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[PMID]:29406033
[Au] Autor:Alsenedi KA; Morrison C
[Ad] Endereço:Forensic Medicine and Science, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom. Electronic address: khalid.alsenedi@formed.gla.ac.uk.
[Ti] Título:Determination and long-term stability of twenty-nine cathinones and amphetamine-type stimulants (ATS) in urine using gas chromatography-mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1076:91-102, 2018 Feb 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A method was developed for the screening and quantification of seven amphetamine-type stimulants (ATS) and 22 cathinones, including three metabolites, in urine with Gas Chromatography-Mass Spectrometry. This method allowed the detection and quantification of ATS and cathinones group molecules using one procedure. A study of the stability of the drug mixtures for a period of 201 days in human urine samples under three different conditions has been carried. The ATS and cathinones include amphetamine, methamphetamine, MDA, MDEA, MDMA, PMA, PMMA, cathinone, methcathinone, 3'-position-substituted, ring-substituted, methylenedioxy-substituted, N-alkyl-substituted and pyrrolidinyl-substituted. Twenty drugs out of twenty-nine were validated with a quantitative method. This method can be applied to the nine remaining drugs as a screening method. The linearity of the assay was from 50 to 2000 ng/ml, with limits of detection of 0.5 to 10 ng/ml. In terms of accuracy, between-run and within-run precision were ≤20% for 20 compounds with good selectivity. No carryover was seen, and the recovery was between 80 and 120% for most drugs tested. ATS and pyrrolidinyl-substituted groups were conducted to be stable compounds under all conditions. All compounds tested were stable at -20 °C. Some cathinones were primarily degraded after 21 days at 4 °C. They were detectable but unstable after 201 days at 4 °C. Most cathinones were unstable after a day and completely lost after 28 days at RT.
[Mh] Termos MeSH primário: Alcaloides/urina
Anfetamina/urina
Cromatografia Gasosa-Espectrometria de Massas/métodos
[Mh] Termos MeSH secundário: Alcaloides/química
Anfetamina/química
Estabilidade de Medicamentos
Seres Humanos
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 540EI4406J (cathinone); CK833KGX7E (Amphetamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29413579
[Au] Autor:Hegstad S; Havnen H; Helland A; Spigset O; Frost J
[Ad] Endereço:Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway. Electronic address: solfrid.hegstad@stolav.no.
[Ti] Título:Enantiomeric separation and quantification of R/S-amphetamine in urine by ultra-high performance supercritical fluid chromatography tandem mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:7-12, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To distinguish between legal and illegal consumption of amphetamine reliable analytical methods for chiral separation of the R- and S-enantiomers of amphetamine in biological specimens are required. In this regard, supercritical fluid chromatography (SFC) has several potential advantages over liquid chromatography, including rapid separation of enantiomers due to low viscosity and high diffusivity of supercritical carbon dioxide, the main component in the SFC mobile phase. A method for enantiomeric separation and quantification of R- and S-amphetamine in urine was developed and validated using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS). Sample preparation prior to UHPSFC-MS/MS analysis was a semi-automatic solid phase extraction method. The UHPSFC-MS/MS method used a Chiralpak AD-3 column with a mobile phase consisting of CO and 0.2% cyclohexylamine in 2-propanol. The injection volume was 2 µL and run-time was 6 min. MS/MS detection was performed with positive electrospray ionization and two multiple reaction monitoring transitions (m/z 136.1 > 119.0 and m/z 136.1 > 91.0). The calibration range was 50-10,000 ng/mL for each enantiomer. The between-assay relative standard deviations were in the range of 3.7-7.6%. Recovery was 92-93% and matrix effects ranged from 100 to 104% corrected with internal standard. After development and validation, the method has been successfully implemented in routine use at our laboratory for both separation and quantification of R/S-amphetamine, and has proved to be a reliable and useful tool for distinguishing intake of R- and S-amphetamine in authentic patient samples.
[Mh] Termos MeSH primário: Anfetamina/química
Anfetamina/urina
Cromatografia Líquida de Alta Pressão/métodos
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estabilidade de Medicamentos
Feminino
Seres Humanos
Limite de Detecção
Modelos Lineares
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Estereoisomerismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
CK833KGX7E (Amphetamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29465560
[Au] Autor:Xue X; Song Y; Yu X; Fan Q; Tang J; Chen X
[Ad] Endereço:Department of Substance Abuse, Qingdao Mental Health Center, Qingdao.
[Ti] Título:Olanzapine and haloperidol for the treatment of acute symptoms of mental disorders induced by amphetamine-type stimulants: A randomized controlled trial.
[So] Source:Medicine (Baltimore);97(8):e9786, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants (ATSs). METHODS: The Zelen II design method was used; 124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group (n = 63) and haloperidol group (n = 61). Then, a 4-week open-label medical therapy was performed. Clinical Global Impression Scale Item 2 was employed to evaluate the onset time; meanwhile, Brief Psychiatric Rating Scale (BPRS) was used at baseline and at posttreatment weeks 1, 2, and 4. Moreover, adverse reactions during the treatment were recorded. RESULTS: Onset time in the olanzapine group was significantly earlier than in the haloperidol group; BPRS scores in the olanzapine group were significantly lower than haloperidol group values at 1 and 2 weeks of treatment. The overall effective rates had no statistically significant difference. CONCLUSION: Short-term olanzapine and haloperidol treatments had equivalent efficacies in the treatment of acute symptoms of mental disorders due to ATSs; however, olanzapine administration resulted in relatively earlier disease onset, with less adverse reactions.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/tratamento farmacológico
Antipsicóticos/administração & dosagem
Benzodiazepinas/administração & dosagem
Haloperidol/administração & dosagem
Transtornos Mentais/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Anfetamina/efeitos adversos
Transtornos Relacionados ao Uso de Anfetaminas/psicologia
Escalas de Graduação Psiquiátrica Breve
Estimulantes do Sistema Nervoso Central/efeitos adversos
Feminino
Seres Humanos
Masculino
Transtornos Mentais/induzido quimicamente
Projetos de Pesquisa
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Central Nervous System Stimulants); 12794-10-4 (Benzodiazepines); CK833KGX7E (Amphetamine); J6292F8L3D (Haloperidol); N7U69T4SZR (olanzapine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009786


  4 / 10765 MEDLINE  
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[PMID]:29360121
[Au] Autor:Pregeljc D; Jug U; Mavri J; Stare J
[Ad] Endereço:Theory Department, National Institute of Chemistry, Ljubljana, Slovenia. jernej.stare@ki.si.
[Ti] Título:Why does the Y326I mutant of monoamine oxidase B decompose an endogenous amphetamine at a slower rate than the wild type enzyme? Reaction step elucidated by multiscale molecular simulations.
[So] Source:Phys Chem Chem Phys;20(6):4181-4188, 2018 Feb 07.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work investigates the Y326I point mutation effect on the kinetics of oxidative deamination of phenylethylamine (PEA) catalyzed by the monoamine oxidase B (MAO B) enzyme. PEA is a neuromodulator capable of affecting the plasticity of the brain and is responsible for the mood enhancing effect caused by physical exercise. Due to a similar functionality, PEA is often regarded as an endogenous amphetamine. The rate limiting step of the deamination was simulated at the multiscale level, employing the Empirical Valence Bond approach for the quantum treatment of the involved valence states, whereas the environment (solvated protein) was represented with a classical force field. A comparison of the reaction free energy profiles delivered by simulation of the reaction in the wild type MAO B and its Y326I mutant yields an increase in the barrier by 1.06 kcal mol upon mutation, corresponding to a roughly 6-fold decrease in the reaction rate. This is in excellent agreement with the experimental kinetic studies. Inspection of simulation trajectories reveals possible sources of the point mutation effect, namely vanishing favorable electrostatic interactions between PEA and a Tyr326 side chain and an increased amount of water molecules at the active site due to the replacement of tyrosine by a less spacious isoleucine residue, thereby increasing the dielectric shielding of the catalytic environment provided by the enzyme.
[Mh] Termos MeSH primário: Anfetamina/metabolismo
Monoaminoxidase/metabolismo
[Mh] Termos MeSH secundário: Anfetamina/química
Sítios de Ligação
Biocatálise
Domínio Catalítico
Desaminação
Cinética
Monoaminoxidase/química
Monoaminoxidase/genética
Fenetilaminas/química
Fenetilaminas/metabolismo
Mutação Puntual
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenethylamines); CK833KGX7E (Amphetamine); EC 1.4.3.4 (Monoamine Oxidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp07069a


  5 / 10765 MEDLINE  
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[PMID]:27771748
[Au] Autor:Leventhal AM; Kirkpatrick MG; Pester MS; McGeary JE; Swift RM; Sussman S; Kahler CW
[Ad] Endereço:Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, CSC 240, Los Angeles, 90033, CA, USA. adam.leventhal@usc.edu.
[Ti] Título:Pharmacogenetics of stimulant abuse liability: association of CDH13 variant with amphetamine response in a racially-heterogeneous sample of healthy young adults.
[So] Source:Psychopharmacology (Berl);234(2):307-315, 2017 Jan.
[Is] ISSN:1432-2072
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A previous genome-wide association study (GWAS) in a predominately Caucasian sample of healthy young adults linked greater amphetamine-induced rewarding effects with the rs3784943 G allele of the cadherin 13 (CDH13; i.e., a cell adhesion molecule implicated in neuronal connectivity) gene. This association has not been subsequently examined, nor has it been studied in Asian populations, which may have greater frequencies of the risk allele. OBJECTIVE: The objective of this study was to examine the association of rs3784943 with amphetamine response in a racially heterogeneous sample (37 % Asian) of healthy young adults. METHODS: Participants (N = 84; 18-35 years old) genotyped for rs3784943 completed counterbalanced sessions involving 20 mg oral d-amphetamine or placebo administration. At both sessions, cardiovascular and subjective drug effects measures were collected. RESULTS: In the combined racially heterogeneous sample, amphetamine (vs. placebo) effects were significantly greater on "Feel Drug" ratings (p < 0.05) and marginally greater on "Feel High" ratings and systolic blood pressure (p < 0.10) in G/A + G/G genotypes than A/A genotypes. The G allele was more common among Asian than other racial groups. Among the subsample of Asian participants (N = 31), drug effects were significantly greater on Feel Drug (p < 0.05) and marginally greater on Feel High and heart rate (p < 0.10) among Asians with G/A + G/G (vs. A/A) genotypes. CONCLUSIONS: In concert with a previous GWAS result, this candidate gene study provides convergent evidence implicating CDH13 rs3784943 variant in d-amphetamine's drug effect profile and suggests generalization to Asian populations. CDH13 and genes coding for other cell adhesion molecules may be worthy of study in the biology of psychostimulant abuse liability.
[Mh] Termos MeSH primário: Anfetamina/administração & dosagem
Caderinas/genética
Estimulantes do Sistema Nervoso Central/administração & dosagem
Grupos de Populações Continentais/genética
Farmacogenética/métodos
Variantes Farmacogenômicos/genética
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Pressão Sanguínea/efeitos dos fármacos
Pressão Sanguínea/genética
Método Duplo-Cego
Feminino
Estudo de Associação Genômica Ampla/métodos
Frequência Cardíaca/efeitos dos fármacos
Frequência Cardíaca/genética
Seres Humanos
Masculino
Variantes Farmacogenômicos/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cadherins); 0 (Central Nervous System Stimulants); 0 (H-cadherin); CK833KGX7E (Amphetamine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1007/s00213-016-4462-z


  6 / 10765 MEDLINE  
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[PMID]:28936885
[Au] Autor:Angeli A; Vaiano F; Mari F; Bertol E; Supuran CT
[Ad] Endereço:a Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.
[Ti] Título:Psychoactive substances belonging to the amphetamine class potently activate brain carbonic anhydrase isoforms VA, VB, VII, and XII.
[So] Source:J Enzyme Inhib Med Chem;32(1):1253-1259, 2017 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Identifying possible new biological activities of psychoactive substances belonging to various chemical classes may lead to a better understanding of their mode of action and side effects. We report here that amines structurally related to amphetamine, a widely used psychoactive substance, such as amphetamine, methamphetamine, phentermine, mephentermine, and chlorphenteramine, potently activate several carbonic anhydrase (CA, EC 4.2.1.1) isoforms involved in important physiological functions. Of the 11 investigated human (h) isoforms, the widespread hCA I and II, the secreted hCA VI, as well as the cytosolic hCA XIII, and membrane-bound hCA IX and XIV were poorly activated by these amines, whereas the extracellular hCA IV, the mitochondrial enzymes hCA VA/VB, the cytosolic hCA VII, and the transmembrane isoform hCA XII were potently activated. Some of these enzymes are abundant in the brain, raising the possibility that some of the cognitive effects of such psychoactive substances might be related to their activation of these enzymes.
[Mh] Termos MeSH primário: Anfetamina/classificação
Anfetamina/farmacologia
Encéfalo/enzimologia
Anidrases Carbônicas/metabolismo
Psicotrópicos/classificação
Psicotrópicos/farmacologia
[Mh] Termos MeSH secundário: Anfetamina/química
Relação Dose-Resposta a Droga
Ativação Enzimática/efeitos dos fármacos
Seres Humanos
Isoenzimas/metabolismo
Modelos Moleculares
Estrutura Molecular
Psicotrópicos/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoenzymes); 0 (Psychotropic Drugs); CK833KGX7E (Amphetamine); EC 4.2.1.1 (Carbonic Anhydrases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1375485


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[PMID]:28922649
[Au] Autor:Lehmann S; Kieliba T; Beike J; Thevis M; Mercer-Chalmers-Bender K
[Ad] Endereço:Institute of Legal Medicine, Medical Faculty, University of Cologne, Cologne, Germany.
[Ti] Título:Determination of 74 new psychoactive substances in serum using automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1064:124-138, 2017 Oct 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A detailed description is given of the development and validation of a fully automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) method capable of detecting 90 central-stimulating new psychoactive substances (NPS) and 5 conventional amphetamine-type stimulants (amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA), methamphetamine) in serum. The aim was to apply the validated method to forensic samples. The preparation of 150µL of serum was performed by an Instrument Top Sample Preparation (ITSP)-SPE with mixed mode cation exchanger cartridges. The extracts were directly injected into an LC-MS/MS system, using a biphenyl column and gradient elution with 2mM ammonium formate/0.1% formic acid and acetonitrile/0.1% formic acid as mobile phases. The chromatographic run time amounts to 9.3min (including re-equilibration). The total cycle time is 11min, due to the interlacing between sample preparation and analysis. The method was fully validated using 69 NPS and five conventional amphetamine-type stimulants, according to the guidelines of the Society of Toxicological and Forensic Chemistry (GTFCh). The guidelines were fully achieved for 62 analytes (with a limit of detection (LOD) between 0.2 and 4µg/L), whilst full validation was not feasible for the remaining 12 analytes. For the fully validated analytes, the method achieved linearity in the 5µg/L (lower limit of quantification, LLOQ) to 250µg/L range (coefficients of determination>0.99). Recoveries for 69 of these compounds were greater than 50%, with relative standard deviations≤15%. The validated method was then tested for its capability in detecting a further 21 NPS, thus totalling 95 tested substances. An LOD between 0.4 and 1.6µg/L was obtained for these 21 additional qualitatively-measured substances. The method was subsequently successfully applied to 28 specimens from routine forensic case work, of which 7 samples were determined to be positive for NPS consumption.
[Mh] Termos MeSH primário: Psicotrópicos/sangue
Detecção do Abuso de Substâncias/métodos
[Mh] Termos MeSH secundário: Adulto
Anfetamina/sangue
Cromatografia Líquida/métodos
Cocaína/sangue
Seres Humanos
Ketamina/sangue
Limite de Detecção
Modelos Lineares
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Extração em Fase Sólida/métodos
Espectrometria de Massas em Tandem/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Psychotropic Drugs); 690G0D6V8H (Ketamine); CK833KGX7E (Amphetamine); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28881029
[Au] Autor:Berezniuk I; Rodriguiz RM; Zee ML; Marcus DJ; Pintar J; Morgan DJ; Wetsel WC; Fricker LD
[Ad] Endereço:Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
[Ti] Título:ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.
[So] Source:J Neurochem;143(3):268-281, 2017 Nov.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To identify neuropeptides that are regulated by cocaine, we used a quantitative peptidomic technique to examine the relative levels of neuropeptides in several regions of mouse brain following daily intraperitoneal administration of 10 mg/kg cocaine or saline for 7 days. A total of 102 distinct peptides were identified in one or more of the following brain regions: nucleus accumbens, caudate putamen, frontal cortex, and ventral tegmental area. None of the peptides detected in the caudate putamen or frontal cortex were altered by cocaine administration. Three peptides in the nucleus accumbens and seven peptides in the ventral tegmental area were significantly decreased in cocaine-treated mice. Five of these ten peptides are derived from proSAAS, a secretory pathway protein and neuropeptide precursor. To investigate whether proSAAS peptides contribute to the physiological effects of psychostimulants, we examined acute responses to cocaine and amphetamine in the open field with wild-type (WT) and proSAAS knockout (KO) mice. Locomotion was stimulated more robustly in the WT compared to mutant mice for both psychostimulants. Behavioral sensitization to amphetamine was not maintained in proSAAS KO mice and these mutants failed to sensitize to cocaine. To determine whether the rewarding effects of cocaine were altered, mice were tested in conditioned place preference (CPP). Both WT and proSAAS KO mice showed dose-dependent CPP to cocaine that was not distinguished by genotype. Taken together, these results suggest that proSAAS-derived peptides contribute differentially to the behavioral sensitization to psychostimulants, while the rewarding effects of cocaine appear intact in mice lacking proSAAS.
[Mh] Termos MeSH primário: Cocaína/farmacologia
Inibidores da Captação de Dopamina/farmacologia
Hipercinese/induzido quimicamente
Locomoção/efeitos dos fármacos
Proteínas do Tecido Nervoso/metabolismo
[Mh] Termos MeSH secundário: Anfetamina/farmacologia
Animais
Condicionamento Operante/efeitos dos fármacos
Relação Dose-Resposta a Droga
Comportamento Exploratório/efeitos dos fármacos
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/genética
Masculino
Espectrometria de Massas
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Proteínas do Tecido Nervoso/genética
Núcleo Accumbens/efeitos dos fármacos
Área Tegmentar Ventral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dopamine Uptake Inhibitors); 0 (Nerve Tissue Proteins); 0 (Pcsk1n protein, mouse); CK833KGX7E (Amphetamine); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14209


  9 / 10765 MEDLINE  
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[PMID]:28863334
[Au] Autor:El-Beqqali A; Andersson LI; Jeppsson AD; Abdel-Rehim M
[Ad] Endereço:Department of Environmental Sci. & Analytical Chemistry, Stockholm University, SE10691 Stockholm, Sweden.
[Ti] Título:Molecularly imprinted polymer-sol-gel tablet toward micro-solid phase extraction: II. Determination of amphetamine in human urine samples by liquid chromatography-tandem mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:130-135, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Amphetamine selective molecularly imprinted sol-gel polymer tablets, MIP-tablets, for solid-phase microextraction of biofluid samples were prepared. An acetonitrile solution of deuterated amphetamine template and silane precursor, 3-(propylmethacrylate) trimethoxysilane, was soaked into the pores of polyethylene tablet substrates and polymerized by an acid-catalysed sol-gel process. Application of the resultant MIP-tablets to extract amphetamine from human urine samples followed by LC-MS/MS analysis was investigated. The extraction protocol was optimised with respect to pH of sample, addition of sodium chloride, extraction time, desorption solvent and desorption time. The final analysis method determined amphetamine in human urine with a limit of detection (LOD) of 1.0ng/mL and a lower limit of quantification (LLOQ) of 5ng/mL. Validation demonstrated accuracy of the method was 91.0-104.0% and inter-assay precision was 4.8-8.5% (RSD). Extraction recovery was 80%. The MIP-tablets could be re-used and the same tablet could be employed for more than twenty extractions.
[Mh] Termos MeSH primário: Anfetamina/química
Anfetamina/urina
Impressão Molecular/métodos
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Limite de Detecção
Modelos Lineares
Transição de Fase
Polímeros/química
Reprodutibilidade dos Testes
Comprimidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polymers); 0 (Tablets); CK833KGX7E (Amphetamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


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[PMID]:28853604
[Au] Autor:Green PA; Battersby C; Heath RM; McCrossan L
[Ad] Endereço:Royal Liverpool and Broadgreen University Hospitals NHS Trust , UK.
[Ti] Título:A fatal case of amphetamine induced ischaemic colitis.
[So] Source:Ann R Coll Surg Engl;99(7):e200-e201, 2017 Sep.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Amphetamine induced ischaemic colitis is an exceedingly rare presentation of amphetamine toxicity. The cases reported in the literature have described mild or transient disease. We present a fatal case of ischaemic colitis induced by amphetamine use in a 44-year-old woman who presented in extremis after a cardiac arrest en route to the emergency department. A short history of headache, abdominal pain, vomiting and agitation preceded her admission. Imaging revealed changes consistent with ischaemic colitis. Emergency laparotomy revealed widespread colonic necrosis necessitating a subtotal colectomy. Despite aggressive resuscitation and inotropic support from arrival, the patient deteriorated intraoperatively and died in the immediate postoperative period. Histology showed arterial type ischaemia/reperfusion injury of the area supplied by the superior mesenteric artery. The patient's serum amphetamine level was 0.52mg/l (peak therapeutic levels <0.2mg/l). The postmortem examination concluded that amphetamines were the likely cause of the vasospasm, leading to profound colonic ischaemia.
[Mh] Termos MeSH primário: Anfetamina/efeitos adversos
Colite Isquêmica/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Colectomia
Colite Isquêmica/complicações
Colite Isquêmica/cirurgia
Evolução Fatal
Feminino
Seres Humanos
Traumatismo por Reperfusão/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
CK833KGX7E (Amphetamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2016.0350



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