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[PMID]:28460440
[Au] Autor:Massari NA; Nicoud MB; Sambuco L; Cricco GP; Martinel Lamas DJ; Herrero Ducloux MV; Blanco H; Rivera ES; Medina VA
[Ad] Endereço:Laboratory of Radioisotopes, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
[Ti] Título:Histamine therapeutic efficacy in metastatic melanoma: Role of histamine H4 receptor agonists and opportunity for combination with radiation.
[So] Source:Oncotarget;8(16):26471-26491, 2017 Apr 18.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the combinatorial effect of histamine and gamma radiation on the radiobiological response of melanoma cells.Results indicate that 1205Lu metastatic melanoma cells express H4R and that histamine inhibits proliferation, in part through the stimulation of the H4R, and induces cell senescence and melanogenesis. Daily treatment with H4R agonists (1 mg/kg, sc) exhibited a significant in vivo antitumor effect and importantly, compounds reduced metastatic potential, particularly in the group treated with JNJ28610244, the H4R agonist with higher specificity. H4R is expressed in benign and malignant lesions of melanocytic lineage, highlighting the potential clinical use of histamine and H4R agonists. In addition, histamine increased radiosensitivity of melanoma cells in vitro and in vivo. We conclude that stimulation of H4R by specific ligands may represent a novel therapeutic strategy in those tumors that express this receptor. Furthermore, through increasing radiation-induced response, histamine could improve cancer radiotherapy for the treatment of melanoma.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Histamina/farmacologia
Melanoma/metabolismo
Melanoma/patologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/uso terapêutico
Biomarcadores
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Senescência Celular/efeitos dos fármacos
Terapia Combinada
Modelos Animais de Doenças
Histamina/uso terapêutico
Seres Humanos
Imuno-Histoquímica
Indóis/farmacologia
Melanoma/terapia
Camundongos
Camundongos Nus
Metástase Neoplásica
Estadiamento de Neoplasias
Oximas/farmacologia
Radiação Ionizante
Receptores Histamínicos H4/metabolismo
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers); 0 (Indoles); 0 (JNJ28610244); 0 (Oximes); 0 (Receptors, Histamine H4); 820484N8I3 (Histamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15594


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[PMID]:29239411
[Au] Autor:Ogasawara H; Grzybowski M; Hosokawa R; Sato Y; Taki M; Yamaguchi S
[Ad] Endereço:Department of Chemistry, Graduate School of Science and Integrated Research Consortium on Chemical Sciences (IRCCS), Nagoya University, Furo, Chikusa, Nagoya 464-8602, Japan.
[Ti] Título:A far-red fluorescent probe based on a phospha-fluorescein scaffold for cytosolic calcium imaging.
[So] Source:Chem Commun (Camb);54(3):299-302, 2018 Jan 02.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The far-red emissive fluorescent probe CaPF-1 based on a phospha-fluorescein scaffold enables the detection of cytosolic calcium ions in living cells. The probe can be excited in the red region (λ = 636 nm) and exhibits a sufficiently high fluorescence turn-on response in the far-red region (λ = 663 nm) upon complexation with calcium ions. The hydrophilic and anionic characteristics of this phospha-fluorescein fluorophore allowed the cytosolic localization of CaPF-1. Moreover, it was possible to visualize histamine-induced calcium oscillation in HeLa cells using CaPF-1.
[Mh] Termos MeSH primário: Cálcio/análise
Óxidos P-Cíclicos/farmacologia
Fluoresceínas/farmacologia
Corantes Fluorescentes/farmacologia
[Mh] Termos MeSH secundário: Cálcio/metabolismo
Óxidos P-Cíclicos/síntese química
Óxidos P-Cíclicos/química
Fluoresceínas/síntese química
Fluoresceínas/química
Fluorescência
Corantes Fluorescentes/síntese química
Corantes Fluorescentes/química
Células HeLa
Histamina/metabolismo
Seres Humanos
Concentração de Íons de Hidrogênio
Microscopia Confocal
Imagem Molecular
Imagem Óptica
Receptores Histamínicos H1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclic P-Oxides); 0 (Fluoresceins); 0 (Fluorescent Dyes); 0 (Receptors, Histamine H1); 820484N8I3 (Histamine); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1039/c7cc07344e


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[PMID]:28467354
[Au] Autor:Pal S; Meininger CJ; Gashev AA
[Ad] Endereço:Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center, Temple, TX 76504, USA. spal@medicine.tamhsc.edu.
[Ti] Título:Aged Lymphatic Vessels and Mast Cells in Perilymphatic Tissues.
[So] Source:Int J Mol Sci;18(5), 2017 May 03.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This review provides a comprehensive summary of research on aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues. Aging alters structure (by increasing the size of zones with low muscle cell investiture), ultrastructure (through loss of the glycocalyx), and proteome composition with a concomitant increase in permeability of aged lymphatic vessels. The contractile function of aged lymphatic vessels is depleted with the abolished role of nitric oxide and an increased role of lymphatic-born histamine in flow-dependent regulation of lymphatic phasic contractions and tone. In addition, aging induces oxidative stress in lymphatic vessels and facilitates the spread of pathogens from these vessels into perilymphatic tissues. Aging causes the basal activation of perilymphatic mast cells, which, in turn, restricts recruitment/activation of immune cells in perilymphatic tissues. This aging-associated basal activation of mast cells limits proper functioning of the mast cell/histamine/NF-κB axis that is essential for the regulation of lymphatic vessel transport and barrier functions as well as for both the interaction and trafficking of immune cells near and within lymphatic collecting vessels. Cumulatively, these changes play important roles in the pathogenesis of alterations in inflammation and immunity associated with aging.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Imunidade/imunologia
Inflamação/imunologia
Vasos Linfáticos/fisiologia
Tecido Linfoide/fisiologia
[Mh] Termos MeSH secundário: Animais
Histamina/metabolismo
Seres Humanos
Mastócitos/metabolismo
Camundongos
NF-kappa B/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (NF-kappa B); 820484N8I3 (Histamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:29338164
[Au] Autor:Novkovic D; Petrovic M; Zivkovic V; Baletic N
[Ti] Título:The relation between nonspecific hyperreactivity of the airways and atopic constitution in asthmatics.
[So] Source:Vojnosanit Pregl;73(11):1056-9, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Hyperreactivity of the airways caused by inflammation in asthmatics is the most important pathophysiological change. It represents a suitable ground that in the presence of risk factors and the drivers of asthma, asthmatic attack occurs. Atopic constitution is one of the most important risk factors for the development and expression of asthma. The aim of our study was to investigate the relationship between nonspecific airway hyperreactivity and atopic constituton in asthmatics. Methods: This retrospective analysis was conducted considering the results of nonspecific bronchoprovocative test with histamine, skin tests to inhalant allergens and total IgE levels in the serum of asthmatic patients with controlled bronchial asthma. The sample consisted of 162 asthmatics examined during one-year period. Results: The examinees were male asthmatic patients, aged between 18 and 30 years. We found that the examinees with a pronounced non-specific hyperreactivity had more significant skin reaction to inhaled allergens and higher levels of total IgE in serum. Conclusion: The results of our study show that the intensity of airway hyperresponsiveness to histamine in asthmatics is directly related to atopic constitution.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Hiper-Reatividade Brônquica/fisiopatologia
Broncoconstrição
Dermatite Atópica/imunologia
Pulmão/fisiopatologia
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Asma/diagnóstico
Asma/imunologia
Biomarcadores/sangue
Hiper-Reatividade Brônquica/diagnóstico
Hiper-Reatividade Brônquica/imunologia
Testes de Provocação Brônquica
Dermatite Atópica/sangue
Dermatite Atópica/diagnóstico
Histamina/administração & dosagem
Seres Humanos
Imunoglobulina E/sangue
Pulmão/imunologia
Masculino
Estudos Retrospectivos
Fatores de Risco
Testes Cutâneos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 37341-29-0 (Immunoglobulin E); 820484N8I3 (Histamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141029120N


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[PMID]:29269296
[Au] Autor:Hasegawa A; Watanabe M; Osada H; Ogawa M; Ohno H; Yanuma N; Sasaki K; Shimoda M; Shirai J; Ohmori K
[Ad] Endereço:Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
[Ti] Título:Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains.
[So] Source:Biochem Biophys Res Commun;495(3):2184-2188, 2018 01 15.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A time-of-day-dependent variation in IgE-mediated passive systemic anaphylaxis was previously reported in ICR mice. In the present study, we investigated time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor (PAF)-mediated systemic anaphylaxis in C57BL/6, BALB/c, and NC/Nga mice at 9:00 h and 21:00 h, and evaluated the potential influence of glucocorticoids (GCs) on these variations. We found significant time-of-day-dependent variations in IgE-mediated systemic anaphylaxis in C57BL/6 mice, and in histamine- and PAF-mediated systemic anaphylaxis in BALB/c mice. Significant daily variations in IgE-, histamine-, and PAF-mediated systemic anaphylaxis were not observed in NC/Nga mice. Pretreatment with dexamethasone and adrenalectomy abolished the daily variations in IgE-mediated systemic anaphylaxis in C57BL/6 mice and in PAF-mediated systemic anaphylaxis in BALB/c mice, suggesting that GCs from adrenal glands are pivotal in regulating these variations. In contrast, pretreatment with dexamethasone and adrenalectomy did not abolish the daily variation in histamine-mediated systemic anaphylaxis in BALB/c mice, suggesting that GC-independent and adrenal gland-independent mechanisms are important for the variation. The present study demonstrated that time-of-day-dependent variations in systemic anaphylaxis differed among inbred mouse strains and with anaphylaxis-inducing substances. Thus, mouse strains, time of experiment, and anaphylaxis-inducing substances used must be considered to obtain appropriate experimental results.
[Mh] Termos MeSH primário: Anafilaxia/metabolismo
Ritmo Circadiano
Modelos Animais de Doenças
Glucocorticoides/metabolismo
Histamina/metabolismo
Imunoglobulina E/metabolismo
Fator de Ativação de Plaquetas/metabolismo
[Mh] Termos MeSH secundário: Animais
Masculino
Camundongos/classificação
Camundongos/metabolismo
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos ICR
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Platelet Activating Factor); 37341-29-0 (Immunoglobulin E); 820484N8I3 (Histamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE


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[PMID]:28747471
[Au] Autor:Chapman PD; Bradley SP; Haught EJ; Riggs KE; Haffar MM; Daly KC; Dacks AM
[Ad] Endereço:Department of Biology, West Virginia University, Morgantown, WV 26506, USA.
[Ti] Título:Co-option of a motor-to-sensory histaminergic circuit correlates with insect flight biomechanics.
[So] Source:Proc Biol Sci;284(1859), 2017 Jul 26.
[Is] ISSN:1471-2954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nervous systems must adapt to shifts in behavioural ecology. One form of adaptation is neural exaptation, in which neural circuits are co-opted to perform additional novel functions. Here, we describe the co-option of a motor-to-somatosensory circuit into an olfactory network. Many moths beat their wings during odour-tracking, whether walking or flying, causing strong oscillations of airflow around the antennae, altering odour plume structure. This self-induced sensory stimulation could impose selective pressures that influence neural circuit evolution, specifically fostering the emergence of corollary discharge circuits. In , a pair of mesothoracic to deutocerebral histaminergic neurons (MDHns), project from the mesothoracic neuromere to both antennal lobes (ALs), the first olfactory neuropil. Consistent with a hypothetical role in providing the olfactory system with a corollary discharge, we demonstrate that the MDHns innervate the ALs of advanced and basal moths, but not butterflies, which differ in wing beat and flight pattern. The MDHns probably arose in crustaceans and in many arthropods innervate mechanosensory areas, but not the olfactory system. The MDHns, therefore, represent an example of architectural exaptation, in which neurons that provide motor output information to mechanosensory regions have been co-opted to provide information to the olfactory system in moths.
[Mh] Termos MeSH primário: Voo Animal
Manduca/fisiologia
Neurônios/fisiologia
Bulbo Olfatório/fisiologia
[Mh] Termos MeSH secundário: Animais
Histamina
Olfato/fisiologia
Asas de Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
820484N8I3 (Histamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


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[PMID]:28458423
[Au] Autor:Sharma S; Rasal VP; Patil PA; Joshi RK
[Ad] Endereço:Department of Pharmacology, KLE University, College of Pharmacy, Belgaum, Karnataka, India.
[Ti] Título:Effect of essential oil on allergic airway changes induced by histamine and ovalbumin in experimental animals.
[So] Source:Indian J Pharmacol;49(1):55-59, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Edgew (Apiaceae) is used in traditional medicine for treatment of several diseases including bronchial asthma. The present investigation was aimed to evaluate broncho-relaxant activity of essential oil in histamine and ovalbumin (OVA)-induced broncho constriction in experimental animals. MATERIALS AND METHODS: Airway was induced using histamine aerosol in guinea pigs ( = 24) and OVA aerosol in albino mice ( = 24). The number of inflammatory cells, namely, absolute eosinophils count in blood, total immunoglobulin E (IgE) in serum, eosinophils, and neutrophils in bronchoalveolar lavage fluid (BALF) and histopathological examination of lung tissues were investigated in oil and dexamethasone-treated groups. oil 200 µL/kg was given orally, and dexamethasone 2 mg/kg was given intraperitoneal. Both the treatments were repeated daily for 7 days. Results were analyzed by one-way ANOVA, and ≤ 0.05 was considered statistically significant. RESULTS: Treatment with essential oil significantly ( < 0.001) increased the time of preconvulsive dyspnea in histamine-induced guinea pigs. Oral treatment of oil significantly ( < 0.001) decreased absolute blood eosinophil count (from 325 ± 3.69 to 200 ± 3.05 cells/mm ), serum level of IgE (from 6.10 ± 0.05 to 0.70 ± 0.08 IU/L), and the number of eosinophils (from 11.0% ±1.41% to 3.0% ±0.51%), neutrophils (from 13.0% ±1.12% to 5.0% ±1.39%) in BALF. Histopathological changes observed in lungs of untreated group were marked suppressed by treatment with oil. CONCLUSION: The essential oil of has bronchorelaxation in both histamine and OVA-induced bronchoconstriction in animals. The traditional use of against asthma could be attributed to its bronchodilator property as observed in the present study.
[Mh] Termos MeSH primário: Angelica/química
Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Asma/tratamento farmacológico
Asma/imunologia
Líquido da Lavagem Broncoalveolar
Broncoconstrição/imunologia
Broncodilatadores/administração & dosagem
Broncodilatadores/isolamento & purificação
Dexametasona/farmacologia
Modelos Animais de Doenças
Eosinófilos/efeitos dos fármacos
Eosinófilos/metabolismo
Feminino
Cobaias
Histamina/imunologia
Imunoglobulina E/sangue
Camundongos
Neutrófilos/efeitos dos fármacos
Neutrófilos/metabolismo
Óleos Voláteis/administração & dosagem
Óleos Voláteis/isolamento & purificação
Ovalbumina/imunologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Oils, Volatile); 37341-29-0 (Immunoglobulin E); 7S5I7G3JQL (Dexamethasone); 820484N8I3 (Histamine); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201019


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[PMID]:28458421
[Au] Autor:Saikia B; Barua CC; Haloi P; Patowary P
[Ad] Endereço:Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Guwahati, Assam, India.
[Ti] Título:Anticholinergic, antihistaminic, and antiserotonergic activity of n-hexane extract of seeds on isolated tissue preparations: An study.
[So] Source:Indian J Pharmacol;49(1):42-48, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to evaluate anticholinergic, antihistaminic, and antiserotonergic activity of the n-hexane extract of the seeds of (ZAHE) on isolated ileum of rat and guinea pig and fundus of rat. MATERIALS AND METHODS: ZAHE was prepared using soxhlet extraction and cumulative concentration response curves were constructed using various doses on the tissues for acetylcholine (ACh), 5-hydroxytryptamine (5-HT), and histamine with or without n-hexane extract. Atropine, ketanserin, and pheniramine maleate were used as antagonists for ACh, serotonin, and histamine, respectively. RESULTS: ZAHE-induced concentration-dependent inhibition of isolated ileum and fundus in rat and ileum of guinea pig. The half maximal effective concentration (EC ) of ACh in the presence of atropine (10 M; < 0.05) and ZAHE (1000 µg/ml; < 0.01) was significantly higher than EC of ACh alone. The EC of 5-HT in the presence of ketanserin (10 M; < 0.01) and ZAHE (1000 µg/ml; < 0.05) was higher than EC of 5-HT alone. Similarly, the EC of histamine in the presence of pheniramine maleate (10 M; < 0.01) and ZAHE (300 µg/ml; < 0.01 and 1000 µg/ml; < 0.05) was also significantly higher than EC of histamine alone. CONCLUSION: From the study, it was observed that ZAHE shows significant anticholinergic, antiserotonergic, and antihistaminic activity. The study provides sufficient evidence that the seeds can be used in gastric disorders, cough, chest infection, etc., as per folklore claims.
[Mh] Termos MeSH primário: Antagonistas Colinérgicos/farmacologia
Antagonistas dos Receptores Histamínicos/farmacologia
Extratos Vegetais/farmacologia
Antagonistas da Serotonina/farmacologia
Zanthoxylum/química
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Animais
Antagonistas Colinérgicos/administração & dosagem
Antagonistas Colinérgicos/isolamento & purificação
Relação Dose-Resposta a Droga
Fundo Gástrico/efeitos dos fármacos
Fundo Gástrico/metabolismo
Cobaias
Hexanos/química
Histamina/metabolismo
Antagonistas dos Receptores Histamínicos/administração & dosagem
Antagonistas dos Receptores Histamínicos/isolamento & purificação
Íleo/efeitos dos fármacos
Íleo/metabolismo
Masculino
Extratos Vegetais/administração & dosagem
Ratos
Ratos Wistar
Sementes
Serotonina/metabolismo
Antagonistas da Serotonina/administração & dosagem
Antagonistas da Serotonina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinergic Antagonists); 0 (Hexanes); 0 (Histamine Antagonists); 0 (Plant Extracts); 0 (Serotonin Antagonists); 2DDG612ED8 (n-hexane); 333DO1RDJY (Serotonin); 820484N8I3 (Histamine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201025


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[PMID]:29215841
[Au] Autor:Orazov MR; Radzinskiy VY; Khamoshina MB; Nosenko EN; Tokaeva ES; Barsegyan LK; Zakirova YR
[Ti] Título:[Histamine metabolism disorder in pathogenesis of chronic pelvic pain in patients with external genital endometriosis].
[So] Source:Patol Fiziol Eksp Ter;61(2):56-60, 2017 Apr-Jun.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Objective. To study features of histamine metabolism in patients with chronic pelvic pain associated with external genital endometriosis. Methods. For quantitative assessment of histamine level in peripheral blood was taken from 100 patients which than was centrifuged. In blood serum histamine concentration was determined by enzyme-linked immunosorbent assay method with reagents «Histamine ЕLISA¼ on the machine BAE-1000 Histamine (Labor Diagnostika Nord - LDN, Hermany). A pain syndrome was assessed by Visual Analog Scale (VAS), quality of life assessment - by Endometriosis Health Profile Questionnaire (EHR-30), level of anxiety was determined by Spielberger-Khanin questionnaire. The results. Showed statistically higher histamine level in patients with severe pain according to VAS. After assessment of results obtained from Spielberger-Khanin questionnaire 100% experimental group's women with external genital endometriosis (n = 60) were noted to be have high level of state and trait anxiety, then 40% women of control group (n = 16) have moderate level of anxiety. The incidence of depression in women with chronic pelvic pain was 58.3% (n = 35) and the main part (n = 20) were women with severe stage of pelvic pain according to VAS. Conclusions. Psycho emotional condition of women with external genital endometriosis associated pelvic pain characterized by higher depression and anxiety levels, with significant decrease quality of life. Direct relationship also was found between pain syndrome intensity and histamine level in peripheral blood in patients with external genital endometriosis.
[Mh] Termos MeSH primário: Ansiedade/sangue
Dor Crônica/sangue
Endometriose/sangue
Histamina/sangue
Dor Pélvica/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ansiedade/psicologia
Dor Crônica/psicologia
Endometriose/psicologia
Feminino
Seres Humanos
Dor Pélvica/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
820484N8I3 (Histamine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


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[PMID]:28964277
[Au] Autor:Yu C; Li L; Xia Q; Tang Y
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
[Ti] Título:Expression and localization of histamine H , H , and H receptors in rat olfactory epithelium.
[So] Source:Int J Pediatr Otorhinolaryngol;101:102-106, 2017 Oct.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Histamine is an important chemical mediator in the development of allergic rhinitis and plays a key role in eliciting the nasal symptoms of the disorder. Histamine may also affect smell as a neurotransmitter. However, whether histamine receptors are present in the mammalian olfactory epithelium has not yet been examined. The aim of this study was to investigate the expression and distribution of histamine H , H , and H receptors in rat olfactory epithelium. METHODS: Real-time quantitative PCR and immunohistochemical staining were performed to examine the mRNA level and protein expression and localization of histamine receptors (H , H , and H ) in rat olfactory epithelium. RESULTS: We demonstrated that mRNAs encoding histamine H , H , and H receptors were detected in rat olfactory epithelium. Immunohistochemistry also showed strong positive staining for these receptors. Co-localization of histamine H , H , and H receptors with olfactory mature protein revealed that these three histamine receptors were mainly localized in olfactory receptor neurons. CONCLUSIONS: These findings indicate that histamine H , H , and H receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission.
[Mh] Termos MeSH primário: Mucosa Olfatória/metabolismo
Receptores Histamínicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Histamina
Imuno-Histoquímica
Masculino
Ratos
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Histamine); 820484N8I3 (Histamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE



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