Base de dados : MEDLINE
Pesquisa : D02.092.570 [Categoria DeCS]
Referências encontradas : 3509 [refinar]
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  1 / 3509 MEDLINE  
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[PMID]:28703366
[Au] Autor:Ma W; Zhu M; Yang L; Yang T; Zhang Y
[Ad] Endereço:School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, Shaanxi, China.
[Ti] Título:Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling.
[So] Source:Phytother Res;31(9):1392-1399, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:TPD7, a novel biphenyl urea taspine derivative, and berberine have presented inhibition on VEGFR2 that can be regulated by ephrin-B2 reverse signaling through interactions with the PDZ domain. The purpose of this study is to investigate the inhibitory effect of the combination of TPD7 and berberine (TAB) on T-cell acute lymphoblastic leukemia cell growth. TPD7 and berberine together synergistically inhibited the proliferation of Jurkat cells. Also, the combination of TAB induced G -phase cell-cycle arrest by downregulating the level of cyclin D1, cyclin E, and CDC2. Furthermore, the combination of TAB significantly enhanced apoptosis in Jurkat cells, and the apoptosis most likely resulted from the modulation of the level of Bcl-2 family members. Most importantly, the concomitant treatment simultaneously regulated the ephrin-B2 and VEGFR2 signaling, as well as modulated the MEK/ERK and PTEN/PI3K/AKT/mTOR signaling. Therefore, the combination treatment of TAB may be a promising therapeutic method in treating T-cell acute lymphoblastic leukemia. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Berberina/farmacologia
Carbanilidas/farmacologia
Efrina-B2/metabolismo
Hidroxilaminas/farmacologia
Leucemia-Linfoma Linfoblástico de Células T Precursoras/patologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sinergismo Farmacológico
Seres Humanos
Células Jurkat
Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbanilides); 0 (Ephrin-B2); 0 (Hydroxylamines); 0 (TPD7 compound); 0I8Y3P32UF (Berberine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5866


  2 / 3509 MEDLINE  
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[PMID]:28668345
[Au] Autor:Janaki Ramaiah M; Naushad SM; Lavanya A; Srinivas C; Anjana Devi T; Sampathkumar S; Dharan DB; Bhadra MP
[Ad] Endereço:School of Chemical and Biotechnology, SASTRA University, Thanjavur 613401, India. Electronic address: janakiramaiah@scbt.sastra.edu.
[Ti] Título:Scriptaid cause histone deacetylase inhibition and cell cycle arrest in HeLa cancer cells: A study on structural and functional aspects.
[So] Source:Gene;627:379-386, 2017 Sep 05.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Scriptaid (SCR), a well-known histone deacetylase inhibitor, cause various cellular effects such as cell growth inhibition and apoptosis. In this study, we have evaluated the anti-cancer effects of Scriptaid in HeLa cells, IMR-32 and HepG2 cells. Scriptaid inhibited the growth of HeLa cells with IC of 2µM at 48h in a dose-dependent manner. Flow-cytometric analysis indicated that SCR induced apoptosis. Scriptaid was found to inhibit HDAC-8 effectively than other HDAC inhibitor such as TSA as observed by HDAC-8 assay, Western blotting and modelling study. This observation was further strengthened by an artificial neuronal network (ANN) model.
[Mh] Termos MeSH primário: Pontos de Checagem do Ciclo Celular
Inibidores de Histona Desacetilases/farmacologia
Hidroxilaminas/farmacologia
Quinolinas/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Sítios de Ligação
Células HeLa
Histona Desacetilases/química
Histona Desacetilases/metabolismo
Seres Humanos
Simulação de Acoplamento Molecular
Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histone Deacetylase Inhibitors); 0 (Hydroxylamines); 0 (Quinolines); 0 (scriptaid); EC 3.5.1.98 (Histone Deacetylases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


  3 / 3509 MEDLINE  
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[PMID]:28662960
[Au] Autor:Murar CE; Harmand TJ; Bode JW
[Ad] Endereço:Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH-Zürich, CH-8093 Zürich, Switzerland.
[Ti] Título:Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the α-ketoacid-hydroxylamine (KAHA) ligation.
[So] Source:Bioorg Med Chem;25(18):4996-5001, 2017 Sep 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We describe a new route for the synthesis of (S)-N-Boc-5-oxaproline. This building block is a key element for the chemical synthesis of proteins with the α-ketoacid-hydroxylamine (KAHA) ligation. The new synthetic pathway to the enantiopure oxaproline is based on a chiral amine mediated enantioselective conjugate addition of a hydroxylamine to trans-4-oxo-2-butenoate. This route is practical, scalable and economical and provides decagram amounts of material for protein synthesis and conversion to other protected forms of (S)-oxaproline.
[Mh] Termos MeSH primário: Hidroxilaminas/química
Prolina/análogos & derivados
Proteínas/síntese química
[Mh] Termos MeSH secundário: Aldeídos/química
Espectroscopia de Ressonância Magnética
Prolina/síntese química
Prolina/química
Proteínas/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 0 (Hydroxylamines); 0 (Proteins); 0 (alpha-ketoacid-hydroxylamine); 36839-09-5 (5-oxaproline); 9DLQ4CIU6V (Proline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE


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[PMID]:28438312
[Au] Autor:Chen L; Peng Y; Tang M; Wu F
[Ad] Endereço:Department of Chemical and Environmental Engineering, University of California, Riverside, Riverside, CA 92521, USA; School of Resources and Environmental Science, Wuhan University, Wuhan, 430079, PR China.
[Ti] Título:Comment on "Combination of cupric ion with hydroxylamine and hydrogen peroxide for the control of bacterial biofilms on RO membranes by Hye-Jin Lee, Hyung-Eun Kim, Changha Lee [Water Research 110, 2017, 83-90]".
[So] Source:Water Res;118:289-290, 2017 Jul 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The methodology employed by Lee et al. to terminate their bactericidal assays was found to be flawed via our demonstrations. Briefly, EDTA or sulfite combining with cupric ion did not fully terminate, and instead even boosted the P. aeruginosa death. We therefore suggested them to seek for other means of reaction termination, such as the combination of buffering agent PBS and Cu(II)-complexing agent EDTA.
[Mh] Termos MeSH primário: Biofilmes
Peróxido de Hidrogênio
Hidroxilamina
[Mh] Termos MeSH secundário: Hidroxilaminas
Pseudomonas aeruginosa
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydroxylamines); 2FP81O2L9Z (Hydroxylamine); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


  5 / 3509 MEDLINE  
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[PMID]:28412361
[Au] Autor:Wu Y; Xu T; Liu J; Ding K; Xu J
[Ad] Endereço:Institute of Medicinal Chemistry and Biology, College of Pharmacy, Jinan University, Guangzhou, China.
[Ti] Título:Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943.
[So] Source:Biochem Biophys Res Commun;487(2):339-343, 2017 May 27.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IDO1 (indoleamine 2, 3-dioxygenase 1), a well characterized immunosuppressive enzyme, has attracted growing attention as a potential target for cancer immunotherapy. Hydroxylamidine compounds INCB024360 and INCB14943 (INCB024360 analogue) are highly effective IDO1 inhibitors. INCB024360 is undergoing clinical trials for treatment of various types of human cancer. Here, we determined the co-crystal structure of IDO1 and INCB14943, and elucidate the detailed binding mode. INCB14943 binds to heme iron in IDO1 protein through the oxime nitrogen. Further analysis also reveals that a halogen bonding interaction between the chlorine atom (3-Cl) of INCB14943 and the sulphur atom of C129 significantly improves the inhibition activity against IDO1. Comparing with the other reported inhibitors, the oxime nitrogen and halogen bond interaction are identified as the unique features of INCB14943 among the IDO1 inhibitors. Thus, our study provides novel insights into the interaction between a small molecule inhibitor INCB14943 and IDO1 protein. The structural information will facilitate future IDO1 inhibitor design.
[Mh] Termos MeSH primário: Hidroxilaminas/química
Indolamina-Pirrol 2,3,-Dioxigenase/química
Indolamina-Pirrol 2,3,-Dioxigenase/ultraestrutura
Oxidiazóis/química
Oximas/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Ativação Enzimática
Ligação Proteica
Conformação Proteica
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydroxylamines); 0 (INCB14943); 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase); 0 (Oxadiazoles); 0 (Oximes); 0 (indoleamine 2,3-dioxygenase 1, human)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


  6 / 3509 MEDLINE  
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[PMID]:28358480
[Au] Autor:Hou X; Huang X; Jia F; Ai Z; Zhao J; Zhang L
[Ad] Endereço:Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
[Ti] Título:Hydroxylamine Promoted Goethite Surface Fenton Degradation of Organic Pollutants.
[So] Source:Environ Sci Technol;51(9):5118-5126, 2017 May 02.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, we construct a surface Fenton system with hydroxylamine (NH OH), goethite (α-FeOOH), and H O (α-FeOOH-HA/H O ) to degrade various organic pollutants including dyes (methyl orange, methylene blue, and rhodamine B), pesticides (pentachlorophenol, alachlor, and atrazine), and antibiotics (tetracycline, chloramphenicol, and lincomycin) at pH 5.0. In this surface Fenton system, the presence of NH OH could greatly promote the H O decomposition on the α-FeOOH surface to produce ·OH without releasing any detectable iron ions during the alachlor degradation, which was different from some previously reported heterogeneous Fenton counterparts. Moreover, the ·OH generation rate constant of this surface Fenton system was 10 -10 times those of previous heterogeneous Fenton processes. The interaction between α-FeOOH and NH OH was investigated with using attenuated total reflectance Fourier transform infrared spectroscopy and density functional theory calculations. The effective degradation of organic pollutants in this surface Fenton system was ascribed to the efficient Fe(III)/Fe(II) cycle on the α-FeOOH surface promoted by NH OH, which was confirmed by X-ray photoelectron spectroscopy analysis. The degradation intermediates and mineralization of alachlor in this surface Fenton system were then systematically investigated using total organic carbon and ion chromatography, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry. This study offers a new strategy to degrade organic pollutants and also sheds light on the environmental effects of goethite.
[Mh] Termos MeSH primário: Compostos Férricos/química
Peróxido de Hidrogênio/química
[Mh] Termos MeSH secundário: Hidroxilamina
Hidroxilaminas
Ferro/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Hydroxylamines); 2FP81O2L9Z (Hydroxylamine); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.6b05906


  7 / 3509 MEDLINE  
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[PMID]:28341057
[Au] Autor:Kim YH; Lee JK
[Ad] Endereço:Department of Biology Education, College of Education, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
[Ti] Título:Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression.
[So] Source:Cell Immunol;316:11-20, 2017 Jun.
[Is] ISSN:1090-2163
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The modulation of immature dendritic cells (iDCs), which involves processes such as phagocytosis, migration, and maturation, is considered a beneficial research theme. Once activated by an antigen, iDCs turn to mature DCs (mDCs) and migrate towards secondary lymphoid organs, and initiate the progress of cellular immunity. Histone deacetylase inhibitors (HDACis) are also thought to be a major modulator of cellular immunity. Herein, we demonstrate that HDACis (trichostatin-A (TSA), sodium butylate (SB), scriptaid (ST)) play a central regulatory role in the migratory activity of iDCs. In our results, TSA, SB and ST showed the potent inhibitory effect on the migration of iDCs stimulated by MIP-1α. The inhibitory activities of HDACis were found to be caused by reduction of CCR1 expression on the cell surface, and by the inhibition of phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and c-Jun N-terminal kinase (JNK).
[Mh] Termos MeSH primário: Movimento Celular/efeitos dos fármacos
Células Dendríticas
Inibidores de Histona Desacetilases/farmacologia
[Mh] Termos MeSH secundário: Animais
Ácido Butírico/farmacologia
Diferenciação Celular/efeitos dos fármacos
Células Cultivadas
Quimiocina CCL3/farmacologia
Células Dendríticas/citologia
Células Dendríticas/efeitos dos fármacos
Células Dendríticas/imunologia
Regulação para Baixo
Ácidos Hidroxâmicos/farmacologia
Hidroxilaminas/farmacologia
Camundongos
Camundongos Endogâmicos C57BL
Quinolinas/farmacologia
Receptores CCR1/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ccl3 protein, mouse); 0 (Chemokine CCL3); 0 (Histone Deacetylase Inhibitors); 0 (Hydroxamic Acids); 0 (Hydroxylamines); 0 (Quinolines); 0 (Receptors, CCR1); 0 (scriptaid); 107-92-6 (Butyric Acid); 3X2S926L3Z (trichostatin A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE


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[PMID]:28284823
[Au] Autor:Deyama S; Sugano Y; Mori S; Amano T; Yoshioka M; Kaneda K; Minami M
[Ad] Endereço:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan; Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
[Ti] Título:Activation of the NMDA receptor-neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain.
[So] Source:Neuropharmacology;118:59-68, 2017 May 15.
[Is] ISSN:1873-7064
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pain consists of sensory and affective components. Although the neuronal mechanisms underlying the sensory component of pain have been studied extensively, those underlying its affective component are only beginning to be elucidated. Previously, we showed the pivotal role of the ventral part of the bed nucleus of the stria terminalis (vBNST) in the negative affective component of pain. Here, we examined the role of glutamate-nitric oxide (NO) signaling in the affective component of pain in rats using a conditioned place aversion (CPA) test. Intra-vBNST injection of either CNQX (an AMPA receptor antagonist) or MK-801 (an NMDA receptor antagonist) dose-dependently attenuated intraplantar formalin-induced CPA (F-CPA) without reducing nociceptive behaviors. In vivo microdialysis showed that extracellular oxidative NO metabolites (NOx) levels were significantly increased by intraplantar formalin injection. Intra-vBNST injection of NPLA (a selective neuronal NO synthase (nNOS) inhibitor), c-PTIO (a NO scavenger), or ZL006 (a postsynaptic density-95 (PSD-95)-nNOS interaction inhibitor) dose-dependently suppressed F-CPA without attenuating nociceptive behaviors. Intra-vBNST injection of NOR3 (a NO donor) produced CPA in a dose-dependent manner in the absence of noxious stimulation. Furthermore, whole-cell patch-clamp electrophysiology in the vBNST slices revealed that NOR3 induced depolarization of hyperpolarization-activated cation current (I )-positive vBNST neurons, which was blocked by the NO scavenger. These results suggest that activation of glutamatergic transmission and subsequent nNOS-derived NO production within the vBNST mediate the negative affective component of pain and that NO-evoked excitation of I -positive vBNST neurons may be among the cellular mechanisms underlying pain-induced aversion.
[Mh] Termos MeSH primário: Óxido Nítrico Sintase Tipo I/metabolismo
Manejo da Dor
Dor/fisiopatologia
Receptores de N-Metil-D-Aspartato/metabolismo
Núcleos Septais/metabolismo
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Animais
Condicionamento Operante/efeitos dos fármacos
Óxidos N-Cíclicos/farmacologia
Modelos Animais de Doenças
Potenciais Pós-Sinápticos Excitadores/efeitos dos fármacos
Formaldeído/toxicidade
Depuradores de Radicais Livres/farmacologia
Hidroxilaminas/farmacologia
Imidazóis/farmacologia
Masculino
Potenciais da Membrana/efeitos dos fármacos
Neurônios/efeitos dos fármacos
Dor/induzido quimicamente
Medição da Dor/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Núcleos Septais/citologia
Núcleos Septais/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclic N-Oxides); 0 (Free Radical Scavengers); 0 (Hydroxylamines); 0 (Imidazoles); 0 (Receptors, N-Methyl-D-Aspartate); 0 (ethyl-2-(hydroxyamino)-5-nitro-3-hexenamide); 18390-00-6 (2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide); 1HG84L3525 (Formaldehyde); EC 1.14.13.39 (Nitric Oxide Synthase Type I)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  9 / 3509 MEDLINE  
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[PMID]:28264518
[Au] Autor:Al-Wabli RI; Al-Ghamdi AR; Ghabbour HA; Al-Agamy MH; Monicka JC; Joe IH; Attia MI
[Ad] Endereço:Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ralwabli@KSU.EDU.SA.
[Ti] Título:Synthesis, X-ray Single Crystal Structure, Molecular Docking and DFT Computations on N-[(1E)-1-(2H-1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]-hydroxylamine: A New Potential Antifungal Agent Precursor.
[So] Source:Molecules;22(3), 2017 Feb 28.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mycoses are serious health problem, especially in immunocompromised individuals. A new imidazole-bearing compound containing an oxime functionality was synthesized and characterized with different spectroscopic techniques to be used for the preparation of new antifungal agents. The stereochemistry of the oxime double bond was unequivocally determined via the single crystal X-ray technique. The title compound , C H N3O3·C3H8O, crystallizes in the monoclinic space group 21with = 9.0963(3) Å, = 14.7244(6) Å, = 10.7035(4) Å, ß = 94.298 (3)°, = 1429.57(9) ų, = 2. The molecules were packed in the crystal structure by eight intermolecular hydrogen bond interactions. A comprehensive spectral analysis of the title molecule has been performed based on the scaled quantum mechanical (SQM) force field obtained by density-functional theory (DFT) calculations. A molecular docking study illustrated the binding mode of the title compound into its target protein. The preliminary antifungal activity of the title compound was determined using a broth microdilution assay.
[Mh] Termos MeSH primário: Antifúngicos/síntese química
Hidroxilaminas/síntese química
Imidazóis/síntese química
[Mh] Termos MeSH secundário: Antifúngicos/química
Antifúngicos/farmacologia
Cristalografia por Raios X
Ligações de Hidrogênio
Hidroxilaminas/química
Hidroxilaminas/farmacologia
Imidazóis/química
Imidazóis/farmacologia
Modelos Moleculares
Simulação de Acoplamento Molecular
Teoria Quântica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Hydroxylamines); 0 (Imidazoles); 7GBN705NH1 (imidazole)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


  10 / 3509 MEDLINE  
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[PMID]:28164698
[Au] Autor:Terada A; Sugawara S; Hojo K; Takeuchi Y; Riya S; Harper WF; Yamamoto T; Kuroiwa M; Isobe K; Katsuyama C; Suwa Y; Koba K; Hosomi M
[Ad] Endereço:Department of Chemical Engineering, Tokyo University of Agriculture and Technology , 2-24-16 Naka, Koganei, Tokyo 184-8588 Japan.
[Ti] Título:Hybrid Nitrous Oxide Production from a Partial Nitrifying Bioreactor: Hydroxylamine Interactions with Nitrite.
[So] Source:Environ Sci Technol;51(5):2748-2756, 2017 Mar 07.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The goal of this study was to elucidate the mechanisms of nitrous oxide (N O) production from a bioreactor for partial nitrification (PN). Ammonia-oxidizing bacteria (AOB) enriched from a sequencing batch reactor (SBR) were subjected to N O production pathway tests. The N O pathway test was initiated by supplying an inorganic medium to ensure an initial NH -N concentration of 160 mg-N/L, followed by NO (20 mg-N/L) and dual NH OH (each 17 mg-N/L) spikings to quantify isotopologs of gaseous N O ( N O, N O, and N O). N O production was boosted by NH OH spiking, causing exponential increases in mRNA transcription levels of AOB functional genes encoding hydroxylamine oxidoreductase (haoA), nitrite reductase (nirK), and nitric oxide reductase (norB) genes. Predominant production of N O among N O isotopologs (46% of total produced N O) indicated that coupling of NH OH with NO produced N O via N-nitrosation hybrid reaction as a predominant pathway. Abiotic hybrid N O production was also observed in the absence of the AOB-enriched biomass, indicating multiple pathways for N O production in a PN bioreactor. The additional N O pathway test, where NH was spiked into 400 mg-N/L of NO concentration, confirmed that the hybrid N O production was a dominant pathway, accounting for approximately 51% of the total N O production.
[Mh] Termos MeSH primário: Nitritos/metabolismo
Óxido Nitroso/metabolismo
[Mh] Termos MeSH secundário: Amônia/metabolismo
Reatores Biológicos/microbiologia
Hidroxilamina
Hidroxilaminas
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydroxylamines); 0 (Nitrites); 2FP81O2L9Z (Hydroxylamine); 7664-41-7 (Ammonia); K50XQU1029 (Nitrous Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.6b05521



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