposure by -59% vs. the control (the cells not exposed to the drug). During the following exposure the EO signal value practically did not change (within 5%). The changes of the OS of the cell suspensions exposed to soluble streptocid significantly differed for the susceptible and resistant strains. Determination of the activity of sulfanilamides by electrooptic analysis of microbial cell suspensions was considered possible. Changing of the microbial suspencion OS under the effect of sulfanilamides can be used as a test on the microbial cell susceptibility to drugs.
[Mh] Termos MeSH primário: Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana/métodos
Pseudomonas putida/efeitos dos fármacos
Sulfanilamidas/farmacologia
p-Aminoazobenzeno/análogos & derivados
[Mh] Termos MeSH secundário: Impedância Elétrica
Escherichia coli/crescimento & desenvolvimento
Testes de Sensibilidade Microbiana/instrumentação
Dispositivos Ópticos
Pseudomonas putida/crescimento & desenvolvimento
Solubilidade
p-Aminoazobenzeno/farmacologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfanilamides); 57X2AH42T1 (p-Aminoazobenzene); Q64Q9N6Q6O (sulfamidochrysoidine)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150930
[St] Status:MEDLINE



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