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[PMID]:29386447
[Au] Autor:Mori T; Sawaguchi T
[Ad] Endereço:Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences.
[Ti] Título:[Underlying Mechanisms of Methamphetamine-Induced Self-Injurious Behavior and Lethal Effects in Mice].
[So] Source:Nihon Eiseigaku Zasshi;73(1):51-56, 2018.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Relatively high doses of psychostimulants induce neurotoxicity on the dopaminergic system and self-injurious behavior (SIB) in rodents. However the underlying neuronal mechanisms of SIB remains unclear. Dopamine receptor antagonists, N-methyl-D-aspartic acid (NMDA) receptor antagonists, Nitric Oxide Synthase (NOS) inhibitors and free radical scavengers significantly attenuate methamphetamine-induced SIB. These findings indicate that activation of dopamine as well as NMDA receptors followed by radical formation and oxidative stress, especially when mediated by NOS activation, is associated with methamphetamine-induced SIB. On the other hand, an increase in the incidence of polydrug abuse is a major problem worldwide. Coadministered methamphetamine and morphine induced lethality in more than 80% in mice, accompanied by an increase in the number of poly (ADP-ribose) polymerase (PARP)-immunoreactive cells in the heart, kidney and liver. The lethal effect and the increase in the incidence of rupture or PARP-immunoreactive cells induced by the coadministration of methamphetamine and morphine were significantly attenuated by pretreatment with a phospholipase A2 inhibitor or a radical scavenger, or by cooling of body from 30 to 90 min after drug administration. These results suggest that free radicals play an important role in the increased lethality induced by the coadministration of methamphetamine and morphine. Therefore, free radical scavengers and cooling are beneficial for preventing death that is induced by the coadministration of methamphetamine and morphine. These findings may help us better understand for masochistic behavior, which is a clinical phenomenon on SIB, as well as polydrug-abuse-induced acute toxicity.
[Mh] Termos MeSH primário: Estimulantes do Sistema Nervoso Central/efeitos adversos
Estimulantes do Sistema Nervoso Central/toxicidade
Metanfetamina/efeitos adversos
Metanfetamina/toxicidade
Comportamento Autodestrutivo/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Antagonistas de Dopamina/farmacologia
Antagonistas de Dopamina/uso terapêutico
Neurônios Dopaminérgicos/efeitos dos fármacos
Relação Dose-Resposta a Droga
Interações Medicamentosas
Depuradores de Radicais Livres/farmacologia
Depuradores de Radicais Livres/uso terapêutico
Radicais Livres/efeitos adversos
Radicais Livres/toxicidade
Seres Humanos
Dose Letal Mediana
Metanfetamina/administração & dosagem
Morfina/administração & dosagem
Morfina/efeitos adversos
Morfina/toxicidade
Receptores de N-Metil-D-Aspartato/antagonistas & inibidores
Comportamento Autodestrutivo/etiologia
Transtornos Relacionados ao Uso de Substâncias
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 0 (Dopamine Antagonists); 0 (Free Radical Scavengers); 0 (Free Radicals); 0 (Receptors, N-Methyl-D-Aspartate); 44RAL3456C (Methamphetamine); 76I7G6D29C (Morphine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.73.51


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[PMID]:27776672
[Au] Autor:Hellem TL
[Ad] Endereço:Montana State University College of Nursing, Missoula, MT 59812-7416, United States. Electronic address: tracy.hellem1@montana.edu.
[Ti] Título:A Review of Methamphetamine Dependence and Withdrawal Treatment: A Focus on Anxiety Outcomes.
[So] Source:J Subst Abuse Treat;71:16-22, 2016 12.
[Is] ISSN:1873-6483
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rates of anxiety disorders among individuals who use methamphetamine are estimated to be as high as 30.2%. The presence of an anxiety disorder in methamphetamine users is associated with higher rates of relapse, non-adherence to treatment and poorer outcomes relative to methamphetamine users without an anxiety disorder. A review investigating current treatment options for methamphetamine dependence or withdrawal from methamphetamine was conducted using PubMed, CINAHL and PsycINFO. The focus of the review was trials that utilized an intervention and collected anxiety as an outcome measure. Seven studies were included in the review, and five of these studies examined a pharmacotherapy option, one studied a psychosocial intervention and one study investigated exercise as an intervention. Some of the pharmacotherapy studies and the study of exercise were associated with improvements in mood and/or a reduction in methamphetamine use. Concerns of sample size and measurement of anxiety were raised. Future well-designed research with large sample sizes is warranted to examine how to manage anxiety among methamphetamine users.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/terapia
Transtornos de Ansiedade
Estimulantes do Sistema Nervoso Central
Metanfetamina
Avaliação de Resultados (Cuidados de Saúde)
Síndrome de Abstinência a Substâncias/terapia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29293553
[Au] Autor:Persons AL; Bradaric BD; Dodiya HB; Ohene-Nyako M; Forsyth CB; Keshavarzian A; Shaikh M; Napier TC
[Ad] Endereço:Department of Psychiatry, Rush University Medical Center, Chicago, IL, United States of America.
[Ti] Título:Colon dysregulation in methamphetamine self-administering HIV-1 transgenic rats.
[So] Source:PLoS One;13(1):e0190078, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The integrity and function of the gut is impaired in HIV-infected individuals, and gut pathogenesis may play a role in several HIV-associated disorders. Methamphetamine is a popular illicit drug abused by HIV-infected individuals. However, the effect of methamphetamine on the gut and its potential to exacerbate HIV-associated gut pathology is not known. To shed light on this scenario, we evaluated colon barrier pathology in a rat model of the human comorbid condition. Intestinal barrier integrity and permeability were assessed in drug-naïve Fischer 344 HIV-1 transgenic (Tg) and non-Tg rats, and in Tg and non-Tg rats instrumented with jugular cannulae trained to self-administer methamphetamine or serving as saline-yoked controls. Intestinal permeability was determined by measuring the urine content of orally gavaged sugars. Intestinal barrier integrity was evaluated by immunoblotting or immunofluorescence of colon claudin-1 and zonula occludens-1 (ZO-1), two major tight junction proteins that regulate gut epithelial paracellular permeability. Both non-Tg and Tg rats self-administered moderate amounts of methamphetamine. These amounts were sufficient to increase colon permeability, reduce protein level of claudin-1, and reduce claudin-1 and ZO-1 immunofluorescence in Tg rats relative to non-Tg rats. Methamphetamine decreased tight junction immunofluorescence in non-Tg rats, with a similar, but non-significant trend observed in Tg rats. However, the effect of methamphetamine on tight junction proteins was subthreshold to gut leakiness. These findings reveal that both HIV-1 proteins and methamphetamine alter colon barrier integrity, and indicate that the gut may be a pathogenic site for these insults.
[Mh] Termos MeSH primário: Colo/fisiopatologia
Infecções por HIV/fisiopatologia
HIV-1/genética
Metanfetamina/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Genótipo
Infecções por HIV/complicações
Mucosa Intestinal/fisiopatologia
Masculino
Ratos
Ratos Endogâmicos F344
Ratos Transgênicos
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190078


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[PMID]:29202872
[Au] Autor:Mburu G; Ngin C; Tuot S; Chhoun P; Pal K; Yi S
[Ad] Endereço:Division of Health Research, Lancaster University, Lancaster, UK.
[Ti] Título:Patterns of HIV testing, drug use, and sexual behaviors in people who use drugs: findings from a community-based outreach program in Phnom Penh, Cambodia.
[So] Source:Addict Sci Clin Pract;12(1):27, 2017 Dec 05.
[Is] ISSN:1940-0640
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: People who use drugs are an important priority for HIV programs. However, data related to their utilization of HIV services are limited. This paper reports patterns of HIV testing, drug use, and risk and service perception among people who use drugs. Study participants were receiving HIV and harm reduction services from a community-based program in Phnom Penh, comprised of itinerant peer-led outreach and static drop-in centers. METHODS: This was a mixed-methods study conducted in 2014, comprising of a quantitative survey using a structured questionnaire, followed by two focus group discussions among a sub-sample of survey participants. Participants were recruited from hotspots in five HIV high-burden communes using a two-stage cluster sampling method. Quantitative descriptive analyses and qualitative thematic analyses were performed. RESULTS: This study included 151 people who use drugs with a mean age of 31.2 (SD = 6.5) years; 77.5% were male and 39.1% were married. The most common drugs used were methamphetamines (72.8%) and heroin (39.7%), and 38.0% injected drugs in the past 3 months. Overall, 83.3% had been tested for HIV in the past 6 months, of whom 62.5% had been tested by peers through community-based outreach. However, there were ongoing HIV risks: 37.3% were engaging in sex on drugs, only 35.6% used a condom at last sexual intercourse, and 10.8% had had a sexually transmitted infection in the last 6 months. Among people who reported injecting drugs in the past 3 months, 27.5% reported re-using needles/syringes. Almost half (46.5%) perceived themselves as being at lower risk of HIV compared to the general population. Qualitative results contextualized the findings of low perception of HIV risks and suggested that although services were often unavailable on weekends, at night, or during national holidays, peer-led community-based outreach was highly accepted. CONCLUSIONS: A peer-led community-based approach was effective in reaching people who use drugs with HIV and harm reduction interventions. To mitigate ongoing HIV risks, expanding access to combination prevention interventions and implementing strategies to enable people who use drugs to objectively assess their HIV risks are required. Additionally, community-based programs should collect data along the care continuum, to enable decentralized tracking of progress towards 90-90-90 goals at local levels.
[Mh] Termos MeSH primário: Infecções por HIV/prevenção & controle
Dependência de Heroína/prevenção & controle
Assunção de Riscos
Comportamento Sexual/estatística & dados numéricos
Abuso de Substâncias por Via Intravenosa/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Camboja
Relações Comunidade-Instituição
Feminino
Infecções por HIV/complicações
Dependência de Heroína/complicações
Seres Humanos
Masculino
Metanfetamina/efeitos adversos
Fatores de Risco
Abuso de Substâncias por Via Intravenosa/complicações
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s13722-017-0094-9


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[PMID]:28448903
[Au] Autor:Argento E; Strathdee SA; Goldenberg S; Braschel M; Montaner J; Shannon K
[Ad] Endereço:Gender and Sexual Health Initiative, BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada; Interdisciplinary Studies Graduate Program, University of British Columbia, 2357 Main Mall, Vancouver, BC, V6T 1Z4, Canada.
[Ti] Título:Violence, trauma and living with HIV: Longitudinal predictors of initiating crystal methamphetamine injection among sex workers.
[So] Source:Drug Alcohol Depend;175:198-204, 2017 06 01.
[Is] ISSN:1879-0046
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access). Participants completed bi-annual interviewer-administered questionnaires and HIV/STI testing. Kaplan Meier methods and Cox proportional hazards regression were used to model predictors of CM injection initiation among CM injection-naïve participants. RESULTS: Of 455 participants eligible at baseline, 14.3% (n=65) injected CM for the first time over follow-up, with an incidence density of 6.79 per 100 person-years (95% Confidence Interval [CI] 5.30-8.69). In multivariable analysis, injection heroin use (Adjusted Hazard Ratio [AHR] 6.11; 95%CI 3.24-11.52), having an intimate partner who injects drugs (AHR 2.93; 95%CI 1.57-5.46), workplace violence (AHR 2.85; 95%CI 1.74-4.67), HIV seropositivity (AHR 2.69; 95%CI 1.45-5.00), and childhood abuse (AHR 1.86; 95%CI 0.99-3.49) were independently associated with initiating CM injection. CONCLUSIONS: Findings underscore the gendered and social risk environment of CM injection initiation among sex workers. The strong influences of historical/workplace violence, coupled with heroin injection (known to be self-medicating for post-traumatic stress) as a primary risk pathway, emphasize the urgency of increasing access to integrated, trauma-informed addiction treatment and HIV care for marginalized women.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/psicologia
Infecções por HIV/psicologia
Profissionais do Sexo/psicologia
Abuso de Substâncias por Via Intravenosa/psicologia
Violência/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Colúmbia Britânica
Estudos de Coortes
Feminino
Seres Humanos
Incidência
Injeções/psicologia
Estudos Longitudinais
Metanfetamina/administração & dosagem
Modelos de Riscos Proporcionais
Comportamento Sexual/psicologia
Parceiros Sexuais/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:29251898
[Au] Autor:Stone A
[Ti] Título:LITERATURE SEARCH: STI SCREENING AND DRUG USE IN YOUNG PEOPLE.
[So] Source:Aust Nurs Midwifery J;24(6):44, 2016 Dec.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Alcohol and other drug use are almost synonymous with increased risky sexual activity in young people (12-25 years). There is a direct correlation between initiation into methamphetamine use and an increase in sexual risk behaviours (Hoenigl et al. 2015).
[Mh] Termos MeSH primário: Metanfetamina/efeitos adversos
Assunção de Riscos
Doenças Sexualmente Transmissíveis/enfermagem
Transtornos Relacionados ao Uso de Substâncias/enfermagem
Sexo sem Proteção
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29024664
[Au] Autor:Venniro M; Caprioli D; Zhang M; Whitaker LR; Zhang S; Warren BL; Cifani C; Marchant NJ; Yizhar O; Bossert JM; Chiamulera C; Morales M; Shaham Y
[Ad] Endereço:Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, Baltimore, MD, USA. Electronic address: venniro.marco@nih.gov.
[Ti] Título:The Anterior Insular Cortex→Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management.
[So] Source:Neuron;96(2):414-427.e8, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts is contingency management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence. However, when contingency management is discontinued, most addicts relapse to drug use. The brain mechanisms underlying relapse after cessation of contingency management are largely unknown, and, until recently, an animal model of this human condition did not exist. Here we used a novel rat model, in which the availability of a mutually exclusive palatable food maintains prolonged voluntary abstinence from intravenous methamphetamine self-administration, to demonstrate that the activation of monosynaptic glutamatergic projections from anterior insular cortex to central amygdala is critical to relapse after the cessation of contingency management. We identified the anterior insular cortex-to-central amygdala projection as a new addiction- and motivation-related projection and a potential target for relapse prevention.
[Mh] Termos MeSH primário: Comportamento Aditivo/psicologia
Núcleo Central da Amígdala/fisiologia
Córtex Cerebral/fisiologia
Ingestão de Alimentos/fisiologia
Ingestão de Alimentos/psicologia
Metanfetamina/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Núcleo Central da Amígdala/efeitos dos fármacos
Córtex Cerebral/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Injeções Intravenosas
Masculino
Vias Neurais/efeitos dos fármacos
Vias Neurais/fisiologia
Ratos
Ratos Sprague-Dawley
Recidiva
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


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[PMID]:28850888
[Au] Autor:Haeri SA; Abbasi S; Sajjadifar S
[Ad] Endereço:Department of Chemistry, Faculty of Science, Ilam University, 69315-516, Ilam, Iran. Electronic address: haeriammar@yahoo.com.
[Ti] Título:Bio-dispersive liquid liquid microextraction based on nano rhaminolipid aggregates combined with magnetic solid phase extraction using Fe O @PPy magnetic nanoparticles for the determination of methamphetamine in human urine.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:101-106, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the present investigation, extraction and preconcentration of methamphetamine in human urine samples was carried out using a novel bio-dispersive liquid liquid microextraction (Bio-DLLME) technique coupled with magnetic solid phase extraction (MSPE). Bio-DLLME is a kind of microextraction technique based nano-materials which have potential capabilities in many application fields. Bio-DLLME is based on the use of a binary part system consisting of methanol and nano rhaminolipid biosurfactant. Use of this binary mixture is ecologically accepted due to their specificity, biocompatibility and biodegradable nature. The potential of nano rhaminolipid biosurfactant as a biological agent in the extraction of organic compounds has been investigated in recent years. They are able to partition at the oil/water interfaces and reduce the interfacial tension in order to increase solubility of hydrocarbons. The properties of the prepared Fe O @PPy magnetic nanoparticles were characterized using Fourier transform infrared spectroscopy and X-ray diffraction methods The influences of the experimental parameters on the quantitative recovery of analyte were investigated. Under optimized conditions, the enrichment factor was 310, the calibration graph was linear in the methamphetamine concentration range from 1 to 60µgL , with a correlation coefficient of 0.9998. The relative standard deviations for six replicate measurements was 5.2%.
[Mh] Termos MeSH primário: Glicolipídeos/química
Microextração em Fase Líquida/métodos
Nanopartículas de Magnetita/química
Metanfetamina/urina
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Limite de Detecção
Modelos Lineares
Masculino
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycolipids); 0 (Magnetite Nanoparticles); 0 (rhamnolipid); 44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


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[PMID]:28792619
[Au] Autor:Bowyer JF; Tranter KM; Sarkar S; George NI; Hanig JP; Kelly KA; Michalovicz LT; Miller DB; O'Callaghan JP
[Ad] Endereço:Division of Neurotoxicology, National Center for Toxicology/FDA, Jefferson, Arkansas, USA.
[Ti] Título:Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine.
[So] Source:J Neurochem;143(2):198-213, 2017 Oct.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Our previous studies have raised the possibility that altered blood glucose levels may influence and/or be predictive of methamphetamine (METH) neurotoxicity. This study evaluated the effects of exogenous glucose and corticosterone (CORT) pretreatment alone or in combination with METH on blood glucose levels and the neural and vascular toxicity produced. METH exposure consisted of four sequential injections of 5, 7.5, 10, and 10 mg/kg (2 h between injections) D-METH. The three groups given METH in combination with saline, glucose (METH+Glucose), or CORT (METH+CORT) had significantly higher glucose levels compared to the corresponding treatment groups without METH except at 3 h after the last injection. At this last time point, the METH and METH+Glucose groups had lower levels than the non-METH groups, while the METH+CORT group did not. CORT alone or glucose alone did not significantly increase blood glucose. Mortality rates for the METH+CORT (40%) and METH+Glucose (44%) groups were substantially higher than the METH (< 10%) group. Additionally, METH+CORT significantly increased neurodegeneration above the other three METH treatment groups (≈ 2.5-fold in the parietal cortex). Thus, maintaining elevated levels of glucose during METH exposure increases lethality and may exacerbate neurodegeneration. Neuroinflammation, specifically microglial activation, was associated with degenerating neurons in the parietal cortex and thalamus after METH exposure. The activated microglia in the parietal cortex were surrounding vasculature in most cases and the extent of microglial activation was exacerbated by CORT pretreatment. Our findings show that acute CORT exposure and elevated blood glucose levels can exacerbate METH-induced vascular damage, neuroinflammation, neurodegeneration and lethality. Cover Image for this issue: doi. 10.1111/jnc.13819.
[Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos
Corticosterona/toxicidade
Glucose/toxicidade
Metanfetamina/toxicidade
Lobo Parietal/efeitos dos fármacos
Tálamo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Corticosterona/administração & dosagem
Combinação de Medicamentos
Glucose/administração & dosagem
Masculino
Metanfetamina/administração & dosagem
Microglia/efeitos dos fármacos
Microglia/metabolismo
Lobo Parietal/irrigação sanguínea
Lobo Parietal/metabolismo
Ratos
Ratos Sprague-Dawley
Tálamo/irrigação sanguínea
Tálamo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Drug Combinations); 44RAL3456C (Methamphetamine); IY9XDZ35W2 (Glucose); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14143


  10 / 7888 MEDLINE  
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[PMID]:28715162
[Au] Autor:Drug Enforcement Administration, Department of Justice
[Ti] Título:Designation of Alpha-Phenylacetoacetonitrile (APAAN), a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine, as a List I Chemical. Final rule.
[So] Source:Fed Regist;82(134):32457-61, 2017 Jul 14.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Drug Enforcement Administration (DEA) is finalizing the designation of the chemical alpha-phenylacetoacetonitrile (APAAN) and its salts, optical isomers, and salts of optical isomers, as a list I chemical under the Controlled Substances Act (CSA). The DEA proposed control of APAAN, due to its use in clandestine laboratories to illicitly manufacture the schedule II controlled substances phenylacetone (also known as phenyl-2-propanone or P2P), methamphetamine, and amphetamine. This rulemaking finalizes, without change, the control of APAAN as a list I chemical. This action does not establish a threshold for domestic and international transactions of APAAN. As such, all transactions involving APAAN, regardless of size, shall be regulated. In addition, chemical mixtures containing APAAN are not exempt from regulatory requirements at any concentration. Therefore, all transactions of chemical mixtures containing any quantity of APAAN shall be regulated pursuant to the CSA. However, manufacturers may submit an application for exemption for those mixtures that do not qualify for automatic exemption.
[Mh] Termos MeSH primário: Acetonitrilos/classificação
Controle de Medicamentos e Entorpecentes/legislação & jurisprudência
[Mh] Termos MeSH secundário: Acetona/análise
Acetona/provisão & distribuição
Acetonitrilos/análise
Anfetamina/análise
Seres Humanos
Metanfetamina/análise
Drogas Ilícitas
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Street Drugs); 1364PS73AF (Acetone); 44RAL3456C (Methamphetamine); CK833KGX7E (Amphetamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE



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