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[PMID]:27992004
[Au] Autor:Teive HA; Germiniani FM; Kowacs PA; Munhoz RP
[Ad] Endereço:Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Medicina Interna, Serviço de Neurologia, Unidade de Distúrbios dos Movimentos, Curitiba PR, Brasil.
[Ti] Título:Charcot, Mitchell and Lees: neurology free thinkers and their experiences of psychoactive drugs.
[So] Source:Arq Neuropsiquiatr;74(12):1035-1038, 2016 Dec.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Three world-famous neurologists, Charcot and Mitchell, in the 19th century, and Lees, in this century, all of whom had great scientific curiosity, experimented with the psychoactive drugs hashish, mescal and yagé, respectively, in an attempt to increase their knowledge of neurological diseases and how the brain works.
[Mh] Termos MeSH primário: Neurologia/história
Psicotrópicos/história
[Mh] Termos MeSH secundário: Cannabis
Inglaterra
França
História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
Mescalina/história
Mescalina/uso terapêutico
Doenças do Sistema Nervoso/tratamento farmacológico
Psicotrópicos/uso terapêutico
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Charcot JM; Mitchell SW; Lees AJ
[Nm] Nome de substância:
0 (Psychotropic Drugs); RHO99102VC (Mescaline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE


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[PMID]:27882883
[Au] Autor:Ramesh Babu A; Raju G; Purna Chander C; Shoban Babu B; Srinivas R; Sharma GV
[Ad] Endereço:National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
[Ti] Título:Electrospray ionization tandem mass spectrometric study of protonated and alkali- cationized α/ε-hybrid peptides: differentiation of a pair of dipeptide positional isomers.
[So] Source:Eur J Mass Spectrom (Chichester);22(4):181-191, 2016.
[Is] ISSN:1469-0667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new class of Boc-N-protected hybrid peptides derived from L- Ala and ε -Caa (L-Ala = L-Alanine, Caa = C-linked carboamino acid derived from D-xylose) have been studied by positive ion electrospray ionization (ESI) ion-trap tandem mass spectrometry (MS/MS). MS spectra of protonated and alkali-cationized hybrid peptides produce characteristic fragmentation involving the peptide backbone, the tert-butyloxycarbonyl (Boc) group, and the side chain. The dipeptide positional isomers are differentiated by the collision-induced dissociation (CID) of the protonated and alkali-cationized peptides. The CID of [M + H] ion of Boc-NH-L-Ala-ε-Caa- OCH (1) shows a prominent [M + H - C H ] ion, which is totally absent for its positional isomer Boc-NH-ε-Caa-L-Ala-OCH (6), which instead shows significant loss of t-butanol. The formation of the [M + Cat - C H ] ion is totally absent and [M + Cat - Boc + H] is prominent in the CID of the [M + Cat] ion of Boc-NH-L-Ala-ε-Caa- OCH (1), whereas the former is highly abundant and the latter is of low abundance for its positional isomer Boc-NH-ε-Caa-L-Ala-OCH (6). It is observed that 'b' ions are abundant when oxazolone structures are formed through a five-membered cyclic transition state in tetra-, penta-, and hexapeptides and the cyclization process for larger 'b' ions led to an insignificant abundance. However, the significant 'b' ion is formed in ε,α-dipeptide, which may have a seven-membered substituted 2-oxoazepanium ion structure. The MS spectra of [M + Cat - Boc + H] ions of these peptides are found to be significantly different to those of [M + H - Boc + H] ions. The CID spectra of [M + Cat - Boc + H] ions of peptide acids containing L-Ala at the C-terminus show an abundant N-terminal rearrangement ion, [b + 17 + Cat] , which is absent for the peptide acids containing ε-Caa at the C-terminus. Thus, the results of these hybrid peptides provide sequencing information, the structure of the cyclic intermediate involved in the formation of the rearrangement ion, and distinguish a pair of dipeptide positional isomers.
[Mh] Termos MeSH primário: Álcalis/química
Dipeptídeos/análise
Dipeptídeos/química
Espectrometria de Massas por Ionização por Electrospray/métodos
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Cátions
Mescalina
Prótons
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkalies); 0 (Cations); 0 (Dipeptides); 0 (Protons); 3937-16-4 (isomescaline); RHO99102VC (Mescaline)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE


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[PMID]:26330142
[Au] Autor:Ibarra-Laclette E; Zamudio-Hernández F; Pérez-Torres CA; Albert VA; Ramírez-Chávez E; Molina-Torres J; Fernández-Cortes A; Calderón-Vázquez C; Olivares-Romero JL; Herrera-Estrella A; Herrera-Estrella L
[Ad] Endereço:Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados del IPN, 36500, Irapuato, Guanajuato, México. enrique.ibarra@inecol.mx.
[Ti] Título:De novo sequencing and analysis of Lophophora williamsii transcriptome, and searching for putative genes involved in mescaline biosynthesis.
[So] Source:BMC Genomics;16:657, 2015 Sep 02.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lophophora williamsii (commonly named peyote) is a small, spineless cactus with psychoactive alkaloids, particularly mescaline. Peyote utilizes crassulacean acid metabolism (CAM), an alternative form of photosynthesis that exists in succulents such as cacti and other desert plants. Therefore, its transcriptome can be considered an important resource for future research focused on understanding how these plants make more efficient use of water in marginal environments and also for research focused on better understanding of the overall mechanisms leading to production of plant natural products and secondary metabolites. RESULTS: In this study, two cDNA libraries were generated from L. williamsii. These libraries, representing buttons (tops of stems) and roots were sequenced using different sequencing platforms (GS-FLX, GS-Junior and PGM, respectively). A total of 5,541,550 raw reads were generated, which were assembled into 63,704 unigenes with an average length of 564.04 bp. A total of 25,149 unigenes (62.19 %) was annotated using public databases. 681 unigenes were found to be differentially expressed when comparing the two libraries, where 400 were preferentially expressed in buttons and 281 in roots. Some of the major alkaloids, including mescaline, were identified by GC-MS and relevant metabolic pathways were reconstructed using the Kyoto encyclopedia of genes and genomes database (KEGG). Subsequently, the expression patterns of preferentially expressed genes putatively involved in mescaline production were examined and validated by qRT-PCR. CONCLUSIONS: High throughput transcriptome sequencing (RNA-seq) analysis allowed us to efficiently identify candidate genes involved in mescaline biosynthetic pathway in L. williamsii; these included tyrosine/DOPA decarboxylase, hydroxylases, and O-methyltransferases. This study sets the theoretical foundation for bioassay design directed at confirming the participation of these genes in mescaline production.
[Mh] Termos MeSH primário: Genes de Plantas
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Mescalina/biossíntese
Sophora/genética
Transcriptoma/genética
[Mh] Termos MeSH secundário: Vias Biossintéticas/genética
Descarboxilação
Di-Hidroxifenilalanina/metabolismo
Hidroxilação
Funções Verossimilhança
Mescalina/química
Metiltransferases/metabolismo
Anotação de Sequência Molecular
Filogenia
Reação em Cadeia da Polimerase em Tempo Real
Reprodutibilidade dos Testes
Sophora/enzimologia
Tirosina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
42HK56048U (Tyrosine); 63-84-3 (Dihydroxyphenylalanine); EC 2.1.1.- (Methyltransferases); RHO99102VC (Mescaline)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150903
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-015-1821-9


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[PMID]:25992796
[Au] Autor:Battal D; Barnes AJ; Castaneto MS; Martin TM; Klette KL; Huestis MA
[Ad] Endereço:*Department of Toxicology, Faculty of Pharmacy, Mersin University, Turkey; †Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland; and ‡Drug Testing and Program Policy, Office of the Secretary of Defense, Operational Readiness and Safety, Washington, District of Columbia.
[Ti] Título:Urine Mescaline Screening With a Biochip Array Immunoassay and Quantification by Gas Chromatography-Mass Spectrometry.
[So] Source:Ther Drug Monit;37(6):805-11, 2015 Dec.
[Is] ISSN:1536-3694
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative for cannabinoids, cocaine, opiates, and amphetamines were tested for mescaline with the Randox Drugs of Abuse V (DOA-V) biochip array immunoassay at the manufacturer's recommended cutoff of 6 mcg/L. A sensitive and specific method for mescaline quantification in urine was developed and fully validated. Extracted analytes were derivatized with pentafluoropropionic anhydride and pentafluoropropanol and quantified by gas chromatography-mass spectrometry (GC/MS) with electron impact ionization. Standard curves, using linear least squares regression with 1/x weighting, were linear from 1 to 250 mcg/L with coefficients of determination >0.994. Intra- and inter-assay imprecision was <4.4 coefficient of variation (%CV), with accuracies >90.4%. Mean extraction efficiencies were >92.0% across the linear range. This fully validated method was applied for the confirmation of urinary mescaline in 526 presumptive-positive specimens and 198 randomly selected presumptive-negative specimens at the manufacturer's 6 mcg/L cutoff. No specimen confirmed positive at the GC/MS limit of quantification of 1 mcg/L. Results indicated that during this time frame, there was insufficient mescaline drug use in the military to warrant routine screening in the drug testing program. However, mescaline stability, although assessed, could have contributed to lower prevalence. We also present a validated GC/MS method for mescaline quantification in urine for reliable confirmation of suspected mescaline intake.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Mescalina/urina
Detecção do Abuso de Substâncias/métodos
Transtornos Relacionados ao Uso de Substâncias/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Imunoensaio/métodos
Limite de Detecção
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
RHO99102VC (Mescaline)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151113
[Lr] Data última revisão:
151113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150521
[St] Status:MEDLINE
[do] DOI:10.1097/FTD.0000000000000220


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[PMID]:25756723
[Au] Autor:Sjöstrand L
[Ti] Título:[Curiosity without borders. Aldous Huxley tried hallucinogens to look towards another world].
[Ti] Título:Nyfikenhet utan gränser--Aldous Huxley prövade hallucinogener för att rikta blicken mot en annan värld..
[So] Source:Lakartidningen;112, 2015 Mar 10.
[Is] ISSN:1652-7518
[Cp] País de publicação:Sweden
[La] Idioma:swe
[Mh] Termos MeSH primário: Alucinógenos/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
Dietilamida do Ácido Lisérgico/história
Mescalina/história
Filosofia
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Huxley A
[Nm] Nome de substância:
0 (Hallucinogens); 8NA5SWF92O (Lysergic Acid Diethylamide); RHO99102VC (Mescaline)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150312
[Lr] Data última revisão:
150312
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150311
[St] Status:MEDLINE


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[PMID]:25563446
[Au] Autor:Winkelman M
[Ad] Endereço:C.P. 62, Pirenopolis Goias, 72980-000 Brazil. He is retired from the School of Human Evolution and Social Change Arizona State University, USA. michaeljwinkelman@gmail.com.
[Ti] Título:Psychedelics as medicines for substance abuse rehabilitation: evaluating treatments with LSD, Peyote, Ibogaine and Ayahuasca.
[So] Source:Curr Drug Abuse Rev;7(2):101-16, 2014.
[Is] ISSN:1874-4745
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:Substances known as psychedelics, hallucinogens and entheogens have been employed in ethnomedical traditions for thousands of years, but after promising uses in the 1950's and 1960's they were largely prohibited in medical treatment and human research starting in the 1970's as part of the fallout from the war on drugs. Nonetheless, there are a number of studies which suggest that these substances have potential applications in the treatment of addictions. While these substances are generally classified as Schedule I, alleging no established medical uses and a high drug abuse potential, there is nonetheless evidence indicating they might be safe and effective tools for short term interventions in addictions treatment. Evidence suggests that the psychedelics have a much greater safety profile than the major addictive drugs, having extremely low levels of mortality, and producing little if any physical dependence. This paper reviews studies evaluating the use of LSD, peyote, ibogaine and ayahuasca in the treatment of dependencies and the possible mechanisms underlying the indications of effectiveness. Evidence suggests that these substances help assist recovery from drug dependency through a variety of therapeutic mechanisms, including a notable "after-glow" effect that in part reflects their action on the serotonin neurotransmitter system. Serotonin has been long recognized as central to the psychedelics' well-known phenomenological, physical, emotional and cognitive dynamics. These serotonin-based dynamics are directly relevant to treatment of addiction because of depressed serotonin levels found in addict populations, as well as the role of serotonin as a neuromodulators affecting many other neurotransmitter systems.
[Mh] Termos MeSH primário: Alucinógenos/administração & dosagem
Serotonina/metabolismo
Transtornos Relacionados ao Uso de Substâncias/reabilitação
[Mh] Termos MeSH secundário: Animais
Banisteriopsis/química
Alucinógenos/efeitos adversos
Alucinógenos/farmacologia
Seres Humanos
Ibogaína/administração & dosagem
Ibogaína/efeitos adversos
Ibogaína/farmacologia
Dietilamida do Ácido Lisérgico/administração & dosagem
Dietilamida do Ácido Lisérgico/efeitos adversos
Dietilamida do Ácido Lisérgico/farmacologia
Medicina Tradicional
Mescalina/administração & dosagem
Mescalina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hallucinogens); 333DO1RDJY (Serotonin); 3S814I130U (Ibogaine); 8NA5SWF92O (Lysergic Acid Diethylamide); RHO99102VC (Mescaline)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150203
[Lr] Data última revisão:
150203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150108
[St] Status:MEDLINE


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[PMID]:25187051
[Au] Autor:Prue B
[Ad] Endereço:University of Missouri-Kansas City, School of Social Work, Kansas City, Missouri.
[Ti] Título:Prevalence of reported peyote use 1985-2010 effects of the American Indian Religious Freedom Act of 1994.
[So] Source:Am J Addict;23(2):156-61, 2014 Mar-Apr.
[Is] ISSN:1521-0391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Peyote was classified as a hallucinogen in the Drug Abuse Control Act of 1965, leaving American Indian (AI) religious use in legal ambiguity. In 1994, the American Indian Religious Freedom Act was amended to unambiguously protect the right of religious use of peyote for AIs. OBJECTIVES: The purpose of this article is to report the prevalence rates of peyote use by AIs compared to the rest of the US population and to determine what effect the act's passage had on peyote use rates. METHODS: This investigation utilized an analysis of existing archived large nationally representative surveys of the American population. Data on peyote use rates was determined for most years 1985 through 2010. A total of 886,088 completed surveys were analyzed, of which 12,749 were from AIs. Use rates were triangulated using peyote harvest data. RESULTS AND CONCLUSIONS: Peyote use for AIs and the rest of the US population has remained stable between 1% and 2%. American Indian use rose dramatically in the 4 years following the AIRFA and leveled to just under 10%. The rapidity of the rise was excessive in light of the growth in the NAC and compared to the amounts of peyote stocks available. It is hypothesized that social desirability biases suppressed the Pre-AIRFA use rates due to peyote illegal status. SCIENTIFIC SIGNIFICANCE: Beyond describing peyote use rates and the effects of the AIRFA, this research adds to the body of evidence regarding the levels of under-reporting of illicit drugs.
[Mh] Termos MeSH primário: Direitos Civis/legislação & jurisprudência
Índios Norte-Americanos/legislação & jurisprudência
Mescalina
Religião
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
[Mh] Termos MeSH secundário: Coleta de Dados
Seres Humanos
Mescalina/administração & dosagem
Prevalência
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
RHO99102VC (Mescaline)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140905
[St] Status:MEDLINE
[do] DOI:10.1111/j.1521-0391.2013.12083.x


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[PMID]:24823967
[Au] Autor:Appendino G; Minassi A; Taglialatela-Scafati O
[Ad] Endereço:Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy. giovanni.appendino@pharm.unipmn.it.
[Ti] Título:Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs.
[So] Source:Nat Prod Rep;31(7):880-904, 2014 Jul.
[Is] ISSN:1460-4752
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Covering: up to December 2013. Over the past decade, there has been a growing transition in recreational drugs from natural materials (marijuana, hashish, opium), natural products (morphine, cocaine), or their simple derivatives (heroin), to synthetic agents more potent than their natural prototypes, which are sometimes less harmful in the short term, or that combine properties from different classes of recreational prototypes. These agents have been named smart drugs, and have become popular both for personal consumption and for collective intoxication at rave parties. The reasons for this transition are varied, but are mainly regulatory and commercial. New analogues of known illegal intoxicants are invisible to most forensic detection techniques, while the alleged natural status and the lack of avert acute toxicity make them appealing to a wide range of users. On the other hand, the advent of the internet has made possible the quick dispersal of information among users and the on-line purchase of these agents and/or the precursors for their synthesis. Unlike their natural products chemotypes (ephedrine, mescaline, cathinone, psilocybin, THC), most new drugs of abuse are largely unfamiliar to the organic chemistry community as well as to health care providers. To raise awareness of the growing plague of smart drugs we have surveyed, in a medicinal chemistry fashion, their development from natural products leads, their current methods of production, and the role that clandestine home laboratories and underground chemists have played in the surge of popularity of these drugs.
[Mh] Termos MeSH primário: Produtos Biológicos
Fármacos do Sistema Nervoso Central/síntese química
Descoberta de Drogas
Drogas Ilícitas
[Mh] Termos MeSH secundário: Alcaloides
Produtos Biológicos/química
Produtos Biológicos/farmacologia
Canabinoides
Fármacos do Sistema Nervoso Central/química
Fármacos do Sistema Nervoso Central/farmacologia
Efedrina
Mescalina
Estrutura Molecular
Drogas Ilícitas/síntese química
Drogas Ilícitas/química
Drogas Ilícitas/farmacologia
Triptaminas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Biological Products); 0 (Cannabinoids); 0 (Central Nervous System Agents); 0 (Street Drugs); 0 (Tryptamines); 422ZU9N5TV (tryptamine); 540EI4406J (cathinone); GN83C131XS (Ephedrine); RHO99102VC (Mescaline)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140612
[Lr] Data última revisão:
140612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140515
[St] Status:MEDLINE
[do] DOI:10.1039/c4np00010b


  9 / 804 MEDLINE  
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[PMID]:23976938
[Au] Autor:Krebs TS; Johansen PØ
[Ad] Endereço:Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
[Ti] Título:Psychedelics and mental health: a population study.
[So] Source:PLoS One;8(8):e63972, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The classical serotonergic psychedelics LSD, psilocybin, mescaline are not known to cause brain damage and are regarded as non-addictive. Clinical studies do not suggest that psychedelics cause long-term mental health problems. Psychedelics have been used in the Americas for thousands of years. Over 30 million people currently living in the US have used LSD, psilocybin, or mescaline. OBJECTIVE: To evaluate the association between the lifetime use of psychedelics and current mental health in the adult population. METHOD: Data drawn from years 2001 to 2004 of the National Survey on Drug Use and Health consisted of 130,152 respondents, randomly selected to be representative of the adult population in the United States. Standardized screening measures for past year mental health included serious psychological distress (K6 scale), mental health treatment (inpatient, outpatient, medication, needed but did not receive), symptoms of eight psychiatric disorders (panic disorder, major depressive episode, mania, social phobia, general anxiety disorder, agoraphobia, posttraumatic stress disorder, and non-affective psychosis), and seven specific symptoms of non-affective psychosis. We calculated weighted odds ratios by multivariate logistic regression controlling for a range of sociodemographic variables, use of illicit drugs, risk taking behavior, and exposure to traumatic events. RESULTS: 21,967 respondents (13.4% weighted) reported lifetime psychedelic use. There were no significant associations between lifetime use of any psychedelics, lifetime use of specific psychedelics (LSD, psilocybin, mescaline, peyote), or past year use of LSD and increased rate of any of the mental health outcomes. Rather, in several cases psychedelic use was associated with lower rate of mental health problems. CONCLUSION: We did not find use of psychedelics to be an independent risk factor for mental health problems.
[Mh] Termos MeSH primário: Alucinógenos/farmacologia
Dietilamida do Ácido Lisérgico/farmacologia
Saúde Mental/estatística & dados numéricos
Mescalina/farmacologia
Psilocibina/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Coleta de Dados/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Transtornos Mentais/epidemiologia
Transtornos Mentais/fisiopatologia
Meia-Idade
Razão de Chances
Fatores de Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hallucinogens); 2RV7212BP0 (Psilocybin); 8NA5SWF92O (Lysergic Acid Diethylamide); RHO99102VC (Mescaline)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130827
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0063972


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[PMID]:22900815
[Au] Autor:Gambelunghe C; Marsili R; Aroni K; Bacci M; Rossi R
[Ad] Endereço:Department of Clinical and Experimental Medicine, Division of Legal and Sports Medicine, University of Perugia, Padiglione W, via E. dal Pozzo, 06123, Perugia, Italy. cristiana.gambelunghe@unipg.it
[Ti] Título:GC-MS and GC-MS/MS in PCI mode determination of mescaline in peyote tea and in biological matrices.
[So] Source:J Forensic Sci;58(1):270-8, 2013 Jan.
[Is] ISSN:1556-4029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peyote, a cactus containing the hallucinogen mescaline, is used to induce altered states of consciousness in religious ceremonies or for recreational purpose. This study reports a case of an underage boy suspected of mescaline abuse. For this purpose, we analyzed a dark green liquid sample found in the bedroom of the boy whose urine and hair samples were collected shortly after the drink was found. A method by gas chromatography-mass spectrometry tandem mass spectrometry (GC-MS/MS) in positive chemical ionization mode was developed and validated in terms of linearity, specificity, accuracy, and sensitivity for mescaline determination at the low concentrations present in hair. GC-MS analysis of the liquid identified mescaline, while urine was negative; GC-MS/MS segmental hair analysis identified mescaline in the proximal segment (root to 2 cm), while the distal segments were negative. Although peyote was uncommonly encountered, its use was confirmed by segmental hair analysis that can provide long-term information about drugs use.
[Mh] Termos MeSH primário: Cabelo/química
Alucinógenos/análise
Mescalina/análise
Detecção do Abuso de Substâncias/métodos
Chá/química
[Mh] Termos MeSH secundário: Adolescente
Toxicologia Forense
Cromatografia Gasosa-Espectrometria de Massas
Alucinógenos/efeitos adversos
Seres Humanos
Masculino
Mescalina/efeitos adversos
Transtornos Relacionados ao Uso de Substâncias/diagnóstico
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hallucinogens); 0 (Tea); RHO99102VC (Mescaline)
[Em] Mês de entrada:1308
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120821
[St] Status:MEDLINE
[do] DOI:10.1111/j.1556-4029.2012.02249.x



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