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[PMID]:29254310
[Au] Autor:Chen CY; Chen J; Xia CC; Huang ZX; Song B
[Ad] Endereço:Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
[Ti] Título:T1 mapping combined with Gd-EOB-DTPA-enhanced magnetic resonance imaging in predicting the pathologic grading of hepatocellular carcinoma.
[So] Source:J Biol Regul Homeost Agents;31(4):1029-1036, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the value of Gd-EOB-DTPA-enhanced MRI on hepatobiliary phase (HBP) imaging and T1 mapping sequence in the differentiation of hepatocellular carcinoma (HCC). A total of 45 patients with HCC who were to undergo a resection were enrolled in this study. Gd-EOB-DTPA-enhanced magnetic resonance examination was performed prior to resection. T1 mapping was performed before and 20 min after injection of Gd-EOB-DTPA. T1 values of the lesions were measured on pre-contrast (T1p) and during HBP (T1-HBP) on T1 maps. The signal intensity, the diameter and the margin of HCC lesions on HBP images were analyzed. The reduction in T1 value (T1d) and the reduction rate (ΔT1%) of T1 mapping between pre-contrast and HBP were calculated. The Edmondson-Steiner classification of each lesion was made after surgery. The SPSS software package was used for statistical analysis and the analysis of receiver operator characteristic (ROC) curve and area under the curve (AUC) were carried out by using MedCalc software package. Mean values of T1p and T1-HBP were 1935.4±730.8 ms and 1257.1±529.1 ms, respectively. T1p accuracy (AUC = 0.685, p = 0.037) in predicting pathological grading was similar to that of T1-HBP (AUC = 0.751, p = 0.005). A T1p of 1648.2 ms or greater had a sensitivity and specificity of 85.19% and 61.11%, respectively. A T1-HBP of 1006 ms or greater had a sensitivity and specificity of 81.84% and 61.11%, respectively. The number of HCCs with a non-smooth tumor margin was 20 (44.4%), and a non-smooth tumor margin correlated moderately with the Edmondson-Steiner grade (Spearman r = 0.491, p = 0.041). There was no significant correlation between T1d, ΔT1%, HCC signal intensity on HBP image and lesion diameter with pathologic grading. T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/diagnóstico por imagem
Meios de Contraste/farmacocinética
Gadolínio DTPA/farmacocinética
Neoplasias Hepáticas/diagnóstico por imagem
Fígado/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Área Sob a Curva
Carcinoma Hepatocelular/patologia
Carcinoma Hepatocelular/cirurgia
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Fígado/patologia
Fígado/cirurgia
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/cirurgia
Masculino
Meia-Idade
Gradação de Tumores
Estudos Prospectivos
Curva ROC
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (gadolinium ethoxybenzyl DTPA); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:28747271
[Au] Autor:Jonczyk M; Chapiro J; Collettini F; Geisel D; Schnapauff D; Streitparth F; Schmidt T; Hamm B; Gebauer B; Wieners G
[Ad] Endereço:Department of Radiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address: martin.jo
[Ti] Título:Diagnostic Accuracy of Split-Bolus Single-Phase Contrast-Enhanced Cone-Beam CT for the Detection of Liver Tumors before Transarterial Chemoembolization.
[So] Source:J Vasc Interv Radiol;28(10):1378-1385, 2017 Oct.
[Is] ISSN:1535-7732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate detectability of hepatocellular carcinoma (HCC) using split-bolus cone-beam CT in intraindividual comparison between cone-beam CT and contrast-enhanced MR imaging. MATERIALS AND METHODS: In a retrospective, single-center study, 28 patients with 85 HCC tumors were treated with transarterial chemoembolization between May 2015 and June 2016. All patients underwent arterial and hepatobiliary phase (HBP) MR imaging within 1 month before transarterial chemoembolization. Cone-beam CT images were acquired using a split-bolus contrast injection with 2 contrast injections and 1 cone-beam CT acquisition. Statistical analyses included Friedman 2-way analysis, Kendall coefficient of concordance, and Wilcoxon test. Tumor detectability was scored using a 5-point system (1 = best; 5 = worst) by 2 independent readers resulting in 170 evaluated tumors. Quantitative analysis included signal-to-noise and contrast-to-noise ratio and contrast measurements. P values < .05 were considered significant. RESULTS: Better tumor detection was provided with split-bolus cone-beam CT (2.91/2.73) and HBP MR imaging (2.93/2.21) compared with arterial MR imaging (3.72/3.05; P < .001) without statistical difference between cone-beam CT and HBP MR imaging in terms of detectability (P = .154) and sensitivity for hypervascularized tumors. More tumors were identified on cone-beam CT (n = 121/170) than on arterial MR imaging (n = 94/170). Average contrast-to-noise ratio values of arterial and HBP MR imaging were higher than for cone-beam CT (7.79, 8.58, 4.43), whereas contrast values were higher for cone-beam CT than for MR imaging (0.11, 0.13, 0.97). CONCLUSIONS: Split-bolus cone-beam CT showed excellent detectability of HCC. Sensitivity is comparable to HBP MR imaging and better than arterial phase MR imaging.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/diagnóstico por imagem
Carcinoma Hepatocelular/terapia
Quimioembolização Terapêutica/métodos
Tomografia Computadorizada de Feixe Cônico
Meios de Contraste/administração & dosagem
Gadolínio DTPA/administração & dosagem
Neoplasias Hepáticas/diagnóstico por imagem
Neoplasias Hepáticas/terapia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (gadolinium ethoxybenzyl DTPA); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


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[PMID]:28456697
[Au] Autor:Satogami K; Ino Y; Kubo T; Tanimoto T; Orii M; Matsuo Y; Ota S; Yamaguchi T; Shiono Y; Shimamura K; Katayama Y; Aoki H; Nishiguchi T; Ozaki Y; Yamano T; Kameyama T; Kuroi A; Kitabata H; Tanaka A; Hozumi T; Akasaka T
[Ad] Endereço:Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
[Ti] Título:Impact of Plaque Rupture Detected by Optical Coherence Tomography on Transmural Extent of Infarction After Successful Stenting in ST-Segment Elevation Acute Myocardial Infarction.
[So] Source:JACC Cardiovasc Interv;10(10):1025-1033, 2017 May 22.
[Is] ISSN:1876-7605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of the present study was to investigate the association between plaque rupture (PR) assessed by optical coherence tomography (OCT), and the transmural extent of infarction (TEI) assessed by contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). BACKGROUND: PR is associated with larger infarct size as assessed by cardiac enzymes in STEMI patients. CE-CMR is a favorable method to assess TEI, which can predict the prognosis of STEMI patients. METHODS: First, STEMI patients with primary PCI within 12 h after onset were enrolled and divided into 2 groups according to presence (n = 71) or absence (n = 32) of PR at the culprit lesion as assessed by pre-intervention OCT. CE-CMR was performed at 1 week after primary PCI. RESULTS: The frequency of no-reflow phenomenon (37% vs. 16%; p = 0.032) and distal embolization (24% vs. 6%; p = 0.032) was significantly higher in the rupture group compared with the non-rupture group. TEI grade was significantly greater in the rupture group (28% vs. 15% in grade 3 and 45% vs. 13% in grade 4; p < 0.001). Microvascular obstruction was more frequently seen in the rupture group (39% vs. 19%; p = 0.039). Multivariate analysis identified PR (odds ratio: 6.60, 95% confidence interval: 2.19 to 21.69; p < 0.001) and no statin use before admission (odds ratio: 3.37, 95% confidence interval: 1.06 to 11.19; p = 0.039) as independent predictors of TEI grade 3 or 4. CONCLUSIONS: PR as assessed by OCT is associated with greater TEI as assessed by CE-CMR in STEMI patients after primary PCI.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/terapia
Vasos Coronários/diagnóstico por imagem
Imagem por Ressonância Magnética
Miocárdio/patologia
Intervenção Coronária Percutânea/instrumentação
Placa Aterosclerótica
Infarto do Miocárdio com Supradesnível do Segmento ST/terapia
Stents
Tomografia de Coerência Óptica
[Mh] Termos MeSH secundário: Idoso
Distribuição de Qui-Quadrado
Meios de Contraste/administração & dosagem
Angiografia Coronária
Doença da Artéria Coronariana/diagnóstico por imagem
Eletrocardiografia
Embolia/diagnóstico por imagem
Embolia/etiologia
Feminino
Gadolínio DTPA/administração & dosagem
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Fenômeno de não Refluxo/diagnóstico por imagem
Fenômeno de não Refluxo/etiologia
Razão de Chances
Intervenção Coronária Percutânea/efeitos adversos
Valor Preditivo dos Testes
Estudos Retrospectivos
Fatores de Risco
Ruptura Espontânea
Infarto do Miocárdio com Supradesnível do Segmento ST/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29244853
[Au] Autor:Ko Y; Kim J; Park JK; Kim H; Cho JY; Kang SB; Ahn S; Lee KJ; Lee KH
[Ad] Endereço:Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.
[Ti] Título:Limited detection of small (≤ 10 mm) colorectal liver metastasis at preoperative CT in patients undergoing liver resection.
[So] Source:PLoS One;12(12):e0189797, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To retrospectively determine the sensitivity of preoperative CT in the detection of small (≤ 10 mm) colorectal liver metastasis (CRLM) nodules in patients undergoing liver resection. METHODS: The institutional review board approved the study and waived informed consent. We included 461 pathologically confirmed CRLM nodules in 211 patients (including 71 women; mean age, 66.4 years) who underwent 229 liver resections following abdominal CT. Prior to 163 resections, gadoxetic acid-enhanced liver MR imaging was also performed. Nodules were matched between pathology reports and prospective CT reports following a predefined algorithm. Per-nodule sensitivity of CT was calculated by nodule-size category. Generalized estimating equations were used to adjust for within-case correlation. RESULTS: Fourteen nodule sizes were missing in the pathology report. Nodules of 1-5 mm and 6-10 mm accounted for 8.1% (n = 36) and 23.5% (n = 105) of the remaining 447 nodules, and the number of nodules gradually decreased as nodule size increased beyond 10 mm. The overall sensitivity of CT was 81.2% (95% confidence interval, 77.1%, 85.2%; 365/461). The sensitivity was 8% (0%, 17%; 3/36), 55% (45%, 65%; 59/105), 91%, 95%, and 100% for nodules of 1-5 mm, 6-10 mm, 11-15 mm, 16-20 mm, and >20 mm, respectively. The nodule-size distribution was similar between resections undergoing gadoxetic acid-enhanced MR imaging and those not undergoing the MR imaging. CONCLUSION: CT has limited sensitivity for nodules of ≤ 10 mm and particularly of ≤ 5 mm.
[Mh] Termos MeSH primário: Neoplasias Colorretais/diagnóstico por imagem
Neoplasias Hepáticas/diagnóstico por imagem
Fígado/diagnóstico por imagem
Metástase Neoplásica/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Neoplasias Colorretais/patologia
Neoplasias Colorretais/cirurgia
Meios de Contraste/uso terapêutico
Feminino
Gadolínio DTPA
Hepatectomia
Seres Humanos
Fígado/patologia
Fígado/cirurgia
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/secundário
Neoplasias Hepáticas/cirurgia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Metástase Neoplásica/patologia
Período Pré-Operatório
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (gadolinium ethoxybenzyl DTPA); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189797


  5 / 11198 MEDLINE  
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[PMID]:28458595
[Au] Autor:Korean Society of Abdominal Radiology
[Ti] Título:Diagnosis of Hepatocellular Carcinoma with Gadoxetic Acid-Enhanced MRI: 2016 Consensus Recommendations of the Korean Society of Abdominal Radiology.
[So] Source:Korean J Radiol;18(3):427-443, 2017 May-Jun.
[Is] ISSN:2005-8330
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Diagnosis of hepatocellular carcinoma (HCC) with gadoxetic acid-enhanced liver magnetic resonance imaging (MRI) poses certain unique challenges beyond the scope of current guidelines. The regional heterogeneity of HCC in demographic characteristics, prevalence, surveillance, and socioeconomic status necessitates different treatment approaches, leading to variations in survival outcomes. Considering the medical practices in Korea, the Korean Society of Abdominal Radiology (KSAR) study group for liver diseases has developed expert consensus recommendations for diagnosis of HCC by gadoxetic acid-enhanced MRI with updated perspectives, using a modified Delphi method. During the 39th Scientific Assembly and Annual Meeting of KSAR (2016), consensus was reached on 12 of 16 statements. These recommendations might serve to ensure a more standardized diagnosis of HCC by gadoxetic acid-enhanced MRI.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/diagnóstico
Meios de Contraste/química
Gadolínio DTPA/química
Neoplasias Hepáticas/diagnóstico
[Mh] Termos MeSH secundário: Carcinoma Hepatocelular/diagnóstico por imagem
Carcinoma Hepatocelular/patologia
Seres Humanos
Neoplasias Hepáticas/diagnóstico por imagem
Neoplasias Hepáticas/patologia
Imagem por Ressonância Magnética
Radiografia Abdominal
República da Coreia
Sensibilidade e Especificidade
Sociedades Científicas
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); 0 (gadolinium ethoxybenzyl DTPA); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.3348/kjr.2017.18.3.427


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[PMID]:28458596
[Au] Autor:Lee GM; Kim YR; Ryu JH; Kim TH; Cho EY; Lee YH; Yoon KH
[Ad] Endereço:Department of Radiology, Wonkwang University School of Medicine, Iksan 54538, Korea.
[Ti] Título:Quantitative Measurement of Hepatic Fibrosis with Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Patients with Chronic Hepatitis B Infection: A Comparative Study on Aspartate Aminotransferase to Platelet Ratio Index and Fibrosis-4 Index.
[So] Source:Korean J Radiol;18(3):444-451, 2017 May-Jun.
[Is] ISSN:2005-8330
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To quantitatively measure hepatic fibrosis on gadoxetic acid-enhanced magnetic resonance (MR) in chronic hepatitis B (CHB) patients and identify the correlations with aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) values. MATERIALS AND METHODS: This study on gadoxetic acid-enhanced 3T MR imaging included 81 patients with CHB infection. To quantitatively measure hepatic fibrosis, MR images were analyzed with an aim to identify inhomogeneous signal intensities calculated from a coefficient of variation (CV) map in the liver parenchyma. We also carried out a comparative analysis between APRI and FIB-4 based on metaregression results. The diagnostic performance of the CV map was evaluated using a receiver-operating characteristic (ROC) curve. RESULTS: In the MR images, the mean CV values in control, groups I, II, and III based on APRI were 4.08 ± 0.92, 4.24 ± 0.80, 5.64 ± 1.11, and 5.73 ± 1.28, respectively ( < 0.001). In CHB patients grouped by FIB-4, the mean CV values of groups A, B, and C were 4.22 ± 0.95, 5.40 ± 1.19, and 5.71 ± 1.17, respectively ( < 0.001). The mean CV values correlated well with APRI ( = 0.392, < 0.001) and FIB-4 ( = 0.294, < 0.001). In significant fibrosis group, ROC curve analysis yielded an area under the curve of 0.875 using APRI and 0.831 using FIB-4 in HB, respectively. CONCLUSION: Gadoxetic acid-enhanced MR imaging for calculating a CV map showed moderate correlation with APRI and FIB-4 values and could be employed to quantitatively measure hepatic fibrosis in patients with CHB.
[Mh] Termos MeSH primário: Aspartato Aminotransferases/análise
Plaquetas/citologia
Gadolínio DTPA/química
Hepatite B Crônica/diagnóstico
Cirrose Hepática/diagnóstico por imagem
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Área Sob a Curva
Estudos de Casos e Controles
Feminino
Hepatite B Crônica/complicações
Seres Humanos
Cirrose Hepática/complicações
Cirrose Hepática/patologia
Masculino
Meia-Idade
Contagem de Plaquetas
Curva ROC
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (gadolinium ethoxybenzyl DTPA); EC 2.6.1.1 (Aspartate Aminotransferases); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.3348/kjr.2017.18.3.444


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[PMID]:27770230
[Au] Autor:An C; Rhee H; Han K; Choi JY; Park YN; Park MS; Kim MJ; Park S
[Ad] Endereço:Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
[Ti] Título:Added value of smooth hypointense rim in the hepatobiliary phase of gadoxetic acid-enhanced MRI in identifying tumour capsule and diagnosing hepatocellular carcinoma.
[So] Source:Eur Radiol;27(6):2610-2618, 2017 Jun.
[Is] ISSN:1432-1084
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To examine the added value of considering smooth hypointense rim in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI as capsule appearance for diagnosing tumour capsules and hepatocellular carcinoma (HCC). METHODS: A total of 377 hepatic lesions (330 HCCs, 35 non-HCC malignancies and 12 benign) were included from 345 patients who underwent resection after MRI between January 2008 and December 2011. Two radiologists assessed the presence or absence of conventional capsule appearance and smooth hypointense rim in the HBP, and categorized each hepatic lesion according to the Liver Imaging Reporting and Data System. Difference in diagnostic performance was evaluated using the generalized estimating equation method. RESULTS: For identifying capsule, the sensitivity and accuracy of HBP hypointense rim were significantly higher than those of conventional capsule appearance (81.5 % vs. 57.8 % and 76.1 % vs. 59.4 %, respectively; P < 0.001). For diagnosing HCC, the sensitivity and accuracy of LR-5 or LR-5 V were significantly higher when the HBP hypointense rim was also considered capsule appearance (83 % vs. 72.7 % and 84.1 % vs. 75.1 %, respectively; P < 0.001), with the same specificity (91.5 %). CONCLUSIONS: Regarding smooth hypointense rim in the HBP as capsule appearance could improve the detection of tumour capsule and the diagnosis of HCC. KEY POINTS: • Identifying tumour capsule is important for diagnosis of hepatocellular carcinoma (HCC). • Gadoxetic acid-enhanced MRI provides hepatobiliary phase (HBP) images. • Smooth hypointense rim seen in HBP may represent tumour capsule. • Regarding smooth hypointense rim as capsule appearance may improve HCC diagnosis.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/diagnóstico
Neoplasias Hepáticas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Meios de Contraste
Feminino
Gadolínio DTPA
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (gadolinium ethoxybenzyl DTPA); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1007/s00330-016-4634-6


  8 / 11198 MEDLINE  
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[PMID]:29049250
[Au] Autor:Wu WP; Hoi CI; Chen RC; Lin CP; Chou CT
[Ad] Endereço:aDepartment of Radiology, Chang-Hua Christian Hospital, Changhua bDepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei cDepartment of Radiology, Centro Medico Pedder, Macau dBrain Connectivity Laboratory, National Yang-Ming University, Taipei, Taiwan.
[Ti] Título:Comparison of the efficacy of Gd-EOB-DTPA-enhanced magnetic resonance imaging and magnetic resonance elastography in the detection and staging of hepatic fibrosis.
[So] Source:Medicine (Baltimore);96(42):e8339, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study compared the efficacy of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and magnetic resonance elastography (MRE) in the estimation of hepatic fibrosis stages with histopathologic correlation.This retrospective study included 104 patients (87 men and 17 women; mean age, 60.6 ± 10.6 years) with chronic liver disease who underwent both Gd-EOB-DTPA-enhanced MRI and MRE. The relative enhancement (RE) ratio of the liver parenchyma and the contrast enhancement index (CEI) were calculated as (SIpostliver - SIpreliver)/SIpreliver and SIpost/SIpre, respectively, where SIpost and SIpre were the liver-to-muscle signal intensity ratios on the hepatobiliary phase images and noncontrast-enhanced images, respectively. The liver stiffness values were measured using MRE stiffness maps. The diagnostic performance of MRE, RE ratios, and CEI values for hepatic fibrosis staging were compared.The distribution of fibrosis stages was as follows: F0, n = 3 (2.9%); F1, n = 12 (11.5%); F2, n = 17 (16.3%); F3, n = 26 (25.0%); and F4, n = 46 (44.2%). MRE, RE ratios, and CEI values correlated significantly with hepatic fibrosis (rs = .79, -.35, -.25, respectively, P < .05). MRE showed a significantly higher diagnostic performance than did RE ratios and CEI values for each fibrosis stage, except while distinguishing the F1 fibrosis stage (CEI, P = .15). A cutoff value of RE ratio = 0.89 can be used to identify patients with significant hepatic fibrosis, with positive predictive value, sensitivity, specificity, and negative predictive value of 93.2%, 61.8%, 73.3%, and 24.4%, respectively.Gd-EOB-DTPA-enhanced MRI can potentially predict significant hepatic fibrosis. However, the diagnostic performance of MRE for hepatic fibrosis staging was superior to that of Gd-EOB-DTPA-enhanced MRI.
[Mh] Termos MeSH primário: Técnicas de Imagem por Elasticidade/métodos
Cirrose Hepática/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Idoso
Meios de Contraste
Feminino
Gadolínio DTPA
Seres Humanos
Fígado/patologia
Cirrose Hepática/diagnóstico
Masculino
Meia-Idade
Estudos Retrospectivos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (gadolinium ethoxybenzyl DTPA); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008339


  9 / 11198 MEDLINE  
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[PMID]:28982888
[Au] Autor:Morine Y; Enkhbold C; Imura S; Ikemoto T; Iwahashi S; Saito YU; Yamada S; Utsunomiya T; Shimada M
[Ad] Endereço:Department of Surgery, Institute of Biochemical Sciences, Tokushima University Graduate School, Tokushima, Japan ymorine@tokushima-u.ac.jp.
[Ti] Título:Accurate Estimation of Functional Liver Volume Using Gd-EOB-DTPA MRI Compared to MDCT/ Tc-SPECT Fusion Imaging.
[So] Source:Anticancer Res;37(10):5693-5700, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: We assessed the utility of dynamic magnetic resonance imaging (MRI) with gadoxetate-ethoxybenzyl-diethylenetriamine penta-aceticpenta-acetic acid (Gd-EOB-DTPA) (EOB-MRI) for estimating functional liver volume compared to Tc-galactosyl albumin single-photon-emission computed tomography ( Tc-GSA SPECT). PATIENTS AND METHODS: Regional functional liver volume (left lateral, medial, right anterior, right posterior) of 58 hepatectomized patients was assessed using EOB-MRI and Tc-GSA SPECT, and compared to the actual liver volume with MDCT-3D volumetry. RESULTS: Tc-GSA SPECT found a significantly lower functional volume of the left lateral section than the actual volume found by MDCT-3D volumetry (p=0.003) and EOB-MRI (p<0.001). Functional liver volume of right anterior section found with Tc-GSA SPECT was significantly higher than that found by MDCT-3D volumetry (p=0.04), despite no differences in asialoglycoprotein receptor 1 (ASGR1) or ATP-dependent organic anion transporting polypeptide 1 (OATP) expression between the left lateral and right anterior sections. CONCLUSION: Tc-GSA SPECT might underestimate the function of the left lobe and overestimate that of the right lobe. Therefore, EOB-MRI could be better for estimating the true regional functional liver reserve.
[Mh] Termos MeSH primário: Meios de Contraste/administração & dosagem
Gadolínio DTPA/administração & dosagem
Fígado/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Tomografia Computadorizada Multidetectores
Compostos Radiofarmacêuticos/administração & dosagem
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único/métodos
Agregado de Albumina Marcado com Tecnécio Tc 99m/administração & dosagem
Pentetato de Tecnécio Tc 99m/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Receptor de Asialoglicoproteína/análise
Biomarcadores/análise
Biópsia
Feminino
Hepatectomia
Seres Humanos
Imuno-Histoquímica
Fígado/química
Fígado/cirurgia
Masculino
Meia-Idade
Tamanho do Órgão
Transportadores de Ânions Orgânicos/análise
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ASGR1 protein, human); 0 (Asialoglycoprotein Receptor); 0 (Biomarkers); 0 (Contrast Media); 0 (Organic Anion Transporters); 0 (Radiopharmaceuticals); 0 (SLCO1A2 protein, human); 0 (Technetium Tc 99m Aggregated Albumin); 0 (gadolinium ethoxybenzyl DTPA); 0 (technetium Tc 99m DTPA-galactosyl-human serum albumin); K2I13DR72L (Gadolinium DTPA); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  10 / 11198 MEDLINE  
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Texto completo
[PMID]:28838961
[Au] Autor:Jablonowski R; Chaudhry U; van der Pals J; Engblom H; Arheden H; Heiberg E; Wu KC; Borgquist R; Carlsson M
[Ad] Endereço:From the Clinical Physiology (R.J., H.E., H.A., E.H., M.C.) and Cardiology (U.C., J.v.d.P., R.B.), Department of Clinical Sciences, Lund University, Lund University Hospital, Sweden; Department of Biomedical Engineering and Centre for Mathematical Sciences, Faculty of Engineering, Lund University, S
[Ti] Título:Cardiovascular Magnetic Resonance to Predict Appropriate Implantable Cardioverter Defibrillator Therapy in Ischemic and Nonischemic Cardiomyopathy Patients Using Late Gadolinium Enhancement Border Zone: Comparison of Four Analysis Methods.
[So] Source:Circ Cardiovasc Imaging;10(9), 2017 Sep.
[Is] ISSN:1942-0080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Late gadolinium enhancement (LGE) border zone on cardiac magnetic resonance imaging has been proposed as an independent predictor of ventricular arrhythmias. The purpose was to determine whether size and heterogeneity of LGE predict appropriate implantable cardioverter defibrillator (ICD) therapy in ischemic cardiomyopathy (ICM) and nonischemic cardiomyopathy (NICM) patients and to evaluate 4 LGE border-zone algorithms. METHODS AND RESULTS: ICM and NICM patients who underwent LGE cardiac magnetic resonance imaging prior to ICD implantation were retrospectively included. Two semiautomatic algorithms, expectation maximization, weighted intensity, a priori information and a weighted border zone algorithm, were compared with a modified full-width half-maximum and a 2-3SD threshold-based algorithm (2-3SD). Hazard ratios were calculated per 1% increase in LGE. A total of 74 ICM and 34 NICM were followed for 63 months (1-140) and 52 months (0-133), respectively. ICM patients had 27 appropriate ICD events, and NICM patients had 7 ICD events. In ICM patients with primary prophylactic ICD, LGE border zone predicted ICD therapy in univariable and multivariable analysis measured by the expectation maximization, weighted intensity, a priori information, weighted border zone, and modified full-width half-maximum algorithms (hazard ratios 1.23, 1.22, and 1.05, respectively; <0.05; negative predictive value 92%). For NICM, total LGE by all 4 methods was the strongest predictor (hazard ratios, 1.03-1.04; <0.05), though the number of events was small. CONCLUSIONS: Appropriate ICD therapy can be predicted in ICM patients with primary prevention ICD by quantifying the LGE border zone. In NICM patients, total LGE but not LGE border zone had predictive value for ICD therapy. However, the algorithms used affects the predictive value of these measures.
[Mh] Termos MeSH primário: Arritmias Cardíacas/prevenção & controle
Cardiomiopatias/diagnóstico por imagem
Cardiomiopatias/terapia
Meios de Contraste/administração & dosagem
Técnicas de Apoio para a Decisão
Desfibriladores Implantáveis
Cardioversão Elétrica/instrumentação
Imagem Cinética por Ressonância Magnética
Infarto do Miocárdio/diagnóstico por imagem
Seleção de Pacientes
Prevenção Primária/instrumentação
[Mh] Termos MeSH secundário: Idoso
Algoritmos
Arritmias Cardíacas/etiologia
Arritmias Cardíacas/fisiopatologia
Cardiomiopatias/etiologia
Cardiomiopatias/fisiopatologia
Intervalo Livre de Doença
Feminino
Gadolínio DTPA/administração & dosagem
Compostos Heterocíclicos/administração & dosagem
Seres Humanos
Processamento de Imagem Assistida por Computador
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Análise Multivariada
Infarto do Miocárdio/complicações
Miocárdio/patologia
Compostos Organometálicos/administração & dosagem
Valor Preditivo dos Testes
Modelos de Riscos Proporcionais
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Procedimentos Desnecessários
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Heterocyclic Compounds); 0 (Organometallic Compounds); 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE



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