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Referências encontradas : 303 [refinar]
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[PMID]:26726052
[Au] Autor:Sawicka KM; Goez H; Huntsman RJ
[Ad] Endereço:Undergraduate Medical Education Program, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
[Ti] Título:Successful Treatment of Paroxysmal Movement Disorders of Infancy With Dimenhydrinate and Diphenhydramine.
[So] Source:Pediatr Neurol;56:72-75, 2016 Mar.
[Is] ISSN:1873-5150
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Paroxysmal movement disorders including paroxysmal tonic upward gaze of infancy and paroxysmal dystonia of infancy are benign but uncommon movement disorders seen in young children. Although symptoms are intermittent and resolve spontaneously, they can cause discomfort and distress for the child. Current treatment options are limited to dopaminergic agents or anticonvulsants with limited efficacy. PATIENT DESCRIPTION: The authors present a child with paroxysmal tonic upward gaze of infancy and another with paroxysmal dystonia of infancy, both of whom responded successfully to treatment with low-dose dimenhydrinate or diphenhydramine, respectively. DISCUSSION: Dimenhydrinate and diphenhydramine both exert anticholinergic activity and have limited toxicity at low doses. This property makes either compound an attractive therapeutic option for paroxysmal movement disorders in infancy. These agents are generally well tolerated.
[Mh] Termos MeSH primário: Dimenidrinato/uso terapêutico
Difenidramina/uso terapêutico
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Transtornos dos Movimentos/tratamento farmacológico
[Mh] Termos MeSH secundário: Eletroencefalografia
Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine H1 Antagonists); 8GTS82S83M (Diphenhydramine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160105
[St] Status:MEDLINE


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[PMID]:26659910
[Au] Autor:Scholtz AW; Ilgner J; Loader B; Pritschow BW; Weisshaar G
[Ad] Endereço:Department of Otorhinolaryngology, Division of Neurotology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. arne.scholtz@i-med.ac.at.
[Ti] Título:Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice.
[So] Source:Wien Klin Wochenschr;128(9-10):341-7, 2016 May.
[Is] ISSN:1613-7671
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:The efficacy and safety of the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg in the treatment of vertigo of various origins have been investigated in a prospective, noninterventional study involving private practices throughout Germany. A total of 1275 patients with an average age of 61.2 years participated in the study. The vertigo symptoms, measured by a validated mean vertigo score (primary efficacy endpoint) improved by 61 % in the course of the observational period (median: 6 weeks). Concomitant symptoms frequently associated with vertigo such as nausea, vomiting and tinnitus were also markedly reduced by 84, 85 and 51 %, respectively. Overall efficacy has been rated by the physicians as 'very much improved' or 'much improved' in 95 % of the patients. A total of 47 patients (3.7 %) reported 51 adverse drug reactions (all nonserious). The results indicate a good tolerability and efficacy of the fixed combination of cinnarizine and dimenhydrinate in the treatment of vertigo in daily medical practice, which is in line with previous findings of numerous interventional, randomised, double-blind, controlled clinical trials.
[Mh] Termos MeSH primário: Cinarizina/uso terapêutico
Dimenidrinato/uso terapêutico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle
Vertigem/tratamento farmacológico
Vertigem/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Antieméticos/uso terapêutico
Feminino
Alemanha/epidemiologia
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Seres Humanos
Masculino
Meia-Idade
Prevalência
Fatores de Risco
Distribuição por Sexo
Resultado do Tratamento
Vertigem/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antiemetics); 0 (Histamine H1 Antagonists); 3DI2E1X18L (Cinnarizine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1007/s00508-015-0905-5


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[PMID]:26460061
[Au] Autor:Yildiz Pekoz A; Sedef Erdal M; Okyar A; Ocak M; Tekeli F; Kaptan E; Sagirli O; Araman A
[Ad] Endereço:a Department of Pharmaceutical Technology , Faculty of Pharmacy, Istanbul University , Beyazit-Istanbul , Turkey .
[Ti] Título:Preparation and in-vivo evaluation of dimenhydrinate buccal mucoadhesive films with enhanced bioavailability.
[So] Source:Drug Dev Ind Pharm;42(6):916-25, 2016.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dimenhydrinate (DMH)-loaded buccal bioadhesive films for the prevention and treatment of motion sickness were prepared and optimized. This study examines the rate of drug release from the films for prolonged periods of time to reduce or limit the frequency of DMH administration. Based on preliminary studies using various polymers and concentrations, hydroxyethylcellulose (2.5, 3.0, and 3.2%), and xanthan gum (2.8%) were chosen as matrix polymers. The films were analyzed with respect to their mechanical, physicochemical, bioadhesive, swelling, and in-vitro release properties. In in-vivo pharmacokinetic studies, xanthan gum-based DMH buccal film was associated with significantly increased DMH plasma levels between 1 h and 5 h after DMH dosing when compared with an oral drug solution. The area under the curve AUC0-7 h value of the mucoadhesive buccal film was two-fold higher than the oral DMH solution. Histological analysis revealed that DMH films cause mild morphological and inflammatory changes in rabbit buccal mucosa. The DMH buccal film is effective for approximately 7 h, thus representing an option for single-dose antiemetic therapy. This dosage regimen could be particularly beneficial for chain travelers who travel for long periods of time.
[Mh] Termos MeSH primário: Adesivos/administração & dosagem
Adesivos/química
Dimenidrinato/administração & dosagem
Dimenidrinato/química
Mucosa Bucal/metabolismo
[Mh] Termos MeSH secundário: Administração Bucal
Animais
Área Sob a Curva
Disponibilidade Biológica
Celulose/análogos & derivados
Celulose/química
Química Farmacêutica/métodos
Dimenidrinato/farmacocinética
Masculino
Polissacarídeos Bacterianos/química
Coelhos
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adhesives); 0 (Polysaccharides, Bacterial); 9004-34-6 (Cellulose); 9004-62-0 (hydroxyethylcellulose); JB937PER5C (Dimenhydrinate); TTV12P4NEE (xanthan gum)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151014
[St] Status:MEDLINE
[do] DOI:10.3109/03639045.2015.1091470


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[PMID]:26354946
[Au] Autor:Lamie NT; Monir HH
[Ad] Endereço:Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.
[Ti] Título:Simultaneous Determination of Cinnarizine and Dimenhydrinate in Binary Mixture Using Chromatographic Methods.
[So] Source:J Chromatogr Sci;54(1):36-42, 2016 Jan.
[Is] ISSN:1945-239X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two accurate and sensitive chromatographic methods have been developed and validated for simultaneous determination of cinnarizine (CIN) and dimenhydrinate (DIM). The first method uses simultaneous quantitative thin layer chromatography (TLC) spectrodensitometric evaluation of them, using ethyl acetate:methylene chloride (8 : 2 by volume) as a mobile phase. Chromatograms are scanned at 254 nm. This method analyzes CIN in a concentration range of 0.5-6 µg per band with mean percentage recovery of 99.78 ± 1.001 and DIM in a concentration range of 1-6 µg per band with mean percentage recovery of 99.87 ± 1.319. The second method is high-performance liquid chromatography using methanol:acetonitrile:water [85 : 10 : 5, by volume +0.5% tri ethyl amine (TEA)] as a mobile phase. The linearity was found to be in the range of 10-60 and 5-60 µg mL(-1) for CIN and DIM, respectively. The methods were successfully applied to the simultaneous determination of CIN and DIM in bulk powder, laboratory-prepared mixtures and pharmaceutical dosage forms. The validity of results was assessed by applying standard addition techniques. The results obtained are found to agree statistically with those obtained by a reported method, showing no significant difference with respect to accuracy and precision.
[Mh] Termos MeSH primário: Cromatografia em Camada Delgada/métodos
Cinarizina/análise
Misturas Complexas
Dimenidrinato/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Complex Mixtures); 3DI2E1X18L (Cinnarizine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151217
[Lr] Data última revisão:
151217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150911
[St] Status:MEDLINE
[do] DOI:10.1093/chromsci/bmv103


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[PMID]:26688907
[Ti] Título:Diphenhydramine, dimenhydrinate: misuse.
[So] Source:Prescrire Int;24(165):270, 2015 Nov.
[Is] ISSN:1167-7422
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Dimenidrinato/efeitos adversos
Difenidramina/efeitos adversos
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
[Mh] Termos MeSH secundário: Dimenidrinato/administração & dosagem
Difenidramina/administração & dosagem
França/epidemiologia
Antagonistas dos Receptores Histamínicos H1/administração & dosagem
Antagonistas dos Receptores Histamínicos H1/efeitos adversos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine H1 Antagonists); 8GTS82S83M (Diphenhydramine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151221
[Lr] Data última revisão:
151221
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE


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[PMID]:26037548
[Au] Autor:Teggi R; Colombo B; Gatti O; Comi G; Bussi M
[Ad] Endereço:ENT Division, San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy. teggi.roberto@hsr.it.
[Ti] Título:Fixed combination of cinnarizine and dimenhydrinate in the prophylactic therapy of vestibular migraine: an observational study.
[So] Source:Neurol Sci;36(10):1869-73, 2015 Oct.
[Is] ISSN:1590-3478
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Vestibular migraine (VM) is one of the most frequent causes of episodic vertigo, with a lifetime prevalence of 0.98%. Prophylactic therapy includes calcium channel blockers, beta-blockers, antiepileptic drugs and antidepressants. We studied the association of cinnarizine 20 mg and dimenhydrinate 40 mg (Arlevertan) in a group of 22 patients affected by definite VM. Proposed therapy included one tablet twice a day for 1 month, which was repeated three times with 1 month of interval between drug intake; results were compared with those of a control group of 11 VM patients who asked to observe only lifestyle measures for migraine. The main outcome was the number of vertigo and headache crises in the 6 months before therapy and in the 6 months of follow-up. Subjects performing Arlevertan presented during the 6 months of therapy a decrease of vertigo attacks from 5.3 to 2.1 and of headaches from 4.3 to 1.7 (p < 0.0001); 68% of these subjects reported a decrease of at least 50% of vertigo attacks, while 63% of headaches. Conversely, vertigo attacks decreased from 3.5 to 2.2 and headaches from 2.6 to 2 in patients observing only lifestyle; 18% of these subjects reported a decrease of at least 50% of vertigo crises and 27% of headaches. Our data do not differ from those of previous works assessing efficacy of different prophylactic therapies for VM and reporting consistent reduction of vertigo spells in a rate of patients ranging from 60 and 80%.
[Mh] Termos MeSH primário: Bloqueadores dos Canais de Cálcio/uso terapêutico
Cinarizina/uso terapêutico
Dimenidrinato/uso terapêutico
Transtornos de Enxaqueca/tratamento farmacológico
Doenças Vestibulares/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Combinação de Medicamentos
Feminino
Seguimentos
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Seres Humanos
Masculino
Transtornos de Enxaqueca/fisiopatologia
Fatores de Tempo
Resultado do Tratamento
Vertigem/tratamento farmacológico
Vertigem/fisiopatologia
Doenças Vestibulares/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Calcium Channel Blockers); 0 (Drug Combinations); 0 (Histamine H1 Antagonists); 0 (cinnarizine, dimenhydrinate drug combination); 3DI2E1X18L (Cinnarizine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150604
[St] Status:MEDLINE
[do] DOI:10.1007/s10072-015-2270-6


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[PMID]:26037499
[Au] Autor:Lamie NT; Yehia AM
[Ad] Endereço:Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, 11562 Cairo, Egypt.
[Ti] Título:Development of normalized spectra manipulating spectrophotometric methods for simultaneous determination of Dimenhydrinate and Cinnarizine binary mixture.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;150:142-50, 2015.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Simultaneous determination of Dimenhydrinate (DIM) and Cinnarizine (CIN) binary mixture with simple procedures were applied. Three ratio manipulating spectrophotometric methods were proposed. Normalized spectrum was utilized as a divisor for simultaneous determination of both drugs with minimum manipulation steps. The proposed methods were simultaneous constant center (SCC), simultaneous derivative ratio spectrophotometry (S(1)DD) and ratio H-point standard addition method (RHPSAM). Peak amplitudes at isoabsorptive point in ratio spectra were measured for determination of total concentrations of DIM and CIN. For subsequent determination of DIM concentration, difference between peak amplitudes at 250 nm and 267 nm were used in SCC. While the peak amplitude at 275 nm of the first derivative ratio spectra were used in S(1)DD; then subtraction of DIM concentration from the total one provided the CIN concentration. The last RHPSAM was a dual wavelength method in which two calibrations were plotted at 220 nm and 230 nm. The coordinates of intersection point between the two calibration lines were corresponding to DIM and CIN concentrations. The proposed methods were successfully applied for combined dosage form analysis, Moreover statistical comparison between the proposed and reported spectrophotometric methods was applied.
[Mh] Termos MeSH primário: Antieméticos/análise
Cinarizina/análise
Dimenidrinato/análise
Antagonistas dos Receptores Histamínicos H1/análise
Espectrofotometria/métodos
[Mh] Termos MeSH secundário: Formas de Dosagem
Combinação de Medicamentos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiemetics); 0 (Dosage Forms); 0 (Drug Combinations); 0 (Histamine H1 Antagonists); 3DI2E1X18L (Cinnarizine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:150825
[Lr] Data última revisão:
150825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150604
[St] Status:MEDLINE


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[PMID]:25919820
[Au] Autor:Luxen J; Trentzsch H; Urban B; Prückner S
[Ti] Título:[Antiemetic therapy in preclinical emergency medicine - a literature review].
[Ti] Título:Antiemetische Therapie in der präklinischen Notfallmedizin - Aktuelle Studienlage..
[So] Source:Anasthesiol Intensivmed Notfallmed Schmerzther;50(4):238-43, 2015 Apr.
[Is] ISSN:1439-1074
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Nausea and vomiting are frequent symptoms in emergency medicine and require a targeted drug intervention. Despite known disadvantages in terms of efficacy and side effects, metoclopramide is still often used in the emergency medical service to treat nausea and vomiting. Recent studies show that, especially in the therapy of opioid-triggered vomiting, metoclopramide is not significantly effective when compared to placebo. Dimenhydrinate seems to be an effective drug for various forms of nausea, but can often be relatively or absolutely contraindicated in emergency medicine due to its sedative effect. Based on a literature review, 5-HT3-antagonists appear to be a good alternative for the treatment of emesis in the emergency service. However, as for all antiemetics, the maximum dosage and potential side effects need to be paid attention to. In addition, neither of the 5-HT3-antagonists are approved for therapy of non-chemotherapy-induced vomiting or PONV. In conclusion, it may be considered to include 5-HT3-antagonists in addition to dimenhydrinate in the ambulance medical equipment. The routine use of a specific antiemetic is not recommended.
[Mh] Termos MeSH primário: Antieméticos/uso terapêutico
Serviços Médicos de Emergência/métodos
[Mh] Termos MeSH secundário: Dimenidrinato/uso terapêutico
Medicina de Emergência
Seres Humanos
Metoclopramida/uso terapêutico
Náusea e Vômito Pós-Operatório/prevenção & controle
Antagonistas do Receptor 5-HT3 de Serotonina/uso terapêutico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiemetics); 0 (Serotonin 5-HT3 Receptor Antagonists); JB937PER5C (Dimenhydrinate); L4YEB44I46 (Metoclopramide)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150429
[Lr] Data última revisão:
150429
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150429
[St] Status:MEDLINE
[do] DOI:10.1055/s-0041-100894


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[PMID]:25767869
[Ti] Título:[Vertigo in the elderly. Effective therapy options].
[Ti] Título:Schwindel im Alter. Wirksame Therapieoptionen..
[So] Source:MMW Fortschr Med;157(1):71, 2015 Jan 19.
[Is] ISSN:1438-3276
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Cinarizina/uso terapêutico
Dimenidrinato/uso terapêutico
Doença de Meniere/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Relação Dose-Resposta a Droga
Esquema de Medicação
Combinação de Medicamentos
Seres Humanos
Doença de Meniere/etiologia
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Drug Combinations); 0 (cinnarizine, dimenhydrinate drug combination); 3DI2E1X18L (Cinnarizine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150313
[Lr] Data última revisão:
150313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150314
[St] Status:MEDLINE


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[PMID]:25677532
[Au] Autor:Lamie NT
[Ad] Endereço:Cairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Kasr El-Aini Street, ET 11562 Cairo, Egypt. Electronic address: nesrinelamie@hotmail.com.
[Ti] Título:Comparative study of spectrophotometric methods manipulating ratio spectra: an application on pharmaceutical binary mixture of cinnarizine and dimenhydrinate.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;141:193-201, 2015 Apr 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four simple, specific, accurate and precise spectrophotometric methods are developed and validated for simultaneous determination of cinnarizine (CIN) and dimenhydrinate (DIM) in a binary mixture with overlapping spectra, without preliminary separation. The first method is dual wavelength spectrophotometry (DW), the second is a ratio difference spectrophotometric one (RD) which measures the difference in amplitudes between 250 and 270 nm of ratio spectrum, the third one is novel constant center spectrophotometric method (CC) and the fourth method is mean centering of ratio spectra (MCR). The calibration curve is linear over the concentration range of 4-20 and 10-45 µg/ml for CIN and DIM, respectively. These methods are tested by analyzing synthetic mixtures of the above drugs and they are applied to commercial pharmaceutical preparation of the subjected drugs. The validity of results was assessed by applying standard addition technique. The results obtained were found to agree statistically with those obtained by a reported method, showing no significant difference with respect to accuracy and precision.
[Mh] Termos MeSH primário: Cinarizina/análise
Dimenidrinato/análise
Preparações Farmacêuticas/análise
Espectrofotometria/métodos
[Mh] Termos MeSH secundário: Cinarizina/química
Dimenidrinato/química
Preparações Farmacêuticas/química
Padrões de Referência
Reprodutibilidade dos Testes
Estatística como Assunto
Comprimidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Tablets); 3DI2E1X18L (Cinnarizine); JB937PER5C (Dimenhydrinate)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150227
[Lr] Data última revisão:
150227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150214
[St] Status:MEDLINE



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