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[PMID]:29180287
[Au] Autor:Hein DW; Zhang X; Doll MA
[Ad] Endereço:Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY USA. Electronic address: d.hein@louisville.edu.
[Ti] Título:Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.
[So] Source:Toxicol Lett;283:100-105, 2018 Feb.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the acetylation of arylamine carcinogens. Single nucleotide polymorphisms in the NAT2 coding exon present in NAT2 haplotypes encode allozymes with reduced N-acetyltransferase activity towards the N-acetylation of arylamine carcinogens and the O-acetylation of their N-hydroxylated metabolites. NAT2 acetylator phenotype modifies urinary bladder cancer risk following exposures to arylamine carcinogens such as 4-aminobiphenyl. 4, 4'-methylene bis (2-chloroaniline) (MOCA) is a Group 1 carcinogen for which a role of the NAT2 acetylation polymorphism on cancer risk is unknown. We investigated the role of NAT2 and the genetic acetylation polymorphism on both MOCA N-acetylation and N-hydroxy-MOCA O-acetylation. MOCA N-acetylation exhibited a robust gene dose response in rabbit liver cytosol and in cryopreserved human hepatocytes derived from individuals of rapid, intermediate and slow acetylator NAT2 genotype. MOCA exhibited about 4-fold higher affinity for recombinant human NAT2 than NAT1. Recombinant human NAT2*4 (reference) and 15 variant recombinant human NAT2 allozymes catalyzed both the N-acetylation of MOCA and the O-acetylation of N-hydroxy-MOCA. Human NAT2 5, NAT2 6, NAT2 7 and NAT2 14 allozymes catalyzed MOCA N-acetylation and N-hydroxy-O-acetylation at rates much lower than the reference NAT2 4 allozyme. In conclusion, our results show that NAT2 acetylator genotype has an important role in MOCA metabolism and suggest that risk assessments related to MOCA exposures consider accounting for NAT2 acetylator phenotype in the analysis.
[Mh] Termos MeSH primário: Arilamina N-Acetiltransferase/genética
Arilamina N-Acetiltransferase/metabolismo
Carcinógenos/metabolismo
Metilenobis (cloroanilina)/metabolismo
[Mh] Termos MeSH secundário: Acetilação
Animais
Biotransformação
Citosol/metabolismo
Hepatócitos/enzimologia
Hepatócitos/metabolismo
Seres Humanos
Isoenzimas/genética
Isoenzimas/metabolismo
Polimorfismo Genético
Coelhos
Proteínas Recombinantes
Neoplasias da Bexiga Urinária/induzido quimicamente
Neoplasias da Bexiga Urinária/genética
Neoplasias da Bexiga Urinária/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Isoenzymes); 0 (Recombinant Proteins); 3L2W5VTT2A (Methylenebis(chloroaniline)); EC 2.3.1.5 (Arylamine N-Acetyltransferase); EC 2.3.1.5 (NAT2 protein, human)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:27679675
[Au] Autor:Wang CC; Chen WL; Hsiung CN; Chiang ST; Wang YC; Loh CH; Lin IS; Chen HI; Liou SH
[Ad] Endereço:Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
[Ti] Título:Effect of CYP3A4 genetic polymorphisms on the genotoxicity of 4,4'-methylene-bis(2-chloroaniline)-exposed workers.
[So] Source:Occup Environ Med;74(1):30-38, 2017 Jan.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We investigated the relationship between 4,4'-methylene-bis(2-chloroaniline) (MBOCA) exposure and micronucleus (MN) frequency, and how this association was affected by genetic polymorphism of the cytochrome P450 enzyme (CYP3A4). METHODS: We divided the study population into an exposed group (n=44 with total urine MBOCA ≥20 µg/g creatinine) and a control group (n=47 with total urine MBOCA <20 µg/g creatinine). Lymphocyte MN frequency (MNF) and micronucleated cell (MNC) frequency were measured by the cytokinesis-block MN assay method. MNF reported as the number of micronuclei in binucleated cells per 1000 cells, and MNC reported as the number of binucleated cells with the presence of MN per 1000 cells. CYP3A4 alleles were measured by PCR-based restriction fragment length polymorphism (PCR-RFLP). RESULTS: The mean MNF (6.11 vs 4.46 MN/1000 cells, p<0.001) and MNC (5.75 vs 4.15 MN/1000 cells, p<0.001) in the exposed workers was significantly higher than that in the controls. The CYP3A4 polymorphism A/A+A/G influenced the difference in the mean MNF (5.97 vs 4.38 MN/1000 cells, p<0.001) and MNC (5.60 vs 4.15 MN/1000 cells, p<0.001) between the MBOCA-exposed and control groups. After adjusting risk factors, the MNF level in the MBOCA-exposed workers was 0.520 MN cells/1000 cells (p<0.001) higher than the control group among the CYP3A4 A/A+A/G genotype. Similarly, the MNC level in the MBOCA-exposed workers was 0.593 MN/1000 cells (p<0.001) higher than the control group among the CYP3A4 A/A+A/G genotype. However, the difference in adjusted MNF and MNC between the exposed and control groups was not significant for the CYP3A4 polymorphism with the G/G genotype. CONCLUSIONS: We recommend that lymphocytes MNF and MNC are good indicators to evaluate MBOCA genotoxicity. Individuals with the CYP3A4 polymorphism A/A and A/G genotypes appear to be more susceptible to MBOCA genotoxicity.
[Mh] Termos MeSH primário: Compostos de Anilina/efeitos adversos
Citocromo P-450 CYP3A/genética
Metilenobis (cloroanilina)/efeitos adversos
Exposição Ocupacional/efeitos adversos
Polimorfismo Genético
[Mh] Termos MeSH secundário: Adulto
Consumo de Bebidas Alcoólicas/epidemiologia
Análise de Variância
Compostos de Anilina/urina
Índice de Massa Corporal
Citocromo P-450 CYP3A/sangue
Citocromo P-450 CYP3A/urina
Sistema Enzimático do Citocromo P-450
Feminino
Genótipo
Seres Humanos
Linfócitos/química
Masculino
Metilenobis (cloroanilina)/análise
Meia-Idade
Testes de Mutagenicidade
Reação em Cadeia da Polimerase
Fatores de Risco
Fumar/epidemiologia
Taiwan/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 3L2W5VTT2A (Methylenebis(chloroaniline)); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.14.13.67 (CYP3A4 protein, human); EC 1.14.14.1 (Cytochrome P-450 CYP3A); G14I494T2F (2-chloroaniline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160929
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-103816


  3 / 111 MEDLINE  
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[PMID]:25069897
[Au] Autor:Takeuchi A; Namera A; Sakui N; Yamamuro K; Kawai T; Sumino K
[Ad] Endereço:Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association.
[Ti] Título:A method for routine analysis of urinary 4,4'-methylenebis (2-chloroaniline) by gas chromatography-electron capture detection.
[So] Source:J Occup Health;56(5):347-50, 2014.
[Is] ISSN:1348-9585
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of this study was to develop a simple and cost-effective method for the determination of urinary 4,4'-methylenebis (2-chloroaniline) (MBOCA) by gas chromatography-electron capture detection (GC-ECD) for biological monitoring of occupational exposure to MBOCA. METHODS: MBOCA was prepared by liquid-liquid extraction after alkaline hydrolysis, derivatized with N-methyl-bis (trifluoroacetamide) and then analyzed using GC-ECD. The proposed method was validated in accordance with the US Food and Drug Administration guidance. RESULTS: The calibration curve showed linearity in the range 1-100 µg/l, with a correlation coefficient of >0.999. The limits of detection and quantification were 0.3 µg/l and 1 µg/l, respectively. The recovery was 94-99%. Intraday accuracy, expressed as the deviation from the nominal value, was 90.5-100.3%, and intraday precision, expressed as the relative standard deviation, was 0.3-2.4%. Interday accuracy and precision were 87.8-100.2% and 0.3-4.1%, respectively. CONCLUSIONS: The proposed method is a simple and cost-effective method suitable for routine analyses and could be useful for biological monitoring of occupational exposure to MBOCA.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/urina
Monitoramento Ambiental/métodos
Metilenobis (cloroanilina)/análise
Metilenobis (cloroanilina)/metabolismo
Exposição Ocupacional/análise
Urina/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 3L2W5VTT2A (Methylenebis(chloroaniline))
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141125
[Lr] Data última revisão:
141125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140730
[St] Status:MEDLINE


  4 / 111 MEDLINE  
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[PMID]:23712675
[Au] Autor:Sheshenev AE; Boltukhina EV; White AJ; Hii KK
[Ad] Endereço:Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.
[Ti] Título:Methylene-bridged bis(imidazoline)-derived 2-oxopyrimidinium salts as catalysts for asymmetric Michael reactions.
[So] Source:Angew Chem Int Ed Engl;52(27):6988-91, 2013 Jul 01.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Imidazolinas/química
Metilenobis (cloroanilina)/química
[Mh] Termos MeSH secundário: Catálise
Modelos Moleculares
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Imidazolines); 3L2W5VTT2A (Methylenebis(chloroaniline))
[Em] Mês de entrada:1404
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130529
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201300614


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[PMID]:23491024
[Au] Autor:Lin IS; Fan PL; Chen HI; Loh CH; Shih TS; Liou SH
[Ad] Endereço:Department of Family Medicine & Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Neihu, Taipei, Taiwan, ROC.
[Ti] Título:Rapid and intermediate N-acetylators are less susceptible to oxidative damage among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.
[So] Source:Int J Hyg Environ Health;216(4):515-20, 2013 Jul.
[Is] ISSN:1618-131X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: In this study, we explored the association between a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), and genetic polymorphism of the carcinogen-metabolizing enzyme N-acetyltransferase 2 (NAT2) among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers. METHODS: The study population was recruited from four MBOCA-producing factories, and included 57 MBOCA-exposed workers and 101 unexposed control workers. Personal characteristics were collected by questionnaire. Plasma 8-OHdG levels were measured by LC/MS/MS. NAT2 alleles were measured by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). RESULTS: NAT2 polymorphism influenced the plasma 8-OHdG levels of MBOCA-exposed workers, but not of non-exposed workers. No difference between exposed and control groups was found for the crude 8-OHdG levels among rapid, intermediate, and slow acetylators. After adjusting for gender, age, smoking, and alcohol consumption habit, the 8-OHdG concentration in the MBOCA-exposed workers was 0.18pg/ml (95% CI -1.80 to -0.12) lower than the control group among rapid and intermediate acetylators. However, the difference between exposed and control groups was not significant for slow acetylators. CONCLUSION: Gene-environment interactions could play a role in the carcinogenesis of occupational MBOCA exposure. We suggest that the impact of the NAT2 acetylator status is low, if at all, on the generation of the oxidative stress marker 8-OHdG in the investigated exposed group.
[Mh] Termos MeSH primário: Arilamina N-Acetiltransferase/genética
Desoxiguanosina/análogos & derivados
Metilenobis (cloroanilina)/metabolismo
Exposição Ocupacional/análise
[Mh] Termos MeSH secundário: Acetilação
Adulto
Arilamina N-Acetiltransferase/metabolismo
Desoxiguanosina/sangue
Feminino
Interação Gene-Ambiente
Genótipo
Seres Humanos
Masculino
Estresse Oxidativo
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3L2W5VTT2A (Methylenebis(chloroaniline)); 88847-89-6 (8-oxo-7-hydrodeoxyguanosine); EC 2.3.1.5 (Arylamine N-Acetyltransferase); EC 2.3.1.5 (NAT2 protein, human); G9481N71RO (Deoxyguanosine)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130517
[Lr] Data última revisão:
130517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130316
[St] Status:MEDLINE


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[PMID]:22483886
[Au] Autor:Buszewski B; Olszowy P; Szultka M; Jezewska A
[Ad] Endereço:Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7 Street, 87-100 Torun, Poland. bbusz@chem.uni.torun.pl
[Ti] Título:New approaches to extraction techniques in determination of 4,4'-methylenebis(2-chloroaniline) in air and water solutions.
[So] Source:Talanta;93:117-21, 2012 May 15.
[Is] ISSN:1873-3573
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Extraction techniques for 4,4'-methylenebis(2-chloroaniline) (MOCA) in air samples and water solutions were developed and compared. Classic techniques for air sampling of MOCA were enhanced by incorporating a derivatization step (3,5-dinitrobenzoyl chloride solution in toluene), thus increasing the limit of detection and limit of quantification. Sampling of MOCA from water solution was performed using novel nanoporous polymeric (polypyrrole and polythiophene) fiber coatings and solid phase microextraction. Samples were analyzed by high-performance liquid chromatography coupled with a UV detector. Using the modified method for air sampling of MOCA, we found that the limit of detection was 7.90 ng m(-3) and the limit of quantification was 23.8 ng m(-3). In contrast, the limit of detection for MOCA in water samples was 11.26 ng mL(-1) (polypyrrole) and 84.62 ng mL(-1) (polythiophene) and the limit of quantification for MOCA was from 33.78 (polypyrrole) and 253.86 ng mL(-1) (polythiophene). Correlation coefficients were 0.9997 for air and 0.8790-0.9852 for water samples, respectively. The techniques presented provide alternative methods for the determination of MOCA in air samples and in water solutions that are more sensitive, quicker and less expensive than previously established procedures.
[Mh] Termos MeSH primário: Ar/análise
Metilenobis (cloroanilina)/análise
Metilenobis (cloroanilina)/isolamento & purificação
Microextração em Fase Sólida/métodos
Água/química
[Mh] Termos MeSH secundário: Polímeros/química
Pirróis/química
Soluções
Solventes/química
Tiofenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polymers); 0 (Pyrroles); 0 (Solutions); 0 (Solvents); 0 (Thiophenes); 059QF0KO0R (Water); 25233-34-5 (polythiophene); 30604-81-0 (polypyrrole); 3L2W5VTT2A (Methylenebis(chloroaniline))
[Em] Mês de entrada:1208
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120410
[St] Status:MEDLINE
[do] DOI:10.1016/j.talanta.2012.01.057


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[PMID]:21501672
[Au] Autor:Keen C; Coldwell M; McNally K; Baldwin P; McAlinden J; Cocker J
[Ad] Endereço:Health & Safety Laboratory, Harpur Hill Buxton SK17 9JN, UK.
[Ti] Título:A follow up study of occupational exposure to 4,4'-methylene-bis(2-chloroaniline) (MbOCA) and isocyanates in polyurethane manufacture in the UK.
[So] Source:Toxicol Lett;213(1):3-8, 2012 Aug 13.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This is a follow up survey of exposure to 4,4'-methylene-bis(2-chloroaniline) (MbOCA) and isocyanates in the UK polyurethane industry. Urine samples (n=446) were collected from 90 different workers. MbOCA levels were below the limit of detection in 170 samples and 26 were above the UK Biological Monitoring Guidance Value (BMGV) of 15 µmol MbOCA/mol creatinine. Detailed advice and guidance was given to each workplace at the end of the survey in 2008 and the 90% value reduced from 10 to 3 µmol MbOCA/mol creatinine in samples collected since. There was a positive correlation between glove contamination and urinary MbOCA and levels were dependent upon individual working practices especially how gloves were used. Of the 446 samples analysed for urinary metabolites of toluene diisocyanate 280 were below the detection limit and 126 were above the BMGV (1 µmol/mol creatinine). Of the 326 urine samples that were analysed for metabolites of methylenediphenyl diisocyanate, 270 were below the detection limit and 13 were above the BMGV for isocyanates. There was no correlation between urinary levels of isocyanates and MbOCA suggesting different routes of absorption, most likely inhalation and dermal respectively.
[Mh] Termos MeSH primário: Indústria Química
Isocianatos/urina
Metilenobis (cloroanilina)/análise
Exposição Ocupacional
Poliuretanos/síntese química
[Mh] Termos MeSH secundário: Creatinina/urina
Seguimentos
Luvas Protetoras
Seres Humanos
Exposição por Inalação
Concentração Máxima Permitida
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Isocyanates); 0 (Polyurethanes); 3L2W5VTT2A (Methylenebis(chloroaniline)); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110420
[St] Status:MEDLINE
[do] DOI:10.1016/j.toxlet.2011.04.003


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[PMID]:21860478
[Au] Autor:National Toxicology Program
[Ti] Título:4,4'-Methylenebis(2-chloroaniline).
[So] Source:Rep Carcinog;12:262-4, 2011.
[Is] ISSN:1551-8280
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinógenos Ambientais/envenenamento
Metilenobis (cloroanilina)/envenenamento
[Mh] Termos MeSH secundário: Animais
Testes de Carcinogenicidade
Carcinógenos Ambientais/química
Carcinógenos Ambientais/toxicidade
Exposição Ambiental/efeitos adversos
Exposição Ambiental/legislação & jurisprudência
Exposição Ambiental/normas
Regulamentação Governamental
Guias como Assunto
Seres Humanos
Metilenobis (cloroanilina)/química
Metilenobis (cloroanilina)/toxicidade
Camundongos
Estrutura Molecular
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/legislação & jurisprudência
Exposição Ocupacional/normas
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens, Environmental); 3L2W5VTT2A (Methylenebis(chloroaniline))
[Em] Mês de entrada:1201
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110824
[St] Status:MEDLINE


  9 / 111 MEDLINE  
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[PMID]:21473712
[Au] Autor:Jezewska A; Buszewski B
[Ad] Endereço:Central Institute for Labour Protection-National Research Institute, Warszawa, Poland.
[Ti] Título:A new method for the determination of 2,2'-dichloro-4,4'-methylenedianiline in workplace air samples by HPLC-DAD.
[So] Source:Toxicol Mech Methods;21(7):554-60, 2011 Sep.
[Is] ISSN:1537-6524
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new procedure has been developed for the assay of 2,2'-dichloro-4,4'-methylenedianiline (MOCA) using high-performance liquid chromatography with diode array detector. MOCA was sampled from workplace air and derivative before determination using 3,5-dinitrobenzoyl chloride. The determination was carried out in the reverse-phase system (mobile phase: acetonitrile: water) using an Ultra C(18) column. The measurement range was 2-40 µg/m(3) for a 100 dm(3) air sample. Limit of detection: 7.9 ng/m(3) and limit of quantification: 23.8 ng/m(3).
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise
Ar/normas
Cromatografia Líquida de Alta Pressão/métodos
Monitoramento Ambiental/métodos
Metilenobis (cloroanilina)/análise
Local de Trabalho/normas
[Mh] Termos MeSH secundário: Ar/análise
Calibragem
Cromatografia Líquida de Alta Pressão/instrumentação
Monitoramento Ambiental/instrumentação
Limite de Detecção
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 3L2W5VTT2A (Methylenebis(chloroaniline))
[Em] Mês de entrada:1112
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110409
[St] Status:MEDLINE
[do] DOI:10.3109/15376516.2011.571726


  10 / 111 MEDLINE  
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[PMID]:19564173
[Au] Autor:Dost A; Straughan JK; Sorahan T
[Ad] Endereço:British Rubber and Polyurethane Products Association Limited, London, UK. adost@brppa.co.uk
[Ti] Título:Cancer incidence and exposure to 4,4'-methylene-bis-ortho-chloroaniline (MbOCA).
[So] Source:Occup Med (Lond);59(6):402-5, 2009 Sep.
[Is] ISSN:1471-8405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To monitor the occurrence of cancer in a recently defined cohort of UK workers engaged in the manufacture of polyurethane elastomers using 4,4'-methylene-bis-ortho-chloroaniline. METHODS: A cohort of 308 male production workers from seven factories have been enumerated. All employees had a minimum of 12 months employment and were first employed at one of the participating factories in the period 1973-2000. Mortality and cancer incidence data for the period 1979-2007 were compared with expected values based on national rates. RESULTS: Mortality from all cancers combined was below the expected value [observed (Obs) 5, standardized mortality ratio (SMR) 68]. There was a single death from bladder cancer (SMR 560). The incidence of all cancers combined was also below expectation [Obs 9, standardized registration ratio (SRR) 77]. Site-specific incidence was unexceptional except there was a non-significant excess of bladder cancer based on two cases (SRR 328). CONCLUSIONS: The findings for bladder cancer should be treated with caution as they relate to a relatively early period of follow-up and are based on very small numbers.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/toxicidade
Indústria Química
Metilenobis (cloroanilina)/toxicidade
Neoplasias/epidemiologia
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/urina
Estudos de Coortes
Seres Humanos
Incidência
Masculino
Neoplasias/induzido quimicamente
Exposição Ocupacional/estatística & dados numéricos
Poliuretanos/síntese química
Fumar/epidemiologia
Neoplasias da Bexiga Urinária/induzido quimicamente
Neoplasias da Bexiga Urinária/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Polyurethanes); 3L2W5VTT2A (Methylenebis(chloroaniline))
[Em] Mês de entrada:1107
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090701
[St] Status:MEDLINE
[do] DOI:10.1093/occmed/kqp093



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