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  1 / 2916 MEDLINE  
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[PMID]:28050751
[Au] Autor:Lauridsen TK; Iversen KK; Ihlemann N; Hasbak P; Loft A; Berthelsen AK; Dahl A; Dejanovic D; Albrecht-Beste E; Mortensen J; Kjær A; Bundgaard H; Bruun NE
[Ad] Endereço:Department of Cardiology, The Heart Center, Copenhagen University Hospital, Copenhagen, Denmark. trineklauridsen@gmail.com.
[Ti] Título:Clinical utility of F-FDG positron emission tomography/computed tomography scan vs. Tc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis.
[So] Source:Int J Cardiovasc Imaging;33(5):751-760, 2017 May.
[Is] ISSN:1875-8312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE. A team of 2 × 2 cardiologists evaluated each finding to determine clinical relevance. Clinical utility was determined by 4 criteria converted into an ordinal scale. Using the manifestation with highest clinical utility rating in each patient, the clinical impact of the two imaging modalities was expressed in a clinical utility score. To evaluate reproducibility for each modality, an imaging core laboratory reviewed all findings. In 55 IE patients, 91 pathological foci were found by FDG-PET/CT and 37 foci were identified by WBC-SPECT/CT (p < 0.001). The clinical utility of FDG-PET/CT was significantly higher than that of WBC-SPECT/CT when comparing clinical utility score (2.06 vs. 1.17; p = 0.01). In assessment of extra-cardiac diagnostics in IE, inter-observer reproducibility was substantial for WBC-SPECT/CT (k 0.69, 95% CI 0.49-0.89) and substantial to excellent for FDG-PET/CT (k 0.79, 95% CI 0.61-0.98). FDG-PET/CT has a significantly higher clinical utility score than WBC SPECT/CT and is potentially superior to WBC-SPECT/CT in detection of extra-cardiac pathology in patients with IE.
[Mh] Termos MeSH primário: Endocardite/diagnóstico por imagem
Fluordesoxiglucose F18/administração & dosagem
Leucócitos
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos/administração & dosagem
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único
Tecnécio Tc 99m Exametazima/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Endocardite/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Variações Dependentes do Observador
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1007/s10554-016-1047-1


  2 / 2916 MEDLINE  
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[PMID]:27853826
[Au] Autor:Coelho PB; Fernandes A; Oliveira A; Faria T; Pereira J
[Ad] Endereço:Universidade Fernando Pessoa Faculdade de Ciencias da Saude, Porto, Portugal. pbarata@ufp.edu.pt.
[Ti] Título:Brain perfusion SPECT for brain death assessment.
[So] Source:Eur J Nucl Med Mol Imaging;44(2):350-351, 2017 Feb.
[Is] ISSN:1619-7089
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Morte Encefálica/diagnóstico por imagem
Encéfalo/diagnóstico por imagem
Angiografia Cerebral/métodos
Imagem de Perfusão/métodos
Tecnécio Tc 99m Exametazima
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Evolução Fatal
Seres Humanos
Masculino
Meia-Idade
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.1007/s00259-016-3565-4


  3 / 2916 MEDLINE  
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[PMID]:27900758
[Au] Autor:Derlin T; Weiberg D
[Ad] Endereço:Hannover Medical School. Derlin.Thorsten@mh-hannover.de.
[Ti] Título:99mTc-HMPAO perfusion SPECT/CT in the diagnosis of brain death.
[So] Source:Nucl Med Rev Cent East Eur;19(B):22-23, 2016.
[Is] ISSN:1644-4345
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain. SPECT/CT confirmed absence of tracer accumulation, and was deemed helpful for evaluation of the brain stem. 99mTc-HMPAO SPECT/CT is a valuable tool enabling imaging-based confirmation of BD.
[Mh] Termos MeSH primário: Morte Encefálica/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Encéfalo/irrigação sanguínea
Encéfalo/diagnóstico por imagem
Tronco Encefálico/irrigação sanguínea
Tronco Encefálico/diagnóstico por imagem
Circulação Cerebrovascular
Neuroimagem Funcional
Seres Humanos
Masculino
Compostos Radiofarmacêuticos
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único
Tecnécio Tc 99m Exametazima
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.5603/NMR.2016.0033


  4 / 2916 MEDLINE  
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[PMID]:27764040
[Au] Autor:Matesan MC; Elojeimy S; Minoshima S
[Ad] Endereço:From the *Department of Radiology, University of Washington, Seattle, WA; †Department of Radiology, University of New Mexico, Albuquerque, NM; and ‡Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT.
[Ti] Título:123I-FP-CIT and 99mTc-HMPAO in Pathologically Confirmed Progressive Supranuclear Palsy.
[So] Source:Clin Nucl Med;41(12):e514-e516, 2016 Dec.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted by quantitative analyses but unremarkable MRI 16 months after the onset of symptoms. Brain autopsy demonstrated presence of neuronal and glial tau pathology in both cortical and subcortical regions confirming the diagnosis of progressive supranuclear palsy. This case illustrates potential values of multimodal molecular brain imaging in conjunction with quantitative analysis in the evaluation of movement disorders.
[Mh] Termos MeSH primário: Compostos Radiofarmacêuticos
Paralisia Supranuclear Progressiva/diagnóstico por imagem
Tecnécio Tc 99m Exametazima
Tropanos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Tomografia Computadorizada de Emissão de Fóton Único
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0 (Tropanes); 155797-99-2 (2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  5 / 2916 MEDLINE  
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[PMID]:27565302
[Au] Autor:Colloby SJ; Field RH; Wyper DJ; O'Brien JT; Taylor JP
[Ad] Endereço:Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK. Electronic address: sean.colloby@ncl.ac.uk.
[Ti] Título:A spatial covariance I-5IA-85380 SPECT study of α4ß2 nicotinic receptors in Alzheimer's disease.
[So] Source:Neurobiol Aging;47:83-90, 2016 Nov.
[Is] ISSN:1558-1497
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these deficits and relationship with known brain networks is unknown. In this study, we sought to clarify this and used I-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine ( 5IA-85380) single photon emission computed tomography to investigate spatial covariance of α4ß2 nicotinic acetylcholine receptors in AD and healthy controls. Thirteen AD and 16 controls underwent 5IA-85380 and regional cerebral blood flow ( Tc-exametazime) single photon emission computed tomography scanning. We applied voxel principal component (PC) analysis, generating series of principal component images representing common intercorrelated voxels across subjects. Linear regression generated specific α4ß2 and regional cerebral blood flow covariance patterns that differentiated AD from controls. The α4ß2 pattern showed relative decreased uptake in numerous brain regions implicating several networks including default mode, salience, and Papez hubs. Thus, as well as basal forebrain and brainstem cholinergic system dysfunction, cholinergic deficits mediated through nicotinic acetylcholine receptors could be evident within key networks in AD. These findings may be important for the pathophysiology of AD and its associated cognitive and behavioral phenotypes.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico por imagem
Doença de Alzheimer/metabolismo
Azetidinas
Prosencéfalo/diagnóstico por imagem
Prosencéfalo/metabolismo
Piridinas
Compostos Radiofarmacêuticos
Receptores Nicotínicos/metabolismo
Tomografia Computadorizada de Emissão de Fóton Único
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/etiologia
Circulação Cerebrovascular
Feminino
Seres Humanos
Masculino
Tecnécio Tc 99m Exametazima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5-iodo-3-(2-azetidinylmethoxy)pyridine); 0 (Azetidines); 0 (Pyridines); 0 (Radiopharmaceuticals); 0 (Receptors, Nicotinic); 0 (nicotinic receptor alpha4beta2); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE


  6 / 2916 MEDLINE  
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[PMID]:27246971
[Au] Autor:Espinosa P; Spriet M; Sole A; Walker NJ; Vaughan B; Galuppo LD
[Ad] Endereço:Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, California.
[Ti] Título:Scintigraphic Tracking of Allogeneic Mesenchymal Stem Cells in the Distal Limb After Intra-Arterial Injection in Standing Horses.
[So] Source:Vet Surg;45(5):619-24, 2016 Jul.
[Is] ISSN:1532-950X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the feasibility of intra-arterial administration of allogeneic mesenchymal stem cells (MSC) in the median artery of standing horses and evaluate the distribution and retention of radiolabeled cells. STUDY DESIGN: In vivo experimental study. ANIMALS: Six research horses. METHODS: Technetium(99m) -HexaMethyl-Propylene-Amine Oxime-labeled MSC were injected under ultrasound guidance in the median artery of 6 front limbs of 3 horses, standing under sedation. Scintigraphic images were obtained at the time of injection, and at 1, 6, and 24 hours postinjection. Six additional limbs from 3 horses were similarly injected with unlabeled MSC. Ultrasound was performed the following day for assessment of vascular changes. RESULTS: Intra-arterial injection was performed successfully in 11 of 12 limbs. In 1 limb, partial periarterial injection compromised the success of the procedure. Homogeneous distribution of radiolabeled MSC was observed through the entire distal limb, including within the hoof. Partial venous thrombosis was found in both groups of horses, but was subjectively less severe in horses injected with unlabeled MSC. No lameness was observed. Transient swelling of the distal limb occurred in only 1 limb. CONCLUSION: Intra-arterial injection of MSC can be performed in standing horses under sedation and successfully distribute MSC to the distal limb. A risk of periarterial injection was identified but can be reduced with proper sedation, local anesthesia, and increased experience. Partial venous thrombosis was observed as a complication, but did not cause changes of clinical importance, other than rare transient swelling.
[Mh] Termos MeSH primário: Artérias/diagnóstico por imagem
Cavalos
Transplante de Células-Tronco Mesenquimais/veterinária
Compostos Radiofarmacêuticos/farmacocinética
Tecnécio Tc 99m Exametazima/farmacocinética
[Mh] Termos MeSH secundário: Animais
Membro Posterior/irrigação sanguínea
Membro Posterior/diagnóstico por imagem
Injeções Intra-Arteriais/veterinária
Cintilografia/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE
[do] DOI:10.1111/vsu.12485


  7 / 2916 MEDLINE  
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[PMID]:27179747
[Au] Autor:Lezaic L; Socan A; Peitl PK; Poglajen G; Sever M; Cukjati M; Cernelc P; Vrtovec B
[Ad] Endereço:Department for Nuclear Medicine, UMC Ljubljana, Slovenia. Electronic address: luka.lezaic@kclj.si.
[Ti] Título:Imaging and 1-day kinetics of intracoronary stem cell transplantation in patients with idiopathic dilated cardiomyopathy.
[So] Source:Nucl Med Biol;43(7):410-4, 2016 Jul.
[Is] ISSN:1872-9614
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stem cell transplantation is an emerging method of treatment for patients with cardiovascular disease. There are few studies completed or ongoing on stem cell therapy in patients with idiopathic dilated cardiomyopathy (IDCM). Information on stem cell homing and distribution in the myocardium after transplantation might provide important insight into effectiveness of transplantation procedure. AIM: To assess early engraftment, retention and migration of intracoronarily transplanted stem cells in the myocardium of patients with advanced dilated cardiomyopathy of non-ischaemic origin using stem cell labeling with (99m)Tc-exametazime (HMPAO). MATERIALS, METHODS: Thirty-five patients with IDCM and advanced heart failure were included in the study. Autologous hematopoietic (CD34+) stem cells were harvested by peripheral blood apheresis after bone marrow stimulation, labeled with (99m)Tc-HMPAO, tested for viability and injected into coronary vessel supplying areas of myocardium selected by myocardial perfusion scintigraphy as dysfunctional yet viable. Imaging was performed 1h and 18h after transplantation. RESULTS: Myocardial stem cell retention ranged from 0 to 1.44% on early and 0-0.97% on delayed imaging. Significant efflux of stem cells occurred from site of delivery in this time period (p<0.001). Stem cell viability was not affected by labeling. CONCLUSION: Stem cell labeling with (99m)Tc-HMPAO is a feasible method for stem cell tracking after transplantation in patients with IDCM.
[Mh] Termos MeSH primário: Cardiomiopatia Dilatada/diagnóstico por imagem
Cardiomiopatia Dilatada/cirurgia
Vasos Coronários/cirurgia
Transplante de Células-Tronco
[Mh] Termos MeSH secundário: Adulto
Movimento Celular
Sobrevivência Celular
Feminino
Seres Humanos
Cinética
Masculino
Células-Tronco/citologia
Células-Tronco/metabolismo
Tecnécio Tc 99m Exametazima/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160516
[St] Status:MEDLINE


  8 / 2916 MEDLINE  
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[PMID]:27117205
[Au] Autor:Maucksch U; Runge R; Wunderlich G; Freudenberg R; Naumann A; Kotzerke J
[Ad] Endereço:a University Hospital/Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden , Department of Nuclear Medicine , Dresden , Germany.
[Ti] Título:Comparison of the radiotoxicity of the Tc-labeled compounds Tc-pertechnetate, Tc-HMPAO and Tc-MIBI.
[So] Source:Int J Radiat Biol;92(11):698-706, 2016 Nov.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In addition to gamma radiation, Tc emits low-energy Auger electrons with path-lengths of nanometers to micrometers that cannot be utilized for diagnostic procedures; however, they have frequently been discussed for therapeutic applications. We compared radiotoxicity of three Tc-labeled radiopharmaceuticals with differences in the subcellular distribution. MATERIALS AND METHODS: The intracellular radionuclide uptake and subcellular distribution of [ Tc]-pertechnetate ( Tc-pertechnetate), [ Tc]Tc-hexamethyl-propylene-aminoxime ( Tc-HMPAO) and [ Tc]Tc-hexakis-2-methoxyisobutylisonitrile ( Tc-MIBI) were quantified in rat thyroid FRTL-5 cells. Radiotoxicity was compared using late phosphorylated histone H2AX (γH2AX) foci as a marker for unrepaired DNA double-strand breaks (DNA-DSB) and clonogenic cell survival. RESULTS: Tc-HMPAO showed a substantially higher uptake into the nucleus and the membrane/organelles than Tc-pertechnetate or Tc-MIBI. The colony-forming assay showed that Tc-pertechnetate and Tc-HMPAO caused a similar reduction in cell survival. Tc-MIBI is less radiotoxic in terms of the estimated nucleus dose and induced the fewest number of γH2AX foci compared with the other Tc-tracers, and Tc-HMPAO induced a fewer number of γH2AX foci than Tc-pertechnetate. CONCLUSIONS: Our findings reveal that clonogenic cellular survival is not solely determined by the DNA-DSB response. This finding may suggest the involvement of extra-nuclear radiosensitive targets in cell inactivation. For example, the mitochondria or the cell membrane could be affected by Tc-HMPAO.
[Mh] Termos MeSH primário: Compostos de Tecnécio/farmacocinética
Compostos de Tecnécio/uso terapêutico
Neoplasias da Glândula Tireoide/metabolismo
Neoplasias da Glândula Tireoide/radioterapia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos da radiação
Relação Dose-Resposta à Radiação
Marcação por Isótopo
Compostos Radiofarmacêuticos/farmacocinética
Compostos Radiofarmacêuticos/uso terapêutico
Dosagem Radioterapêutica
Ratos
Pertecnetato Tc 99m de Sódio/farmacocinética
Pertecnetato Tc 99m de Sódio/uso terapêutico
Tecnécio Tc 99m Exametazima/farmacocinética
Tecnécio Tc 99m Exametazima/uso terapêutico
Tecnécio Tc 99m Sestamibi/farmacocinética
Tecnécio Tc 99m Sestamibi/uso terapêutico
Neoplasias da Glândula Tireoide/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0 (Technetium Compounds); 3B744AG22N (Technetium Tc 99m Exametazime); 971Z4W1S09 (Technetium Tc 99m Sestamibi); A0730CX801 (Sodium Pertechnetate Tc 99m)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE


  9 / 2916 MEDLINE  
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[PMID]:27111811
[Au] Autor:Doruyter A; Lochner C; Jordaan GP; Stein DJ; Dupont P; Warwick JM
[Ad] Endereço:Division of Nuclear Medicine, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: doruyter@sun.ac.za.
[Ti] Título:Resting functional connectivity in social anxiety disorder and the effect of pharmacotherapy.
[So] Source:Psychiatry Res;251:34-44, 2016 May 30.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Neuroimaging research has reported differences in resting-state functional connectivity (RFC) between social anxiety disorder (SAD) patients and healthy controls (HCs). Limited research has examined the effect of treatment on RFC in SAD. We performed a study to identify differences in RFC between SAD and HC groups, and to investigate the effect of pharmacotherapy on RFC in SAD. Seed-based RFC analysis was performed on technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) SPECT scans using a cross-subject approach in SPM-12. Seeds were chosen to represent regions in a recently published network model of SAD. A second-level regression analysis was performed to further characterize the underlying relationships identified in the group contrasts. Twenty-three SAD participants were included, of which 18 underwent follow-up measures after an 8-week course of citalopram or moclobemide. Fifteen healthy control (HC) scans were included. SAD participants at baseline demonstrated several significant connectivity disturbances consistent with the existing network model as well as one previously unreported finding (increased connectivity between cerebellum and posterior cingulate cortex). After therapy, the SAD group demonstrated significant increases in connectivity with dorsal anterior cingulate cortex which may explain therapy-induced modifications in how SAD sufferers interpret emotions in others and improvements in self-related and emotional processing.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Citalopram/uso terapêutico
Moclobemida/uso terapêutico
Fobia Social/diagnóstico por imagem
Fobia Social/tratamento farmacológico
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Adulto
Antidepressivos/farmacologia
Antidepressivos/uso terapêutico
Encéfalo/efeitos dos fármacos
Encéfalo/fisiologia
Citalopram/farmacologia
Emoções/efeitos dos fármacos
Emoções/fisiologia
Feminino
Giro do Cíngulo/fisiopatologia
Seres Humanos
Masculino
Moclobemida/farmacologia
Neuroimagem/métodos
Fobia Social/psicologia
Descanso/fisiologia
Tecnécio Tc 99m Exametazima
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0DHU5B8D6V (Citalopram); 3B744AG22N (Technetium Tc 99m Exametazime); PJ0Y7AZB63 (Moclobemide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE


  10 / 2916 MEDLINE  
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[PMID]:27017602
[Au] Autor:Kameyama M; Murakami K; Jinzaki M
[Ad] Endereço:Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. kame-tky@umin.ac.jp.
[Ti] Título:Optimal HMPAO α value for Lassen's correction algorithm obscured by statistical noise.
[So] Source:Ann Nucl Med;30(6):445-9, 2016 Jul.
[Is] ISSN:1864-6433
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: [(99m)Tc] D,L-hexamethyl-propyeneamine oxime ((99m)Tc-HMPAO), a brain perfusion tracer, suffers significant underestimation of regional cerebral blood flow (rCBF). Lassen et al. developed their linearization algorithm to correct the influence of back-diffusion of the tracer, and proposed their parameter α as 1.5. Based on mathematical modeling and literature review, recently, a new α value of 0.5 has been proposed for Lassen's correction algorithm for (99m)Tc-HMPAO, although correction using the old α value of 1.5 was confirmed to be sufficient. Inugami et al. reported that linearization correction gives a stable correlation coefficient over a wide range of α. Our hypotheses are that statistical noise is the source of the stable correlation coefficient presented by them and that the robustness of the correlation coefficient is the reason why many studies confirmed the value of α as 1.5. METHODS: Statistical noise was added in silico to the count, whose relationship with flow was α = 0.5. Then, the count was corrected by Lassen's linearization algorithm with a variety of α. RESULTS: This study confirmed the hypothesis that smaller α values (strong correction) increase the noise at high flow values, leading to nominal increases in correlation coefficient as α decreases. CONCLUSION: Despite this, adoption of the new, smaller α value of 0.5 would be more useful clinically in regaining the contrast between low-flow and high-flow areas of the brain.
[Mh] Termos MeSH primário: Algoritmos
Processamento de Imagem Assistida por Computador
Razão Sinal-Ruído
Tecnécio Tc 99m Exametazima
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Encéfalo/irrigação sanguínea
Encéfalo/diagnóstico por imagem
Circulação Cerebrovascular
Modelos Teóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160328
[St] Status:MEDLINE
[do] DOI:10.1007/s12149-016-1073-z



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